CELL GENESYS INC
DEF 14A, 2000-04-28
PHARMACEUTICAL PREPARATIONS
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                                  SCHEDULE 14A
                                 (Rule 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION

           PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES
                     EXCHANGE ACT OF 1934 (AMENDMENT NO. __)

Filed by the Registrant                       [X]
Filed by a party other than the Registrant    [ ]

Check the appropriate box:
[ ]  Preliminary Proxy Statement           [ ]  Confidential, for Use of the
[X]  Definitive Proxy Statement                 Commission Only (as permitted by
[ ]  Definitive Additional Materials            Rule 14a-6(e)(2))
[ ]  Soliciting Material Pursuant to
     Rule 14a-11(c) or Rule 14a-12


                               Cell Genesys, Inc.
           ----------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)


           ----------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of filing fee (Check the appropriate box):

[X]     No fee required.
[ ]     Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

(1)     Title of each class of securities to which transactions applies:

(2)     Aggregate number of securities to which transactions applies:

(3)     Per unit  price  or  other  underlying  value  of  transaction  computed
        pursuant  to  Exchange  Act Rule 0-11 (set forth the amount on which the
        filing fee is calculated and state how it was determined):

(4)     Proposed maximum aggregate value of transaction:

(5)     Total fee paid:

        [ ]      Fee paid previously with preliminary materials.

        [ ]      Check  box if any  part of the fee is  offset  as  provided  by
                 Exchange Act Rule  0-11(a)(2) and identify the filing for which
                 the offsetting fee was paid  previously.  Identify the previous
                 filing  by  registration  statement  number,  or  the  Form  or
                 Schedule and the date of its filing.

(1)     Amount previously paid:

(2)     Form, Schedule or Registration Statement No.:

(3)     Filing party:

(4)     Date filed:


<PAGE>


                            [Cell Genesys, Inc. Logo]

                                  CELL GENESYS

                                ----------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                                ----------------

                                  TO BE HELD ON
                                  June 8, 2000

TO THE STOCKHOLDERS:

         Notice is hereby given that the Annual Meeting of  Stockholders of Cell
Genesys, Inc., a Delaware corporation (the "Company"), will be held on Thursday,
June 8, 2000 at 10:00 a.m., local time, at the Company's offices at 342 Lakeside
Drive, Foster City, California, for the following purposes:

         1.       To elect  directors to serve until the next annual  meeting of
                  stockholders or until their successors are elected.

         2.       To approve an amendment to the Company's 1998 Incentive  Stock
                  Plan to increase the number of shares of common stock reserved
                  for future issuance by 1,500,000 shares.

         3.       To  approve  an  amendment  to the  Company's  Employee  Stock
                  Purchase Plan to increase the number of shares of common stock
                  reserved for future issuance by 150,000 shares.

         4.       To ratify the  appointment of Ernst & Young LLP as independent
                  auditors of the  Company  for the fiscal year ending  December
                  31, 2000.

         5.       To transact  such other  business as may properly  come before
                  the meeting or any adjournment thereof.

         These items of business are more fully described in the Proxy Statement
accompanying this notice.

         Only  stockholders of record at the close of business on April 12, 2000
are  entitled  to  notice  of and to vote  at the  meeting  and any  adjournment
thereof.

         All stockholders are cordially invited to attend the meeting in person.
However, to assure your  representation at the meeting,  please mark, sign, date
and return the  enclosed  proxy card as soon as possible in the  postage-prepaid
envelope  enclosed for that purpose.  Any stockholder  attending the meeting may
vote in person even if the stockholder has returned a proxy.


                                        Sincerely,


                                        Matthew J. Pfeffer
                                        Assistant Secretary


Foster City, California
April 28, 2000


- --------------------------------------------------------------------------------
IMPORTANT:  WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING,  PLEASE  COMPLETE AND
PROMPTLY RETURN THE ENCLOSED PROXY IN THE ENVELOPE PROVIDED.
- --------------------------------------------------------------------------------


<PAGE>


                               CELL GENESYS, INC.
                               342 Lakeside Drive
                              Foster City, CA 94404

                                ----------------

               PROXY STATEMENT FOR ANNUAL MEETING OF STOCKHOLDERS

                                ----------------

                 INFORMATION CONCERNING SOLICITATION AND VOTING


General

         The enclosed  proxy is solicited on behalf of the board of directors of
Cell Genesys,  Inc., a Delaware  Corporation,  ("Cell Genesys" or the "Company")
for use at the Annual Meeting of  Stockholders  to be held on Thursday,  June 8,
2000 at 10:00 a.m.,  local time, or at any  adjournment of the meeting,  for the
purposes set forth in this Proxy  Statement  and in the  accompanying  Notice of
Annual Meeting of Stockholders. The annual meeting will be held at the Company's
offices at 342 Lakeside  Drive,  Foster City,  California  94404.  The Company's
telephone number is (650) 425-4400.

         These proxy  solicitation  materials  were mailed on or about April 28,
2000,  together with the Company's  1999 Annual Report to  Stockholders,  to all
stockholders entitled to vote at the meeting.

Record Date

         Stockholders  of record at the close of business on April 12, 2000 (the
"Record  Date") are  entitled  to notice of and to vote at the  meeting.  At the
Record Date,  33,668,366  shares of the  Company's  common stock were issued and
outstanding.

Revocability of Proxies

         Any proxy  given  pursuant to this  solicitation  may be revoked by the
person  giving it at any time  before  its use by  delivering  to the  Company a
written  notice of revocation  or a duly executed  proxy bearing a later date or
time or by attending the meeting and voting in person.

Voting and Solicitation

         Every stockholder voting in the election of directors may cumulate such
stockholder's votes and give one candidate a number of votes equal to the number
of  directors  to be elected  multiplied  by the  number of shares  held by such
stockholder,  or distribute the stockholder's  votes on the same principle among
as many candidates as the stockholder may select,  provided that votes cannot be
cast for more candidates than the number of directors to be elected. However, no
stockholder  shall be entitled to cumulate votes unless the candidate's name has
been placed in nomination prior to the voting and the stockholder,  or any other
stockholder,  has  given  notice  at the  meeting  prior  to the  voting  of the
intention to cumulate the stockholder's votes. On all other matters,  each share
has one vote.

         The cost of  soliciting  proxies will be borne by the Company.  Proxies
may also be  solicited  by  certain of the  Company's  directors,  officers  and
employees,   without  additional  compensation,   personally  or  by  telephone,
facsimile or letter.

Quorum; Abstentions; Broker Non-Votes

         A quorum is required for the  transaction of business during the annual
meeting. A quorum is present when a majority of shareholder votes are present in
person or by proxy.  Shares that are voted "FOR",  "AGAINST" or  "WITHHELD" on a
matter are treated as being present at the meeting for purposes of  establishing
a quorum and are also  treated as shares  cast by the  common  stock  present in
person or represented by proxy at the annual meeting and entitled to vote on the
subject matter (the "Votes Cast").

         The Company will count abstentions for purposes of determining both (i)
the presence or absence of a quorum for the transaction of business and (ii) the
total number of Votes Cast with  respect to a proposal  (other than the election
of  directors).  Abstentions  will have the same  effect as a vote  against  the
proposal.

                                        1

<PAGE>


         Broker  non-votes  will be counted  for  purposes  of  determining  the
presence  or  absence  of a  quorum  for the  transaction  of  business.  Broker
non-votes  will not be counted for purposes of  determining  the number of Votes
Cast with respect to the particular  proposal.  Thus, a broker non-vote will not
have any effect on the outcome of the voting on a proposal.

Deadline for Receipt of Stockholder Proposals

         The  attached  proxy  card  grants  the  proxy  holders   discretionary
authority to vote on any matter raised at the 2000 annual meeting. Proposals for
the  Company's  2001  Annual  Meeting of  Stockholders  must be  received by the
Company no later than December 30, 2000 in order to be considered  for inclusion
in the proxy statement and form of proxy relating to the Company's 2001 meeting.

         If a  shareholder  intends  to  submit a  proposal  at the 2001  annual
meeting that is not eligible for inclusion in the proxy statement and proxy, the
stockholder must do so no later than March 14, 2001. If such a shareholder fails
to comply with the foregoing notice provision, the proxy holders will be allowed
to use their  discretionary  authority  when the  proposal is raised at the 2001
annual meeting.


                                  PROPOSAL ONE

                              ELECTION OF DIRECTORS

Nominees

         Six directors are to be elected at the annual meeting. Unless otherwise
instructed,  the proxy  holders  will vote the proxies  received by them for the
Company's six nominees named below,  all of whom are presently  directors of the
Company.  If any  nominee  of the  Company is unable or  declines  to serve as a
director at the time of the annual  meeting,  the proxies  will be voted for any
nominee  designated  by the present  board of directors to fill the vacancy.  If
additional  persons are nominated  for election as directors,  the proxy holders
intend to vote all proxies  received by them in such a manner in accordance with
cumulative  voting (if applicable) as will assure the election of as many of the
nominees listed below as possible,  and, in such event, the specific nominees to
be voted for will be determined by the proxy holders.  Joseph E. Maroun will not
seek election for the upcoming term of office. Mr. Maroun has been a director of
Cell  Genesys  since 1995 and we thank him for his service  during the past five
years.

         The Company is not presently aware of any nominee who will be unable or
will decline to serve as a director.  The term of office of each person  elected
as a director will continue  until the next annual  meeting of  stockholders  or
until a successor has been elected and qualified.

         The names of the nominees and certain  information about them as of the
Record Date are listed below.



                                                                       Director
Names of Nominees          Age         Principal Occupation             Since
- -----------------          ---         --------------------             -----
Stephen A. Sherwin, M.D. . 51   Chairman of the Board, President         1990
                                and Chief Executive Officer of
                                the Company

David W. Carter .......... 61   Chairman of the Board of Xenogen         1997
                                Corporation

James M. Gower ........... 52   Chairman of the Board and Chief          1996
                                Executive Officer of Rigel, Inc.

John T. Potts, Jr., M.D. . 68   Director of Research,                    1997
                                Massachusetts General Hospital

Eugene L. Step ........... 71   Retired Executive Vice President,        1993
                                President -- Pharmaceutical
                                Division, Eli Lilly & Co.

Inder M. Verma, Ph.D. .... 52   Professor of Molecular Biology           1997
                                and Virology, The Salk Institute

                                2

<PAGE>


         Dr.  Sherwin has served as  president,  chief  executive  officer and a
director of the Company since March 1990. In March 1994, Dr. Sherwin was elected
to the additional position of chairman of the Company's board of directors. From
1983 to  1990,  Dr.  Sherwin  held  various  positions  at  Genentech,  Inc.,  a
biotechnology  company,  most recently as vice  president of clinical  research.
Prior to 1983, Dr.  Sherwin held various  positions on the staff of the National
Cancer  Institute.  Dr.  Sherwin  is a director  of  Abgenix,  Inc.,  Neurocrine
Biosciences, Inc., Rigel, Inc. and Calyx Therapeutics,  Inc. Dr. Sherwin holds a
B.A. from Yale University in biology and an M.D. from Harvard Medical School.

         Mr. Carter has served as a director of Cell Genesys since May 1997. Mr.
Carter has served as chairman of the board of directors  of Xenogen  Corporation
since November 1997. Previously, Mr. Carter served as president, chief executive
officer and chairman of the board of directors of Somatix  Therapy  Corporation.
Prior to 1991,  he was  president  and chief  operating  officer  of  Northfield
Laboratories. Mr. Carter also serves as a director of Immunogen, Inc. Mr. Carter
received a B.A. and an M.B.A. from Indiana University.

         Mr. Gower has served as a director of Cell Genesys  since July 1996. In
1996, Mr. Gower became chairman and chief executive  officer of Rigel, Inc. From
1992 to 1996,  Mr.  Gower  served as president  and chief  executive  officer of
Tularik,  Inc. From 1981 to 1990, he was with Genentech,  Inc., most recently as
senior vice president responsible for sales, marketing, business development and
product planning.  From 1972 to 1981, Mr. Gower served in a variety of positions
in sales and marketing at American Hospital Supply Corporation, most recently as
vice  president of  marketing.  Mr. Gower  received a B.S.  degree in operations
research and an M.B.A. from the University of Tennessee.

         Dr.  Potts has served as a  director  of Cell  Genesys  since May 1997.
Previously,  Dr. Potts had served as a director of Somatix  Therapy  Corporation
since March 1995. His career spans 40 years of distinguished  service in science
and medicine.  He earned his M.D. in 1957 from the  University of  Pennsylvania,
then trained at Massachusetts General Hospital and National Heart Institute.  At
the National  Institutes of Health, he became head of the section on polypeptide
hormones  prior to becoming  chief of  endocrinology  at  Massachusetts  General
Hospital  in 1968.  Dr.  Potts  served as  physician-in-chief  at  Massachusetts
General Hospital and Jackson  Professor of Clinical  Medicine at Harvard Medical
School from 1981 to 1996.  In September  1996,  Dr. Potts moved from the post of
physician-in-chief to director of research at Massachusetts General Hospital and
Jackson Distinguished Professor of Clinical Medicine at Harvard Medical School.

         Mr. Step was  appointed a director of Cell Genesys in March 1993.  From
1973 to 1992, Mr. Step served in various  positions in senior  management of Eli
Lilly and Company,  most recently as executive vice president,  president of the
pharmaceutical division and a member of the board of directors and its executive
committee.  Mr.  Step is a past  chairman  of the  board  of the  Pharmaceutical
Manufacturers  Association and a past president of the International  Federation
of  Pharmaceutical  Manufacturers  Association.  Mr.  Step is also a director of
Scios, Inc., Medco, Inc., Guidant Corporation,  Pathogenesis Corporation and DBT
Online Inc. Mr. Step holds a B.A.  degree in economics  from the  University  of
Nebraska and an M.S. in finance and accounting from the University of Illinois.

         Dr.  Verma has served as a  director  of Cell  Genesys  since May 1997.
Previously,  Dr. Verma had served as a director of Somatix  Therapy  Corporation
since June 1996. Dr. Verma is  co-director  of the  laboratory of genetics,  The
Salk  Institute.  He joined The Salk  Institute in 1974.  In 1995,  the National
Institutes of Health selected Dr. Verma to chair a committee reviewing the scope
and  advancement  of gene  therapy.  Currently,  Dr.  Verma  is also an  adjunct
professor, department of biology, at the University of California, San Diego and
has been a member of the faculty  since 1979.  Dr. Verma is also a member of the
National Academy of Sciences and the Institute of Medicine.

         There  are no  family  relationships  between  directors  or  executive
officers of the Company.

Required Vote

         The six nominees  receiving the highest number of affirmative  votes of
the shares  present or  represented  and  entitled  to be voted for them will be
elected as directors.

                                        3

<PAGE>


Board Meetings and Committees

         The board of directors of the Company held a total of fifteen  meetings
during the fiscal year ended December 31, 1999. Each director  attended at least
seventy-five  percent  of the  meetings  of the  board  of  directors  and  each
committee on which he served during 1999.

         The  board of  directors  has an  audit  committee  and a  compensation
committee. It does not have a nominating committee or a committee performing the
functions of a nominating committee.

         The audit  committee of the board of  directors  met three times during
fiscal year 1999 and consisted of Dr. Potts and Mr. Step.  During 2000,  Messrs.
Carter  and Gower  joined  the audit  committee  while Dr.  Potts left the audit
committee to join the  compensation  committee.  The audit committee  recommends
engagement of the Company's  independent  auditors and is primarily  responsible
for reviewing and approving the scope of the audit and other services  performed
by the Company's independent  auditors.  The audit committee is also responsible
for the Company's financial reporting,  accounting principles and its systems of
internal accounting controls.

         The compensation  committee of the board of directors,  which consisted
of  directors  Gower and Step,  met five times during  fiscal year 1999.  During
2000,  Dr. Potts  joined the  compensation  committee,  while Mr. Gower left the
compensation  committee to join the audit committee.  The compensation committee
reviews  and  approves  the  Company's  compensation  policies  as  well  as the
compensation of, and grant of stock options to, the executive officers.

Compensation Committee Interlocks and Insider Participation

         The Company's  compensation  committee was composed of directors  Gower
and Step during 1999 and will be  composed  of  directors  Potts and Step during
2000,  none of whom is or has been an officer or  employee of the  Company.  The
compensation   committee  makes   recommendations  to  the  board  of  directors
concerning salaries and incentive  compensation for officers of the Company. Dr.
Sherwin,  chairman of the board and chief executive  officer of the Company,  is
not a member of the compensation committee and cannot vote on matters decided by
the Committee.  He participates in compensation  committee discussions regarding
salaries and incentive  compensation for all employees of and consultants to the
Company,  except that Dr. Sherwin is excluded from discussions regarding his own
salary and incentive compensation.  No interlocking  relationship exists between
the  Company's  board of directors or  compensation  committee  and the board of
directors  or  compensation   committee  of  any  other  party,   nor  has  such
relationship existed in the past.


                                  PROPOSAL TWO

              APPROVAL OF AN AMENDMENT TO 1998 INCENTIVE STOCK PLAN

General

         The 1998 Incentive Stock Plan (the "Incentive Plan") was adopted by the
board of directors and initially approved by the stockholders in June, 1998. The
Incentive Plan will terminate by its own terms in 2008.

         Options granted under the Incentive Plan may be either  incentive stock
options, within the meaning of Section 422 of the Internal Revenue Code of 1986,
as amended (the "Code"),  or nonstatutory  options.  In addition,  the Incentive
Plan  provides  for the grant of stock  purchase  rights.  All such  options and
purchase rights are  collectively  referred to below as "Rights".  The Incentive
Plan is not a qualified deferred compensation plan under Code Section 401(a) and
is not subject to the provisions of the Employee  Retirement Income Security Act
of 1974 ("ERISA").

Proposal

         In April,  2000,  the board of  directors  approved an amendment to the
Incentive Plan to increase the number of shares  reserved for future issuance by
1,500,000 shares. The stockholders are being requested to approve this amendment
to the Incentive Plan.

                                        4

<PAGE>


         As of March 31,  2000,  options  to  purchase  71,188  shares  had been
exercised, options to purchase 1,443,107 shares were outstanding with a weighted
average  exercise  price of $7.085,  and  options  to  purchase  245,705  shares
remained available for future grant under the Incentive Plan. The closing market
price of the Company's common stock on March 31, 2000 was $21.313.


                          SUMMARY OF THE INCENTIVE PLAN

     Purposes of the Plan

         The purposes of the  Incentive  Plan are to attract and retain the best
available personnel, to provide additional long-term incentives to employees and
directors of the Company and to promote the success of the Company's business.

     Administration; Limits on Grants

         The Incentive  Plan is  administered  by the board of directors or by a
compensation  committee appointed by the board of directors and consisting of at
least two  members  of the board (in  either  case,  the  "Administrator").  The
compensation  committee  approves  the grant of stock  options to the  Company's
executive officers.  The board has sole discretion to interpret any provision of
the Incentive Plan.

         The federal tax code places  limits on the  deductibility,  for federal
income tax purposes,  of compensation paid to certain executive  officers of the
Company.  In order to preserve the Company's  ability to deduct the compensation
income  associated  with  options  and stock  purchase  rights  granted  to such
persons,  the Plan  provides  that no employee,  director or  consultant  may be
granted, in any fiscal year of the Company, options and stock purchase rights to
purchase more than 250,000 shares of common stock.  Notwithstanding  this limit,
however,  in  connection  with such  individual's  initial  employment  with the
Company,  he or she may be granted  options or stock purchase rights to purchase
up to an additional 250,000 shares of common stock.

         In addition  to the  foregoing  limitation  on  discretion  for certain
Rights,  there is a limit on the aggregate market value of shares subject to all
incentive  stock options held by an optionee  which may vest during any calendar
year. See "Tax Information -- Incentive Stock Options" below.

     Eligibility

         The Incentive Plan provides that Rights may be granted to the Company's
employees,  directors,  and consultants,  and to employees of and consultants to
the  Company's  majority-owned  subsidiaries.  Only  employees  may  be  granted
"incentive   stock  options"  as  defined  in  Section  422  of  the  Code.  The
Administrator  selects the optionees and  determines  the number of shares to be
subject to each option.

     Terms of Options

         Each option  granted under the Incentive Plan is evidenced by a written
stock  option  agreement  between the Company and the optionee and is subject to
the following additional terms and conditions:

                  (a) Duration and Termination of Options. Options granted under
         the  Incentive  Plan have a maximum  term of ten years from the date of
         grant. An option granted to a person who,  immediately before the grant
         of such option, owns more than ten percent of the voting power or value
         of all classes of stock of the Company may not have a term of more than
         five years.  No option may be  exercised  after the  expiration  of its
         term.

                  (b) Exercise of the Option.  The  Administrator  determines on
         the date of grant of each option  when the option will be  exercisable.
         Options granted to employees and directors generally become exercisable
         ("vest") over four years.

                           An  option   granted  under  the  Incentive  Plan  is
                  exercised by giving written notice of exercise to the Company,
                  specifying  the  number  of  shares  of  common  stock  to  be
                  purchased and tendering  payment of the purchase  price to the
                  Company.  Payment for shares issued upon exercise of an option
                  may,  depending on the terms of the option agreement,  consist
                  of cash,  check,  promissory  notes,  surrender  of  shares of
                  common stock owned by the optionee or such other consideration
                  as determined by the Administrator.

                                        5

<PAGE>


                  (c)  Exercise  Price.  The exercise  price of options  granted
         under the Incentive  Plan is determined by the board of directors.  The
         exercise  price of  incentive  stock  options  may not be less than 100
         percent of the fair  market  value of the  common  stock on the date of
         grant.  However,  the exercise price of incentive stock options granted
         to a person who owns more then ten percent of the voting power or value
         of all  classes  of stock  of the  Company  must  not be less  than 110
         percent of the fair market value on the date of grant. The common stock
         is currently traded on the Nasdaq National Market.  While the Company's
         stock is traded on the Nasdaq National Market, the fair market value is
         the reported closing price.

                  (d) Termination of Service.  Except as described  below, if an
         optionee's  employment by or services to the Company  terminate for any
         reason, the option is exercisable within a period of time determined by
         the board of  directors  or its  compensation  committee  to the extent
         vested on the date of  termination.  For  terminations  other than as a
         result of disability,  the time period is generally 3 months.  However,
         the time period cannot extend beyond the expiration date of the option.

                  (e)  Nontransferability of Options. An option is generally not
         transferable by the optionee, other than by will or the laws of descent
         and distribution. During the optionee's lifetime, only the optionee may
         exercise the option.

     Stock Purchase Rights

         In  the  case  of  stock  purchase  rights,  unless  the  Administrator
determines  otherwise,  the restricted stock purchase  agreement shall grant the
Company a  repurchase  option  exercisable  upon the  voluntary  or  involuntary
termination  of the  purchaser's  employment  with the  Company  for any  reason
(including  death or  disability).  The  purchase  price for shares  repurchased
pursuant to the restricted stock purchase  agreement shall be the original price
paid by the purchaser and may be paid by cancellation of any indebtedness of the
purchaser to the Company. The repurchase option shall lapse at a rate determined
by the Administrator.

     Changes in Capitalization

         In the  event  of  changes  in the  common  stock  by  reason  of stock
dividends,    split-ups   or   combinations   of   shares,    reclassifications,
recapitalizations,  mergers, consolidations,  reorganizations,  or liquidations,
the board or its  compensation  committee will adjust the exercise price and the
number and class of shares subject to each option or stock purchase right as the
board or its compensation committee deems appropriate.  Such adjustment is final
and conclusive.

         In the event of a liquidation or dissolution,  any unexercised  options
or  stock  purchase  rights  will  terminate.  The  Administrator  may,  in  its
discretion,  provide that each optionee  shall have the right to exercise all of
the optionee's options and stock purchase rights,  including those not otherwise
exercisable,  until  the date ten (10)  days  prior to the  consummation  of the
liquidation or dissolution.

         In  connection  with any merger or sale of assets of the Company,  each
outstanding  option or stock  purchase  right shall be assumed or an  equivalent
option or right  substituted  by the  successor  corporation.  If the  successor
corporation  refuses  to assume  the  options  and stock  purchase  rights or to
substitute  substantially  equivalent  options and stock  purchase  rights,  the
optionee  shall have the right to exercise the option or stock purchase right to
all the optioned  stock,  including  shares not otherwise  exercisable.  In such
event,  the  Administrator  shall notify the  optionee  that the option or stock
purchase right is fully  exercisable for fifteen (15) days from the date of such
notice and that the option or stock purchase right terminates upon expiration of
such period.

     Amendment and Termination

         The board may at any time amend or terminate the Incentive Plan without
approval  of  the   stockholders.   The  Company  currently  intends  to  obtain
stockholder  approval  of any  amendment  to the  Incentive  Plan to the  extent
necessary  to comply with Rule 16b-3 under the  Securities  Exchange Act of 1934
(the "Exchange Act"), with Section 422 of the Code, or with any other applicable
law or  regulation,  including  requirements  of the Nasdaq  Stock  Market.  Any
amendment  or  termination  of the  Incentive  Plan is  subject to the rights of
optionees under agreements entered into prior to such amendment or termination.

                                        6

<PAGE>


     Tax Information

         The following is a brief summary of the federal income tax consequences
of transactions  under the Incentive Plan based on federal securities and income
tax laws in effect March 1, 2000.  This summary is not intended to be exhaustive
and does not discuss the tax consequences of a participant's death or provisions
of the income tax laws of any municipality, state or foreign country in which an
optionee may reside.

         Options granted under the Incentive Plan may be either  incentive stock
options, as defined in Section 422 of the Code, or nonstatutory options.

         Incentive  Stock  Options.  No  taxable  income  is  recognized  by the
optionee  upon grant or  exercise  of an  incentive  stock  option  (unless  the
alternative  minimum tax rules apply).  If common stock is issued to an optionee
pursuant to the exercise of an incentive stock option,  and if no  disqualifying
disposition  of such shares is made by such optionee  within two years after the
date of grant and within one year after the date of  exercise  by the  optionee,
then (i) upon the resale of such  shares,  any amount  realized in excess of the
option  exercise  price will be treated as  long-term  capital gain and any loss
sustained will be long-term  capital loss, and (ii) no deduction will be allowed
to the Company for federal  income tax  purposes.  The  exercise of an incentive
stock option may result in alternative minimum tax liability to the optionee.

         If common stock acquired upon the exercise of an incentive stock option
is disposed of before the expiration of either holding period  described  above,
generally (i) the optionee will  recognize  income in the year of disposition in
an amount equal to the excess (if any) of the fair market value of the shares at
exercise (or, if less,  the amount  realized on the  disposition  of the shares)
over the option  exercise  price paid for such  shares,  and (ii) the Company is
entitled  to a tax  deduction  in the  same  amount.  Any  further  gain or loss
realized by the  participant  will be taxed as short-term  or long-term  capital
gain or loss,  as the case may be, and will not result in any  deduction  by the
Company.

         Nonstatutory  Stock Options.  Generally,  with respect to  nonstatutory
stock  options,  (i) no income is  recognized  by the  optionee  at the time the
option is granted; (ii) generally, at exercise, ordinary income is recognized by
the optionee in an amount equal to the  difference  between the option  exercise
price and the fair market value of the shares on the date of  exercise,  and the
Company  is  entitled  to a tax  deduction  in the  same  amount;  and  (iii) at
disposition,  any gain or loss is treated as a capital gain or loss. In the case
of an optionee who is also an employee, any income recognized upon exercise of a
nonstatutory  stock option will constitute  wages for which  withholding will be
required.

     Stock Purchase Rights

         Stock  purchase  rights will  generally  be taxed in the same manner as
nonstatutory  stock options.  However,  restricted stock is generally  purchased
upon the exercise of a stock purchase right. At the time of purchase, restricted
stock is subject to a  "substantial  risk of  forfeiture"  within the meaning of
Section 83 of the Code,  because the Company may  repurchase  the stock when the
purchaser  ceases  to  provide  services  to the  Company.  As a result  of this
substantial risk of forfeiture, the purchaser will not recognize ordinary income
at the time of purchase.  Instead,  the purchaser will recognize ordinary income
on the dates  when the  stock is no  longer  subject  to a  substantial  risk of
forfeiture  (i.e.,  when  the  Company's  right  of  repurchase   lapses).   The
purchaser's  ordinary income is measured as the difference  between the purchase
price and the fair market  value of the stock on the date the stock is no longer
subject to right of repurchase.

         The  purchaser  may  accelerate  to the  date  of  purchase  his or her
recognition  of ordinary  income,  if any,  and begin his or her  capital  gains
holding period by timely filing,  (i.e, within thirty days of the purchase),  an
election  pursuant to Section  83(b) of the Code.  In such event,  the  ordinary
income  recognized,  if any, is measured as the difference  between the purchase
price and the fair market  value of the stock on the date of  purchase,  and the
capital  gain  holding  period  commences  on such  date.  The  ordinary  income
recognized by a purchaser who is an employee will be subject to tax  withholding
by the Company.

                                        7

<PAGE>


     Participation in the Incentive Plan

         The  following  table shows the number of options  granted to the named
groups under the Incentive Plan during the year ended December 31, 1999.


                                  PLAN BENEFITS
                            1998 Incentive Stock Plan


                                                                    Number of
Name and Position (1)                                              Options (2)
- ---------------------                                              -----------
Executive Officers as a Group ................................       639,000
Non-Executive Director Group .................................          --
Non-Executive Officer Employee Group .........................       641,250

- ------------
(1)  The table of option grants under Executive Compensation -- Option Grants in
     Last  Fiscal  Year  appearing  later  in  this  proxy  statement   provides
     information  with  respect to the grant of options to the  Company's  Chief
     Executive Officer and the other Named Officers during the last fiscal year.

(2)  All options  are  granted at no less than fair market  value on the date of
     grant.


Required Vote

         The affirmative  vote of the holders of a majority of the shares of the
Company's  common  stock  voting in person or by proxy on this  proposal  at the
annual meeting is required to approve the amendment to the 1998 Incentive  Stock
Plan.

       THE BOARD OF DIRECTORS RECOMMENDS THAT THE STOCKHOLDERS VOTE "FOR"
           APPROVAL OF THE AMENDMENT TO THE 1998 INCENTIVE STOCK PLAN.


                                 PROPOSAL THREE

            APPROVAL OF AN AMENDMENT TO EMPLOYEE STOCK PURCHASE PLAN

General

         The 1992 Employee  Stock  Purchase Plan (the  "Employee  Stock Purchase
Plan") was  adopted by the board of  directors  and  initially  approved  by the
stockholders  in March 1992. The Employee Stock Purchase Plan permits  employees
to purchase the Company's common stock at a discounted price through accumulated
payroll deductions.

Proposal

         In April 2000,  the board of  directors  approved an  amendment  to the
Employee  Stock  Purchase  Plan to increase  the number of shares  reserved  for
future  issuance by 150,000  shares.  The  stockholders  are being  requested to
approve this amendment to the Employee Stock Purchase Plan.

         As of March 31,  2000,  432,813  shares  had been  purchased  under the
Employee  Stock  Purchase  Plan,  and 67,187 shares remain  available for future
purchase.


                     SUMMARY OF EMPLOYEE STOCK PURCHASE PLAN

     Purpose of the Plan

         The Employee  Stock  Purchase  Plan is designed to encourage and assist
all  employees  of the  Company  to acquire an equity  interest  in the  Company
through the purchase of common  stock.  It is also intended to provide to United
States  employees  participating  in the plan the tax benefits  available  under
Section 421 of the Code.

                                        8

<PAGE>


     Administration

         The  Purchase  Plan may be  administered  by the  board or a  committee
appointed by the board.  All questions of  interpretation  or application of the
Purchase Plan are  determined by the board or its appointed  committee,  and its
decisions are final, conclusive and binding upon all participants.

     Eligibility

         Each employee of the Company  (including  officers) who regularly works
at least 20 hours per week and more than five (5)  months in any  calendar  year
and has been  continuously  employed for at least three (3)  consecutive  months
prior to an Offering Period,  is eligible to participate in the Purchase Plan if
so employed  on the first day of an Offering  Period;  provided,  however,  that
certain  limitations  imposed by Section  423(b) of the Code and  limitations on
stock ownership as set forth in the Purchase Plan may apply.  Eligible employees
become  participants  in  the  Purchase  Plan  by  filing  with  the  Company  a
subscription  agreement authorizing payroll deductions prior to the first day of
each  Offering  Period  unless a  different  time for  filing  the  subscription
agreement has been set by the board.

     Participation in an Offering

         The Purchase Plan has  consecutive and  overlapping  twenty  four-month
offering  periods  that  begin  every six months  (the  "Offering  Periods")  on
February 1 and August 1 of each year.  Each twenty  four-month  Offering  Period
includes four  six-month  purchase  periods (each a "Purchase  Period"),  during
which payroll  deductions are  accumulated  and, at the end of which,  shares of
common stock are purchased with a participant's  accumulated payroll deductions.
The board has the power to change the duration of future  Offering  Periods.  To
participate  in the Purchase Plan, an eligible  employee must authorize  payroll
deductions pursuant to the Purchase Plan. Such payroll deductions may not exceed
ten percent of a participant's  compensation during the Offering Period. Once an
employee  becomes  a  participant  in  the  Purchase  Plan,  the  employee  will
automatically  participate in each successive Offering Period until such time as
the employee withdraws from the Purchase Plan or the employee's  employment with
the  Company  terminates.  At  the  beginning  of  each  Offering  Period,  each
participant  is  automatically  granted  an  option  to  purchase  shares of the
Company's  common stock. The option expires at the end of the Offering Period or
upon  termination of employment,  whichever is earlier,  but is exercised at the
end of each Purchase Period to the extent of the payroll deductions  accumulated
during such Purchase Period.

     Purchase Price, Shares Purchased

         Shares of common  stock may be purchased  under the Purchase  Plan at a
Purchase  Price not less than 85 percent of the lesser of the fair market  value
of the common stock on (i) the first day of the Offering Period or (ii) the last
day of the  Purchase  Period.  The Fair Market  Value of the common stock on any
relevant  date will be the  closing  price per share as  reported  on the Nasdaq
National  Market (or the mean of the closing bid and asked  prices,  if no sales
were  reported)  as quoted  on such  exchange  or  reported  in The Wall  Street
Journal.  The number of shares of common stock a  participant  purchases in each
Offering Period is determined by dividing the total amount of payroll deductions
withheld  from  the  participant's  compensation  prior  to the  last day of the
Purchase Period by the Purchase Price.

     Termination of Employment

         Termination of a  participant's  employment  for any reason,  including
disability  or  death,  or the  failure  of the  participant  to  remain  in the
continuous  scheduled  employ  of the  Company  for at least 20 hours  per week,
cancels his or her option and participation in the Purchase Plan immediately. In
such event, the payroll deductions credited to the participant's account will be
returned  to him or her or,  in the case of  death,  to the  person  or  persons
entitled thereto as provided in the Purchase Plan.

     Adjustments  Upon  Changes  in  Capitalization,  Dissolution,  Liquidation,
     Merger or Asset Sale

     Changes in Capitalization

         Subject to any required action by the stockholders of the Company,  the
number of shares reserved under the Purchase Plan as well as the price per share
of common stock covered by each option under the Purchase Plan which has not yet
been exercised shall be proportionately adjusted for any increase or decrease in
the  number of  issued  shares of common  stock  resulting  from a stock  split,
reverse stock split,

                                        9

<PAGE>


stock  dividend,  combination or  reclassification  of the common stock,  or any
other  increase  or decrease  in the number of shares of common  stock  effected
without  receipt  of  consideration  by the  Company;  provided,  however,  that
conversion of any  convertible  securities of the Company shall not be deemed to
have been "effected without receipt of consideration."  Such adjustment shall be
made by the board, whose  determination in that respect shall be final,  binding
and conclusive.  Except as expressly provided herein, no issuance by the Company
of shares of stock of any class, or securities  convertible into shares of stock
of any class,  shall affect,  and no adjustment by reason  thereof shall be made
with  respect  to, the number or price of shares of common  stock  subject to an
option.

     Dissolution or Liquidation

         In the event of the proposed dissolution or liquidation of the Company,
any Offering Period will terminate immediately prior to the consummation of such
proposed action, unless otherwise provided by the board.

     Merger or Asset Sale

         In the  event of any  merger or sale of  assets  of the  Company,  each
option under the Purchase Plan shall be assumed or an equivalent option shall be
substituted  by such  successor  corporation  or a parent or  subsidiary of such
successor corporation.  In the event the successor corporation refuses to assume
or substitute for the options,  the board shall shorten any Purchase Periods and
Offering  Periods  then in  progress  by setting a new  Exercise  Date (the "New
Exercise Date") and any Offering Periods shall end on the New Exercise Date. The
New Exercise Date shall be prior to the merger,  consolidation or asset sale. If
the board shortens any Purchase  Periods and Offering  Periods then in progress,
the board shall notify each  participant in writing,  at least ten (10) business
days prior to the New Exercise Date,  that the Exercise Date has been changed to
the New Exercise Date and that the option will be exercised automatically on the
New  Exercise  Date,  unless the  participant  has  already  withdrawn  from the
Offering Period.

     Amendment and Termination of the Plan

         The board of directors may at any time  terminate or amend the Purchase
Plan. An Offering  Period may be terminated by the board of directors at the end
of any Purchase Period if the board  determines that termination of the Purchase
Plan is in the best interests of the Company and its stockholders. Generally, no
such termination can affect options  previously  granted.  No amendment shall be
effective  unless it is  approved by the holders of a majority of the votes cast
at a duly  held  meeting  of  stockholders,  if  such  amendment  would  require
stockholder  approval  in order to comply  with  Section  423 of the  Code.  The
Purchase Plan will terminate in 2002.

     Withdrawal

         Generally,  a participant  may withdraw from an Offering  Period at any
time by written notice without  affecting his or her  eligibility to participate
in  future  Offering  Periods.  However,  once a  participant  withdraws  from a
particular  Offering Period,  that participant may not participate  again in the
same Offering  Period.  To  participate  in a subsequent  Offering  Period,  the
participant must deliver to the Company a new subscription agreement.

     Federal Tax Information for Purchase Plan

         The Purchase  Plan,  and the right of  participants  to make  purchases
thereunder,  is intended to qualify under the provisions of Sections 421 and 423
of the Code. Under these provisions,  no income will be taxable to a participant
until  the  shares  purchased  under  the  Purchase  Plan are sold or  otherwise
disposed of. Upon sale or other disposition of the shares,  the participant will
generally  be  subject  to tax and the  amount of the tax will  depend  upon the
holding  period.  If the shares are sold or otherwise  disposed of more than two
(2) years  from the first day of the  Offering  Period and one (1) year from the
date of purchase, the participant will recognize ordinary income measured as the
lesser of (i) the excess of the fair  market  value of the shares at the time of
such sale or disposition  over the purchase price, or (ii) an amount equal to 15
percent  of the fair  market  value of the  shares  as of the  first  day of the
Offering Period.  Any additional gain will be treated as long-term capital gain.
If the shares are sold or otherwise  disposed of before the  expiration  of this
holding period, the participant will recognize ordinary income generally

                                       10

<PAGE>


measured  as the excess of the fair  market  value of the shares on the date the
shares are purchased over the purchase  price.  Any  additional  gain or loss on
such sale or disposition will be a long-term or short-term capital gain or loss,
depending on the holding period.  The Company is not entitled to a deduction for
amounts taxed as ordinary income or capital gain to a participant  except to the
extent of ordinary income  recognized by participants upon a sale or disposition
of shares prior to the expiration of the holding period(s) described above.

         The  foregoing  is only a  summary  of the  effect  of  federal  income
taxation  upon the  participant  and the  Company  with  respect  to the  shares
purchased  under the Purchase Plan.  Reference  should be made to the applicable
provisions  of the Code.  In  addition,  the  summary  does not  discuss the tax
consequences  of a  participant's  death or the  income tax laws of any state or
foreign country in which the participant may reside.

     Participation in the Employee Stock Purchase Plan

         The  following  table  shows the  "Dollar  Value"  and number of shares
applicable to the named  individuals  and groups under the 1992  Employee  Stock
Purchase  Plan during the year ended  December 31, 1999 and the purchase  period
ending January 31, 2000.  The "Dollar Value" is the difference  between the fair
market value of the common stock on the dates of purchase and the  participant's
purchase price.


<TABLE>
                                                            PLAN BENEFIT
                                                  1992 Employee Stock Purchase Plan

<CAPTION>
                                                                                                         Dollar           Number
Name and Position                                                                                       Value ($)      of Shares (#)
- -----------------                                                                                       ---------      -------------
<S>                                                                                                      <C>               <C>
Stephen A. Sherwin, M.D ..............................................................................      821               812
     Chairman, President and Chief Executive Officer
Dale G. Ando, M.D ....................................................................................    1,720             1,984
     Vice President, Clinical Research & Regulatory Affairs
David F. Broad, Ph.D .................................................................................      977             1,126
     Vice President, Development & Manufacturing
Bruce A. Hironaka ....................................................................................    4,111             4,074
     Vice President, Corporate Development
Christine McKinley ...................................................................................     --                --
     Vice President, Human Resources
Executive Officers as a Group ........................................................................   10,359            10,729
Non-Executive Director Group (1) .....................................................................     --                --
Non-Executive Officer Employee Group .................................................................   65,752            67,505

<FN>
- ------------
(1)  Members of the board of directors  are  ineligible to  participate  in this
Plan, unless they are also employees of the Company.
</FN>
</TABLE>


Required Vote

         The  affirmative  vote of a  majority  of the  shares of the  Company's
common stock voting in person or by proxy on this proposal at the annual meeting
is required to approve the amendment to the 1992 Employee Stock Purchase Plan.

        THEBOARD OF DIRECTORS RECOMMENDS THAT THE STOCKHOLDERS VOTE "FOR"
         APPROVAL OF THE AMENDMENT TO THE EMPLOYEE STOCK PURCHASE PLAN.

                                       11

<PAGE>


                                  PROPOSAL FOUR

              RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS

         The board of  directors  has  selected  Ernst & Young LLP,  independent
auditors,  to audit the financial  statements of the Company for the fiscal year
ending December 31, 2000. Ernst & Young LLP has audited the Company's  financial
statements  since the year ended December 31, 1989.  Representatives  of Ernst &
Young LLP are expected to be present at the meeting with the opportunity to make
a statement if they desire to do so, and are expected to be available to respond
to appropriate questions.

Required Vote

         The affirmative  vote of the holders of a majority of the shares of the
Company's  common  stock  voting in person or by proxy on this  proposal  at the
annual  meeting  is  required  to approve  the  appointment  of the  independent
auditors.

     THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THE RATIFICATION OF THE
            APPOINTMENT OF ERNST & YOUNG LLP AS INDEPENDENT AUDITORS.


                                OTHER INFORMATION

Stock Ownership of Principal Stockholders and Management

         The following table sets forth the beneficial ownership of common stock
of the Company as of March 31, 2000 by: (a) each person known to the Company who
beneficially  owns five percent or more of the outstanding  shares of its common
stock;  (b) each  director;  (c)  each of the  executive  officers  named in the
Summary  Compensation  Table below; and (d) all directors and executive officers
as a group:




<TABLE>
<CAPTION>
                                                          Shares                 Percentage(%)
Name and Address of Beneficial Owner              Beneficially Owned (1)     Beneficially Owned (2)
- -----------------------------------------------   ------------------------   ------------------------
<S>                                                      <C>                          <C>
Aventis Pharmaceuticals Inc. (3) ......................  1,900,000                    5.53
     9300 Ward Parkway
     Kansas City, MO 64114
David W. Carter (4) ...................................     22,500                    *
James M. Gower (5) ....................................     51,250                    *
Joseph E. Maroun (6) ..................................     64,700                    *
John T. Potts, Jr., M.D. (7) ..........................     30,000                    *
Stephen A. Sherwin, M.D. (8) ..........................    930,658                    2.72
Eugene L. Step (9) ....................................     83,500                    *
Inder M. Verma, Ph.D. (10) ............................     68,500                    *
Dale G. Ando, M.D. (11) ...............................     94,738
David F. Broad, Ph.D. (12) ............................      7,031                    *
Bruce A. Hironaka (13) ................................     36,608                    *
Christine McKinley (14) ...............................     92,898                    *
All executive officers and directors as a group
     (13 persons) (15) ................................  1,443,883                    4.13
<FN>
- ------------
  * Less than 1 percent

 (1) Beneficial  ownership is  determined  in  accordance  with the rules of the
     Securities  and  Exchange  Commission  and  generally  includes  voting  or
     investment  power  with  respect  to  securities.  Except as  indicated  by
     footnote,  and subject to community  property  laws where  applicable,  the
     persons named in the table,  to the Company's  knowledge,  have sole voting
     and  investment  power with  respect to all shares of common stock shown as
     beneficially owned by them.


                                       12


<PAGE>

 (2) Percentage of beneficial  ownership is based on 33,586,229 shares of common
     stock  outstanding as of March 31, 2000.  Shares of common stock subject to
     options or warrants currently  exercisable,  or exercisable within 60 days,
     are deemed  outstanding  for computing the percentage of the person holding
     such options but are not deemed outstanding for computing the percentage of
     any other person.

 (3) Includes 750,000 shares subject to a warrant that is exercisable at $13 per
     share.

 (4) Consists of 22,500 shares subject to options that are exercisable within 60
     days after March 31, 2000.

 (5) Consists of 51,250 shares subject to options that are exercisable within 60
     days after March 31, 2000.

 (6) Includes  52,500 shares subject to options that are  exercisable  within 60
     days after March 31, 2000.

 (7) Consists of 30,000 shares subject to options that are exercisable within 60
     days after March 31, 2000.

 (8) Includes  625,250 shares subject to options that are exercisable  within 60
     days after March 31, 2000.  Additionally,  includes  30,000  shares held in
     irrevocable trust for Dr. Sherwin's child for which he disclaims beneficial
     ownership.

 (9) Consists of 83,500 shares subject to options that are exercisable within 60
     days after March 31, 2000.

(10) Consists of 30,000 shares subject to options that are exercisable within 60
     days after March 31, 2000.

(11) Includes  94,738 shares subject to options that are  exercisable  within 60
     days after March 31, 2000.

(12) Includes  7,031 shares  subject to options that are  exercisable  within 60
     days after March 31, 2000.

(13) Consists of 36,608 shares subject to options that are exercisable within 60
     days after March 31, 2000.

(14) Consists of 92,898 shares subject to options that are exercisable within 60
     days after March 31, 2000.

(15) Includes 1,410,211 shares subject to options that are exercisable within 60
     days after March 31, 2000.
</FN>
</TABLE>

                                       13


<PAGE>

                             EXECUTIVE COMPENSATION

     The  following  table  sets  forth  certain   information   concerning  the
compensation of the Company's  chief  executive  officer ("CEO") and each of the
four other most highly compensated executive officers (collectively,  the "Named
Officers")  for  services in all  capacities  as officers to the Company  during
fiscal years 1997, 1998 and 1999.

<TABLE>
Summary Compensation Table
<CAPTION>
                                                                                         Long-Term
                                                                                        Compensation
                                                                                 ----------------------------
                                                  Annual Compensation                    Securities
                                          ------------------------------------           Underlying
Name and Principal Position               Year     Salary($)     Bonus($)(1)           Options(3)(2)
- ---------------------------------------   ------   -----------   -------------   ----------------------------
<S>                                       <C>       <C>            <C>                 <C>
Stephen A. Sherwin, M.D. ..............   1999      395,000        170,000             100,000(3)
 Chairman, President and                                                                70,000(4)
 Chief Executive Officer                  1998      378,525        100,000             250,000(5)
                                                                                       250,000(6)
                                          1997      360,500                             60,000
                                                                                       160,000(6)

Dale G. Ando, M.D. ....................   1999      205,000         49,500              22,500(3)
 Vice President,                                                                        22,500(4)
 Clinical Research & Regulatory Affairs   1998      181,000         29,000              22,500
                                                                                       122,500(6)
                                          1997       80,881                            100,000(7)

David F. Broad, Ph.D. .................   1999      188,000         45,000              22,500(3)
 Vice President,                                                                        22,500(4)
 Development & Manufacturing              1998      180,000         29,000              45,000
                                                                                       117,000(6)
                                          1997      168,500                             45,000
                                                                                        57,000(6)

Bruce A. Hironaka .....................   1999      200,000         56,000              30,000(3)
 Vice President,                                                                        25,000(4)
 Corporate Development                    1998      187,500         47,000              45,000
                                                                                       136,575(6)
                                          1997      172,375                             45,000
                                                                                        61,575(6)

Christine McKinley ....................   1999      164,000         46,000              22,500(3)
 Vice President,                                                                        25,000(4)
 Human Resources                          1998      157,000         29,000              45,000
                                                                                       142,700(6)
                                          1997      150,800                             45,000
                                                                                        57,700(6)
<FN>
- ------------

(1) These  bonuses,  which were awarded for and accrued in the year noted,  were
    paid in the subsequent year.

(2) Cell Genesys has no restricted stock awards,  stock  appreciation  rights or
    long-term incentive plan payouts.

(3) Consists of options granted 2/2/1999, related to performance during 1998.

(4) Consists of options granted 12/9/1999, related to performance during 1999.

(5) Of the options held by Dr. Sherwin, 250,000 were excluded from repricing and
    were  retained  at their  original  option  price  which is higher  than the
    repriced options discussed in note (6) below.


                                       14


<PAGE>

(6) During  1997  and  1998,  a  majority  of  employees,   including  officers,
    surrendered and cancelled certain previously granted options in exchange for
    new options at a revised price. See also  "Compensation  Committee Report on
    Executive Compensation".

(7)  Dr. Ando joined the company as Vice  President,  Clinical  Research on July
     15, 1997.


Option Grants in Last Fiscal Year

     The  following  table sets  forth each grant of stock  options to the Named
Officers in fiscal year 1999:
</FN>
</TABLE>



<TABLE>
<CAPTION>

                                                               Value at Assumed                      Potential Realizable
                                                               Individual Grants                        Annual Rates of
                                                       --------------------------------                   Stock Price
                                                        Percent of Total                                 Appreciation
                                       Number of            Options                                    for Option Term
                                       Securities          Granted to       Exercise                         ($)(3)
                                       Underlying          Employees         Price $     Expiration  ---------------------
Name                               Options Granted(1)    in 1999 (%)(2)    (per share)      Date        5%         10%
- --------------------------------- -------------------- ------------------ ------------- ------------ --------- -----------
<S>                                      <C>                  <C>             <C>         <C>         <C>       <C>
Stephen A. Sherwin, M.D. ........        100,000(4)           7.8             5.875       02/02/09    369,476     936,324
                                          70,000(5)           5.4             9.500       12/09/09    418,215   1,059,839
Dale G. Ando, M.D. ..............         22,500(4)           1.7             5.875       02/02/09     83,132     210,673
                                          22,500(5)           1.7             9.500       12/09/09    134,426     340,662
David F. Broad, Ph.D. ...........         22,500(4)           1.7             5.875       02/02/09     83,132     210,673
                                          22,500(5)           1.7             9.500       12/09/09    134,426     340,662
Bruce A. Hironka ................         30,000(4)           2.3             5.875       02/02/09    110,843     280,897
                                          25,000(5)           1.9             9.500       12/09/09    149,362     378,514
Christine McKinley ..............         22,500(4)           1.7             5.875       02/02/09     83,132     210,673
                                          25,000(5)           1.9             9.500       12/09/09    149,362     378,514
<FN>
- ------------

(1) Options  granted under the  Incentive  Plan have a maximum term of ten years
    but may be terminated  earlier upon  termination of employment.  Shares vest
    over a four-year period at the rate of 1/48th per month.

(2) Based on an aggregate of 1,286,250 options granted to employees in 1999.

(3) The potential  realizable  value is calculated based on the ten-year term of
    the option  and the fair  market  value of the common  stock at the time the
    option was granted,  compounded  annually.  The five percent and ten percent
    assumed  annualized rates of compound stock price  appreciation are provided
    in  compliance  with the rules of the SEC and are not meant to represent the
    Company's  estimate or a  projection  by the Company of future  common stock
    prices.

(4) Consists of options granted 2/2/1999, related to performance during 1998.

(5) Consists of options granted 12/9/1999, related to performance during 1999.
</FN>
</TABLE>

                                       15

<PAGE>

Aggregated  Option  Exercises  in Last  Fiscal  Year and Fiscal  Year End Option
Values

<TABLE>
     The  following  table  sets forth  certain  information  concerning  option
exercises  in 1999 and  unexercised  options held as of December 31, 1999 by the
Named Officers.

<CAPTION>
                                                                     Number of Securities         Value of Unexercised
                                   Shares                           Underlying Unexercised            In-the-money
                                  Acquired                         Options at Dec. 31, 1999     Options at Dec. 31, 1999
                                     on             Value                Exercisable/                 Exercisable/
Name                              Exercise     Realized ($)(1)          Unexercisable             Unexercisable ($)(2)
- --------------------------------- ----------   -----------------   --------------------------   --------------------------
<S>                                 <C>             <C>              <C>                         <C>
Stephen A. Sherwin, M.D. ........     --               --             575,250 / 285,000          4,833,366 / 1,539,518
Dale G. Ando, M.D. ..............     --               --              77,290 /  90,210            661,652 /   633,276
David F. Broad, Ph.D. ...........     --               --              88,876 /  73,124            762,311 /   484,833
Bruce A. Hironaka ...............   5,000           46,563            105,324 /  81,251            901,930 /   532,159
Christine McKinley ..............     --               --             114,576 /  75,624            985,593 /   493,115
<FN>
- ------------
(1) Fair market of the underlying  securities minus the aggregate exercise price
    of the option.

(2) Fair market value of the underlying securities at December 31, 1999 less the
    exercise price, based on a closing stock price of $12.813.
</FN>
</TABLE>


Compensation of Directors

     Beginning July 1, 1995,  non-employee  directors became eligible to receive
for their  services as  directors of the Company a $15,000  annual  retainer and
$1,000 fee for each board meeting  attended as well as reimbursement of expenses
incurred in attending board meetings. In addition, the Company has traditionally
granted 30,000 shares of common stock,  vesting ratably over 48 months,  to each
non-employee  director  (currently  six  persons)  every  four  years on the day
following  the annual  meeting of  stockholders  beginning  with the 1995 annual
meeting.  The exercise price of all options  granted is the fair market value at
the time of grant.  In  addition,  Dr.  Potts and Dr.  Verma  also  serve on the
Company's  Scientific  Advisory Board. The Company provides a stock option grant
of 10,000 shares, vesting ratably over 48 months, to each non-employee member of
the Scientific Advisory Board.

Employment Contracts and Change of Control Agreements

     Since the time of his initial  employment  in March  1990,  the Company has
agreed to maintain Dr. Sherwin's  salary for twelve months after  termination of
his employment with the Company,  unless the Company  terminates Dr. Sherwin for
cause or he terminates his employment voluntarily.

     The  Company  has  implemented  change in control  agreements  for  certain
executive officers.  Under these agreements,  the Company has agreed to provide:
Dale G.  Ando,  M.D.,  David  F.  Broad,  Ph.D.,  Bruce A.  Hironaka,  Christine
McKinley,  Matthew  J.  Pfeffer  and Joseph J.  Vallner,  Ph.D.  with  severance
payments in an  aggregate  amount equal to twelve  months  salary plus bonus and
certain  employee  benefits,  following  a change in control of the  Company and
termination without cause by the company or upon constructive termination.  Also
under a similar change of control  agreement,  the Company has agreed to provide
Dr.  Sherwin with severance  payments in an aggregate  amount equal to two years
salary  plus bonus and certain  employee  benefits.  Included  in Dr.  Sherwin's
change in control  agreement  is a  provision  for  payments  by the  Company of
certain  taxes that may be  incurred  as a  consequence  of the  agreement.  Dr.
Sherwin's  change of control  agreement,  when  applicable,  will  supersede his
employment contract.


                                       16


<PAGE>

                              CERTAIN TRANSACTIONS

     In September  1996,  while a director of Somatix Therapy  Corporation,  Dr.
Verma  received a $400,000 loan from  Somatix,  secured by his shares of Somatix
common stock. Cell Genesys assumed Dr. Verma's loan following its acquisition of
Somatix. Dr. Verma's shares of common stock in Cell Genesys now secure the loan.
The loan bears  interest at 8.5 percent per annum and is due and payable in full
on September 1, 2001. As of December 31, 1999,  the  outstanding  balance of the
loan was $300,000.

     The  Company  retains  certain   directors  under   scientific   consulting
agreements.  During 1999, Dr. Verma earned $100,000 of which $25,500 was applied
to the payment of interest on his loan from the Company, described above.



            COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

     Decisions  regarding  compensation of the Company's  executive officers are
made by the Cell  Genesys  compensation  committee  of the  board of  directors.
During 1999,  the  compensation  committee  was  comprised  of two  non-employee
directors, Messrs. Gower and Step. The compensation committee is responsible for
setting  compensation  policy and  determining  the annual  compensation  of the
executive officers of Cell Genesys,  including base salaries,  bonuses,  if any,
and stock options.  Cell Genesys' executive pay programs are designed to attract
and retain executives who will contribute to Cell Genesys' long-term success, to
reward executives for achieving both short- and long-term goals of Cell Genesys,
to link executive and stockholder  interests through  equity-based  compensation
plans,  and to provide a compensation  package that  recognizes  both individual
contributions and company performance. A substantial portion of each executive's
total  compensation  is  intended  to be  variable  and  to  relate  to,  and be
contingent  upon,   performance.   The  compensation   committee  evaluates  the
performance and determines the  compensation of the chief executive  officer and
other  executive  officers  of Cell  Genesys  annually,  based  upon  individual
performance and the achievement of corporate goals.


General Compensation Policy

     Cell Genesys'  executive  compensation  programs seek to accomplish several
major goals:

   * To recruit  and retain  highly  qualified  executive  officers  by offering
     overall  compensation  that is competitive with that offered for comparable
     positions in companies in the biotechnology industry of comparable size and
     at a comparable stage of development.

   * To  motivate  executives  to achieve  important  business  and  performance
     objectives and to reward them when such objectives are met; and

   * To align the interests of executive  officers with the long-term  interests
     of stockholders through participation in the Company's stock option plan.

     The achievement of these goals is based on a mix of compensation  elements,
as described below:


Base Salary

     Base  salaries  for  all  employees,   including  executive  officers,  are
determined  based on an established job grade and salary matrix that is designed
to provide a base salary  that is  competitive  with  comparable  companies.  In
monitoring the job grade and salary matrix, the compensation  committee compares
compensation  information derived from surveys including compensation levels for
companies of similar size and stage of  development.  Included in the survey are
some of the  companies  included in the Nasdaq  Pharmaceutical  Index,  with the
primary focus on biotechnology companies at a similar stage in the San Francisco
Bay Area  which may  compete  for the same  pool of  employees.  The  assessment
confirmed  that Cell Genesys' base  compensation  was comparable to the industry
averages.

     Adjustments to each individual's base salary, including executive officers,
are made in  connection  with annual  performance  reviews.  The amounts of such
increases are calculated using merit increase guidelines based on the employee's
position within the relevant compensation range and the results of


                                       17


<PAGE>

their  performance  review.  The recommended  percentage  increases are adjusted
annually to reflect  the  compensation  committee's  assessment  of  appropriate
salary adjustments given the results of competitive surveys and general economic
conditions.


Performance Based Incentive Plan

     Officers and certain other  employees  may earn an annual  bonus,  set as a
percentage of base salary, based on the achievement of individual objectives and
corporate  goals.  Corporate  goals are established at the start of each year in
conjunction  with the  compensation  committee  and the full board of directors.
Awards made to executive  officers are based upon the  achievement  of corporate
goals as well as the department  goals of the individual  officers.  These goals
may include progress made in preclinical programs and clinical trials, strategic
alliances,  financing activities and the financial results of Cell Genesys. Cell
Genesys'  compensation  policy with respect to annual bonus was also compared to
relevant market data and found to be comparable to industry averages.  From time
to time the  compensation  committee may elect to defer an annual cash bonus and
employ  increased  stock based  compensation  in order to conserve the Company's
financial  resources  and retain key  employees  and align the  interests of the
employees with those of the stockholders.


Stock-Based Incentive Compensation

     Stock options  enable Cell Genesys to provide  long-term  incentives to its
employees,  which align the interests of all employees,  including the executive
officers, with those of the stockholders.  Options are exercisable in the future
at the fair  market  value at the time of  grant,  so that an  option  holder is
rewarded  only by the  appreciation  in price of the Cell Genesys  common stock.
Stock options are granted upon  commencement  of employment and generally have a
four-year vesting period and expire ten years after the date of grant.  Periodic
grants of stock  options are generally  made annually to all eligible  employees
based on performance, with additional grants made to certain employees following
a significant change in job responsibility,  scope or title.  Guidelines for the
number of options  granted  to each  eligible  employee  are  determined  by the
compensation committee based on several factors,  including a valuation analysis
reflecting market-based  compensation,  salary grade and the performance of each
participant. The size of the resulting grants developed under this procedure are
targeted to be at or above competitive  levels as a reflection of both providing
an incentive for  favorable  performance  of Cell  Genesys,  as well as the risk
attached to the future growth of the biotechnology industry.


CEO Compensation

     Dr.  Sherwin's   compensation  for  fiscal  1999  is  consistent  with  the
compensation  policy  of Cell  Genesys  described  above  and  the  compensation
committee's  evaluation of his overall  leadership and management of the company
for the year.  During  1999,  Cell  Genesys  made  significant  progress in both
product development and business activities. Under Dr. Sherwin's leadership, the
Company completed  initial studies of its lead programs,  GVAX(R) cancer vaccine
for  prostate  cancer  and  lung  cancer  and  reported   positive  results  for
preclinical studies of gene therapies for hemophilia and other indications.  The
completion of the GVAX(R)  clinical trials with  encouraging  results led to the
initiation of new multicenter  trials in both indications and also triggered the
payment of significant  financial  milestones under our worldwide  collaboration
with the  pharmaceutical  division  of Japan  Tobacco.  As a result of these and
other financial  payments,  Cell Genesys recorded its fourth consecutive year of
revenue  growth in 1999,  and ended the year with over $50  million  in cash and
short term investments.  Additionally,  in early 2000 through participation in a
secondary  stock offering of its former  subsidiary,  Abgenix,  Cell Genesys was
able to  raise an  additional  $194  million  in net cash  with no  dilution  to
existing  shareholders.  These  substantial  financial  resources  position Cell
Genesys  to  execute  on its  existing  programs  and  take  advantage  of other
opportunities  which may  arise,  including  the  potential  acquisition  of new
products and technologies.

     Cell  Genesys  ended 1999  financially  strong and well  positioned  in its
field.  Throughout  the past year, Dr. Sherwin has continued to ensure that Cell
Genesys'  assets are  utilized  effectively  and to their best  advantage  while
continuing to optimally manage Cell Genesys' financial resources.  Dr. Sherwin's
compensation  during  1999  reflects  his  leadership  and  management  and  the
achievements of Cell Genesys during the past year.


                                       18


<PAGE>

Compliance with Internal Revenue Code Section 162(m)

     As a result of  Section  162(m) of the  Internal  Revenue  Code,  which was
enacted  into  law in  1993,  the  Company  may not take a  federal  income  tax
deduction for compensation  paid to certain  executive  officers,  to the extent
that  compensation  exceeds  $1  million  per  officer  in any  one  year.  This
limitation  became effective for each year beginning after December 31, 1993 and
applies to all compensation paid to the covered executive  officers which is not
considered  to  be   performance-based.   Compensation   that  does  qualify  as
performance-based  compensation  will  not  have to be taken  into  account  for
purposes of this limitation.

     The cash compensation paid to the Company's  executive officers during 1999
did not exceed the $1 million limit per officer, nor is the cash compensation to
be paid to the  Company's  executive  officers  for 2000  expected to reach that
level.  Because it is unlikely that the cash compensation  payable to any of the
Company's  executive  officers in the  foreseeable  future will  approach the $1
million  limitation,  the  compensation  committee  has  decided not to take any
action at this time to limit or  restructure  the elements of cash  compensation
payable to the Company's executive officers.  The Committee will reconsider this
decision  should the  individual  compensation  of any  executive  officer  ever
approach the $1 million level.

     The foregoing  report has been submitted by the undersigned in our capacity
as members of the compensation committee of the Company's board of directors.


                                        Members of the Compensation Committee
                                        James M. Gower
                                        Eugene L. Step


                                       19


<PAGE>

                             STOCK PERFORMANCE GRAPH


Stockholder Return Comparison
     The graph below  compares  the  cumulative  total  return on the  Company's
common  stock for fiscal  years 1995 to 1999  compared to the CRSP Total  Return
Index for the Nasdaq National Market (U.S.  companies) and the CRSP Total Return
Index  for  the  Nasdaq   Pharmaceutical  Stocks  (SIC  283).  The  stock  price
performance  shown on the graph below is not  necessarily  indicative  of future
price performance.

[The following  descriptive  data is supplied in accordance  with Rule 304(d) of
Regulation S-T]

                 Comparison of Cumulative Stockholder Return*

                               [GRAPHIC OMITTED]

* Assumes $100 invested on December 31, 1994 in the  Company's  common stock and
  in each index listed above.  The total return for the  Company's  common stock
  and the  indices  used  assumes the  reinvestment  of  dividends,  even though
  dividends have never been declared on the Company's common stock.


Compliance with Section 16(a) of the Exchange Act
     Section 16(a) of the Exchange Act requires the Company's executive officers
and directors and persons who own more than ten percent of a registered class of
the  Company's  equity  securities,  to file with the  Securities  and  Exchange
Commission  (the "SEC")  initial  reports of ownership and reports of changes in
ownership of common stock and other equity securities of the Company.  Executive
officers,  directors and ten percent stockholders are required by SEC regulation
to furnish the Company with copies of all Section 16(a) forms they file.


                                       20


<PAGE>

                                  OTHER MATTERS

     The  Company  knows of no  other  matters  to be  submitted  at the  annual
meeting.  If any other  matters  properly  come  before the  meeting,  it is the
intention  of the persons  named in the  enclosed  proxy to vote the shares they
represent as the board of directors may recommend.

     It is important that your shares be represented at the meeting,  regardless
of the number of shares,  which you hold.  Please  complete,  date,  execute and
return,  at  your  earliest  convenience,  the  accompanying  proxy  card in the
envelope, which has been enclosed.


                                        THE BOARD OF DIRECTORS
                                        Dated: April 28, 2000

                                       21


<PAGE>

                                                                      APPENDIX A


                                  DETACH HERE
- --------------------------------------------------------------------------------

          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

                               CELL GENESYS, INC.

                      2000 ANNUAL MEETING OF STOCKHOLDERS

                                  JUNE 8, 2000


         The  undersigned   stockholders  of  Cell  Genesys,  Inc.,  a  Delaware
corporation,  hereby  acknowledges  receipt of the  Notice of Annual  Meeting of
Stockholders and Proxy Statement, each dated April 28, 2000, and hereby appoints
Stephen A. Sherwin,  M.D. and Matthew J. Pfeffer,  and each of them, proxies and
attorneys-in-fact, with full power to each of substitution, on behalf and in the
name of the undersigned, to represent the undersigned at the 2000 Annual Meeting
of Stockholders of Cell Genesys,  Inc. to be held on June 8, 2000 at 10:00 a.m.,
local  time,  at  342  Lakeside  Drive,  Foster  City,  CA  94404,  and  at  any
adjournments  thereof,  and to  vote  all  shares  of  Common  Stock  which  the
undersigned is entitled to vote on the matters set forth on the reverse side.

- -----------                                                          -----------
SEE REVERSE                                                          SEE REVERSE
   SIDE            CONTINUED AND TO BE SIGNED ON REVERSE SIDE            SIDE
- -----------                                                          -----------


<PAGE>


[X] Please mark
    votes as in
    this example.

1. ELECTION OF DIRECTORS:

   Nominees: (01) David W. Carter; (02) James M. Gower; (03) John T.
   Potts, Jr., M.D.; (04) Stephen A. Sherwin, M.D.; (05) Eugene L. Step;
   (06) Inder M. Verma, Ph.D.

                         FOR          WITHHELD

                         [ ]             [ ]

[ ] _______________________________________
    For all nominees except as noted above



                                                       FOR    AGAINST    ABSTAIN
2.   Approve an increase in the number of shares
     reserved for issuance in the Company              [ ]      [ ]        [ ]
     Incentive Stock Plan.

3.   Approve an increase in the number of shares
     reserved for issuance in the Company Employee     [ ]      [ ]        [ ]
     Stock Purchase Plan.

4.   Proposal to ratify the appointment of Ernst
     & Young LLP as independent auditors for the       [ ]      [ ]        [ ]
     2000 fiscal year.


                           MARK HERE FOR ADDRESS CHANGE AND NOTE AT LEFT   [ ]

Please sign the proxy  exactly as your name(s)  appear(s)  hereon.  Joint owners
should sign personally. An attorney, administrator,  trustee, executor, guardian
or other person signing in a representative capacity should indicate the name of
the corporation and such officer's capacity.


Signature: __________________________________________ Date: ____________________

Signature: __________________________________________ Date: ____________________



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