NEUROMEDICAL SYSTEMS INC
DEF 14A, 1998-04-07
TESTING LABORATORIES
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<PAGE>
 
                            SCHEDULE 14A INFORMATION
 Proxy Information Pursuant to Section 14(A) of the Securities Exchange Act of
                                      1934

AMENDMENT NO.
Filed by the Registrant  (X)
Filed by a Party other than the Registrant ( )
Check the appropriate box:

( ) Preliminary Proxy Statement  ( )  Confidential, for Use of the Commission
Only (as permitted by Rule 14a-6(e) (2))

(X) Definitive Proxy Statement

( ) Definitive Additional Materials

( ) Soliciting Materials Pursuant to (S) 240.14a-11(c) or (S) 240.14a-12

NEUROMEDICAL SYSTEMS, INC.
- --------------------------
(NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

(Name of Person(s) Filing Proxy Statement if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

(X) No fee required

( ) $125 per Exchange Act Rules 0-11(c)(1)(ii), 14a-6(i)(1), or 14a-6(i)(2) or
Item 22(a) (2) of Schedule 14A
( ) $500 per each party to the controversy pursuant to Exchange Act Rule 14a-
6(i)(3).
( ) Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

(1)  Title of each class of securities to which transaction applies:
(2)  Aggregate number of securities to which transaction applies:

(3)  Per unit price or other underlying value of transaction computed pursuant
to Exchange Act Rule 0-11:(1) (Set forth the amount on which the filing fee is
calculated and state how it was determined);

(4)  Proposed maximum aggregate value of transaction.
(5)  Total fee paid.

( ) Fee Paid previously with preliminary materials.

( ) Check box if any part of the fee is offset as provided by Exchange Act Rule
0-11(a)(2) and identify the filing for which the offsetting fee was paid
previously.  Identify the previous filing by registration statement number, or
the Form or Schedule and the date of its filing.

(1) Amount Previously Paid:
(2) Form, Schedule or Registration Statement No.:
(3) Filing Party:
(4) Date Filed:
<PAGE>
 
                                  [NSI LOGO]

                          NEUROMEDICAL SYSTEMS, INC.
                    Focusing Intelligent Vision on Medicine


Office of C. Raymond Larkin, Jr.
Chairman of the Board of Directors

April 7, 1998

Dear Stockholder:

You are cordially invited to attend the 1998 Annual Meeting of Stockholders of
Neuromedical Systems, Inc. to be held on Thursday, May 7, 1998 at 10:00 A.M.
(Eastern standard time) at the Holiday Inn, Suffern, New York.

At this year's meeting, you will be asked to elect two directors and to ratify
the selection of the independent auditors.  The Secretary's formal notice of the
Annual Meeting and the Company's Proxy Statement appear on the following pages
and describe the matters to be acted upon at the Annual Meeting.  We urge you to
read this information carefully.  Your Board of Directors unanimously believes
that election of its nominees as directors, and ratification of its selection of
independent auditors are in the best interests of the Company and its
stockholders and therefore recommends a vote FOR items 1 and 2 on the enclosed
proxy card.

During the Annual Meeting, we will review Company developments over the past
year and respond to comments and questions from stockholders.

I personally encourage you to attend the Annual Meeting and I look forward to
greeting you there.  The Annual Meeting is an excellent opportunity to discuss
the Company's activities with you in person.  If you cannot attend, please be
sure to vote your preferences on the enclosed proxy card and return it promptly.
Returning the proxy card will not prevent you from voting in person but will
assure that your vote is counted if you are unable to attend the Annual Meeting.

IT IS IMPORTANT THAT YOUR SHARES OF COMPANY COMMON STOCK BE REPRESENTED AND
VOTED WHETHER OR NOT YOU ATTEND THE ANNUAL MEETING.  THEREFORE, PLEASE COMPLETE,
SIGN, DATE AND PROMPTLY RETURN THE ENCLOSED PROXY CARD IN THE ACCOMPANYING
PREPAID ENVELOPE.  THANK YOU VERY MUCH.

Sincerely,



C. Raymond Larkin, Jr.
Chairman of the Board
<PAGE>
 
                          NEUROMEDICAL SYSTEMS, INC.
             Two Executive Boulevard, Suffern, New York 10901-4164

                              -------------------

                                PROXY STATEMENT

                              -------------------

This Proxy Statement is furnished in connection with the solicitation of proxies
by the Board of Directors (the "Board of Directors" or the "Board") of
Neuromedical Systems, Inc. (the "Company").  The proxies will be voted at the
Annual Meeting of Stockholders of the Company on May 7, 1998 (the "Annual
Meeting") and any adjournments or postponements thereof.  Only holders of
Company common stock, par value $.0001 per share (the "Common Stock"), held of
record at the close of business at 5:00 P.M., Eastern standard time on March 5,
1998 (the "Record Date") are entitled to notice of and to vote at the Annual
Meeting.  For each matter which comes before the Annual Meeting, each share held
is entitled to one vote.  On the Record Date there were 31,055,846 shares of
Common Stock outstanding and eligible to vote.  This Proxy Statement and the
proxy card are first being sent on or about April 7, 1998 to each stockholder
entitled to vote at the Annual Meeting.  Accompanying this Proxy Statement is
the Company's annual report to stockholders for the year ended December 31,
1997.

VOTING AND REVOCATION OF PROXIES

If the enclosed proxy card is executed and returned on or prior to the date of
the Annual Meeting and not revoked, all shares of Common Stock represented
thereby will be voted.  Each proxy will be voted as directed by the stockholder
or authorized representative.  IF NO SUCH DIRECTION IS SPECIFIED, SIGNED PROXY
CARDS WILL BE VOTED FOR PROPOSALS 1 AND 2 IN ACCORDANCE WITH THE RECOMMENDATION
OF THE BOARD OF DIRECTORS.

VOTING

All votes will be tabulated by the inspector of election appointed for the
Annual Meeting who will separately tabulate affirmative and negative votes,
abstentions and broker non-votes (i.e., shares held by a broker or nominee which
are represented at the Annual Meeting, but with respect to which such broker or
nominee is not empowered to vote on a particular proposal).  The holders of a
majority of the shares of Common Stock entitled to vote at the Annual Meeting,
present in person or by proxy constitute a quorum.  Under the Company's Bylaws
and Delaware law, shares represented by proxies that reflect abstentions or
broker non-votes will be counted as shares of Common Stock that are present and
entitled to vote for purposes of determining the presence of a quorum.  The
affirmative vote of a plurality of the votes cast (in person or by proxy) at the
Annual Meeting will be required for the election of directors.  Abstentions,
broker non-votes and withholding of authority to vote will have no affect on the
outcome of the election of directors.  The two director nominees receiving the
highest number of votes shall be elected.  With respect to all matters other
than the election of directors, the affirmative vote of a majority of the votes
cast (in person or by proxy) at the Annual Meeting, including votes cast as
abstentions, will be required.  Abstentions will have the effect of a vote
"against" such other matters.  Broker non-votes will not be included in the
determination of the number of votes cast and therefore will have the effect of
reducing the number of affirmative votes required to achieve the majority vote
with respect to such other matters.

REVOCATION

A stockholder giving a proxy may revoke it at any time before it is voted, by
delivery to the Secretary of the Company of a subsequently executed proxy or a
written notice of revocation or by voting in person at the Annual Meeting.
Attendance at the meeting will not, by itself, revoke a proxy.  Returning your
completed proxy will not prevent you from voting in person at the Annual
Meeting, provided, however, that if your shares of Common Stock are held of
record by a broker, bank or other nominee and you wish to vote at the Annual
Meeting, you must obtain from such broker, bank or other nominee, a proxy card
issued in your name.
<PAGE>
 
                                  PROPOSAL 1
                                        
                             ELECTION OF DIRECTORS
                                        
The Board of Directors consists of three classes.  Directors hold office for
staggered terms of three years and until their successors have been duly elected
and qualified.  One of the three classes will be elected each year at the Annual
Meeting of Stockholders to succeed the directors whose terms are ending.  The
directors in Class I and Class II are serving terms ending at the Annual Meeting
of Stockholders in 1999 and 2000, respectively.

Class III is currently comprised of two directors.  Two directors in Class III
are to be elected at the 1998 Annual Meeting.  Proxies cannot be voted for more
than two nominees.  The Class III directors so elected will hold office as
directors until the year 2001 Annual Meeting of Stockholders and until their
respective successors have been duly elected and qualified.

UNLESS OTHERWISE DIRECTED, ALL EXECUTED AND RETURNED PROXIES WILL BE VOTED FOR
THE NOMINEES LISTED BELOW.  If any one or more of the nominees is unable to
serve for any reason or withdraws from nomination, proxies will be voted for the
substitute nominee or nominees, if any, proposed by the Board of Directors.  The
Board of Directors has no knowledge as of the date of this Proxy Statement that
any nominee will or may be unable to serve or will or may withdraw from
nomination.  Each of the Class III nominees is currently serving as a director
of the Company.  Information is set forth below concerning the Class III
director nominees and the directors continuing to serve in Class I and Class II.


                 NOMINEES FOR CLASS III DIRECTOR TERMS ENDING
                AT THE YEAR 2001 ANNUAL MEETING OF STOCKHOLDERS


The affirmative vote of a plurality of the votes cast at the Annual Meeting is
required for the election of each nominee Class III director of the Company.
The following two nominees have been proposed by the Board of Directors for
election as Class III directors of the Company.

MARK R. RUTENBERG, age 46, invented the PAPNET(R) Testing System in 1987 and
founded the Company in 1988.  Mr. Rutenberg currently serves as non-executive
Vice-Chairman of the Board of Directors.  He served as the Company's President
and Chief Executive Officer from its inception through June 1997 and as Chairman
of the Board from inception until November 1997.  From 1980 to 1988, Mr.
Rutenberg was responsible for the management and marketing of several advanced
defense programs.  Mr. Rutenberg is an inventor named in patents in the areas of
reliable system design, image analysis and cancer cell detection.  Mr. Rutenberg
holds a B.A. from Oberlin College in neuropsychology, and received an M.S. in
Electrical Engineering from Cleveland State University.  Under the terms of Mr.
Rutenberg's Restated Employment Agreement, dated June 29, 1997, the Company
agreed to renominate Mr. Rutenberg for election to the Board of Directors at the
1998 Annual Meeting of Stockholders. Mr. Rutenberg and Mr. Genberg, another
member of the Board of Directors, are first cousins.

ELIZABETH COGAN FASCITELLI, age 39, has served as a director of the Company
since 1993.  Ms. Fascitelli has been employed by the investment banking firm of
Goldman, Sachs & Co. since 1984 and is a Managing Director in their Principal
Investment Area.


               THE BOARD OF DIRECTORS RECOMMENDS A VOTE IN FAVOR
          OF EACH NAMED NOMINEE SET FORTH ABOVE IN PROPOSAL NUMBER 1.
                                        

                                       2
<PAGE>
 
                    CLASS I DIRECTORS WHOSE TERMS END AT THE
                      1999 ANNUAL MEETING OF STOCKHOLDERS
                                        

CARL GENBERG, age 46, has served as a director of the Company since 1990.  Mr.
Genberg is currently President of Cytology West, Inc., which is the territorial
licensee of the PAPNET(R) technology for the states of Nevada, Arizona, Utah and
San Diego County, California.  Until June 1993, Mr. Genberg was General Counsel
of the Company. Messrs. Rutenberg and Genberg are first cousins.

ARTHUR L. HERBST, M.D., age 66, has served as a director of the Company since
June 1996.  Dr. Herbst has served since 1976 as Chairman of the OB-GYN
Department and Joseph Bolivar DeLee Distinguished Service Professor at the
University of Chicago.

UZI ISH-HURWITZ, age 54, has served as a director of the Company since June
1996.  Mr. Ish-Hurwitz joined the Company in April 1993 and has served in
several executive capacities, including as Co-Chief Executive Officer of the
Company from July 1997 until November 1997.  Mr. Ish-Hurwitz was the co-founder
of Indigo Graphic Systems, Ltd. (Rehovot, Israel), and served as its President
from 1987 to 1992.  From 1973 to 1986, Mr. Ish-Hurwitz served as Vice President-
Operations of Scitex Corporation, Ltd. (Israel). Mr. Ish-Hurwitz is a graduate
of the Technion-Israeli Institute of Technology with a B.Sc. in Electrical
Engineering and has completed fellowship programs at the London Business School
and the Harvard Business School Advanced Management Program.


                   CLASS II DIRECTORS WHOSE TERMS END AT THE
                   YEAR 2000 ANNUAL MEETING OF STOCKHOLDERS
                                        

C. RAYMOND LARKIN, JR., age 49, has served as a director of the Company since
February 1996 and as non-executive Chairman of the Board since November 1997.
Mr. Larkin served as President and Chief Executive Officer of Nellcor Puritan
Bennett, Inc., a medical device company which is a division of Mallinckrodt,
Inc., from November 1989 through March 1998.

PAUL R. SOHMER, M.D., age 49, has served as President, Chief Executive Officer
and a director of the Company since November 1997.  Prior to joining the
Company, from 1993 to 1996 he served as President of Genetrix, Inc., the largest
privately-owned U.S. genetics services company.  From 1996 until November 1997,
Dr. Sohmer provided consulting services to the investment community and
industry, and evaluated investment and strategic opportunities in early and mid-
stage technology and specialty care companies.  From 1991 through 1992, Dr.
Sohmer served as the Corporate Vice President of Professional Services and
President of the Professional Services Organization for the Nichols Institute, a
clinical laboratory company where he was responsible for marketing, sales,
information services and clinical studies.

STUART M. ESSIG, age 36, has served as a director of the Company since 1993.  In
December 1997 Mr. Essig became President and Chief Executive Officer of Integra
LifeSciences Corporation, a medical technology company focusing on tissue
regeneration.  Prior to his affiliation with Integra, in 1988 he joined the
investment banking firm of Goldman, Sachs & Co. where he served in various
capacities, including, from 1996 until December 1997, as a Managing Director in
their Investment Banking Division, Healthcare Department.


     FURTHER INFORMATION CONCERNING THE BOARD OF DIRECTORS AND COMMITTEES
                                        
The Board of Directors of the Company directs the management of the business and
affairs of the Company, as provided by Delaware law.  The Board of Directors has
two standing committees, the Audit Committee and the Compensation Committee.
From time to time, special committees may be established under the direction of
the Board of Directors when necessary to address specific issues.  From July
through November 1997 the non-employee members of the Board of Directors
coordinated the search and hiring of a new President and CEO of the Company.  In
March 1998 the Board of Directors established a Nominating Committee.

                                       3
<PAGE>
 
  MEETINGS OF THE BOARD OF DIRECTORS AND COMMITTEES OF THE BOARD OF DIRECTORS
                                        
The Board of Directors held six meetings during 1997.  Each incumbent director
participated in 75% or more of the aggregate number of 1997 meetings of the
Board of Directors and 1997 meetings of the respective committees on which each
such director served.

The Audit Committee's principal functions are to meet with the Company's
independent accountants to review the Company's internal controls and financial
management practice, review the annual audit of the Company by its independent
auditors, review the annual financial statements of the Company and the related
audit report of the Company as prepared by the independent auditors, recommend
the selection of independent auditors each year and review audit and any non-
audit fees paid to the Company's independent auditors.  The Audit Committee
reports its findings and recommendations to the Board of Directors for
appropriate action.  The Audit Committee held three meetings in 1997.  The 1997
Audit Committee was composed of two non-employee directors, Stuart M. Essig and
C. Raymond Larkin, Jr., each of whom is continuing to serve as a member of the
Audit Committee at the date of this Proxy Statement.

The Compensation Committee recommends to the Board of Directors compensation for
the Company's employees.  The Compensation Committee held two meetings in 1997.
The 1997 Compensation Committee was composed of three non-employee directors,
Elizabeth Cogan Fascitelli, Carl Genberg and Arthur L. Herbst, M.D., all of whom
are continuing to serve as members of the Compensation Committee at the date of
this Proxy Statement.  Discussion of the Compensation Committee's
recommendations may be found below under the caption "Report on 1997 Executive
Compensation."

The non-employee members of the Board of Directors as a group coordinated the
search for a new President and CEO of the Company and presented material issues,
developments and recommendations to the entire Board of Directors for
deliberation.  Such non-employee members of the Board were C. Raymond Larkin,
Jr., Elizabeth Cogan Fascitelli, Stuart M. Essig, Carl Genberg and Arthur L.
Herbst, M.D.  A separate committee was not established by the Board of Directors
for the search and hiring of a new President and CEO of the Company.

          COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
                                        
Decisions with respect to compensation for the 1997 fiscal year were made by the
entire Board of Directors on the recommendation of the Compensation Committee.
Members of the Compensation Committee are outside directors who are not officers
or employees of the Company or its subsidiaries and are not eligible to
participate in any of the plans or programs that such committee administers.

The Company has entered into consulting agreements with various individuals
prominent in the field of cytology, pathology and gynecologic oncology,
including Dr. Arthur L. Herbst, a director who serves on the Compensation
Committee.  Dr. Herbst's consulting agreement provides the Company with
additional intellectual resources in the areas of product development,
commercialization and clinical studies of the PAPNET(R) Testing System.  Dr.
Herbst's consulting agreement provided for an annual base fee of $20,000 plus
expenses and additional fees for special projects.  The agreement with Dr.
Herbst expired at the end of 1997.  The Company is currently negotiating a new
agreement with Dr. Herbst which is expected to be substantially the same as the
prior agreement and to have a term ending on December 31, 1999.  The Company
paid Dr. Herbst approximately $32,000, $36,000 and $28,000 in 1997, 1996 and
1995, respectively, plus reimbursement of expenses incurred in connection with
such services.  The Company believes that the terms of Dr. Herbst's consulting
agreement are no less favorable than the terms it has received for similar
agreements entered into with parties unaffiliated with the Company.

Carl Genberg, a director of the Company, has served as a technical consultant to
the Company with respect to matters relating to product development and analysis
of competitor products.  During 1997 Mr. Genberg was paid $62,000 by the Company
for his services in such capacity, plus reimbursement of expenses incurred in
connection with such services.  The Company believes that the terms of Mr.
Genberg's consulting arrangement are no less favorable than the terms it has
received for similar arrangements entered into with consultants unaffiliated
with the Company.

From 1989 through 1991, the Company sold various long-term territorial license
agreements (the "License Agreements") for the PAPNET(R)  Testing System.
Following mergers of the various entities holding the License 

                                       4
<PAGE>
 
Agreements, there are currently two licensees. Carl Genberg, a director of the
Company and member of the Compensation Committee, has significant ownership
interests in the two licensees and is an officer and director of Cytology West,
Inc., holder of the License Agreement relating to Arizona, Nevada, Utah and San
Diego County. The holders of the License Agreements receive royalties on an
annual basis which the Company estimates will be approximately 10% of its United
States revenues over the term of the License Agreements, however, the actual
expense of such royalties may differ from the estimated percentage depending on
variation in geographical origin of Company revenues. In 1997, the Company's
royalty obligation was equal to approximately 18.9% of the Company's United
States revenues, because a disproportionate share of revenues came from certain
licensed territories. The Company's aggregate royalty expense incurred under the
License Agreements was approximately $988,000, $286,000 and $87,000 in 1997,
1996 and 1995, respectively. In accordance with a settlement agreement entered
into in 1995 which clarified previously disputed elements of the License
Agreements, the Company is renegotiating revised licenses (the "Restated
Licenses") with the two licensees pursuant to which the rights and obligations
will be clarified but as to which the economic terms will not be materially
altered except that slides received by the Company from multistate national
laboratories will be deemed to have been received from the licensed territories
pro rata with respect to each territory's population as a percentage of the
entire United States population. The Restated Licenses will expire on December
31, 2025. The Company believes that the terms of the foregoing transactions
involving Mr. Genberg are no less favorable than the terms it has received for
similar transactions entered into with persons unaffiliated with the Company.

The Board of Directors are of the opinion that the consulting arrangements with
Dr. Herbst and Mr. Genberg do not affect their respective objectivity or
performance as members of the Compensation Committee.  In the opinion of the
Board of Directors, all of the directors serving on the Compensation Committee
are independent of Management and free of any relationship that would interfere
with their exercise of independent judgment.

                           COMPENSATION OF DIRECTORS
                                        
The Company's 1993 Stock Incentive Plan, as amended and restated October 25,
1995 (the "Incentive Plan") provides for the non-discretionary grant of options
to each of the Company's non-employee directors ("Director Options") of (i)
2,500 shares of Common Stock to each non-employee director who becomes a member
of the Board of Directors after October 25, 1995 upon election or appointment
and (ii) an additional 2,500 shares of Common Stock annually on the first
business day following the annual meeting of the stockholders to non-employee
directors continuing to serve at such date.  The exercise price of such options
granted under the Incentive Plan is set at the closing price of publicly traded
Common Stock on the day immediately preceding the grant date.  The options
granted under the Incentive Plan vest six months and one day following the date
of grant.

The members of the Board of Directors receive reimbursement of their expenses
incurred in connection with attendance at Board of Directors and committee
meetings.

The Company's compensation to non-employee directors consists of an annual
retainer of $6,000, a fee of $1,000 for each meeting attended on location ($500
for telephonic meetings), $500 for Board of Directors' committee meetings held
on the same day as a Board meeting, and $1,000 for committee meetings ($500 for
telephonic committee meetings) which are held on separate days from Board
meetings.

In December 1997, non-employee members of the Board of Directors were each
granted a one-time fee of $10,000 as compensation for time spent on matters
related to the search and hiring of a new President and CEO of the Company.  In
lieu of such cash fee, each such Committee member was provided with an
alternative to accept restricted Common Stock in an amount equivalent to the
cash fee as determined by the closing quote on NASDAQ on the business day
immediately prior to the grant date, which was $3.156 per share.  Mr. Genberg
declined acceptance of his fee.  Mr. Larkin and Dr. Herbst each accepted 3,168
shares of restricted Common Stock in lieu of the cash fee.  Ms. Cogan Fascitelli
and Mr. Essig accepted the cash fee notwithstanding their preference for
restricted Common Stock because upon advice of counsel, given  their particular
circumstances, such acceptance would potentially constitute a violation of the
rules and regulations of Section 16 of the Securities Exchange Act of 1934, as
amended (the "Exchange Act").

                                       5
<PAGE>
 
                         SECURITY OWNERSHIP OF CERTAIN
                        BENEFICIAL OWNERS AND MANAGEMENT
                                        
The following table sets forth, as of the close of business on March 14, 1998
(unless otherwise noted), information regarding the beneficial ownership of the
Company's Common Stock by (i) directors, (ii) the individuals serving as Chief
and Co-Chief Executive Officer during the year ended December 31, 1997, (iii)
three of the Company's most highly compensated executive officers and two former
executive officers serving at the year ended December 31, 1997 (referred to
hereafter together with the individuals serving during 1997 in the capacity of
Chief and Co-Chief Executive Officers, as the "Named Executive Officers"), (iv)
all directors and executive officers of the Company as a group and (v) each
person or entity known by the Company to beneficially own 5% or more of the
outstanding shares of Common Stock.


<TABLE>
<CAPTION>
                                                                                  Amount Beneficially           
Title of Class                     Name and Address of Beneficial Owner                 Owned (1)              Percent of Class
- --------------                     ------------------------------------                 -------                ----------------   
<S>                        <C>                                          <C>                            <C>
Common Stock                     The Goldman Sachs Group, L.P.                              8,337,395                  26.8%
                                   and related investors (2)
                                   85 Broad Street, New York, NY 10004
Common Stock                     H and S Trust and related investors (3)                    3,751,676                  12.0%
                                   Suite 3C, Centre Plaza
                                   Horseback Lane
                                   Gibraltar
Common Stock                     Edelson Technology                                         1,871,465                   5.9%
                                   Partners II, L.P. (4)
                                   Whiteweld Centre
                                   Woodcliff Lake, NJ 07675
Common Stock                     Paul R. Sohmer, M.D. (5)                                     140,000                     *
Common Stock                     Mark R. Rutenberg (6)                                      1,358,804                   4.3%
Common Stock                     Elizabeth Cogan Fascitelli (7)                                 7,500                     *
Common Stock                     Stuart M. Essig (8)                                           10,000                     *
Common Stock                     Carl Genberg (9)                                              23,351                     *
Common Stock                     Arthur L. Herbst, M.D. (10)                                   18,768                     *
Common Stock                     C. Raymond Larkin, Jr. (11)                                   13,168                     *
Common Stock                     Uzi Ish-Hurwitz  (12)                                        109,299                     *
Common Stock                     David Duncan, Jr. (13)                                        57,268                     *
Common Stock                     Zeev Hadass (14)                                              66,000                     *
Common Stock                     John B. Henneman, III (15)                                    97,014                     *
Common Stock                     James M. Herriman (16)                                       206,769                     *
Common Stock                     Laurie J. Mango, M.D. (17)                                   206,769                     *
Common Stock                     Andrew C. Panagy (18)                                         83,468                     *
Common Stock                     All directors and executive officers as a
                                   group (14 persons, including the
                                   individuals listed above) (19)                           2,496,854                   7.8%
 
</TABLE>
*    Less than 1% beneficial ownership.

(1)  This table is based upon information supplied by directors, current and
     former executive officers, and Schedules 13D and 13G, if any, filed with
     the Securities and Exchange Commission (the "SEC"). The words 

                                       6
<PAGE>
 
     "group" and "beneficial" are as defined in regulations issued by the SEC.
     Beneficial ownership under such definition means possession of sole or
     shared voting power, or sole or shared investment and dispositive power,
     and includes shares which the individuals shown have the right to acquire
     on March 14, 1998 or within 60 days thereafter. Except as otherwise
     indicated in the footnotes to this table, the persons named have sole
     voting, investment and dispositive power with respect to all shares of
     Common Stock shown as beneficially owned by them.

(2)  Based on information provided to the Company dated February 27, 1998.
     Includes shares of Common Stock beneficially owned by certain investment
     limited partnerships of which affiliates of the Goldman Sachs Group, L.P.
     ("GS Group") are the general partners or the managing general partners.  GS
     Group owns 125,000 shares of Common Stock.  Also includes 1,481,500 shares
     of Common Stock held in managed accounts (the "Managed Accounts") for which
     Goldman, Sachs & Co. exercises voting or investment authority, or both, and
     1,196 shares of Common Stock acquired in the ordinary course of business by
     Goldman, Sachs & Co.  Also includes options exercisable for 15,000 shares
     of Common Stock in respect of Ms. Fascitelli's and Mr. Essig's service on
     the Board of Directors which are beneficially owned by GS Group.  GS
     Capital Partners, L.P. ("GSCP") beneficially owns 5,371,758 shares of
     Common Stock; Stone Street Fund 1993, L.P. ("Stone Street") beneficially
     owns 634,673 shares of Common Stock; and Bridge Street Fund 1993, L.P.
     ("Bridge Street," and together with Stone Street and GSCP, the "Limited
     Partnerships") beneficially owns 708,268 shares of Common Stock.  GS Group
     disclaims beneficial ownership of shares of Common Stock held (i) by the
     Limited Partnerships to the extent partnership interests in such
     partnerships are held by persons other than GS Group and its affiliates and
     (ii) in the Managed Accounts.  GS Group shares voting and dispositive power
     with respect to all shares reported as beneficially owned, other than the
     125,000 shares and the 15,000 options beneficially owned by GS Group.

(3)  Based on Schedule 13G/A filed with the SEC on February 13, 1997 with
     respect to H and S Trust's beneficial ownership of an aggregate of
     3,751,676 shares of the Company's Common Stock held of record by three
     Netherlands Antilles corporations: Leadville A.V.V., Tehila Holdings A.V.V.
     and Marineland A.V.V.  H and S Trust is the sole stockholder of such
     corporations.  Included in such shares beneficially owned by H and S Trust,
     Leadville A.V.V. is the holder of record of 1,815,642 shares of Common
     Stock which represents approximately 5.9% of the Company's outstanding
     shares.  H and S Trust has sole voting and sole dispositive power with
     respect to all shares which it beneficially owns.

(4)  Based on information provided to the Company dated as of March 1, 1998.
     Includes 216,650 shares of Common Stock held of record by Edelson
     Technology Partners III, L.P., a limited partnership under common control
     with Edelson Technology Partners II, L.P.

(5)  Includes 70,000 shares of Common Stock held of record in a self-directed
     Investment Retirement Account.

(6)  Includes an option exercisable for 500,000 shares of Common Stock.  Such
     amount does not include the performance-based option which becomes
     exercisable only under certain circumstances for 813,273 shares of Common
     Stock (described below in footnote (11) to the "Summary Compensation
     Table").

(7)  Includes options exercisable for 7,500 shares of Common Stock granted in
     respect of Ms.  Fascitelli's service on the Board of Directors.  Ms.
     Fascitelli is an officer of Goldman, Sachs & Co.  Share data shown excludes
     other shares and options for Common Stock shown as held by the Goldman
     Sachs Group, L.P. and related investors set forth above in footnote (2).
     Ms. Fascitelli has an understanding with the Goldman Sachs Group, L.P.,
     pursuant to which she holds such stock options for the benefit of the GS
     Group.  Ms. Fascitelli does not have any pecuniary interest in the stock
     options and therefore disclaims beneficial ownership.

(8)  Includes options exercisable for 7,500 shares of Common Stock granted in
     respect of Mr. Essig's service on the Board of Directors.  Mr. Essig is a
     former officer of Goldman, Sachs & Co.  Mr. Essig has an understanding with
     the Goldman Sachs Group, L.P., pursuant to which he holds such stock
     options for the benefit of the GS Group.  Mr. Essig does not have any
     pecuniary interest in the stock options and therefore disclaims beneficial
     ownership.

(9)  Includes options exercisable for 7,500 shares of Common Stock granted in
     respect of Mr. Genberg's service on the Board of Directors.

                                       7
<PAGE>
 
(10) Includes 800 shares of Common Stock held by Dr. Herbst's wife as to which
     shares Dr. Herbst disclaims beneficial ownership.  Includes options
     exercisable for 7,500 shares of Common Stock granted in respect of Dr.
     Herbst's service on the Board of Directors.

(11) Includes options exercisable for 7,500 shares of Common Stock granted in
     respect of Mr. Larkin's service on the Board of Directors.

(12) Includes options exercisable for 102,870 shares of Common Stock.

(13) Includes options exercisable for 50,000 shares of Common Stock.

(14) Includes options exercisable for 66,000 shares of Common Stock.

(15) Includes 750 shares of Common Stock owned in the aggregate by the spouse
     and children of Mr. Henneman, as to which shares Mr. Henneman disclaims
     beneficial ownership.  Includes options exercisable for 82,000 shares of
     Common Stock.

(16) Includes options exercisable for 89,000 shares of Common Stock.  Includes
     6,214 shares of Common Stock and options exercisable for 106,250 shares of
     Common Stock owned by the spouse of Mr. Herriman, as to which shares Mr.
     Herriman disclaims beneficial ownership.  Mr. Herriman is married to Dr.
     Mango, an officer of the Company.

(17) Includes options exercisable for 106,250 shares of Common Stock.  Includes
     5,305 shares of Common Stock and options exercisable for 89,000 shares of
     Common Stock owned by the spouse of Dr. Mango, as to which shares Dr. Mango
     disclaims beneficial ownership.  Dr. Mango is married to James M. Herriman,
     a former officer of the Company.

(18) Includes options exercisable for 80,000 shares of Common Stock.

(19) The shares of Common Stock shown with respect to directors and named
     executive officers include options exercisable within 60 days for an
     aggregate of 1,123,620 shares of Common Stock at exercise prices ranging
     from $4.00 to $22.63 per share, all of which shares of Common Stock were
     deemed outstanding for purposes of computing the percentage of shares of
     Common Stock outstanding and beneficially owned.  Directors and named
     executive officers also hold options that are not presently exercisable
     with respect to an additional 2,272,937 shares of Common Stock which, in
     accordance with the rules of the SEC, are not included in the table.

               (Proxy Statement Continues on the Following Page)

                                       8
<PAGE>
 
                             EXECUTIVE COMPENSATION
                           SUMMARY COMPENSATION TABLE

The Summary Compensation Table provides certain compensation information for the
Named Executive Officers for services rendered in all capacities during the
years ended December 31, 1997, 1996 and 1995.  The table includes the dollar
value of base salary, bonuses earned, option awards (shown in number of shares
of Common Stock) and certain other compensation, whether paid or deferred.
Bonus amounts shown as awarded with respect to 1997 and 1996 compensation were
granted in February 1998 and 1997, respectively.

<TABLE>
<CAPTION>
                                                                                        Long-Term
                                                     Annual Compensation           Compensation Awards
                                                  ---------------------------------------------------------
                                                                   Other                  Securities
                                                                  Annual                  Underlying          All other
                                                                  Compen-    Restricted Options/SARs          Compen-
Name and Principal Position         Year   Salary    Bonus        sation                      (#)             sation (1)
- -----------------------------------------------------------------------------------------------------------------------------
<S>                                 <C>   <C>       <C>      <C>  <C>        <C>         <C>            <C>   <C>         <C>
Paul R. Sohmer, M.D. (2)..........  1997  $ 55,865        -             -             -     1,000,000    (3)          -
 President and CEO
David Duncan, Jr..................  1997   144,700        -             -             -        20,000    (4)    $48,648   (12)
 Former Officer                                                         -             -        16,000    (5)          -
                                    1996   125,000   25,000             -             -             -                 -
                                    1995   125,000   45,750  (6)        -             -             -                 -
Zeev Hadass.......................  1997   144,700        -             -             -        20,000    (4)          -
 Vice President Product                                                 -             -        16,000    (5)          -
 Development and Lab                1996   125,000   25,000             -             -             -                 -
 Support                            1995   125,000        -             -             -        50,000    (7)          -
John B. Henneman, III (8).........  1997   144,700   22,650             -             -        20,000    (4)          -
 Executive Vice President of                                            -             -        16,000    (5)          -
    US Operations, Secretary        1996   125,000   25,000             -             -             -                 -
     and Chief Legal Officer        1995   125,000   57,600  (6)        -             -        25,000    (9)          -
 
James M. Herriman.................  1997   144,700        -             -             -        20,000    (4)          -
 Former Officer                                                         -             -        16,000    (5)          -
                                    1996   125,000   25,000             -             -             -                 -
                                    1995   125,000   68,400  (6)        -             -             -                 -
Uzi Ish-Hurwitz (8)...............  1997   168,706   22,650             -             -        35,000    (4)          -
 Executive Vice President   of                                          -             -        28,000    (5)          -
  Technical Operations              1996   150,000   25,000             -             -             -                 -
 and Chief Technical Officer,       1995   150,000   90,000  (6)        -             -             -                 -
 President, NSI Israel Ltd.
Laurie J. Mango, M.D..............  1997   144,700        -             -             -        20,000    (4)          -
 Vice President and   Chief                                             -             -        16,000    (5)          -
  Medical Officer                   1996   125,000   25,000             -             -             -                 -
                                    1995   125,000   80,000  (6)        -             -             -                 -
 
Andrew C. Panagy..................  1997   144,700        -             -             -        20,000    (4)          -
 Vice President, Marketing                                              -             -        16,000    (5)          -
 and Sales                          1996   125,000   25,000             -             -             -                 -
                                    1995   125,000   45,750  (6)        -             -             -                 -
Mark R. Rutenberg (10)............  1997   197,067        -             -             -        70,000    (4)          -
 Non-Executive Vice                                                     -             -        56,000    (5)          -
 Chairman of the Board              1996   175,000   25,000             -             -             -                 -
                                    1995   175,000  131,000             -             -       813,273   (11)          -
</TABLE>
(1)  Excludes certain perquisites which do not exceed the lesser of $50,000 or
     10% of the Named Executive 

                                       9
<PAGE>
 
     Officer's aggregate salary and bonus.

(2)  Dr. Sohmer was appointed President and CEO of the Company on November 4,
     1997.  Prior to such date he was not affiliated with the Company and
     therefore information with respect to 1996 and 1995 compensation are not
     applicable.

(3)  Dr. Sohmer received two option grants in connection with his appointment as
     President and CEO of the Company, all of which options were granted outside
     of the Incentive Plan.  The first such option is exercisable for 750,000
     shares of Common Stock at an exercise price of $4.56 per share, and the
     second option is exercisable for 250,000 shares of Common Stock at an
     exercise price of $10.00 per share, with each such option vesting at a rate
     of 25% per year commencing on the first anniversary of the date of grant
     and having a ten year term.

(4)  Such options were issued on February 13, 1997 at an exercise price of
     $10.125 per share, vesting 20% per year commencing on the first anniversary
     of the date of grant.  Under a replacement option plan offered by the Board
     of Directors and accepted by the Named Executive Officers, effective July
     28, 1997, all of such options were canceled prior to vesting.  See footnote
     (5) below and further information set forth below under the captions,
     "Option Grants In 1997 Fiscal Year" and "Ten Year Option Repricings."

(5)  Options issued pursuant to a replacement option plan offered by the Board
     of Directors and accepted by the Named Executive Officers, effective July
     28, 1997.  Such amount equals 80% of the respective options granted to such
     individual since October 1, 1996 and subsequently canceled under the
     foregoing replacement option plan.  Such options have an exercise price of
     $4.00 per share and a vesting period of 25% per year commencing at the
     first anniversary of the date of such replacement grant.  Such options are
     subject to 25% early vesting if the Named Executive Officer is terminated
     without cause by the Company on or prior to June 30, 1998.  See footnote
     (4) above and further information set forth below under the captions,
     "Option Grants In 1997 Fiscal Year" and "Ten Year Option Repricings."

(6)  One-half of the bonus amounts shown were paid, at the election of the named
     individual, in the form of shares of Common Stock at a fair market price of
     $7.00 per share, which in the aggregate amounted to 17,136 shares issued by
     the Company.

(7)  Option grant vests 20% at each anniversary of the date of grant and becomes
     fully vested in the year 2000; each option is exercisable at $7.00 per
     share of Common Stock.

(8)  Messrs. Henneman and Ish-Hurwitz served as Co-CEOs of the Company from June
     30, 1997 to November 3, 1997.

(9)  Option grant vests 20% at each anniversary of the date of grant and becomes
     fully vested in the year 2000; each option is exercisable at $6.00 per
     share of Common Stock.

(10) During 1997, Mr. Rutenberg served as President and CEO of the Company from
     January 1, 1997 through June 29, 1997, for which services he was
     compensated $97,067, plus a bonus granted in February 1997 with respect to
     his services to the Company during fiscal year 1996.  From June 30, 1997
     through December 31, 1997, Mr. Rutenberg remained a non-executive employee
     of the Company for which services he was compensated $100,000.

(11) The Company granted to Mr. Rutenberg a performance-based option under the
     Incentive Plan exercisable under certain conditions for 813,273 shares of
     Common Stock (the "Performance Based Option").  The following description
     of the Performance Based Option is qualified in its entirety by reference
     to the complete Incentive Plan, a copy of which has been filed with the SEC
     as an exhibit among the Company's required filings pursuant to federal
     securities laws.  The Performance Based Option may be exercised at a price
     equal to the Company's initial public offering price of the Common Stock
     ($15.00 per share) and covers 813,273 shares of Common Stock which is
     designed to produce an option value of $12.5 million if at any time during
     the option's ten-year term either of the following events occurs (the
     "Performance Goal"): (i) the  Company's share price over any 90 consecutive
     day period reaches $30.37 (the "Target Price") or (ii) all or substantially
     all of the Company's shares of Common Stock are acquired (an "Acquisition")
     at or above the Target Price.  If the Performance Goal is attained, the
     option will become exercisable as to one-third of the number of shares of
     Common Stock subject thereto on the later of (i) December 7, 1998 or (ii)
     the date that the Performance Goal is attained (the "Initial Vesting
     Date"), and will 

                                       10
<PAGE>
 
     become exercisable as to an additional one-third of the shares of Common
     Stock subject thereto on each of the first two anniversaries of the Initial
     Vesting Date; provided, however, that, if Mr. Rutenberg's employment is
     terminated by the Company without cause following an Acquisition that
     occurs following or simultaneously with the attainment of the Performance
     Goal, the option will be fully exercisable. No additional vesting will
     occur following Mr. Rutenberg's termination of employment or the expiration
     of the option's ten-year term. Under the terms of Mr. Rutenberg's Restated
     Employment Agreement (discussed in further detail below under the caption
     "Employment Agreements"), following Mr. Rutenberg's termination of
     employment with the Company for any reason other than for cause, to the
     extent vested and exercisable at the time of such termination the option
     may be exercised for a period of eight and one-half years after such date.
     The option provides for equitable adjustments to the Performance Goal, the
     number of shares of Common Stock subject to the option and the exercise
     price in the event of a corporate change in capitalization. The
     exercisability of the option will not accelerate upon the occurrence of a
     corporate change in control, and the option will terminate in connection
     with an Acquisition if the Performance Goal is not attained prior to or in
     connection with the Acquisition.

(12) Reimbursement of relocation expenses.


                       OPTION GRANTS IN 1997 FISCAL YEAR

The following tables show for the year ended December 31, 1997 certain
information regarding options granted to, exercised by, and held at year end by
the Named Executive Officers.  On February 13, 1997, the Board of Directors
granted an aggregate of 225,000 stock options to the Named Executive Officers
(the "February Options").  Under a replacement option plan (the "Replacement
Plan") offered by the Board of Directors and accepted by the Named Executive
Officers, effective July 28, 1997, all options granted since October 1, 1996
(including the February Options) were canceled prior to vesting and 180,000
replacement options were issued, vesting at a rate of 25% at each anniversary of
the date of grant and having a term of ten years, with each such grant amount
equivalent to 80% of their respective options canceled (the "Replacement
Options").  In addition, Dr. Sohmer was granted an aggregate of 1,000,000
options in connection with his appointment as President and CEO of the Company
on November 4, 1997.  The foregoing transactions resulted in a net grant of
1,180,000 stock options to the Named Executive Officers during the fiscal year
ended December 31, 1997.  See further discussion below under the caption "Report
on 1997 Executive Compensation."

<TABLE>
<CAPTION>
                                                                                             Potential Realizable Value at Assumed
                                                                                           Annual Rates of Stock Price Appreciation
                                                Individual Grants                                     for Option Term (1)
                                  -------------------------------------------------------  -----------------------------------------
<S>                                  <C>         <C>  <C>          <C>        <C>         <C>                  <C>
                                                      % of Total
                                     Number of         Options                                               
                                     Securities       Granted to   Exercise
                                     Underlying       Employees    or Base
                                      Options         in Fiscal     Price     Expiration
Name                                  Granted            Year       ($/sh)       Date           5%                 10%
- -----                                 -------            ----       ------       ----           ---                ----
<S>                                    <C>                 <C>      <C>         <C>          <C>              <C> 
Paul R. Sohmer, M.D................     750,000             26.2%    $ 4.56      11/4/07     $2,152,235        $5,454,185
                                        250,000              8.7%     10.00      11/4/07              0           458,812
David Duncan, Jr...................      20,000  (2)         0.7%     10.13      2/13/07        127,351           322,733
                                         16,000              0.6%      4.00      7/28/07         40,249           102,000
Zeev Hadass........................      20,000  (2)         0.7%     10.13      2/13/07        127,351           322,733
                                         16,000              0.6%      4.00      7/28/07         40,249           102,000
John B. Henneman, III..............      20,000  (2)         0.7%     10.13      2/13/07        127,351           322,733
                                         16,000              0.6%      4.00      7/28/07         40,249           102,000
James M. Herriman..................      20,000  (2)         0.7%     10.13      2/13/07        127,351           322,733
                                         16,000              0.6%      4.00      7/28/07         40,249           102,000
Uzi  Ish-Hurwitz...................      35,000  (2)         1.2%     10.13      2/13/07        222,865           564,782
                                         28,000              1.0%      4.00      7/28/07         70,436           178,499
Laurie J. Mango, M.D...............      20,000  (2)         0.7%     10.13      2/13/07        127,351           322,733
</TABLE>  

                                       11
<PAGE>
 
<TABLE> 
<S>                                     <C>                 <C>      <C>       <C>             <C>               <C> 
                                         16,000              0.6%      4.00      7/28/07         40,249           102,000
Andrew Panagy......................      20,000  (2)         0.7%     10.13      2/13/07        127,351           322,733
                                         16,000              0.6%      4.00      7/28/07         40,249           102,000
Mark R. Rutenberg..................      70,000  (2)         2.5%     10.13      2/13/07        445,729         1,129,565
                                         56,000              2.0%      4.00      7/28/07        140,872           356,998
</TABLE>

(1)  The potential realizable value is based on the term of the option at the
     time of its grant, which is ten years for the stock options granted to the
     Named Executive Officers in the table. The assumed 5% and 10% annual rates
     of appreciation over the term of the options are set forth in accordance
     with rules and regulations adopted by the SEC and do not represent the
     Company's estimates of stock price appreciation. The potential realizable
     value is calculated by assuming that the stock price on the date of grant
     appreciates at the indicated rate, compounded annually, for the entire term
     of the option and that the option is exercised and the stock is sold on the
     last day of its term at this appreciated stock price. No valuation method
     can accurately predict future stock prices or option values because there
     are too many unknown factors. No gain to the optionee is possible unless
     the stock price increases over the option term. Such a gain in stock price
     would benefit all stockholders.

(2)  All of such options were canceled on July 28, 1997 prior to vesting
     pursuant to acceptance by the Named Executive Officers of the Replacement
     Plan, as discussed in further detail below under the caption, "Report On
     1997 Executive Compensation." Notwithstanding the fact that all such stock
     options have been canceled, and that the recipients of such grants have no
     present or future beneficial ownership interest in such options, for
     purposes of compliance with the Exchange Act all option grants and related
     information must be disclosed.


                           TEN-YEAR OPTION REPRICINGS
                                        
The following table provides information on the 1997 Replacement Plan by the
Board of Directors with respect to certain stock options held by the Named
Executive Officers.  Under the Replacement Plan effective July 28, 1997, the
Board of Directors offered, and the Named Executive Officers serving at such
date accepted, a plan pursuant to which all options granted since October 1,
1996 were canceled and Replacement Options were issued, with each respective
replacement grant equal to 80% of the number of options canceled, vesting at a
rate of 25% per year and having a term of ten years.  The Replacement Plan is
discussed in further detail below under the caption, "Report on 1997 Executive
Compensation."

<TABLE>
<CAPTION>
                                                                                                                    
                                                                                                                    
                                           Number of        Number of       Market Price of   
                                            Options     Canceled Options   Stock At time of                         
             Name                Date      Canceled         Replaced          Replacement                           
- ----------------------------------------------------------------------------------------------                      
<S>                             <C>        <C>             <C>                <C>                              
David Duncan, Jr..............  7/28/97    20,000             16,000              $4.00                        
Former Officer                                                                                                 
Zeev Hadass...................  7/28/97    20,000             16,000               4.00                        
Vice President Product                                                                                         
 Development and Lab Support                                                                                   
John B. Henneman, III.........  7/28/97    20,000             16,000               4.00                        
Executive Vice President of                                                                                    
 US Operations, Secretary and                                                                                  
 Chief Legal Officer                                                                                           
James M. Herriman.............  7/28/97    20,000             16,000               4.00                        
Former Officer                 
<CAPTION> 

                                                                                           
                                      Exercise Price                     Length of Original 
                                       of Canceled                           Option Term    
                                      Options at Time   New Exercise     Remaining at Date  
                                      of Replacement        Price          of Replacement   
- --------------------------------------------------------------------------------------------
                                      <C>                 <C>                   <C>        
David Duncan, Jr..............          $10.13              $4.00         9 years 6 months 
Former Officer                                                                             
Zeev Hadass...................           10.13               4.00         9 years 6 months 
Vice President Product                                                                     
 Development and Lab Support                                                               
John B. Henneman, III.........           10.13               4.00         9 years 6 months 
Executive Vice President of                                                                
 US Operations, Secretary and                                                              
 Chief Legal Officer                                                                       
James M. Herriman.............           10.13               4.00         9 years 6 months  
Former Officer                 
</TABLE> 

                                       12
<PAGE>
 
<TABLE> 
<CAPTION> 
                                           Number of        Number of       Market Price of   
                                            Options     Canceled Options   Stock At time of    
Name                              Date      Canceled         Replaced          Replacement      
- ---------------------------------------------------------------------------------------------- 
<S>                             <C>         <C>               <C>                  <C> 
Uzi  Ish-Hurwitz..............  7/28/97     35,000             28,000               4.00         
Executive Vice President                                                                         
of Technical Operations                                                                          
and Chief Technical Officer,                                                                     
President, NSI Israel Ltd.                                                                       
Laurie J. Mango, M.D..........  7/28/97     20,000             16,000               4.00         
Vice President and Chief                                                                         
 Medical Officer                                                                                 
Andrew Panagy.................  7/28/97     20,000             16,000               4.00         
Vice President, Marketing and                                                                    
 Sales                                                                                           
Mark R. Rutenberg.............  7/28/97     70,000             56,000               4.00         
Non-Executive Vice            
Chairman of the Board          
<CAPTION>                                                            

                                       Exercise Price                     Length of Original
                                        of Canceled                           Option Term   
                                       Options at Time   New Exercise     Remaining at Date 
                                       of Replacement        Price          of Replacement  
 --------------------------------------------------------------------------------------------
<S>                                         <C>              <C>         <C> 
Uzi  Ish-Hurwitz..............              10.13             4.00        9 years 6 months        
Executive Vice President                                                                          
of Technical Operations                                                                           
and Chief Technical Officer,                                                                      
President, NSI Israel Ltd.                                                                        
Laurie J. Mango, M.D..........              10.13             4.00        9 years 6 months        
Vice President and Chief                                                                          
 Medical Officer                                                                                  
Andrew Panagy.................              10.13             4.00        9 years 6 months        
Vice President, Marketing and                                                                     
 Sales                                                                                            
Mark R. Rutenberg.............              10.13             4.00        9 years 6 months 
Non-Executive Vice            
Chairman of the Board         
</TABLE>

                                       13
<PAGE>
 
                AGGREGATED OPTION EXERCISES IN FISCAL YEAR 1997
                    AND FISCAL YEAR-END 1997 OPTION VALUES
                                       
The following table sets forth certain information regarding exercised options
and the number of shares of Common Stock covered by both exercisable and
unexercisable options on Common Stock held by the Named Executive Officers as of
December 31, 1997.  Each of these options was granted at exercise prices ranging
from $4.00 to $15.00 per share.  Each is a non-qualified option with a ten-year
term.  Pursuant to action of the Board and amendment of the relevant option
agreements, in connection with the appointment of a new President and CEO of the
Company, the vested portion of such options may be exercised for a period up to
two years after termination of employment without cause, so long as the optionee
remains employed with the Company until June 30, 1998.  In the case of Messrs.
Henneman and Ish-Hurwitz, such exercise period is extended for a period of up to
three years.  Of the unexercisable options granted to Mark R. Rutenberg, 813,273
are subject to the terms of the Performance Based Option whose vesting and
exercise period are described in footnote (11) of the Summary Compensation Table
above.

<TABLE>
<CAPTION>
 
                                                                           Number of Securities                 
                                                                     Underlying Unexercised Options at          
                                                                              Fiscal Year-End                   
                                                                   -----------------------------------          
                                      Shares            Value                                                   
                                   Acquired on          -----                                                   
Name                               Exercise (#)    Realized ($) (2)    Exercisable     Unexercisable            
- ----                               -------------   ----------------  ---------------  ----------------          
<S>                              <C>               <C>               <C>              <C>                       
Paul R. Sohmer, M.D............                 0               $0                 0         1,000,000          
David Duncan, Jr...............                 0                0            50,000            16,000          
Zeev Hadass....................                 0                0            66,000            46,000          
John B. Henneman, III..........                 0                0            77,000            31,000          
James M. Herriman..............                 0                0            89,000            16,000          
Uzi  Ish-Hurwitz...............                 0                0           102,870            28,000          
Laurie J. Mango, M.D...........                 0                0           106,250            16,000          
Andrew C. Panagy...............                 0                0            80,000            16,000          
Mark R. Rutenberg..............                 0                0           500,000           869,273          
</TABLE>

                                                         Value of Unexercised  
                                                             In-the-Money       
                                                              Options at        
                                                         Fiscal Year-End (1)    
                                                    ---------------------------
                                                   
                                            Exercisable     Unexercisable       
                                            -----------  --------------------   

Paul R. Sohmer, M.D............                      $0                   $0    
David Duncan, Jr...............                       0                    0    
Zeev Hadass....................                       0                    0    
John B. Henneman, III..........                       0                    0    
James M. Herriman..............                       0                    0    
Uzi  Ish-Hurwitz...............                       0                    0    
Laurie J. Mango, M.D...........                       0                    0    
Andrew C. Panagy...............                       0                    0    
Mark R. Rutenberg..............                       0                    0    
                                                                                
                                                                         
                                                                         
(1)  Values for "in-the-money" outstanding options represent the positive spread
     between the respective exercise prices of the outstanding options and the
     market value of the Common Stock as of December 31, 1997, which was $2.81.

(2)  Value realized is based on the market value of the Company's Common Stock
     on the date of exercise, minus the exercise price, and does not necessarily
     indicate that the optionee sold the stock resulting from such exercise.

                                       14
<PAGE>
 
                             EMPLOYMENT AGREEMENTS
                                        
During 1997, the Company entered into Employment Agreements with each of the
Named Executive Officers.

On July 1, 1997, the Company entered into three year restated employment
agreements with each Named Executive Officer serving as an officer of the
Company at such date: David Duncan, Jr., Zeev Hadass, John B. Henneman, III,
James Herriman, Uzi Ish-Hurwitz, Laurie J. Mango, M.D. and Andrew C. Panagy (the
"Executive Employment Agreements").  The material terms of each Executive
Employment Agreement are substantially similar with the exception of certain
terms for Mr. Ish-Hurwitz which are described below.  The respective Executive
Employment Agreement of each such Named Officer sets forth such individual's
executive position and duties.  Each Executive Employment Agreement provides for
a base salary of $151,000 per year, three weeks' vacation, and participation in
Company benefit plans, including eligibility for bonuses and stock option
grants.  Notwithstanding their contractual agreements with the Company, from
September 16, 1997 through November 1, 1997, each of the foregoing Named
Executive Officers adopted a voluntary reduction in salary of approximately 15%.
Each Executive Employment Agreement may be terminated with or without cause or
upon death or disability.  Upon termination of employment upon death or
disability, the Company shall pay the shorter of one year's salary from the date
of such event or the end of the term, and continue to provide, for such period,
to the disabled individual and/or his or her surviving dependents Company
benefits as then in effect.  In the event of termination for cause, the Company
shall have no further obligations with respect to base salary, and any
entitlement to benefits will be determined in accordance with Company policy as
then in effect.  In the event of termination without cause, for a period of one
year following such date, the Company shall continue to pay the base salary and
provide the benefits in effect prior to such termination.  Each Executive
Employment Agreement contains confidentiality and non-competition covenants
having a respective duration of five years and two years following termination.
Each Executive Employment Agreement provides for automatic  renewals for
additional one year periods following each term unless either party gives ninety
days prior notice.  The Executive Employment Agreement of Mr. Ish-Hurwitz varies
from the foregoing Executive Employment Agreements by having a base salary of
$174,000 per year and provision for certain other benefits customary for
executives serving similarly situated companies in Israel.

On November 4, 1997, the Company entered into a three year employment agreement
with Dr. Sohmer with respect to his services as President and CEO (the "CEO
Agreement").  The material terms of the CEO Agreement provide for a base salary
of $350,000 per year which may be increased upon review of individual and
Company performance, and eligibility for a bonus each year of up to 50% of such
base salary, provided, however, that for the 1998 fiscal year a guaranteed bonus
of $175,000 shall be paid by the Company.  The CEO Agreement provides for a
grant of options exercisable for an aggregate of 750,000 shares of Common Stock
at an exercise price of $4.56 per share, and a grant of options exercisable for
an additional 250,000 shares of Common Stock at an exercise price of $10.00 per
share, in each case vesting 25% each year, commencing on the first anniversary
of the date of grant.  The CEO Agreement provides for customary benefits offered
to all employees of the Company, three weeks' vacation and reimbursement of
relocation expenses.  The CEO Agreement may be terminated upon death or
disability, or by the Company with or without cause.  In the event of death or
disability, the Company shall continue to pay base salary and benefits for one
year following such date.  In the event of termination for cause, the Company
shall have no further obligations with respect to base salary but shall provide
benefits in accordance with Company policy as then in effect.  In the event of
termination without cause, the Company shall continue to pay the base salary and
benefits for a period of 18 months following the termination date.  The CEO
Agreement contains customary confidentiality provisions and a non-competition
covenant having a duration of two years following termination.  The CEO
Agreement provides for automatic renewals for additional one year periods
following each term unless either party gives ninety days prior notice.

In connection with the resignation of Mark Rutenberg as President and CEO of the
Company, the Company entered into a revised and restated employment agreement
with Mr. Rutenberg on June 29, 1997 (the "Revised Agreement") which will remain
in effect until November 19, 1998.  The material provisions of the Revised
Agreement provide for Mr. Rutenberg's continuation of employment with the
Company at an annual salary of $200,000 per year and participation in the
Company's executive benefit plans.  In addition, the Revised Agreement provides
for a non-recourse loan to Mr. Rutenberg in the amount of $600,000 which has
been secured by his pledge of 100,000 shares of Common Stock.  The loan is
repayable on the earlier of November 30, 1999 or the date which is ten days
after termination of his employment for any reason.  The Revised Agreement may
be terminated for cause or by either party upon thirty days written notice.  The
Revised Agreement provides that in the event of his voluntary termination prior
to November 19, 1998 or if terminated for cause, Mr. Rutenberg shall receive
$598,000.  If 

                                       15
<PAGE>
 
terminated for reasons other than cause, he shall receive $598,000 and the
equivalent of his remaining base salary as measured from such termination date
until the expiration date of the Revised Agreement. The options held by Mr.
Rutenberg to purchase Company stock have also been extended so as to expire
eight and one-half years after the expiration date of the Revised Agreement,
provided, however, that the Performance Based Option may be exercised for such
extended period only to the extent vested and exercisable at the expiration date
of the Revised Agreement. The Revised Agreement also contains confidentiality
and non-competition covenants for periods of five years and two years
respectively, and assignments to the Company of all rights to inventions,
discoveries, improvements and patentable and copyrightable works conceived by
him in the course of his employment with the Company that are related to the
business or activities of the Company.

The employment agreement governing Mr. Rutenberg's service during 1997 as
President and Chief Executive Officer of the Company (the "Former CEO
Agreement") commenced in November 1993 and terminated on June 29, 1997 upon the
effectiveness of the Revised Agreement described above.  The Former CEO
Agreement provided for an annual base salary, benefits, the use of a Company car
and eligibility for bonuses and stock option grants.  In the event terminated
other than for cause or disability or by Mr. Rutenberg for good reason, the
Former CEO Agreement provided for the Company to pay Mr. Rutenberg a one-time
severance payment equal to 2.99 times his annual base salary and continue
benefits for the shorter of one year or the balance of the term of his
employment agreement.  If employment were terminated for cause or by Mr.
Rutenberg without good reason, Mr. Rutenberg would have been entitled to receive
his salary through his date of termination.  If employment were terminated due
to death or disability, the Company would have continued base salary and
benefits for the shorter of one year following such event or the balance of the
term of agreement.  The Former CEO Agreement contained confidentiality and non-
competition covenants and also assignments to the Company of all rights to
inventions, discoveries, improvements and patentable and copyrightable works
conceived by him in the course of his employment with the Company that were
related to the business or activities of the Company.

CONSULTING AGREEMENTS

The Company has entered into consulting agreements with various individuals.
See the discussion set forth above under the caption, "Compensation Committee
Interlocks and Insider Participation" and the disclosures below under the
caption, "Certain Transactions."


               (Proxy Statement Continues on the Following Page)

                                       16
<PAGE>
 
                     REPORT ON 1997 EXECUTIVE COMPENSATION
                                        
The Company's executive compensation programs are designed to attract, retain
and motivate the executive talent required to achieve the Company's business
objectives and increase stockholder value.  The 1997 compensation programs for
the Company's executive officers (the "Management") were administered by the
entire Board of Directors, based upon the recommendations of the Compensation
Committee.

GENERAL

Under the Company's compensation policies relating to Management, total
compensation for each member of Management consists of a base salary and may
also include an annual cash bonus and long-term incentives.  The long-term
incentives may consist of stock options, stock appreciation rights, dividend
equivalent rights, restricted and unrestricted stock, performance units and
performance shares.  The annual bonus and long-term incentives introduce risk to
the total executive compensation package.  These elements are variable, may
fluctuate significantly from year to year and are directly tied to Company and
individual performance.

To ensure that Management's interest in the Company is aligned with those of its
stockholders, a portion of executive compensation is generally delivered through
equity.  Equity compensation is linked to the long-term performance of the
Company and is used to provide an incentive that focuses attention on managing
the Company from an owner's perspective.  Compensation tied to equity in the
Company provides a level of risk and upside opportunity that motivates
Management to achieve the Company's long-term goals and objectives.

The Compensation Committee annually reviews the competitiveness of the Company's
executive compensation programs and recommends changes, if any, to the Board of
Directors.

EXECUTIVE OFFICERS' COMPENSATION

The Board of Directors adopted a peer companies compensation program in 1997
following a study commissioned by the Board of Directors and undertaken by KPMG
Peat Marwick LLP ("KPMG").  The KPMG study provided compensation reference
points through analysis and comparison to a group of peer companies in the
medical device industry which have significant high-technology product
orientation and similar market capitalization-to-revenue ratios (collectively,
the "Peer Companies").  The Board of Directors relied on KPMG's findings to
determine that the compensation of Management should, as an aggregate of salary,
bonus awards and stock options, follow as a general guideline the median of the
Peer Companies' compensation range.  The cash bonuses which may be granted by
the Board of Directors under its Peer Companies compensation program are
intended to reward both corporate and individual performance with each such
component weighted 50% of the total cash bonus award, except in the case of the
Chief Executive Officer whose terms are described below under the caption "CEO
Compensation."  The Board of Directors has established targets for cash bonus
awards in amounts graduated by officer level that, when aggregated with such
officer's salary and target stock option grant, follow as a guideline the median
of the Peer Companies' aggregate compensation range for such grade level.  The
corporate performance portion of bonuses is based on objective criteria and the
individual performance portion is based on subjective criteria.  Minimum dollar
thresholds for corporate performance are set by the Board of Directors, 80%
percent of which must be attained prior to the grant of any corporate
performance portion of the bonus award.  The corporate performance portion of
the bonus awarded is pro-rated proportionate to the percentage of the threshold
target attained.  The portion of the cash bonus related to individual
performance is determined by considering the executive officer's position level,
the area of responsibility and by reviewing whether such person has performed in
an outstanding manner, above expectations, meeting expectations, or below
expectations.

No cash bonuses were granted by the Board of Directors to Named Executive
Officers with respect to 1997 Company performance.

The Board of Directors granted extraordinary service bonuses to John B.
Henneman, III, and Uzi Ish-Hurwitz, who, in addition to their respective 1997
appointed duties, served together as Co-Chief Executive Officers of the Company
from July 1997 until November 1997.  Each such extraordinary service bonus was
paid in the amount of $22,650 in January 1998.  No other cash bonuses were
granted by the Board of Directors to Named Executive Officers with respect to
1997 individual performance.

                                       17
<PAGE>
 
Under its Peer Companies compensation program, the Board of Directors has
determined that stock option grants to Management, when aggregated with each
executive officer's salary and maximum potential bonus award, should follow as a
guideline the median of the Peer Companies' aggregate compensation range.  The
targeted option grant levels assume an annual award of stock options with an
exercise price set at the publicly traded market value of the Company's Common
Stock on a fixed date.  All such options are for the purchase of Common Stock.
In granting stock option awards, the Board of Directors may also take into
account prior stock option grants in determining the number of stock options
that may be granted to each recipient.

In February 1997 the Board granted an aggregate of 225,000 stock options to the
Named Executive Officers at an exercise price of $10.13 per share, vesting over
a five year period and having a ten year term.  During the first six months of
1997, however, the market price of the Common Stock of the Company decreased
such that options held by key employees had exercise prices substantially above
the market price.  The Board of Directors concluded that in order for stock
options to continue to be sufficient incentive to the Company's key employees,
the replacement of these options with newly priced options was necessary.
Accordingly, effective July 28, 1997, the Board of Directors offered to each
Named Executive Officer serving the Company at that date, the opportunity to
exchange all stock options granted subsequent to October 1, 1996 (the "No-Value
Options") for Replacement Options in an amount equal to 80% of the respective
No-Value Options relinquished by such Named Executive Officer, with a new
exercise price of $4.00 per share and a vesting period of 25% per year
commencing at the first anniversary of the date of such replacement grant, with
a 25% accelerated vesting provision if the Named Executive Officer is terminated
without cause by the Company on or prior to June 30, 1998.  All such Named
Executive Officers holding No-Value Options accepted the exchange offer and an
aggregate of 225,000 No-Value Options were canceled upon issuance of 180,000
Replacement Options to the Named Executive Officers.  The new exercise price of
$4.00 per share was determined by the fair market value of the Company's Common
Stock as quoted on NASDAQ at the close of business on the day prior to the date
of grant.  The Replacement Options provide for the purchase of a fewer number of
shares of Common Stock, but have a shorter vesting period than the No-Value
Options which they replaced.  In determining to offer the Replacement Options to
the Company's Management, the Board of Directors considered many factors,
including, but not limited to, the fairness of such replacement in relation to
the Company's other stockholders.  The Board of Directors concluded that
replacement of a fewer number of shares would reduce stockholder dilution while
permitting the Company to more effectively retain and motivate its key
employees. The Board's rationale for shortening the vesting period of the
Replacement Options was to coordinate the time requirements for full vesting of
such options relative to the originally anticipated vesting schedule for the No-
Value Options.  Excluding Dr. Sohmer, whose option grants in November 1997 are
discussed in further detail below under the caption "CEO Compensation", the
Replacement Plan resulted in a net grant of 180,000 stock options to the Named
Executive Officers during the fiscal year ended December 31, 1997.

In addition, in recognition of the importance of maintaining continuity of
Management following the appointment of Dr. Sohmer as the new President and CEO,
the Board of Directors amended all employee stock option agreements held by each
of the Named Executive Officers, extending the exercise period for the vested
portion of such options, upon termination of employment with the Company, from a
period of ninety days to a period of three years from such termination date,
provided that the respective Named Executive Officer remain with the Company
until June 30, 1998.  The exercise extension period also becomes effective with
respect to such options if a Named Executive Officer is terminated without cause
prior to June 30, 1998.

CEO COMPENSATION

On November 4, 1997 the Board of Directors appointed Paul R. Sohmer, M.D. to the
position of President and Chief Executive Officer of the Company and elected him
to the Board of Directors.  In negotiating Dr. Sohmer's compensation package,
the Board of Directors took into account the arrangements of similarly situated
companies with executives of Dr. Sohmer's comparable expertise and experience,
as well as the Company's need to attract, maintain and provide incentives for a
highly qualified Chief Executive Officer capable of addressing the near-term and
long-term challenges facing the Company.  Dr. Sohmer's employment agreement
provides for a base salary of $350,000 per year that may be increased annually
at the discretion of the Compensation Committee.  In considering base salary
adjustments to Dr. Sohmer's compensation, the Board of Directors intends to
follow as a guideline amounts that, when aggregated with stock option grants and
maximum potential bonus award, are at the median of the Peer Companies'
aggregate compensation range.  The salary for Dr. Sohmer reported in the Summary
Compensation Table above reflects the salary actually paid to Dr. Sohmer in
1997.  As part of Dr. Sohmer's employment agreement, he will receive a
guaranteed bonus of $175,000 for the first year of his employment, and

                                       18
<PAGE>
 
thereafter be eligible for a 50% bonus above his annual base salary.  The Board
of Directors has determined that the criteria for granting future year cash
bonuses to Dr. Sohmer will be based entirely on corporate performance.  The
total cash compensation received by Dr. Sohmer in respect of his 1997 service as
President and Chief Executive Officer of the Company was $55,865.  Dr. Sohmer
received two option grants in connection with his appointment as President and
CEO of the Company.  The first such option is exercisable for 750,000 shares of
Common Stock at an exercise price of $4.56 per share, and the second option is
exercisable for 250,000 shares of Common Stock at an exercise price of $10.00
per share, with each such option vesting at a rate of 25% per year commencing on
the first anniversary of the date of grant.  Each such option has a term of ten
years.  The Board of Directors has determined that stock option grants to Dr.
Sohmer in fiscal year 1998 and future periods should follow as a guideline
amounts that, when aggregated with salary and maximum potential bonus award, are
at the median of the Peer Companies' aggregate compensation range.  The targeted
grant levels assume an annual award of stock options with an exercise price set
at  the publicly traded market value of the Company's Common Stock on a fixed
date.

Messrs. John B. Henneman, III and Uzi Ish-Hurwitz were appointed by the Board of
Directors in July 1997 to serve as Co-Chief Executive Officers of the Company
until the appointment of a new President and CEO of the Company.  During such
tenure, each of Messrs. Henneman and Ish-Hurwitz also continued to serve the
Company in their other respective officer capacities to which they were
appointed prior to their special appointments as Co-Chief Executive Officers.
The two officers were compensated according to the terms of their respective
Executive Employment Agreements entered into on July 1, 1997, governing, in the
case of Mr. Henneman, his services at such time as Co-CEO, Vice President of
Corporate Development, Secretary and General Counsel, and in the case of Mr.
Ish-Hurwitz, his services at such time as Co-CEO, Executive Vice President,
Chief of Technical Operations and President, Neuromedical Systems Israel, Ltd.
Under the terms of each such agreement, the per annum base salary is $151,000
for Mr. Henneman, and $174,000 for Mr. Ish-Hurwitz.  Notwithstanding their
contractual agreements with the Company, from September 16, 1997 through
November 1, 1997, each of Messrs. Henneman and Ish-Hurwitz adopted a voluntary
reduction in salary of approximately 15%.  In recognition of the importance of
maintaining continuity of Company management following the anticipated
appointment of a new President and CEO, in September 1997 the Board of Directors
entered into amendments of the employee stock option agreements held by Messrs.
Henneman and Ish-Hurwitz extending the exercise period for such options upon
termination of employment with the Company from a period of ninety days to a
period of three years from such termination date, provided that they remain with
the Company until June 30, 1998 or are terminated without cause prior to such
date. Upon the appointment in November 1997 of Dr. Sohmer as President and CEO,
Messrs. Henneman and Ish-Hurwitz resumed their full time services to the Company
in their other respective executive capacities.

Mr. Mark R. Rutenberg founded the Company and served as its President and CEO
from inception in 1988 until June 29, 1997 when he resigned from his executive
positions.  He served as Non-Executive Chairman of the Board of Directors until
November 1997 when he became Non-Executive Vice Chairman of the Board.  Pursuant
to the terms of his Revised Employment Agreement, Mr. Rutenberg currently
remains an employee of the Company.  Mr. Rutenberg's actual salary earned in his
capacity as President and CEO from January 1, 1997 through his resignation from
such positions on June 29, 1997 was $97,067.  Mr. Rutenberg received no cash
bonus in respect of 1997 individual or corporate performance.  The salary
reported in the Summary Compensation Table above sets forth the aggregate
amounts paid to Mr. Rutenberg for 1997 services to the Company in all
capacities.  Mr. Rutenberg received 70,000 stock options in February 1997 at an
exercise price of $10.13, vesting at a rate of 20% on each anniversary of the
date of grant and having a ten year term.  Such options were subsequently
canceled and replaced by 56,000 stock options on July 28, 1997 at an exercise
price of $4.00 per share, vesting at a rate of 25% on each anniversary of the
date of such grant and having a ten year term, pursuant to the Replacement Plan
adopted by the Board of Directors, as discussed in further detail above in this
Executive Compensation Report under the caption "Executive Officer
Compensation."

Messrs. Rutenberg and Ish-Hurwitz excused themselves from discussions and
determinations by the Board with respect to all issues concerning their
respective compensation, including salary, bonus, and stock option awards.

The foregoing Report on 1997 Executive Compensation is submitted by the members
of the 1997 Compensation Committee of the Board of Directors.

                                    Elizabeth Cogan Fascitelli
                                    Carl Genberg
                                    Arthur L. Herbst, M.D.

                                       19
<PAGE>
 
                               PERFORMANCE GRAPH
                                        
The graph and chart set forth below show the value of an investment of $100 from
the period beginning on December 7, 1995 (the date of the initial public
offering of the Company's Common Stock at a price of $15.00 per share) in each
of the Company's Common Stock ("NSIX"), the NASDAQ Stock Market Total Return
Index ("NASDAQ") and the Dow Jones Medical and Biotechnology Industry Group
Index (the "Group Index").  All values assume reinvestment of the pre-tax value
of dividends paid by companies included in each of these indexes and
calculations as of the dates set forth below.


                             [GRAPH APPEARS HERE]

                12/7/95    12/31/95  12/31/96  12/31/97
                -------    --------  --------  --------
NSIX            $100.00    $134.17    $88.34    $18.73
NASDAQ          $100.00     $99.90   $122.59   $151.40
GROUP INDEX     $100.00    $107.08   $113.69   $147.13



               (Proxy Statement Continues on the Following Page)

                                       20
<PAGE>
 
                                   PROPOSAL 2

              RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS
                                        
The Board of Directors has appointed Ernst & Young LLP as independent auditors
for the fiscal year ending December 31, 1998, upon the recommendation of its
Audit Committee.  Ernst & Young LLP has served as auditors for the Company since
1993.  A representative of Ernst & Young LLP will be in attendance at the Annual
Meeting and will have an opportunity to make a statement if the representative
desires to do so and will be available to respond to questions from
stockholders.

Unless marked to the contrary, proxies received will be voted FOR ratification
of the appointment of Ernst & Young LLP as independent auditors for the fiscal
year ending December 31, 1998.

       THE BOARD OF DIRECTORS RECOMMENDS A VOTE IN FAVOR OF PROPOSAL 2.


       COMPLIANCE WITH SECTION 16 OF THE SECURITIES EXCHANGE ACT OF 1934
                                        
Section 16(a) promulgated under the Exchange Act requires executive officers,
directors, and persons who beneficially own more than ten percent (10%) of the
Company's Common Stock to file initial reports of ownership and reports of
changes in ownership of the Company's securities with the SEC.

Based solely on a review of such information and the copies of the filings
furnished by executive officers and directors to the Company, the Company
believes that during fiscal year ended December 31, 1997, all Section 16(a)
filing requirements applicable to the Company's executive officers, directors
and persons who beneficially own more than ten percent (10%) of the Company's
Common Stock were complied with except for Arthur L. Herbst, M.D., a director of
the Company, whose Form 4 was due but not filed in September 1997 with respect
to a purchase of Company Common Stock in August 1997, and C. Raymond Larkin,
Jr., whose entry Form 3 filing inadvertently omitted 2,500 shares of Common
Stock which were purchased in the Company's initial public offering in December
1995.  In addition, the Form 5 for each of Dr. Herbst and Mr. Larkin in respect
of the foregoing reports was due in February 1998 but not filed until March
1998.

                             CERTAIN TRANSACTIONS
                                        
License Agreements.  From 1989 through 1991, the Company sold various long-term
territorial license agreements (the "License Agreements") for the PAPNET(R)
Testing System.  Following mergers of the various entities holding the License
Agreements, there are currently two licensees.  Carl Genberg, a director of the
Company and member of the Compensation Committee, has significant ownership
interests in the two licensees and is an officer and director of Cytology West,
Inc., holder of the License Agreement relating to Arizona, Nevada, Utah and San
Diego County.  The holders of the License Agreements receive royalties on an
annual basis which the Company estimates will be approximately 10% of its United
States revenues over the term of the License Agreements, however, the actual
expense of such royalties may differ from the estimated percentage depending on
variation in geographical origin of Company revenues.  In 1997, the Company's
royalty obligation was equal to approximately 18.9% of the Company's United
States revenues, because a disproportionate share of revenues came from certain
licensed territories.  The Company's aggregate royalty expense incurred under
the License Agreements was approximately $988,000, $286,000 and $87,000 in 1997,
1996 and 1995, respectively.  In accordance with a settlement agreement entered
into in 1995 which clarified previously disputed elements of the License
Agreements, the Company is renegotiating revised licenses with the two licensees
pursuant to which the rights and obligations will be clarified but as to which
the economic terms will not be materially altered except that slides received by
the Company from multistate national laboratories will be deemed to have been
received from the licensed territories pro rata with respect to each territory's
population as a percentage of the entire United States population.  The Restated
Licenses will expire on December 31, 2025.

PFEL Transactions.  Until June 1, 1997, the Company was a party to an exclusive
representation agreement with Papnet (Far East) Ltd. ("PFEL") for the
distribution of the Company's PAPNET(R) Testing System in Asia Pacific markets,
pursuant to which the Company incurred aggregate expenses of approximately
$53,000 in 1997, $142,000 in 1996 and $136,000 in 1995.  Included in such
amounts are management fees paid by the Company in connection 

                                       21
<PAGE>
 
with assistance rendered by PFEL with respect to the establishment of the
Company's Asia Pacific operations center in Hong Kong. Dr. Stephen Ng is the
President and an 18.3% stockholder of PFEL and was also member of the Company's
Board of Directors from 1994 until the Company's Annual Meeting of Stockholders
on May 15, 1997 when his term of office expired. Dr. Ng is also the President of
Compuscreen Medical Diagnostic Centre ("Compuscreen"), owned by New System
International, Ltd., a Hong Kong subsidiary of PFEL ("New System
International"), which was a customer of the Company until the acquisition
described below. The Company recorded approximately $211,000, $531,000 and
$259,000 in revenue from Compuscreen in 1997 (prior to the acquisition
described below), 1996 and 1995, respectively. In an agreement effective as of
June 1, 1997, the Company acquired from PFEL 100% of the stock of New System
International for a net cost of $1,564,000. Dr. Ng served as president of New
System International prior to its acquisition and continues in such capacity as
an employee of the Company at fair market compensation unrelated to any
acquisition payments. As part of the acquisition of New System International,
PFEL paid the Company $800,000 for the right to participate in a royalty of 3%
to 4% based on Company sales in Hong Kong, China and Taiwan over a 15 year
period (the "Royalty Arrangement"). Under the terms of the Royalty Arrangement,
commencing September 2001 and ending September 2005, PFEL may, at its option,
require the Company to repurchase its rights under the Royalty Arrangement for
an aggregate purchase price equal to five times the trailing year's royalty due
(the "Repurchase Option"). The Repurchase Option is payable at the election of
the Company in either cash or in Company Common Stock. If the Repurchase Option
is exercised by PFEL and made payable by the Company in Common Stock, (i) the
price of the Common Stock will be determined based on the average publicly
quoted closing price of the most recent 30 day period prior to exercise of the
Repurchase Option, and (ii) the Company will provide registration rights with
respect to such Common Stock. The Royalty Arrangement contains a provision
providing that in the event of cessation of the Company's Asia Pacific
operations, a termination fee shall be due and payable to PFEL in an amount
equal to $800,000 less the sum of all royalty payments previously paid.

Medical Consulting Agreement.  Dr. Herbst, a director of the Company, has served
as a consultant to the Company in the field of gynecological oncology since
1994.  Dr. Herbst's consulting agreement provides the Company with additional
intellectual resources in the areas of product development, commercialization
and clinical studies of the PAPNET(R) Testing System.  Dr. Herbst's consulting
agreement provided for an annual base fee of $20,000 plus expenses and
additional fees for any certain special projects.  The consulting agreement with
Dr. Herbst expired at the end of 1997.  The Company is currently negotiating a
new consulting agreement with Dr. Herbst which is expected to be substantially
the same as the prior agreement and to have a term ending on December 31, 1999.
The Company paid Dr. Herbst approximately $32,000, $36,000 and $28,000 in 1997,
1996 and 1995, respectively, plus reimbursement of expenses incurred in
connection with such services.

Technical Consulting Arrangement.  Carl Genberg, a director of the Company, has
served as a technical consultant to the Company with respect to matters relating
to product development and analysis of competitors' products.  During 1997 Mr.
Genberg was paid $62,000 by the Company for his services in such capacity, plus
reimbursement of expenses incurred in connection with such services.

Former CEO Employment Agreement.  In connection with the resignation of Mark R.
Rutenberg as President and CEO of the Company, the Company entered into the
Revised Agreement on June 29, 1997 governing his continued employment with the
Company, which will remain effective until November 19, 1998.  Mr. Rutenberg is
a class III director who is standing for re-election to the Board of Directors
at the 1998 Annual Meeting of Stockholders.  The material provisions of the
Revised Agreement provide for Mr. Rutenberg's continuation of employment with
the Company at an annual salary of $200,000 per year and participation in the
Company's executive benefit plans.  The Revised Agreement also provides for a
non-recourse loan to Mr. Rutenberg from the Company in an amount of $600,000
which has been secured by his pledge of 100,000 shares of Company common stock.
The loan is repayable on the earlier of November 30, 1999 or the date which is
ten days after termination of his employment for any reason.  The Revised
Agreement may be terminated for cause or by either party to the Revised
Agreement upon thirty days written notice.  The Revised Agreement provides that
in the event of his voluntary termination prior to November 19, 1998 or if
terminated for cause, Mr. Rutenberg shall receive $598,000; and if terminated
for reasons other than cause, he shall receive in addition to such amount, the
equivalent of his remaining base salary as measured from such termination date
until the expiration date of the Revised Agreement.  The options held by Mr.
Rutenberg to purchase Company stock have also been extended so as to expire
eight and one-half years after the expiration date of the Revised Agreement,
subject to the terms of such stock options as of the execution date of the
Revised Agreement, provided, however, that his Performance Based Option may be
exercised during such extended 

                                       22
<PAGE>
 
period only to the extent vested and exercisable at the expiration date of the
Revised Agreement. Under the terms of the Revised Agreement, the Company agreed
to nominate Mr. Rutenberg for election to the Board of Directors.

The Company believes that the terms of the transactions described in this
section are no less favorable to the Company than the terms it would have
received if the transactions were entered into with parties unaffiliated with
the Company.

                                       23
<PAGE>
 
                                 OTHER MATTERS
                                        
The entire cost of solicitation of proxies will be borne by the Company,
including preparation, assembly and mailing of this Proxy Statement, the proxy
card and other materials furnished to stockholders.  Proxies may be solicited by
mail, personal interview, telephone or telegraph.  Directors, officers and other
employees of the Company may solicit proxies by such methods without additional
compensation.  The Company will reimburse banks, brokerage houses and other
institutions, nominees and fiduciaries for their reasonable expenses incurred in
connection with forwarding proxy material to their principals.  Employees of
D.F. King & Co., Inc.  will solicit proxies at a fee of approximately $2,000
plus out-of-pocket expenses.  American Stock Transfer & Trust Company will also
solicit proxies as one of the services included within their monthly fee as the
transfer agent of the Company.

As of the date of this Proxy Statement, the Company does not intend to present
and has not been informed that any other person intends to present any business
not specified in this Proxy Statement for action at the Annual Meeting.  If any
other matters properly come before the Annual Meeting, proxies will be voted on
such matters in accordance with the judgment of the person or persons authorized
to vote the proxies.

COPIES OF THE COMPANY'S ANNUAL REPORT ON FORM 10-K (INCLUDING FINANCIAL
STATEMENTS THEREOF) FOR THE YEAR ENDED DECEMBER 31, 1997 MAY BE OBTAINED WITHOUT
CHARGE BY CONTACTING THE COMPANY'S INVESTOR RELATIONS DEPARTMENT AT NEUROMEDICAL
SYSTEMS, INC.  TWO EXECUTIVE BOULEVARD, SUFFERN, NY 10901-4164, TELEPHONE (914)
368-3600.


                    SUBMISSION OF STOCKHOLDER PROPOSALS FOR
                INCLUSION IN THE COMPANY'S 1999 PROXY STATEMENT

In accordance with Rule 14a-8 of the SEC under the Exchange Act, stockholders
may present proposals which may be proper subjects for inclusion in the proxy
statement and for consideration at an annual meeting.  To be considered,
proposals must be submitted on a timely basis.  It is presently anticipated that
the proxy for the 1999 Annual Meeting will be mailed on or about April 7, 1999.
Consequently, proposals for the 1999 Annual Meeting must be received by the
Company no later than December 7, 1998.  Proposals, as well as any questions
related thereto, should be submitted in writing to the Secretary of the Company.
Proposals may be included in the proxy statement for the 1999 Annual Meeting if
they comply with certain rules and regulations promulgated by the SEC.

By order of the Board of Directors,

/s/ John B. Henneman, III

JOHN B. HENNEMAN, III
Executive Vice President of US Operations
  Secretary and Chief Legal Officer

Suffern, New York
April 7, 1998

                                       24
<PAGE>
 
FORM OF PROXY - Side 1

NEUROMEDICAL SYSTEMS, INC.

PROXY FOR ANNUAL MEETING OF STOCKHOLDERS MAY 7, 1998

The undersigned hereby appoints Paul R. Sohmer, M.D., John B. Henneman, III and
Mark L. Smith as Proxies, each with the power to appoint his substitute, and
hereby authorizes them, to represent and vote, as designated on the reverse, all
shares of common stock of Neuromedical Systems, Inc.  (the "Company") held of
record by the undersigned on March 5, 1998, at the Annual Meeting of
Stockholders of the Company to be held on May 7, 1998 and any adjournments or
postponements thereof.  The undersigned hereby acknowledges receipt of the
Notice of Annual Meeting of Stockholders and Proxy Statement, dated April 7,
1998, and the 1997 Annual Report to Stockholders.

(Continued and to be Signed on Reverse Side.)
- --------------------------------------------------------------------------------
FORM OF PROXY - Side 2
Please mark your votes as in this example     X
                                          ---------

<TABLE> 
<C>   <S> 
1.    ELECTION OF CLASS III DIRECTORS
      FOR all nominees (except as noted below) ____
      WITHHOLD AUTHORITY to vote for all nominees ____
      Nominees:   Elizabeth Cogan Fascitelli   Mark R. Rutenberg
      INSTRUCTION: To withhold authority to vote for any nominee(s), write the name(s)
      on the line below.
 
     ------------------------------------------------------------------------------
</TABLE> 

2.  Proposal to ratify the appointment of Ernst & Young LLP as the Company's
    independent auditors for the fiscal year ending December 31, 1998:

    FOR ____ AGAINST ____ ABSTAIN ____

Transact such other matters as may properly come before the Annual Meeting.
THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS.  THIS PROXY WILL BE
VOTED AS DIRECTED.  IN THE ABSENCE OF DIRECTION, THIS PROXY WILL BE VOTED FOR
PROPOSALS 1 AND 2.  STOCKHOLDERS ARE URGED TO COMPLETE, SIGN, DATE AND RETURN
THIS PROXY PROMPTLY IN THE ENVELOPE PROVIDED, WHICH REQUIRES NO POSTAGE IF
MAILED WITHIN THE UNITED STATES.

Signature ___________________________________________ Date ___________________,
1998
Print name and title:

Signature ___________________________________________ Date ___________________,
1998
Print name and title:

Note: Please sign exactly as your name appears on this Proxy.  If acting as
executor, administrator, trustee, guardian, etc., please indicate full title as
such when signing.  If a corporation, please sign the full corporate name by
duly authorized officer.  If a partnership, please sign full partnership name by
authorized person.  If shares are held jointly, please have each stockholder
sign.


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