CYGNUS INC /DE/
S-3/A, EX-5.1, 2000-12-22
PHARMACEUTICAL PREPARATIONS
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                                                                     EXHIBIT 5.1

                                 LAW OFFICES OF

                          PILLSBURY MADISON & SUTRO LLP

LOS ANGELES              POST OFFICE BOX 7880                 PALO ALTO
NEW YORK              SAN FRANCISCO, CALIFORNIA 94120       ORANGE COUNTY
SACRAMENTO               TELEPHONE (415) 983-1000             SAN DIEGO
SAN FRANCISCO           TELECOPIER (415) 983-1200             HONG KONG
WASHINGTON, D.C.                                                TOKYO


                                                            December 22, 2000

Cygnus, Inc.
400 Penobscot Drive
Redwood City, CA 94063-4719

         Re:      Registration Statement on Form S-3

Ladies and Gentlemen:

         We are acting as counsel for Cygnus, Inc., a Delaware corporation (the
"Company"), in connection with the registration under the Securities Act of
1933, as amended, of shares of Common Stock, $.001 par value (the "Common
Stock") of the Company, with an aggregate purchase price of up to thirty-three
million dollars ($33,000,000), to be offered and sold by a certain stockholder
of the Company (the "Selling Stockholder"). In this regard we have participated
in the preparation of a Registration Statement on Form S-3 relating to such
shares of Common Stock. (Such Registration Statement, as amended, is herein
referred to as the "Registration Statement.")

         We are of the opinion that the shares of Common Stock to be offered
and sold by the Selling Stockholder have been duly authorized and, upon
delivery thereof and payment therefor, will be legally issued and will be
fully paid and nonassessable.

         We hereby consent to the filing of this opinion as Exhibit 5.1 to the
Registration Statement and to the use of our name under the caption "Legal
Matters" in the Registration Statement and in the Prospectus included therein.

                                                Very truly yours,

                                                PILLSBURY MADISON & SUTRO LLP




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