CELTRIX PHARMACEUTICALS INC
SC 13G, 1998-02-13
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  Schedule 13G

                    Under the Securities Exchange Act of 1934
                              (Amendment No. ___)*



                          Celtrix Pharmaceuticals, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                                  Common Stock
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    151186103
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



                         (Continued on following pages)



                               Page 1 of 12 Pages
                       Exhibit Index Contained on Page 11


<PAGE>


<TABLE>
<CAPTION>
<S>                                                             <C>          <C>
- --------------------------------------------------------                     ---------------------------------------
CUSIP NO. 151186103                                             13 G                   Page 2 of 12 Pages
- --------------------------------------------------------                     ---------------------------------------

- ----------- --------------------------------------------------------------------------------------------------------
1           NAME OF REPORTING
            SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                     Biotechnology Development Fund, LP ("BDF")
                     Tax ID Number:    94-3258409
- ----------- --------------------------------------------------------------------------------------------------------

2           CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                                   (a)   [ ]        (b)   [X]
- ----------- --------------------------------------------------------------------------------------------------------
3           SEC USE ONLY
- ----------- --------------------------------------------------------------------------------------------------------
4           CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware Limited Partnership
- ----------- --------------------------------------------------------------------------------------------------------
            NUMBER OF               5        SOLE VOTING POWER
              SHARES                         1,230,516 shares,  except that BioAsia, the general partner of BDF, and
           BENEFICIALLY                      Kung,  Leung and  Engleman,  members of  BioAsia  may be deemed to have
      OWNED BY EACH REPORTING                shared power to vote these shares.
              PERSON
               WITH
                                    -------- -----------------------------------------------------------------------
                                    6        SHARED VOTING POWER
                                             See response to item 5.
                                    -------- -----------------------------------------------------------------------
                                    7        SOLE DISPOSITIVE POWER
                                             1,230,516 shares,  except that BioAsia, the general partner of BDF, and
                                             Kung,  Leung and  Engleman,  members of  BioAsia  may be deemed to have
                                             shared power to vote these shares.
                                    -------- -----------------------------------------------------------------------
                                    8        SHARED DISPOSITIVE POWER
                                             See response to item 7.
- ----------- --------------------------------------------------------------------------------------------------------
9           AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
            REPORTING PERSON                                                                       1,230,516
- ----------- --------------------------------------------------------------------------------------------------------
10          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
            EXCLUDES CERTAIN SHARES*                                                                [ ]
- ----------- --------------------------------------------------------------------------------------------------------
11          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                   5.84%
- ----------- --------------------------------------------------------------------------------------------------------
12          TYPE OF REPORTING PERSON*
                                                                                                   PN
- ----------- --------------------------------------------------------------------------------------------------------

<FN>
                                       * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<CAPTION>
<S>                                                             <C>          <C>
- --------------------------------------------------------                     ---------------------------------------
CUSIP NO. 151186103                                             13 G                   Page 3 of 12 Pages
- --------------------------------------------------------                     ---------------------------------------

- ----------- --------------------------------------------------------------------------------------------------------
1           NAME OF REPORTING
            SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                     BioAsia Investments, LLC ("BioAsia")
                     Tax ID Number:    94-3258407
- ----------- --------------------------------------------------------------------------------------------------------
2           CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                                   (a)   [ ]        (b)   [X]
- ----------- --------------------------------------------------------------------------------------------------------
3           SEC USE ONLY
- ----------- --------------------------------------------------------------------------------------------------------
4           CITIZENSHIP OR PLACE OF ORGANIZATION

            California  limited  liability company
- ----------- --------------------------------------------------------------------------------------------------------
            NUMBER OF               5        SOLE VOTING POWER
              SHARES                         0
           BENEFICIALLY
     OWNED BY EACH REPORTING
              PERSON
               WITH
                                    -------- -----------------------------------------------------------------------
                                    6        SHARED VOTING POWER
                                             1,230,516  shares,  all of which are directly owned by BDF.  BioAsia is
                                             the general  partner of BDF and may be deemed to have  shared  power to
                                             vote these shares.
                                    -------- -----------------------------------------------------------------------
                                    7        SOLE DISPOSITIVE POWER
                                             0
                                    -------- -----------------------------------------------------------------------
                                    8        SHARED DISPOSITIVE POWER
                                             1,230,516  shares,  all of which are directly owned by BDF.  BioAsia is
                                             the general  partner of BDF and may be deemed to have  shared  power to
                                             vote these shares.
- ----------------------------------- -------- -----------------------------------------------------------------------
9           AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
            REPORTING PERSON                                                                        1,230,516
- ----------- --------------------------------------------------------------------------------------------------------
10          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
            EXCLUDES CERTAIN SHARES*                                             N/A                [ ]
- ----------- --------------------------------------------------------------------------------------------------------
11          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                   5.84%
- ----------- --------------------------------------------------------------------------------------------------------
12          TYPE OF REPORTING PERSON*                                                              PN
- ----------- --------------------------------------------------------------------------------------------------------

<FN>
                                       * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<CAPTION>
<S>                                                             <C>          <C>
- --------------------------------------------------------                     ---------------------------------------
CUSIP NO. 151186103                                             13 G                   Page 4 of 12 Pages
- --------------------------------------------------------                     ---------------------------------------

- ----------- --------------------------------------------------------------------------------------------------------
1           NAME OF REPORTING
            SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                     Frank Kung ("Kung")
                     Tax ID Number:    ###-##-####
- ----------- --------------------------------------------------------------------------------------------------------
2           CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                                   (a)   [ ]        (b)   [X]
- ----------- --------------------------------------------------------------------------------------------------------
3           SEC USE ONLY
- ----------- --------------------------------------------------------------------------------------------------------
4           CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
- ----------- --------------------------------------------------------------------------------------------------------
- ----------------------------------- -------- -----------------------------------------------------------------------
            NUMBER OF               5        SOLE VOTING POWER
              SHARES                         1000 shares
           BENEFICIALLY
     OWNED BY EACH REPORTING
              PERSON
               WITH
                                    -------- -----------------------------------------------------------------------
                                    6        SHARED VOTING POWER
                                             1,230,516  shares,  all of which are directly  owned by BDF.  Kung is a
                                             member of BioAsia and may be deemed to have shared  power to vote these
                                             shares.
                                    -------- -----------------------------------------------------------------------
                                    7        SOLE DISPOSITIVE POWER
                                             1000 shares
                                    -------- -----------------------------------------------------------------------
                                    8        SHARED DISPOSITIVE POWER
                                             1,230,516  shares,  all of which are directly  owned by BDF.  Kung is a
                                             member of BioAsia and may be deemed to have shared  power to vote these
                                             shares.
- ----------------------------------- -------- -----------------------------------------------------------------------
9           AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
            REPORTING PERSON                                                              1,231,516
- ----------- --------------------------------------------------------------------------------------------------------
10          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
            EXCLUDES CERTAIN SHARES*                                            N/A                      [ ]
- ----------- --------------------------------------------------------------------------------------------------------
11          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                   5.84%
- ----------- --------------------------------------------------------------------------------------------------------
12          TYPE OF REPORTING PERSON*
                                                                                                   IN
- ----------- --------------------------------------------------------------------------------------------------------

<FN>
                                        SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<CAPTION>
<S>                                                             <C>          <C>
- --------------------------------------------------------                     ---------------------------------------
CUSIP NO. 151186103                                             13 G                   Page 5 of 12 Pages
- --------------------------------------------------------                     ---------------------------------------

- ----------- --------------------------------------------------------------------------------------------------------
1           NAME OF REPORTING
            SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                     Anselm Leung ("Leung")
                     Tax ID Number:    ###-##-####
- ----------- --------------------------------------------------------------------------------------------------------
2           CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                                   (a)   [ ]        (b)   [X]
- ----------- --------------------------------------------------------------------------------------------------------
3           SEC USE ONLY
- ----------- --------------------------------------------------------------------------------------------------------
4           CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
- ----------- --------------------------------------------------------------------------------------------------------
            NUMBER OF               5        SOLE VOTING POWER
              SHARES                         0 shares
           BENEFICIALLY
     OWNED BY EACH REPORTING
              PERSON
               WITH
                                    -------- -----------------------------------------------------------------------
                                    6        SHARED VOTING POWER
                                             1,230,516  shares,  all of which are directly  owned by BDF. Leung is a
                                             member of BioAsia and may be deemed to have shared  power to vote these
                                             shares.
                                    -------- -----------------------------------------------------------------------
                                    7        SOLE DISPOSITIVE POWER
                                             0 shares
                                    -------- -----------------------------------------------------------------------
                                    8        SHARED DISPOSITIVE POWER
                                             1,230,516  shares,  all of which are directly  owned by BDF. Leung is a
                                             member of BioAsia and may be deemed to have shared  power to vote these
                                             shares.
- ----------------------------------- -------- -----------------------------------------------------------------------
9           AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
            REPORTING PERSON                                                              1,230,516
- ----------- --------------------------------------------------------------------------------------------------------
10          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
            EXCLUDES CERTAIN SHARES*                                            N/A                 [ ]
- ----------- --------------------------------------------------------------------------------------------------------
11          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                   5.84%
- ----------- --------------------------------------------------------------------------------------------------------
12          TYPE OF REPORTING PERSON*
                                                                                                   IN
- ----------- --------------------------------------------------------------------------------------------------------

<FN>
                                       * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<CAPTION>
<S>                                                             <C>          <C>
- --------------------------------------------------------                     ---------------------------------------
CUSIP NO. 151186103                                             13 G                   Page 6 of 12 Pages
- --------------------------------------------------------                     ---------------------------------------

- ----------- --------------------------------------------------------------------------------------------------------
1           NAME OF REPORTING
            SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                     Edgar Engleman
                     Tax ID Number:    ###-##-####
- ----------- --------------------------------------------------------------------------------------------------------
2           CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                                   (a)   [ ]        (b)   [X]
- ----------- --------------------------------------------------------------------------------------------------------
3           SEC USE ONLY
- ----------- --------------------------------------------------------------------------------------------------------
4           CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
- ----------- --------------------------------------------------------------------------------------------------------
            NUMBER OF               5        SOLE VOTING POWER
              SHARES                         0 shares
           BENEFICIALLY
     OWNED BY EACH REPORTING
              PERSON
               WITH
                                    -------- -----------------------------------------------------------------------
                                    6        SHARED VOTING POWER
                                             1,230,516 shares, all of which are directly owned by BDF. Engleman is a
                                             member of BioAsia and may be deemed to have shared  power to vote these
                                             shares.
                                    -------- -----------------------------------------------------------------------
                                    7        SOLE DISPOSITIVE POWER
                                             0 shares
                                    -------- -----------------------------------------------------------------------
                                    8        SHARED DISPOSITIVE POWER
                                             1,230,516 shares, all of which are directly owned by BDF. Engleman is a
                                             member of BioAsia and may be deemed to have shared  power to vote these
                                             shares.
- ----------------------------------- -------- -----------------------------------------------------------------------
9           AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
            REPORTING PERSON                                                              1,230,516
- ----------- --------------------------------------------------------------------------------------------------------
10          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
            EXCLUDES CERTAIN SHARES*                                            N/A            [ ]
- ----------- --------------------------------------------------------------------------------------------------------
11          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                   5.84%
- ----------- --------------------------------------------------------------------------------------------------------
12          TYPE OF REPORTING PERSON*
                                                                                                   IN
- ----------- --------------------------------------------------------------------------------------------------------

<FN>
                                       * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


                                                                    Page 7 of 12

ITEM 1(A).        NAME OF ISSUER

                  Celtrix Pharmaceuticals, Inc.

ITEM 1(B).        ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES

                  3055 Patrick Henry Drive
                  Santa Clara, CA 95054-1815

ITEM 2(A).        NAME OF PERSONS FILING

                  This Statement is filed by Biotechnology  Development Fund, LP
("BDF"), BioAsia Investments, LLC ("BioAsia"), Frank Kung ("Kung"), Anselm Leung
("Leung"),   and  Edgar  Engleman  ("Engleman").   The  foregoing  entities  and
individuals are collectively referred to as the "Reporting Persons."

                  BioAsia is the  general  partner of BDF,  and may be deemed to
have indirect  beneficial  ownership of shares of the issuer  directly  owned by
BDF. Kung, Leung, and Engleman are members of BioAsia, and may be deemed to have
indirect beneficial ownership of the shares of issuer directly owned by BDF.

                  BioAsia  hereby  disclaims  beneficial  ownership of shares of
issuer  directly  owned by BDF  except to the extent of any  indirect  pecuniary
interest  therein.   Keung,  Leung,  and  Engleman  hereby  disclaim  beneficial
ownership  of the  shares  held by BDF  except to the  extent of any  respective
indirect pecuniary interest therein.

ITEM 2(B).        ADDRESS OF PRINCIPAL OFFICE

                  The address for each of the Reporting Persons is:

                  BioAsia Investments LLC 575 High Street,  Suite 201 Palo Alto,
                  CA 94301

ITEM 2(C)         CITIZENSHIP

                  BDF is a Delaware limited partnership, BioAsia is a California
limited  liability  company,  and Kung,  Leung and  Engleman  are United  States
citizens.

ITEM 2(D) AND (E).  TITLE OF CLASS OF SECURITIES AND CUSIP NUMBER

                  Common Stock
                  CUSIP # 151186103

 ITEM 3.          Not Applicable

<PAGE>


                                                                    Page 8 of 12


ITEM 4.  OWNERSHIP

                  (a)      Amount beneficially owned:

                           See Row 9 of cover page for each Reporting Person.

                  (b)      Percent of Class:

                           See Row 11 of cover page for each Reporting Person.

                  (c)      Number of shares as to which such person has:

                                 (i)    Sole  power  to  vote or to  direct  the
                                        vote:

                                        See  Row  5  of  cover   page  for  each
                                        Reporting Person.

                                 (ii)   Shared  power to vote or to  direct  the
                                        vote:

                                        See  Row  6  of  cover   page  for  each
                                        Reporting Person.

                                 (iii)  Sole  power to  dispose or to direct the
                                        disposition of:

                                        See  Row  7  of  cover   page  for  each
                                        Reporting Person.

                                 (iv)   Shared power to dispose or to direct the
                                        disposition of:

                                        See  Row  8  of  cover   page  for  each
                                        Reporting Person.


ITEM 5.           OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

                  Not applicable.

ITEM 6.           OWNERSHIP  OF MORE THAN  FIVE  PERCENT  ON  BEHALF OF  ANOTHER
                  PERSON.

                  Under   certain   circumstances   set  forth  in  the  limited
partnership  agreement  of BDF and the limited  liability  company  agreement of
BioAsia, the general and limited partners of BDF and the members of BioAsia each
may be deemed to have the right to receive dividends from, or the proceeds from,
the sale of shares of the issuer  owned by each such  entity of which they are a
partner.

<PAGE>
                                                                    Page 9 of 12

ITEM 7.           IDENTIFICATION  AND  CLASSIFICATION  OF THE  SUBSIDIARY  WHICH
                  ACQUIRED THE SECURITY  BEING REPORTED ON BY THE PARENT HOLDING
                  COMPANY

                  Not applicable

ITEM 8.           IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

                  Not applicable

ITEM 9.           NOTICE OF DISSOLUTION OF GROUP.

                  Not applicable

ITEM 10.          CERTIFICATION.

                  Not applicable

<PAGE>
                                                                   Page 10 of 12

                                   SIGNATURES

                  After reasonable  inquiry and to the best of our knowledge and
belief,  we certify that the  information  set forth in this  statement is true,
complete and correct.

Dated:  February 6, 1998


                               Biotechnology Development Fund, LP

                               By: BioAsia Investments, LLC, its general partner


                               By:  /s/ Frank Kung
                                   --------------------------------
                                   Frank Kung, Member


                               BIOASIA INVESTMENTS, LLC


                               By:  /s/ Frank Kung
                                   --------------------------------
                                    Frank Kung, Member


                               /s/ Frank Kung
                               ------------------------------------
                               FRANK KUNG


                               /s/ Anselm Leung
                               ------------------------------------
                               ANSELM LEUNG


                               /s/ Edgar Engleman
                               ------------------------------------
                               EDGAR ENGLEMAN


<PAGE>


                                                                   Page 11 of 12

                                  EXHIBIT INDEX


                                                                   Found on
                                                                 Sequentially
Exhibit                                                          Numbered Page
- -------                                                          -------------

Exhibit A:  Agreement of Joint Filing                               Page 12


<PAGE>

                                                                   Page 12 of 12




                                    EXHIBIT A



                            Agreement of Joint Filing

                  The  undersigned  hereby agree that a single  Schedule 13G (or
any amendment thereto) relating to the Common Stock of Celtrix  Pharmaceuticals,
Inc. shall be filed on behalf of each of the undersigned and that this Agreement
shall be filed as an exhibit to such Schedule 13G.

         Executed this 6th day of February, 1998.

                                              Biotechnology Development Fund, LP

                                              By: BioAsia Investments, LLC, its
                                                       general partner
                                                                               
                                                                               
                                              By:  /s/ Frank Kung              
                                                  -----------------------------
                                                  Frank Kung, Member           
                                                                               
                                                                               
                                              BIOASIA INVESTMENTS, LLC         
                                                                               
                                                                               
                                              By:  /s/ Frank Kung              
                                                  -----------------------------
                                                   Frank Kung, Member          
                                                                               
                                                                               
                                              /s/ Frank Kung                   
                                              ---------------------------------
                                              FRANK KUNG                       
                                                                               
                                                                               
                                              /s/ Anselm Leung                 
                                              ---------------------------------
                                              ANSELM LEUNG                     
                                                                               
                                                                               
                                              /s/ Edgar Engleman               
                                              ---------------------------------
                                              EDGAR ENGLEMAN                   





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