FRANKLIN STRATEGIC SERIES
497, 1998-07-31
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o402 STK SAI 1
                          SUPPLEMENT DATED AUGUST 3, 1998
                   TO THE STATEMENT OF ADDITIONAL INFORMATION OF
                       FRANKLIN BIOTECHNOLOGY DISCOVERY FUND
                              DATED SEPTEMBER 15, 1997

The Statement of Additional Information is amended as follows:

I. The section  "Officers and  Trustees" is revised to replace  Trustee David W.
Garbellano with the following:

 Edith E. Holiday (46)
 3239 38th Street, N.W.
 Washington, DC 20016
 Trustee

 Director,  Amerada Hess Corporation and Hercules Incorporated (1993 - present);
 Director,  Beverly  Enterprises,  Inc.  (1995 - present) and H.J. Heinz Company
 (1994 -  present);  director  or  trustee,  as the  case  may be,  of 25 of the
 investment  companies in the Franklin  Templeton Group of Funds;  and formerly,
 Chairman  (1995 - 1997) and Trustee  (1993 - 1997) of National  Child  Research
 Center,  Assistant to the  President of the United  States and Secretary of the
 Cabinet (1990 - 1993), General Counsel to the United States Treasury Department
 (1989 - 1990),  and  Counselor to the  Secretary  and  Assistant  Secretary for
 Public Affairs and Public Liaison - United States Treasury  Department  (1988 -
 1989).

II. The section "Officers and Trustees" is revised to add the following:

 As of February 25, 1998,  the officers and Board  members did not own of record
 or beneficially any shares of the Fund.

III.  The  first  paragraph  under  "How Do I Buy,  Sell  and  Exchange  Shares?
Additional Information on Selling Shares" is replaced with the following:

 SYSTEMATIC  WITHDRAWAL  Plan.  There are no service charges for establishing or
 maintaining a systematic  withdrawal plan. Payments under the plan will be made
 from  the  redemption  of an  equivalent  amount  of  shares  in your  account,
 generally on the 25th day of the month in which a payment is scheduled.  If the
 25th falls on a weekend or holiday,  we will process the redemption on the next
 business day.

IV. The following is added to the end of the section  "Cumulative Total Return,"
found under "How does the Fund Measure Performance?  - Total Return." The figure
below has been  restated to reflect the Fund's  current,  maximum  5.75% initial
sales charge.

 The Fund's cumulative total return for the period from inception (September 15,
 1997) through January 31, 1998, was -8.79%.

V. The  following  sentence  is added to the end of the fifth  paragraph  in the
section "Miscellaneous Information":
 To the best  knowledge of the Fund,  no other person holds  beneficially  or of
 record more than 5% of the Fund's outstanding shares.

VI. The following  new  section  is  added  after  the  section   "Miscellaneous
Information":

- --------------------------------------------------------------------------------
 Financial Statements

 The unaudited financial statements of the Fund for the period ended January 31,
 1998, are as follows:

 FRANKLIN BIOTECHNOLOGY DISCOVERY FUND

 Financial Highlights
                                                              Period Ended
                                                            January 31, 1998
                                                              (unaudited)*
- ----------------------------------------------------------------------------
 Per share operating performance
 (for a share outstanding throughout the period)
 Net asset value, beginning of period .......................      $25.00
                                                                 -----------
 Income from investment operations:
  Net investment loss .......................................        (.05)
  Net realized and unrealized loss ..........................        (.75)
                                                                 -----------
 Total from investment operations ...........................        (.80)
                                                                 -----------
 Less distributions from:
  Net realized gains ........................................        (.05)
                                                                 -----------
 Net asset value, end of period .............................      $24.15
                                                                 ===========
 Total return** .............................................       (3.21%)
 Ratios/supplemental data
 Net assets, end of period (000's) ..........................  $53,228
 Ratios to average net assets:
  Expenses ..................................................        1.48%****
  Expenses excluding waiver and payments by affiliate .......        1.61%****
  Net investment loss .......................................        (.67%)****
 Portfolio turnover rate ....................................       39.49%
 Average commission rate paid*** ............................        $.0314

 *For the period September 15, 1997 (effective date) to January 31, 1998.
 **Total return does not reflect sales commissions or the  contingent  deferred
 sales charge, and is not annualized.
 ***Relates to purchases and sales of equity securities.
 ****Annualized.

<TABLE>
<CAPTION>

 Statement of Investments, January 31, 1998 (unaudited)
<S>                                                               <C>               <C>
  Franklin Biotechnology Discovery Fund                           SHARES            VALUE
- ------------------------------------------------------------------------------------------
 aCommon Stocks 91.4%
  Biomedical 31.8%
  Aviron .............................................            109,800$      2,820,488
  Centocor, Inc.......................................             37,500       1,500,000
  IDEC Pharmaceuticals Corp. .........................             69,800       2,914,150
  Inhale Therapeutic Systems .........................             81,200       2,628,850
  Lifecell Corp. .....................................            420,000       2,205,000
  Synaptic Pharmaceutical Corp. ......................            140,000       1,680,000
  Texas Biotechnology Corp. ..........................            455,700       2,705,719
  Vical, Inc..........................................             30,000         466,875
                                                                               -----------
                                                                               16,921,082
                                                                               -----------
  Delivery Systems 5.4%
  Alkermes, Inc.......................................             50,000       1,212,500
  Aradigm Corp. ......................................            116,600         961,950
  DepoTech Corp. .....................................            182,300         695,019
                                                                               -----------
                                                                                2,869,469
                                                                               -----------
  Diagnostics 3.3%
  Technical Chemicals and Products, Inc. .............            165,000       1,773,750
                                                                               -----------

 Statement of Investments, January 31, 1998 (unaudited) (cont.)
  Franklin Biotechnology Discovery Fund                            SHARES        VALUE
- ------------------------------------------------------------------------------------------
 aCommon Stocks (cont.)
  Drugs 41.2%
  Agouron Pharmaceuticals, Inc. ......................             65,100$      2,262,225
  Cell Therapeutics, Inc. ............................             96,500       1,326,875
  Chiroscience Group, Plc. (United Kingdom) ..........            623,000       2,499,616
  Gilead Sciences, Inc. ..............................             73,000       2,956,500
  Ligand Pharmaceuticals-Class B .....................            170,000       1,870,000
  MedImmune, Inc. ....................................             45,500       2,087,313
  PathoGenesis Corp. .................................             68,000       2,448,000
  Sepracor, Inc. .....................................             25,000         878,125
  Vertex Pharmaceutical, Inc. ........................             72,300       2,837,775
  Zonagen, Inc. ......................................            145,100       2,756,900
                                                                               -----------
                                                                               21,923,329
                                                                               -----------
  Miscellaneous 3.7%
  SYNSORB Biotech, Inc. (Canada)......................            278,000       1,957,410
                                                                               -----------
  Therapeutics 6.0%
  Alteon, Inc. .......................................            115,000       1,035,000
  COR Therapeutics, Inc. .............................             72,300         700,406
  Neurogen Corp. .....................................            100,000       1,475,000
                                                                               -----------
                                                                                3,210,406
                                                                               -----------
  Total Long Term Investments (Cost $53,225,073) .....                         48,655,446
                                                                               -----------


                                                                                              PRINCIPAL
                                                                                               AMOUNT
                                                                                              ----------

 bRepurchase Agreement 8.3%
  Joint Repurchase Agreement, 5.578%, 2/02/98, (Maturity Value $4,394,350) (Cost $4,392,309)
   BancAmerica Robertson Stephens (Maturity Value $342,760)
   Barclays Capital Group, Inc. (Maturity Value $342,760)
   Bear, Stearns & Co., Inc. (Maturity Value $206,534)
   BT Alex Brown, Inc. (Maturity Value $342,759)
   Chase Securities, Inc. (Maturity Value $70,310)
   CIBC Wood Gundy Securities Corp. (Maturity Value $342,760)
   Deutsche Morgan Grenfell/C.J. Lawrence, Inc. (Maturity Value $342,759)
   Donaldson, Lufkin & Jenrette Securities Corp. (Maturity Value $342,759)
   Dresdner Kleinwort Benson, North America, L.L.C. (Maturity Value $342,759)
   Greenwich Capital Markets, Inc. (Maturity Value $342,759)
   Lehman Gov't. Securities (Maturity Value $347,154)
   Paribas Corp. (Maturity Value $342,759)
   SBC Warburg Dillon Read, Inc. (Maturity Value $342,759)
   UBS Securities, L.L.C. (Maturity Value $342,759)
</TABLE>
<TABLE>
<CAPTION>

<S>                                                                                       <C>                     <C>      
    Collateralized by U.S. Treasury Bills and Notes ..                                    $4,392,309              4,392,309
                                                                                                                ------------
  Total Investments (Cost $57,617,382) 99.7% .........                                                           53,047,755
  Securities Sold Short (6.9%) .......................                                                           (3,655,313)
  Other Assets, less Liabilities 7.2% ................                                                            3,835,574
                                                                                                                ------------
  Net Assets 100.0% ..................................                                                          $53,228,016
                                                                                                                ------------
</TABLE>

 aSecurities Sold Short
<TABLE>
<CAPTION>

  ISSUER                                                         SHARES       VALUE
- -------------------------------------------------------------------------------------
<S>                                                              <C>      <C>       
  Icos Corp. .........................................           25,000   $  401,563
  Protein Design Labs, Inc. ..........................           50,000    1,868,750
  Transkaryotic Therapies, Inc. ......................           40,000    1,385,000
                                                                         -----------
  Total (Proceeds $3,918,464) ........................                   $ 3,655,313
                                                                         -----------
</TABLE>

 aNon-income producing.
 bInvestment  is through  participation  in a joint  account  with  other  funds
 managed  by the  investment  advisor.  At  January  31,  1998,  all  repurchase
 agreements had been entered into on January 30, 1998.

                         See notes to financial statements.

 FRANKLIN BIOTECHNOLOGY  DISCOVERY FUND Financial Statements Statement of Assets
 and Liabilities January 31, 1998 (unuadited)
 Assets:
  Investments in securities,
  at value (cost $57,617,382)                        $53,047,755
  Cash                                                   400,411
  Receivables:
   Investment securities sold                          3,918,464
   Capital shares sold                                   486,815
   Deposits with brokers for securities sold short     1,537,161
  Other assets                                            27,991
                                                  --------------------
       Total assets                                   59,418,597
                                                  --------------------
 Liabilities:
  Payables:
   Investment securities purchased                     2,369,686
   Capital shares redeemed                                12,728
  Securities sold short, at value
  (Proceeds $3,918,464)                                3,655,313
  Other liabilities                                      152,854
                                                  --------------------
       Total liabilities                               6,190,581
                                                  --------------------
        Net assets, at value                         $53,228,016
                                                  --------------------
 Net assets consist of:
  Accumulated distributions in excess
  of net investment income                           $  (101,117)
  Net unrealized depreciation                         (4,306,476)
  Accumulated net realized loss                          (70,539)
  Capital shares                                      57,706,148
                                                  --------------------
       Net assets, at value                          $53,228,016
                                                  --------------------
 Net asset value per share
  ($53,228,016 /  2,204,409 shares outstanding)*          $24.15
                                                  --------------------
 Maximum offering price per share
  ($24.15 / 95.50%)                                       $25.29
                                                  --------------------


 Statement of Operations
for the period ended January 31, 1998 (unuadited)
Investment income:
 Interest                                                             $ 122,188
Expenses:
 Management fees (Note 3)                     $94,117
 Administration fees (Note 3)                  13,453
 Distribution fees (Note 3)                    51,512
 Transfer agent fees (Note 3)                  42,666
 Amortization of offering costs                24,460
 Other                                         16,447
                                             -----------
      Total expenses                                                    242,655
      Expenses waived/paid by
 affiliate (Note 3)                                                     (19,350)
                                                                      ----------
       Net expenses                                                     223,305
                                                                      ----------
        Net investment loss                                            (101,117)
                                                                      ----------
Realized and unrealized gains (losses) Net realized gain on:
  Investments                                                            19,463
  Foreign currency transactions                                           2,676
                                                                      ----------
 Net realized gain                                                       22,139
 Net unrealized depreciation                                         (4,306,476)
                                                                      ----------
Net realized and unrealized loss                                     (4,284,337)
                                                                      ----------
Net decrease in net assets resulting
 from operations                                                    $(4,385,454)
                                                                      ----------

*Redemption  price is equal to net asset  value less any  applicable  contingent
deferred sales charge.

                         See notes to financial statements.

                       FRANKLIN BIOTECHNOLOGY DISCOVERY FUND
 Financial Statements (cont.)
 Statement of Changes in Net Assets
 for the period ended January 31, 1998 (unuadited)
<TABLE>
<CAPTION>

                                                                               Period Ended
                                                                             January 31, 1998*
- -----------------------------------------------------------------------------------------------
 Increase (decrease) in net assets:
  Operations:
   <S>                                                                          <C>        
   Net investment loss ......................................................   $ (101,117)
   Net realized gain from investments and foreign currency transactions .....       22,139
   Net unrealized depreciation on investments and translation of
  assets and liabilities denominated in foreign currencies ..................   (4,306,476)
                                                                               -------------
       Net decrease in net assets resulting from operations .................   (4,385,454)
  Distributions to shareholders from:
   Net realized gains .......................................................      (92,678)
  Capital share transactions (Note 2) .......................................   57,706,148
                                                                               -------------
       Net increase in net assets ...........................................   53,228,016
 Net assets:
  Beginning of period .......................................................          --
                                                                               -------------
  End of period .............................................................  $53,228,016
 Undistributed net investment loss included in net assets:
  End of period .............................................................   $ (101,117)
                                                                               -------------
</TABLE>

 *For the period September 15, 1997 (effective date) to January 31, 1998.

                         See notes to financial statements.

 FRANKLIN BIOTECHNOLOGY DISCOVERY FUND

 Notes to Financial Statements (unaudited)

 1. ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES

 The  Franklin   Biotechnology   Discovery   Fund  (the  Fund)  is  a  separate,
 non-diversified  series of Franklin  Strategic Series (the Trust),  which is an
 open-end  investment  company  registered  under the Investment  Company Act of
 1940.
 The Fund seeks capital growth.

 The following summarizes the Fund's significant accounting policies.

 A. SECURITY VALUATION:

 Securities  listed or traded on a  recognized  national  exchange or NASDAQ are
 valued at the latest  reported  sales price.  Over-the-counter  securities  and
 listed  securities for which no sale is reported are valued within the range of
 the latest quoted bid and asked prices.  Securities for which market quotations
 are not readily  available are valued at fair value as determined by management
 in accordance with procedures established by the Board of Trustees.

 B. FOREIGN CURRENCY TRANSLATION:

 Portfolio  securities and other assets and  liabilities  denominated in foreign
 currencies are translated into U.S.  dollars based on the exchange rate of such
 currencies  against U.S. dollars on the date of valuation.  Purchases and sales
 of securities and income items denominated in foreign currencies are translated
 into U.S. dollars at the exchange rate in effect on the transaction date.

 The Fund does not separately  report the effect of changes in foreign  exchange
 rates from  changes in market  prices on  securities  held.  Such  changes  are
 included in net realized and unrealized gain or loss from investments.

 Realized  foreign  exchange  gains  or  losses  arise  from  sales  of  foreign
 currencies,  currency gains or losses realized between the trade and settlement
 dates on  securities  transactions  and the  difference  between  the  recorded
 amounts of  dividends,  interest,  and foreign  withholding  taxes and the U.S.
 dollar  equivalent of the amounts  actually  received or paid.  Net  unrealized
 foreign  exchange gains and losses arise from changes in foreign exchange rates
 on  foreign  denominated  assets and  liabilities  other  than  investments  in
 securities held at the end of the reporting period.

 C. SECURITIES SOLD SHORT:

 The Fund is engaged in selling  securities  short,  which obligates the Fund to
 replace a security  borrowed  by  purchasing  the same  security at the current
 market  value.  The  Fund  would  incur a loss  if the  price  of the  security
 increases  between  the date of the  short  sale and the date on which the Fund
 replaces the borrowed  security.  The Fund would realize a gain if the price of
 the security declines between those dates.

 The Fund is required to establish a margin  account with the broker lending the
 security sold short.  While the short sale is  outstanding,  the broker retains
 the  proceeds of the short sale and the Fund must  maintain a deposit  with the
 broker  consisting of cash and  securities  having a value equal to a specified
 percentage of the value of the securities sold short.

 D. INCOME TAXES:

 No  provision  has been made for income taxes  because the Fund's  policy is to
 qualify as a regulated  investment  company under the Internal Revenue Code and
 distribute all of its taxable income.

 E. SECURITY TRANSACTIONS, INVESTMENT INCOME, EXPENSES AND DISTRIBUTIONS:

 Security  transactions  are  accounted  for on trade date.  Realized  gains and
 losses on security  transactions  are  determined on a specific  identification
 basis.  Interest  income and  estimated  expenses are accrued  daily.  Dividend
 income and distributions to shareholders are recorded on the ex-dividend date.

 Common  expenses  incurred by the Trust are allocated  among the funds based on
 the ratio of net assets of each fund to the combined net assets. Other expenses
 are charged to each fund on a specific identification basis.

 F. OFFERING COSTS:

 Offering costs are amortized on a straight-line basis over twelve months.

 G. ACCOUNTING ESTIMATES:

 The preparation of financial  statements in accordance with generally  accepted
 accounting  principles  requires  management to make estimates and  assumptions
 that affect the reported  amounts of assets and  liabilities at the date of the
 financial statements and the amounts of income and expense during the reporting
 period. Actual results could differ from those estimates.

 2. CAPITAL STOCK

 At January 31, 1998, there were an unlimited number of shares  authorized ($.01
 par value). Transactions in the Fund's shares were as follows:

                                                              Period Ended
                                                               January 31,
                                                                  1998*
                                                       -------------------------
                                                          Shares       Amount
                                                       -------------------------
 Shares sold ..........................................  2,319,379  $60,531,850
 Shares issued in reinvestment of distributions .......      3,077       72,112
 Shares redeemed ......................................   (118,047)  (2,897,814)
                                                       -------------------------
 Net increase .........................................  2,204,409  $57,706,148

 *For the period September 15, 1997 (effective date) to January 31, 1998.

 3. TRANSACTIONS WITH AFFILIATES

Certain  officers of the Fund are also  officers  and/or  directors  of Franklin
Advisers, Inc. (Advisers), Franklin/Templeton Distributors, Inc. (Distributors),
Franklin Templeton Services, Inc. (FT Services) and Franklin/Templeton  Investor
Services,  Inc. (Investor  Services),  the Fund's investment manager,  principal
underwriter, administrative manager and transfer agent, respectively.

 The Fund pays an investment management fee to Advisers based on the average net
 assets of the Fund as follows:

    Annualized
    Fee Rate   Average Daily Net Assets  
    ---------------------------------------------------------------
    0.625%     First $100 million  
    0.500%     Over $100 million, up to and including $250 million
    0.450%     Over $250 million, up to and including $10 billion

 Fees are further reduced on net assets over $10 billion.

 The Fund pays an administrative  fee to FT Services based on the Fund's average
 net assets as follows:

     Annualized
     Fee Rate      Average Daily Net Assets  
     -------------------------------------------------------------------
     0.150%        First $200 million  
     0.135%        Over $200 million, up to and including $700 million
     0.100%        Over $700 million, up to and including $1.2 billion
     0.075%        Over $1.2 billion

 Advisers  agreed in advance to waive  management fees for the Fund, as noted in
 the Statement of Operations.

 The Fund reimburses  Distributors up to 0.35% per year of its average daily net
 assets for costs incurred in marketing the Fund's shares.

 Distributors  received  net  commission  from  sales of the  Fund's  shares  of
 $219,649.  The Fund paid transfer  agent fees of $42,666,  of which $28,842 was
 paid to Investor Services. At January 31, 1998, Franklin Resources,  Inc. owned
 5% of the Fund.

 4. INCOME TAXES

 At January  31,  1998,  the net  unrealized  depreciation  based on the cost of
 investments for income tax purposes of $54,017,955 was as follows:

     Unrealized appreciation ..........   $ 2,651,584
     Unrealized depreciation ..........   $(7,277,097)
                                         --------------
     Net unrealized depreciation ......   $(4,625,513)

 Net  investment  income  differs  for  financial  statement  and  tax  purposes
 primarily due to differing treatments of foreign currency transactions.

 Net realized  capital  gains differ for  financial  statement  and tax purposes
 primarily  due to  differing  treatment  of wash  sales  and  foreign  currency
 transactions.

 5. INVESTMENT TRANSACTIONS

 Purchases and sales of securities  (excluding  short-term  securities)  for the
 period  ended  January  31,  1998,  aggregated   $58,700,584  and  $12,854,627,
 respectively.

VII. The following replaces the definition of "Offering Price" under the section
"Useful Terms and Definitions":
 Offering Price - The public  offering price is based on the Net Asset Value per
 share and includes the front-end  sales  charge.  The maximum  front-end  sales
 charge is 5.75%.


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