FRANKLIN STRATEGIC SERIES
497, 2000-01-20
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O FSS2 P-3

                       SUPPLEMENT DATED JANUARY 20, 2000
                             TO THE PROSPECTUS OF

                           FRANKLIN STRATEGIC SERIES
         (FSS2 - FRANKLIN BIOTECHNOLOGY DISCOVERY, GLOBAL HEALTH CARE,
              GLOBAL COMMUNICATIONS AND NATURAL RESOURCES FUNDS)
                            DATED SEPTEMBER 1, 1999

The prospectus is amended as follows:

I. Under the "Goal and Strategies" discussion for the Biotechnology Fund, the
second paragraph on page 3 is revised to read:

 When the fund's assets total $500 million, no new accounts, other than
 retirement plan accounts, will be accepted. If you are a shareholder of
 record at that time, you will be able to continue to add to your existing
 account through new purchases, including purchases through reinvestment of
 dividends or capital gains distributions. The fund reserves the right to
 modify this policy at any time.

II. The first paragraph of the section "Income and capital gains
distributions" on page 50 is replaced with the following:

 Each fund intends to pay a dividend at least annually representing
 substantially all of its net investment income and any net realized capital
 gains. The amount of these distributions will vary and there is no guarantee
 any fund will pay dividends.

III. The following sentence is added after the minimum investments table on
page 57:

 Please note that you may only buy shares of a fund eligible for sale in your
 state or jurisdiction.

IV. In the Selling Shares table on page 63 the section "By Wire" is replaced
with the following:

- ----------------------------------------------------------------------
 [Insert graphic    You can call or write to have redemption
 of three lightning proceeds sent to a bank account. See the
 bolts]             policies above for selling shares by mail or
                    phone.
 BY ELECTRONIC
 FUNDS              Before requesting to have redemption proceeds
 TRANSFER (ACH)     sent to a bank account, please make sure we have
                    your bank account information on file. If we do
                    not have this information, you will need to send
                    written instructions with your bank's name and
                    address, a voided check or savings account
                    deposit slip, and a signature guarantee if the
                    ownership of the bank and fund accounts is
                    different.

                    If we receive your request in proper form by
                    1:00 p.m. Pacific time, proceeds sent by ACH
                    generally will be available within two to three
                    business days.
- ----------------------------------------------------------------------

V. The section "Sales charge waivers" on page 56 is replaced with the
following:

 SALES CHARGE WAIVERS Class A shares may be purchased without an initial sales
 charge or CDSC by various individuals, institutions and retirement plans or
 by investors who reinvest certain distributions and proceeds within 365 days.
 Certain investors also may buy Class C shares without an initial sales
 charge. The CDSC for each class may be waived for certain redemptions and
 distributions. If you would like information about available sales charge
 waivers, call your investment representative or call Shareholder Services at
 1-800/632-2301. For information about retirement plans, you may call
 Retirement Plan Services at 1-800/527-2020. A list of available sales charge
 waivers also may be found in the Statement of Additional Information (SAI).

VI. The section "Dealer compensation" on page 66 is replaced with the
following:

 DEALER COMPENSATION Qualifying dealers who sell fund shares may receive sales
 commissions and other payments. These are paid by Franklin Templeton
 Distributors, Inc. (Distributors) from sales charges, distribution and
 service (12b-1) fees and its other resources.

                                     CLASS A      CLASS B    CLASS C
- ----------------------------------------------------------------------

 COMMISSION (%)                          -          4.00      2.00

 Investment under $50,000             5.00             -         -

 $50,000 but under $100,000           3.75             -         -

 $100,000 but under $250,000          2.80             -         -

 $250,000 but under $500,000          2.00             -         -

 $500,000 but under $1 million        1.60             -         -

 $1 million or more              up to 1.001           -         -

 12B-1 FEE TO DEALER                  0.252         0.253     1.004

 A dealer commission of up to 1% may be paid on Class A NAV purchases by
 certain retirement plans1 and on Class C NAV purchases. A dealer commission
 of up to 0.25% may be paid on Class A NAV purchases by certain trust
 companies and bank trust departments, eligible governmental authorities, and
 broker-dealers or others on behalf of clients participating in comprehensive
 fee programs.

 1. During the first year after purchase, dealers may not be eligible to
 receive the 12b-1 fee.
 2. The Biotechnology Fund and Natural Resources Fund may each pay up to 0.35%
 to Distributors or others, out of which 0.10% generally will be retained by
 Distributors for its distribution expenses. The Biotechnology Fund will not
 reimburse Distributors the additional 0.10% during periods when the fund is
 closed to new investors.
 3. Dealers may be eligible to receive up to 0.25% from the date of purchase.
 After 8 years, Class B shares convert to Class A shares and dealers may then
 receive the 12b-1 fee applicable to Class A.
 4. Dealers may be eligible to receive up to 0.25% during the first year after
 purchase and may be eligible to receive the full 12b-1 fee starting in the
 13th month.

VII. The section "Statements and reports" on page 64 is replaced with the
following:

 STATEMENTS AND REPORTS You will receive quarterly account statements that
 show all your account transactions during the quarter. You also will receive
 written notification after each transaction affecting your account (except
 for distributions and transactions made through automatic investment or
 withdrawal programs, which will be reported on your quarterly statement). You
 also will receive the fund's financial reports every six months. To reduce
 fund expenses, we try to identify related shareholders in a household and
 send only one copy of the financial reports. If you need additional copies,
 please call 1-800/DIAL BEN.

 If there is a dealer or other investment representative of record on your
 account, he or she also will receive copies of all notifications and
 statements and other information about your account directly from the fund.

               Please keep this supplement for future reference.







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