OPHIDIAN PHARMACEUTICALS INC
SC 13D, 1999-03-11
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>   1

                                        
                       SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                  SCHEDULE 13D
                   Under the Securities Exchange Act of 1934

                         OPHIDIAN PHARMACEUTICALS, INC.
                                (Name of Issuer)

                         Common Stock, $.025 par value
                         (Title of Class of Securities)

                                   683725105
                                 (CUSIP Number)

                              Michael D. Rosenthal
                         SONNENSCHEIN NATH & ROSENTHAL
                                8000 Sears Tower
                            Chicago, Illinois  60606
                           Telephone:  (312) 876-8000
                 (Name, Address and Telephone Number of Persons
               Authorized to Receive Notices and Communications)


                               February 10, 1999
            (Date of Event which Requires Filing of this Statement)


     If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(b)(3) or (4), check the following box [ ]


                        (Continued on following page(s))





                               Page 1 of 6 Pages

<PAGE>   2

CUSIP NUMBER  683725105

- --------------------------------------------------------------------------------
1.   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
        Rex James Bates

- --------------------------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IN A MEMBER OF A GROUP 
                                                                      (a)  [ ]
                                                                      (b)  [ ]

- --------------------------------------------------------------------------------
3    SEC USE ONLY

- --------------------------------------------------------------------------------
4    SOURCE OF FUNDS*                                                 PF

- --------------------------------------------------------------------------------
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS
     IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)                        [ ]

- --------------------------------------------------------------------------------
6    CITIZENSHIP OR PLACE OF ORGANIZATION                        United States

- --------------------------------------------------------------------------------
                 :  (7)  SOLE VOTING POWER 
                 :         432,028 
                 :
                 ---------------------------------------------------------------
NUMBER OF        :
SHARES           :  (8)  SHARED VOTING POWER BENEFICIALLY  
OWNED BY EACH    :       -0-
REPORTING        :                                                              
PERSON WITH      :--------------------------------------------------------------
                 : 
                 :  (9)  SOLE DISPOSITIVE POWER
                 :       512,028
                 :
                 :--------------------------------------------------------------
                 :
                 :  (10) SHARED DISPOSITIVE POWER
                 :       -0-
                 :
- --------------------------------------------------------------------------------
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 
     432,028
- --------------------------------------------------------------------------------
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES 
     CERTAIN SHARES                                         [X]
                                                            
- --------------------------------------------------------------------------------
13   PERCENT OF CLASS REPRESENTED BY MOUNT IN ROW (11)                 4.7%

- --------------------------------------------------------------------------------
14   TYPE OF REPORTING PERSON                               IN

- --------------------------------------------------------------------------------


                                        
                               Page 2 of 6 Pages
                                        
<PAGE>   3
                                     
Item 1.   Security and Issuer

     This Schedule 13-D relates to the class of common stock, $.025 par value
(the "Common Stock"), of Ophidian Pharmaceuticals, Inc. a Wisconsin corporation
(the "Issuer"), with its principal offices located at 5445 East Cheryl Parkway,
Madison, Wisconsin  53711.

Item 2.   Identity and Background

     Mr. Bates's principal address is 32 Sunset Road, Bloomington, Illinois
61701. Mr. Bates is trustee and a beneficiary of the Rex James Bates Trust (the
"Trust").  Mr. Bates is retired.

     Mr. Bates has not, during the last five years, been convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors).  In addition,
Mr. Bates has not, during the past five years, been a party to a civil
proceeding of a judicial or administrative body of competent jurisdiction and as
a result of such proceeding was or is subject to a judgment, decree or final
order enjoining future violations of, or prohibiting or mandating activities
subject to, federal or state securities laws or finding any violation with
respect to such laws.

     Mr. Bates is a citizen of the United States of America.

Item 3.   Source and Amount of Funds or Other Consideration

     On February 10, 1999 the Trust purchased 310,000 shares of Common Stock
from Sean B. Carroll, a founder of the Company, for a purchase price of $1.75
per share.  The Trust used cash in the trust to acquire such shares.

Item 4.   Purpose of Transaction

     The securities listed in Item 5 are held for investment purposes.  Subject
to availability and price, and subject to applicable laws and regulations, Mr.
Bates (or the Trust) may acquire additional shares of Common Stock or dispose of
shares of Common Stock owned by him or it at any time or from time to time. The
acquisition described in Item 3 was accomplished, in part, in order to reduce
Dr. Carroll's ownership in the Company.  This allowed Dr. Carroll to comply with
certain limitations on Dr. Carroll's imposed by his employer, and is designed to
facilitate his closer involvement in the Company's scientific affairs.

     Except as set forth in this Item 4, the Mr. Bates has no other present
plans or proposals that relate to or that could result in any of the actions
specified in clauses (a) through (j) of Item 4 of Schedule 13D.

Item 5.   Interest in Securities of the Issuer

     (a)  Mr. Bates beneficially owns 432,178 shares of Common Stock, consisting
of (i) 



                               Page 3 of 6 Pages


<PAGE>   4


387,878 shares owned by the Trust, (ii) 35,000 shares issuable upon the exercise
of currently vested options granted to Mr. Bates pursuant to the Company's 1992
Stock Option Plan (the "Options") and (iii) 9,150 shares issuable upon the
exercise of warrants (the "Warrants") owned by the Trust. In addition, Mr. Bates
has the power to dispose of 80,000 shares held by Susan Stein Elemendorf (the
"Elemendorf Shares"), but disclaims beneficial ownership, and the filing of this
Schedule 13D shall not constitute an admission by Mr. Bates that he is the
beneficial owner of such shares.

     Mr. Bates has beneficial ownership of 4.7% of the outstanding shares of
Common Stock, and if the Elemendorf Shares were considered to be beneficially
owned by Mr. Bates he would own 5.5% of the outstanding shares of Common Stock.
This amount is based upon 9,223,018 shares of Common Stock being outstanding (as
reported by the Company in its Proxy Statement on Schedule 14A dated February
23, 1999) and, as required pursuant to Rule 13d-3, treats all warrants and
options beneficially owned by Mr. Bates which are exercisable within sixty days
of the date hereof (but no other options or warrants) as having been exercised
on the date hereof.

     (b) Mr. Bates has sole voting and dispositive power over all securities
owned directly by him (which does not include the Elemendorf Shares).  Mr. Bates
has dispositive power, but not voting power, over the Elemendorf Shares.

     (c) Except as noted in Item 3, above, Mr. Bates has not acquired beneficial
ownership of any additional shares of Common Stock during the past 60 days.


Item 6.   Contracts, Arrangements, Understandings or Relationships With Respect
          to Securities of the Issuer Mr. Bates serves as a director of the
          Company.

     Attached as Exhibit A hereto is the form of purchase agreement, including
exhibits thereto, which were executed in connection with the transactions
described in Item 3, above.

     The Options entitle Mr. Bates to purchase:


- -    25,000 shares of Common Stock at an exercise price of $2.00 per share,
     which Options expire in July 2006;

- -    5,000 shares of Common Stock at an exercise price of $4.50 per share,
     which Options expire in January 2006; and

- -    5,000 shares of Common Stock at an exercise price of $5.50 per share,
     which Options expire in January 2007.


     The Warrants entitle the Trust to purchase shares at a price of $7.32 per
share (subject to adjustment) and expire on May 7, 2003.  Commencing May 7,
2000, the Warrants are subject 


                               Page 4 of 6 Pages

<PAGE>   5


to redemption by the Company, in whole but not in part, at a price of $.10 per
Warrant on 30 days prior written notice provided that the average closing bid
price of the Common Stock on the Nasdaq Small Cap Market equals or exceeds
$14.64 per share for any 20 trading days within a period of 30 consecutive
trading days ending on the fifth trading day prior to the date of the notice of
redemption.  The form of Warrant Certificate and the form of Warrant Agreement
pursuant to which the Warrants were issued are included as Exhibits B and C
hereto, respectively, and are incorporated by reference from the Company's
Registration Statement on Form S-1, as amended, effective May 7, 1998,
Registration No. 333-33219 (the "Registration Statement").

     Other than as described herein, Mr. Bates does not have any other contract,
arrangement or understanding with respect to the Common Stock.


Item 7.   Material to be Filed as Exhibits

Exhibit Number           Exhibit

     A.        Form of Stock Purchase Agreement.

     B.        Form of Warrant Certificate, filed as Exhibit 4.2 to the
               Registration Statement, and incorporated herein by reference in
               its entirety.

     C.        Form of Warrant Agreement, filed as Exhibit 4.4 to the
               Registration Statement, and incorporated herein by reference in
               its entirety.


                               Page 5 of 6 Pages

<PAGE>   6

                                   SIGNATURE


     After reasonable inquiry and to the best of my knowledge and belief, each
of the undersigned certifies that the information set forth in this statement is
true, complete and correct.



Dated: February 24, 1999

                                                       /s/ Rex James Bates
                                                       -------------------------
                                                       REX JAMES BATES




                               Page 6 of 6 Pages


<PAGE>   1
                                                                    EXHIBIT 99.a

                               PURCHASE AGREEMENT



     THIS PURCHASE AGREEMENT (the "Agreement") dated as of February __, 1999 by
and between ________________ ("Buyer") and Sean B. Carroll, an individual
residing in the State of Wisconsin ("Seller").


                                R E C I T A L S:

     A.   Seller owns of record and beneficially __ shares (the "Shares") of the
Common Stock, par value $.0025 per share ("Common Stock") of Ophidian
Pharmaceuticals, Inc., a Wisconsin corporation ("Ophidian").

     B.   Seller desires to sell the Shares to Buyer and Buyer desires to buy
the Shares from Seller, all upon the terms and subject to the conditions set
forth herein.

     C.   In consideration of the recitals (which are deemed to be a part of
this Agreement) and of the respective representations, warranties, covenants,
agreements and conditions contained herein, Buyer and Seller hereby agree as
follows:

                              A G R E E M E N T S

1.   Purchase and Sale of Shares; Closing.

     1.1. Purchase and Sale.  Upon the terms and subject to the conditions set
forth in this Agreement, Seller agrees to sell all of Seller's right, title and
interest in and to the Shares to Buyer and Buyer hereby agrees to purchase the
Shares from Seller.  The purchase price for the Shares shall be $1.75 per share
resulting in the aggregate purchase price of $_________ (the aggregate purchase
price being referred to herein as the "Purchase Price").

     1.2. Closing.  The closing (the "Closing") of the purchase and sale of the
Shares hereunder shall occur by the following method unless otherwise agreed to
by the parties in writing.  Within 24 hours of Buyer's receipt of confirmation
from Ophidian's Transfer Agent, Continental Stock Transfer & Trust Company, New
York, New York (which in no event shall be provided prior to the satisfaction of
the conditions set forth in Section 4.1 hereof) that the Transfer Agent has
received (a) certificates representing the Shares, duly endorsed by Seller in
blank or accompanied by appropriate stock powers endorsed, and (b) written
instruction from Ophidians legal counsel directing the Transfer Agent to
transfer the Shares from Seller to Buyer, Buyer shall pay the Purchase Price in
full to Seller by wire transfer to the account specified by Seller in Exhibit A
hereto.  For purposes of this Agreement, the "Closing Date" shall be the date on
which Seller receives the Purchase Price in the account identified on Exhibit A
hereto.


<PAGE>   2


     1.3  Certain Definitions.  For purposes of this Agreement, the term:

          (a)  "Lien" shall mean all title defects, charges, claims,
     restrictions, liens, pledges, security interests, mortgages, conditional
     sale or other title retention agreements, assessments, covenants,
     restrictions, rights of first refusal, and other burdens, options,
     restrictions or encumbrances of any kind but shall not include the
     restriction against resale of any securities except in compliance with the
     registration requirements pursuant to the Securities Act of 1933, as
     amended (the "Securities Act"), and any applicable state securities laws or
     pursuant to applicable exemptions thereto; and

          (b)  "Person" shall mean an individual, corporation, limited liability
     company, partnership, joint venture, association, trust, unincorporated
     organization or, as applicable, any other entity.

2.   Seller's Representations, Warranties and Covenants.

     Seller represents and warrants to Buyer that:

     2.1. Authority of Seller.  Seller has all necessary right, capacity, power
and authority to enter into, execute and deliver this Agreement and perform its
obligations hereunder and the execution, delivery and performance of this
Agreement by Seller does not and will not (i) conflict with or result in
(including following notice, lapse of time or both) a breach, violation or
default of (x) any law, statute, rule or regulation to which Seller or the
Shares is subject (other than generally applicable federal and state securities
laws) or (y) any agreement, instrument, order, judgment or decree by which
Seller or the Shares is bound or subject, (ii) require the consent, waiver,
authorization or approval of any governmental or regulatory authority or of any
other Person which has not been previously obtained or (iii) result in the
creation of any Lien with respect to the Shares.

     2.2 Restricted Shares.  The Shares to be purchased by Buyer are restricted
shares acquired by Seller in one or more private transactions not involving a
public offering.  The Shares will continue to be restricted shares following the
closing of this transaction and Buyer will be prohibited from reselling the
Shares other than in compliance with the registration requirements of the
Securities Act and any applicable state securities laws or an applicable
exemption therefrom.  Under Rule 144, Buyer may not use, employ or claim
Seller's holding period for the Shares in attempting to comply with Rule 144, in
other words, the Buyer's holding periods required under Rule 144 for the Shares
will commence on the Closing Date.

     2.3 Binding Effect.  This Agreement constitutes a valid and binding
obligation of the Seller, enforceable in accordance with its terms.


                                      -2-

<PAGE>   3


     2.4 Ownership of Shares.  All of the Shares are beneficially owned by
Seller, free and clear of all Liens and no Person has any option or other right
to acquire all or any of the Shares or any right, title or interest in or with
respect to the Shares from Seller.  Upon delivery of the certificates
representing the Shares pursuant to this Agreement, the Buyer will acquire good,
valid and marketable title to the Shares, free and clear of all Liens other than
the Lock-up (as defined in Section 4.2(d) below).

     2.5 Sale Decision.  Seller is making and has made its decision to sell the
Shares pursuant to this Agreement based upon his own investigation and judgment
with respect to the value of the Shares.  Seller is one of the principal
stockholders of Ophidian and is fully acquainted with, and has had an
opportunity to ask questions and receive answers from Ophidian, regarding its
financial position, business and prospects, and he has received all the
information he considers necessary or appropriate for deciding whether to sell
the Shares.  Seller has not relied upon, and hereby disclaims, any
representation or warranty made by Buyer, except as explicitly set forth herein.

     2.6  Accredited Investor.  Seller is an "accredited investor" within the
meaning of Rule 501 of Regulation D under the  Act of 1933, as presently in
effect.  Seller has such knowledge and experience in financial and business
matters that he is capable of evaluating the merits and risks of the proposed
disposition of the Shares.

     2.7 Public Documents.  Seller represents that he has been provided and has
reviewed a copy of Ophidian's annual report on SEC Form 10-K (the "10-K") for
the fiscal year ended September 30, 1998.  To the actual present knowledge of
Seller, the 10-K, as of the date hereof, does not contain any untrue statement
of material fact or omit to state any material fact required to be stated
therein or necessary in order to make the statements therein not misleading, and
there has not been any event which has occurred since the date of the 10-K which
is reasonably likely to have a material adverse effect on Ophidian's business,
properties, operations, condition (financial or otherwise) or prospects.

     2.8 No Broker or Finder.  Seller has engaged no broker or finder in
connection with this Agreement or the transactions contemplated hereby.

3.   Buyer's Representations, Warranties and Covenants.

     Buyer represents and warrants to Seller that:

     3.1. Authority of Buyer.  To the extent that the Buyer is a trust, the
execution, delivery and performance by Buyer of this Agreement have been duly
authorized by Buyer.  Buyer has all necessary right, power, capacity and
authority to enter into, execute and deliver this Agreement and perform its
obligations hereunder and the execution, delivery and performance of this
Agreement does not and will not (i) conflict with or result in (including
following notice, lapse of time or both) a breach, violation or default of (x)
in the case of a Buyer which is a trust, Buyer's trust agreement, (y) any law,
statute, rule or regulation to 


                                      -3-
<PAGE>   4


which Buyer is subject or (z) any agreement, instrument, order, judgment or
decree by which Buyer is bound or subject or (ii) require the consent, waiver,
authorization or approval of any governmental authority or of any other Person.

     3.2 Restricted Shares.  Buyer acknowledges that the Shares are  subject to
certain restrictions and that Buyer will be prohibited from reselling the Shares
other than in compliance the registration requirements under the Securities Act
and any applicable state Securities laws or an applicable exemption therefrom.
Under Rule 144, Buyer may not use, employ or claim Seller's holding period for
the Shares in attempting to comply with Rule 144, in other words, the required
holding periods under Rule 144 for the Shares will commence on the closing Date.
Buyer further acknowledges that the certificates representing the Shares
transferred by Seller to Buyer will bear legends confirming the restrictions on
the re-sale of the Shares.

     3.3 Binding Effect.  This Agreement constitutes a valid and binding
obligation of the Buyer, enforceable in accordance with its terms.

     3.4 Sale Decision.  Buyer is making and has made a decision to purchase the
Shares pursuant to this Agreement based upon his or its own investigation and
judgment with respect to the value of the Shares.  Buyer is, or in the case of a
trust has a trustee who is, a principal stockholder and/or director of Ophidian.
Buyer, or its trustee, is fully acquainted with, and has had an opportunity to
ask questions and receive answers from Ophidian, regarding Ophidian's financial
position, business and prospects.  Buyer has received all the information it
considers necessary or appropriate for deciding whether to purchase the Shares.
Buyer has not relied upon, and hereby disclaims, any representation or warranty
made by Seller, except as explicitly set forth herein.

     3.5 Accredited Investor Status; Investment Intent.   Buyer is an
"accredited investor" within the meaning of Rule 501 of Regulation D under the
Act of 1933, as presently in effect. If Buyer is an individual, his net worth
along with the net worth of his spouse exceeds $1 million or his individual
income has exceeded $200,000 (or $300,000 with his spouse) for each of the past
two years and he expects to have income in excess of such levels for the current
year.  If Buyer is a trust, its assets exceed $5,000,000, it was not formed for
the purpose of investing in Ophidian and its trustee is a sophisticated person.
Buyer has such knowledge and experience in financial and business matters that
he or it is capable of evaluating the merits and risks of the proposed
disposition of the Shares.  Buyer is purchasing the Shares for investment
purposes, and not with a view to the resale or distribution of any part of the
Shares.  The Buyer does not have any contract, undertaking, agreement or
arrangement with any Person to sell, transfer or grant participations to any
third person, with respect to the Shares.

     3.6 Public Documents.  Buyer represents that he or it has been provided and
has reviewed a copy of the 10-K for the fiscal year ended September 30, 1998.
To the actual present knowledge of Buyer, the 10-K, as of the date hereof, does
not contain any untrue 


                                      -4-
<PAGE>   5

statement of material fact or omit to state any material fact required to be
stated therein or necessary in order to make the statements therein not
misleading, and there has not been any event which has occurred since the date
of the 10-K which is reasonably likely to have a material adverse effect on
Ophidian's business, properties, operations, condition (financial or otherwise)
or prospects.

     3.7  No Broker or Finder.  Buyer has engaged no broker or finder in
connection with this Agreement or the transactions contemplated hereby.

4.   Conditions to Closing.

     4.1 Conditions to Obligations of Buyer.  The obligations of Buyer hereunder
are subject to the satisfaction at or prior to the Closing of the following
conditions, unless waived by the Buyer:

          (a)  Performance. Each of the covenants and obligations of Seller to
     be performed at or prior to the Closing shall have been duly performed;

          (b)  Representations and Warranties.  Each representation and warranty
     of Seller shall be true and correct as of the Closing, as if such
     representation and warranty had been made at such time, and Buyer shall
     have received a certificate to that effect in a form attached hereto as
     Exhibit B.

          (c)  No Litigation.  There shall be no injunction or court order
     restraining consummation of the transactions contemplated hereby or any
     part thereof, and there shall be no pending or threatened action or
     proceeding by or before a court or governmental body seeking to restrain or
     invalidate all or any portion of any of such transaction, or seeking
     damages or other relief against Buyer or any of his or its affiliates upon
     the consummation of all or any portion of such transaction, and there shall
     not have been adopted any law or regulation making all or any portion of
     such transaction illegal.

     4.2 Conditions to Obligations of Seller.  The obligations of Seller
hereunder are subject to the satisfaction at or prior to the Closing of the
following conditions, unless waived by the Seller:

          (a)  Performance. Each of the covenants and obligations of Buyer to be
     performed at or prior to the Closing shall have been duly performed;

          (b)  Representations and Warranties.  Each representation and warranty
     of Buyer shall be true and correct as of the Closing, as if such
     representation and warranty had been made at such time and Seller shall
     have received a certificate to that effect in the form attached hereto as
     Exhibit C.


                                      -5-

<PAGE>   6


          (c)  No Litigation.  There shall no injunction or court order
     restraining consummation of the transactions contemplated hereby or any
     part thereof, and there shall be no pending or threatened action or
     proceeding by or before a court or governmental body seeking to restrain or
     invalidate all or any portion of any of such transaction, or seeking
     damages or other relief against Seller or any of his affiliates upon the
     consummation of all or any portion of such transaction, and there shall not
     have been adopted any law or regulation making all or any portion of such
     transaction illegal.

          (d)  Lock-up Letter. To the extent that the Closing hereunder shall
     have occurred prior to February 7, 1999, Seller shall have delivered a
     Lock-up Agreement (the "Lock-up"), in substantially the form attached
     hereto as Exhibit D, to Dirks & Company, Inc. and Security Capital Trading,
     Inc., as representatives of the several underwriters in connection with
     Ophidian's offering of Units consisting of shares of Common Stock and
     warrants to purchase Common Stock pursuant to that certain prospectus dated
     May 7, 1998.

5.   Survival.  The representations, warranties and covenants herein or in
any certificate or other writing delivered pursuant hereto or in connection
herewith shall survive the Closing.

6.   Notices.  Any notice or other communication under or pursuant to his
Agreement shall be in writing and may be given by any of the following methods:
(a) personal delivery; (b) telecopy transmission; (c) registered or certified
mail, postage prepaid, return receipt requested; or (d) recognized overnight
delivery service.  Notice shall be to the appropriate party at the address or
telecopier number listed on the signature page hereto (or in either case to the
address or telecopier number as shall be specified by notice given under this
Agreement).

7.   Miscellaneous.

     7.1  Successors and Assigns.  This Agreement shall be binding upon and
shall inure to the benefit of the parties and their respective successors and
assigns, provided, however, that neither this Agreement, nor any right
hereunder, may be assigned by any party without the consent of the other party
hereto.

     7.2 Entire Agreement; Amendment.  This Agreement, including the recitals
hereto, and the other instruments referred to herein embody the entire agreement
of the parties hereto with respect to the subject matter hereof and supersede
all prior agreements with respect thereto.  This Agreement may be amended, and
any provision hereof waived, but only in a writing signed by the party against
whom such amendment or waiver is sought to be enforced.


                                      -6-

<PAGE>   7


     7.3  Counterparts.  This Agreement may be executed in two or more
counterparts, all of which taken together shall constitute one and the same
instrument.

     7.4  Further Assurances.  Buyer and Seller each agree to execute and
deliver such other documents, certificates, agreements and other writings and to
such other actions as may be reasonably requested by the other party in order to
consummate or implement expeditiously the transactions contemplated by this
Agreement.

     7.5  Severability. Any term or provision of this Agreement which is invalid
or unenforceable in any jurisdiction shall, as to such jurisdiction, be
ineffective to the extent of such invalidity or enforceability without rendering
invalid or unenforceable the remaining terms and provisions of this Agreement,
or affecting the validity or enforceability of any of the terms or provisions of
this Agreement in any other jurisdiction.

     7.6  Captions. The captions herein are inserted for convenience of
reference only and shall be ignored in the construction or interpretation
hereof.

     7.7  Governing Law.  This Agreement shall be governed by and construed
under the laws of the State of Illinois without giving effect to principles of
conflict of laws.

     7.8  Termination.  This Agreement may be terminated and the transactions
contemplated hereby may be abandoned at any time prior to the Closing:

          (a)  By the mutual written consent of Buyer and Seller;

          (b)  By Buyer, by written notice to Seller on any date after March 1,
     1999 if the Closing has not taken place by such date;

          (c)  By Seller, by written notice to Buyer on any date after March 1,
     1999 if the Closing has not taken place by such date; or

          (d)  By Buyer, by written notice to Seller, at any time after a
     proceeding under any bankruptcy, reorganization, arrangement of debt,
     insolvency, readjustment of debt or receivership law is filed against
     Ophidian.

Upon any such termination, the transactions contemplated hereby shall be
abandoned without further action by any party, and neither party to this
Agreement shall have any right or claim against the other on account of such
termination unless this Agreement is terminated by a party on account of the
breach of any representation, warranty, term or covenant herein by the other
party, in which case the terminating party shall be entitled to all of its
rights and remedies at law or in equity.


                                      -7-
<PAGE>   8


     IN WITNESS WHEREOF, this Agreement has been executed by each of the parties
hereto as of the day and ate first above written.


                                                  SELLER:


                                                  /s/ SEAN B. CARROLL
                                                  -----------------------------
                                                  Sean B. Carroll
                                                  1525 Linden Drive
                                                  Madison, Wisconsin  53706
                                                  Telecopier:  608/262-9343


                                                  BUYER:



                                      -8-

<PAGE>   9


                                   EXHIBIT A

                                      
Wire Transfer Instructions


               Account Number:















                                      -1-
<PAGE>   10


                                   EXHIBIT B

                          FORM OF SELLER'S CERTIFICATE


     The undersigned hereby certifies that my representations and warranties
contained in the Purchase Agreement dated as of February __, 1999, between me
and ____________ are true and correct on and as of the date hereof.

     This Certificate is being furnished to the Buyer with the understanding
that it will be relied upon by the Buyer, as well as by Ophidian and the law
firm of LaFollette Sinykin, LLP, as counsel to Ophidian, in conjunction with its
rendering of a legal opinion to Ophidian regarding the transfer.

     IN WITNESS WHEREOF, the undersigned has executed this certificate this day
of _________ , 1999.



                                                       /s/ Sean B. Carroll
                                                       -----------------------
                                                       Sean B. Carroll


                                      -2-

<PAGE>   11


                                   EXHIBIT C

                          FORM OF BUYER'S CERTIFICATE


     The undersigned hereby certifies that the undersigned's representations and
warranties contained in the Purchase Agreement dated as of February   , 1999,
between the undersigned and Sean B. Carroll are true and correct on and as of
the date hereof.

     This Certificate is being furnished to the Seller with the understanding
that it will be relied upon by the Seller, as well as by Ophidian and the law
firm of LaFollette Sinykin, LLP, as counsel to Ophidian, in conjunction with its
rendering of a legal opinion to Ophidian regarding the transfer.


     The undersigned hereby further certifies that he or it has received or has
had access to all information necessary for the purchase of the Shares referred
to in the Purchase Agreement, he or it has been fully advised regarding the
restrictive status of the stock,and the undersigned is purchasing the Shares for
investment purposes only and with no intent of re-sale.

     IN WITNESS WHEREOF, the undersigned has executed this certificate this day
of _________ , 1999.


                                                --------------------------------



                                        
                                      -3-

<PAGE>   12


                                   EXHIBIT D

DIRKS & COMPANY, INC.
SECURITY CAPITAL TRADING, INC.,
As Representatives of the several Underwriters
520 Madison Avenue
New York, New York  10022

Ladies and Gentlemen:

     In order to induce Dirks & Company, Inc. and Security Capital Trading,
Inc., the representatives of the several underwriters (the "Representatives") to
consent to the transfer of ___ shares (the "Shares") of the Common Stock, par
value $.0025 per share ("Common Stock") of Ophidian Pharmaceuticals, Inc., a
Wisconsin corporation ("Ophidian") by Sean B. Carroll ("Carroll"),
notwithstanding the terms of that certain letter agreement executed by Carroll
in favor of the Representatives, dated as [May 7, 1998], the undersigned hereby
agrees that from the date hereof until February 7, 1999, the undersigned will
not, without the prior written consent of the Representatives, sell, contract or
offer to sell, issue, transfer, assign, pledge, distribute or otherwise dispose
of, directly or indirectly, the Shares.

     In order to enable the aforesaid covenants to be enforced, the undersigned
hereby consents to the placing of legends and/or stop-transfer orders with the
transfer agent of Ophidian's securities with respect to the Shares.

     This Agreement shall be governed by and construed and enforced in
accordance with the laws of the State of New York without giving effect to the
choice of law or conflicts of law principles.

Dated:  February __, 1999



- --------------------------------  --------------------------------
Address                           Signature


- --------------------------------  --------------------------------
Social Security Number or         Name
Taxpayer I.D. Number


                                        
                                        
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