OPHIDIAN PHARMACEUTICALS INC
DEFS14A, 2000-10-10
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                            OPHIDIAN
                      Pharmaceuticals, Inc.

                    SCHEDULE 14A INFORMATION

        Proxy Statement Pursuant to Section 14(a) of the
                 Securities Exchange Act of 1934


Filed by the Registrant                      [X]
Filed by a Party other than the Registrant   [ ]

Check the appropriate box:

[ ] Preliminary Proxy Statement    [ ] Confidential for Use of
                                   the Commission Only (as permitted
                                   by Rule 14a-6(e)(2))
[X] Definitive Proxy Statement
[ ] Definitive Additional Materials
[ ] Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                OPHIDIAN PHARMACEUTICALS, INC.
        (Name of Registrant as Specified in its Charter)
    _________________________________________________________________
 (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee  (Check the appropriate box)

[ ] No fee required.
[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
     (1)  Title of each class of securities to which transaction
          applies:__________________________________________________________

     (2)  Aggregate number of securities to which transaction
          applies:______________


     (3)  Per unit price or other underlying value of transaction
          computed pursuant to Exchange Act Rule 0-11 (set forth the amount
          on which the filing fee is calculated and state how it was
          determined):

     (4)  Proposed maximum aggregate value of transaction:

     (5)  Total fee paid:

[X] Fee paid previously with preliminary materials:  $700

<PAGE>

[ ]  Check box if any part of the fee is offset as provided by
     Exchange Act Rule 0-11(a)(2) and identify the filing for
     which the offsetting fee was paid previously.  Identify the
     previous filing by registration statement number, or the
     form or schedule and the date of its filing.
     (1)  Amount previously paid:_______________________________
     (2)  Form, Schedule or Registration Statement No.:______________________
     (3)  Filing Party:  ________________________________________
     (4)  Date Filed:  __________________________________________

<PAGE>

           [Ophidian Pharmaceuticals, Inc. Letterhead]

                    5445 East Cheryl Parkway
                       Madison, WI   53711

Dear Ophidian Stockholder:

As you may know, Ophidian closed down its operations this May for
lack of adequate financing.  For several months, the Company's
management and Board of Directors have diligently sought
proposals for a merger and/or an asset sale transaction from a
number of parties and considered a variety of possible
transactions.  As described in detail in the accompanying Notice
of Special Meeting and attached Proxy Statement, the Board of
Directors is seeking your consideration of, and strongly urging
you to vote "FOR", the following two proposals, which are the
culmination of that search:  (1) to sell substantially all of the
Company's assets to Promega Corporation, (the "Asset Sale") and
(2) to authorize the Board of Directors to dissolve the Company,
wind down its affairs, and effect the proposed Plan of
Dissolution and Liquidation (the "Plan of Dissolution").

All of the members of the Board of Directors are firmly committed
to the proposed Asset Sale and Plan of Dissolution, both of which
were unanimously approved by the Board after careful
consideration.  We strongly believe that there is no better
alternative currently available to preserve the Company's
remaining cash and, more importantly, to maximize value for
Ophidian's stockholders and creditors.  We also believe that
failure to approve the proposed Asset Sale and Plan of
Dissolution, will, in all likelihood, increase costs to the
Company and reduce or eliminate the amount of any possible
distribution to stockholders.

Your vote on each of these matters is very important.  Under
Delaware law, the proposed Asset Sale and Plan of Dissolution
cannot be completed unless the holders of at least a majority of
the outstanding shares of the Company's Common Stock vote in
favor of each proposal.  All unreturned proxies and abstentions
will have the same effect as votes against the two proposals.
Therefore, and whether or not you plan to attend the Special
Meeting, please take the time to vote and return the enclosed
proxy card in the accompanying postage-paid envelope.  The Board
of Directors unanimously and strongly urges you to vote "FOR"
both proposals, and we encourage you to read the entire Proxy
Statement.

Your participation is extremely important.  Your early response
will be greatly appreciated and will allow us to effect the
proposals at the lowest possible cost to you and the Company.

                         Sincerely,

                         /s/ Margaret van Boldrik

                         Margaret van Boldrik
                         Director and Vice President

<PAGE>

            NOTICE OF SPECIAL MEETING OF STOCKHOLDERS

            TO BE HELD ON THURSDAY, NOVEMBER 9, 2000

TO THE STOCKHOLDERS:

     Notice is hereby given that a Special Meeting of
Stockholders of Ophidian Pharmaceuticals, Inc., a Delaware
corporation (the "Company" or "Ophidian"), will be held on
Thursday, November 9, 2000, at 10:00 a.m., central standard time,
in the auditorium of the BioPharmaceutical Technology Center at
5445 East Cheryl Parkway, Madison, Wisconsin 53711, for the
following purposes:

  1. to consider and vote upon the proposed sale of
     substantially all of the Company's assets (the "Asset
     Sale") to Promega Corporation, a Wisconsin corporation
     ("Promega") pursuant to the terms of the Asset Purchase
     Agreement dated as of September 1, 2000, by and between
     the Company as seller and Promega as buyer (the "Purchase
     Agreement"), a copy of which is attached to the
     accompanying Proxy Statement as Exhibit A; and

  2. to consider and vote upon the proposed authorization to
     the Company's Board of Directors to effect the
     dissolution and liquidation of the Company as described
     in the proposed Plan of Dissolution and Liquidation (the
     "Plan of Dissolution"), a copy of which is attached to
     the accompanying Proxy Statement as Exhibit B; and

to transact such other business as may properly come before
the meeting or any postponements or adjournments thereof.

The foregoing items of business are more fully described in the
Proxy Statement accompanying this Notice.  Pursuant to the
Company's bylaws, the Board of Directors has fixed the close of
business on September 29, 2000, as the record date for the
determination of stockholders entitled to notice of and to vote
at the meeting (the "Record Date").  Only stockholders of record
at that time will be entitled to vote at the meeting or any
postponement or adjournment thereof.

All stockholders are cordially invited to attend the meeting in
person.  However, to assure your representation at the meeting,
you are urged to mark, sign, date, and return the enclosed proxy
as promptly as possible in the postage-prepaid envelope  enclosed
for that purpose.  Any stockholder attending the meeting may vote
in person even if such stockholder previously signed and returned
a proxy.

                              By Order of the Board of Directors,

                              /s/ Susan P. Maynard

Madison, Wisconsin            Susan P. Maynard
September 29, 2000            Secretary

<PAGE>

        Ophidian Pharmaceuticals, Inc.  - Proxy Statement

                        Table of Contents

PROXY STATEMENT FOR SPECIAL MEETING OF STOCKHOLDERS                          1

SUMMARY TERM SHEETS                                                          1

 THE ASSET SALE                                                              1
 THE DISSOLUTION AND PLAN OF DISSOLUTION AND LIQUIDATION                     3

INFORMATION CONCERNING SOLICITATION, REVOCATION, AND VOTING OF PROXIES       6

   RECORD DATE AND SHARES OUTSTANDING                                        6
   VOTING, QUORUM; ABSTENTIONS; AND BROKER NON-VOTES                         6
   PROXY SOLICITATION                                                        6
   VOTING AND REVOCABILITY OF PROXIES                                        6
   ADJOURNMENTS                                                              7

INFORMATION ABOUT FORWARD-LOOKING STATEMENTS                                 7

RISK FACTORS RELATING TO THE ASSET SALE AND THE PLAN OF DISSOLUTION          8

   ESTIMATES OF THE NET PROCEEDS FROM THE ASSET SALE AND DISTRIBUTIONS
   TO BE RECEIVED BY STOCKHOLDERS MAY NOT BE REALIZED                        8
   THE COMPANY WOULD INCUR COSTS IF THE PURCHASE AGREEMENT WERE
   TERMINATED BECAUSE OF THE RECEIPT BY THE COMPANY OF A
   SUPERIOR PROPOSAL                                                         9
   THE ASSET SALE MAY NOT BE CONSUMMATED                                     9
   ANTICIPATED TIMING OF PLAN OF DISSOLUTION MAY NOT BE ACHIEVED             9
   THERE CAN BE NO ASSURANCE THAT THE ASSET SALE AND THE PLAN OF
   DISSOLUTION WILL RESULT IN GREATER RETURNS TO STOCKHOLDERS
   THAN A CONTINUATION OF THE COMPANY AS CURRENTLY OPERATED                  9
   THE BOARD MAY AMEND, DELAY IMPLEMENTATION OF, OR TERMINATE
   THE PLAN OF DISSOLUTION EVEN IF IT IS APPROVED BY THE STOCKHOLDERS       10
   STOCKHOLDERS COULD BE LIABLE TO THE EXTENT OF ANY
   DISTRIBUTIONS TO THEM IF CONTINGENT RESERVES ARE INSUFFICIENT
   TO SATISFY THE COMPANY'S LIABILITIES                                     10

PROPOSAL ONE - TO APPROVE THE ASSET SALE                                    11

 DESCRIPTION OF THE ASSET SALE                                              11

   GENERAL OVERVIEW                                                         11
   BACKGROUND AND HISTORY OF THE ASSET SALE                                 11
   BUYER                                                                    12
   PURCHASE PRICE                                                           12
   EXPECTED PROCEEDS OF THE ASSET SALE                                      13
   EXPECTED TIMING OF THE ASSET SALE                                        13
   REPRESENTATIONS AND WARRANTIES; CLOSING CONDITIONS                       13
   INDEMNIFICATION BY SELLER                                                14
   TERMINATION OF THE PURCHASE AGREEMENT                                    14
   GOVERNMENT APPROVALS                                                     15
   NO APPRAISAL RIGHTS                                                      15
   ACCOUNTING TREATMENT OF THE ASSET SALE                                   15
   FEDERAL INCOME TAX CONSEQUENCES OF THE ASSET SALE                        15

<PAGE>

   PRICE RANGE OF COMMON STOCK AND WARRANTS                                 16
   INTEREST OF CERTAIN PERSONS IN MATTERS TO BE ACTED UPON                  16
   VOTE REQUIRED                                                            17
   RECOMMENDATION OF THE BOARD                                              17

PROPOSAL TWO - APPROVAL OF THE DISSOLUTION                                  17

 PROPOSED STOCKHOLDER ACTION                                                17
 DESCRIPTION OF THE PLAN OF DISSOLUTION                                     17

   BACKGROUND AND REASONS FOR THE DISSOLUTION                               18
   RISK FACTORS                                                             18
   DISSOLUTION AND LIQUIDATION PROCEDURE                                    18
   ABANDONMENT OF THE PLAN OF DISSOLUTION                                   18
   CONDUCT OF THE COMPANY FOLLOWING DISSOLUTION                             19
   SALE OF REMAINING ASSETS                                                 19
   PAYMENT OF CLAIMS AND OBLIGATIONS.                                       19
   DISTRIBUTIONS TO STOCKHOLDERS                                            20
   LIQUIDATION TRUST                                                        21
   DELISTING AND TRADING OF THE COMMON STOCK AFTER DISSOLUTION              21
   CONTINUING LIABILITY OF STOCKHOLDERS AFTER DISSOLUTION                   21
   NO APPRAISAL RIGHTS                                                      22
   REGULATORY MATTERS                                                       22

 CERTAIN FEDERAL INCOME TAX CONSEQUENCES                                    22

   GENERAL                                                                  22
   CONSEQUENCES TO THE COMPANY                                              23
   CONSEQUENCES TO STOCKHOLDERS                                             23

 VOTE REQUIRED                                                              24
 RECOMMENDATION OF THE BOARD                                                24

OTHER MATTERS                                                               24

OTHER INFORMATION REGARDING THE COMPANY                                     24

 VOTING SECURITIES AND PRINCIPAL HOLDERS THEREOF                            24
 CHANGES IN CONTROL                                                         26
 SELECTED FINANCIAL DATA, INCLUDING PRO FORMA INFORMATION                   26
 NOTES TO PRO FORMA FINANCIAL STATEMENTS                                    29
 STOCKHOLDER PROPOSALS                                                      30
 WHERE YOU CAN FIND MORE INFORMATION                                        30
 INFORMATION INCORPORATED BY REFERENCE                                      31

SIGNATURE                                                                   32

<PAGE>
                            OPHIDIAN
                      Pharmaceuticals, Inc.


       PROXY STATEMENT FOR SPECIAL MEETING OF STOCKHOLDERS


The enclosed Proxy is solicited on behalf of the Board of
Directors of Ophidian Pharmaceuticals, Inc. (the "Company" or
"Ophidian") for use in connection with a Special Meeting of the
Stockholders (the "Special Meeting") to be held Thursday,
November 9, 2000, at 10:00 a.m., central standard time, or at any
adjournments or postponements of the Special Meeting.  The
Special Meeting will be held in the auditorium of the
BioPharmaceutical Technology Center at 5445 East Cheryl Parkway,
Madison, Wisconsin 53711.  The Company's principal executive
offices are also located at this site.  The Company's telephone
number is (608) 271-0878.  These proxy solicitation materials
were mailed on or about October 10, 2000, to all stockholders
entitled to vote at the Special Meeting.

                       SUMMARY TERM SHEETS

The following summary terms sheet highlight selected information
from this Proxy Statement and may not contain all of the
information that is important to every stockholder.  To
understand the transactions fully and for a more complete
description of the legal terms of the transactions, stockholders
should read carefully this entire Proxy Statement and the
attached documents.

                         The Asset Sale

Note, a copy of the "Asset Purchase Agreement" (referred to
hereafter as the "Purchase Agreement") is attached to this Proxy
Statement as Exhibit A.

The Parties to the Asset Sale

   Ophidian Pharmaceuticals, Inc.     Ophidian, a development stage
   5445 East Cheryl Parkway           corporation, was founded in 1989
   Madison, WI  53711                 to discover, develop, and
   (608) 271-0878                     commercialize therapeutic products
                                      for human and animal use with a
                                      principal focus on products for
                                      infectious disease prevention and
                                      treatment.  See "Where You Can
                                      Find More Information."

   Promega Corporation                Founded in 1978, Promega provides
   2800 Woods Hollow Road             products and technical support for
   Madison, WI  53711-5399            the life sciences industry
   (608) 274-4330                     worldwide and has annual sales in
                                      excess of  $100 million.

<PAGE>

The Purchase Agreement & Price        At closing Promega will pay
                                      Ophidian $1.25 million in cash,
                                      and deliver a promissory note for
                                      an additional $250,000, payable
                                      within 90 days of closing, subject
                                      to offset for any post-closing
                                      adjustments.  Promega will also
                                      assume Ophidian's obligations
                                      under (a) two senior secured notes
                                      in the total original principal
                                      amount of $2 million and (b) the
                                      Company's office/lab and
                                      manufacturing leases.  In
                                      exchange, Ophidian will transfer
                                      to Promega substantially all of
                                      its assets.

Anticipated Closing of the Asset Sale On the second business day after
                                      Ophidian satisfies, or Promega
                                      waives, all the conditions
                                      precedent to Promega's obligation
                                      to close, but not later than
                                      November 30, 2000.

Conditions to Closing                 The Purchase Agreement contains
                                      conditions to closing, including:
                                      (a) approval by a majority of
                                      Ophidian's stockholders and (b)
                                      other conditions customary for
                                      transactions of this type.  See
                                      "Proposal One-Representations and
                                      Warranties; Closing Conditions".

Indemnification                       Ophidian has agreed to indemnify
                                      Promega for any losses and
                                      expenses resulting from any
                                      inaccuracy, breach, or default of
                                      Ophidian's representations,
                                      warranties, covenants,
                                      obligations, or agreements in the
                                      Purchase Agreement, or Ophidian's
                                      use of its assets prior to
                                      closing.  The amount of the
                                      indemnification is limited to
                                      $250,000, which may be offset
                                      against Promega's purchase price
                                      promissory note in the same amount.

Termination                           The Purchase Agreement may be
                                      terminated prior to closing as
                                      follows:
                                      *    by Promega if the closing has
                                           not occurred by November 30, 2000;
                                      *    by Promega during the first
                                           45 days based upon Promega's due
                                           diligence investigation;
                                      *    by either party if the other
                                           party is in breach;
                                      *    by Ophidian if it has
                                           received a "Superior Proposal,
                                           complied with the notice
                                           provisions to Promega in the
                                           Purchase Agreement and paid
                                           Promega a "Termination Fee" of
                                           $100,000; and
                                      *    by mutual consent of the parties.
                                      See "Proposal One - Termination of
                                      the Purchase

<PAGE>

                                      Agreement".

Government Approvals                  No federal or state regulatory
                                      requirements or approvals are
                                      required for the Asset Sale other
                                      than compliance with applicable
                                      state corporate law and federal
                                      and state securities laws.

Appraisal Rights                      Stockholders will have no
                                      appraisal rights in connection
                                      with the Asset Sale.

Accounting Treatment                  The Asset Sale will be treated as
                                      a sale of assets and liabilities
                                      for accounting purposes.

Federal Income Tax Consequences       The Asset Sale will not result in
                                      any federal income tax
                                      consequences to the stockholders,
                                      but the sale will be a taxable
                                      transaction to Ophidian.  However,
                                      Ophidian does not expect to incur
                                      any significant federal income tax
                                      liability because of its net
                                      operating loss carry-forwards
                                      available to offset any gain on
                                      the Asset Sale.

     The Dissolution and Plan of Dissolution and Liquidation

Note, the "Plan of Dissolution and Liquidation" (hereafter, the
"Plan" or "Plan of Dissolution") is attached, in its entirety, to
this Proxy Statement as Exhibit B.

Timing & Procedure                    Upon approval by the stockholders
                                      and completion of the Asset Sale,
                                      if completed by November 30, 2000,
                                      Ophidian will file a Certificate
                                      of Dissolution with the Secretary
                                      of State for Delaware and the
                                      Company will thereafter take steps
                                      to wind up its affairs, including
                                      liquidation of any remaining
                                      assets and payment of outstanding
                                      claims, at such times as the Board
                                      of Directors deems necessary,
                                      appropriate, or advisable.  The
                                      Board of Directors may delay the
                                      dissolution upon completion of the
                                      Asset Sale or an alternative asset sale.

Abandonment of the Plan               The Board of Directors may abandon
                                      the Plan entirely without further
                                      stockholder action if it
                                      determines that dissolution and
                                      liquidation are not in the best
                                      interests of the stockholders.

Post-Dissolution Conduct of Ophidian  Under Delaware law, after
                                      dissolution Ophidian will continue
                                      to exist for three years solely
                                      for the purpose of winding up its
                                      affairs.  During this time

<PAGE>

                                      the Company's Board of Directors and
                                      officers will oversee the
                                      liquidation of the Company's
                                      assets, but will not continue its
                                      business.  They will:
                                      *    settle and close the
                                           Company's business;
                                      *    convert to cash, by sales, as
                                           much of the Company' non-cash
                                           assets as possible;
                                      *    withdraw from any
                                           jurisdiction where the Company is
                                           qualified to do business;
                                      *    pay or make provision to pay
                                           the Company's expenses and other
                                           liabilities;
                                      *    prosecute and defend any lawsuits;
                                      *    distribute the Company's
                                           remaining assets to the
                                           stockholders;
                                      *    do any other act necessary to
                                           wind up and liquidate the
                                           Company's business and affairs.
                                      See "Proposal Two-Conduct of the
                                      Company Following Dissolution."

Sale of Remaining Assets              Although the Board of Directors is
                                      seeking separate approval at the
                                      Special Meeting for the Asset
                                      Sale, if the Plan of Dissolution
                                      is approved by the stockholders,
                                      the Board of Directors will be
                                      authorized to sell all of the
                                      Company's assets in alternative
                                      transactions after the Company's
                                      dissolution and without further
                                      stockholder action or approval
                                      even if the stockholders fail to
                                      approve the Asset Sale or the
                                      Asset Sale is not completed as
                                      contemplated.  See "Proposal Two-
                                      Sale of Remaining Assets."

Payment of Claims & Obligations       Before distributing any assets to
                                      stockholders, the Company will pay
                                      and discharge, or make provisions
                                      reasonably likely to provide
                                      sufficient compensation for all
                                      claims and obligations of the
                                      Company, including claims that are
                                      contingent, conditional, or
                                      unmatured, pending, or that have
                                      not arisen but are likely to arise
                                      within ten years after the
                                      Company's dissolution.  See
                                      "Proposal Two-Payment of Claims
                                      and Obligations."

Distributions to Stockholders         Once adequate provisions have been
                                      made for payment of all the
                                      Company's claims and obligations,
                                      all of the Company's remaining
                                      assets will be distributed to
                                      stockholders in one or more
                                      distributions.  Uncertainties as
                                      to the net value of the assets and
                                      the ultimate amount of the

<PAGE>

                                      Company's liabilities make it
                                      impossible to predict with
                                      certainty the amount that will be
                                      distributed to stockholders, but
                                      the Company currently estimates
                                      that it will distribute
                                      approximately $1.00 per share in a
                                      single distribution in the first
                                      quarter of calendar year 2001.
                                      See "Proposal Two -Distributions
                                      to Stockholders."

Liquidating Trust                     The Board of Directors may, in its
                                      absolute discretion, transfer the
                                      Company's assets to a liquidating
                                      trust after dissolution.  See
                                      "Proposal Two-Liquidating Trust."

Delisting of the Common Stock         After dissolution, the Board of
                                      Directors will determine when to
                                      delist the Common Stock and the
                                      warrants from the NASDAQ SmallCap
                                      System and Pacific Exchange.

Continuing Liability of Stockholders  Under Delaware law, a
                                      stockholder's maximum liability
                                      for any claim against the Company
                                      that has not been paid or
                                      otherwise provided for will not
                                      exceed the amount actually
                                      distributed to the stockholder in
                                      dissolution.  See "Proposal Two-
                                      Continuing Liability of
                                      Stockholders After Dissolution."

Appraisal Rights                      Under Delaware law, stockholders
                                      are not entitled to appraisal
                                      rights in connection with the
                                      dissolution and Plan of
                                      Dissolution.

Regulatory Matters                    Following stockholder approval,
                                      the Company is not subject to any
                                      federal or state regulatory
                                      requirements in dissolving the
                                      Company other than the requirement
                                      to file a Certificate of Dissolution.

Federal Income Tax Consequences       Until the winding up and
                                      liquidation of the Company is
                                      completed, the Company will remain
                                      subject to income tax on its
                                      taxable income.  Each stockholder
                                      will recognize a capital gain or loss
                                      equal to the difference between
                                      the amount distributed to them and
                                      their adjusted tax basis in the
                                      their shares.  See "Proposal Two-
                                      Certain Federal Income Tax Consequences.

<PAGE>

              INFORMATION CONCERNING SOLICITATION,
                REVOCATION, AND VOTING OF PROXIES

RECORD DATE AND SHARES OUTSTANDING

Stockholders of record at the close of business on September 29,
2000 (the "Record Date"), are entitled to notice of, and to vote
at, the Special Meeting.  At the Record Date, of the 22,400,000
authorized shares of the Company's common stock, $0.0025 par
value per share (the "Common Stock"), 1,158,249 shares of such
Common Stock were issued, outstanding, and entitled to vote at
the Special Meeting.

VOTING, QUORUM; ABSTENTIONS; AND BROKER NON-VOTES

Every stockholder of record on the Record Date is entitled, for
each share of Common Stock held, to one vote for or against each
matter presented at the Special Meeting .  The required quorum
for the transaction of business at the Special Meeting is a
majority of the shares outstanding on the Record Date.  Broker
non-votes and shares held by persons abstaining and any other
shares represented for any purpose, other than objecting to
holding the meeting or transacting business at the meeting, will
be counted in determining whether a quorum is present.  Under
Delaware law, the affirmative vote of at least a majority of the
outstanding shares of Common Stock is required for approval of
both the Asset Sale and the authorization to dissolve the Company
and liquidate its assets pursuant to the Plan of Dissolution.
Because the affirmative vote of at least a majority of all
outstanding shares of Common Stock is required for approval of
both proposals, broker non-votes, abstentions, and shares as to
which proxy authority has been withheld all will have the same
effect as votes against the two proposals.

PROXY SOLICITATION

The enclosed proxy is being solicited by the Company's Board of
Directors, and the cost of this solicitation will be borne by the
Company.  The Company may reimburse expenses incurred by
brokerage firms and other persons representing beneficial owners
of shares in forwarding solicitation material to the beneficial
owners.  The Company has selected Continental Stock Transfer &
Trust Company, its transfer agent, and may also retain a
professional proxy solicitation firm, to assist it and its
stockholders in connection with the Special Meeting.  Proxies may
also be solicited by certain of the Company's directors,
officers, and regular employees, without additional compensation,
personally, by telephone, facsimile, e-mail, or telegram.

VOTING AND REVOCABILITY OF PROXIES

When proxies are properly executed, dated, and returned, the
shares they represent will be voted at the Special Meeting in
accordance with the instructions of the stockholders.  If no
specific instructions are given, the shares will be voted (a)
"FOR" the approval of the Asset Sale; (b) "FOR" the authorization
to dissolve the Company and liquidate its assets pursuant to the
Plan of Dissolution; and (c) in the discretion of the proxy
holders, upon such other matters not know known or determined
which may properly come before the Special Meeting.  Any proxy
given pursuant to this solicitation may be revoked by the person
giving it at any time before it is voted

<PAGE>

by (a) delivering a written notice to the Secretary of the
Company or the acting secretary of the Special Meeting; or (b)
giving oral notice to the presiding officer during the Special
Meeting; or (c) duly executing a proxy bearing a later date; or
(d) attending the Special Meeting and voting in person.  The mere
presence at the Special Meeting of a stockholder who has filed a
proxy will not constitute a revocation.

ADJOURNMENTS

In the event that sufficient votes in favor of the proposals set
forth in the Notice of Special Meeting of Stockholders are not
received by the date of the Special Meeting, the Board of
Directors may propose one or more adjournments of the Special
Meeting for a period or periods of not more than 45 days in the
aggregate to permit further solicitation of proxies, even though
a quorum is present.  Any such adjournment will require the
affirmative vote of a majority of the votes cast on the question
in person or by proxy at the session of the Special Meeting to be
adjourned.  The proxy holders will vote the shares they represent
by proxy in favor of such adjournment.  The costs of any such
additional solicitation and of any adjourned session will be
borne by the Company.

          INFORMATION ABOUT FORWARD-LOOKING STATEMENTS

Certain sections of this Proxy Statement contain forward-looking
statements that are based on current beliefs, estimates and
assumptions concerning the operations and future results of the
Company, the Asset Sale, the Plan of Dissolution, estimated costs
and expenses, the amount of cash expected to be distributed to
stockholders and the timing of such distributions. All statements
that address events or developments that are anticipated to occur
in the future, including statements related to future revenues,
expenses, income, earnings per share, and anticipated
distributions, or statements expressing general optimism about
future results, are forward-looking statements.  In addition,
words such as "expects," "anticipates," "intends," "plans,"
"believes," "estimates," and variations of such words and similar
expressions are intended to identify forward-looking statements.

The statements described in the preceding paragraph, and the
sections of this Proxy Statement referred to therein, constitute
"forward-looking statements" within the meaning of Section 21E of
the Securities Exchange Act of 1934, as amended (the "Exchange
Act").  Because these statements are based on a number of
beliefs, estimates, and assumptions that could cause actual
results to materially differ from those in the forward-looking
statements, there can be no assurance that the forward-looking
statements will prove to be accurate.

Any number of factors could affect the Company's operations and
future results and the amount and timing of cash expected to be
distributed to stockholders, including the actions of third
parties (including the other parties to the Asset Sale), the
timely consummation of the Asset Sale, the timing and method of
implementation of the Plan of Dissolution, general industry and
economic conditions, changes in applicable laws, rules and
regulations (including changes in tax laws) and those specific
risks that are discussed in the Risk Factors detailed herein and
in the Company's previous filings with the Securities and
Exchange Commission.

<PAGE>

Readers are cautioned not to place undue reliance on these
forward-looking statements, which speak only as of the date of
this Proxy Statement.  The Company undertakes no obligation to
update any forward-looking statements, whether as a result of new
information or future events.

             RISK FACTORS RELATING TO THE ASSET SALE
                   AND THE PLAN OF DISSOLUTION

In addition to the other information included elsewhere in this
Proxy Statement, the following factors should be considered
carefully in determining whether to vote in favor of the
proposals to approve the Asset Sale and the Plan of Dissolution.

ESTIMATES OF THE NET PROCEEDS FROM THE ASSET SALE AND
DISTRIBUTIONS TO BE RECEIVED BY STOCKHOLDERS MAY NOT BE REALIZED

There can be no assurance that the Asset Sale will be consummated
or that any of the estimates set forth in this Proxy Statement
will be realized.  Stockholders, in determining whether to vote
in favor of the proposals to approve the Asset Sale and the Plan
of Dissolution, are cautioned not to attribute undue certainty to
any estimates set forth herein.  Such estimates are based on a
variety of assumptions relating to the likelihood of closing the
Asset Sale, the value of the Company's other remaining assets,
the amount of the Company's liabilities and expenses to be paid
in the future, general business and economic conditions, and
other matters.  The amount of proceeds from the Asset Sale and
the amount to be distributed to stockholders are based on the
Company's current estimates and are subject to various and
significant uncertainties, many of which are beyond the Company's
control, that could cause the actual results to differ materially
from the Company's expectations.  See "Proposal Two -
Distributions to Stockholders" below.  Examples of uncertainties
that could cause the amount of proceeds from the Asset Sale and
distributions to stockholders to be less than the Company's
estimates include the following:

     * The Company's estimates of net proceeds from the Asset Sale
       and the amount of the initial cash distribution are based on
       estimates of the costs and expenses of the Asset Sale and the
       dissolution.  If actual costs and expenses exceed the Company's
       estimates, actual net proceeds and distributions to stockholders
       could be less than estimated.

     * If liabilities of the Company that are unknown or contingent
       at the time of the mailing of this Proxy Statement later arise or
       become fixed in amount and must be satisfied or reserved for as
       part of the dissolution, the amount of distributions to
       stockholders could be reduced.

     * Termination of the Asset Sale or delays in consummating the
       Asset Sale or the Plan of Dissolution, such as delays in the
       closing of the Purchase Agreement, could result in additional
       expenses and result in lower actual distributions to stockholders
       than the amounts estimated by the Company.  See "The Asset Sale
       May Not Be Consummated" and "Anticipated Timing of the Plan of
       Dissolution May Not be Achieved" below.

<PAGE>

For the foregoing reasons, the actual distributions to
stockholders could vary materially from the Company's estimate
and may be substantially less.  See "Information About Forward-
Looking Statements" above.

THE COMPANY WOULD INCUR COSTS IF THE PURCHASE AGREEMENT WERE
TERMINATED BECAUSE OF THE RECEIPT BY THE COMPANY OF A SUPERIOR
PROPOSAL

If the Company terminates the Purchase Agreement because it has
received a "Superior Proposal" (as defined in the Purchase
Agreement), the Company is obligated under the Purchase Agreement
to (a) pay Promega a termination fee of $100,000 and (b)
reimburse Promega for all out-of-pocket fees and expenses
incurred by or on behalf of Promega in connection with the
Purchase Agreement, including all reasonable fees of counsel,
accountants, and consultants.  In addition, the Company has
incurred, and expects to continue to incur, substantial costs on
its own behalf in connection with the Asset Sale.

THE ASSET SALE MAY NOT BE CONSUMMATED

The consummation of the Asset Sale is subject to numerous
conditions.  Even if the stockholders vote to approve the Asset
Sale, there can be no assurance, that the Asset Sale will be
consummated.  If the Asset Sale is not consummated, the Company
may not be able to sell its assets on terms as favorable as those
provided in the Purchase Agreement, which would mean that less
cash would be available for distribution to stockholders than if
the Asset Sale had been consummated.

ANTICIPATED TIMING OF PLAN OF DISSOLUTION MAY NOT BE ACHIEVED

Even if the stockholders vote to approve the Plan of Dissolution,
the Board has reserved the right, in its sole discretion, to
amend, delay implementation of, or terminate the Plan of
Dissolution unless it determines that such action would
materially and adversely affect the stockholders' interests.
Although the board of directors presently intends to dissolve the
Company and implement the Plan of Dissolution as soon as
practicable after the consummation of the Asset Sale, the
occurrence of certain contingencies may require the board of
directors to delay the Company's dissolution.  For example, the
filing of any stockholder litigation or additional claims by
creditors may require the Company to delay its dissolution.  Any
such delay would likely increase the Company's costs and reduce
the amount available for distribution to stockholders.

THERE CAN BE NO ASSURANCE THAT THE ASSET SALE AND THE PLAN OF
DISSOLUTION WILL RESULT IN GREATER RETURNS TO STOCKHOLDERS THAN A
CONTINUATION OF THE COMPANY AS CURRENTLY OPERATED

If the Asset Sale and the Plan of Dissolution are not approved,
the Board intends to continue to manage the Company and its
assets substantially as they are currently being managed and may
entertain and consider indications of interest from third parties
to acquire the Company or all or a portion of its assets.  There
can be no assurance that the Asset Sale and Plan of Dissolution
will result in greater returns to the stockholders than a
continuation of the Company as described

<PAGE>

above.  Because the purchase price for the Company's assets under
the Purchase Agreement is fixed, the Company will not be able to
realize the benefits from any improvements in economic and market
conditions that would increase the market value of the Company's assets.

THE BOARD MAY AMEND, DELAY IMPLEMENTATION OF, OR TERMINATE THE
PLAN OF DISSOLUTION EVEN IF IT IS APPROVED BY THE STOCKHOLDERS

Even if the stockholders vote to approve the Plan of Dissolution,
the Board has reserved the right, in its sole discretion, to
amend, delay implementation of, or terminate the Dissolution Plan
unless it determines that such action would materially and
adversely affect the stockholders' interests.

STOCKHOLDERS COULD BE LIABLE TO THE EXTENT OF ANY DISTRIBUTIONS
TO THEM IF CONTINGENT RESERVES ARE INSUFFICIENT TO SATISFY THE
COMPANY'S LIABILITIES

Pursuant to the terms of the Plan of Dissolution, the Company
will pay its expenses and fixed or other known liabilities, and,
if and to the extent deemed necessary, appropriate, or desirable
by the Board of Directors, in its absolute discretion, the
Company may set aside assets in a contingency reserve for payment
of any remaining liabilities.  There can be no assurance,
however, that the contingency reserve will, in fact, be
sufficient.  Under Delaware law, if the Company (or a liquidating
trust to which the Company's assets are transferred under the
Plan of Dissolution) has inadequate reserves for payment of the
Company's expenses, obligations, and liabilities, each
stockholder could be held personally liable for his or her pro
rata share of any additional amounts owed creditors, but only to
the extent of total distributions received by each stockholder.

In addition, if a court holds at any time that the Company has
failed to make adequate provision for its obligations and
liabilities or if the amount ultimately required to be paid in
respect of such liabilities exceeds the amount available from the
contingency reserves and the assets of the liquidating trust, a
creditor of the Company could seek an injunction against the
making of distributions under the Plan of Dissolution on the
grounds that the amounts to be distributed are needed to provide
for the payment of the Company's expenses and liabilities. Any
such action could delay or substantially diminish the cash
distributions to be made to stockholders and/or holders of
beneficial interests of the liquidating trust under the Plan of
Dissolution.

<PAGE>

            PROPOSAL ONE - TO APPROVE THE ASSET SALE

                  Description of the Asset Sale

GENERAL OVERVIEW

This Proxy Statement contains a brief summary of the material
aspects of the Asset Sale and of the Purchase Agreement.  This
summary is qualified in all respects by the text of the Purchase
Agreement, a copy of which is attached to this Proxy Statement as
Exhibit A.  Stockholders are advised to read the entire Purchase
Agreement.

As described in detail in the Purchase Agreement, the Asset Sale
provides for the sale to Promega of the following assets of the
Company (the "Purchased Assets"):

     * all of the Company's intellectual property, including all
       licenses and sublicenses granted or obtained with respect
       thereto;
     * all of the Company's real estate assets, including all
       leaseholds, subleaseholds, security deposits, improvements,
       construction in progress, fixtures, and appurtenances thereto;
     * all of the Company's equipment, including all laboratory,
       farm, building, and office equipment, machinery, parts, furniture
       (except free-standing office filing cabinets), appliances,
       laboratory computers and printers (excluding office computer
       equipment), and laboratory and office supplies;
     * all of the Company's rights with respect to its contracts; and
     * all of the Company's rights with respect to any governmental
       permits, filings, qualifications, registrations, licenses,
       privileges, franchises, authorizations, and approvals.

Under the Purchase Agreement, the Company will retain any cash on
hand at the time the Asset Sale is completed, subject to certain
contingent adjustments and pro-rations described below.

BACKGROUND AND HISTORY OF THE ASSET SALE

In 1999 the Company began Phase II Clinical Testing for its lead
drug candidate for Clostridium difficile-associated disease and
undertook construction of a pilot manufacturing facility capable
of producing sufficient quantities of proprietary antibody,
drugs, and other products for the Company's clinical and
commercial use.  As previously announced, the rate of patient
enrollment in the clinical testing was slower than previously
anticipated.  In the following months, the Company has actively
sought a merger or development partner that would provide the
Company with sufficient operating capital, product development
capabilities, and marketing resources.  The Company has been
unsuccessful in acquiring such a partner.

On May 19, 2000, the Company announced that its Board of
Directors had concluded that new financing required to continue
the clinical trials and bring the nearly-completed manufacturing
facility to profitability was unlikely to be obtained prior to
the exhaustion of the Company's remaining cash reserves and that
the Company was evaluating options to conserve those reserves

<PAGE>

by reducing expenses by curtailing or discontinuing various
activities, including product development, clinical trials, and
prototype manufacturing.

On May 26, 2000, the Company announced that it was suspending
laboratory, product development, and related operations of the
Company, and was focusing on finding a merger partner,
development partner, or one or more purchasers for the Company's
intellectual property and manufacturing assets.  The Company's
work force was reduced initially by 18 full time employees.
Since this reduction in force, the Company's operations have
focused on finding a merger partner, development partner, or one
or more purchasers for the Company's assets.  The Company has
engaged numerous parties in discussions regarding such
transactions.

Promega was one of these parties, and in May it made an offer to
purchase substantially all of the Company's assets.  Following
the Company's further review of other potential merger partners
and/or buyers for the Company's assets and additional
negotiations between the Company and Promega, the Asset Sale to
Promega was approved by the Board of Directors, and the Purchase
Agreement was executed by the parties on September 1, 2000, and
subject to stockholder approval and other contingencies as set
forth in the Purchase Agreement.

BUYER

The buyer is Promega Corporation, a privately held Wisconsin
corporation, whose principal offices are located at 2800 Woods
Hollow Road, Madison, WI  53711-5399.  Promega provides products
and technical support services in the life sciences industry,
including genomic research, molecular and cell biology, molecular
diagnostics, drug discovery, and human identification.  Promega
was founded in 1978, and its annual sales exceed $100 million.

Promega owns 32,813 shares or 2.8% of the Company's outstanding
Common Stock.  In addition, Promega's Chairman, President, and
Chief Executive Officer, William A. Linton, is a former Chairman
and director of the Company and beneficial owner of 64,125 shares
or 5.5% of the Company's outstanding Common Stock, of which
32,813 shares are those owned by Promega over which Mr. Linton
may be deemed to have voting and investment power.  See "Interest
of Certain Persons in Matters to be Acted Upon," below, for a
further discussion of the current and former relationships
between Promega, Mr. Linton, and the Company.

PURCHASE PRICE

The purchase price to be paid by Promega to the Company pursuant
to the Purchase Agreement is $3,500,000, payable at the closing
of the Asset Sale as follows:

     * the assumption by Promega of two senior secured notes of the
       Company, which together have an original principal balance of
       $2,000,000;

     * the delivery of a promissory note from Promega to the
       Company in the amount of $250,000, payable in a single
       installment ninety days after closing and subject to any offset
       for indemnifiable damages or other obligations of the Company to
       Promega as provided in the Purchase Agreement; and

<PAGE>

     * a cash payment from Promega to the Company of $1,250,000.

EXPECTED PROCEEDS OF THE ASSET SALE

As set forth above, the Company expects to receive total cash
proceeds from the Asset Sale of approximately $1,500,000.  This
amount does not reflect any deductions, not to exceed $250,000,
from the proceeds that may be made for breaches of
representations and warranties discovered before or within ninety
days after the closing.  In addition to the estimated proceeds
from the Asset Sale, the Company will also have other assets at
the time of the closing of the Asset Sale, consisting primarily
of cash and cash equivalents.  As of June 30, 2000, the latest
period for which the Company has announced its financial results,
the value of this cash and cash equivalents was approximately
$990,000 before the payment of liabilities.  See "Pro Forma
Financial Information-Pro Form Balance Sheet" below.

From these other assets as they may exist at the time of the
closing, the Company must retain sufficient funds to meet its
obligations, including its then existing and contingent
liabilities, as well as its costs of dissolution.  Assets will be
retained to cover (a) known or contingent and future claims, (b)
professional fees and other expenses of management and
dissolution, and (c) various other liabilities, expenses and
obligations of the Company that will be incurred by the Company
and any liquidating trust.  See "Proposal Two-Distributions to
Stockholders" below.  After deducting (a) an estimated $500,000
to cover the above described costs and accrued expenses; and (b)
up to $250,000 pursuant to the Company's obligation to indemnify
Promega for ninety days after the closing for any breach of the
Purchase Agreement and other liabilities, from the sum of the gross
proceeds and the Company's remaining cash and cash equivalents,
the Company anticipates that the total amount available for
distribution to the stockholders in a single distribution upon
completion of the Asset Sale and the Plan of Dissolution will be
approximately $1.00 per share of the Company's outstanding common
stock ($1,158,249.00 in the aggregate).  See "Proposal Two-
Distributions to Stockholders" below.

EXPECTED TIMING OF THE ASSET SALE

The Purchase Agreement provides that the closing is to occur on
the second business day following the satisfaction by the Company
or waiver by the Buyer of all conditions precedent to the Buyer's
obligation to consummate the Asset Sale, including stockholder
approval pursuant to this proxy solicitation, and in all events
not later than November 30, 2000.

REPRESENTATIONS AND WARRANTIES; CLOSING CONDITIONS

The Purchase Agreement contains representations and warranties by
the Company to Promega customary for transactions of this type,
including representations regarding the Company and its assets.

The parties' obligations to consummate the Asset Sale are subject
to the satisfaction or waiver of conditions customary for
transactions of this type, including: (a) approval by the
Company's stockholders, (b) there being no court order or other
governmental prohibition or restraint preventing the consummation
of the transactions, (c) each of the parties having complied with
or performed all required obligations (except any for which a
failure to comply or perform does not

<PAGE>

have a material adverse effect on the transaction); and (d) the
representations and warranties of the other party being true and
correct, with certain materiality exceptions.

INDEMNIFICATION BY SELLER

The Purchase Agreement provides that the Company shall indemnify
Promega in an amount not to exceed $250,000, which amount Promega
may offset against the $250,000 purchase price promissory note
from Promega to the Company, for any losses and expenses suffered
by Promega resulting from (a) the inaccuracy or breach of  any
representation or warranty of the Company in the Purchase
Agreement, (b) any breaches or default in the performance of the
Company of any of its covenants, obligations, or agreements in
the Purchase Agreement, (c) any liability of the Company not
expressly assumed by Promega pursuant to the Purchase Agreement,
or (d) the ownership or use of the Company's assets prior to the
closing of the Asset Sale or any incident, occurrence, condition,
or claim existing, arising, or accruing prior to the closing of
the Asset Sale and relating to the operation or conduct of the
Company's business, other than any liability or obligation
expressly assumed by Promega pursuant to the Purchase Agreement.

TERMINATION OF THE PURCHASE AGREEMENT

The Purchase Agreement may be terminated at any time prior to the
closing of the Asset Sale, as follows:

     * by mutual written consent of both parties;
     * by either the Company or Promega if the other party is in
       breach of any representation, warranty, or covenant under the
       Purchase Agreement and the terminating party is not then in
       breach;
     * by Promega within the first 45 days following the date of
       the Purchase Agreement based upon Promega's due diligence
       investigation;
     * by Promega if the Asset Sale shall not have closed on or
       before November 30, 2000; or
     * by the Company if it enters into a merger, acquisition, or
       other agreement to effect a "Superior Proposal," as that term is
       defined in the Purchase Agreement, provided that in such event
       the Company shall (a) deliver notice of its intent to enter into
       an agreement to effect the Superior Proposal, (b) allow ten
       business days to elapse after delivery of such notice, (c)
       cooperate with Promega during such ten business days with the
       intent of allowing Promega to agree to modify the Purchase
       Agreement, (d) at the end of the ten business days, and acting
       through its Board of Directors, continue to reasonably believe
       that the alternative business combination constitutes a Superior
       Proposal to the Asset Sale to Promega, taking into account any
       modifications to the terms of the Purchase Agreement as may have
       been proposed by Promega, and (e) pay a "Termination Fee" of
       $100,000 to Promega.

<PAGE>

GOVERNMENT APPROVALS

No federal or state regulatory requirements or approvals must be
complied with or obtained in connection with the Asset Sale other
than compliance with applicable state corporate law and federal
and state securities laws.

NO APPRAISAL RIGHTS

Under Delaware law, the Company's stockholders have no right in
connection with the Asset Sale to dissent and seek appraisal of
their shares of Common Stock.

ACCOUNTING TREATMENT OF THE ASSET SALE

The Asset Sale will be reflected on the Company's financial
statements as a sale of assets and certain liabilities for
accounting purposes, with a gain or loss recognized in the year
in which the Asset Sale is consummated in the amount of the
difference between the purchase price and the aggregate net book
value of the assets sold to Promega.

FEDERAL INCOME TAX CONSEQUENCES OF THE ASSET SALE

The following summary of the material federal income tax
consequences of the Asset Sale is not intended to be tax advice
to any person, nor is it binding upon the Internal Revenue
Service.  In addition, no information is provided herein with
respect to the tax consequences of the Asset Sale under
applicable state, local, or foreign tax laws.

The Company will recognize gain or loss from the Asset Sale in an
amount equal to the difference between the amount realized by the
Company from the Asset Sale and the Company's adjusted tax basis
in the assets sold.  The amount realized by the Company from the
Asset Sale will equal the sum of (a) the money received by the
Company from Promega, (b) the amount of the liabilities assumed
by Promega, and (c) the aggregate amount of liabilities to which
the sold assets are subject, if any.  The Company will be subject
to federal income tax on any gain it recognizes from the Asset
Sale.  However, because the Company has significant net operating
loss carry-forwards available to it to offset any gain from the
Asset Sale, the Company does not expect to incur any significant
federal tax liability as a result of the Asset Sale.

The Company's stockholders receiving liquidating distributions
pursuant to the Plan of Dissolution should generally be
unaffected by any gain or loss recognized by the Company on the
Asset Sale.  Liquidating distributions received by stockholders
pursuant to the Plan of Dissolution should be treated as full
payment for such stockholder's shares.  Consequently, each
stockholder receiving liquidating distributions will recognize
gain or loss (which generally should qualify for capital gain or
loss treatment) equal to the difference between the amount of the
distribution and the stockholder's basis in the Company's shares.
As each stockholder will have a different basis in his/her/its
shares, each stockholder will be responsible for calculating
his/her/its own gain or loss in connection with the liquidating
distributions it receives from the Company.  See "Federal Income
Tax Consequences of Dissolution and Liquidation" below.

<PAGE>

            Price Range of Common Stock and Warrants
              Preceding Announcement of Asset Sale

The Asset Sale was publicly announced by the Company on September
5, 2000.  The high and low sale prices are shown below for the
Company's Common Stock and Warrants on September 1, 2000, the
last trading day before the announcement.

            Common Stock                    Warrants
          High        Low                 High      Low

         $1.125      $0.75              $0.0938   $0.0625


     Interest of Certain Persons in Matters to be Acted Upon

Promega's Chairman, President, and Chief Executive Officer,
William A. Linton, is a former Chairman and director of the
Company.  Mr. Linton resigned as Chairman and a director of the
Company at the Company's Annual Shareholders' Meeting on March
23, 1999.  Neither the Asset Sale nor the Plan of Dissolution
were considered by the Company's Board of Directors during the
time that Mr. Linton was Chairman and a director of the Company.
As of September 29, 2000, Mr. Linton beneficially owns 64,125
shares of the Company's Common Stock, representing 5.5% of the
outstanding Common Stock of the Company, and which includes
32,813 shares owned by Promega over which Mr. Linton may be
deemed to have voting and investment power.

Fitchburg Research Park Associates Limited Partnership, a
Wisconsin limited partnership of which Mr. Linton is the sole
general partner and with a 50% ownership interest, holds a Stock
Warrant entitling it to purchase one share of the Company's
Common Stock for every four shares issued to employees pursuant
to the Company's Stock Option Plans.  Currently, under the terms
of this Stock Warrant, the partnership may purchase an additional
131 shares at an exercise price of $0.02 per share.

In September 1991, Promega agreed to purchase shares of the
Company's Common Stock conditioned upon its receipt of an
exclusive and confidential first right, for a period of 10 years,
to review any technology developed by the Company that is
incidental to the human and animal therapeutic and diagnostic
markets.  "Incidental" refers to those markets that are not human
or animal therapeutics or diagnostics.  Promega serves various
incidental markets, such as research products or food testing.
The arrangement was established so that the Company's core
business interests would not be encumbered by the agreement with
Promega and a market could be established in incidental markets.
Promega has 60 days after disclosure of a technology to review
the technology and notify the Company in writing of its interest
in developing the technology.  The parties will then negotiate in
good faith for up to 60 days thereafter regarding terms on which
Promega might obtain the right to use the technology.  If Promega
and the Company fail to enter into an agreement within 60 days
after notice of Promega's interest in the technology, the Company
may attempt to license or assign the rights to the product to a
third party, subject to Promega's right to first refuse the price
and terms offered by a third party, exercisable within 15 days
after notice thereof to Promega.  The agreement with Promega will

<PAGE>

terminate at any time that Promega's ownership of the Company
falls below one percent of the outstanding shares.  Promega
currently owns 32,813 shares of the Company's Common Stock, or
2.8% of the outstanding shares.

On January 1, 1994, the Company entered into a Lease with Promega
for a 10,000 square foot office/research laboratory and
production facility at 5445 East Cheryl Parkway, Madison,
Wisconsin.  The lease provides for a five-year lease term with an
option to renew the lease for an additional five-year term.  In
June 1998, the Company exercised this option.  The facility lease
described above gives Promega the right to terminate in case of a
broad range of events of default by the Company, in which event
the Company would lose the value of improvements and may be
liable for the remaining rent even if its rights to use the
premises are terminated.

                          Vote Required

Under Delaware law, the affirmative vote of the holders of a
majority of the outstanding shares of the Company's Common Stock
is required to approve the Asset Sale.

                   Recommendation of the Board

THE BOARD UNANIMOUSLY RECOMMENDS THAT THE STOCKHOLDERS VOTE "FOR"
THE PROPOSAL TO APPROVE THE ASSET SALE.

           PROPOSAL TWO - APPROVAL OF THE DISSOLUTION
                 AND LIQUIDATION OF THE COMPANY

                   Proposed Stockholder Action

The Company's Board of Directors (the "Board") unanimously
approved the proposed dissolution and Plan of Dissolution &
Liquidation (collectively and hereafter referred to as the "Plan
of Dissolution") on August 28, 2000, subject to the approval of
the stockholders at the Special Meeting.  The Plan of Dissolution
provides that upon its approval by the stockholders, the Board,
without further action by the stockholders, may (a) dissolve the
Company, (b) liquidate its assets, (c) pay, or provide for the
payment of, any remaining, legally enforceable obligations of the
Company, and (d) distribute any remaining assets to the
stockholders.  Under Delaware law, approval by the holders of a
majority of the outstanding shares of the Company's Common Stock
is required to approve the Plan of Dissolution

             Description of the Plan of Dissolution

Certain material features of the Plan of Dissolution are
summarized below.  This summary is qualified in its entirety by
reference to the complete text of the Plan of Dissolution and the
relevant portions of the General Corporation Law of Delaware.  A
complete copy of the Plan of Dissolution is attached to this
Proxy Statement as Exhibit B.  Stockholders should carefully read
the Plan of Dissolution in its entirety.

<PAGE>

BACKGROUND AND REASONS FOR THE DISSOLUTION

After an extensive exploration and evaluation of various
strategic alternatives that would protect the rights of creditors
and enhance stockholder value, the Board adopted a resolution
approving the Plan of Dissolution.  The Board believes that the
dissolution and liquidation of the Company would protect the
Company's creditors and enhance stockholder value and is in the
best interests of the Company and its stockholders.

RISK FACTORS

Before deciding whether to vote in favor of this proposal to
dissolve and liquidate the Company pursuant to the Plan of
Dissolution, stockholders should consider certain risk factors,
including:

     * stockholder liability to the extent of any distributions if
       the contingency reserve is insufficient to satisfy the Company's
       liabilities; and
     * the distribution(s) to stockholders may be delayed or less
       than projected.

See "Risk Factors Relating to the Asset Sale and Plan of
Dissolution," above, for a more complete discussion of the
considerations that stockholders should take into account before
deciding whether to vote in favor of this proposal to dissolve
and liquidate the Company.

DISSOLUTION AND LIQUIDATION PROCEDURE

Following approval of the Plan of Dissolution by the holders of a
majority of the Common Stock and completion of the Asset Sale,
the Company will file a certificate of dissolution with the
Secretary of State of the State of Delaware and the dissolution
will be effective.  Once the certificate of dissolution is filed
and the Plan of Dissolution is effective, the steps taken to wind
up the Company's affairs as described below will be completed at
such times as the Board, in its absolute discretion, deems
necessary, appropriate, or advisable to maximize the value of the
Company's assets upon liquidation; provided that such steps may
not be delayed longer than is permitted by applicable law.

ABANDONMENT OF THE PLAN OF DISSOLUTION

By approving the Plan of Dissolution, stockholders will also be
granting the Board the authority, notwithstanding the
stockholders' approval of the Plan of Dissolution, to abandon the
Plan of Dissolution without further stockholder action, to the
extent permitted by Delaware law, if the Board of directors
determines that dissolution and liquidation are not in the best
interests of the Company and its stockholders.

<PAGE>

CONDUCT OF THE COMPANY FOLLOWING DISSOLUTION

Once the Company's certificate of dissolution is filed and
effective, the Company will cease to exist for the purpose of
continuing its business, but will nevertheless continue, for a
term of three years or such longer period as the Delaware Court
of Chancery directs, for the purpose of winding up the Company's
affairs.  During this time, the Company will undertake the
following tasks:

     * settle and close its business;
     * convert to cash, by sales, as much of the Company's
       remaining non-cash assets as possible;
     * withdraw from any jurisdiction where it is qualified to do
       business;
     * pay or make provision for the payment of all of the
       Company's expenses and liabilities;
     * prosecute and defend lawsuits, if any
     * distribute the Company's remaining assets, which should be
       primarily cash, but which may consist of other financial assets,
       to the stockholders; and
     * do any other act necessary to wind up and liquidate the
       Company's business and affairs.

The Board and the remaining officers of the Company will oversee
the Company's dissolution and liquidation.

SALE OF REMAINING ASSETS

The Plan of Dissolution gives the Board, to the fullest extent
permitted by law, the authority to sell all of the Company's
assets.  Accordingly, stockholder approval of the Plan of
Dissolution will constitute, to the fullest extent permitted by
law, approval of the Company's sale of any and all of its assets
remaining after the dissolution, on such terms and conditions as
the Board, in its absolute discretion and without further
stockholder approval, may determine.  Notwithstanding the
separate approval the Board is seeking at the Special Meeting for
the Asset Sale, the Board will have the authority to sell all of
the Company's assets in alternate transactions after the
Company's dissolution pursuant to stockholder approval of the
Plan of Dissolution, without further stockholder action or
approval, even if either of the following should occur:

     * the stockholders fail to approve the Asset Sale; or
     * the Asset Sale is not consummated as contemplated.

PAYMENT OF CLAIMS AND OBLIGATIONS.

In accordance with Delaware law, before distributing any assets
to stockholders, the Company will pay and discharge, or make
provisions as will be reasonably likely to provide sufficient
compensation for the following:

     * all claims and obligations, including all contingent,
       conditional, or unmatured contractual claims known to the
       Company;

<PAGE>

     * any claim against the Company which is the subject of a
       pending action, suit, or proceeding to which the Company is a
       party; and
     * claims that have not been made known to the Company or that
       have not arisen, but that, based on facts known to the Company,
       are likely to arise or become known to the Company within ten
       years after the certificate of dissolution becomes effective.

DISTRIBUTIONS TO STOCKHOLDERS

Claims, liabilities, and expenses from operations, including
operating costs, salaries, income taxes, payroll and local taxes,
and miscellaneous office expenses, will continue to occur
following approval of the Plan of Dissolution.  The Company
anticipates that expenses for professional fees and other
expenses of liquidation will be significant.  These expenses will
reduce the amount of assets available for ultimate distribution
to stockholders.  Before making any distribution to stockholders,
the Board must first make adequate provision for the payment,
satisfaction, and discharge of all known, unascertained, or
contingent debts and liabilities, including costs and expenses
incurred and anticipated to be incurred in connection with the
sale of any assets remaining after the dissolution.

The Board will determine, in its sole discretion and in
accordance with applicable law, the timing of, the amount, the
kind of, and the record date for any distribution made to
stockholders.  Liquidating distributions will be made to
stockholders on a pro rata basis. The Company is not required to
pay all of its liabilities and obligations prior to making
distributions to stockholders, but instead, will reserve assets
in a contingency reserve deemed by management and the Board to be
adequate to provide for such liabilities and obligations when
due.  Although the Board has not established a firm timetable for
any distribution to stockholders, after the dissolution has
become effective, the Board will, subject to exigencies inherent
in winding up the Company's business, make a final distribution
as promptly as practicable.

Uncertainties as to the precise net value of the Company's assets
and the ultimate amount of its liabilities make it impossible to
predict with certainty the aggregate net values that will
ultimately be distributed to stockholders or the timing of any
distribution.  Based on information presently available, the
Company estimates that it will distribute an aggregate of $1.00
per share in a single distribution to holders of the Company's
Common Stock.  The Company anticipates that this distribution to
stockholders will occur in the first quarter of calendar year
2001.  See "Pro Forma Financial Information" below.

Stockholders should not send their stock certificates with the
enclosed proxy.  Following the Company's dissolution,
stockholders will be sent additional instructions for receiving
distributions.

In addition to the Company's outstanding Common Stock, the
Company has outstanding warrants for the purchase of
approximately 241,636 shares of Common Stock, which warrants are
listed and traded on the NASDAQ SmallCap System and the Pacific
Exchange (the "Warrants").  As a result of the one-for-eight
reverse stock split on September 20, 1999, and other adjustments
to the exercise price, the current exercise price of the Warrants
is $55.615 per share.  As of the date hereof, it is not
anticipated that the price of the Common Stock will reach or
surpass this amount at any time prior to the Company's
dissolution.  No distribution will paid

<PAGE>

with respect to the Warrants, which will be cancelled as of the
record date for any distribution to stockholders.

ALL DISCUSSION IN THIS PROXY STATEMENT CONCERNING THE AMOUNT PER
SHARE OF COMMON STOCK OF ASSET SALE PROCEEDS AND OF EXPECTED
DISTRIBUTIONS, INCLUDING ALL PRO FORMA FINANCIAL STATEMENT
PRESENTATION OF THESE ITEMS, ASSUMES THAT NO WARRANTS WILL BE
EXERCISED FOR PURCHASE OF THE COMMON STOCK.  IF THE PRICE OF THE
COMMON STOCK WERE TO RISE SUFFICIENTLY TO PUT THE OUTSTANDING
WARRANTS "IN THE MONEY" AND HOLDERS THEREOF EXERCISED THEIR
WARRANTS, THE NUMBER OF SHARES OF OUTSTANDING COMMON STOCK WOULD
INCREASE AND THE AMOUNT AVAILABLE FOR DISTRIBUTION PER SHARE OF
OUTSTANDING COMMON STOCK WOULD DECREASE PROPORTIONALLY.

LIQUIDATION TRUST

If deemed advisable by the Board for any reason, the Company may,
following dissolution, transfer any of its assets to a trust
established for the benefit of stockholders, subject to the
claims of creditors.  Thereafter, these assets will be sold or
distributed on terms approved by the trustees.  In any event, if
all of the Company's assets have not otherwise been distributed
within three years after dissolution, the Company will transfer
all of its remaining assets to the liquidating trust.  The Board
is authorized to appoint one or more trustees of the liquidating
trust and to cause the Company to enter into a liquidating trust
agreement with the trustee(s) on such terms and conditions as may
be approved by the Board.  Stockholder approval of the Plan of
Dissolution will also constitute approval of any such appointment
and any liquidating trust agreement.

DELISTING AND TRADING OF THE COMMON STOCK AFTER DISSOLUTION

The Company's Common Stock and warrants are listed for trading on
the NASDAQ Stock Market's SmallCap System and the Pacific
Exchange.  Following dissolution, the Board will determine the
appropriate time to delist the Common Stock and warrants from
these exchanges. Thereafter, trading, if any, in the Common Stock
and warrants would be conducted in the over-the-counter market in
the so-called "pink sheets" or the NASD's "Electronic Bulletin
Board."  As a consequence of such delisting, an investor would
likely find it more difficult to dispose of, or obtain quotations
as to the price of, the Common Stock and warrants.  Delisting of
the Common Stock and warrants may result in lower prices for
these securities than would otherwise prevail.

CONTINUING LIABILITY OF STOCKHOLDERS AFTER DISSOLUTION

Following the Company's dissolution and liquidation, it is
possible that some claims may still exist that could be asserted
against the Company.  Delaware law provides that, if the assets
of a corporation are distributed in connection with the
dissolution of a corporation, a stockholder may be liable for
claim(s) against the corporation.  In such event, a stockholder's
potential liability for any such claim against the Company would
be limited to the lesser of (a) the stockholder's pro

<PAGE>

rata share of such claim or (b) the actual amount distributed to
the stockholder in connection with the dissolution.

An individual stockholder's total liability for any claims
against the Company after it is dissolved will not exceed the
amount actually distributed to that stockholder in the
dissolution.

NO APPRAISAL RIGHTS

Under Delaware law, stockholders are not entitled to dissenters'
or appraisal rights with respect to the Plan of Dissolution.

REGULATORY MATTERS

Except for the Company's filing of the certificate of dissolution
with the Secretary of State of the State of Delaware, the Company
is not subject to any federal or state regulatory requirements
nor is it required to obtain any federal or state approval in
order to consummate the dissolution.

             Certain Federal Income Tax Consequences

GENERAL

The following discussion is a general summary of the federal
income tax consequences that may result from the dissolution and
liquidation of the Company and the distribution of its assets to
its stockholders pursuant to the Plan of Dissolution.  This
summary is based on the provisions of the Internal Revenue Code
as currently in force, but which is subject to change.  Any such
change may be applied retroactively.

This summary does not discuss all aspects of federal income
taxation that may be relevant to a particular stockholder or to
certain types of persons subject to special treatment under
federal income tax laws, such as corporations and non-US persons,
nor does it address any aspects of state, local or foreign tax
laws.  Because any distributions made pursuant to the Plan of
Dissolution may occur at various times and in more than one tax
year, no assurances can be given that the tax treatment described
herein will continue to apply unchanged at the time of later
distributions.

We have not requested a ruling from the IRS or obtained an
opinion of counsel with respect to the anticipated tax treatment
of the Plan of Dissolution.  If any of the conclusions stated
under "Certain Federal Income Tax Consequences" proves to be
incorrect, the result could be increased taxation at the
corporate and/or stockholder level, thus reducing the benefit to
the creditors and possibly stockholders and the Company from the
liquidation.  This summary does not address tax consequences that
may vary with, or are contingent on, individual circumstances.
Accordingly, this summary does not constitute legal advice to any
stockholder.

The Company recommends that each stockholder consult his or her
personal tax advisor regarding the specific federal, state and
local tax consequences of the Plan of Dissolution.

<PAGE>

CONSEQUENCES TO THE COMPANY

After the Plan of Dissolution becomes effective and until the
liquidation is completed, the Company will continue to be subject
to income tax on its taxable income.  The Company will recognize
gain or loss on sales of its property pursuant to the Plan of
Dissolution.  Upon distributions, if any, of property, other than
cash, to stockholders pursuant to the Plan of Dissolution, the
Company will recognize gain or loss as if such property was sold
to stockholders at its fair market value, unless certain
exceptions to the recognition of loss apply.  As it is
anticipated that no such exception will apply, the Company should
recognize gain or loss on any distribution of property to
stockholders pursuant to the Plan of Dissolution.

The Company may discharge its liabilities at less than the face
amount of such liabilities. The discharge of liabilities, at less
than face amount, may result in the Company's realization of
income to the extent of the excess of the face amount of the
liabilities over the amount paid in satisfaction thereof.

CONSEQUENCES TO STOCKHOLDERS

As a result of the Company's liquidation, stockholders will
recognize gain or loss equal to the difference between (a) the
sum of the amount of cash distributed to them and the fair market
value (at the time of distribution) of property distributed to
them, and (b) their adjusted tax basis of their shares.  The
adjusted tax basis in a stockholder's shares will depend upon
various factors, including the cost of the shares and the amount
and nature of any distributions received from the Company with
respect to the stock.

Gain or loss recognized by a stockholder will be capital gain or
loss, provided the shares are held as capital assets.  Capital
gains are long term if the stock is held for more than twelve
months.  For individuals, the maximum federal income tax rate
applicable to long term capital gains is generally 20%.
Deductions for capital losses, whether short or long term, are
subject to various limitations.

In the unlikely event that the Company makes any distribution of
property other than cash, a stockholder's tax basis in such
property immediately after the distribution will be the fair
market value of such property as of the time of distribution.
The gain or loss realized upon a stockholder's future sale of
that property will be measured by the difference between the
stockholder's tax basis in the property at the time of such sale
and the sales proceeds.

After the close of the Company's taxable year, the Company will
provide stockholders and the IRS with a statement of the amount
of cash distributed to them and the Company's best estimate as to
the value of the property, if any, distributed to stockholders
during that year.  In the case of property, the Company will
determine the fair market value based upon reports by independent
appraisers or such other evidence as the Company shall elect.
There is no assurance that the IRS will not challenge such
valuation.  As a result of such a challenge, the amount of gain
or loss recognized by a stockholder might be changed.
Distributions of property other than cash to a stockholder could
result in a stockholder's tax liability exceeding the amount of
cash he or she received, requiring him or her to meet the tax
obligations from other sources.

<PAGE>

If the Company transfers assets to a liquidating trust,
beneficial ownership in the trust will be distributed to the
stockholders.  For federal income tax purposes, stockholders
would be treated at the time of transfer as having received their
pro rata share of assets transferred to the liquidating trust,
reduced by the amount of known liabilities assumed by the
liquidating trust or to which the assets are subject.  The
liquidating trust itself should not be subject to tax.  After
formation of the liquidating trust, the stockholders must take
into account, for federal income tax purposes each year, their
allocable portion of any income, expense, gain or loss recognized
by the trust. As a result of the transfer of property to the
trust and ongoing operations of the trust, stockholders should be
aware that they may be subject to tax, whether or not they have
received any actual distributions from the liquidating trust with
which to pay the tax.

                          Vote Required

Under Delaware law, the affirmative vote of the holders of a
majority of the outstanding shares of the Company's Common Stock
is required to approve the Plan of Dissolution.  If the requisite
number of stockholders approve the Plan of Dissolution, the
Company will be dissolved and liquidated in accordance with the
Plan of Dissolution even though individual stockholders may have
voted against the proposal.  The Plan of Dissolution may be
amended or terminated, either before or after stockholder
approval has been obtained, unless the Board determines that such
amendment or termination would materially and adversely affect
the stockholders' interests.

                   Recommendation of the Board

THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT STOCKHOLDERS
VOTE "FOR" THE PROPOSAL TO APPROVE THE PLAN OF DISSOLUTION.

                          OTHER MATTERS

The Company knows of no other matters to be submitted at the
meeting.  If any other matters properly come before the meeting,
the proxy holders will vote the shares they represent as the
Board of directors may recommend.

             OTHER INFORMATION REGARDING THE COMPANY

The following additional information about the Company is
provided as required by Regulation and Schedule 14A of the
General Rules and Regulations under the Securities and Exchange
Act of 1934, as amended.

         Voting Securities and Principal Holders Thereof

The following table sets forth the beneficial ownership of the
Company's securities as of September 29, 2000, by (a) each person
known by the Company to be the beneficial owner of more than 5%
of any class of the Company's securities, (b) the directors of
the Company, (c) the executive officers of the Company, and (d)
all directors and executive officers as a group.  As of September
29, 2000, a total of 1,158,249 shares of the Company's Common
Stock, 241,636 of

<PAGE>

the Company's Common Stock ($7.32) Purchase Warrants, and
125,000 of the Company's Common Stock ($2.00) Purchase
Warrants were issued and outstanding.

<TABLE>
                                                               Number of                   Number of
                                    Number of                    $7.32                      $2.00
                                     Shares                     Warrants                   Warrants
Name and Address of                Beneficially   Percentage  Beneficially    Percentage  Beneficially   Percentage
Beneficial Owner                    Owned (1)       Owned       Owned (2)       Owned      Owned (2)       Owned
      <S>                             <C>            <C>          <C>            <C>          <C>           <C>

Dr. Margaret B. van Boldrick (3)     167,350         14.4
Eli Lilly and Company
  Lilly Corporate Center,
  Indianapolis, IN  46285             87,412          7.6
Dr. Peter Model (4)                   68,190          5.6        5,625            2.3
Mr. William A. Linton                 64,125          5.5
Mr. Rex J. Bates (6)                  55,350          4.8        1,144            *         500,000         50.0
Mr. Davis U. Merwin                   54,706          4.7        1,144            *         500,000         50.0
Dr. W. Leigh Thompson (7)              2,630          *
Ms. Susan P. Maynard (8)               2,286          *
All Directors and Officers as a
Group (4 persons) (9)(10)            240,456         20.8        7,913            3.3     1,000,000        100.0

</TABLE>
          *Less than 1%.

(1)  Includes ownership of shares of Common Stock plus options
     exercisable within 60 days of September 29, 2000.  Shares of
     Common Stock subject to outstanding options are deemed
     outstanding for purposes of computing the percentage of ownership
     of the person holding such options but are not deemed outstanding
     for computing the percentage ownership for any other persons.

(2)  The exercise prices listed reflect the original exercise
     prices for these warrants prior to the eight-for-one reverse
     split of the Company's Common Stock effective September 20, 1999
     (the "Reverse Split").  Following the Reverse Split, and pursuant
     to the underlying warrant agreements governing the exercise and
     other terms of the Company's warrants, the per share exercise
     prices are now $55.615 and $16.00, respectively, for the $7.32
     and $2.00 Common Stock purchase warrants.

(3)  Dr. van Boldrik's beneficial ownership includes 156,100
     shares owned by Dr. van Boldrik, 5,625 shares held by the Willem
     Erin Samburu Carroll van Boldrik Trust A and 5,625 shares held by
     the Jan Patrick Jabiru van Boldrik Carroll Trust A.   Dr. van
     Boldrik is the sole trustee for both trusts.

(4)  Includes 56,875 shares held by the Model Charitable Lead
     Trust and Peter Model Trust II, for which Dr. Model is one of two
     co-trustees, and options to purchase 668 shares currently vested
     in the 1992 Stock Option Plan, which options expire in January
     2007, and options to purchase 1,250 shares currently vested in
     the 1992 Stock Option Plan, which options expire in November
     2009.

(5)  Includes 32,813 shares owned by Promega Corporation of which
     Mr. Linton is Chairman, President, and Chief Executive Officer
     and may be deemed to have voting and investment power over the
     shares.

(6)  Includes (a) options to purchase 3,125 shares currently
     vested in the 1992 Stock Option Plan, which options expire in
     July 2006; (b) options to purchase 625 shares currently vested in
     the 1992 Stock Option Plan, which options expire in January 2006;
     (c) options to purchase 625 shares currently vested in the 1992
     Stock Option Plan, which options expire in January 2007; and (d)
     options to purchase 1,250 shares currently vested in the 1992
     Stock Option Plan, which options expire in November 2009.

(7)  Includes (a) options to purchase 665 shares currently vested
     in the 1992 Stock Option Plan, which options expire in January
     2006; (b) options to purchase 625 shares currently vested in the
     1992 Stock Option Plan, which options expire in January 2007; and
     (c) options to purchase 1,250 shares currently vested in the 1992
     Stock Option Plan, which options expire in November 2009.

<PAGE>

(8)  Includes options to purchase 2,224 shares currently vested
     in the 1998 Incentive Stock Option Plan, which options expire in
     November 2009.

(9)  Address is 5445 East Cheryl Parkway, Madison, Wisconsin
     53711.

(10) Includes options to purchase a total of 12,307 shares, which
     options have vested, or will vest, within 60 days of September
     29, 2000.

                       Changes in Control

On February 10, 1999, Dr. Sean Carroll, then an owner of 15.8% of
the Common Stock of the Company, completed a sale of a total of
115,000 of his shares, approximately 10% of the Company's
outstanding Common Stock.  The purchasers were the Rex James
Bates Trust, Davis U. Merwin, the Model Charitable Lead Trust,
Dr. Peter Model, and the Peter Model Trust No. 2.  Peter Model is
the Company's Chairman and a director of the Company and a
trustee for the respective trusts.  Davis U. Merwin is an
existing stockholder of the Company.  Upon completion of the
transaction, none of the purchasers were the beneficial owner of
10% or more of the Company's Common Stock.

On June 7, 1999, the Company entered into separate Promissory
Note and Loan Agreements with Rex J. Bates, then a director and
currently a stockholder, and Davis U. Merwin, a stockholder,
pursuant to which the Company borrowed $2 million on October 14,
1999, in exchange for ten-year, 10%, senior notes with warrants.
The assets of the Company secure the notes.  Interest on the
notes for the first three years is payable in Common Stock of the
Company at the then market value and thereafter in cash.  The
warrants for the purchase of 125,000 shares of Common Stock are
exercisable for five years at $16.00 per share.

Other than the above-described transactions and the proposed
Asset Sale, the Company is not aware of any arrangement or plan
by, with, or among any party or parties that would result in a
change in control of the Company or whereby one or more persons
would act in concert with respect to any matter affecting the
Company.

    Selected Financial Data, Including Pro Forma Information

The following tables set forth selected financial data on a
historical basis and on a pro forma basis for the Company after
giving effect to (a) the Asset Sale and (b) certain prior
property dispositions. The financial data should be read in
conjunction with the Company's financial statements and notes
thereto incorporated by reference into this Proxy Statement.  The
historical financial data as of June 30, 2000, and for the nine
months then ended, has been derived from unaudited financial
statements, which, in the opinion of the Company's management,
include all adjustments, consisting only of normal recurring
adjustments, necessary for a fair statement of the results for
the unaudited interim periods.

The unaudited pro forma balance sheet as of June 30, 2000, is
presented as if the transactions had occurred on June 30, 2000.
The unaudited pro forma operating data for the nine months ended
June 30, 2000, is presented as if (a) the Asset Sale and (b)
certain prior property dispositions had occurred on October 1, 1999.

<PAGE>

The pro forma information included in "Selected Financial Data"
is based upon assumptions that are included in the "Notes to the
Pro Forma Financial Statements" set forth below.  The pro forma
information is unaudited and is not necessarily indicative of
what the financial position and results of operations of the
Company would have been as of and for the dates or periods
indicated, nor does it purport to represent the future financial
position and results of operations for future dates or periods.

<PAGE>

            PRO FORMA FINANCIAL INFORMATION

             OPHIDIAN PHARMACEUTICALS, INC.
                PRO FORMA BALANCE SHEET
                    JUNE 30, 2000
                     (UNAUDITED)

                                HISTORICAL                        PRO FORMA
                             (June 30, 2000)   ASSET SALE     (June 30, 2000)

ASSETS
 Cash and cash equivalents    $    990,179   $  1,250,000 A    $  2,240,179
 Promissory note receivable              -        250,000 A         250,000
 Equipment and leasehold
     improvements, net           4,254,361     (4,254,361) B              -
 Patent costs, net               1,535,983     (1,535,983) C              -
 Other assets                        8,294              -             8,294
                             _______________________________________________
   Total assets               $  6,788,817    $(4,290,344)      $ 2,498,473
                             ===============================================

LIABILITIES AND STOCKHOLDERS'
EQUITY
 Accounts payable             $    306,554    $         -       $   306,554
 Accrued liabilities               197,847              -           197,847
 Capital leases                     10,500        (10,500) D              -
 Senior notes                    1,628,494     (1,628,494) E              -
 Deffered revenue                  354,310       (354,310) F              -
                             _______________________________________________
   Total liabilities             2,497,705     (1,993,304)          504,401
                             ===============================================

 Common stock                        2,895              -             2,895
 Additional paid-in-capital     22,507,322              -        22,507,322
 Accumulated deficit           (18,219,105)    (2,297,040)      (20,516,145)
                             _______________________________________________
   Total stockholders' equity    4,291,112     (2,297,040)        1,994,072
                             ===============================================

     Total liabilities and   _______________________________________________
       stockholders' equity   $  6,788,817    $(4,290,344)      $ 2,498,473
                             ===============================================

See accompanying notes

<PAGE>

                OPHIDIAN PHARMACEUTICALS, INC.
               PRO FORMA STATEMENT OF OPERATIONS
            FOR THE NINE MONTHS ENDED JUNE 30, 2000
                         (UNAUDITED)

                               HISTORICAL                    PRO FORMA
                           (June 30, 2000)  ASSET SALE    (June 30, 2000)
Revenues
 Sales of patents           $   1,300,000  $         -     $   1,300,000
 Other                             14,224      354,310 F         368,534
                            _____________________________________________
   Total revenues               1,314,224      354,310         1,668,534

Operating expenses
 Cost of patents sold              83,481            -            83,481
 Research and development       1,875,074            -         1,875,074
 General and administrative     1,352,147            -         1,352,147
 Loss on sale of assets                 -    2,279,844 G       2,279,844
                            _____________________________________________
   Total operating expenses     3,310,702    2,279,844         5,590,546

Operating loss                 (1,996,478)  (1,925,534)       (3,922,012)
Non-operating income, net          89,951            -            89,951
                            _____________________________________________
Loss before extraordinary item (1,906,527)  (1,925,534)       (3,832,061)
Extraordinary item - early
     extinguishment of debt             -     (371,506) E       (371,506)
                            _____________________________________________
Net loss                    $  (1,906,527) $(2,297,040)       (4,203,567)
                            =============================================
                            _____________________________________________
Net loss per share - basic
     and diluted            $       (1.65) $     (1.98)   $        (3.63)
                            =============================================

See accompanying notes


             Notes to Pro Forma Financial Statements

A  The adjustment to cash and cash equivalents and promissory
   note receivable reflects the estimated gross proceeds of
   approximately $1,500,000 from the proposed Asset Sale.  This
   amount does not reflect any deductions, not to exceed
   $250,000, from the gross proceeds that may be made pursuant
   to the Company's obligation, as set forth in the Purchase
   Agreement, to indemnify Promega for any "Indemnifiable
   Damages" incurred by Promega within 90 days of the closing of
   the Asset Sale.  The Company also expects to incur an
   additional $500,000 of expenses for accrued taxes and other
   accrued costs,

<PAGE>

   and estimated legal, accounting, closing,
   insurance, stockholder communications, and related expenses
   of officers and employees assigned to complete the
   dissolution and liquidation. The actual costs incurred could
   vary significantly due to uncertainties related to the timing
   and closing of the Asset Sale, the length of time required to
   complete the Plan of Dissolution, and complexities that may
   arise in disposing of the Company's assets if the Asset Sale
   is not completed.  All such costs will be paid before any
   distribution will be made to stockholders.

B  The adjustment to equipment and leasehold improvements
   represents the carrying value of the equipment and leasehold
   improvements sold.

C. The adjustment to patents represents the carrying value of
   the patents sold.

D. The adjustment to capital leases represents the carrying
   value of the leases assumed by Promega.

E. The adjustment to senior notes represents $2,000,000 of debt
   assumed by Promega Corporation, offset by the $371,506 debt
   discount, which will be expensed upon early extinguishment of
   the senior notes

F. The adjustment to deferred revenue represents the recognition
   of patent reimbursements acquisition costs that were to be
   recognized after issuance of certain patents.  As all patents
   and pending patents are being sold, $354,310 of deferred
   revenue should be recognized.

G. Represents the estimated loss on the Asset Sale.

                      Stockholder Proposals

If the Asset Sale and the Plan of Dissolution are approved and
the Asset Sale and Plan of Dissolution are consummated in a
timely manner, the Company does not intend to hold an annual
stockholders meeting in 2001 or thereafter.  If the Asset Sale
and the Plan of Dissolution are not approved or if the
dissolution of the Company is delayed or the Plan of Dissolution
abandoned by the Board in their discretion to the extent
permitted by the terms of the Plan of Dissolution and Delaware
law, and if a stockholder desires to present any proposal for
consideration at the Company's 2001 Annual Meeting of
Stockholders, the stockholder must, in addition to satisfying any
other applicable requirements, submit such proposal to the
Company so that it is received at the Company's principal offices
not later than September 30, 2000.

               Where You Can Find More Information

The Company is subject to the informational requirements of the
Exchange Act, and in accordance therewith files reports, proxy
statements and other information with the Securities and Exchange
Commission (the "SEC").  Such reports, proxy statements and other
information filed by the Company may be inspected and copied at
the public reference facilities maintained by the SEC at 450
Fifth Street, N.W., Washington, D.C. 20549, and at the regional
offices of the SEC located at 75 Park Place, New York, New York
10007 and 500 West Madison Street, Chicago, Illinois 60661.
Copies of such material can be obtained from the Public Reference

<PAGE>

Section of the SEC at 450 Fifth Street, N.W., Washington, D.C.
20549, at prescribed rates.  In addition, most of the documents
filed by the Company with the SEC are available through the SEC's
Electronic Data Gathering and Retrieval System ("EDGAR") at the
SEC's Internet site at http://www.sec.gov.

The Company furnishes stockholders with annual reports containing
consolidated financial statements audited by independent
certified public accountants.  The Company's 1999 Annual Report,
which integrated information from the Company's Annual Report on
Form 10-K for the fiscal year ended September 30, 1999, was sent
to shareholders on or about February 23, 2000.

Stockholders should rely only on the information contained in
this Proxy Statement.  No person is authorized to give any
information or to make any representations other than the
information or representations contained herein and, if given or
made, such information or representations should not be relied
upon as having been authorized.  This Proxy Statement does not
constitute the solicitation of a proxy in any jurisdiction where,
or to any person to whom, it is unlawful to make such a
solicitation.  This Proxy Statement is dated October 8, 2000.
Stockholders should not assume that the information contained in
this Proxy Statement is accurate as of any later date, and the
mailing and delivery of this Proxy Statement shall not, under any
circumstances, create any implication to the contrary.

              Information Incorporated by Reference

The Company's Annual Report on Form 10-K for the fiscal year
ended September 30, 1999, Quarterly Report on Form 10-Q for the
fiscal quarter ended December 31, 1999, Quarterly Report on Form
10-Q for the fiscal quarter ended March 31, 2000, Quarterly
Report on Form 10-Q for the fiscal quarter ended June 30, 2000 (a
copy of which is being delivered to stockholders concurrently
with this Proxy Statement) and Current Reports on Forms 8-K filed
with the SEC on April 12, 2000, and May 26, 2000, are hereby
incorporated by reference into this Proxy Statement.  All
documents filed by the Company with the SEC pursuant to Sections
13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of
this Proxy Statement and prior to the completion of the vote at
the Meeting shall be deemed to be incorporated by reference into
this Proxy Statement and to be a part hereof from the date of
filing of such documents.  Any statement contained in a document
incorporated or deemed to be incorporated by reference herein
shall be deemed to be modified or superseded for purposes of this
Proxy Statement to the extent that a statement contained herein
or in any other subsequently filed document that also is or is
deemed to be incorporated by reference herein modifies or
supersedes such statement.  Any such statement so modified or
superseded shall not be deemed, except as so modified or
superseded, to constitute a part of this Proxy Statement.

THIS PROXY STATEMENT INCORPORATES DOCUMENTS BY REFERENCE  WHICH
ARE NOT PRESENTED HEREIN OR DELIVERED HEREWITH.  COPIES OF ANY
SUCH DOCUMENTS, OTHER THAN EXHIBITS TO SUCH DOCUMENTS WHICH ARE
NOT SPECIFICALLY INCORPORATED BY REFERENCE HEREIN, ARE AVAILABLE
WITHOUT CHARGE TO ANY PERSON, INCLUDING ANY STOCKHOLDER, TO WHOM
THIS PROXY STATEMENT IS DELIVERED, UPON WRITTEN OR ORAL REQUEST
TO THE COMPANY, 5445 EAST CHERYL PARKWAY, MADISON, WI 53711,
TELEPHONE

<PAGE>

(608) 271-0878.  IN ORDER TO ASSURE TIMELY DELIVERY OF
THE DOCUMENTS, ANY REQUEST SHOULD BE MADE BEFORE OCTOBER 31, 2000.

                            SIGNATURE

Pursuant to the requirements of Section 14 of the Securities and
Exchange Act of 1934, as amended, and Regulation 14A thereunder,
the Company has caused this Proxy Statement to be mailed to the
stockholders of the Common Stock and filed with the Securities
and Exchange Commission.

                         BY ORDER OF THE BOARD OF DIRECTORS

                         /s/ Susan P. Maynard

                         Susan P. Maynard
                         Secretary

<PAGE>

                            OPHIDIAN
                      Pharmaceuticals, Inc.
                    5445 East Cheryl Parkway
                       Madison, WI   53711

   THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

                 SPECIAL MEETING OF STOCKHOLDERS
                   TO BE HELD NOVEMBER 9, 2000

The undersigned stockholder of Ophidian Pharmaceuticals, Inc., a
Delaware corporation (the "Company"), hereby acknowledges receipt
of the Notice of Special Meeting of Stockholders and Proxy
Statement for the Special Meeting of Stockholders to be held
November 9, 2000, and appoints Peter Model and Susan Maynard, and
each of them individually, proxies, each with full power of
substitution, to vote, as specified below, all shares of Common
Stock of the Company held of record by the undersigned on
September 29, 2000, at the Special Meeting of Stockholders of the
Company to be held on November 9, 2000, at 10:00 a.m. central
standard time, at 5445 East Cheryl Parkway, Madison, Wisconsin
and any adjournments or postponements thereof.

Please complete, date, sign, and return this proxy promptly in the
envelope provided, whether you plan to attend the Special Meeting
or not.  If you do plan to attend, you may, of course, vote your
shares in person.  This proxy will be voted as directed or, if no
direction is indicated, will be voted in favor of the proposed
items of business.

Please mark vote in box, using dark ink only, in the following
manner:   /X/

1.   To approve the proposed sale of substantially all of the
     Company's assets to Promega Corporation, a Wisconsin corporation,
     pursuant to the terms of the Asset Purchase Agreement dated as of
     September 1, 2000.

       /  / For            /  / Against             /  / Abstain

  THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THE PROPOSAL.

2.   To approve the proposed authorization to the Company's Board
     of Directors to effect the dissolution and liquidation of the
     Company as described in the proposed Plan of Dissolution and
     Liquidation.

       /  / For            /  / Against             /  / Abstain

  THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THE PROPOSAL.

Please complete, date, and sign this proxy and return it promptly
in the accompanying envelope.

Date:  _________________________


Signature(s):  _____________________________  _________________________

(title/capacity):  _________________________  _________________________

Note:  Please sign exactly as your name appears on this proxy.  If
signing for an estate, trust, or corporation, your title and/or
capacity should be so stated.  If shares are held jointly, at
least one joint owner must sign.



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