AVI BIOPHARMA INC
8-A12B, 1999-03-18
PHARMACEUTICAL PREPARATIONS
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<PAGE>
                        SECURITIES AND EXCHANGE COMMISSION
                               WASHINGTON, DC 20549
                                 ____________________

                                      FORM  8-A

                FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES
                    PURSUANT TO SECTION 12(b) OR 12(g) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

                                  AVI BioPharma Inc.
                (Exact Name of Registrant as Specified in Its Charter)


               Oregon                               93-079722                   
(State of Incorporation or Organization)    (I.R.S. Employer Identification No.)
             

     One S.W. Columbia Street, Suite 1105
            Portland, Oregon                          97258                     
     (Address of Principal Executive Offices)       (Zip Code)                  
          


If this form relates to the registration of a class of securities pursuant to
Section 12(b) of the Exchange Act and is effective pursuant to General
Instruction A.(c), please check the following box. / /

If this form relates to the registration of a class of securities pursuant to
Section 12(g) of the Exchange Act and is effective pursuant to General
Instruction A.(d), please check the following box. /X/


Securities Act registration statement file number to which this form 
relates: 333-60849

Securities to be registered pursuant to Section 12(b) of the Act:

<TABLE>
<CAPTION>

Title of Each Class         Name of Each Exchange on Which
to be so Registered         Each Class is to be Registered
- -------------------        ---------------------------------
<S>                        <C>
       None 
</TABLE>

Securities to be registered pursuant to Section 12(g) of the Act:

                          Warrants to Purchase Common Stock
                                   (Title of Class)

                                       1
<PAGE>

ITEM 1.   DESCRIPTION OF REGISTRANT'S SECURITIES TO BE REGISTERED.

     The description of the Registrant's Warrants required by this Item is
incorporated by reference to the "Description of Capital Stock -- Warrants" on
pages 98 through 100 of the Registrant's Registration Statement on Form S-4,
No. 333-60849, in the form in which it was filed on August 7, 1996.


ITEM 2.   EXHIBITS.

     1.   Copy of pertinent pages of the documents containing information
incorporated by reference in Item 1 above.

     2.   Constituent instrument defining the rights of holders of the Warrants
incorporated by reference to Exhibit 4.5 of the Registrant's Statement on
Form S-4, No. 333-60849, in the form in which it was filed on August 7, 1998.

     3.   Amended and Restated Warrant Agreement between AntiVirals Inc.,
ChaseMellon Shareholder Services, L.L.C., and James C. L. Baxendale, dated as of
September 15, 1998.



                                      SIGNATURE

     Pursuant to the requirements of Section 12 of the Securities Exchange Act
of 1934, the registrant has duly caused this registration statement to be signed
on its behalf by the undersigned, thereto duly authorized.



                              AVI  BioPharma  Inc.


Date:     March 18, 1999      By:     /s/  Denis R. Burger               
       -------------------        -------------------------------------------
                              Title: President, Chief Executive Officer 
                                     and Director(Principal Executive Officer)

                                       2

<PAGE>










                                AMENDED AND RESTATED

                                  WARRANT AGREEMENT



                                       BETWEEN



                                  ANTIVIRALS INC.,

                     CHASEMELLON SHAREHOLDER SERVICES, L.L.C.

                                         AND

                               JAMES C. L. BAXENDALE



                            DATED AS OF SEPTEMBER 15, 1998



<PAGE>

          This Amended and Restated Agreement, dated as of September 15, 1998,
is between AntiVirals Inc., an Oregon corporation (the "Company"), ChaseMellon
Shareholder Services, L.L.C., a limited liability company (the "Warrant Agent"),
and James C. L. Baxendale, as representative of the shareholders of
ImmunoTherapy Corporation, a California corporation (the "Representative").


                                      Recitals:

     WHEREAS, the Company, the ImmunoTherapy Corporation shareholders and the
Representative have entered into a Warrant Agreement of even date herewith (the
"Warrant Agreement"), which sets forth the terms and conditions of certain
warrants to purchase the Company's Common Stock (the "Warrants") which have been
issued by the Company to such ImmunoTherapy Corporation shareholders in
connection with the merger of ImmunoTherapy with and into a wholly-owned
subsidiary of AntiVirals, pursuant to an Agreement and Plan of Reorganization
and Merger dated as of February 2, 1998, among the Company, AntiVirals
Acquisition Corporation and ImmunoTherapy Corporation, as amended (the
"Merger");

     WHEREAS, the Company and the Representative desire to amend the Warrant
Agreement to retain the Warrant Agent to act on behalf of the Company, and the
Warrant Agent is willing so to act, in connection with the issuance, transfer,
exchange and replacement of the certificates evidencing the Warrants to be
issued under this Agreement (the "Warrant Certificates") and the exercise of the
Warrants; and

     WHEREAS, the Company, the Warrant Agent and the Representative wish to
amend and restate the Warrant Agreement to modify the terms and conditions of
the Warrants and the rights of the holders thereof ("Warrantholders") and to set
forth the respective rights and obligations of the Company and the Warrant
Agent, with each Warrantholder as an intended beneficiary of this Agreement with
respect to the rights of Warrantholders herein;

          NOW, THEREFORE, in consideration of the premises and the mutual
agreements herein set forth, the parties hereto agree as follows:


Section 1.     APPOINTMENT OF WARRANT AGENT

               The Company appoints the Warrant Agent to act as agent for the
Company in accordance with the instructions in this Agreement and the Warrant
Agent accepts such appointment.


Section 2.     DATE, DENOMINATION AND EXECUTION OF WARRANT CERTIFICATES

               The Warrant Certificates (and the Form of Election to Purchase
and the Form of Assignment to be printed on the reverse thereof) shall be in
registered form only and shall be substantially of the tenor and purport recited
in Exhibit A hereto, and

                                       2
<PAGE>

may have such letters, numbers or other marks of identification or 
designation and such legends, summaries or endorsements printed, lithographed 
or engraved thereon as the Company may deem appropriate and as are not 
inconsistent with the provisions of this Agreement, or as may be required to 
comply with any law, or with any rule or regulation made pursuant thereto, or 
with any rule or regulation of any stock exchange on which the Common Stock 
or the Warrants may be listed or any automated quotation system, or to 
conform to usage.  Each Warrant Certificate shall entitle the registered 
holder thereof, subject to the provisions of this Agreement and of the 
Warrant Certificate, to purchase, after September 15, 2000 (the "Initial 
Exercise Date"), but prior to the close of business on May 15, 2003 (the 
"Expiration Date"), one fully paid and non-assessable share of Common Stock 
for each Warrant evidenced by such Warrant Certificate, subject to 
adjustments as provided in Section 6 hereof, for $13.50 (the "Exercise 
Price").  Each Warrant Certificate issued in connection with the Merger shall 
be dated September 15, 1998; each other Warrant Certificate shall be dated 
the date on which the Warrant Agent receives valid issuance instructions from 
the Company or a transferring holder of a Warrant Certificate or, if such 
instructions specify another date, such other date.

               For purposes of this Agreement, the term "close of business" on
any given date shall mean 5:00 p.m., Pacific Time, on such date; provided,
however, that if such date is not a business day, it shall mean 5:00 p.m.,
Pacific Time, on the next succeeding business day.  For purposes of this
Agreement, the term "business day" shall mean any day other than a Saturday,
Sunday, or a day on which banking institutions in New York are authorized or
obligated by law to be closed.

               Each Warrant Certificate shall be executed on behalf of the
Company by the Chairman of the Board or its President or a Vice President,
either manually or by facsimile signature printed thereon, and have affixed
thereto the Company's seal or a facsimile thereof which shall be attested by the
Secretary or an Assistant Secretary of the Company, either manually or by
facsimile signature.  Each Warrant Certificate shall be manually countersigned
by the Warrant Agent and shall not be valid for any purpose unless so
countersigned.  In case any officer of the Company who shall have signed any
Warrant Certificate shall cease to be such officer of the Company before
countersignature by the Warrant Agent and issue and delivery thereof by the
Company, such Warrant Certificate, nevertheless, may be countersigned by the
Warrant Agent, issued and delivered with the same force and effect as though the
person who signed such Warrant Certificate had not ceased to be such officer of
the Company.


Section 3.     SUBSEQUENT ISSUE OF WARRANT CERTIFICATES

               Subsequent to their original issuance, no Warrant Certificates
shall be reissued except (i) Warrant Certificates issued upon transfer thereof
in accordance with Section 4 hereof, (ii) Warrant Certificates issued upon any
combination, split-up or exchange of Warrant Certificates pursuant to Section 4
hereof, (iii) Warrant Certificates issued in replacement of mutilated,
destroyed, lost or stolen Warrant Certificates pursuant to Section 5 hereof,
(iv) Warrant Certificates issued upon the partial exercise of Warrant
Certificates pursuant to Section 7 hereof, and (v) Warrant Certificates issued

                                       3
<PAGE>

to reflect any adjustment or change in the Exercise Price or the number or kind
of shares purchasable thereunder pursuant to Section 22 hereof.  The Warrant
Agent is hereby irrevocably authorized to countersign and deliver, in accordance
with the provisions of said Sections 4, 5, 7 and 22, the new Warrant
Certificates required for purposes thereof, and the Company, whenever required
by the Warrant Agent, will supply the Warrant Agent with Warrant Certificates
duly executed on behalf of the Company for such purposes.


Section 4.     TRANSFERS AND EXCHANGES OF WARRANT CERTIFICATES

               The Warrant Agent will keep or cause to be kept books for
registration of ownership and transfer of the Warrant Certificates issued
hereunder.  Such registers shall show the names and addresses of the respective
holders of the Warrant Certificates and the number of Warrants evidenced by each
such Warrant Certificate.

               The Warrant Agent shall, from time to time, register the transfer
of any outstanding Warrants upon the books to be maintained by the Warrant Agent
for that purpose, upon surrender of the Warrant Certificate evidencing such
Warrants, with the Form of Assignment duly filled in and executed with such
signature guaranteed by a banking institution or NASD member and such supporting
documentation as the Warrant Agent or the Company may reasonably require, to the
Warrant Agent at its stock transfer office in Ridgefield Park, New Jersey at any
time on or before the Expiration Date, and upon payment to the Warrant Agent for
the account of the Company of an amount equal to any applicable transfer tax. 
Payment of the amount of such tax may be made in cash, or by certified or
official bank check, payable in lawful money of the United States of America to
the order of the Company.

               Upon receipt of a Warrant Certificate, with the Form of
Assignment duly filled in and executed, accompanied by payment of an amount
equal to any applicable transfer tax, the Warrant Agent shall promptly cancel
the surrendered Warrant Certificate and countersign and deliver to the
transferee a new Warrant Certificate for the number of full Warrants transferred
to such transferee; PROVIDED, HOWEVER, that in case the registered holder of any
Warrant Certificate shall elect to transfer fewer than all of the Warrants
evidenced by such Warrant Certificate, the Warrant Agent in addition shall
promptly countersign and deliver to such registered holder a new Warrant
Certificate or Certificates for the number of full Warrants not so transferred.

               Any Warrant Certificate or Certificates may be exchanged at the
option of the holder thereof for another Warrant Certificate or Certificates of
different denominations, of like tenor and representing in the aggregate the
same number of Warrants, upon surrender of such Warrant Certificate or
Certificates, with the Form of Assignment duly filled in and executed, to the
Warrant Agent, at any time or from time to time after the close of business on
the date hereof and prior to the close of business on the Expiration Date.  The
Warrant Agent shall promptly cancel the surrendered Warrant Certificate and
deliver the new Warrant Certificate pursuant to the provisions of this Section.

                                       4
<PAGE>

Section 5.     MUTILATED, DESTROYED, LOST OR STOLEN WARRANT CERTIFICATES

               Upon receipt by the Company and the Warrant Agent of evidence
reasonably satisfactory to them of the loss, theft, destruction or mutilation of
any Warrant Certificate, and in the case of loss, theft or destruction, of
indemnity or security reasonably satisfactory to them, and reimbursement to them
of all reasonable expenses incidental thereto, and, in the case of mutilation,
upon surrender and cancellation of the Warrant Certificate, the Warrant Agent
shall countersign and deliver a new Warrant Certificate of like tenor for the
same number of Warrants.


Section 6.     ADJUSTMENTS OF NUMBER AND KIND OF SHARES PURCHASABLE AND EXERCISE
PRICE
     
               The number and kind of securities or other property purchasable
upon exercise of a Warrant shall be subject to adjustment from time to time upon
the occurrence, after the date hereof, of any of the following events:

          A.   In case the Company shall (1) pay a dividend in, or make a
distribution of, shares of capital stock on its outstanding Common Stock,
(2) subdivide its outstanding shares of Common Stock into a greater number of
such shares or (3) combine its outstanding shares of Common Stock into a smaller
number of such shares, the total number of shares of Common Stock purchasable
upon the exercise of each Warrant outstanding immediately prior thereto shall be
adjusted so that the holder of any Warrant Certificate thereafter surrendered
for exercise shall be entitled to receive at the same aggregate Exercise Price
the number of shares of capital stock (of one or more classes) which such holder
would have owned or have been entitled to receive immediately following the
happening of any of the events described above had such Warrant been exercised
in full immediately prior to the record date with respect to such event.  Any
adjustment made pursuant to this Subsection shall, in the case of a stock
dividend or distribution, become effective as of the record date therefor and,
in the case of a subdivision or combination, be made as of the effective date
thereof.  If, as a result of an adjustment made pursuant to this Subsection, the
holder of any Warrant Certificate thereafter surrendered for exercise shall
become entitled to receive shares of two or more classes of capital stock of the
Company, the Board of Directors of the Company (whose determination shall be
conclusive and shall be evidenced by a Board resolution filed with the Warrant
Agent) shall determine the allocation of the adjusted Exercise Price between or
among shares of such classes of capital stock.

          B.   In the event of a capital reorganization or a reclassification of
the Common Stock (except as provided in Subsection A. above or Subsection E.
below), any Warrantholder, upon exercise of Warrants, shall be entitled to
receive, in substitution for the Common Stock to which he would have become
entitled upon exercise immediately prior to such reorganization or
reclassification, the shares (of any class or classes) or other securities or
property of the Company (or cash) that he would have been entitled to receive at
the same aggregate Exercise Price upon such reorganization or reclassification
if such Warrants had been exercised immediately prior

                                       5
<PAGE>

to the record date with respect to such event; and in any such case, 
appropriate provision (as determined by the Board of Directors of the 
Company, whose determination shall be conclusive and shall be evidenced by a 
certified Board resolution filed with the Warrant Agent) shall be made for 
the application of this Section 6 with respect to the rights and interests 
thereafter of the Warrantholders (including but not limited to the allocation 
of the Exercise Price between or among shares of classes of capital stock), 
to the end that this Section 6 (including the adjustments of the number of 
shares of Common Stock or other securities purchasable and the Exercise Price 
thereof) shall thereafter be reflected, as nearly as reasonably practicable, 
in all subsequent exercises of the Warrants for any shares or securities or 
other property (or cash) thereafter deliverable upon the exercise of the 
Warrants.

          C.   Whenever the number of shares of Common Stock or other securities
purchasable upon exercise of a Warrant is adjusted as provided in this
Section 6, the Company will promptly file with the Warrant Agent a certificate
signed by a Chairman or co-Chairman of the Board or the President or a Vice
President of the Company and by the Treasurer or an Assistant Treasurer or the
Secretary or an Assistant Secretary of the Company setting forth the number and
kind of securities or other property purchasable upon exercise of a Warrant, as
so adjusted, stating that such adjustments in the number or kind of shares or
other securities or property conform to the requirements of this Section 6, and
setting forth a brief statement of the facts accounting for such adjustments. 
Promptly after receipt of such certificate, the Company, or the Warrant Agent at
the Company's request, will deliver, by first-class, postage prepaid mail, a
brief summary thereof (to be supplied by the Company) to the registered holders
of the outstanding Warrant Certificates; PROVIDED, HOWEVER, that failure to file
or to give any notice required under this Subsection, or any defect therein,
shall not affect the legality or validity of any such adjustments under this
Section 6; and PROVIDED, FURTHER, that, where appropriate, such notice may be
given in advance and included as part of the notice required to be given
pursuant to Section 12 hereof.

          D.   In case of any consolidation of the Company with, or merger of
the Company into, another corporation (other than a consolidation or merger
which does not result in any reclassification or change of the outstanding
Common Stock), or in case of any sale or conveyance to another corporation of
the property of the Company as an entirety or substantially as an entirety, the
corporation formed by such consolidation or merger or the corporation which
shall have acquired such assets, as the case may be, shall execute and deliver
to the Warrant Agent a supplemental warrant agreement providing that the holder
of each Warrant then outstanding shall have the right thereafter (until the
expiration of such Warrant) to receive, upon exercise of such Warrant, solely
the kind and amount of shares of stock and other securities and property (or
cash) receivable upon such consolidation, merger, sale or transfer by a holder
of the number of shares of Common Stock of the Company for which such Warrant
might have been exercised immediately prior to such consolidation, merger, sale
or transfer.  Such supplemental warrant agreement shall provide for adjustments
which shall be as nearly equivalent as may be practicable to the adjustments
provided in this Section.  The above provision of this Subsection shall
similarly apply to successive consolidations, mergers, sales or transfers.

                                       6
<PAGE>

               The Warrant Agent shall not be under any responsibility to
determine the correctness of any provision contained in any such supplemental
warrant agreement relating to either the kind or amount of shares of stock or
securities or property (or cash) purchasable by holders of Warrant Certificates
upon the exercise of their Warrants after any such consolidation, merger, sale
or transfer or of any adjustment to be made with respect thereto, but subject to
the provisions of Section 20 hereof, may accept as conclusive evidence of the
correctness of any such provisions, and shall be protected in relying upon, a
certificate of a firm of independent certified public accountants (who may be
the accountants regularly employed by the Company) with respect thereto.

          E.   Irrespective of any adjustments in the number or kind of shares
issuable upon exercise of Warrants, Warrant Certificates theretofore or
thereafter issued may continue to express the same price and number and kind of
shares as are stated in the similar Warrant Certificates initially issuable
pursuant to this Warrant Agreement.

          F.   The Company may retain a firm of independent public accountants
of recognized standing, which may be the firm regularly retained by the Company,
selected by the Board of Directors of the Company or the Executive Committee of
said Board, and not disapproved by the Warrant Agent, to make any computation
required under this Section, and a certificate signed by such firm shall, in the
absence of fraud or gross negligence, be conclusive evidence of the correctness
of any computation made under this Section.

          G.   For the purpose of this Section, the term "Common Stock" shall
mean (i) the class of stock designated as Common Stock in the Articles of
Incorporation of the Company, as amended, at the date of this Agreement, or
(ii) any other class of stock resulting from successive changes or
reclassification of such Common Stock consisting solely of changes in par value,
or from par value to no par value, or from no par value to par value.  In the
event that at any time as a result of an adjustment made pursuant to this
Section, the holder of any Warrant thereafter surrendered for exercise shall
become entitled to receive any shares of capital stock of the Company other than
shares of Common Stock, thereafter the number of such other shares so receivable
upon exercise of any Warrant shall be subject to adjustment from time to time in
a manner and on terms as nearly equivalent as practicable to the provisions with
respect to the Common Stock contained in this Section, and all other provisions
of this Agreement, with respect to the Common Stock, shall apply on like terms
to any such other shares.

          H.   The Company may, from time to time and to the extent permitted by
law, reduce the exercise price of the Warrants by any amount for a period of not
less than 20 days.  If the Company so reduces the exercise price of the
Warrants, it will give not less than 15 days' notice of such decrease, which
notice may be in the form of a press release, and shall take such other steps as
may be required under applicable law in connection with any offers or sales of
securities at the reduced price.


Section 7.     EXERCISE AND REDEMPTION OF WARRANTS

                                       7
<PAGE>

               Unless the Warrants have been redeemed as provided in this
Section 7, the registered holder of any Warrant Certificate may exercise the
Warrants evidenced thereby, in whole at any time or in part from time to time
after the Initial Exercise Date but prior to the close of business, on the
Expiration Date, subject to the provisions of Section 9, at which time the
Warrant Certificates shall be and become wholly void and of no value.  Warrants
may be exercised by their holders or redeemed by the Company as follows:

          A.   Exercise of Warrants shall be accomplished upon surrender of the
Warrant Certificate evidencing such Warrants, with the Form of Election to
Purchase on the reverse side thereof duly filled in and executed, to the Warrant
Agent at its stock transfer office in Ridgefield Park, New Jersey, together with
payment to the Company of the Exercise Price (as of the date of such surrender)
of the Warrants then being exercised and an amount equal to any applicable
transfer tax and, if requested by the Company, any other taxes or governmental
charges which the Company may be required by law to collect in respect of such
exercise.  Payment of the Exercise Price and other amounts may be made by wire
transfer of good funds, or by certified or bank cashier's check, payable in
lawful money of the United States of America to the order of the Company.  No
adjustment shall be made for any cash dividends, whether paid or declared, on
any securities issuable upon exercise of a Warrant.

          B.   Upon receipt of a Warrant Certificate, with the Form of Election
to Purchase duly filled in and executed, accompanied by payment of the Exercise
Price of the Warrants being exercised (and of an amount equal to any applicable
taxes or government charges as aforesaid), the Warrant Agent shall promptly
request from the Transfer Agent with respect to the securities to be issued and
deliver to or upon the order of the registered holder of such Warrant
Certificate, in such name or names as such registered holder may designate, a
certificate or certificates for the number of full shares of the securities to
be purchased, together with cash made available by the Company pursuant to
Section 8 hereof in respect of any fraction of a share of such securities
otherwise issuable upon such exercise.  If the Warrant is then exercisable to
purchase property other than securities, the Warrant Agent shall take
appropriate steps to cause such property to be delivered to or upon the order of
the registered holder of such Warrant Certificate.  In addition, if it is
required by law and upon instruction by the Company, the Warrant Agent will
deliver to each Warrantholder a prospectus which complies with the provisions of
Section 9 of the Securities Act of 1933, as amended, and the Company agrees to
supply Warrant Agent with sufficient number of prospectuses to effectuate that
purpose.

          C.   In case the registered holder of any Warrant Certificate shall
exercise fewer than all of the Warrants evidenced by such Warrant Certificate,
the Warrant Agent shall promptly countersign and deliver to the registered
holder of such Warrant Certificate, or to his duly authorized assigns, a new
Warrant Certificate or Certificates evidencing the number of Warrants that were
not so exercised.

          D.   Each person in whose name any certificate for securities is
issued upon the exercise of Warrants shall for all purposes be deemed to have
become the holder of record of the securities represented thereby as of, and
such certificate shall be

                                       8
<PAGE>

dated, the date upon which the Warrant Certificate was duly surrendered in 
proper form and payment of the Exercise Price (and of any applicable taxes or 
other governmental charges) was made; PROVIDED, HOWEVER, that if the date of 
such surrender and payment is a date on which the stock transfer books of the 
Company are closed, such person shall be deemed to have become the record 
holder of such shares as of, and the certificate for such shares shall be 
dated, the next succeeding business day on which the stock transfer books of 
the Company are open (whether before, on or after the Expiration Date) and 
the Warrant Agent shall be under no duty to deliver the certificate for such 
shares until such date.  The Company covenants and agrees that it shall not 
cause its stock transfer books to be closed for a period of more than 20 
consecutive business days except upon consolidation, merger, sale of all or 
substantially all of its assets, dissolution or liquidation or as otherwise 
provided by law.

          E.   The Warrants outstanding at the time of a redemption may be
redeemed at the option of the Company, in whole or in part on a pro rata basis,
at any time if, at the time notice of such redemption is given by the Company as
provided in Paragraph F, below, the Daily Price has exceeded $27.00 for the
20 consecutive trading days immediately preceding the date of such notice, at a
price equal to $0.25 per Warrant (the "Redemption Price").  The 20-day trading
period described in the preceding sentence must occur after the Initial Exercise
Date and while the shares subject to the Warrants are covered by an effective
Registration Statement under the Securities Act of 1933, as amended.  For the
purpose of the foregoing sentence, the term "Daily Price" shall mean, for any
relevant day, the closing bid price on that day as reported by the principal
exchange or quotation system on which prices for the Common Stock are reported. 
On the redemption date the holders of record of redeemed Warrants shall be
entitled to payment of the Redemption Price upon surrender of such redeemed
Warrants to the Company at the principal office of the Warrant Agent in
Ridgefield Park, New Jersey.

          F.   Notice of redemption of Warrants shall be given at least 30 days
prior to the redemption date by mailing, by registered or certified mail, return
receipt requested, a copy of such notice to the Warrant Agent and to all of the
holders of record of Warrants at their respective addresses appearing on the
books or transfer records of the Company or such other address designated in
writing by the holder of record to the Warrant Agent not less than 40 days prior
to the redemption date.

          G.   From and after the redemption date, all rights of the
Warrantholders (except the right to receive the Redemption Price) shall
terminate, but only if (a) no later than one day prior to the redemption date
the Company shall have irrevocably deposited with the Warrant Agent as paying
agent a sufficient amount to pay on the redemption date the Redemption Price for
all Warrants called for redemption and (b) the notice of redemption shall have
stated the name and address of the Warrant Agent and the intention of the
Company to deposit such amount with the Warrant Agent no later than one day
prior to the redemption date.

          H.   The Warrant Agent shall pay to the holders of record of redeemed
Warrants all monies received by the Warrant Agent for the redemption of Warrants
to which the holders of record of such redeemed Warrants who shall have
surrendered

                                       9
<PAGE>

their Warrants are entitled.

          I.   Any amounts deposited with the Warrant Agent that are not
required for redemption of Warrants may be withdrawn by the Company.  Any
amounts deposited with the Warrant Agent that shall be unclaimed after six
months after the redemption date may be withdrawn by the Company, and thereafter
the holders of the Warrants called for redemption for which such funds were
deposited shall look solely to the Company for payment.  The Company shall be
entitled to the interest, if any, on funds deposited with the Warrant Agent and
the holders of redeemed Warrants shall have no right to any such interest.

          J.   If the Company fails to make a sufficient deposit with the
Warrant Agent as provided above, the holder of any Warrants called for
redemption may at the option of the holder (a) by notice to the Company declare
the notice of redemption a nullity as to such holder, or (b) maintain an action
against the Company for the Redemption Price.  If the holder brings such an
action, the Company will pay reasonable attorneys' fees of the holder.  If the
holder fails to bring an action against the Company for the Redemption Price
within 60 days after the redemption date, the holder shall be deemed to have
elected to declare the notice of redemption to be a nullity as to such holder
and such notice shall be without any force or effect as to such holder.  Except
as otherwise specifically provided in this Paragraph J, a notice of redemption,
once mailed by the Company as provided in Paragraph F shall be irrevocable.


Section 8.     FRACTIONAL INTERESTS

               The Company shall not be required to issue any Warrant
Certificate evidencing a fraction of a Warrant or to issue fractions of shares
of securities on the exercise of the Warrants.  If any fraction (calculated to
the nearest one-hundredth) of a Warrant or a share of securities would, except
for the provisions of this Section, be issuable on the exercise of any Warrant,
the Company shall, at its option, either purchase such fraction for an amount in
cash equal to the current value of such fraction computed on the basis of the
closing market price (as quoted on NASDAQ) on the trading day immediately
preceding the day upon which such Warrant Certificate was surrendered for
exercise in accordance with Section 7 hereof or issue the required fractional
Warrant or share.  By accepting a Warrant Certificate, the holder thereof
expressly waives any right to receive a Warrant Certificate evidencing any
fraction of a Warrant or to receive any fractional share of securities upon
exercise of a Warrant, except as expressly provided in this Section 8.


Section 9.     RESERVATION OF EQUITY SECURITIES

               The Company covenants that it will at all times reserve and keep
available, free from any pre-emptive rights, out of its authorized and unissued
equity securities, solely for the purpose of issue upon exercise of the
Warrants, such number of shares of equity securities of the Company as shall
then be issuable upon the exercise of all outstanding Warrants ("Equity
Securities").  The Company covenants

                                       10
<PAGE>

that all Equity Securities which shall be so issuable shall, upon such issue, 
be duly authorized, validly issued, fully paid and non-assessable.

               The Company covenants that it will use all commercially
reasonable efforts to cause the Equity Securities to be duly registered, or
approved, as the case may be, and, to the extent practicable, take all such
action in anticipation of and prior to the exercise of the Warrants, including,
without limitation, filing any Registration Statement necessary to permit the
public offering of the securities underlying the Warrants at any and all times
during the term of this Agreement, PROVIDED, HOWEVER, that in no event shall
such securities be issued, and the Company is authorized to refuse to honor the
exercise of any Warrant, if such exercise would result in the opinion of the
Company's Board of Directors, upon advice of counsel, in the violation of any
law.  The Company will use all commercially reasonable efforts to cause the
Equity Securities to be quoted for trading on the NASDAQ/NMS.  The Company will
use all commercially reasonable efforts to cause the Warrants to be quoted for
trading on the NASDAQ/NMS or such other exchange as shall be mutually acceptable
to the Company and the holders of a majority of the Warrants on or before the
Initial Exercise Date.


Section 10.    REDUCTION OF CONVERSION PRICE BELOW PAR VALUE

               Before taking any action that would cause an adjustment pursuant
to Section 6 hereof reducing the portion of the Exercise Price required to
purchase one share of capital stock below the then par value (if any) of a share
of such capital stock, the Company will use its best efforts to take any
corporate action which, in the opinion of its counsel, may be necessary in order
that the Company may validly and legally issue fully paid and non-assessable
shares of such capital stock.


Section 11.    PAYMENT OF TAXES

               The Company covenants and agrees that it will pay when due and
payable any and all federal and state documentary stamp and other original issue
taxes which may be payable in respect of the original issuance of the Warrant
Certificates, or any shares of Common Stock or other securities upon the
exercise of Warrants.  The Company shall not, however, be required (i) to pay
any tax which may be payable in respect of any transfer involved in the transfer
and delivery of Warrant Certificates or the issuance or delivery of certificates
for Common Stock or other securities in a name other than that of the registered
holder of the Warrant Certificate surrendered for purchase or (ii) to issue or
deliver any certificate for shares of Common Stock or other securities upon the
exercise of any Warrant Certificate until any such tax shall have been paid, all
such tax being payable by the holder of such Warrant Certificate at the time of
surrender.


Section 12.    NOTICE OF CERTAIN CORPORATE ACTION

                                       11
<PAGE>

               In case the Company after the date hereof shall propose (i) to
offer to the holders of Common Stock, generally, rights to subscribe to or
purchase any additional shares of any class of its capital stock, any evidences
of its indebtedness or assets, or any other rights or options or (ii) to effect
any reclassification of Common Stock (other than a reclassification involving
merely the subdivision or combination of outstanding shares of Common Stock) or
any capital reorganization, or any consolidation or merger to which the Company
is a party and for which approval of any stockholders of the Company is
required, or any sale, transfer or other disposition of its property and assets
substantially as an entirety, or the liquidation, voluntary or involuntary
dissolution or winding-up of the Company, then, in each such case, the Company
shall file with the Warrant Agent and the Company, or the Warrant Agent on its
behalf, shall mail (by first-class, postage prepaid mail) to all registered
holders of the Warrant Certificates notice of such proposed action, which notice
shall specify the date on which the books of the Company shall close or a record
be taken for such offer of rights or options, or the date on which such
reclassification, reorganization, consolidation, merger, sale, transfer, other
disposition, liquidation, voluntary or involuntary dissolution or winding-up
shall take place or commence, as the case may be, and which shall also specify
any record date for determination of holders of Common Stock entitled to vote
thereon or participate therein and shall set forth such facts with respect
thereto as shall be reasonably necessary to indicate any adjustments in the
Exercise Price and the number or kind of shares or other securities purchasable
upon exercise of Warrants which will be required as a result of such action. 
Such notice shall be filed and mailed in the case of any action covered by
clause (i) above, at least 10 days prior to the record date for determining
holders of the Common Stock for purposes of such action or, if a record is not
to be taken, the date as of which the holders of shares of Common Stock of
record are to be entitled to such offering; and, in the case of any action
covered by clause (ii) above, at least 20 days prior to the earlier of the date
on which such reclassification, reorganization, consolidation, merger, sale,
transfer, other disposition, liquidation, voluntary or involuntary dissolution
or winding-up is expected to become effective and the date on which it is
expected that holders of shares of Common Stock of record on such date shall be
entitled to exchange their shares for securities or other property deliverable
upon such reclassification, reorganization, consolidation, merger, sale,
transfer, other disposition, liquidation, voluntary or involuntary dissolution
or winding-up.

               Failure to give any such notice or any defect therein shall not
affect the legality or validity of any transaction listed in this Section 12.


Section 13.    DISPOSITION OF PROCEEDS ON EXERCISE OF WARRANT CERTIFICATES, ETC.

               The Warrant Agent shall account promptly to the Company with
respect to Warrants exercised and concurrently pay to the Company all moneys
received by the Warrant Agent for the purchase of securities or other property
through the exercise of such Warrants.

               The Warrant Agent shall keep copies of this Agreement available
for inspection by Warrantholders during normal business hours at its stock
transfer office.  Copies of this Agreement may be obtained upon written request
addressed to

                                       12
<PAGE>

the Warrant Agent at its stock transfer office in Ridgefield Park, New Jersey.


Section 14.  WARRANTHOLDER NOT DEEMED A STOCKHOLDER

               No Warrantholder, as such, shall be entitled to vote, receive
dividends or be deemed the holder of Common Stock or any other securities of the
Company which may at any time be issuable on the exercise of the Warrants
represented thereby for any purpose whatever, nor shall anything contained
herein or in any Warrant Certificate be construed to confer upon any
Warrantholder, as such, any of the rights of a stockholder of the Company or any
right to vote for the election of directors or upon any matter submitted to
stockholders at any meeting thereof, or to give or withhold consent to any
corporate action (whether upon any recapitalization, issuance of stock,
reclassification of stock, change of par value or change of stock to no par
value, consolidation, merger, conveyance or otherwise), or to receive notice of
meetings or other actions affecting stockholders (except as provided in
Section 12 hereof), or to receive dividend or subscription rights, or otherwise,
until such Warrant Certificate shall have been exercised in accordance with the
provisions hereof and the receipt of the Exercise Price and any other amounts
payable upon such exercise by the Warrant Agent.


Section 15.    RIGHT OF ACTION

               All rights of action in respect to this Agreement are vested in
the respective registered holders of the Warrant Certificates; and any
registered holder of any Warrant Certificate, without the consent of the Warrant
Agent or of any other holder of a Warrant Certificate, may, in his own behalf
for his own benefit, enforce, and may institute and maintain any suit, action or
proceeding against the Company suitable to enforce, or otherwise in respect of,
his right to exercise the Warrants evidenced by such Warrant Certificate, for
the purchase of shares of the Common Stock in the manner provided in the Warrant
Certificate and in this Agreement.


Section 16.    AGREEMENT OF HOLDERS OF WARRANT CERTIFICATES

               Every holder of a Warrant Certificate by accepting the same
consents and agrees with the Company, the Warrant Agent and with every other
holder of a Warrant Certificate that:

          A.   The Warrant Certificates are transferable on the registry books
of the Warrant Agent only upon the terms and conditions set forth in this
Agreement; and

          B.   The Company and the Warrant Agent may deem and treat the person
in whose name the Warrant Certificate is registered as the absolute owner of the
Warrant (notwithstanding any notation of ownership or other writing thereon made
by anyone other than the Company or the Warrant Agent) for all purposes whatever
and neither the Company nor the Warrant Agent shall be affected by any notice to
the contrary.

                                       13
<PAGE>

Section 17.    CANCELLATION OF WARRANT CERTIFICATES

               In the event that the Company shall purchase or otherwise acquire
any Warrant Certificate or Certificates after the issuance thereof, such Warrant
Certificate or Certificates shall thereupon be delivered to the Warrant Agent
and be canceled by it and retired.  The Warrant Agent shall also cancel any
Warrant Certificate delivered to it for exercise, in whole or in part, or
delivered to it for transfer, split-up, combination or exchange.  Warrant
Certificates so canceled shall be delivered by the Warrant Agent to the Company
from time to time, or disposed of in accordance with the instructions of the
Company.


Section 18.    CONCERNING THE WARRANT AGENT

               The Company agrees to pay to the Warrant Agent from time to time,
on demand of the Warrant Agent, reasonable compensation for all services
rendered by it hereunder and also its reasonable expenses, including counsel
fees, and other disbursements incurred in the administration and execution of
this Agreement and the exercise and performance of its duties hereunder.  The
Company also agrees to indemnify the Warrant Agent for, and to hold it harmless
against, any loss, liability or expense, incurred without gross negligence, bad
faith or willful misconduct on the part of the Warrant Agent, arising out of or
in connection with the acceptance and administration of this Agreement.  In no
case shall the Warrant Agent be liable for special, indirect, incidental or
consequential loss or damage, even if the Warrant Agent has been advised of the
likelihood of such loss or damage.


Section 19.    MERGER OR CONSOLIDATION OR CHANGE OF NAME OF WARRANT AGENT

               Any corporation into which the Warrant Agent may be merged or
with which it may be consolidated, or any corporation resulting from any merger
or consolidation to which the Warrant Agent shall be a party, or any corporation
succeeding to the corporate trust business of the Warrant Agent, shall be the
successor to the Warrant Agent hereunder without the execution or filing of any
paper or any further act on the part of any of the parties hereto, provided that
such corporation would be eligible for appointment as a successor warrant agent
under the provisions of Section 21 hereof.  In case at the time such successor
to the Warrant Agent shall succeed to the agency created by this Agreement, any
of the Warrant Certificates shall have been countersigned but not delivered, any
such successor to the Warrant Agent may adopt the countersignature of the
original Warrant Agent and deliver such Warrant Certificates so countersigned;
and in case at that time any of the Warrant Certificates shall not have been
countersigned, any successor to the Warrant Agent may countersign such Warrant
Certificates either in the name of the predecessor Warrant Agent or in the name
of the successor Warrant Agent; and in all such cases such Warrant Certificates
shall have the full force provided in the Warrant Certificates and in this
Agreement.

                                       14
<PAGE>

               In case at any time the name of the Warrant Agent shall be
changed and at such time any of the Warrant Certificates shall have been
countersigned but not delivered, the Warrant Agent may adopt the
countersignature under its prior name and deliver Warrant Certificates so
countersigned; and in case at that time any of the Warrant Certificates shall
not have been countersigned, the Warrant Agent may countersign such Warrant
Certificates either in its prior name or in its changed name; and in all such
cases such Warrant Certificates shall have the full force provided in the
Warrant Certificates and in this Agreement.


Section 20.    DUTIES OF WARRANT AGENT

               The Warrant Agent undertakes the duties and obligations imposed
by this Agreement upon the following terms and conditions, by all of which the
Company and the holders of Warrant Certificates, by their acceptance thereof,
shall be bound:

          A.   The Warrant Agent may consult with counsel satisfactory to it
(who may be counsel for the Company or the Warrant Agent's in-house counsel),
and the opinion of such counsel shall be full and complete authorization and
protection to the Warrant Agent as to any action taken, suffered or omitted by
it in good faith and in accordance with such opinion; PROVIDED, HOWEVER, that
the Warrant Agent shall have exercised reasonable care in the selection of such
counsel.  Fees and expenses of such counsel, to the extent reasonable, shall be
paid by the Company.

          B.   Whenever in the performance of its duties under this Agreement,
the Warrant Agent shall deem it necessary or desirable that any fact or matter
be proved or established by the Company prior to taking or suffering any action
hereunder, such fact or matter (unless other evidence in respect thereof be
herein specifically prescribed) may be deemed to be conclusively proved and
established by a certificate signed by a Chairman or co-Chairman of the Board or
the President or a Vice President or the Secretary of the Company and delivered
to the Warrant Agent; and such certificate shall be full authorization to the
Warrant Agent for any action taken or suffered in good faith by it under the
provisions of this Agreement in reliance upon such certificate.

          C.   The Warrant Agent shall be liable hereunder only for its own
gross negligence, bad faith or willful misconduct.

          D.   The Warrant Agent shall not be liable for or by reason of any of
the statements of fact or recitals contained in this Agreement or in the Warrant
Certificates (except its countersignature on the Warrant Certificates and such
statements or recitals as describe the Warrant Agent or action taken or to be
taken by it) or be required to verify the same, but all such statements and
recitals are and shall be deemed to have been made by the Company only.

          E.   The Warrant Agent shall not be under any responsibility in
respect of the validity of this Agreement or the execution and delivery hereof
(except the due execution hereof by the Warrant Agent) or in respect of the
validity or execution of any

                                       15
<PAGE>

Warrant Certificate (except its countersignature thereof); nor shall it be 
responsible for any breach by the Company of any covenant or condition 
contained in this Agreement or in any Warrant Certificate; nor shall it be 
responsible for the making of any change in the number of shares of Common 
Stock for which a Warrant is exercisable required under the provisions of 
Section 6 or responsible for the manner, method or amount of any such change 
or the ascertaining of the existence of facts that would require any such 
adjustment or change (except with respect to the exercise of Warrant 
Certificates after actual notice of any adjustment of the Exercise Price); 
nor shall it by any act hereunder be deemed to make any representation or 
warranty as to the authorization or reservation of any shares of Common Stock 
to be issued pursuant to this Agreement or any Warrant Certificate or as to 
whether any shares of Common Stock will, when issued, be validly issued, 
fully paid and non-assessable.

          F.   The Warrant Agent shall be under no obligation to institute any
action, suit or legal proceeding or take any other action likely to involve
expense unless the Company or one or more registered holders of Warrant
Certificates shall furnish the Warrant Agent with reasonable security and
indemnity for any costs and expenses which may be incurred.  All rights of
action under this Agreement or under any of the Warrants may be enforced by the
Warrant Agent without the possession of any of the Warrants or the production
thereof at any trial or other proceeding relative thereto, and any such action,
suit or proceeding instituted by the Warrant Agent shall be brought in its name
as Warrant Agent, and any recovery of judgment shall be for the ratable benefit
of the registered holders of the Warrant Certificates, as their respective
rights or interests may appear.

          G.   The Warrant Agent and any stockholder, director, officer or
employee of the Warrant Agent may buy, sell or deal in any of the Warrants or
other securities of the Company or become pecuniarily interested in any
transaction in which the Company may be interested, or contract with or lend
money to or otherwise act as fully and freely as though it were not Warrant
Agent under this Agreement.  Nothing herein shall preclude the Warrant Agent
from acting in any other capacity for the Company or for any other legal entity.

          H.   The Warrant Agent is hereby authorized and directed to accept
instructions with respect to the performance of its duties hereunder from a
Chairman or co-Chairman of the Board or President or a Vice President or the
Secretary or the Controller of the Company, and to apply to such officers for
advice or instructions in connection with the Warrant Agent's duties, and it
shall not be liable for any action taken or suffered or omitted by it in good
faith in accordance with instructions of any such officer.

          I.   The Warrant Agent will not be responsible for any failure of the
Company to comply with any of the covenants contained in this Agreement or in
the Warrant Certificates to be complied with by the Company.

          J.   The Warrant Agent may execute and exercise any of the rights or
powers hereby vested in it or perform any duty hereunder either itself or by or
through its attorneys, agents or employees and the Warrant Agent shall not be
answerable or

                                       16
<PAGE>

accountable for any act, default, neglect or misconduct of any such 
attorneys, agents or employees or for any loss to the Company resulting from 
such neglect or misconduct; PROVIDED, HOWEVER, that reasonable care shall 
have been exercised in the selection and continued employment of such 
attorneys, agents and employees.

          K.   The Warrant Agent will not incur any liability or responsibility
to the Company or to any holder of any Warrant Certificate for any action taken,
or any failure to take action, in reliance on any notice, resolution, waiver,
consent, order, certificate, or other paper, document or instrument reasonably
believed by the Warrant Agent to be genuine and to have been signed, sent or
presented by the proper party or parties.

          L.   The Warrant Agent will act hereunder solely as agent of the
Company in a ministerial capacity, and its duties will be determined solely by
the provisions hereof.  The Warrant Agent will not be liable for anything which
it may do or refrain from doing in connection with this Agreement except for its
own gross negligence, bad faith or willful conduct.


Section 21.    CHANGE OF WARRANT AGENT

               The Warrant Agent may resign and be discharged from its duties
under this Agreement upon 30 days' prior notice in writing mailed, by registered
or certified mail, to the Company.  The Company may remove the Warrant Agent or
any successor warrant agent upon 30 days' prior notice in writing, mailed to the
Warrant Agent or successor warrant agent, as the case may be, by registered or
certified mail.  If the Warrant Agent shall resign or be removed or shall
otherwise become incapable of acting, the Company shall appoint a successor to
the Warrant Agent and shall, within 15 days following such appointment, give
notice thereof in writing to each registered holder of the Warrant Certificates.
If the Company shall fail to make such appointment within a period of 15 days
after giving notice of such removal or after it has been notified in writing of
such resignation or incapacity by the resigning or incapacitated Warrant Agent,
then the Company agrees to perform the duties of the Warrant Agent hereunder
until a successor Warrant Agent is appointed.  After appointment and execution
of a copy of this Agreement in effect at that time, the successor Warrant Agent
shall be vested with the same powers, rights, duties and responsibilities as if
it had been originally named as Warrant Agent without further act or deed; but
the former Warrant Agent shall deliver and transfer to the successor Warrant
Agent, within a reasonable time, any property at the time held by it hereunder,
and execute and deliver any further assurance, conveyance, act or deed necessary
for the purpose.  Failure to give any notice provided for in this Section,
however, or any defect therein shall not affect the legality or validity of the
resignation or removal of the Warrant Agent or the appointment of the successor
warrant agent, as the case may be.


Section 22.    ISSUANCE OF NEW WARRANT CERTIFICATES

               Notwithstanding any of the provisions of this Agreement or the
several Warrant Certificates to the contrary, the Company may, at its option,
issue new Warrant

                                       17
<PAGE>

Certificates in such form as may be approved by its Board of Directors to 
reflect any adjustment or change in the Exercise Price or the number or kind 
of shares purchasable under the several Warrant Certificates made in 
accordance with the provisions of this Agreement.

Section 23.    NOTICES

               Notice or demand pursuant to this Agreement to be given or made
on the Company by the Warrant Agent or by the registered holder of any Warrant
Certificate shall be sufficiently given or made if sent by first-class or
registered mail, postage prepaid, addressed (until another address is filed in
writing by the Company with the Warrant Agent) as follows: 

                         AntiVirals Inc.
                         One S.W. Columbia, Suite 1105
                         Portland, Oregon    97258


               Subject to the provisions of Section 21, any notice pursuant to
this Agreement to be given or made by the Company or by the holder of any
Warrant Certificate to or on the Warrant Agent shall be sufficiently given or
made if sent by first-class or registered mail, postage prepaid, addressed
(until another address is filed in writing by the Warrant Agent with the
Company) as follows:

                         ChaseMellon Shareholder Services, L.L.C.
                         85 Challenger Road
                         Overpeck Centre
                         Ridgefield Park, New Jersey    07660
                         Attention: Corporate Trust Department


               Any notice or demand authorized to be given or made to the
registered holder of any Warrant Certificate under this Agreement shall be
sufficiently given or made if sent by first-class or registered mail, postage
prepaid, to the last address of such holder as it shall appear on the registers
maintained by the Warrant Agent.


Section 24.    MODIFICATION OF AGREEMENT

               The Warrant Agent may, without the consent or concurrence of the
Warrantholders, by supplemental agreement or otherwise, concur with the Company
in making any changes or corrections in this Agreement that the Warrant Agent
shall have been advised by counsel (who may be counsel for the Company) are
necessary or desirable to cure any ambiguity or to correct any defective or
inconsistent provision or clerical omission or mistake or manifest error herein
contained, or to make any other provisions in regard to matters or questions
arising hereunder and which shall not be inconsistent with the provisions of the
Warrant Certificates and which shall not

                                       18
<PAGE>

adversely affect the interests of the Warrantholders.  As of the date hereof, 
this Agreement contains the entire and only agreement, understanding, 
representation, condition, warranty or covenant between the parties hereto 
with respect to the matters herein, supersedes any and all other agreements 
between the parties hereto relating to such matters, and may be modified or 
amended only by a written agreement signed by both parties hereto pursuant to 
the authority granted by the first sentence of this Section.


Section 25.    SUCCESSORS

               All the covenants and provisions of this Agreement by or for the
benefit of the Company or the Warrant Agent shall bind and inure to the benefit
of their respective successors and assigns hereunder.


Section 26.    OREGON CONTRACT

               This Agreement and each Warrant Certificate issued hereunder
shall be deemed to be a contract made under the laws of the state of Oregon and
for all purposes shall be construed in accordance with the laws of said State.


Section 27.    TERMINATION

               This Agreement shall terminate as of the close of business on the
Expiration Date, or such earlier date upon which all Warrants shall have been
exercised or redeemed, except that the Warrant Agent shall account to the
Company as to all Warrants outstanding and all cash held by it as of the close
of business on the Expiration Date.


Section 28.    BENEFITS OF THIS AGREEMENT

               Nothing in this Agreement or in the Warrant Certificates shall be
construed to give to any person or corporation other than the Company, the
Warrant Agent, and their respective successors and assigns hereunder and the
registered holders of the Warrant Certificates any legal or equitable right,
remedy or claim under this Agreement; but this Agreement shall be for the sole
and exclusive benefit of the Company, the Warrant Agent, their respective
successors and assigns hereunder and the registered holders of the Warrant
Certificates.


Section 29.    DESCRIPTIVE HEADINGS

               The descriptive headings of the several sections of this
Agreement are inserted for convenience only and shall not control or affect the
meaning or construction of any of the provisions hereof.

                                       19
<PAGE>

Section 30.    COUNTERPARTS

               This Agreement may be executed in any number of counterparts,
each of which shall be an original, but such counterparts shall together
constitute one and the same instrument.


               IN WITNESS WHEREOF, the parties hereto have caused this Agreement
to be duly executed, all as of the day and year first above written.


                              ANTIVIRALS  INC.

                              By:   /s/ Denis R. Burger                   
                                  ---------------------
                              Title:     President                        
                                     ------------------
 

                              CHASEMELLON  SHAREHOLDER  SERVICES,  L.L.C.

                              By:   /s/ Dennis Treibel                    
                                  --------------------
                              Title:     Assistant Vice President         
                                     ----------------------------


                              REPRESENTATIVE:


                                     /s/ James C. L. Baxendale            
                              -----------------------------------
                              JAMES C. L. BAXENDALE

                                       20
<PAGE>

                                                                      EXHIBIT  A


                  VOID AFTER 5:00 P.M. PACIFIC TIME ON MAY 15, 2003


                          WARRANTS TO PURCHASE COMMON STOCK


W                            Warrants
 -------     ---------------

                                   ANTIVIRALS INC.


                                  CUSIP 002346 11 2





THIS CERTIFIES THAT



or registered assigns, is the registered holder of the number of Warrants
("Warrants") set forth above.  Each Warrant entitles the holder thereof to
purchase from AntiVirals, Inc., a corporation incorporated under the laws of the
State of Oregon ("Company"), subject to the terms and conditions set forth
hereinafter and in the Warrant Agreement hereinafter more fully described (the
"Warrant Agreement") referred to, one fully paid and non-assessable share of
Common Stock, $.0001 par value, of the Company ("Common Stock") upon
presentation and surrender of this Warrant Certificate with the instructions for
the registration and delivery of Common Stock filled in, at any time after
September 15, 2000 (the "Initial Exercise Date") prior to 5:00 p.m., Pacific
Time, on May 15, 2003, or, if such Warrant is redeemed as provided in the
Warrant Agreement, at any time prior to the effective time of such redemption,
at the stock transfer office in Ridgefield Park, New Jersey, of ChaseMellon
Shareholder Services, L.L.C., Warrant Agent of the Company ("Warrant Agent"), or
of its successor warrant agent or, if there be no successor warrant agent, at
the corporate offices of the Company, and upon payment of the Exercise Price (as
defined in the Warrant Agreement) and any applicable taxes paid either in cash,
or by certified or official bank check, payable in lawful money of the United
States of America to the order of the Company.  Each Warrant initially entitles
the holder to purchase one share of Common Stock for $13.50.  The number and
kind of securities or other property for which the Warrants are exercisable are
subject to further adjustment in certain events, such as mergers, splits, stock
dividends, recapitalizations and the like, to prevent dilution.  The Company may
redeem any or all outstanding and unexercised Warrants at any time if the Daily
Price has exceeded $27.00 for 20 consecutive trading days immediately preceding
the date of notice of such redemption, upon 30 days' notice, at a price equal to
$0.25 per

<PAGE>

Warrant; provided such twenty (20) consecutive day trading period has
occurred after the Initial Exercise Date and the shares of Common Stock are the
subject of an effective Registration Statement under the Securities Act of 1933,
as amended.  For the purpose of the foregoing sentence, the term "Daily Price"
shall mean, for any relevant day, the closing bid price on that day as reported
by the principal exchange or quotation system on which prices for the Common
Stock are reported.  All Warrants not theretofore exercised or redeemed will
expire on May 15, 2003.

               This Warrant Certificate is subject to all of the terms,
provisions and conditions of the Warrant Agreement, dated as of September 15,
1998 ("Warrant Agreement"), between the Company, the Warrant Agent and
James C. L. Baxendale, to all of which terms, provisions and conditions the
registered holder of this Warrant Certificate consents by acceptance hereof. 
The Warrant Agreement is incorporated herein by reference and made a part hereof
and reference is made to the Warrant Agreement for a full description of the
rights, limitations of rights, obligations, duties and immunities of the Warrant
Agent, the Company and the holders of the Warrant Certificates.  Copies of the
Warrant Agreement are available for inspection at the stock transfer office of
the Warrant Agent or may be obtained upon written request addressed to the
Company at One S.W. Columbia, Suite 1105, Portland, Oregon  97258, Attention:
Chief Executive Officer.

               The Company shall not be required upon the exercise of the
Warrants evidenced by this Warrant Certificate to issue fractions of Warrants,
Common Stock or other securities, but shall make adjustment therefor in cash on
the basis of the current market value of any fractional interest as provided in
the Warrant Agreement.

               In certain cases, the sale of securities by the Company upon
exercise of Warrants would violate the securities laws of the United States,
certain states thereof or other jurisdictions.  The Company has agreed to use
its best efforts to cause a registration statement to continue to be effective
during the term of the Warrants with respect to such sales under the Securities
Act of 1933, as amended, and to take such action under the laws of various
states as may be required to cause the sale of securities upon exercise to be
lawful.  However, the Company will not be required to honor the exercise of
Warrants if, in the opinion of the Board of Directors, upon advice of counsel,
the sale of securities upon such exercise would be unlawful.  In certain cases,
the Company may, but is not required to, purchase Warrants submitted for
exercise for a cash price equal to the difference between the market price of
the securities obtainable upon such exercise and the exercise price of such
Warrants.

               This Warrant Certificate, with or without other Certificates,
upon surrender to the Warrant Agent, any successor warrant agent or, in the
absence of any successor warrant agent, at the corporate offices of the Company,
may be exchanged for another Warrant Certificate or Certificates evidencing in
the aggregate the same number of Warrants as the Warrant Certificate or
Certificates so surrendered.  If the Warrants evidenced by this Warrant
Certificate shall be exercised in part, the holder hereof shall be entitled to
receive upon surrender hereof another Warrant Certificate or Certificates
evidencing the number of Warrants not so exercised.

               No holder of this Warrant Certificate, as such, shall be entitled
to vote,

<PAGE>

receive dividends or be deemed the holder of Common Stock or any other 
securities of the Company which may at any time be issuable on the exercise 
hereof for any purpose whatever, nor shall anything contained in the Warrant 
Agreement or herein be construed to confer upon the holder of this Warrant 
Certificate, as such, any of the rights of a stockholder of the Company or 
any right to vote for the election of directors or upon any matter submitted 
to stockholders at any meeting thereof or give or withhold consent to any 
corporate action (whether upon any matter submitted to stockholders at any 
meeting thereof, or give or withhold consent to any merger, recapitalization, 
issuance of stock, reclassification of stock, change of par value or change 
of stock to no par value, consolidation, conveyance or otherwise) or to 
receive notice of meetings or other actions affecting stockholders (except as 
provided in the Warrant Agreement) or to receive dividends or subscription 
rights or otherwise until the Warrants evidenced by this Warrant Certificate 
shall have been exercised and the Common Stock purchasable upon the exercise 
thereof shall have become deliverable as provided in the Warrant Agreement.

               If this Warrant Certificate shall be surrendered for exercise
within any period during which the transfer books for the Company's Common Stock
or other class of stock purchasable upon the exercise of the Warrants evidenced
by this Warrant Certificate are closed for any purpose, the Company shall not be
required to make delivery of certificates for shares purchasable upon such
transfer until the date of the reopening of said transfer books.

               Every holder of this Warrant Certificate by accepting the same
consents and agrees with the Company, the Warrant Agent, and with every other
holder of a Warrant Certificate that:

          (a)  this Warrant Certificate is transferable on the registry books of
the Warrant Agent only upon the terms and conditions set forth in the Warrant
Agreement, and

          (b)  the Company and the Warrant Agent may deem and treat the person
in whose name this Warrant Certificate is registered as the absolute owner
hereof (notwithstanding any notation of ownership or other writing thereon made
by anyone other than the Company or the Warrant Agent) for all purposes whatever
and neither the Company nor the Warrant Agent shall be affected by any notice to
the contrary.

               The Company shall not be required to issue or deliver any
certificate for shares of Common Stock or other securities upon the exercise of
Warrants evidenced by this Warrant Certificate until any tax which may be
payable in respect thereof by the holder of this Warrant Certificate pursuant to
the Warrant Agreement shall have been paid, such tax being payable by the holder
of this Warrant Certificate at the time of surrender.

               This Warrant Certificate shall not be valid or obligatory for any
purpose until it shall have been countersigned by the Warrant Agent.

               WITNESS the facsimile signatures of the proper officers of the
Company and its corporate seal.

<PAGE>

               Dated:                                 , 1998.
                       ------------------------------



                                   ANTIVIRALS  INC.


                                   By:                                          
                                        Chief Executive Officer


                                   Attest:                                      
                                                  Secretary



Countersigned


                                        


By:                                     
          Authorized Officer



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