CEPHALON INC
POS AM, 1999-10-15
PHARMACEUTICAL PREPARATIONS
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<PAGE>

     As filed with the Securities and Exchange Commission on October 15, 1999
                                                       Registration No.033-85776
================================================================================
                      SECURITIES AND EXCHANGE COMMISSION
                             Washington, DC  20549
                           ________________________

                        Post-Effective Amendment No. 1
                                      to
                                   Form S-3
                            REGISTRATION STATEMENT
                                     Under
                          THE SECURITIES ACT OF 1933
                           ________________________

                                CEPHALON, INC.
            (Exact name of registrant as specified in its charter)

           Delaware                  2834                     23-2484489
       (State or other         (Primary Standard            (I.R.S. Employer
       jurisdiction of            Industrial               Identification No.)
       incorporation or       Classification No.)
        organization)
                            145 Brandywine Parkway
                            West Chester, PA 19380
                                (610) 344-0200
   (Address, including zip code, and telephone number, including area code,
                 of registrant's principal executive offices)
                           ________________________

                             JOHN E. OSBORN, ESQ.
             Senior Vice President, General Counsel and Secretary
                                Cephalon, Inc.
                            145 Brandywine Parkway
                            West Chester, PA 19380
                                (610) 344-0200
(Name, address, including zip code, and telephone number, including area code,
                             of agent for service)
                          _________________________

                       Copies of all communications to:
                              DAVID R. KING, ESQ.
                          Morgan, Lewis & Bockius LLP
                              1701 Market Street
                            Philadelphia, PA  19103
                                (215) 963-5000

Approximate date of commencement of proposed sale to the public:  Completed.

If the only securities being registered on this Form are being offered pursuant
to dividend or interest reinvestment plans, please check the following box. [_]

If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. [_]

If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the Securities Act registration statement number of the earlier effective
registration statement for the same offering. [_]

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [_]

If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box.[_]
                            _______________________
<PAGE>

Pursuant to a Registration Statement on Form S-3 (File No. 033-85776) filed with
the Commission on October 28, 1994 (the "Registration Statement"), Cephalon,
Inc. (the "Company") registered an aggregate of 1,225,532 of the Company's
common stock, $0.01 par value per share (the "Common Stock") for the account of
TAP Pharmaceuticals Inc. (the "Selling Stockholder").  The Company's obligation
to the Selling Stockholder to keep the Registration Statement effective has
terminated.  Accordingly, this post-effective amendment No. 1 to the
Registration Statement is being filed for the purpose of deregistering any and
all of the shares of Common Stock of the Company registered pursuant to the
Registration Statement that have not been sold thereunder and terminating the
Registration Statement.
<PAGE>

                                  SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the registrant has
duly caused this Post-Effective Amendment No. 1 to the Registration Statement to
be signed on its behalf by the undersigned thereunto duly authorized, in West
Chester, Pennsylvania, on this 15th day of October, 1999.

                                      CEPHALON, INC.

                                      By: /s/ Frank Baldino, Jr., Ph.D.
                                         -----------------------------------
                                          Frank Baldino, Jr., Ph.D.
                                          President, Chief Executive Officer and
                                          Director

Pursuant to the requirements of the Securities Act of 1933, this Post-Effective
Amendment No. 1 to the Registration Statement has been signed below by the
following persons in the capacities and on the dates indicated.

<TABLE>
<CAPTION>
                    Name                                 Title                         Date
                    ----                                 -----                         ----
<S>                                            <C>                                 <C>
By: /s/ Frank Baldino, Jr., Ph.D.              President, Chief Executive          October 15, 1999
    -----------------------------
     Frank Baldino, Jr., Ph.D.                 Officer and Director
                                               (Principal executive officer)

By: /s/ William P. Egan                        Director                            October 15, 1999
   ------------------------------
     William P. Egan


By: /s/ Robert J. Feeney, Ph.D.                Director                            October 15, 1999
    -----------------------------
     Robert J. Feeney, Ph.D.


By: /s/ Martyn D. Greenacre                    Director                            October 15, 1999
    -----------------------------
     Martyn D. Greenacre


By: /s/ Kevin E. Moley                         Director                            October 15, 1999
   ------------------------------
     Kevin E. Moley


By: /s/ Horst Witzel, Dr.-Ing.                 Director                            October 15, 1999
    -----------------------------
     Horst Witzel, Dr.-Ing.


By: /s/ David R. King                          Director                            October 15, 1999
    -----------------------------
     David R. King


By: /s/ J. Kevin Buchi                         Senior Vice President, Finance      October 15, 1999
    -----------------------------
     J. Kevin Buchi                            and Chief Financial Officer
                                               (Principal financial and
                                               accounting officer)
</TABLE>


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