MEDIMMUNE INC /DE
DEF 14A, 1999-04-16
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                            SCHEDULE 14A INFORMATION

PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES EXCHANGE ACT OF 1934
                        (AMENDMENT NO. . . . . . . . . )

Filed by the Registrant [X]
Filed by a Party other than the Registrant [   ]

Check the appropriate box:

[ ]  Preliminary Proxy Statement
[ ]  Confidential,  for  Use  of the  Commission  Only  (as  permitted  by  Rule
     14a-6(e)(2))
[X]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to Section 240.14a-11(c) or Section 240.14a-12


                                MEDIMMUNE, INC.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)


- --------------------------------------------------------------------------------
     (Name of Person(s) Filing Proxy Statement if other than the Registrant)


Payment of Filing Fee (Check the appropriate box):

[X]  No fee required.
[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
     1)   Title of each class of securities to which transaction applies:

          ----------------------------------------------------------------------
     2)   Aggregate number of securities to which transaction applies:

          ----------------------------------------------------------------------
     3)   Per unit  price  or other  underlying  value of  transaction  computed
          pursuant to Exchange  Act Rule 0-11 (Set forth the amount on which the
          filing fee is calculated and state how it was determined):

          ----------------------------------------------------------------------
     4)   Proposed maximum aggregate value of transaction:

          ----------------------------------------------------------------------
     5)   Total fee paid:

          ----------------------------------------------------------------------
[ ]  Fee paid previously with preliminary materials.

[ ]  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2)  and identify the filing for which the  offsetting  fee was paid
     previously.  Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.

     1)   Amount Previously Paid:
                                 -----------------------------------------------

     2)   Form, Schedule or Registration Statement No.:
                                                       -------------------------

     3)   Filing Party:
                       ---------------------------------------------------------

     4)   Date Filed:
                     -----------------------------------------------------------


<PAGE>








                         [MEDIMMUNE, INC. LOGO OMITTED]



                                                                               1

                                MEDIMMUNE, INC.



                                                                               9

                                   NOTICE OF

                                 ANNUAL MEETING
                                                                               9
                                   AND PROXY

                                   STATEMENT

                                                                               9











<PAGE>



                         [MEDIMMUNE, INC. LOGO OMITTED]


                                MEDIMMUNE, INC.




                                                                 April 16, 1999



Dear MedImmune Stockholder:

     You are cordially  invited to attend the Annual Meeting of  Stockholders to
be held at the Gaithersburg  Marriott,  Washingtonian Center, 9751 Washingtonian
Boulevard,  Gaithersburg,   Maryland  20878  on  May  20,  1999  at  10:00  a.m.
Information  about the meeting,  the nominees for directors and the proposals to
be  considered  is  presented  in the  Notice  of Annual  Meeting  and the Proxy
Statement on the following pages.

     In  addition  to the formal  items of  business  to be  brought  before the
meeting,  I will report on our Company's  operations  during 1998.  This will be
followed by a question and answer period.

     Your participation in MedImmune's  affairs is important,  regardless of the
number of shares you hold.  To ensure  your  representation,  even if you cannot
attend the meeting, please sign, date and return the enclosed proxy promptly.

     We look forward to seeing you on May 20th.



                                     Sincerely,

                                     /s/ WAYNE T. HOCKMEYER, PH.D.

                                     WAYNE T. HOCKMEYER, PH.D.
                                     Chairman and Chief Executive Officer



     -----------------------------------------------------------------------
          35 West Watkins Mill Road      Gaithersburg, Maryland 20878
                         301-417-0770 Fax: 301-527-4200


<PAGE>



                         [MEDIMMUNE, INC. LOGO OMITTED]


                                MEDIMMUNE, INC.



- --------------------------------------------------------------------------------
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                                  MAY 20, 1999
- --------------------------------------------------------------------------------

     The Annual Meeting of Stockholders  of MedImmune,  Inc. will be held at the
Gaithersburg  Marriott,  Washingtonian  Center,  9751  Washingtonian  Boulevard,
Gaithersburg,  Maryland  on May  20,  1999 at  10:00  a.m.,  for  the  following
purposes:

     1.   To elect nine directors;

     2.   To approve the MedImmune, Inc. 1999 Stock Option Plan;

     3.   To approve and ratify the appointment of PricewaterhouseCoopers L.L.P.
          as independent auditors; and

     4.   To  transact  such other  business  as  properly  may come  before the
          meeting and any adjournment thereof.

     Stockholders  of  record  at the close of  business  on March 31,  1999 are
entitled to receive notice of, and to vote at, the Annual Meeting.


                                     By Order of the Board of Directors,

                                     /s/ Carol A. Iorio

                                     Carol A. Iorio
                                     Corporate Secretary



35 West Watkins Mill Road
Gaithersburg, Maryland 20878
April 16, 1999


<PAGE>



- --------------------------------------------------------------------------------
                                PROXY STATEMENT
- --------------------------------------------------------------------------------


                              GENERAL INFORMATION

     This Proxy  Statement is furnished in connection  with the  solicitation by
the Board of Directors of  MedImmune,  Inc.  ("MedImmune"  or the  "Company") of
proxies to be voted at the Annual Meeting of  Stockholders on May 20, 1999. This
Proxy Statement,  the accompanying  proxy card and Annual Report to Stockholders
are being mailed to  stockholders  on or about April 16,  1999.  Business at the
Annual Meeting is conducted in accordance with the procedures  determined by the
presiding  officer and is generally  limited to matters  properly brought before
the  meeting  by  or at  the  suggestion  of  the  Board  of  Directors  or by a
stockholder  pursuant to provisions  requiring  advance notice and disclosure of
relevant information.

     The number of voting securities of MedImmune outstanding on March 31, 1999,
the record date for the meeting, was 55,622,518 shares of common stock, $.01 par
value per share, each share being entitled to one vote. Stockholders do not have
cumulative voting rights.


VOTING OF PROXIES

     Since many MedImmune stockholders are unable to attend the Company's Annual
Meeting,  the Board of Directors  solicits  proxies to give each  stockholder an
opportunity to vote on all matters  scheduled to come before the meeting and set
forth in this Proxy  Statement.  Stockholders  are urged to read  carefully  the
material in this Proxy Statement, specify their choice on each matter by marking
the appropriate  boxes on the enclosed proxy card, and sign, date and return the
card in the enclosed stamped envelope.

     If no choice is specified and the card is properly signed and returned, the
shares will be voted by the Proxy  Committee as  recommended  by the Company.  A
stockholder who signs a proxy may revoke or revise that proxy at any time before
the meeting. A previously  returned proxy may be canceled by voting by ballot at
the meeting. Stockholder proxies are received by American Stock Transfer & Trust
Company,  the Company's  independent  proxy  processing  agent,  and the vote is
certified by Inspectors of Election.

     MedImmune's  Proxy Committee  consists of Dr. Wayne T. Hockmeyer,  Chairman
and Chief  Executive  Officer,  and Mr. David M. Mott,  Vice  Chairman and Chief
Financial Officer.  Proxy cards,  unless otherwise indicated by the stockholder,
also confer upon the Proxy Committee  discretionary authority to vote all shares
of  stock  represented  by the  proxies  on any  matter  which  properly  may be
presented  for action at the meeting even if not covered  herein.  If any of the
nominees  for director  named in Proposal 1 -- Election of  Directors  should be
unavailable  for  election,  the proxies  will be voted for the election of such
other person as may be recommended by the Company in place of such nominee.

     Stockholders  of record at the close of  business  on March 31,  1999,  are
entitled  to receive  notice of the  meeting and to vote the shares held on that
date. The holders of a majority of the issued and outstanding shares of stock of
the Company  entitled to vote at the meeting must be represented in person or by
proxy at the Annual Meeting in order for the meeting to be held.  Other than the
election of directors, which requires


                                        1

<PAGE>



a  plurality  of  the votes of the stockholders represented at the meeting, each
matter  to be submitted to the stockholders requires the affirmative vote of the
holders  of a majority of the shares represented at the meeting, in person or by
proxy,  and entitled to vote. Abstentions have the same effect as a vote against
any  such  matter.  Broker non-votes are deemed not entitled to vote and are not
counted as votes for or against any such matter.


ATTENDANCE AT ANNUAL MEETING

     To ensure the  availability  of adequate  space for MedImmune  stockholders
wishing to attend the meeting, priority seating will be given to stockholders of
record,  beneficial  owners  of the  Company's  stock  having  evidence  of such
ownership,   or  their  authorized   representatives,   and  invited  guests  of
management.  In  addition,  a  stockholder  may bring one  guest.  In order that
seating may be equitably allocated, a stockholder wishing to bring more than one
guest must write to the  Corporate  Secretary  in  advance  of the  meeting  and
receive  written  concurrence.  Those  unable to  attend  may  request  from the
Corporate Secretary a copy of the report of the proceedings of the meeting.


                       PROPOSAL 1 -- ELECTION OF DIRECTORS

     A Board of nine  directors  is to be elected at the  Annual  Meeting,  each
director so elected to hold office for a term of one year and until the election
and  qualification  of a  successor.  All  directors  hold office until the next
annual meeting of stockholders  and until their  successors are duly elected and
qualified.  The Company's  By-Laws authorize the Board of Directors from time to
time to determine  the number of its members.  Vacancies in unexpired  terms and
any  additional  positions  created by board  action are filled by action of the
existing Board of Directors.


THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE FOLLOWING NOMINEES:

     WAYNE T. HOCKMEYER, PH.D.

     Dr.  Hockmeyer  (age 54) founded the Company in April 1988 as President and
     Chief Executive  Officer and was elected to serve on the Board of Directors
     in May 1988. He became Chairman of the Board of Directors in May 1993. From
     1986 to  1988,  Dr.  Hockmeyer  served  as  Vice  President,  Research  and
     Development,  of Praxis  Biologics,  Inc. From 1980 to 1986, Dr.  Hockmeyer
     served as Chairman, Department of Immunology, Walter Reed Army Institute of
     Research.  Dr. Hockmeyer is a member of the Maryland  Economic  Development
     Commission,  a member of the  Board of  Directors  of  Digene  Corporation,
     serves on the Advisory  Board of the  University of Maryland  Biotechnology
     Institute,  is a member  of Board of  Advisors  of the  Institute  of Human
     Virology,  is a Member of the  Board of  Directors  of the High  Technology
     Council of Maryland,  is Chairman of the Maryland Bioscience Alliance and a
     member of the University of Maryland  University  College  Graduate  School
     Advisory Board,  Executive  Programs.  Dr. Hockmeyer received a Bachelor of
     Science  degree from Purdue  University and a doctorate from the University
     of Florida.

     MELVIN D. BOOTH

     Mr.  Booth (age 54) joined the  Company in October  1998 as  President  and
     Chief Operating  Officer and was elected to serve on the Board of Directors
     in November 1998.  Prior to joining the Company,  he was  President,  Chief
     Operating  Officer and a member of the Board of  Directors  of Human Genome
     Sci-


                                        2

<PAGE>



     ences,  Inc.  from July 1995 until October  1998.  Prior to this time,  Mr.
     Booth was employed at Syntex Corporation from 1975 to 1995, where he held a
     variety of positions, including President of Syntex Laboratories, Inc. from
     1993 to 1995 and Vice  President of Syntex  Corporation  from 1992 to 1995.
     From 1992 to 1993,  he served as the  President  of Syntex  Pharmaceuticals
     Pacific.  From 1991 to 1992, he served as an area Vice President of Syntex,
     Inc. From 1986 to 1991, he served as the President of Syntex, Inc., Canada.
     Mr.  Booth  is  a  past  Chairman  of  the   Pharmaceutical   Manufacturers
     Association  of Canada and  currently is a member of the Board of Directors
     of Neoprobe Corporation.  Mr. Booth graduated from Northwest Missouri State
     University and holds a Certified Public Accountant Certificate.

     DAVID M. MOTT

     Mr. Mott (age 33) joined the Company in April 1992 as Vice President,  with
     responsibility  for business  development,  strategic planning and investor
     relations.  In 1994,  Mr. Mott assumed  additional  responsibility  for the
     medical and regulatory  groups,  and in March 1995 was appointed  Executive
     Vice President and Chief Financial Officer.  In November 1995, Mr. Mott was
     appointed to the position of President and Chief Operating  Officer and was
     elected to the Board of Directors.  In October 1998, Mr. Mott was appointed
     Vice Chairman and Chief Financial Officer. Prior to joining the Company, he
     was a Vice President in the Health Care  Investment  Banking Group at Smith
     Barney,  Harris Upham & Co.,  Inc. At Smith  Barney,  where he was employed
     from July 1986 to April 1992,  Mr. Mott's  activities  included  public and
     private equity and debt financings as well as merger and  acquisition  work
     for  biotechnology,  healthcare  services,  and medical  product and device
     companies.  Mr.  Mott is a member of the Board of  Directors  of  Conceptis
     Technologies.  He  holds  a  Bachelor  of  Arts  degree  in  economics  and
     government from Dartmouth College.

     FRANKLIN H. TOP, JR., M.D.

     Dr.  Top (age  63)  joined  the  Company  in June  1988 as  Executive  Vice
     President. He was elected to the Board of Directors in July 1988 and became
     the Company's  Medical  Director in 1990. From 1987 to 1988, Dr. Top served
     as Senior Vice  President  for Clinical and  Regulatory  Affairs at Praxis.
     Prior to 1987,  Dr.  Top  served  for 22  years  in the U.S.  Army  Medical
     Research and Development Command,  where he was appointed Director,  Walter
     Reed Army  Institute  of  Research in 1983.  Dr. Top holds a  doctorate  of
     medicine cum laude and a Bachelor of Science  degree in  biochemistry  from
     Yale University.

     M. JAMES BARRETT, PH.D.

     Dr.  Barrett (age 56) has been a director of the Company  since 1988 and is
     the  Chairman,  Chief  Executive  Officer  and a director  of  Sensors  for
     Medicine and Science,  Inc. From July 1987 to September  1996, he was Chief
     Executive Officer and a director of Genetic Therapy, Inc. From 1982 to July
     1987, Dr. Barrett  served as President of Life  Technologies,  Inc. and its
     predecessor,  Bethesda  Research  Laboratories,  Inc. Prior to 1982, he was
     employed at SmithKline  Beecham  Corporation for 13 years,  where he held a
     variety  of  positions,  including  President  of its In  Vitro  Diagnostic
     Division and President of SmithKline  Clinical  Laboratories.  Dr.  Barrett
     holds a doctorate in  biochemistry  from the  University of Tennessee and a
     master's  degree in business  administration  from the  University of Santa
     Clara.

     JAMES H. CAVANAUGH, PH.D.

     Dr.  Cavanaugh (age 62) has been a director of the Company since  September
     1990 and has been President of HealthCare Ventures L.L.C. since 1989. Prior
     thereto,  Dr.  Cavanaugh  served as  President  of  SmithKline  and  French
     Laboratories U.S., Inc., from March 1985 to February 1989 and as President


                                        3

<PAGE>



     of SmithKline Clinical  Laboratories from 1981 to 1985. Prior thereto,  Dr.
     Cavanaugh was the President of Allergan International, a specialty eye care
     company. Dr. Cavanaugh also serves as a member of the Board of Directors of
     Human Genome Sciences,  Inc.,  3-Dimensional  Pharmaceuticals,  Inc., Shire
     Pharmaceuticals Group PLC, LeukoSite,  Inc., and Diversa Corp. Prior to his
     industry  experience,  Dr.  Cavanaugh was Deputy Assistant to the President
     for Domestic Affairs and Deputy Chief of the White House Staff.  Before his
     White House tour,  he served as Deputy  Assistant  Secretary for Health and
     Scientific Affairs in the U.S. Department of Health,  Education and Welfare
     and as Special  Assistant to the Surgeon  General of the U.S. Public Health
     Service.  In  addition  to serving on the  boards of  directors  of several
     health care and biotechnology  companies, Dr. Cavanaugh currently serves on
     the Board of Trustees of the  National  Committee  for Quality  Health Care
     (Chairman,  1988) and as  Trustee  Emeritus  of the  California  College of
     Medicine.  He has served on the Board of  Directors  of the  Pharmaceutical
     Manufacturers   Association,   Unihealth   America,   and  the  Proprietary
     Association.  He was a Founding  Director  of the Marine  National  Bank in
     Santa Ana,  California.  Dr.  Cavanaugh  holds a  doctorate  and a master's
     degree from the  University  of Iowa and a Bachelor of Science  degree from
     Fairleigh Dickinson University.

     BARBARA HACKMAN FRANKLIN

     Ms.  Franklin  (age 59) has been a director of the Company  since  November
     1995  and,  since  January  1995,  has  served as the  President  and Chief
     Executive Officer of Barbara Franklin Enterprises,  a private international
     consulting and investment firm in Washington, D.C. Between January 1993 and
     January  1995,  Ms.  Franklin  was a lecturer  and served as a director  of
     various corporations and organizations.  Previously, Ms. Franklin served as
     the 29th U.S.  Secretary of  Commerce.  She has also served as an Alternate
     Representative  to the United Nations General Assembly and was appointed to
     four  terms on the  President's  Advisory  Council  for  Trade  Policy  and
     Negotiations.  Ms. Franklin founded Franklin Associates, an internationally
     recognized  consulting  firm, and served as its President from 1984 through
     1992,  was  Senior  Fellow  of the  Wharton  School  of the  University  of
     Pennsylvania  (1979-1988),  one of the original  Commissioners  of the U.S.
     Consumer Product Safety Commission (1973-1979) and a staff assistant to the
     President,  creating the first White House effort to recruit women for high
     level  government jobs  (1971-1973).  Ms. Franklin  currently serves on the
     board of directors of Aetna Inc., The Dow Chemical  Company,  AMP Inc., and
     Milacron, Inc. She has been a director of the Nasdaq Stock Market, Inc. and
     the  American   Institute  of  CPA's.  Ms.  Franklin   graduated  from  The
     Pennsylvania  State  University and received a master's  degree in business
     administration from Harvard University.

     LAWRENCE C. HOFF

     Mr. Hoff (age 70) has been a director of the Company  since April 1991.  In
     1990,  Mr. Hoff retired as  President  and Chief  Operating  Officer of the
     Upjohn Company.  Mr. Hoff joined Upjohn in 1950 as a  pharmaceutical  sales
     representative. He was appointed Vice President for Domestic Pharmaceutical
     marketing in 1969. In 1973,  Mr. Hoff was elected to the Board of Directors
     of Upjohn and the following year became Vice President and General  Manager
     of Domestic  Pharmaceutical  Operations.  He was promoted to Executive Vice
     President in 1977,  was named  President in 1984,  and  President and Chief
     Operating  Officer in 1987.  Mr. Hoff was elected to the Board of Directors
     of the  Pharmaceutical  Manufacturers  Association  ("PMA") in 1984. He was
     elected  Chairman-elect  of the PMA in 1986 and Chairman in 1987.  Mr. Hoff
     currently serves on the board of directors of Curative Health Systems, Inc.
     He graduated  from Stanford  University and has received  honorary  degrees
     from the  Massachusetts  College of Pharmacy and Allied Health Sciences and
     from Kalamazoo College.


                                        4

<PAGE>



     GORDON S. MACKLIN

     Mr.  Macklin  (age 70) has been a director of the Company  since July 1994.
     Mr. Macklin served as Chairman of the White River  Corporation from 1994 to
     June 1998,  and as President  and Chief  Executive  Officer from January to
     June 1998.  From 1987 through  1992, he was Chairman of Hambrecht and Quist
     Group,  an investment  banking and venture  capital firm.  Previously,  Mr.
     Macklin was President of the National  Association  of Securities  Dealers,
     Inc.  from 1970  through  1987.  He also  served as  Chairman  of  National
     Clearing  Corporation  (1970 to 1975)  and as a partner  and  member of the
     Executive  Committee of McDonald & Company  Securities,  Inc.  where he was
     employed  from  1950  through  1970.  Mr.  Macklin  serves  on the Board of
     Directors of Fund American Enterprises Holdings,  Inc., MCI WorldCom, Inc.,
     Martek  Biosciences  Corporation,  Spacehab,  Inc.,  Real 3D, and director,
     trustee  or  managing  general  partner,  as the case may be,  of 49 of the
     investment companies in the Franklin Templeton Group of Funds.


THE BOARD OF DIRECTORS AND ITS COMMITTEES

Board Meetings

     During 1998,  the Board of Directors  met seven  times,  and all  directors
attended more than 75% of the meetings of the Board.

Committees of the Board

     Committees of the Board of Directors  consist of the Audit  Committee,  the
Compensation  and  Stock  Committee  and the  Executive  Committee.  Information
concerning the committees is set forth below.  All directors  attended more than
75% of the meetings of the Board  Committees  on which they  served,  except Mr.
Hoff who was unable to attend one meeting of the Audit Committee.

     The Audit Committee oversees the performance, and reviews the scope, of the
audit performed by the Company's  independent  accountants.  The Audit Committee
also reviews audit plans and procedures,  changes in accounting policies and the
use of the independent  accountants for non-audit services.  The Audit Committee
consists of Mr. Hoff  (Chairman),  Dr.  Barrett,  Ms.  Franklin and Mr. Macklin.
During 1998, the Audit Committee met three times.

     The  Compensation  and Stock  Committee  determines  the  compensation  and
benefits  of all  officers  of the  Company  and  establishes  general  policies
relating  to  compensation  and  benefits  of  employees  of  the  Company.  The
Compensation  and Stock  Committee is also  responsible  for  administering  the
Company's 1991 Stock Option Plan (the "1991 Plan") in accordance  with the terms
and conditions set forth therein.  The Compensation and Stock Committee consists
of Dr. Cavanaugh  (Chairman),  Dr. Barrett,  Ms.  Franklin,  Mr. Macklin and Mr.
Hoff, with Dr. Hockmeyer serving as a non-voting ex officio member. During 1998,
the Compensation and Stock Committee met six times.

     The Executive  Committee is responsible for all matters which arise between
regular meetings of the Board of Directors to the extent permitted by applicable
law. The Executive Committee consists of Dr. Hockmeyer (Chairman),  Dr. Barrett,
Dr. Cavanaugh and Mr. Macklin. During 1998, the Executive Committee met once.


                                        5

<PAGE>



        COMPENSATION AND STOCK COMMITTEE REPORT ON EXECUTIVE COMPENSATION

     Compensation of the Company's  executives is subject to review and approval
by the Compensation and Stock Committee (the "Committee") of the Company's Board
of  Directors.  The  Committee  consists  of five  outside  directors  (James H.
Cavanaugh,  Ph.D. (Chairman), M. James Barrett, Ph.D., Barbara Hackman Franklin,
Lawrence C. Hoff and Gordon S.  Macklin) and the  Chairman  and Chief  Executive
Officer of the Company (Wayne T. Hockmeyer,  Ph.D.),  who serves as a non-voting
ex officio member.

     In determining the 1998 compensation to be paid to the Company's  executive
officers,  the Committee employed  compensation  policies designed to align such
compensation  with the interests of the Company's  stockholders and to relate it
to overall  corporate  performance.  These  policies are intended to attract and
retain  executives whose abilities are critical to the long-term  success of the
Company, to support a performance-oriented  environment that rewards achievement
of internal  corporate  goals and to reward  executives  for the  enhancement of
stockholder value.

     The components of the compensation of each executive officer, including the
Chief  Executive  Officer,  are base salary,  cash bonus awards and stock option
grants, as described below:

          Base salaries of the executive  officers are targeted to be within the
     competitive  range  among  biotechnology  companies  similar in size to the
     Company.  The Committee  utilizes the annual survey report of approximately
     400 biotechnology  companies prepared by a leading compensation  consulting
     firm for this  purpose.  The base  salaries of the  executive  officers are
     subject to certain minimums set forth in individual employment agreements.

          Cash  bonuses  are  designed  to provide  annual  incentives  based on
     individual  performance in achieving the Company's  annual  business goals.
     For 1998,  these goals included  expanding the market presence and sales of
     the Company's  FDA-approved  products,  further  advancing the development,
     manufacture  and  marketing  of new  therapeutic  and vaccine  products and
     continuing  to recruit and train the  Company's  scientific,  marketing and
     manufacturing  teams.  The Committee  makes the  determination  as to bonus
     awards at the end of each year based on the  subjective  evaluation  of the
     contributions  of each  executive  officer  towards the  achievement of the
     Company's annual business goals.

          Stock  option  grants  are  intended  to provide  the most  meaningful
     component of executive compensation.  Stock options provide compensation in
     a manner  that is  intrinsically  related to  long-term  stockholder  value
     because  options have value only to the extent of share  appreciation  from
     date of grant.  Stock  options  granted  by the  Company  generally  become
     exercisable in 25% annual increments  beginning on the first anniversary of
     the date of grant  and  remain  exercisable  for 10 years  from the date of
     grant unless the optionee's employment with the Company is terminated.

     The Committee  believes that periodic stock option grants are  appropriate,
particularly in view of the absence of a  Company-sponsored  long-term incentive
or pension plan.  Periodic  awards of stock options are granted to executives at
the discretion of the Committee,  based on an individual's  contribution  toward
achieving the Company's  strategic and product  development  goals.  These goals
include:   developing   product   candidates  with  significant   potential  for
commercialization; driving product candidates through the research, development,
regulatory approval, manufacturing and commercialization


                                        6

<PAGE>



process;  and  establishing  strategic  alliances  with  corporate  partners and
research  institutions  to leverage the  Company's  resources  and to expand its
research and  development  pipeline.  The Committee  also takes into account the
number of stock options previously granted.

     The  Compensation  and Stock Committee  based the 1998  compensation of the
Chief  Executive  Officer  and the  Company's  other  executive  officers on the
policies  described above. The base salaries of the Chief Executive  Officer and
the Company's other executive officers generally  increased in 1998 commensurate
with their increased  responsibilities  and the growth in scope of the Company's
operations. The 1998 cash bonuses paid to the executive officers,  including the
Chief  Executive  Officer,  were  based on the  achievement  during  the year of
individual  productivity  and  performance  goals  consistent with the Company's
annual business goals. In January 1998, new stock option grants were made to the
executive  officers,  including the Chief Executive Officer.  These stock option
grants  were made by the  Committee  as part of the  program of making  periodic
stock option  grants to  executive  officers,  with the number of stock  options
granted to each officer  determined on the basis of such officer's  contribution
toward achieving the Company's 1997 strategic and product  development goals, as
described above. See "Executive Compensation."

     A  federal  tax  law   disallows   corporate   deductibility   for  certain
compensation paid in excess of $1 million to the chief executive officer and the
four other most highly paid  executive  officers  of  publicly  held  companies.
"Performance-based  compensation,"  as defined in the tax law, is not subject to
the deductibility  limitation  provided certain  stockholder  approval and other
requirements  are met. The Company  believes that the stock  options  granted in
1998 and prior  years  satisfied  the  requirements  of federal tax law and thus
compensation   recognized  in  connection  with  such  awards  should  be  fully
deductible.   It  is  the  Company's  intention  to  make  efforts  to  maximize
deductibility of compensation  paid to its officers under such law. During 1998,
the Company did not exceed the $1 million  deductibility cap with respect to any
officer covered by such law.



                                        James H. Cavanaugh, Ph.D., Chairman
                                        M. James Barrett, Ph.D.
                                        Barbara Hackman Franklin
                                        Lawrence C. Hoff
                                        Gordon S. Macklin
                                        Wayne T. Hockmeyer, Ph.D., ex officio


                                        7

<PAGE>



COMPENSATION AND STOCK COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     Dr. Hockmeyer,  the Company's  Chairman and Chief Executive  Officer,  is a
non-voting ex officio member of the Compensation and Stock Committee.


EXECUTIVE COMPENSATION

Summary Compensation Table

     The following table summarizes the compensation  paid by the Company to its
Chief Executive Officer and the Company's six most highly compensated  executive
officers  other  than the Chief  Executive  Officer  (collectively,  the  "Named
Executive Officers") for the last three years.

<TABLE>
<CAPTION>
                                                                                                LONG-TERM
                                                          ANNUAL COMPENSATION                  COMPENSATION
                                            -----------------------------------------------   -------------
                                                                            OTHER ANNUAL          OPTION
   NAME AND PRINCIPAL POSITION      YEAR     SALARY ($)     BONUS ($)     COMPENSATION ($)      AWARDS (#)
- --------------------------------   ------   ------------   -----------   ------------------   -------------
<S>                                <C>      <C>            <C>           <C>                  <C>
Wayne T. Hockmeyer .............   1998       435,000        350,000               --            240,000
 Chairman and CEO                  1997       353,333        225,000               --            240,000
                                   1996       313,939        120,000               --            150,000

Melvin D. Booth (1) ............   1998       103,034        250,000               --            500,000
 President and COO

David M. Mott ..................   1998       358,668        250,000               --            200,000
 Vice Chairman and CFO             1997       271,504        200,000               --            200,000
                                   1996       240,933        100,000               --             70,000

Franklin H. Top, Jr. ...........   1998       239,680        150,000               --             80,000
 Executive Vice President          1997       210,806        100,000               --             60,000
 and Medical Director              1996       196,289         50,000               --             60,000

David P. Wright ................   1998       242,680        200,000               --             80,000
 Executive Vice President,         1997       229,833        100,000               --             60,000
 Sales and Marketing               1996       222,767         40,000               --             60,000

James F. Young .................   1998       239,513        150,000               --            150,000
 Executive Vice President,         1997       208,907        100,000               --             60,000
 Research & Development            1996       189,565         40,000               --             60,000

Bogdan Dziurzynski (2) .........   1998       206,500        150,000           16,500             80,000
 Senior Vice President,            1997       183,499        100,000           16,501            160,000
 Regulatory Affairs                1996       178,975         40,000           10,644             60,000
 and Quality Assurance
</TABLE>

- ----------
(1)  Hired in October 1998.
(2)  Mr.  Dziurzynski's  other  compensation  consisted  of a forgiven  loan and
     tuition  expense  reimbursement  in 1998 and 1997,  and a forgiven loan and
     relocation expense reimbursement in 1996.


                                        8

<PAGE>



Option Grants in Fiscal 1998

     The following table sets forth  information  relating to the grant of stock
options by the Company during 1998 to the Named Executive Officers.

<TABLE>
<CAPTION>
                                                                                         POTENTIAL REALIZABLE VALUE
                                                                                           AT ASSUMED ANNUAL RATES
                                                                                         OF STOCK PRICE APPRECIATION
                                                   INDIVIDUAL GRANTS                         FOR OPTION TERM (1)
                                 -----------------------------------------------------   ---------------------------
                                                 % OF TOTAL
                                   NUMBER OF       OPTIONS
                                  SECURITIES     GRANTED TO     EXERCISE
                                  UNDERLYING      EMPLOYEES     OR BASE
                                    OPTIONS       IN FISCAL      PRICE      EXPIRATION
             NAME                   (#)(2)          1998         ($/SH)        DATE          5%($)         10%($)
- ------------------------------   ------------   ------------   ---------   -----------   ------------   ------------
<S>                              <C>            <C>            <C>         <C>           <C>            <C>
Wayne T. Hockmeyer ...........      240,000          9.96%        22.19      1/29/08       3,354,674      8,466,559
Melvin D. Booth ..............      500,000         20.74%        33.00      10/5/08      10,395,000     26,235,000
David M. Mott ................      200,000          8.30%        22.19      1/29/08       2,795,562      7,055,466
Franklin H. Top, Jr. .........       80,000          3.32%        22.19      1/29/08       1,118,225      2,822,186
David P. Wright ..............       80,000          3.32%        22.19      1/29/08       1,118,225      2,822,186
James F. Young ...............      150,000          6.22%        22.19      1/29/08       2,096,672      5,291,600
Bogdan Dziurzynski ...........       80,000          3.32%        22.19      1/29/08       1,118,225      2,822,186
</TABLE>

- ----------
(1)  The indicated  dollar amounts are the result of  calculations  based on the
     exercise price of each option and assume five and ten percent  appreciation
     rates set by the Securities and Exchange Commission and, therefore, are not
     intended to forecast possible future appreciation, if any, of the Company's
     stock price.

(2)  Granted options become  exercisable in 25% annual  increments  beginning on
     the first anniversary of the date of grant.


Aggregated Option Exercises in 1998 and Fiscal Year-End Values

     The  following  table sets forth  information  relating to the  exercise of
stock options by the Named Executive  Officers during 1998, the number of shares
covered by stock  options held by them at December 31, 1998,  and also shows the
value of their "in-the-money"  options (market price of the Company's stock less
the exercise price) at that date.

<TABLE>
<CAPTION>
                                                                        NUMBER OF SECURITIES                                     
                                                                       UNDERLYING UNEXERCISED           VALUE OF UNEXERCISED     
                                                                          OPTIONS HELD AT             IN-THE-MONEY OPTIONS AT    
                             SHARES                                    DECEMBER 31, 1998 (#)           DECEMBER 31, 1998 ($)     
                            ACQUIRED               VALUE         ---------------------------------- ---------------------------- 
             NAME          ON EXERCISE (#)        REALIZED ($)       EXERCISABLE     UNEXERCISABLE   EXERCISABLE   UNEXERCISABLE 
- ------------------------ -----------------    ----------------   ------------------ --------------- ------------- -------------- 
<S>                       <C>               <C>                  <C>                <C>             <C>           <C>            
Wayne T. Hockmeyer ...... 210,000                 6,122,312            315,000         515,000       12,537,735     18,264,155   
Melvin D. Booth .........       -                         -                  -         500,000                -      8,359,500   
David M. Mott ........... 500,000                15,054,361            267,578         435,000       11,482,437     15,492,265   
Franklin H. Top, Jr. ....       -                         -            404,372         167,500       17,929,468      5,929,848   
David P. Wright ......... 294,322                 8,697,660             64,154         155,000        2,711,835      5,352,110   
James F. Young ..........  40,720 (1)             1,059,306 (1)        246,792 (2)     237,500       12,053,158      7,857,088   
Bogdan Dziurzynski ......  70,000                 1,690,422             51,250         211,250        2,168,099      7,386,329   
                                                                 
</TABLE>

- ----------
(1)  Excludes transfer of beneficial interest in 59,400 acquired shares pursuant
     to a qualified domestic relations order.

(2)  Excludes 36,320 shares that are subject to a qualified  domestic  relations
     order.


                                        9

<PAGE>



Employment Agreements

     The Company has entered into employment  agreements (the "Agreements") with
Dr.  Hockmeyer,  Mr. Booth,  Mr. Mott,  Dr. Top, Mr.  Wright,  Dr. Young and Mr.
Dziurzynski  dated as of November 1, 1998.  The  Agreements  provide  that these
executives  will  serve the  Company  in the  respective  offices  listed in the
Summary  Compensation  Table for a term of two years  (such  period  subject  to
extension, with consent of the executives),  for one or more one-year periods by
resolution  adopted by the Compensation and Stock Committee,  subject to earlier
termination as provided in the Agreements.  The Agreements set forth the minimum
base salary of each executive  during the term of the  Agreements  ($450,000 for
Dr. Hockmeyer,  $425,000 for Mr. Booth,  $375,000 for Mr. Mott, $245,000 for Dr.
Top,  $245,000  for Mr.  Wright,  $245,000  for Dr.  Young and  $210,000 for Mr.
Dziurzynski),  with such base salary to be reviewed for possible  increase  each
year by the  Committee.  Under the  Agreements,  each executive (i) will have an
opportunity to earn an annual cash bonus based upon  pre-determined  performance
standards of the Company,  (ii) will be entitled to participate in such employee
benefit and fringe  benefit plans or programs as are made available from time to
time to similarly situated  executives of the Company and (iii) will be eligible
for the grant of stock  options,  as  determined  in the sole  discretion of the
Committee.

     The Agreements  include  provisions that are effective upon the termination
of employment of the executive  under certain  circumstances.  In the event that
such a termination by the Company constitutes a "termination  without cause" (as
defined  in the  Agreements),  he will be  entitled  to (i)  accrued  but unpaid
compensation and benefits, (ii) continued payment of base salary plus a pro rata
bonus amount for a period of two years (or one year in the cases of Dr. Top, Mr.
Wright, Dr. Young and Mr.  Dziurzynski) and (iii) continued benefit coverage for
two years (or one year in the cases of Dr. Top,  Mr.  Wright,  Dr. Young and Mr.
Dziurzynski).  In the event that the  executive  resigns or his  termination  of
employment constitutes a "termination for cause" (as defined in the Agreements),
he will be entitled  to accrued but unpaid  compensation  and  benefits.  In the
event the  executive  is  terminated  on  account of death or  "disability"  (as
defined  in the  Agreements),  he will be  entitled  to (i)  accrued  but unpaid
compensation  and  benefits,  (ii) a lump-sum  payment equal to one year of base
salary and (iii) in the case of  "disability,"  continuation  of medical benefit
coverage for one year.

     In the event of the termination of employment of the executive  constitutes
a "termination  without cause," or a resignation for "good reason,"  following a
"change in control" of the Company (such terms as defined in the Agreements), he
will be entitled to (i) accrued but unpaid compensation and benefits (ii) a lump
sum  payment  equal to his base salary (as in effect  immediately  prior to such
termination)  plus a pro rata bonus  amount for three years (or two years in the
cases of Dr. Top, Mr. Wright, Dr. Young and Mr. Dziurzynski) as set forth in the
Agreements,  discounted to present  value from the dates such payments  would be
made if paid on a  semi-monthly  basis and  (iii)  continuation  of the  medical
benefits  coverage for a period of three years (or two years in the cases of Dr.
Top,  Mr.  Wright,  Dr.  Young  and Mr.  Dziurzynski).  In the  event  that  Dr.
Hockmeyer's,  Mr. Booth's or Mr. Mott's termination of employment  constitutes a
"termination without cause" or a resignation for "good reason" within six months
following a "change in control" of the Company, such executives shall retain the
right to exercise any options to purchase  shares of the  Company's  stock until
the earlier of (a) three years following the date of such termination or (b) the
expiration  of the  original  full term of each  such  option.  Dr.  Hockmeyer's
Agreement also provides for lifetime  continuation of  Company-provided  medical
and dental  coverage as in effect from time to time for officers of the Company,
which  coverage  shall not be affected by any  termination  of employment at any
time for any reason.


                                       10

<PAGE>



     Upon a "change in control" of the Company,  all options to purchase Company
stock held by Dr.  Hockmeyer,  Mr.  Booth and Mr. Mott shall become fully vested
and exercisable.  In the event that any payment under the Agreements constitutes
an excess parachute payment under Section 280G of the Internal Revenue Code (the
"Code"),  the executive  will be entitled to additional  gross-up  payments such
that the net amount  retained by the  executive  after  deduction  of any excise
taxes and all other  taxes on the  gross-up  payments  shall be equal to the net
amount  that  would  have been  retained  from the  initial  payments  under the
Agreements.

     The Agreements include certain restrictive covenants for the benefit of the
Company  relating  to   non-disclosure   by  the  executives  of  the  Company's
confidential  business  information,  the  Company's  right  to  inventions  and
intellectual property,  nonsolicitation of the Company's employees and customers
and noncompetition by the executives with the Company's  business.  In the event
that, subsequent to termination of employment,  the executives breach any of the
restrictive  covenants  or  directly  or  indirectly  make  any  adverse  public
statements  or  disclosures  with respect to the business or  securities  of the
Company,  all payments and benefits to which the executives may otherwise be due
under the Agreements shall immediately terminate and be forfeited.

Director Compensation

     Other  than Dr.  Barrett,  Ms.  Franklin  and  Messrs.  Hoff  and  Macklin,
directors  receive no cash  compensation  for their  services  to the Company as
directors,  but are reimbursed for expenses actually incurred in connection with
attending meetings of the Board of Directors. As compensation for serving on the
Board, Dr. Barrett, Ms. Franklin, and Messrs. Hoff and Macklin receive an annual
retainer of $10,000,  a fee of $2,500 per Board meeting  attended in person plus
expenses and a fee of $1,000 for  participating  in a telephonic  Board meeting.
For attendance at meetings of Board  committees held on days when the Board does
not meet,  such  directors  receive  $1,000 per meeting  attended in person plus
expenses  and  $500  for  participating  by  telephone.  Directors  may  also be
compensated  for special  assignments  delegated by the Board of Directors.  The
Company also has a  Non-Employee  Directors  Stock Option Plan pursuant to which
options  for 20,000  shares  are  granted to each  non-employee  director,  upon
commencement of service on the Board,  and options for 10,000 shares are granted
to each  non-employee  director on June 30 of each year of continued  service on
the Board.


CERTAIN TRANSACTIONS

     In 1998,  the Company  entered into a loan  agreement with Melvin D. Booth,
President and Chief Operating Officer, through which Mr. Booth borrowed $100,000
from the Company.  This loan bears  interest at a rate of 5.06% per annum and is
payable in three annual  installments of principal and interest.  As long as Mr.
Booth remains employed by the Company, annual payments of principal and interest
will be  forgiven  by the  Company.  In the event that Mr.  Booth is  terminated
"without  cause" as defined in his employment  agreement,  all sums  outstanding
will be forgiven.


                                       11

<PAGE>



PERFORMANCE GRAPH

     Set  forth  below is a line  graph  based on  monthly  data  comparing  the
Company's  cumulative  total  shareholder  return (as  measured by dividing  the
difference between the Company's share price at the beginning and the end of the
measurement  period  by the  share  price at the  beginning  of the  measurement
period) with (i) the  cumulative  total return of The Nasdaq Stock Market (U.S.)
Index and (ii) the cumulative total return of the Nasdaq  Pharmaceutical  Stocks
Index.  The Company has selected the Nasdaq  Pharmaceutical  Stocks Index as the
appropriate  published  industry  index for this  comparison,  as this  Index is
comprised  of 260  companies,  of  which  a  large  majority  are  biotechnology
companies.


           COMPARISON OF 1994-1998 CUMMULATIVE SHAREHOLDER RETURN (1)
                               PERFORMANCE CHART

<TABLE>
<CAPTION>
                              Jan-94         Jul-94         Jan-95         Jul-95         Jan-96         Jul-96
<S>                           <C>            <C>            <C>            <C>            <C>            <C>   
Medimmune                     100.00         79.55          31.82          130.69         181.82         154.55
Nasdaq Pharmaceutical         100.00         71.19          75.26           94.77         138.04         139.53
NASDAQ(U.S.)                  100.00         91.32          97.75          121.91         138.26         156.51

<CAPTION>
                              Jan-97         Jul-97         Jan-98         Jul-98         Dec-98
<S>                           <C>            <C>            <C>            <C>            <C>   
Medimmune                     154.55         168.18         389.78         567.06         903.98
Nasdaq Pharmaceutical         138.47         141.97         142.98         145.67         183.02
NASDAQ(U.S.)                  170.02         190.27         208.58         251.12         293.21
</TABLE>




                                       12

<PAGE>



                 PROPOSAL 2 - APPROVAL OF 1999 STOCK OPTION PLAN

     Stock  options  have  been  an  integral  part of the  Company's  incentive
compensation program since the formation of the Company. The Board believes that
the  stockholders  have  benefited from employee stock options over the years as
options have enabled the Company to attract and retain employees who enhance the
value of the  Company  and  align  the  interests  of  employees  with  those of
stockholders  through increased employee ownership of the Company. The Company's
existing  employee  stock  option plan was adopted in 1991 (the "1991 Plan") and
expires  by its  terms in two  years.  The 1991  Plan  contains  limitations  on
flexibility  that  the  Board  no  longer  considers  necessary  (e.g.,  a total
prohibition on transferability of stock options and the requirement that options
could only be granted to existing rather than prospective employees, consultants
and certain others). Furthermore, as of March 31, 1999, only 2,882 shares remain
available for the grant of options under the 1991 Plan.  Accordingly,  the Board
has  adopted a new stock  option  plan (the  "1999  Plan")  which  would  become
effective  upon  approval by the  Company's  stockholders.  The  following  is a
general  description  of the 1999 Plan,  and is qualified in its entirety by the
full text of the 1999 Plan, which is attached to this Proxy Statement as Exhibit
A.

     Plan Description.  The purpose of the 1999 Plan is to advance the interests
of the Company and its stockholders by attracting,  retaining and motivating key
personnel upon whose judgment, initiative and effort the Company depends for the
successful conduct of its business,  and to encourage and enable such persons to
acquire a  proprietary  interest  in the  Company.  The 1999 Plan allows for the
grant of "incentive stock options"  qualified under section 422 of the Code, and
for the grant of nonqualified stock options.

     A total of 2,750,000  shares of the Company's common stock ("Common Stock")
have been  reserved for issuance  pursuant to options  under the 1999 Plan.  The
shares of Common Stock to be issued will be made available  from  authorized but
unissued shares or shares held in the Company's treasury. Shares of Common Stock
that  have  been  exercised  will not again be  available  for an option  grant.
However,  if an option terminates for any reason without being wholly exercised,
the number of shares to which the option termination  relates will again be made
available  for an option  grant  under the 1999  Plan.  In the event of  certain
corporate  reorganizations,  recapitalizations,  or  other  specified  corporate
transactions  affecting the Company or the Common  Stock,  the 1999 Plan permits
proportionate  adjustments  to the number and kinds of shares subject to options
and the exercise price of options.

     The 1999 Plan will be administered by the  Compensation and Stock Committee
of the Board.  To the extent the Board deems it  necessary  or  advisable,  each
Committee  member  will meet the  definition  of a  "nonemployee  director"  for
purposes of Rule 16b-3 under the Securities  Exchange Act of 1934 ("Rule 16b-3")
and of an "outside  director"  under section 162(m) of the Code.  Subject to the
limitations  set forth in the 1999 Plan,  the  Committee  has the  authority  to
determine  the persons to whom  options are granted,  the time at which  options
will be granted,  the number of shares subject to an option,  the exercise price
of an option,  the time or times at which the  options  will  become  vested and
exercisable,  and the duration of the option. The Committee will have the right,
from time to time,  to  delegate  to one or more  officers  of the  Company  the
authority of the Committee to grant and  determine  the terms and  conditions of
option grants,  subject to such  limitations as the Committee  shall  determine.
However,  no such  authority  may be  delegated  with  respect  to options to be
awarded to any member of the Board or any optionee whom the Committee determines
may be subject to Rule 16b-3 or section 162(m) of the Code. Furthermore,  option
grants to nonemployee members of the Board of the Company


                                       13

<PAGE>



must be approved  by the Board.  With  respect to awards to such  members of the
Board, all rights, powers and authorities vested in the Committee under the 1999
Plan must instead be exercised by the Board.

     All employees, officers, directors, consultants and advisors of the Company
or any subsidiary (and any prospective employee,  officer, director,  consultant
or advisor) are eligible to be granted  options under the 1999 Plan, as selected
from time to time by the Committee.  However,  only persons who are employees of
the Company are eligible to be granted an incentive stock option under the Code.

     The  exercise  price of an option  shall be  determined  by the  Committee,
provided that the exercise price per share may not be less than 100% of the fair
market  value of a share of  Common  Stock on the date of grant.  The  aggregate
value of Common Stock  (determined  at the time of grant) that may be subject to
incentive  stock options that become  exercisable by any one employee in any one
year is limited to $100,000 by section 422 of the Code.  For purposes of the tax
deduction  requirements  of section  162(m) of the Code,  the maximum  number of
shares of Common Stock that may be subject to all stock  options  granted  under
the 1999 Plan to any optionee  during any one calendar  year will be  1,000,000,
subject  to  adjustment  in the  event  of  certain  corporate  reorganizations,
recapitalizations or other specified corporate transactions. The maximum term of
options granted under the 1999 Plan is ten years from the date of grant.

     Options will become vested and exercisable in the manner and subject to the
conditions  approved by the  Committee  for  individual  grants and set forth in
stock option agreements.  However,  the Committee,  in its sole discretion,  may
accelerate the vesting and  exercisability of any option at any time,  including
upon a change in  control  of the  Company.  Unless  otherwise  provided  by the
Committee,  in the  event  of an  optionee's  death or  disability,  outstanding
options that have become exercisable will remain exercisable for a period of one
year.  In the case of any other  termination  of  employment,  unless  otherwise
provided by the  Committee,  outstanding  options  that have  previously  become
vested  will  remain  exercisable  for a period of three  months,  except  for a
termination  for  "cause"  (as  defined  in the 1999  Plan),  in which  case all
unexercised options will be immediately forfeited.

     An  option  may be  exercised  in whole  or in part at any  time  following
vesting during the term of the option by written notice to the Company, together
with  payment of the  aggregate  exercise  price of the option and any  required
withholding  tax.  Such  payment  shall be made in cash or,  at the  Committee's
discretion,  in Common Stock or in another form of payment  permitted  under the
1999  Plan.  All  options  shall be  nontransferable  except  upon  death by the
optionee's  will or the laws of descent  and  distribution  and,  in the case of
nonqualified  stock options only, to family  members of the optionee,  as may be
approved by the Committee in accordance with the terms of the 1999 Plan.

     The 1999 Plan has a term of ten years,  subject to earlier  termination  by
the Board.  The Board may at any time and from time to time and in any  respect,
amend or modify the Plan.  Solely to the extent deemed necessary or advisable by
the Board,  for purposes of complying with sections 422 or 162(m) of the Code or
rules of any securities exchange or for any other reason, the Board may seek the
approval  of any  such  amendment  by the  stockholders.  The  Committee  is not
permitted to reduce the exercise  price of stock options  previously  granted or
increase  the  number  of shares  issuable  pursuant  to the 1999  Plan  without
obtaining the approval of the Company's stockholders.

     Federal Income Tax Consequences.  The following is a general description of
federal income tax  consequences to optionees and the Company  relating to stock
options  granted under the 1999 Plan.  This discussion does not purport to cover
all tax consequences relating to the optionees or the Company.


                                       14

<PAGE>



     An  optionee  will not  generally  recognize  income  upon  the  grant of a
nonqualified  stock option to purchase shares of Common Stock.  Upon exercise of
the option, the optionee will generally  recognize ordinary  compensation income
equal to the excess of the fair market  value for such shares over the  exercise
price.  The tax basis of the shares of Common Stock in the hands of the optionee
will equal the  exercise  price paid for the shares  plus the amount of ordinary
compensation income the optionee recognizes upon exercise of the option, and the
holding  period for the shares for capital  gains  purposes will commence on the
day the option is exercised.  An optionee who sells any of such shares of Common
Stock will recognize capital gain or loss measured by the difference between the
tax basis of the shares and the amount realized on the sale. The Company will be
entitled to a  deduction  equal to the amount of  ordinary  compensation  income
recognized by the optionee.  The deduction  will be allowed at the same time the
optionee recognizes the income.

     An  optionee  will not  generally  recognize  income  upon the  grant of an
incentive stock option to purchase shares of Common Stock and will not generally
recognize  income  upon  exercise  of the option,  provided  the  optionee is an
employee  of the  Company  or a  subsidiary  at all times from the date of grant
until three  months  prior to  exercise.  However,  the amount by which the fair
market value of the shares of Common  Stock on the date of exercise  exceeds the
exercise price will be includable for purposes of  determining  any  alternative
minimum  taxable  income of an optionee.  Where an optionee who has exercised an
incentive  stock option sells the shares of Common Stock  acquired upon exercise
more than two years after the grant date and more than one year after  exercise,
capital  gain or loss will be  recognized  equal to the  difference  between the
sales price and the exercise  price. An optionee who sells such shares of Common
Stock  within two years  after the grant date or within one year after  exercise
will recognize ordinary  compensation income in an amount equal to the lesser of
the difference  between (a) the exercise price and the fair market value of such
shares  on the  date  of  exercise,  or (b) the  exercise  price  and the  sales
proceeds.  Any remaining gain or loss will be treated as a capital gain or loss.
The Company  will be  entitled  to a  deduction  equal to the amount of ordinary
compensation  income recognized by the optionee in this case. The deduction will
be allowable at the same time the optionee recognizes the income.

     Compensation of persons who are Named Executive  Officers of the Company is
subject to the tax deduction  limits of section 162(m) of the Code. Stock option
compensation that qualifies as  "performance-based  compensation" is exempt from
section  162(m),  thus  allowing  the Company the full tax  deduction  otherwise
permitted for such compensation. If approved by the Company's stockholders,  the
1999 Plan will enable the  Committee to grant stock  options that will be exempt
from the deduction limits of section 162(m) of the Code.



                                       15

<PAGE>



     1991 Plan and New Plan  Benefits.  During 1998,  stock options were granted
under the 1991 Plan to the Named Executive Officers as set forth in the table on
page 9 entitled  "Option  Grants in Fiscal  1998." The  Committee  granted stock
options  during 1998 under the 1991 Plan for  1,330,000  shares to all executive
officers as a group at an average  weighted  exercise  price of $26.25 per share
and  1,080,600  shares  to other  employees  as a group at an  average  weighted
exercise  price  of  $28.59  per  share.  The  Committee  has not yet  made  any
determinations as to grants of stock options under the 1999 Plan.

     The closing  price of the Common  Stock on the Nasdaq Stock Market on March
31, 1999 was $59.188 per share.


     THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE APPROVAL OF THE MEDIMMUNE,
INC. 1999 STOCK OPTION PLAN.


                PROPOSAL 3 - APPOINTMENT OF INDEPENDENT AUDITORS

     The Audit  Committee  recommended  and the Board of Directors  approved the
appointment of PricewaterhouseCoopers  L.L.P. as independent auditors for fiscal
1999, subject to stockholder approval and ratification.  The Audit Committee, in
arriving  at its  recommendation  to the  Board,  reviewed  the  performance  of
PricewaterhouseCoopers  L.L.P.  in prior years as well as the firm's  reputation
for integrity and competence in the fields of accounting and auditing. The Audit
Committee has expressed its satisfaction with  PricewaterhouseCoopers  L.L.P. in
these respects.

     PricewaterhouseCoopers  L.L.P.  has  served  as the  Company's  independent
auditor since the Company's inception. Representatives of PricewaterhouseCoopers
L.L.P.  will  be  present  at  the  stockholders'  meeting  and  will  have  the
opportunity  to make  such  statements  as they may  desire.  They  will also be
available to respond to appropriate questions from the stockholders present.


     THE  BOARD  OF  DIRECTORS  RECOMMENDS  A  VOTE  FOR  THE  APPROVAL  OF  THE
APPOINTMENT OF  PRICEWATERHOUSECOOPERS  L.L.P.  AS  INDEPENDENT  AUDITORS OF THE
COMPANY FOR THE YEAR 1999.



                                       16

<PAGE>



                               SECURITY OWNERSHIP


PRINCIPAL STOCKHOLDERS

     The  following  table sets forth  certain  information  at January 31, 1999
regarding the  beneficial  ownership of Common Stock of each person known by the
Company to be the beneficial  owner of more than five percent of the outstanding
Common Stock, each of the directors of the Company,  each of the Named Executive
Officers  and all Named  Executive  Officers  and  directors of the Company as a
group.


<TABLE>
<CAPTION>
                                                                                 BENEFICIAL OWNERSHIP
                                                                             -----------------------------
                                   NAME                                       NUMBER OF SHARES     PERCENT
- --------------------------------------------------------------------------   ------------------   --------
<S>                                                                          <C>                  <C>
BB Biotech AG ............................................................        7,786,000          14.2
 Vordergasse 3
 8200 Schaffhausen
 CH/Switzerland
FMR Corp. ................................................................        6,946,940          12.7
 82 Devonshire Street
 Boston, Massachusetts 02109
The Equitable Companies Incorporated(1) ..................................        4,629,168           8.3
 787 Seventh Avenue
 New York, New York 10019
Investor AB ..............................................................        3,238,000           5.9
 S-103 32
 Stockholm, Sweden
Wayne T. Hockmeyer, Ph.D.(2) .............................................          492,500            *
David M. Mott(2) .........................................................          385,078            *
Franklin H. Top, Jr., M.D.(2) ............................................          698,838           1.3
M. James Barrett, Ph.D.(2) ...............................................           35,000            *
James H. Cavanaugh, Ph.D.(3) .............................................           57,476            *
Barbara Hackman Franklin(2) ..............................................           34,500            *
Lawrence C. Hoff(2) ......................................................           10,400            *
Gordon S. Macklin(2) .....................................................           85,000            *
David P. Wright(2) .......................................................          100,654            *
James F. Young, Ph.D.(2) .................................................          402,610            *
Bogdan Dziurzynski(2) ....................................................           87,500            *
All executive officers and directors as a group (12 persons)(2)(3) .......        2,389,556           4.2
</TABLE>

- ----------
*    Less than one percent.

(1)  Includes  802,846  shares of Common Stock  issuable  upon  conversion of 7%
     Convertible  Notes due 2003 of MedImmune,  Inc.  beneficially  owned by The
     Equitable Companies Incorporated.

(2)  Includes  shares of Common Stock issuable upon exercise of options  vesting
     prior to April 2, 1999 as  follows:  Dr.  Hockmeyer,  492,500  shares:  Dr.
     Barrett,  35,000 shares;  Ms.  Franklin,  32,500 shares;  Mr. Hoff,  10,000
     shares;  Mr. Macklin,  55,000 shares;  Mr. Mott,  385,078 shares;  Dr. Top,
     466,872 shares; Mr. Wright 100,654 shares;  Dr. Young,  358,258 shares; Mr.
     Dziurzynski,  49,620 shares;  and all executive officers and directors as a
     group, 1,985,482 shares.

(3)  Includes  29,530 shares owned  directly by Dr.  Cavanaugh and 27,946 shares
     owned by a partnership of which Dr. Cavanaugh is a general partner.



                                       17

<PAGE>



                                  OTHER MATTERS

     The Board of Directors  of the Company  knows of no matters to be presented
at the Annual Meeting other than those described in this Proxy Statement.  Other
business  may  properly  come before the meeting  and, in that event,  it is the
intention of the Proxy Committee to vote as recommended by the Company.


PROXY SOLICITATION

     The cost of the  solicitation of proxies will be borne by the Company.  The
Company will request  brokerage  houses,  banks and other custodians or nominees
holding  stock in their  names for others to forward  proxy  materials  to their
customers  or  principals  who are the  beneficial  owners  of  shares  and will
reimburse  them for their  expenses in doing so. The Company  expects to solicit
proxies primarily by mail, but directors,  officers,  and other employees of the
Company may also solicit in person, by telephone,  by facsimile, or by mail. The
Company has retained MacKenzie  Partners,  Inc. to assist in the solicitation of
proxies.  MacKenzie  Partners,  Inc. will solicit proxies by personal interview,
telephone,  facsimile,  and  mail.  It is  anticipated  that  the fee for  those
services will not exceed $3,000 plus  reimbursement  of customary  out-of-pocket
expenses.


DEADLINE FOR SUBMISSION OF STOCKHOLDER
PROPOSALS FOR NEXT YEAR'S ANNUAL MEETING

     The proxy rules adopted by the Securities and Exchange  Commission  provide
that certain  stockholder  proposals must be included in the proxy statement for
the Company's  Annual Meeting.  For a proposal to be considered for inclusion in
next year's  proxy  statement,  it must be received by the Company no later than
December 1, 1999.

     The  Company's  Annual  Report to  Stockholders,  including  the  Company's
audited  financial  statements  for the year ended  December 31, 1998,  is being
mailed herewith to all stockholders of record.

     ALL  STOCKHOLDERS  ARE URGED TO COMPLETE,  SIGN AND RETURN THE ACCOMPANYING
PROXY CARD IN THE ENCLOSED ENVELOPE.


                                        By Order of the Board of Directors,

                                        /s/ Carol A. Iorio

                                        Carol A. Iorio
                                        Corporate Secretary



35 West Watkins Mill Road
Gaithersburg, Maryland 20878
April 16, 1999


                                       18

<PAGE>



                                                                       EXHIBIT A







- --------------------------------------------------------------------------------






                                MEDIMMUNE, INC.
                             1999 STOCK OPTION PLAN






- --------------------------------------------------------------------------------



<PAGE>



                                TABLE OF CONTENTS


                                                                            PAGE
                                                                            ----

Article I. PURPOSE ........................................................  A-3
Article II. DEFINITIONS ...................................................  A-3
Article III. ELIGIBILITY ..................................................  A-4
Article IV. ADMINISTRATION ................................................  A-4
 Section 4.1 Committee Members ............................................  A-4
 Section 4.2 Committee Authority ..........................................  A-4
 Section 4.3 Delegation of Authority ......................................  A-5
 Section 4.4 Grants to Non-Employee Members of the Board ..................  A-5
Article V.  SHARES OF STOCK SUBJECT TO PLAN ...............................  A-5
 Section 5.1 Number of Shares .............................................  A-5
 Section 5.2 Adjustments ..................................................  A-5
Article VI. OPTIONS .......................................................  A-6
 Section 6.1 Grant of Option ..............................................  A-6
 Section 6.2 Maximum Limit ................................................  A-6
 Section 6.3 Option Price .................................................  A-6
 Section 6.4 Vesting; Term of Option ......................................  A-6
 Section 6.5 Option Exercise; Withholding .................................  A-6
 Section 6.6 Limited Transferability of Option ............................  A-7
 Section 6.7 Cancellation, Substitution and Amendment of Options ..........  A-7
Article VII. ADDITIONAL RULES FOR ISOs ....................................  A-8
 Section 7.1 Annual Limits ................................................  A-8
 Section 7.2 Termination of Employment ....................................  A-8
 Section 7.3 Other Terms and Conditions; Nontransferability ...............  A-8
 Section 7.4 Disqualifying Dispositions ...................................  A-8
Article VIII. TERMINATION OF SERVICE ......................................  A-8
 Section 8.1 Death ........................................................  A-8
 Section 8.2 Disability ...................................................  A-9
 Section 8.3 Termination for Cause ........................................  A-9
 Section 8.4 Other Termination of Service .................................  A-9
Article IX. STOCK CERTIFICATES ............................................  A-9
 Section 9.1 Issuance of Certificates .....................................  A-9
 Section 9.2 Conditions ................................................... A-10
 Section 9.3 Legends ...................................................... A-10
Article X. EFFECTIVE DATE, TERMINATION AND AMENDMENT ...................... A-10
 Section 10.1 Effective Date; Stockholder Approval ........................ A-10
 Section 10.2 Termination ................................................. A-10
 Section 10.3 Amendment ................................................... A-10
Article XI. MISCELLANEOUS ................................................. A-11
 Section 11.1 Employment or Other Service ................................. A-11
 Section 11.2 Rights as Stockholder ....................................... A-11
 Section 11.3 Other Compensation and Benefit Plans ........................ A-11
 Section 11.4 Plan Binding on Successors .................................. A-11
 Section 11.6 Severability ................................................ A-11
 Section 11.7 Governing Law ............................................... A-11



                                       A-2

<PAGE>



                                MEDIMMUNE, INC.

                             1999 STOCK OPTION PLAN



                                   ARTICLE I

                                    PURPOSE

     This  MedImmune,  Inc.  1999 Stock  Option  Plan is intended to advance the
interests  of the Company and its  stockholders  by  attracting,  retaining  and
motivating  key  personnel of the Company upon whose  judgment,  initiative  and
effort the  Company  is  largely  dependent  for the  successful  conduct of its
business,  and to  encourage  and enable such  persons to acquire a  proprietary
interest in the Company by ownership  of its stock.  Options  granted  under the
Plan may either be "incentive  stock options"  intended to qualify as such under
the Internal  Revenue  Code,  or  "nonqualified  stock  options,"  which are not
intended to so qualify.


                                  ARTICLE II

                                  DEFINITIONS

          (a) "Board" means the Board of Directors of the Company.

          (b) "Code" means the Internal Revenue Code of 1986, as amended.

          (c) "Common  Stock" means the Company's  Common Stock,  par value $.01
     per share.

          (d)  "Committee"  means the  Compensation  and Stock  Committee of the
     Board  or any  other  committee  of the  Board  appointed  by the  Board to
     administer the Plan from time to time.

          (e) "Company" means MedImmune, Inc., a Delaware corporation.

          (f)  "Date  of  Grant"  means  the date on  which  an  Option  becomes
     effective in accordance with Section 6.1 hereof.

          (g) "Eligible  Person"  means any person who is an employee,  officer,
     member  of  the  Board,  consultant  or  advisor  of  the  Company  or  any
     Subsidiary,  or any  person  who is  determined  by the  Committee  to be a
     prospective employee,  officer,  member of the Board, consultant or advisor
     of the Company or any Subsidiary.

          (h)  "Employee"  means any person who is an employee of the Company or
     any  Subsidiary;  provided,  however,  that with respect to Incentive Stock
     Options,  "Employee"  means any person who is considered an employee of the
     Company  or  any   Subsidiary   for   purposes   of   Treasury   Regulation
     (section)1.421-7(h).

          (i)  "Exchange  Act" means the  Securities  Exchange  Act of 1934,  as
     amended.

          (j) "Fair Market  Value" of a share of Common Stock as of a given date
     means the  closing  sales  price of the Common  Stock on the  Nasdaq  Stock
     Market, Inc. on the trading day immediately  preceding the date as of which
     Fair Market  Value is to be  determined  or, in the absence of any reported
     sales of Common Stock on such date,  on the first  preceding  date on which
     any such sale


                                       A-3

<PAGE>



     shall have been reported. If Common Stock is not listed on the Nasdaq Stock
     Market, Inc. on the date as of which Fair Market Value is to be determined,
     the  Committee  shall  determine  in good  faith the Fair  Market  Value in
     whatever manner it considers appropriate.

          (k)  "Incentive  Stock Option" means a stock option  granted under the
     Plan that is intended to meet the  requirements  of section 422 of the Code
     and the regulations promulgated thereunder.

          (l) "Nonqualified Stock Option" means a stock option granted under the
     Plan that is not an Incentive Stock Option.

          (m) "Option" means an Incentive  Stock Option or a Nonqualified  Stock
     Option granted under the Plan.

          (n)  "Optionee"  means an  Eligible  Person to whom an Option has been
     granted, which Option has not expired, under the Plan.

          (o) "Option Price" means the price at which each share of Common Stock
     subject  to an Option  may be  purchased,  determined  in  accordance  with
     Section 6.3 hereof.

          (p) "Plan" means this MedImmune, Inc. 1999 Stock Option Plan.

          (q) "Stock Option  Agreement"  means an agreement  between the Company
     and an Optionee  under which the Optionee  may purchase  Common Stock under
     the Plan.

          (r) "Subsidiary" means a subsidiary corporation of the Company, within
     the meaning of section 424(f) of the Code.


                                   ARTICLE III

                                   ELIGIBILITY

     All Eligible Persons are eligible to receive a grant of an Option under the
Plan. The Committee shall, in its sole discretion,  determine and designate from
time to time those Eligible Persons who are to be granted an Option.


                                   ARTICLE IV

                                 ADMINISTRATION

     Section  4.1  Committee  Members.  The  Plan  shall  be  administered  by a
Committee  comprised of no fewer than two persons selected by the Board.  Solely
to the extent deemed necessary or advisable by the Board,  each Committee member
shall meet the definition of a "nonemployee  director" for purposes of such Rule
16b-3 under the Exchange Act and of an "outside  director"  under section 162(m)
of the Code.  The Board shall also have the authority to exercise the powers and
duties of the Committee under the Plan.

     Section 4.2 Committee  Authority.  Subject to the express provisions of the
Plan, the Committee shall have the authority,  in its  discretion,  to determine
the Eligible  Persons to whom an Option  shall be granted,  the time or times at
which an Option shall be granted, the number of shares of Common Stock


                                       A-4

<PAGE>



subject to each Option,  the Option  Price of the shares  subject to each Option
and the time or times when each Option shall become exercisable and the duration
of the  exercise  period.  Subject to the express  provisions  of the Plan,  the
Committee  shall also have  discretionary  authority to interpret  the Plan,  to
prescribe,  amend and rescind rules and regulations relating to it, to determine
the   provisions  of  each  Stock  Option   Agreement,   and  to  make  all  the
determinations  necessary or advisable in the  administration  of the Plan.  All
such actions and  determinations by the Committee shall be conclusively  binding
for all purposes and upon all persons.  No Committee  member shall be liable for
any action or  determination  made in good faith with  respect to the Plan,  any
Option or any Stock Option Agreement entered into hereunder.

     Section 4.3  Delegation of Authority.  The Committee  shall have the right,
from time to time,  to  delegate  to one or more  officers  of the  Company  the
authority of the Committee to grant and  determine  the terms and  conditions of
Options  awarded under the Plan,  subject to such  limitations  as the Committee
shall determine; provided, however, that no such authority may be delegated with
respect to Options  awarded to any Optionee who the Committee  determines may be
subject to Rule 16b-3 under the Exchange Act or section 162(m) of the Code.

     Section 4.4 Grants to Non-Employee  Members of the Board. Awards of Options
to  non-employee  members of the Board  under the Plan shall be  approved by the
Board.  With  respect  to awards  to such  directors,  all  rights,  powers  and
authorities vested in the Committee under the Plan shall instead be exercised by
the Board,  and all  provisions of the Plan  relating to the Committee  shall be
interpreted  in a manner  consistent  with the  foregoing  by treating  any such
reference as a reference to the Board for such purpose.


                                    ARTICLE V

                         SHARES OF STOCK SUBJECT TO PLAN

     Section  5.1  Number of  Shares.  Subject  to  adjustment  pursuant  to the
provisions  of Section 5.2 hereof,  the  maximum  aggregate  number of shares of
Common Stock which may be issued and sold hereunder  shall be 2,750,000  shares.
Shares of Common Stock  issued and sold under the Plan may be either  authorized
but  unissued  shares or shares held in the  Company's  treasury.  The number of
shares of Common Stock  reserved for issuance under the Plan shall at no time be
less  than the  maximum  number of shares  which  may be  purchased  at any time
pursuant to  outstanding  options.  Shares of Common Stock  covered by an Option
that shall have been exercised shall not again be available for an Option grant.
If an Option  shall  terminate  or expire for any reason  without  being  wholly
exercised,  the number of shares to which such Option  termination or expiration
relates shall again be available for grant hereunder.

     Section 5.2  Adjustments.  In the event that the number of shares of Common
Stock of the Company shall be increased or decreased  through  reclassification,
combination  of  shares,  stock  split or the  payment of a stock  dividend,  or
otherwise,  then (i) the number of shares of Common Stock  currently  subject to
Options and the Option Prices of such Options, (ii) the maximum aggregate number
and kind of shares of Common  Stock  that may be issued and sold under the Plan,
and (iii) the maximum number of shares that may be subject to Options granted to
any Optionee during any one calendar year, shall be proportionately  adjusted to
reflect such increase or decrease.


                                       A-5

<PAGE>



     In the event there  shall be any other  change in the number or kind of the
outstanding  shares  of  Common  Stock  of the  Company,  or any  stock or other
securities into which such Common Stock shall have been changed, or for which it
shall  have  been  exchanged,  whether  by reason of  merger,  consolidation  or
otherwise,  then if the Committee shall, in its sole discretion,  determine that
such  change  equitably  requires  an  adjustment  to (i) the number and kind of
shares of Common  Stock  currently  subject to Options and the Option  Prices or
terms of such Options,  (ii) the maximum  aggregate number and kind of shares of
Common  Stock that may be issued and sold under the Plan,  and (iii) the maximum
number of shares of Common  Stock that may be subject to Options  granted to any
Optionee  during any one calendar year,  such  adjustments  shall be made in the
manner that the  Committee  shall deem to be equitable  and  appropriate.  In no
event may any such  change be made to an  Incentive  Stock  Option  which  would
constitute a "modification"  within the meaning of section 424(h)(3) of the Code
without  the  consent  of any  affected  Optionee.  In the event of any  merger,
consolidation,  reorganization or similar corporate event in which shares of the
Common Stock are to be exchanged for payment of cash (the "Cash Consideration"),
the Committee may, in its discretion, (i) make equitable adjustments as provided
above, or (ii) cancel any outstanding Option in exchange for payment in cash, if
any,  equal to the excess of the Cash  Consideration  for the shares  underlying
such Option over the Option Price for such shares.


                                   ARTICLE VI

                                     OPTIONS

     Section  6.1 Grant of Option.  An Option  may be  granted  to any  Eligible
Person  selected  by the  Committee.  The  grant  of an  Option  shall  first be
effective  upon the date it is approved by the  Committee,  except to the extent
the Committee shall specify a later date upon which the grant of an Option shall
first be effective.  Each Option shall be  designated,  at the discretion of the
Committee,  as  an  Incentive  Stock  Option  or a  Nonqualified  Stock  Option;
provided,  however, that Incentive Stock Options may only be granted to Eligible
Persons who are  Employees  of the Company.  The Company and the Optionee  shall
execute a Stock Option Agreement which shall set forth such terms and conditions
of the Option as may be determined  by the  Committee to be consistent  with the
Plan, and which may include additional  provisions and restrictions that are not
inconsistent with the Plan.

     Section 6.2 Maximum Limit.  Notwithstanding  anything elsewhere in the Plan
to the  contrary,  the  maximum  number of shares  of Common  Stock  that may be
subject to Options granted to any Optionee during any one calendar year shall be
1,000,000 shares, subject to adjustment as provided in Section 5.2 hereof.

     Section  6.3 Option  Price.  The Option  Price shall be  determined  by the
Committee;  provided, however, that the Option Price shall not be less than 100%
of the Fair Market Value of a share of Common Stock on the Date of Grant.

     Section  6.4  Vesting;  Term of  Option.  An Option  shall  vest and become
exercisable  in the  manner  and  subject  to such  conditions  provided  by the
Committee and set forth in the Stock Option  Agreement.  The  Committee,  in its
sole discretion,  may accelerate the  exercisability  of any Option at any time.
The period during which a vested Option may be exercised  shall be determined by
the Committee, subject to


                                       A-6

<PAGE>



a maximum term of ten years from the Date of Grant and such other limitations as
may apply upon the  termination of an Optionee's  employment or other service or
as otherwise specified by the Committee in the Stock Option Agreement.

     Section  6.5  Option  Exercise;  Withholding.  Subject  to such  terms  and
conditions as shall be specified in a Stock Option  Agreement,  an Option may be
exercised  in whole or in part at any time,  with  respect to whole shares only,
within the period permitted for the exercise thereof,  and shall be exercised by
written  notice of intent to  exercise  the Option  with  respect to a specified
number of shares delivered to the Company at its principal  office,  and payment
in full to the Company at said office of the amount of the Option  Price for the
number of shares of the Common  Stock  with  respect to which the Option is then
being  exercised.  Payment of the Option  Price  shall be made (i) in cash or by
cash equivalent,  (ii) at the discretion of the Committee,  in Common Stock that
has been held by the  Optionee  for at least six months (or such other period as
the Committee may deem appropriate for purposes of applicable accounting rules),
valued  at the  Fair  Market  Value  of such  shares  determined  on the date of
exercise,  (iii) at the discretion of the  Committee,  by a delivery of a notice
that the Optionee has placed a market sell order (or similar instruction) with a
broker with respect to shares of Common Stock then issuable upon exercise of the
Option, and that the broker has been directed to pay a sufficient portion of the
net  proceeds of the sale to the  Company in  satisfaction  of the Option  Price
(conditioned  upon the payment of such net proceeds),  (iv) at the discretion of
the Committee,  by a combination of the methods  described above, or (v) by such
other  method as may be  approved  by the  Committee  and set forth in the Stock
Option Agreement. In addition to and at the time of payment of the Option Price,
the  Optionee  shall pay to the Company the full amount of all federal and state
withholding  and other  employment  taxes  required to be withheld in connection
with such exercise, in any manner consistent with the foregoing that is approved
by the Committee and set forth in the Stock Option Agreement.

     Section  6.6  Limited  Transferability  of  Option.  All  Options  shall be
nontransferable  except (i) upon the Optionee's death, by the Optionee's will or
the laws of descent  and  distribution  or (ii) in the case  Nonqualified  Stock
Options only, on a case-by-case basis as may be approved by the Committee in its
discretion,  in  accordance  with  the  terms  provided  below.  A Stock  Option
Agreement for a Nonqualified Stock Option may provide that the Optionee shall be
permitted  to,  during his or her lifetime and subject to the prior  approval of
the  Committee  at the time of proposed  transfer,  transfer  all or part of the
Option to the Optionee's family member (as defined in the Stock Option Agreement
in a manner  consistent  with  the  requirements  for the Form S-8  registration
statement,  if applicable).  Any such transfer shall be subject to the condition
that it is made by the  Optionee for estate  planning,  tax planning or donative
purposes, and no consideration (other than nominal consideration) is received by
the  Optionee  therefor.  The  transfer of a  Nonqualified  Stock  Option may be
subject  to  such  other  terms  and  conditions  as  the  Committee  may in its
discretion  impose from time to time,  including a condition that the portion of
the Option to be  transferred  be vested and  exercisable by the Optionee at the
time of the  transfer.  Subsequent  transfers of an Option  shall be  prohibited
other than by will or the laws of descent and distribution upon the death of the
transferee.

     Section 6.7  Cancellation,  Substitution  and  Amendment  of  Options.  The
Committee shall have the authority to effect, at any time and from time to time,
with the consent of the affected  Optionees,  (i) the cancellation of any or all
outstanding  Options  and the  grant in  substitution  therefor  of new  Options
covering the same or  different  numbers of shares of Common Stock and having an
Option Price which may be the same as or different  than the Option Price of the
cancelled  Options or (ii) the amendment of the terms of any and all outstanding
Options; provided, however, that the Committee shall not, without


                                       A-7

<PAGE>



the approval of the Company's stockholders, cause the cancellation, substitution
or  amendment  of Options  that would have the effect of reducing  the  exercise
price of Options  previously  granted under the Plan, other than as permitted by
Section 5.2 hereof.


                                   ARTICLE VII

                            ADDITIONAL RULES FOR ISO

     Section 7.1 Annual Limits. No Incentive Stock Option shall be granted to an
Optionee as a result of which the aggregate Fair Market Value  (determined as of
the date of grant) of the stock with respect to which  "incentive stock options"
are  exercisable  for the first time in any calendar year under the Plan and any
other  stock  option  plans  of the  Company,  any  Subsidiary,  or  any  parent
corporation,  would exceed the maximum amount  permitted under section 422(d) of
the Code. This limitation shall be applied by taking options into account in the
order in which granted.

     Section 7.2  Termination  of  Employment.  An  Incentive  Stock  Option may
provide that such Option may be exercised not later than three months  following
termination of employment of the Optionee with the Company and all Subsidiaries,
subject to special rules relating to death and disability,  as and to the extent
determined by the Committee to be consistent  with the  requirements  of section
422 of the Code and Treasury Regulations thereunder.

     Section 7.3 Other Terms and Conditions;  Nontransferability.  Any Incentive
Stock  Option  granted   hereunder  shall  contain  such  additional  terms  and
conditions,  not  inconsistent  with  the  terms  of this  Plan,  as are  deemed
necessary or desirable by the Committee, which terms, together with the terms of
this Plan,  shall be intended  and  interpreted  to cause such  Incentive  Stock
Option to qualify as an "incentive  stock option" under section 422 of the Code.
Such terms shall include, if applicable,  limitations on Incentive Stock Options
granted to  ten-percent  owners of the  Company  as  determined  under  sections
422(b)(6)  and 424(d) of the Code.  A Stock  Option  Agreement  for an Incentive
Stock  Option may provide  that such Option  shall be treated as a  Nonqualified
Stock Option to the extent that certain  requirements  applicable  to "incentive
stock options" under the Code shall not be satisfied.  An Incentive Stock Option
shall by its terms be  nontransferable  otherwise than by will or by the laws of
descent and  distribution,  and shall be  exercisable  during the lifetime of an
Optionee only by such Optionee.

     Section 7.4 Disqualifying Dispositions.  If shares of Common Stock acquired
by  exercise  of an  Incentive  Stock  Option are  disposed  of within two years
following the Date of Grant or one year following the transfer of such shares to
the  Optionee  upon  exercise,  the  Optionee  shall,  promptly  following  such
disposition,  notify  the  Company  in  writing  of the date  and  terms of such
disposition and provide such other information  regarding the disposition as the
Committee may reasonably require.


                                  ARTICLE VIII

                             TERMINATION OF SERVICE

     Section 8.1 Death. Unless otherwise provided by the Committee and set forth
in the Stock Option  Agreement,  if an Optionee  shall die at any time after the
Date of Grant and while he is an Eligible Person,  the executor or administrator
of the estate of the decedent, or the person or persons to whom an


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Option shall have been validly transferred in accordance with Section 6.6 hereof
pursuant to will or the laws of descent and distribution,  shall have the right,
during  the  period  ending  one year  after  the date of the  Optionee's  death
(subject to the term of the Option),  to exercise the  Optionee's  Option to the
extent that it was exercisable at the date of the Optionee's death and shall not
have been previously exercised. The Committee may determine at or after grant to
make any portion of the Optionee's Option that is not exercisable at the date of
death immediately vested and exercisable.

     Section 8.2 Disability.  Unless otherwise provided by the Committee and set
forth in the  Stock  Option  Agreement,  if an  Optionee's  employment  or other
service with the Company or any  Subsidiary  shall be  terminated as a result of
permanent and total  disability  (within the meaning of section  22(e)(3) of the
Code) at any time after the Date of Grant and while the  Optionee is an Eligible
Person,   the   Optionee  (or  in  the  case  of  an  Optionee  who  is  legally
incapacitated,  his  guardian  or legal  representative)  shall  have the right,
during a period ending one year after the date of his disability (subject to the
term of the Option), to exercise an Option to the extent that it was exercisable
at the date of such  termination  of  employment  or other service and shall not
have been  exercised.  The Committee may determine at or after grant to make any
portion  of the  Optionee's  Option  that  is not  exercisable  at the  date  of
termination of employment or other service due to disability  immediately vested
and exercisable.

     Section  8.3  Termination  for  Cause.  Unless  otherwise  provided  by the
Committee  and  set  forth  in the  Stock  Option  Agreement,  if an  Optionee's
employment  or  other  service  with  the  Company  or any  Subsidiary  shall be
terminated for cause, the Optionee's  right to exercise any unexercised  portion
of an Option shall immediately  terminate and all rights thereunder shall cease.
For purposes of this Section 8.3, termination for "cause" shall include, but not
be limited to,  embezzlement or misappropriation of corporate funds, any acts of
dishonesty  resulting  in  conviction  for a  felony,  misconduct  resulting  in
material injury to the Company or any Subsidiary, significant activities harmful
to the reputation of the Company or any Subsidiary,  a significant  violation of
Company or  Subsidiary  policy,  willful  refusal  to  perform,  or  substantial
disregard of, the duties  properly  assigned to the  Optionee,  or a significant
violation  of any  contractual,  statutory  or common law duty of loyalty to the
Company  or any  Subsidiary.  Notwithstanding  the  foregoing,  in the  event an
Optionee is party to an employment  (or similar)  agreement  with the Company or
any Subsidiary  that defines the term "cause," such  definition  shall apply for
purpose of the Plan. The Committee shall have the power to determine whether the
Optionee has been terminated for cause and the date upon which such  termination
for cause occurs. Any such determination shall be final,  conclusive and binding
upon the Optionee.

     Section 8.4 Other Termination of Service.  Unless otherwise provided by the
Committee  and  set  forth  in the  Stock  Option  Agreement,  if an  Optionee's
employment  or  other  service  with  the  Company  or any  Subsidiary  shall be
terminated  for any reason other than death,  permanent and total  disability or
termination  for cause,  the  Optionee  shall have the right,  during the period
ending three months after such termination  (subject to the term of the Option),
to exercise an Option to the extent that it was  exercisable at the date of such
termination and shall not have been exercised. For purposes of this Section 8.4,
an Optionee  shall not be  considered  to have  terminated  employment  or other
service with the Company or any Subsidiary until the expiration of the period of
any  military,  sick leave or other bona fide leave of absence,  up to a maximum
period  of 90 days  (or  such  greater  period  during  which  the  Optionee  is
guaranteed reemployment either by statute or contract).


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                                   ARTICLE IX

                               STOCK CERTIFICATES

     Section 9.1 Issuance of  Certificates.  Subject to Section 9.2 hereof,  the
Company  shall issue a stock  certificate  in the name of the Optionee (or other
person  exercising the Option in accordance with the provisions of the Plan) for
the  shares  of  Common  Stock  purchased  by  exercise  of an Option as soon as
practicable  after due  exercise and payment of the  aggregate  Option Price for
such shares. A separate stock certificate or separate stock  certificates  shall
be issued for any shares of Common Stock  purchased  pursuant to the exercise of
an Option that is an Incentive Stock Option,  which  certificate or certificates
shall not include any shares of Common Stock that were purchased pursuant to the
exercise of an Option that is a Nonqualified Stock Option.

     Section  9.2  Conditions.  The  Company  shall not be  required to issue or
deliver any  certificate  for shares of Common Stock purchased upon the exercise
of any Option granted  hereunder or any portion  thereof prior to fulfillment of
all of the following conditions:

          (i) the completion of any registration or other  qualification of such
     shares,  under any federal or state law or under the rulings or regulations
     of  the  Securities  and  Exchange  Commission  or any  other  governmental
     regulatory  body,  that the  Committee  shall in its sole  discretion  deem
     necessary or advisable;

          (ii) the obtaining of any approval or other clearance from any federal
     or  state  governmental  agency  which  the  Committee  shall  in its  sole
     discretion determine to be necessary or advisable;

          (iii)  the  lapse of such  reasonable  period  of time  following  the
     exercise of the Option as the Committee from time to time may establish for
     reasons of administrative convenience;

          (iv) satisfaction by the Optionee of all applicable  withholding taxes
     or other withholding liabilities; and

          (v) if required by the Committee, in its sole discretion,  the receipt
     by the Company from an Optionee of (i) a representation in writing that the
     shares  of Common  Stock  received  upon  exercise  of an Option  are being
     acquired for investment and not with a view to  distribution  and (ii) such
     other  representations and warranties as are deemed necessary by counsel to
     the Company.

     Section  9.3  Legends.  The  Company  reserves  the  right  to  legend  any
certificate for shares of Common Stock,  conditioning  sales of such shares upon
compliance with applicable federal and state securities laws and regulations.


                                    ARTICLE X

                    EFFECTIVE DATE, TERMINATION AND AMENDMENT

     Section 10.1 Effective Date;  Stockholder  Approval.  The Plan shall become
effective on the date of its approval by the stockholders of the Company,  which
approval  shall be obtained  within 12 months  after the adoption of the Plan by
the Board.


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     Section 10.2 Termination.  The Plan shall terminate on the date immediately
preceding  the tenth  anniversary  of the date the Plan is adopted by the Board.
The Board may, in its sole  discretion  and at any earlier  date,  terminate the
Plan.  Notwithstanding  the  foregoing,  no termination of the Plan shall in any
manner affect any Option theretofore granted without the consent of the Optionee
or the permitted transferee of the Option.

     Section 10.3 Amendment. The Board may at any time and from time to time and
in any respect,  amend or modify the Plan. Solely to the extent deemed necessary
or advisable by the Board, for purposes of complying with sections 422 or 162(m)
of the Code or rules of any  securities  exchange or for any other  reason,  the
Board may seek the approval of any such amendment by the Company's stockholders.
Notwithstanding the foregoing, no amendment or modification of the Plan shall in
any manner  affect any Option  theretofore  granted  without  the consent of the
Optionee or the permitted transferee of the Option.


                                   ARTICLE XI

                                  MISCELLANEOUS

     Section 11.1 Employment or Other Service. Nothing in the Plan, in the grant
of any Option or in any Stock  Option  Agreement  shall confer upon any Eligible
Person the right to  continue  in the  capacity  in which he is  employed  by or
otherwise  provides  services to the Company or any Subsidiary.  Notwithstanding
anything  contained in the Plan to the contrary,  unless otherwise provided in a
Stock Option  Agreement,  no Option shall be affected by any change of duties or
position  of the  Optionee  (including  a transfer to or from the Company or any
Subsidiary), so long as such Optionee continues to be an Eligible Person.

     Section 11.2 Rights as Stockholder. An Optionee or the permitted transferee
of an Option  shall have no rights as a  stockholder  with respect to any shares
subject to such Option  prior to the purchase of such shares by exercise of such
Option as  provided  herein.  Nothing  contained  herein or in the Stock  Option
Agreement  relating to any Option shall create an  obligation on the part of the
Company to repurchase any shares of Common Stock purchased hereunder.

     Section 11.3 Other Compensation and Benefit Plans. The adoption of the Plan
shall not affect any other stock option or incentive or other compensation plans
in effect for the Company or any  Subsidiary,  nor shall the Plan  preclude  the
Company from establishing any other forms of incentive or other compensation for
employees  of the  Company or any  Subsidiary.  The  amount of any  compensation
deemed to be received by an Optionee as a result of the exercise of an Option or
the sale of shares received upon such exercise shall not constitute compensation
with  respect  to  which  any  other  employee  benefits  of such  Optionee  are
determined,  including,  without limitation,  benefits under any bonus, pension,
profit sharing,  life insurance or salary continuation plan, except as otherwise
specifically  determined  by the Board or the Committee or provided by the terms
of such plan.

     Section 11.4 Plan Binding on Successors. The Plan shall be binding upon the
Company,   its  successors  and  assigns,   and  the  Optionee,   his  executor,
administrator and permitted transferees.

     Section 11.5 Construction and Interpretation.  Whenever used herein,  nouns
in the  singular  shall  include the plural,  and the  masculine  pronoun  shall
include  the  feminine  gender.  Headings of Articles  and  Sections  hereof are
inserted for convenience and reference and constitute no part of the Plan.


                                      A-11

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     Section 11.6 Severability. If any provision of the Plan or any Stock Option
Agreement shall be determined to be illegal or unenforceable by any court of law
in any  jurisdiction,  the  remaining  provisions  hereof and  thereof  shall be
severable and  enforceable  in accordance  with their terms,  and all provisions
shall remain enforceable in any other jurisdiction.

     Section 11.7 Governing Law. The validity and  construction of this Plan and
of the Stock  Option  Agreements  shall be  governed by the laws of the State of
Delaware.






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                         [MEDIMMUNE, INC. LOGO OMITTED]



                                 MEDIMMUNE, INC.














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