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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
SCHEDULE 13G
(Amendment No. 5)*
UNDER THE SECURITIES EXCHANGE ACT OF 1934
Isis Pharmaceuticals, Inc.
(Name of Issuer)
Common Stock
(Title of Class of Securities)
464330 10 9
(CUSIP Number)
*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
Page 1 of 4 pages
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13G
CUSIP NO. 464330 10 9 PAGE 2 OF 4 PAGES
1 NAME OF REPORTING PERSONS
S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS
STANLEY T. CROOKE ###-##-####
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [X]
3 SEC USE ONLY
4 CITIZENSHIP OR PLACE OF ORGANIZATION
UNITED STATES
5 SOLE VOTING POWER
NUMBER OF 1,209,519 (1)
SHARES 6 SHARED VOTING POWER
BENEFICIALLY OWNED BY 0
EACH REPORTING PERSON WITH 7 SOLE DISPOSITIVE POWER
1,209,519 (1)
8 SHARED DISPOSITIVE POWER
0
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,209,519 (1)
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
4.6%
12 TYPE OF REPORTING PERSON*
IN
(1) includes 93,974 shares of Common Stock issuable upon exercise of options
exercisable within 60 days. Also includes 6,045 shares issuable upon exercise of
stock options held by Rosanne Crooke, Dr. Crooke's wife, exercisable on or
before 3/1/97, as to which Dr. Crooke disclaims beneficial ownership.
*SEE INSTRUCTION BEFORE FILLING OUT!
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ITEM 1.
(a) Name of Issuer: Isis Pharmaceuticals, Inc. ("Issuer")
(b) Address of Issuer's Principal Executive Offices: 2292 Faraday Avenue
Carlsbad, CA 92008
ITEM 2.
(a) Name of Person Filing: Stanley T. Crooke
(b) Address of Principal Business Office or, if none,
Residence: 2292 Faraday Avenue
Carlsbad, CA 92008
(c) Citizenship: United States
(d) Title of Class of Securities: Common Stock
(e) CUSIP Number: 464330 10 9
ITEM 3. NOT APPLICABLE.
ITEM 4. OWNERSHIP.
(a) Amount Beneficially Owned: 1,209,519 (2)
(b) Percent of Class: 4.6%
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote: 1,209,519 (2)
(ii) shares power to vote or to direct the vote: 0
(iii) sole power to dispose or to direct the disposition of: 1,209,519 (2)
(iv) shared power to dispose or to direct the disposition of:0
ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS
If this statement is being filed to report the fact that as of the date hereof
the reporting person has ceased to be the beneficial owner of more than five
percent of the class of securities, check the
following: [X]
ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON
Not applicable
ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.
Not applicable.
ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP
Not applicable.
(2) includes 93,974 shares of Common Stock issuable upon exercise of options
exercisable within 60 days. Also includes 6,045 shares issuable upon
exercise of stock options held by Rosanne Crooke, Dr. Crooke's wife,
exercisable on or before 3/1/97, as to which Dr. Crooke disclaims
beneficial ownership.
Page 3 of 4 pages
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ITEM 9. NOTICE OF DISSOLUTION OF GROUP
Not applicable.
ITEM 10. CERTIFICATION
Not applicable
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.
January 30, 1997
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Date
/s/ Stanley T. Crooke
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Signature
Stanley T. Crooke, Chairman and CEO
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Name/Title
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