MEDAREX INC
S-8, 1999-08-30
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>

     As filed with the Securities and Exchange Commission on August 30, 1999
                           Registration No. 333-_____

                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549


                                   FORM S-8
                            REGISTRATION STATEMENT
                                     UNDER
                          THE SECURITIES ACT OF 1933


                                 MEDAREX, INC.
            (Exact name of registrant as specified in its charter)


              New Jersey                              22-2822175
    (State or other jurisdiction of         (I.R.S. Employer Identification No.)
    incorporation or organization)

    1545 Route 22 East                                      08801
    Annandale, New Jersey                                 (Zip Code)
    (Address of Principal Executive Offices)

                     MEDAREX, INC. 1997 STOCK OPTION PLAN
                           (Full title of the plan)

                              Donald L. Drakeman
                                 Medarex, Inc.
                              1545 Route 22 East
                          Annandale, New Jersey 08801
                    (Name and address of agent for service)

                                (908) 713-6001
         (Telephone number, including area code, of agent for service)

                                   Copy to:
                            Dwight A. Kinsey, Esq.
                     Satterlee Stephens Burke & Burke LLP
                                230 Park Avenue
                           New York, New York 10169
                                (212) 818-9200

                        CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
====================================================================================================================
 Title of Securities to be      Amount to be      Proposed maximum        Proposed maximum          Amount of
         registered            registered (1)    offering price per      aggregate offering      registration fee
                                                      share (2)              price (2)
- --------------------------------------------------------------------------------------------------------------------
<S>                            <C>              <C>                     <C>                       <C>
Common Stock, $.01 par
value per share                750,000 shares          $5.4375              $ 4,078,125              $ 1,200
====================================================================================================================
</TABLE>
 (1)  The registration statement also includes an indeterminable number of
      additional shares that may become issuable as a result of the
      anti-dilution adjustment provisions of the Plan.

 (2)  Estimated solely for the purpose of determining the registration fee
      pursuant to Rule 457(c) and (h) and based upon the average of the high and
      low sale prices of the Company's Common Stock on August 26, 1999, as
      reported by the Nasdaq National Market ("NASDAQ-NMS").
<PAGE>

                                    PART II

Item 3.   Incorporation of Documents by Reference.
- ------    ---------------------------------------
         The following documents filed with the Securities and Exchange
Commission are hereby incorporated by reference:

         (a) Annual Report on Form 10-K for the fiscal year ended December 31,
1998; (b) Quarterly Reports of the Company on Form 10-Q for the three month
periods ended March 31, 1999 and June 30, 1999 (c) Proxy Statement dated April
16, 1999 for Annual Meeting of Shareholders held on May 20, 1999; and (d) the
description of the Registrant's Common Stock set forth in the Registrant's
Registration Statement on Form S-1 (File No. 33-98244), including any amendments
or reports filed for the purpose of updating such description; and

         All reports and other documents filed by the Registrant pursuant to
Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as
amended (the "Exchange Act"), after the filing hereof and prior to a filing of a
post-effective amendment which indicates that all securities offered hereby have
been sold or which deregisters all securities remaining unsold, shall be deemed
to be incorporated by reference herein and to be a part hereof from the date of
the filing of such reports and documents. Any statement contained herein or in
any document incorporated or deemed to be incorporated by reference herein shall
be deemed to be modified or superseded for purposes of this Registration
Statement to the extent that a statement contained herein or in any other
subsequent filed document which also is or is deemed to be incorporated by
reference herein modified or superseded such statement. Any such statement so
modified or superseded shall not be deemed to constitute a part of this
Registration Statement, except as so modified or superseded.


Item 4.   Description of Securities.
- ------    -------------------------
         Not applicable.

Item 5.   Interests of Named Experts and Counsel.
- ------    --------------------------------------

         Dwight A. Kinsey, Esq., a partner of Satterlee Stephens Burke & Burke
LLP, owns 3,000 shares Medarex Common Stock. Mr. Kinsey also holds options to
purchase 42,000 shares of Medarex Common Stock which he received for services
rendered as an officer of Medarex. No other partner or associate of the firm
owns shares or holds options to purchase shares of Medarex.

Item 6.   Indemnification of Directors and Officers.
- ------    -----------------------------------------

         Section 14A:3-5 of The New Jersey Business Corporation Act (the
"NJBCA") empowers a New Jersey corporation to indemnify any person who is or was
a director, officer, employee or agent of the indemnifying corporation or of any
constituent corporation absorbed by the indemnifying corporation in a
consolidation or merger and any person who is or was a director, officer,
trustee, employee or agent of any other enterprise, serving as such at the
request of the indemnifying corporation, or of any such constituent corporation,
or legal representative of any such director, officer, trustee, employee or
agent (a "corporate agent"), against his expenses and liabilities incurred in
connection with any proceeding involving the corporate agent, other than a
proceeding by or in the right of the corporation, if (a) such corporate agent
acted in good faith and in a manner he reasonably believed to be in or not
opposed to the best interests of the corporation and (b) with respect to any
criminal proceeding, such corporate agent had

                                     II-1
<PAGE>

no reason to believe that his conduct was unlawful. In addition, a corporation
may indemnify such corporate agent against his expenses in connection with any
proceeding by or in the right of the corporation to procure a judgment in its
favor which involves such corporate agent by reason of his having been such
corporate agent, if he acted in good faith and in a manner he reasonably
believed to be in or not opposed to the best interests of the corporation.
However, in such proceeding no indemnification shall be provided in respect of
any claim, issue or matter as to which such corporate agent shall have been
adjudged to be liable to the corporation, unless and only to the extent that the
Superior Court of the State of New Jersey or the court in which such proceeding
was brought shall determine upon application that despite the adjudication of
liability, but in view of all circumstances of the case, such corporate agent is
fairly and reasonably entitled to indemnity for such expenses as the Superior
Court or such other court shall deem proper.

         Under the NJBCA, a corporation shall indemnify a corporate agent
against expenses to the extent that such corporate agent has been successful on
the merits or otherwise in any proceeding referred to above or in defense of any
claim, issue or matter therein.

         The indemnification and advancement of expenses provided by or granted
pursuant to the NJBCA shall not exclude any other rights, including the right to
be indemnified against liabilities and expenses incurred in proceedings by or in
the right of the corporation, to which a corporate agent may be entitled under a
certificate of incorporation, bylaw, agreement, vote of shareholders, or
otherwise; provided that no indemnification shall be made to or on behalf of a
corporate agent if a judgment or other final adjudication adverse to the
corporate agent establishes that his acts or omissions (a) were in breach of his
duty of loyalty to the corporation or its shareholders, (b) were not in good
faith or involved a knowing violation of law or (c) resulted in receipt by the
corporate agent of an improper personal benefit.

         The Restated Certificate of Incorporation, as amended, and Article XIII
of the Registrant's Amended and Restated By-Laws provide for the indemnification
of its Officers and Directors under certain circumstances and are incorporated
herein by reference.

Item  7.   Exemption from Registration Claimed.
- -------    -----------------------------------
         Not applicable.

Item  8.   Exhibits.
- -------    --------

                                                                  Sequential
  Exhibit No.                       Description                   Page No.
  ----------                        -----------                   ----------


  4(a)             Restated Certificate of Incorporation, as
                   amended, of Medarex, Inc. (Incorporated by
                   reference to Exhibit 3.1 to the Registrant's
                   Registration Statement on Form S-1 (File No.
                   33-98244) filed on October 17, 1995).

  4(b)             Medarex, Inc. Amended and Restated By-Laws
                   (Incorporated by reference to Exhibit 3.2 to
                   the Registrant's Registration Statement on
                   Form S-1

                                     II-2
<PAGE>

                   (File No. 33-39956) filed on April
                   12, 1991).

5                  Opinion of Satterlee Stephens Burke & Burke           9
                   LLP as to legality of the securities being
                   registered

10.84              Medarex, Inc. 1997 Stock Option Plan (Incorporated by
                   reference to the identically numbered exhibit to the
                   Registrant's Form 10-Q for the three month period ended June
                   30, 1999)

15                 Not Applicable

23(a)              Consent of Ernst & Young LLP                         11

23(b)              Consent of Satterlee Stephens Burke & Burke
                   LLP (included in opinion filed as Exhibit 5)

24                 Power of Attorney (accompanies signature
                   pages to the Registration Statement)

27                 Not Applicable

28                 Not Applicable

99                 Not Applicable

Item 9.   Undertakings.
- ------    ------------

     The undersigned Registrant hereby undertakes as follows:

     (1) To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement:

            (i)   To include any prospectus required by Section 10(a)(3) of the
                  Securities Act of 1933 (the "Securities Act");

            (ii)  To reflect in the prospectus any facts or events arising after
                  the effective date of the registration statement (or the most
                  recent post-effective amendment thereof) which, individually
                  or in aggregate, represent a fundamental change in the
                  information set forth in this registration statement;

            (iii) To include any material information with respect to the plan
                  of distribution not previously disclosed in this registration
                  statement or any material change to such information in this
                  registration statement;

provided, however, that the undertakings set forth in paragraphs (i) and (ii)
above shall not apply if the information required to be included in a post-
effective amendment by those paragraphs is contained in periodic reports filed
with or furnished to the Securities and Exchange Commission by the Registrant
pursuant to Section 13 or Section 15(d) of the Exchange Act that are
incorporated by reference in this registration statement.

                                     II-3
<PAGE>

     (2) That, for the purpose of determining any liability under the Securities
Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such
securities at the time shall be deemed to be the initial bona fide offering
thereof.

     (3) To remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of the
offering.

     (4) That, for purposes of determining any liability under the Securities
Act, each filing of the Registrant's annual report pursuant to Section 13(a) or
Section 15(d) of the Exchange Act (and, where applicable, each filing of an
employee benefit plan's annual report pursuant to Section 15(d) of the Exchange
Act) that is incorporated by reference in this registration statement shall be
deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.

     (5) To deliver or cause to be delivered with the prospectus, to each person
to whom the prospectus is sent or given, the latest annual report to security
holders that is incorporated by reference in the prospectus and furnished
pursuant to and meeting the requirements of Rule 14a-3 or Rule 14c-3 under the
Exchange Act; and, where interim financial information required to be presented
by Article 3 of Regulation S-X is not set forth in the prospectus, to deliver,
or cause to be delivered to each person to whom the prospectus or cause to be
delivered to each person to whom the prospectus is sent or given, the latest
quarterly report that is specifically incorporated by reference in the
prospectus to provide such interim financial information.

     (6) Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers, and controlling persons of the
Registrant pursuant to the foregoing provisions or otherwise, the Registrant has
been advised that in the opinion of the Securities and Exchange Commission such
indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses
incurred or paid by a director, officer or controlling person of the Registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Securities Act and will be governed by the final
adjudication of such issue.

                                     II-4
<PAGE>

                                  SIGNATURES

          Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this registration
statement or amendment thereto to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Annandale, State of New Jersey, on
this 26th day of August, 1999.

                                 MEDAREX, INC.


                                 By:/s/Irwin Lerner
                                    ---------------------
                                    Irwin Lerner
                                    Chairman of the Board

                                 POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS:

          That the undersigned officers and directors of Medarex, Inc., a New
Jersey corporation, do hereby constitute and appoint Donald L. Drakeman and
Michael A. Appelbaum, and either of them, the lawful attorney and agent, with
power and authority to do any and all acts and things and to execute any and all
instruments which said attorney and agent, determine may be necessary or
advisable or required to enable said corporation to comply with the Securities
Act of 1933, as amended, and any rules or regulations or requirements of the
Securities and Exchange Commission in connection with this Registration
Statement. Without limiting the generality of the foregoing power of authority,
the powers granted include the power and authority to sign the names of the
undersigned officers and directors in the capacities indicated below to this
Registration Statement, to any and all amendments and supplements thereof, and
to any and all instruments or documents filed as part of or in connection with
such Registration Statement, and each of the undersigned hereby certifies and
confirms all that said attorney and agent, shall do or cause to be done by
virtue hereof. The Power of Attorney may be signed in several counterparts.

          IN WITNESS WHEREOF, the undersigned has executed this Power of
Attorney as of the dates indicated below.

          Pursuant to the requirements of the Securities Act of 1933, as
amended, this Registration Statement has been signed below by the following
persons in the capacities and on the dates indicated.

<TABLE>
<CAPTION>

                 Signature                            Title                                      Date
                 ---------                            -----                                      ----
<S>                                          <C>                                           <C>
/s/Irwin Lerner                              Chairman of the Board                            August 26, 1999
- -----------------------------------
Irwin Lerner

/s/Donald L. Drakeman                        President, Chief Executive Officer and           August 26, 1999
- -----------------------------------          Director (Principal Executive Officer)
Donald L. Drakeman

/s/Michael A. Appelbaum                      Executive Vice President - Finance and           August 26, 1999
- -----------------------------------          Administration, Secretary, Treasurer, Chief
Michael A. Appelbaum                         Financial Officer and Director (Principal
                                             Financial and Accounting Officer)


/s/Michael W. Fanger                         Director                                         August 26, 1999
- -----------------------------------
Michael W. Fanger

/s/Julius A. Vida                            Director                                         August 26, 1999
- -----------------------------------
Julius A. Vida

                                             Director
- -----------------------------------
Charles R. Schaller

/s/W. Leigh Thompson, Jr.                    Director                                         August 26, 1999
- -----------------------------------
W. Leigh Thompson, Jr.

                                             Director
- -----------------------------------
Robert Iggulden

                                             Director
- -----------------------------------
Frederick B. Craves
</TABLE>
<PAGE>

                               INDEX TO EXHIBITS



                                                                  Sequential
  Exhibit No.                       Description                   Page No.
  ----------                        -----------                   ----------


4(a)               Restated Certificate of Incorporation, as
                   amended, of Medarex, Inc. (Incorporated by
                   reference to Exhibit 3.1 to the Registrant's
                   Registration Statement on Form S-1 (File No.
                   33-98244) filed on October 17, 1995).


4(b)               Medarex, Inc. Amended and Restated By-Laws
                   (Incorporated by reference to Exhibit 3.2 to
                   the Registrant's Registration Statement on
                   Form S-1 (File No. 33-39956) filed on April
                   12, 1991).


5                  Opinion of Satterlee Stephens Burke & Burke           9
                   LLP as to legality of the securities being
                   registered

10.84              Medarex, Inc. 1997 Stock Option Plan (Incorporated by
                   reference to the identically numbered exhibit to the
                   Registrant's Form 10-Q for the three month period ended June
                   30, 1999)

23(a)              Consent of Ernst & Young LLP                         10

23(b)              Consent of Satterlee Stephens Burke & Burke LLP
                   (included in opinion filed as Exhibit 5)

24                 Power of Attorney (accompanies signature
                   pages to the Registration Statement)

<PAGE>

                                 Exhibit No. 5


       Opinion of Satterlee Stephens Burke & Burke LLP as to Legality of
                        the Securities being Registered
<PAGE>

                     SATTERLEE STEPHENS BURKE & BURKE LLP
                                230 Park Avenue
                           New York, N.Y. 10169-0079
                                (212) 818-9200




                                                    August 30, 1999


Medarex, Inc.
1545 Route 22 East
Annandale, New Jersey  08801

Dear Sirs:

                  You have asked for our opinion in connection with a
Registration Statement on Form S-8 to be filed with the Securities and Exchange
Commission for registration pursuant to the Securities Act of 1933, as amended
of 750,000 shares of common stock, par value $.01 per share, of Medarex, Inc.
(the "Company") reserved for issuance pursuant to the Company's 1997 Stock
Option Plan (the "Plan").

                  As counsel for the Company, we are familiar with the Plan, as
amended to date, and with the corporate proceedings relating thereto and to the
Registration Statement hereinabove referred to. Based on the foregoing, it is
our opinion that the shares reserved under the Plan, upon issuance on exercise
in accordance with the provisions of the stock option agreements evidencing
options granted thereunder, will be validly issued, fully paid and non-
assessable with no personal liability attaching to the ownership thereof under
the laws of the State of New Jersey.

                  We understand that a copy of this opinion will be filed as an
exhibit to the Registration Statement and we hereby consent to such filing.




                                   SATTERLEE STEPHENS BURKE & BURKE LLP

<PAGE>

                               Exhibit No. 23(a)


                         Consent of Ernst & Young LLP
<PAGE>

                        Consent of Independent Auditors
                        -------------------------------


We consent to the incorporation by reference in the Registration Statement (Form
S-8 No. 333-00000) pertaining to the Medarex, Inc. 1997 Stock Option Plan of our
report dated February 10, 1999, except for Note 14 as to which the date is
February 25, 1999, with respect to the consolidated financial statements of
Medarex, Inc. included in its Annual Report (Form 10-K) for the year ended
December 31, 1998, filed with the Securities and Exchange Commission.



                                          /s/ ERNST & YOUNG LLP


Princeton, New Jersey
August 24, 1999


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