MEDAREX INC
4, 2000-10-04
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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+--------+
| FORM 4 |                       U.S. SECURITIES AND EXCHANGE COMMISSION
+--------+                               WASHINGTON, D.C. 20549
[_] Check this box if
    no longer subject         STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP
    to Section 16.
    Form 4 or Form 5       Filed pursuant to Section 16(a) of the Securities
    obligations may           Exchange Act of 1934, Section 17(a) of the
    continue. See            Public Utility Holding Company Act of 1935 or
    Instruction 1(b).      Section 30(f) of the Investment Company Act of 1940

--------------------------------------------------------------------------------
1.  Name and Address of Reporting Person

Craves                             Fred                          B.
c/o Bay City Capital LLC
--------------------------------------------------------------------------------
        (Last)                      (First)                        (Middle)

750 Battery Street, Suite 600
--------------------------------------------------------------------------------
                                   (Street)

San Francisco                       CA                               94111
--------------------------------------------------------------------------------
        (City)                      (State)                           (Zip)


2.  Issuer Name and Ticker or Trading Symbol       Medarex, Inc. (MEDX)
                                             -----------------------------------

3.  IRS or Social Security Number of Reporting Person (Voluntary)   000-00-0000
                                                                  --------------

4.  Statement for Month/Year                  September 2000
                             ---------------------------------------------------

5.  If Amendment, Date of Original (Month/Year)
                                               ---------------------------------


6.  Relationship of Reporting Person to Issuer (Check all applicable)


    [X] Director    [ ] Officer             [ ] 10% Owner    [ ] Other
                        (give title below)                       (specify below)


7.  Individual or Joint/Group Filing (Check applicable line)

    [X] Form filed by One Reporting Person

    [ ] Form filed by More than One Reporting Person

    ----------------------------------------------------------------------------


TABLE I--NON-DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED

<TABLE>
<CAPTION>
------------------------------------------------------------------------------------------------------------------------------------
1. Title              2. Trans-  3. Trans-       4. Securities Acquired (A)        5. Amount of         6. Owner-     7. Nature
   of                    action     action          or Disposed of (D)                Securities           ship          of In-
   Security              Date       Code            (Instr. 3, 4 and 5)               Beneficially         Form:         direct
   (Instr. 3)            (Month/    (Instr. 8)                                        Owned at             Direct        Bene-
                         Day/    -----------------------------------------------      End of               (D) or        ficial
                         Year)                                                        Month                Indirect      Owner-
                                  Code       V   Amount        (A) or    Price        (Instr. 3 and 4)     (I)           ship
                                                               (D)                                         (Instr. 4)    (Instr. 4)
------------------------------------------------------------------------------------------------------------------------------------
<S>                   <C>        <C>         <C> <C>           <C>       <C>       <C>                  <C>           <C>
Common Stock          9/12/2000    S              1,031        (D)       107.9911                            I        * (See below)
------------------------------------------------------------------------------------------------------------------------------------
Common Stock          9/13/2000    S              3,025        (D)       106.5168                            I
------------------------------------------------------------------------------------------------------------------------------------
Common Stock          9/14/2000    S              7,378        (D)       110.0375                            I
------------------------------------------------------------------------------------------------------------------------------------
Common Stock          9/15/2000    S                826        (D)       110.8839                            I
------------------------------------------------------------------------------------------------------------------------------------
Common Stock          9/18/2000    S                221        (D)       106.3333                            I
------------------------------------------------------------------------------------------------------------------------------------
Common Stock          9/22/2000    S              2,361        (D)       103.2969                            I
------------------------------------------------------------------------------------------------------------------------------------
Common Stock          9/25/2000    S              1,033        (D)       109.8304                            I
------------------------------------------------------------------------------------------------------------------------------------
Common Stock          9/26/2000    S                590        (D)       108.8438                            I
------------------------------------------------------------------------------------------------------------------------------------
Common Stock          9/27/2000    S              2,361        (D)       114.1211                            I
------------------------------------------------------------------------------------------------------------------------------------
Common Stock          9/28/2000    S              1,328        (D)       115.8333                            I
------------------------------------------------------------------------------------------------------------------------------------
Common Stock          9/29/2000    S                590        (D)       118.4375                            I
------------------------------------------------------------------------------------------------------------------------------------
Common Stock         10/02/2000    S                590        (D)       118                                 I
------------------------------------------------------------------------------------------------------------------------------------
Common Stock         10/03/2000    S                797        (D)       109.9269          77,598            I
------------------------------------------------------------------------------------------------------------------------------------
* In a series of open market transactions, BCC Acquisition I LLC ("BCC
Acquisition") sold 750,000 shares of Issuer's Common Stock. See explanation 1,
below for the nature of the Reporting Person's indirect ownership.
-------------
</TABLE>
Reminder: Report on a separate line for each class of securities beneficially
owned directly or indirectly. (Print or Type Responses)

<PAGE>

FORM 4 (continued)

  TABLE II--DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
        (e.g., puts, calls, warrants, options, convertible securities)

<TABLE>
<CAPTION>
-----------------------------------------------------------------------------------------------------------------------------
 1. Title of Derivative            2. Conver-          3. Trans-           4. Transac-            5. Number of Deriv-
    Security (Instr. 3)               sion or             action              tion Code              ative Securities
                                      Exercise            Date                (Instr. 8)             Acquired (A) or
                                      Price of            (Month/                                    Disposed of (D)
                                      Deriv-              Day/                                       (Instr. 3, 4, and 5)
                                      ative               Year)
                                      Security

                                                                           ---------------------------------------------------
                                                                           Code      V                 (A)         (D)

-----------------------------------------------------------------------------------------------------------------------------
<S>                                <C>                 <C>                 <C>       <C>          <C>              <C>

</TABLE>

 TABLE II--DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
   (e.g., puts, calls, warrants, options, convertible securities)--CONTINUED
<TABLE>
<CAPTION>
------------------------------------------------------------------------------------------------------------------------------------
 1. Title of Derivative       6. Date Exer-     7. Title and Amount of       8. Price    9. Number       10. Owner-    11. Na-
    Security (Instr. 3)          cisable and       Underlying Securities        of          of Deriv-        ship          ture
                                 Expiration        (Instr. 3 and 4)             Deriv-      ative            Form          of In-
                                 Date                                           ative       Secur-           of De-        direct
                                 (Month/Day/                                    Secur-      ities            rivative      Bene-
                                 Year)                                          ity         Bene-            Secu-         ficial
                                                                                (Instr.     ficially         rity:         Owner-
                               --------------------------------------------     5)          Owned            Direct        ship
                               Date     Expira-              Amount or                      at End           (D) or        (Instr.
                               Exer-    tion         Title   Number of                      of               Indi-         4)
                               cisable  Date                 Shares                         Month            rect (1)
                                                                                            (Instr. 4)       (Instr. 4)
------------------------------------------------------------------------------------------------------------------------------------
<S>                           <C>       <C>     <C>          <C>             <C>         <C>             <C>           <C>

</TABLE>

Explanation of Responses:

1. Fred B. Craves' indirect ownership of the Issuer's Common Stock is derived as
   follows: The Bay City Capital Fund I, L.P. ("BCC") has approximately a
   74.634% proportional interest in the capital account of BCC Acquisition. Bay
   City Capital Management LLC ("BCC Management") owns a 3.75% general
   partnership interest in BCC. The Graves Group LLC owns a 50% proportional
   interest in the capital account of BCC Management. Fred B. Craves owns a 1/3
   proportional interest in the capital account of The Craves Group LLC. In
   addition, The Craves Group LLC has a 10% limited partnership interest in BCC.
   The Reporting Person disclaims beneficial ownership of the Shares except to
   the extent of his pecuniary interest therein.

**Intentional misstatements or omissions of facts constitute Federal Criminal
  Violations.
  See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note:  File three copies of this Form, one of which must be manually signed.
       If space provided is insufficient, see Instruction 6 for procedure.

                                  /s/ Fred B. Craves            10/04/00
                              -------------------------------  -----------------
                              **Signature of Reporting Person        Date





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