CAMBRIDGE NEUROSCIENCE INC
SC 13D/A, 2000-12-08
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                    Under the Securities Exchange Act of 1934

                               (Amendment No. 1)*

Cambridge NeuroScience, Inc.
(Name of Issuer)

Common Stock
(Title of Class of Securities)

132426107
(CUSIP Number)

Robert L. Chapman, Jr., Chapman Capital L.L.C.
Continental Grand Plaza #411, 300 N. Continental Blvd.
El Segundo, California 90245
Tel: (310) 563-6900
(Name, Address and Telephone Number of Person Authorized to Receive Notices and
 Communications)

December 7, 2000
(Date of Event Which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box
[ ].

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule,  including  all  exhibits.  See Rule 13d-7(b) for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                          (Continued on the following pages)
                                  (Page 1 of 8)



<PAGE>


Page 8 of 8


EWAGNE\36061.1 - 12/7/00
1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                  Chap-Cap Partners, L.P., a Delaware Limited Partnership

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
         (a)[x]
         (b)[ ]

3.       SEC USE ONLY

4.       SOURCE OF FUNDS*
                  WC

5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
        ITEMS 2(d) or 2(e) [  ]

6.       CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

7.       SOLE VOTING POWER
                  0

8        SHARED VOTING POWER
                  1,532,500

9.       SOLE DISPOSITIVE POWER
                  0

10.      SHARED DISPOSITIVE POWER
                  1,532,500

11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  1,532,500

12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
         EXCLUDES CERTAIN SHARES*   [ ]

13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  8.4%

14.      TYPE OF REPORTING PERSON*
                  PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                  Chapman Capital L.L.C., a Delaware Limited Liability Company

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
         (a)[x]
         (b)[ ]

3.       SEC USE ONLY

4.       SOURCE OF FUNDS*
                  WC

5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
        ITEMS 2(d) or 2(e) [  ]

6.       CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

7.       SOLE VOTING POWER
                  0

8        SHARED VOTING POWER
                  1,532,500

9.       SOLE DISPOSITIVE POWER
                  0

10.      SHARED DISPOSITIVE POWER
                  1,532,500

11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  1,532,500

12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
         EXCLUDES CERTAIN SHARES*   [ ]

13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  8.4%

14.      TYPE OF REPORTING PERSON*
                  OO

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                  Robert L. Chapman, Jr.

2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
         (a)[x]
         (b)[ ]

3.       SEC USE ONLY

4.       SOURCE OF FUNDS*
                  WC

5.       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
        ITEMS 2(d) or 2(e) [  ]

6.       CITIZENSHIP OR PLACE OF ORGANIZATION
                  United States

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

7.       SOLE VOTING POWER
                  0

8        SHARED VOTING POWER
                  1,532,500

9.       SOLE DISPOSITIVE POWER
                  0

10.      SHARED DISPOSITIVE POWER
                  1,532,500

11.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  1,532,500

12.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
         EXCLUDES CERTAIN SHARES*   [ ]

13.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                  8.4%

14.      TYPE OF REPORTING PERSON*
                  IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


         This  statement is filed  pursuant to Rule 13d-2(a) with respect to the
shares of common stock of Cambridge NeuroScience, Inc. beneficially owned by the
Reporting  Persons  specified  herein  as of  December  7, 2000 and  amends  and
supplements  the  Schedule 13D dated June 5, 2000.  Except as set forth  herein,
such Schedule 13D is unmodified.

ITEM 1.  Security and Issuer.

         This  statement  relates to the common  stock (the  "Common  Stock") of
Cambridge  Neuroscience,  Inc. (the "Issuer").  The Issuer's principal executive
office is located at 333 Providence Highway, Norwood, MA 02062.

ITEM 2.  Identity and Background.

         (a)-(c)  This statement is being filed by Chap-Cap Partners, L.P., a
Delaware limited partnership ("Chap-Cap"), Chapman Capital L.L.C., a Delaware
limited liability company ("Chapman Capital"), and Robert L. Chapman, Jr.
(collectively, the "Reporting Persons").  Chap-Cap's present principal business
is investing in marketable securities.  Chapman Capital's present principal
business is serving as the General Partner of Chap-Cap.  Robert L. Chapman,
Jr.'s present principal occupation is serving as Managing Member of Chapman
Capital.  Chapman Capital and Robert L. Chapman, Jr. each expressly disclaims
equitable ownership of and pecuniary
interest in any Common Stock.

         Chap-Cap, Chapman Capital and Robert Chapman, Jr.'s business address
is Continental Grand Plaza, Fourth Floor, 300 North Continental Blvd., El
Segundo, California 90245.

         (d) and (e) During the last five years, none of the persons or entities
above  has  been (i)  convicted  in a  criminal  proceeding  (excluding  traffic
violations or similar misdemeanors);  or (ii) a party to a civil proceeding of a
judicial or  administrative  body of competent  jurisdiction  and as a result of
such proceeding was or is subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to, federal
or state securities laws or finding any violation with respect to such laws.

         (f)      Robert Chapman, Jr. is a citizen of the United States.

ITEM 3.  Source and Amount of Funds or Other Consideration.

The source and amount of funds  used by the  Reporting  Persons in making  their
purchases of the shares of Common Stock beneficially owned by them are set forth
below:

SOURCE OF FUNDS                                      AMOUNT OF FUNDS
Working Capital                                      $1,858,488

ITEM 4.  Purpose of Transaction.

         The Reporting Persons acquired the Common Stock  beneficially  owned by
them in the ordinary  course of their trade or business of purchasing,  selling,
trading and investing in securities.

         The Reporting  Persons intend to review their  investment in the Issuer
on a continuing basis and, depending on various factors,  including the Issuer's
business,  affairs and financial  position,  other  developments  concerning the
Issuer,  the price  level of the  Common  Stock,  conditions  in the  securities
markets  and  general  economic  and  industry  conditions,  as  well  as  other
investment  opportunities available to them, may in the future take such actions
with respect to their investment in the Issuer as they deem appropriate in light
of the  circumstances  existing  from time to time.  Such  actions may  include,
without  limitation,  the purchase of  additional  shares of Common Stock in the
open  market  and in block  trades,  in  privately  negotiated  transactions  or
otherwise,  the sale at any time of all or a  portion  of the  Common  Stock now
owned  or  hereafter  acquired  by  them  to  one  or  more  purchasers,  or the
distribution  in kind at any time of all or a portion  of the  Common  Stock now
owned or hereafter acquired by them.

         Robert L. Chapman Jr. has met with  management of the Issuer  regarding
the  possibility  of, or seeking to influence the  management of the Issuer with
respect to, board  representation,  business strategies,  legal strategies,  tax
strategies, mergers, business combinations,  recapitalizations, sales of assets,
negotiated or open-market  stock  repurchases or other  extraordinary  corporate
transactions.  Specifically, on July 12, 2000 Mr. Chapman met with Dr. Robert N.
McBurney,  the Chief Executive Officer and the President of the Issuer,  and Dr.
Daniel  Roach,  Chief  Executive  Officer  of  the  Issuer's   acquirer,   CeNeS
Pharmaceuticals Plc, to discuss the anticipated  pro-forma capital structure and
business  model of the  merged  companies.  During  this  meeting,  Mr.  Chapman
articulated the importance of CeNeS maintaining moderate, controlled growth with
particular  care to  eschew  dilutive  share  issuances  sometimes  utilized  by
poorly-managed  biopharmaceutical  peers.  In addition,  Mr.  Chapman  advocated
CeNeS's  openness to being  acquired  by one of the many  larger  pharmaceutical
companies  potentially  interested in the company's  Moraxen product (for severe
pain) and  burgeoning  new product  pipeline  dealing  with the central  nervous
system.

         The Reporting Persons may in the future consider a variety of different
alternatives to achieving their goal of maximizing  shareholder value, including
negotiated transactions,  tender offers, proxy contests,  consent solicitations,
or other actions.  However,  it should not be assumed that the Reporting Persons
will take any of the foregoing actions.  The Reporting Persons reserve the right
to participate,  alone or with others, in plans,  proposals or transactions of a
similar or different nature with respect to the Issuer.

         Except as set forth  above,  as of the date of this  filing none of the
Reporting Persons has any plans or proposals, which relate to or would result in
any of the actions  set forth in parts (a)  through (j) of Item 4. Such  persons
may at any time  reconsider and change their plans or proposals  relating to the
foregoing.


<PAGE>


ITEM 5.  Interest in Securities of the Issuer.

         (a)  Together,  the  Reporting  Persons  beneficially  own a  total  of
1,532,500  shares of Common Stock  constituting  8.4% of all of the  outstanding
shares of Common Stock.

         (b) The  Reporting  Persons have the shared power to vote or direct the
vote of, and to dispose or direct the disposition of, the shares of Common Stock
beneficially owned by them.

         (c)      The following transactions were effected by the Reporting
Persons during the past sixty (60) days:

                                                              Approximate Price
                                    per Share
                                    Amount of                 (exclusive of
Date              Security Shares Bought    commissions)
----              -------- -------------    ------------
12/07/00 Common   580,000           $1.28

         The above  transaction was effected by the Reporting Persons on the OTC
Bulletin Board.

         Other than the transactions described above, no other transactions with
respect to the Common Stock were  effected by the Reporting  Persons  during the
past sixty (60) days.

         (d) No person other than the Reporting Persons has the right to receive
or the power to direct the receipt of dividends  from,  or the proceeds from the
sale of, the shares of Common Stock beneficially owned by the Reporting Persons.

         (e)      Not applicable.

ITEM 6.           Contracts, Arrangements, Understandings or Relationships With
                Respect to Securities of the Issuer.

         Not applicable.

ITEM 7.  Material to be Filed as Exhibits.

         Exhibit A - Joint Filing Agreement (previously filed)



<PAGE>


                                   SIGNATURES

         After  reasonable  inquiry and to the best of its knowledge and belief,
the undersigned each certifies that the information with respect to it set forth
in this statement is true, complete and correct.

Dated:  December 7, 2000


CHAP-CAP PARTNERS, L.P.

By: Chapman Capital L.L.C.,
         as General Partner


By: /s/ Robert L. Chapman, Jr.
    --------------------------
         Robert L. Chapman, Jr.
         Managing Member


CHAPMAN CAPITAL L.L.C.


By: /s/ Robert L. Chapman, Jr.
    --------------------------
         Robert L. Chapman, Jr.
         Managing Member



 /s/ Robert L. Chapman, Jr.
---------------------------
         Robert L. Chapman, Jr.



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