ALKERMES INC
424B3, 1998-09-25
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1

Prospectus Supplement No. 8                       Filed Pursuant To Rule 424B(3)
to Prospectus dated April 27, 1998                File No.            333-50157

                                 ALKERMES, INC.

       2,300,000 SHARES OF $3.25 CONVERTIBLE EXCHANGEABLE PREFERRED STOCK

             $115,000,000 6 1/2% CONVERTIBLE SUBORDINATED DEBENTURES

                        3,881,940 SHARES OF COMMON STOCK

     This Prospectus Supplement supplements information contained in that
certain Prospectus of Alkermes, Inc. (the "Company") dated April 27, 1998 (the
"Prospectus") relating to the potential resale from time to time of $3.25
Convertible Exchangeable Preferred Stock, par value $.01 per share (the
"Preferred Stock"), 6 1/2% Convertible Subordinated Debentures (if issued) (the
"Debentures") and Common Stock (the "Common Stock") issuable upon conversion of
the Preferred Stock or Debentures (if issued). This Prospectus Supplement is not
complete without, and may not be delivered or utilized except in connection
with, the Prospectus, including any amendments or supplements thereto.
Capitalized terms used herein but not defined have the meanings assigned to such
terms in the Prospectus.

     The following table supplements the information set forth in the Prospectus
under the caption "Selling Shareholders" with respect to the Selling
Shareholders and the respective amount of shares of Preferred Stock beneficially
owned by each Selling Shareholder and that may be sold, the principal amount of
Debentures which would be beneficially owned and may be sold by each Selling
Shareholder, and number of shares of Common Stock that may be sold by the
Selling Shareholders pursuant to this Prospectus, as amended or supplemented:
<TABLE>
<CAPTION>

                                 NUMBER OF
                                 SHARES OF                   PRINCIPAL
                                 PREFERRED                   AMOUNT OF
                                   STOCK                     DEBENTURES    NUMBER OF
                               BENEFICIALLY     PERCENT OF  BENEFICIALLY  CONVERSION
                                 OWNED AND     OUTSTANDING   OWNED AND     SHARES
                                 THAT MAY       PREFERRED     THAT MAY     THAT MAY
NAME (1)                          BE SOLD        STOCK        BE SOLD     BE SOLD (2)
- --------                       ------------  -------------  ------------  -----------
<S>                               <C>                       <C>              <C>   
Donaldson, Lufkin & Jenrette      15,000           *        $  750,000       25,317
Securities Corporation

BancBoston, Robertson Stephens    25,000          1.09%     $1,250,000       42,195
</TABLE>

- ------------------
*    Less than 1%.

(1)  The information set forth herein is as of September 24, 1998 and will be
     updated as required.

(2)  Assumes conversion of the full amount of Preferred Stock held by such
     holder at the initial conversion rate of 1.6878 shares of Common Stock for
     each share of Preferred Stock.

          THE DATE OF THIS PROSPECTUS SUPPLEMENT IS SEPTEMBER 25, 1998




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