ALKERMES INC
8-K, 1999-02-12
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1
                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549



                                    FORM 8-K

                                 CURRENT REPORT



     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934


        Date of Report (Date of earliest event reported) FEBRUARY 1, 1999



                                 ALKERMES, INC.
             (Exact name of registrant as specified in its charter)



        PENNSYLVANIA                  0-19267                    23-2472830 
  (State of incorporation)     (Commission File Number)        (IRS Employer
                                                             Identification No.)


                                64 SIDNEY STREET
                            CAMBRIDGE, MA 02139-4136
          (Address of principal executive offices, including zip code)


        Registrant's telephone number, including area code (617) 494-0171


<PAGE>   2
ITEM 2.  ACQUISITION OR DISPOSITION OF ASSETS.


             On February 1, 1999, the Registrant acquired Advanced Inhalation
Research, Inc., a Delaware corporation ("AIR"), through the merger of Alkermes
Acquisition Sub, Inc., a wholly owned subsidiary of the Registrant (the "Sub")
with and into AIR (the "Merger"), with AIR surviving the Merger as a wholly
owned subsidiary of the Registrant. Pursuant to the Agreement and Plan of Merger
by and among the Registrant, the Sub and AIR (the "Merger Agreement"), the
Registrant issued approximately 3,680,500 shares of its Common Stock to the
stockholders of AIR in a transaction intended to qualify as a tax-free pooling
of interests. The Registrant has agreed to register all of such shares for
resale under the Securities Act of 1933, as amended. An additional 119,474
shares of Common Stock were reserved for issuance upon the exercise of currently
unvested stock options granted to employees and consultants of AIR which were
assumed by the Registrant.

ITEM 7.  FINANCIAL STATEMENTS AND EXHIBITS.

         (c)      Exhibits

                  2.1      Form of Agreement and Plan of Merger by and among
                           Alkermes, Inc., Alkermes Acquisition Sub, Inc. and
                           Advanced Inhalation Research, Inc.

                  4.1      Form of Agreement with the Company's Stockholders by
                           and among Alkermes, Inc., Advanced Inhalation
                           Research, Inc. and the stockholders of Advanced
                           Inhalation Research, Inc.



                                        2
<PAGE>   3
                                   SIGNATURES


             Pursuant to the requirements of the Securities Exchange Act of
1934, the Registrant has duly caused this report to be signed on its behalf by
the undersigned, hereunto duly authorized.




Dated: February 12, 1999                          ALKERMES, INC.


                                               By: James M. Frates
                                                   ----------------------------
                                                   Name: James M. Frates
                                                   Title: Vice President, Chief
                                                          Financial Officer and
                                                          Treasurer


                                        3
<PAGE>   4
                                  EXHIBIT INDEX


Exhibit No.       Exhibits

         2.1      Form of Agreement and Plan of Merger by and among Alkermes,
                  Inc., Alkermes Acquisition Sub, Inc. and Advanced Inhalation
                  Research, Inc.

         4.1      Form of Agreement with the Company's Stockholders by and among
                  Alkermes, Inc., Advanced Inhalation Research, Inc. and the
                  stockholders of Advanced Inhalation Research, Inc.

<PAGE>   1
                                                                     EXHIBIT 2.1


                          AGREEMENT AND PLAN OF MERGER

                                      AMONG

                                 ALKERMES, INC.

                       ALKERMES ACQUISITION SUB, INC., AND

                       ADVANCED INHALATION RESEARCH, INC.



<PAGE>   2
                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                            PAGE
<S>               <C>                                                       <C>
SECTION 1         THE MERGER.................................................1

         1.1      The Merger.................................................1
         1.2      Effective Time.............................................1
         1.3      Effect of the Merger.......................................2
         1.4      Certificate of Incorporation and Bylaws....................2
         1.5      Directors and Officers.....................................2
         1.6      Conversion of Stock........................................2
         1.7      Closing of Company Transfer Books..........................4
         1.8      Dissenting Shares..........................................4
         1.9      Exchange of Certificates...................................5
         1.10     No Fractional Shares.......................................5

SECTION 2         REPRESENTATIONS AND WARRANTIES OF COMPANY..................6

         2.1      Organization and Qualification.............................6
         2.2      Authority to Execute and Perform Agreements................7
         2.3      Capitalization and Title to Shares.........................7
         2.4      Subsidiaries and Other Affiliates..........................8
         2.5      Financial Statements.......................................8
         2.6      Absence of Undisclosed Liabilities.........................8
         2.7      No Material Adverse Change.................................8
         2.8      Tax Matters................................................9
         2.9      Compliance with Laws......................................10
         2.10     No Breach.................................................11
         2.11     Actions and Proceedings...................................11
         2.12     Contracts and Other Agreements............................11
         2.13     Bank Accounts and Powers of Attorney......................12
         2.14     Properties................................................12
         2.15     Intellectual Property.....................................12
         2.16     Employee Benefit Plans....................................13
         2.17     Employee Relations........................................14
         2.18     Section 83(b) Election....................................14
         2.19     Insurance.................................................14
         2.20     Brokerage.................................................14
         2.21     Hazardous Materials.......................................15
         2.22     Year 2000 Compliance......................................15
         2.23     Disclosure................................................16
         2.24     M.I.T. Agreement Compliance...............................16
</TABLE>


                                        i
<PAGE>   3
                                TABLE OF CONTENTS
                                   (CONTINUED)

<TABLE>
<CAPTION>
                                                                            PAGE


<S>               <C>                                                       <C>
SECTION 3         REPRESENTATIONS AND WARRANTIES OF PARENT AND THE
                  ACQUISITION SUB...........................................16

         3.1      Organization and Qualification............................16
         3.2      Authority to Execute and Perform Agreements...............17
         3.3      Capitalization............................................17
         3.4      Subsidiaries and Other Affiliates.........................18
         3.5      SEC Filings; Parent Financial Statements..................18
         3.6      Tax Matters...............................................19
         3.7      No Material Adverse Change................................20
         3.8      Compliance with Laws......................................20
         3.9      No Breach.................................................20
         3.10     Actions and Proceedings...................................20
         3.11     Contracts and Other Agreements............................21
         3.12     Intellectual Property.....................................21
         3.13     Brokerage.................................................21
         3.14     Environmental Matters.....................................22
         3.15     Millennium Plan...........................................22
         3.16     Disclosure................................................22

SECTION 4         COVENANTS AND AGREEMENTS..................................22

         4.1      Conduct of Business.......................................22
         4.2      Covenants of the Company Pending Closing..................22
         4.3      Corporate Examinations and Investigations.................24
         4.4      Expenses..................................................24
         4.5      Authorization from Others.................................24
         4.6      Consummation of Agreement.................................24
         4.7      Further Assurances........................................24
         4.8      Registration of Parent Shares.............................24
         4.9      Public Announcements and Confidentiality..................25
         4.10     No Solicitation...........................................25
         4.11     Intentionally Omitted.....................................25
         4.12     Parent SEC Filings........................................25
         4.13     Employee Benefits Matters.................................25
         4.14     Conduct of the Surviving Corporation......................26
         4.15     Indemnification of Directors and Officers.................26
         4.16     Notice of Developments....................................27
</TABLE>


                                       ii
<PAGE>   4
                                TABLE OF CONTENTS
                                   (CONTINUED)

<TABLE>
<CAPTION>
                                                                            PAGE


<S>               <C>                                                       <C>
         4.17     Tax-free Reorganization...................................27
         4.18     Pooling-of-Interests......................................27
         4.19     Continuation of Employment and Consulting Arrangements....28

SECTION 5         CONDITIONS PRECEDENT TO THE OBLIGATIONS OF EACH
                  PARTY TO CONSUMMATE THE MERGER............................28

         5.1      Approvals.................................................28
         5.2      Absence of Order..........................................28

SECTION 6         CONDITIONS PRECEDENT TO THE OBLIGATIONS OF PARENT AND
                  THE ACQUISITION SUB TO CONSUMMATE THE MERGER..............28

         6.1      Representations, Warranties and Covenants.................28
         6.2      Stockholder Approval......................................28
         6.3      Intentionally Omitted.....................................28
         6.4      Opinion of Counsel to Company.............................29
         6.5      Merger Documents..........................................29
         6.6      Certificates..............................................29
         6.7      Stockholders' Agreement...................................29
         6.8      Co-Sale Agreement.........................................29
         6.9      Management Rights Letter Agreements.......................29
         6.10     Investors' Rights Agreement...............................29
         6.11     New Agreement.............................................29
         6.12     Tax Opinion...............................................29
         6.13     Patent Opinion............................................29
         6.14     Accounting Treatment......................................29

SECTION 7         CONDITIONS PRECEDENT TO THE OBLIGATION OF THE
                  COMPANY TO CONSUMMATE THE MERGER..........................30

         7.1      Representations, Warranties and Covenants.................30
         7.2      Opinion of Counsel to Parent..............................30
         7.3      Certificates..............................................30
         7.4      Employment and Consulting Agreements......................30
         7.5      Tax Opinion...............................................30
</TABLE>


                                       iii
<PAGE>   5
                                TABLE OF CONTENTS
                                   (CONTINUED)

<TABLE>
<CAPTION>
                                                                           PAGE


<S>               <C>                                                       <C>
SECTION 8         TERMINATION, AMENDMENT AND WAIVER.........................30

         8.1      Termination...............................................30
         8.2      Effect of Termination.....................................31
         8.3      Amendment.................................................31
         8.4      Waiver....................................................31

SECTION 9         INDEMNIFICATION...........................................32

         9.1      Survival..................................................32
         9.2      Indemnification...........................................32

SECTION 10        GLOSSARY OF DEFINED TERMS.................................32

         10.1     Glossary..................................................32

SECTION 11        MISCELLANEOUS.............................................34

         11.1     Notices...................................................34
         11.2     Entire Agreement..........................................35
         11.3     Governing Law.............................................35
         11.4     Binding Effect; No Assignment.............................36
         11.5     Variations in Pronouns....................................36
         11.6     Counterparts..............................................36
         11.7     Disclosure Schedules......................................36
</TABLE>


                                       iv
<PAGE>   6
                          AGREEMENT AND PLAN OF MERGER


         THIS AGREEMENT AND PLAN OF MERGER dated as of _______ __, 1999 (this
"Agreement"), is among Alkermes, Inc. (the "Parent"), a Pennsylvania
corporation, Alkermes Acquisition Sub, Inc. (the "Acquisition Sub"), a Delaware
corporation and newly formed, wholly owned subsidiary of the Parent, and
Advanced Inhalation Research, Inc. (the "Company"), a Delaware corporation. The
parties wish to effect the acquisition of the Company by the Parent through a
merger of the Acquisition Sub with and into the Company (the "Merger"), on the
terms and conditions hereof. The Merger is intended to be a reorganization
within the meaning of Section 368(a) of the Internal Revenue Code of 1986, as
amended (the "Code"), and the parties intend, by executing this Agreement, to
adopt a plan of reorganization within the meaning of Section 368 of the Code.

         A glossary of defined terms appears in Section 10 of this Agreement and
reference is made to that Section for the definitions of capitalized terms used
herein.

         Now, therefore, in consideration of the mutual representations,
warranties and covenants contained herein, the parties hereto, intending to be
legally bound, hereby agree as follows:

                                    SECTION 1
                                   THE MERGER

         1.1      The Merger. Upon the terms and subject to the conditions
hereof, and in accordance with the General Corporation Law of the State of
Delaware (the "DGCL"), the Acquisition Sub shall be merged with and into the
Company which shall be the surviving corporation (in such capacity hereinafter
called the "Surviving Corporation"), and which shall continue to be governed by
the laws of the State of Delaware. From and after the Effective Time of the
Merger, the corporate existence of the Company, with all its rights, privileges
and immunities, shall continue unaffected and unimpaired by the Merger, and the
corporate existence of the Acquisition Sub, with all its rights, privileges and
immunities, shall be merged into the Company and the Company shall, as the
Surviving Corporation, be fully vested therewith in accordance with the
applicable laws of the State of Delaware. The separate existence and corporate
organization of the Acquisition Sub, except insofar as they may be continued by
law, shall cease upon the Effective Time of the Merger.

         1.2      Effective Time. As soon as practicable after satisfaction or
waiver of all conditions to the Merger, the parties shall cause a certificate of
merger (the "Merger Certificate") in the form attached hereto as Exhibit A to be
filed and recorded in accordance with Section 251 of the DGCL and shall take all
such further actions as may be required by law to make the Merger effective. The
Merger shall be effective at such time as the Merger Certificate is filed with
the Secretary of State of Delaware in accordance with the DGCL or at such later
time as is specified in the Merger Certificate (the "Effective Time").
Immediately prior to the filing of the Merger Certificate, a closing (the
"Closing") will be held at the offices of Palmer & Dodge, LLP, One Beacon
Street, Boston, Massachusetts (or such other place as the parties may agree) for
the purpose of confirming satisfaction or waiver of all conditions to the
Merger. It is intended that the Closing shall take place
<PAGE>   7
on the date hereof but not later than February 1, 1999. The date on which the
Closing occurs is referred to herein as the "Closing Date."

         1.3      Effect of the Merger. The Merger shall have the effect set
forth in Section 259 of the DGCL.

         1.4      Certificate of Incorporation and Bylaws. The Certificate of
Incorporation and Bylaws of the Acquisition Sub, in each case as in effect
immediately prior to the Effective Time, shall be the Certificate of
Incorporation and Bylaws of the Surviving Corporation immediately after the
Effective Time; provided, however, that Article I of the Certificate of
Incorporation of the Surviving Corporation shall be amended to read as follows:
"The name of the corporation is Advanced Inhalation Research, Inc."

         1.5      Directors and Officers. The directors and officers of the
Acquisition Sub (as identified by the Parent) immediately prior to the Effective
Time shall be the directors and officers of the Surviving Corporation
immediately after the Effective Time, each to hold office in accordance with the
Certificate of Incorporation and Bylaws of the Surviving Corporation; provided,
however, that David A. Edwards shall serve as President and Chief Scientific
Officer of the Surviving Corporation. The Board of Directors of the Surviving
Corporation may designate such other officers as it determines. If, at the
Effective Time, a vacancy shall exist in the Board of Directors or in any of the
offices of the Surviving Corporation by reason of death or inability to act, or
for any other reason, such vacancy may be filled in the manner provided in the
Bylaws of the Surviving Corporation.

         1.6      Conversion of Stock.

                  (a) For purposes of this Agreement:

                           (i) "Parent Shares" means the number of shares of
common stock, $0.01 par value, of the Parent to be issued as the Merger
Consideration.

                           (i)(a) "Parent Common Stock" means the common stock,
$0.01 par value per share.

                           (ii) "Closing Market Value" means the average of the
closing prices of Parent Common Stock as reported by the Nasdaq National Market
for the thirty (30) trading days ending on the third trading day prior to the
Closing Date. The Closing Market Value and the number of the Parent Shares to be
issued as part of the Merger Consideration in accordance with Section 1.6
(a)(vii) shall be adjusted, as necessary, to reflect any nontaxable stock split,
reverse stock split, stock dividend or stock combination affecting Parent Common
Stock as a class occurring before the Effective Time.

                           (iii) "Company Common Stock" means all shares of
common stock of the Company, $0.001 par value per share.

                           (iv) "Dissenting Shares" means all shares of Company
Common Stock held by stockholders of the Company who properly exercise appraisal
rights with respect thereto in


                                        2
<PAGE>   8
accordance with Section 262 of the DGCL and who do not subsequently waive,
revoke or otherwise rescind such rights pursuant to Section 262 of the DGCL
either before or after the Effective Time.

                           (v) "Participating Shares" means all shares of
Company Common Stock outstanding at the Effective Time, but excluding all
Dissenting Shares and shares of Company Common Stock held at the Effective Time
by the Company as treasury stock.

                           (vi) "Participating Holders" means the holders of
Participating Shares immediately before the Effective Time (including the
holders of Dissenting Shares immediately before the Effective Time if such
Dissenting Shares later become Participating Shares) or their respective
successors or assigns.

                           (vii) "Merger Consideration" means the shares of
Parent Common Stock issued pursuant to Section 1.6(b)(iii).

                  (b) At the Effective Time, by virtue of the Merger and without
any action on the part of the Parent or the Company:

                           (i) all issued and outstanding shares of Company
Common Stock subject to repurchase and vesting restrictions pursuant to the
Restricted Stock Purchase Agreements among the Company and the stockholders of
the Company who are parties to such agreements (the "Restricted Stock") shall be
entitled to receive the per share Merger Consideration set forth in this Section
1.6(b)(iii); provided, however, that the Surviving Corporation will assume the
Restricted Stock Purchase Agreements and the Parent and each holder of
Restricted Stock shall amend the Restricted Stock Purchase Agreements to provide
the difference in the security and the number of shares of such security covered
by such agreements based on the conversion of Company Common Stock into Parent
Common Stock, and the Merger Consideration applicable to unvested shares of
Restricted Stock shall be placed in escrow pursuant to the terms of an Escrow
Agreement substantially in the form of Exhibit B attached hereto and shall be
distributed in accordance with such stockholder's Restricted Stock Purchase
Agreement, as amended, with the Surviving Corporation and the Parent;

                           (ii) all stock options granted pursuant to the
Company's 1998 Equity Incentive Plan which are outstanding and unexercised
immediately prior to the Effective Time shall cease to represent the right to
acquire shares of Company Common Stock and shall automatically convert into the
right to acquire 1.1829754 shares of Parent Common Stock for each share of
Company Common Stock (provided that the aggregate number of shares of Parent
Common Stock subject to options granted to each optionee resulting from such
conversion shall be rounded down to the nearest whole share) and shall be
subject to the same vesting schedule, exercise price and other restrictions as
set forth in the Option Agreement between the Parent and each such holder (the
adjustment provided herein with respect to any options which are "incentive
stock options" as defined in Section 422 of the Code shall be and is intended to
be effected in a manner which is consistent with Section 424(a) of the Code.);

                           (iii) each issued and outstanding share of Company
Common Stock held by the Participating Holders as of the Effective Time shall be
converted into and become the right to


                                        3
<PAGE>   9
receive 1.1829754 shares of Parent Common Stock as the Merger Consideration. The
Participating Holders shall have the right to the benefits of and to enforce the
covenants and indemnification obligations of the Parent and the Acquisition Sub
under the Agreement with the Company's Stockholders as attached hereto as
Exhibit C and made a part hereof;

                           (iv) all shares of Company Common Stock held at the
Effective Time by the Company as treasury stock shall be canceled and no payment
shall be made with respect thereto;

                           (v) holders of Dissenting Shares shall cease to have
any stockholder rights with respect to their Dissenting Shares except the right
to be paid the fair value of their Dissenting Shares and any other rights under
Section 262 of the DGCL; and

                           (vi) all Parent Shares constituting the Merger
Consideration shall be deemed to have been issued as of the Effective Time.

                           (vii) each share of common stock, $0.01 par value, of
the Acquisition Sub outstanding immediately prior to the Effective Time shall,
at such time, be converted into and exchanged for one share of Common Stock, par
value $0.01 per share, of the Surviving Corporation.

         1.7      Closing of Company Transfer Books. At the Effective Time, the
stock transfer books of the Company shall be closed and no transfer of Company
Common Stock shall thereafter be made. If, after the Effective Time,
certificates representing shares of Company Common Stock are presented to the
Surviving Corporation, they shall be canceled and presented to the Exchange
Agent in accordance with Section 1.9.

         1.8      Dissenting Shares.

                  (a) Dissenting Shares shall not be entitled to receive the
Merger Consideration. From and after the Effective Time, each holder of
Dissenting Shares (except to the extent that such Dissenting Shares become
Participating Shares after the Effective Time in which case such Dissenting
Shares shall be treated in the same manner that they would have been treated had
they been Participating Shares as of the Effective Time), shall no longer retain
any rights of a stockholder of the Company or the Surviving Corporation, except
those provided under the DGCL.

                  (b) The Company shall give the Parent (i) prompt notice of any
written demands under Section 262 of the DGCL with respect to any shares of
capital stock of the Company, any withdrawal of any such demands and any other
instruments served pursuant to the DGCL and received by the Company and (ii) the
right to participate in all negotiations and proceedings with respect to any
demands under Section 262 of the DGCL with respect to any shares of capital
stock of the Company. The Company shall cooperate with the Parent concerning,
and shall not, except with the prior written consent of the Parent, voluntarily
make any payment with respect to, or offer to settle or settle, any such
demands.

                  (c) Following the Merger, the Surviving Corporation shall, and
the Parent shall cause the Surviving Corporation to, comply with the DGCL to
satisfy the obligations of the Acquisition Sub and the Company with respect to
any stockholders who did not consent to the


                                        4
<PAGE>   10
Merger and to the Dissenting Shares. To the extent that any payment made by the
Surviving Corporation pursuant to this Section 1.8(c) would cause the Surviving
Corporation to hold less than 90 percent of the fair market value of the net
assets or less than 70 percent of the fair market value of the gross assets held
by the Company immediately prior to the Merger, the Parent shall make such
payment (or shall contribute funds to the Surviving Corporation to make such
payment). For this purpose, amounts paid by the Company to stockholders who
receive cash or other property (including, but not limited to, amounts paid to
holders of Dissenting Shares and cash paid in lieu of the issuance of fractional
shares), amounts used by the Company to pay reorganization expenses, and all
redemptions and distributions (except for regular, normal dividends) made by the
Company in connection with the Merger or during the period beginning with the
commencement of negotiations (whether formal or informal) regarding the Merger
and ending immediately before the Effective Time will be included as assets of
the Company held immediately prior to the Merger.

                  (d) If, following the Effective Time, any Dissenting Shares
become Participating Shares, the Parent shall deposit with the Exchange Agent,
the amount of Merger Consideration payable to such new Participating Holder(s)
and, such deposit shall include (A) any dividends or other distributions payable
following the Effective Time with respect to such Parent Shares, and (B) any
cash payable in lieu of fractional shares in accordance with Section 1.10. As
soon as practicable thereafter, such Participating Shares will be presented to
the Exchange Agent in accordance with Section 1.9.

         1.9      Exchange of Certificates. The Parent shall authorize one or
more Persons to act as Exchange Agent hereunder (the "Exchange Agent"). As soon
as practicable after the Effective Time, the Parent shall cause the Exchange
Agent to mail to all Participating Holders instructions for surrendering their
certificates representing Company Common Stock in exchange for the Merger
Consideration. Upon surrender of a certificate representing Company Common Stock
for cancellation to the Exchange Agent or to such other agent or agents as may
be appointed by the Parent, the holder of such certificate shall be entitled to
receive in exchange therefor the amount of the Merger Consideration into which
the shares represented by such certificate shall have been converted pursuant to
the provisions of this Agreement, and the certificate so surrendered shall
forthwith be canceled. Until surrendered in accordance with the provisions of
this Section 1.9, each Company Common Stock certificate (other than certificates
evidencing shares to be canceled in accordance with Section 1.6(b)(iv) and
Dissenting Shares, if any) shall represent for all purposes the right to receive
its proportionate share of the Merger Consideration. If any Parent Common Stock
certificates are to be issued in a name other than that in which the Company
Common Stock certificate surrendered is registered, it shall be a condition of
such exchange that the Person requesting such exchange shall deliver to the
Exchange Agent all documents necessary to evidence and effect such transfer and
shall pay to the Exchange Agent any transfer or other taxes required by reason
of the issuance of certificates for such Parent Shares in a name other than that
of the registered holder of the certificate surrendered or establish to the
satisfaction of the Exchange Agent that such tax has been paid or is not
applicable.

         1.10     No Fractional Shares. No certificates representing fractional
Parent Shares shall be issued upon the surrender for exchange of Company Common
Stock certificates. No fractional interest shall entitle the owner to vote or to
any rights of a security holder. In lieu of fractional


                                        5
<PAGE>   11
shares, each holder of shares of Company Common Stock who would otherwise have
been entitled to a fractional Parent Share, will receive upon surrender of a
Company Common Stock certificate or certificates, as the case may be, an amount
in cash (without interest) determined by multiplying such fraction by the
Closing Market Value of one share of Parent Common Stock (determined in
accordance with Section 1.6(a)(ii)). The Parent shall not be liable to any
holder of shares of Company Common Stock for any cash in lieu of fractional
interests delivered to a public official pursuant to applicable escheat or
abandoned property laws.


                                    SECTION 2
                    REPRESENTATIONS AND WARRANTIES OF COMPANY

         The Company hereby makes the following representations, warranties and
agreements to and with the Parent and the Acquisition Sub. The Company
represents and warrants to the Parent and the Acquisition Sub that the
statements contained in this Section 2 are correct and complete as of the date
of this Agreement and will be correct and complete on the Closing Date (as
though made then and as though the Closing Date were substituted for the date of
this Agreement throughout this Section 2), except as set forth in the disclosure
schedule of the Company accompanying this Agreement (the "Company Disclosure
Schedule"), the section numbers of which are numbered to correspond to the
section numbers of this Agreement to which they refer, and except as permitted
under or contemplated by this Agreement. For the purposes of this Section 2, the
phrase "to the best knowledge of the Company" or similar expression means the
actual conscious knowledge of David A. Edwards, Robert S. Langer, Terrance
McGuire, Ralph W. Niven, Markus Cappel or any of them.

         2.1      Organization and Qualification.

                  (a) The Company is a corporation duly organized, validly
existing and in good standing under the laws of its state of incorporation with
full corporate or other power and authority to own, lease and operate its assets
and properties and to carry on its business as now being and as heretofore
conducted. The Company is qualified or otherwise authorized to transact business
as a foreign corporation in all jurisdictions in which such qualification or
authorization is required by law, except for jurisdictions in which the failure
to be so qualified or authorized would not have a material adverse effect on the
assets, properties, business, research, development and other activities of the
Company as currently conducted or currently proposed to be conducted, prospects,
results of operation, cash flow or financial condition of the Company (the
"Business of Company").

                  (b) The Company has previously provided to the Parent true and
complete copies of the Certificate of Incorporation, as amended, and Bylaws as
presently in effect, and the Company is not in default in the performance,
observation or fulfillment of its charter or bylaws or other governing
instruments. The minute books of the Company contain reasonably accurate records
of the meetings and consents in lieu of meetings of the Board of Directors (and
any committees thereof) and of the stockholders since the time of the Company's
incorporation and accurately reflect in all material respects all transactions
referred to in such minutes and consents in lieu of meetings. The stock books of
the Company are true and complete.


                                        6
<PAGE>   12
         2.2      Authority to Execute and Perform Agreements. The Company has
the corporate power and authority to enter into, execute and deliver this
Agreement and to perform fully its obligations hereunder. The execution and
delivery of this Agreement and the consummation of the transactions contemplated
hereby have been duly authorized by the Board of Directors of the Company and
adopted and approved by the stockholders of the Company. No other action on the
part of the Company is necessary to consummate the transactions contemplated
hereby (other than the filing and recording of the Merger Certificate in
accordance with the DGCL). This Agreement has been duly executed and delivered
by the Company and, subject to the foregoing, constitutes a valid and binding
obligation of the Company, enforceable in accordance with its terms.

         2.3      Capitalization and Title to Shares.

                  (a) As of the date hereof, and not as of the Closing Date, the
Company is authorized to issue 3,700,000 shares of Company Common Stock, of
which 2,195,292 shares are issued and outstanding, and 915,952 shares of
Preferred Stock, $0.001 par value per share, issuable in series ( "Company
Preferred Stock"). Of such Company Preferred Stock, as of the date hereof and
not the Closing Date, 250,000 shares have been designated Series A Convertible
Preferred Stock, all which are issued and outstanding; 250,000 shares have been
designated Series AA Convertible Preferred Stock, all of which are issued and
outstanding; 170,648 shares have been designated as Series B Convertible
Preferred Stock, all of which shares are issued and outstanding; 184,366 shares
have been designated as Series C Convertible Preferred Stock, all of which are
issued and outstanding; and 60,938 have been designated as Series D Convertible
Preferred Stock, all of which are issued and outstanding. Immediately prior to
the Effective Time, the Company will be authorized to issue 3,700,000 shares of
Company Common Stock, of which 3,111,244 shares will be issued and outstanding,
and 915,952 shares of Company Preferred Stock, none of which will be issued and
outstanding. The Company Disclosure Schedule sets forth the record owners of all
shares of Company Common Stock and Company Preferred Stock, along with the
amounts of such shares held by such record owners on the date hereof and
immediately prior to the Effective Time. No other class of capital stock of the
Company is authorized or outstanding. All of the issued and outstanding shares
of the Company's capital stock are, and immediately prior to the Effective Time
will be, duly authorized and are, and immediately prior to the Effective Time
will be, validly issued, fully paid, nonassessable and free of preemptive
rights. All outstanding shares of Company Common Stock and Company Preferred
Stock and all options and warrants to purchase Company Common Stock and Company
Preferred Stock have been issued in compliance with all applicable federal and
state securities laws.

                  (b) The Company Disclosure Schedule includes a true and
complete list of all outstanding rights, subscriptions, warrants, calls,
preemptive rights, options or other agreements of any kind to purchase or
otherwise receive from the Company any shares of the capital stock or any other
security of the Company, and all outstanding securities of any kind convertible
into or exchangeable or exercisable for such securities. Except as set forth in
the Company Disclosure Schedule, there are no shareholder agreements, voting
trusts, proxies or other agreements, instruments or understandings with respect
to the outstanding shares of capital stock of the Company to which the Company
is a party.


                                        7
<PAGE>   13
                  (c) The Company does not own beneficially any shares of
capital stock of the Parent.

                  (d) All warrants exercisable for shares of Company Common
Stock or Company Preferred Stock have been exercised in full.

         2.4      Subsidiaries and Other Affiliates.

                  (a) The Company does not have any Subsidiaries.

                  (b) The Company does not directly or indirectly own or have
any investment in any of the capital stock of, and is not a party to a
partnership or joint venture with, any other Person.

         2.5      Financial Statements. The Company has previously delivered to
the Parent (i) the unaudited financial statements of the Company for the periods
ended December 31, 1997 and September 30, 1998 (the "Financial Statements"). The
Financial Statements have been prepared in accordance with generally accepted
accounting principles, consistently applied ("GAAP") and have been prepared
from, and are in accordance with, the books and records of the Company and
present fairly the financial position and the results of operations of the
Company as of the dates and for the periods indicated.

         2.6      Absence of Undisclosed Liabilities. As at September 30, 1998,
the Company had no liabilities of any nature, whether accrued, absolute,
contingent or otherwise (including, without limitation, liabilities as guarantor
or otherwise with respect to obligations of others or liabilities for Taxes due
or then accrued or to become due), required to be reflected or disclosed in the
balance sheet contained in such Financial Statements that were not adequately
reflected or reserved against on the balance sheet contained in such Financial
Statements. The Company has no such liabilities, other than liabilities (i)
adequately reflected or reserved against on the balance sheet contained in such
Financial Statements, (ii) incurred since September 30, 1998 in the ordinary
course of business, (iii) disclosed in this Agreement, or (iv) that would not,
in the aggregate, have a material adverse effect on the Business of Company.

         2.7      No Material Adverse Change. Since September 30, 1998, except
as described in the Financial Statements, there has not been:

                  (a) Any material adverse change in the Business of Company;

                  (b) Any transaction, commitment, contract or agreement entered
into by the Company or any relinquishment by the Company of any contract or
other right having a value of or involving aggregate payments in excess of
$25,000;

                  (c) Any issuance of capital stock of the Company or any
option, warrant or other right to purchase or otherwise acquire capital stock of
the Company, except for issuances of stock upon the conversion of Company
Preferred Stock, the exercise of outstanding warrants and options and any newly
granted options set forth in the Company Disclosure Schedule;


                                        8
<PAGE>   14
                  (d) Any redemption or other acquisition of any capital stock
of the Company or any declaration, setting aside, or payment of any dividend or
distribution of any kind with respect to any shares of capital stock of the
Company;

                  (e) Any increase in compensation, bonus or other benefits
payable or to become payable by the Company to any of its directors, officers or
employees;

                  (f) Any new employee benefit, deferred compensation or other
similar employee benefit arrangement, or any new employment or consulting
arrangement or any grant of any severance or termination rights to any director,
officer or employee of the Company or any increase in benefits payable under
existing severance or termination pay policies or employment agreements;

                  (g) Any change in any accounting method or practice followed
by the Company;

                  (h) Any making by the Company of any loan or advance to any
stockholder, officer, director or consultant (other than expense advances made
in the ordinary course of business), or any other loan or advance otherwise than
in the ordinary course of business;

                  (i) Except for inventory or equipment acquired in the ordinary
course of business, any acquisition by the Company of all or any part of the
assets, properties, capital stock or business of any other Person;

                  (j) Except in the ordinary course of business, any sale,
abandonment or any other disposition of any of the Company's assets or
properties; or

                  (k) Any commitment on the part of the Company to do any of the
foregoing.

         2.8      Tax Matters.

                  (a) The Company has filed all Tax reports and returns required
to be filed by it and has paid or will timely pay all Taxes and other charges
shown as due on such reports and returns. All positions taken in such Tax
reports and returns that could give rise to a substantial understatement penalty
within the meaning of Section 6662 of the Code have been disclosed therein. The
Company is not delinquent in the payment of any material Tax assessment or other
governmental charge (including without limitation applicable withholding taxes).
Any provision for Taxes reflected in the Financial Statements is adequate for
payment of any and all Tax liabilities for periods ending on or before September
30, 1998 and there are no Tax liens on any assets of the Company except liens
for current Taxes not yet due.

                  (b) There has not been any audit of any Tax return filed by
the Company and to the best knowledge of the Company, no audit of any such Tax
return is in progress and the Company has not been notified by any Tax authority
that any such audit is contemplated or pending. The Company knows of no Tax
deficiency or claim for additional Taxes asserted or threatened to be asserted
against the Company by any Taxing authority and the Company knows of no grounds
for any such assessment. No extension of time with respect to any date on which
a Tax return was or is to be filed by the Company is in force, and no waiver or
agreement by the Company


                                        9
<PAGE>   15
is in force for the extension of time for the assessment or payment of any Tax.
For purposes of this Agreement, the term "Tax" includes all federal, state,
local and foreign taxes or assessments, including income, sales, gross receipts,
excise, use, value added, royalty, franchise, payroll, withholding, property and
import taxes and any interest or penalties applicable thereto.

                  (c) The Company (i) has not been a member of an "affiliated
group" filing a consolidated federal income tax return (other than a group the
common parent of which was the Company) or (ii) does not have any liability for
the Taxes of any Person (other than the Taxes of the Company) under Treas. Reg.
Section1.1502-6 (or any similar provision of state, local or foreign law), as a
transferee or successor, by contract, or otherwise.

                  (d) No election under Section 336(e) or Section 338 of the
Code has been made with respect to the Company.

                  (e) No consent pursuant to Section 341(f) of the Code is in
effect that relates to the Company.

                  (f) The Company is not and has not been a United States real
property holding corporation within the meaning of Section 897(c)(2) of the Code
during the applicable period specified in Section 897(c)(1)(A)(ii) of the Code.
The Parent shall have received (a) a certification from the Company, dated no
more than thirty (30) days prior to the Closing Date and signed by a responsible
corporate officer of the Company, that the Company is not, and has not been at
any time during the five years preceding the date of such certification, a
United States real property holding company, as defined in Section 897(c)(2) of
the Code, and (b) proof reasonably satisfactory to the Parent that the Company
has provided notice of such certification to the IRS in accordance with the
provisions of Treasury regulations Section 1.897-2(h)(2).

                  (g) The Company has not entered into any compensatory
agreements with respect to the performance of services for which payment
thereunder would result in a nondeductible expense to the Company pursuant to
Section 280G of the Code.

                  (h) The Company has not agreed, nor is it required, to make
any adjustment under Section 481(a) of the Code by reason of a change in
accounting method or otherwise.

         2.9      Compliance with Laws.

                  (a) The Company has all licenses, certifications, approvals,
qualifications, variances, permissive uses, consents and other authorizations
(collectively, "Permits") material to the conduct of its business as currently
conducted or as reasonably expected to be conducted. Such Permits are in full
force and effect; any applications for renewal necessary to maintain any Permit
in effect have been filed; and no proceeding is pending, or to the best
knowledge of the Company, threatened to revoke or limit any Permit.

                  (b) The Company is not in violation of any applicable law,
ordinance or regulation or any order, judgment, injunction, decree or other
requirement of any court, arbitrator or governmental or regulatory body, except
for violations that would not, in the aggregate, have a


                                       10
<PAGE>   16
material adverse effect on the Business of Company. Since its incorporation, the
Company has not received notice of, and there has not been any citation, fine or
penalty imposed against the Company for, any such violation or alleged
violation.

         2.10     No Breach.

                  (a) Except for the filing of the Merger Certificate with the
State of Delaware, the execution, delivery and performance of this Agreement by
the Company and the consummation by the Company of the transactions contemplated
hereby will not (i) violate any provision of the Certificate of Incorporation or
Bylaws of the Company; (ii) violate, conflict with or result in the breach of
any of the terms or conditions of, result in modification of the effect of, or
otherwise give any other contracting party the right to terminate, or constitute
(or with notice or lapse of time or both constitute) a default under, any
instrument, contract or other agreement to which the Company is a party or to
which it or any of its assets or properties is bound or subject; (iii) violate
any law, ordinance or regulation or any order, judgment, injunction, decree or
other requirement of any court, arbitrator or governmental or regulatory body
applicable to the Company or by which any of the Company's assets, properties or
securities is bound; (iv) violate any Permit; (v) require any filing with,
notice to, or permit, consent or approval of, any other governmental or
regulatory body; or (vi) result in the creation of any lien or other encumbrance
on the assets, properties or securities of the Company, excluding from the
foregoing clauses (ii), (iii), (iv), (v) and (vi) any exceptions to the
foregoing that, in the aggregate, would not have a material adverse effect on
the Business of Company or on the ability of the Company to consummate the
transactions contemplated hereby.

                  (b) No filing of a premerger notification form pursuant to the
HSR Act is required on the part of the Company or any stockholder of the
Company.

         2.11     Actions and Proceedings. There are no outstanding orders,
awards, judgments, injunctions, decrees or other requirements of any court,
arbitrator or governmental or regulatory body against the Company or any of its
securities, assets or properties. There are no actions, suits, investigations or
claims or legal, administrative or arbitration proceedings pending or, to the
best knowledge of the Company, threatened against the Company that individually
or in the aggregate would have a material adverse effect upon the transactions
contemplated hereby or the Business of Company. To the best knowledge of the
Company, there is no fact, event or circumstance now in existence that
reasonably could be expected to give rise to any action, suit, claim, proceeding
or investigation that individually or in the aggregate would have a material
adverse effect upon the transactions contemplated hereby or on the Business of
Company.

         2.12     Contracts and Other Agreements. The Company Disclosure
Schedule sets forth a list of all contracts and other agreements to which the
Company is a party or by or to which it or its assets or properties are bound or
subject, whether or not made in the ordinary course of business, that have or
would be reasonably expected to have a material effect on the Business of
Company.

         True and complete copies of all the contracts and other agreements (and
all amendments, waivers or other modifications thereto) set forth on the Company
Disclosure Schedule have been furnished to the Parent. Each of such contracts is
valid, subsisting, in full force and effect, binding upon the Company, and to
the best knowledge of the Company, binding upon the other parties


                                       11
<PAGE>   17
thereto in accordance with their terms, and the Company is not in default under
any of them, nor, to the best knowledge of the Company, is any other party to
any such contract or other agreement in default thereunder, nor does any
condition, exist that with notice or lapse of time or both would constitute a
default thereunder, except, in each case, such defaults as would not,
individually or in the aggregate, have a material adverse effect on the Business
of Company.

         The Company has no knowledge of any intent of any third party to any of
the contracts and agreements described above to default, breach, terminate,
suspend or modify in a material way any such contract or agreement with the
Company at any time prior to or in connection with the Closing.

         2.13     Bank Accounts and Powers of Attorney. The Company Disclosure
Schedule identifies all bank and brokerage accounts of the Company, whether or
not such accounts are held in the name of the Company, lists the respective
signatories therefor and lists the names of all Persons holding a power of
attorney from the Company and a summary of the terms thereof.

         2.14     Properties.

                  (a) The Company owns and has good title to all of its assets
and properties reflected as owned on the Financial Statements, free and clear of
any lien, claim or other encumbrance, except for (i) the liens, claims or other
encumbrances, (ii) assets and properties disposed of, or subject to purchase or
sales orders, in the ordinary course of business since September 30, 1998, (iii)
liens or other encumbrances securing the liens of materialmen, carriers,
landlords and like Persons, all of which are not yet due and payable, (iv) liens
for Taxes not yet delinquent and (v) liens, claims or other encumbrances that,
in the aggregate, are not material to the Business of Company.

                  (b) The Company does not own any real property and does not
have any options or contractual obligations to purchase or acquire any interest
in real property. The Company has a valid leasehold interest in all of the
buildings, structures and leasehold improvements adequate to conduct the
business of the Company, and owns or has a valid leasehold interest in all
equipment and other tangible property material to the conduct of its business,
all of which are in good and sufficient operating condition and repair, ordinary
wear and tear excepted. All leasehold interests in any real property held by the
Company are in the Commonwealth of Massachusetts. All such current leases are in
full force and effect, and there is not, under any of such leases, any existing
default or event of default (or event which with notice or lapse or time, or
both, would constitute a default). There is no equipment located on the premises
of the Company that is on loan from another party.

         2.15     Intellectual Property. Set forth in the Company Disclosure
Schedule is a complete and accurate list of all patents, trademarks, service
marks, trade names, logos, franchises, inventions disclosed to the Company but
not included in patent applications, and copyrights, and all applications for
any of the foregoing, which are owned by the Company or in which the Company has
license rights (the "Listed Rights"), including the nature of each Listed Right,
e.g. ownership, exclusive or nonexclusive license. The Company owns or has
license rights to all technology, any inventions made by employees of the
Company in the course of their employment by the Company


                                       12
<PAGE>   18
and not included as a Listed Right, trade secrets, know-how, computer software
and processes used in, to be used in, or necessary for the conduct of the
Business of Company as presently conducted or presently contemplated to be
conducted (such proprietary rights, collectively with the Listed Rights, are
referred to as the "Proprietary Rights"). The Company has sole ownership of the
Listed Rights, except as set forth on the Company Disclosure Schedule. The
Company is not aware of any claim by any third party that the Business of
Company infringes upon any proprietary rights of others, nor has the Company
received any notice or claim from any third party of such infringement by the
Company. The Company is not aware of any infringement by any third party on, or
any competing claim of right to use or own any of, the Listed Rights. The
Company is not aware of any claim asserted by a third party of the right to use
or own any of the Proprietary Rights to the exclusion of the Company. The
Company has the right to use, free and clear of claims or rights of others, all
customer lists and computer software used in the Business of Company. With
respect to patents and patent applications, the Company's ownership has been or
will be in a timely fashion properly recorded in the assignment records of the
United States Patent and Trademark Office and in relevant corresponding foreign
patent offices. To the Company's knowledge, there are no facts which would
preclude the grant of a patent from each of the patent applications listed in
the Company Disclosure Schedule, the Company has complied with the United States
Patent and Trademark Office's duty of candor and disclosure for each of the
United States utility patents and patent applications listed in the Company
Disclosure Schedule, and there are no facts which form a basis for a finding of
unenforceability or invalidity of any of the claims of the patents and patent
applications listed in the Company Disclosure Schedule. To the knowledge of the
Company, none of the activities of the employees of the Company on behalf of the
Company violates any agreement or arrangement which such employees have with
former employers.

         2.16     Employee Benefit Plans. The Company Disclosure Schedule sets
forth a complete list of all pension, profit sharing, retirement, deferred
compensation, welfare, insurance, disability, bonus, vacation pay, severance pay
and similar plans, programs or arrangements, including without limitation all
employee benefit plans as defined in Section 3(3) of the Employee Retirement
Income Security Act of 1974, as amended ("ERISA") (the "Plans") maintained by
the Company. The Company does not maintain or contribute to any "Multiemployer
Plan" as defined in Section 4001(a)(3) of ERISA, and the Company has not
incurred any material liability under Sections 4062, 4063 or 4201 of ERISA. Each
Plan maintained by the Company which is intended to be qualified under either
Section 401(a) or 501(c)(9) of the Code ("Qualified Plans") is so qualified.
Each Plan has been administered in all material respects in accordance with the
terms of such Plan and the provisions of any and all statutes, orders or
governmental rules or regulations, including without limitation ERISA and the
Code, and to the knowledge of the Company nothing has been done or omitted to be
done with respect to any Plan that would result in any material liability on the
part of the Company under Title I of ERISA or Section 4975 of the Code. All
reports required to be filed with respect to all Plans, including without
limitation annual reports on Form 5500, have been timely filed except where the
failure to so file would not have a material adverse effect on the Business of
Company. No "reportable event" as defined in Section 4043 of ERISA, other than
any such event for which the thirty-day notice period has been waived, has
occurred with respect to any pension plan subject to Title IV of ERISA. With
respect to all pension plans subject to Title IV of ERISA, such plans have no
unfunded benefit liabilities, all contributions to such plans under the minimum
funding requirements of Section 412 of the Code have been made and all premium


                                       13
<PAGE>   19
payments to the Pension Benefit Guaranty Corporation with respect to such plans
have been made. All claims for welfare benefits incurred by employees on or
before the Closing are or will be fully covered by third-party insurance
policies or programs. Except for continuation of health coverage to the extent
required under Section 4980B of the Code or applicable state law or as otherwise
set forth in this Agreement, there are no obligations under any welfare plan
providing benefits after termination of employment.

         2.17     Employee Relations. The Company has approximately 29 full-time
equivalent employees and generally enjoys good employer-employee relations. The
Company is not delinquent in payments to any of its employees or consultants for
any wages, salaries, commissions, bonuses or other direct compensation for any
services performed by them to the date hereof or amounts required to be
reimbursed to such employees. Upon termination of the employment of any
employees, neither the Company nor the Parent or the Surviving Corporation will
by reason of the Merger or anything done prior to the Effective Time be liable
to any of such employees for severance pay or any other payments (other than
accrued salary, vacation or sick pay in accordance with the Company's normal
policies). True and complete information as to all current directors, officers,
employees or consultants of the Company including, in each case, name, current
job title, base salary, bonus potential, commissions and termination obligations
has been previously furnished to the Parent.

         2.18     Section 83(b) Election. All holders of Restricted Stock of the
Company filed an election under Section 83(b) of the Code with the Internal
Revenue Service not later than thirty (30) days after the date of purchase of
such Restricted Stock.

         2.19     Insurance. The Company Disclosure Schedule sets forth a list
of all policies or binders of fire, liability, product liability, workers'
compensation, vehicular, directors' and officers' and other insurance held by or
on behalf of the Company. Such policies and binders are in full force and
effect, are reasonably believed to be adequate for the businesses engaged in by
the Company, and are in conformity with the requirements of all leases or other
agreements to which the Company is a party and, to the best knowledge of the
Company, are valid and enforceable in accordance with their terms. The Company
is not in default with respect to any provision contained in any such policy or
binder nor has the Company failed to give any notice or present any claim under
any such policy or binder in due and timely fashion. There are no outstanding
unpaid claims under any such policy or binder. The Company has not received
notice of cancellation or non-renewal of any such policy or binder.

         2.20     Brokerage. No broker, finder, agent or similar intermediary
has acted on behalf of the Company in connection with this Agreement or the
transactions contemplated hereby, and there are no brokerage commissions,
finders' fees or similar fees or commissions payable in connection herewith
based on any agreement, arrangement or understanding with the Company, including
but not limited to fees owed to SG Cowen Securities Corporation under that
certain letter agreement between SG Cowen and the Company dated August 17, 1998.


                                       14
<PAGE>   20
         2.21     Hazardous Materials.

                  (a) There are and have been no Hazardous Materials generated,
used, handled or stored by the Company, the proper disposal of which will
require any material expenditure by the Company. There has been no generation,
use, handling, storage or disposal of any Hazardous Materials in violation of
common law or any applicable environmental law at any premises leased by the
Company during the period of the Company's lease, nor has there been or is there
threatened any release of any Hazardous Materials on or at any such premises
during such period in violation of common law or any applicable environmental
law or which created or will create an obligation to report or remediate such
release. "Hazardous Materials" means any "hazardous waste" as defined in either
the United States Resource Conservation and Recovery Act or regulations adopted
pursuant to said Act, and also any "hazardous substances" or "hazardous
materials" as defined in the United States Comprehensive Environmental Response,
Compensation and Liability Act and "oil" as defined in the Oil Pollution Act of
1990.

                  (b) There is no environmental or health and safety matter that
could have a material adverse effect on the Business of Company.

         2.22     Year 2000 Compliance. Each significant system, comprised of
software, hardware, databases, or embedded control systems (microprocessor
controlled, robotic or other devices) (each a "System"), that constitutes any
part of, or which is under control of the Company and is used in connection with
the use, operation or enjoyment of any material tangible or intangible asset or
real property of the Company (a) accurately processes date/time data (including,
but not limited to, calculating, comparing and sequencing) from, into, and
between the twentieth and twenty first centuries, and the years 1999 and 2000
and leap year calculations, to the extent that other systems properly exchange
date/time data with the Company's systems and (b) will not be adversely affected
by the advent of the year 2000 or 2001, the advent of the twenty-first century
or the transition from the twentieth century through the year 2000 and into the
twenty-first century (collectively, items (a) and (b) are referred to herein as
"Year 2000 Compliant"). No System that is material to the business, finances, or
operations of the Company receives data from or communications with any
component or system external to itself (whether or not such external component
or system is the Company's or any third party's) that is not itself Year 2000
Compliant excepting the parts of the external component or system within which
noncompliance will have no effect on the data or communications sent to the
Company, nor on the Systems of the Company. All licenses for the use of any
System-related software, hardware, databases or embedded controls under the
Company's control are certified by the manufacturer to be Year 2000 Compliant
and to contain the capabilities required to enable them to be Year 2000
Compliant within the Company's computer systems (hardware and software), or the
licenses permit the Company or a third party to make all modifications,
bypasses, de-bugging, work-arounds, repairs, replacements, conversions or
corrections necessary to permit the Systems to operate compatibly, in
conformance with their respective specifications, and to be Year 2000 Compliant.
Except as set forth in the Company Disclosure Schedule, the Company has no
reason to believe that it may incur material expenses or that there may be a
material adverse effect on the Business of Company arising from or relating to
the failure of any of its Systems as a result of not being Year 2000 Compliant.


                                       15
<PAGE>   21
         2.23     Disclosure. The representations and warranties and statements
of the Company contained in this Agreement do not contain, and will not contain
at the Closing Date, any untrue statement of a material fact, and do not omit,
and will not omit at the Closing Date, to state any material fact necessary to
make such representations, warranties and statements, in light of the
circumstances under which they are made, not misleading. There is no fact known
to the Company that has not been disclosed to the Parent in this Agreement that
is reasonably likely to have a material adverse effect on the Business of
Company.

         2.24     M.I.T. Agreement Compliance. The Company has complied with all
of its obligations under the Patent License Agreement (the "M.I.T. Agreement")
effective August 11, 1997 between the Massachusetts Institute of Technology and
the Company, as amended, required to be performed on or prior to the date hereof
and the Closing Date. In addition, the Company has achieved the milestones set
forth in Section 3.2(a), (b), (c), (e) and (f) and Section 3.2(d) (for 1998) of
the M.I.T. Agreement.


                                    SECTION 3
        REPRESENTATIONS AND WARRANTIES OF PARENT AND THE ACQUISITION SUB

         The Parent, regarding itself and the Acquisition Sub, and the
Acquisition Sub, regarding itself, hereby make the following representations,
warranties and agreements to and with the Company. The Parent and the
Acquisition Sub represent and warrant to the Company that the statements
contained in this Section 3 are correct and complete as of the date of this
Agreement and will be correct and complete on the Closing Date (as though made
then and as though the Closing Date were substituted for the date of this
Agreement throughout this Section 3), except as set forth in the disclosure
schedule of the Parent accompanying this Agreement (the "Parent Disclosure
Schedule"), the section numbers of which are numbered to correspond to the
section numbers of this Agreement to which they refer. For purposes of this
Section 3, the phrase "to the best knowledge" or similar expression means the
actual conscious knowledge of the directors and executive officers of the Parent
and the Acquisition Sub or any of them.

         3.1      Organization and Qualification.

                  (a) The Parent and the Acquisition Sub are each a corporation
duly organized, validly existing and in good standing or validly subsisting
(with respect to jurisdictions which recognize such concept) under the laws of
their respective state or jurisdiction of incorporation with full corporate or
other power and authority to own, lease and operate their respective assets and
properties and to carry on their respective businesses as now being and as
heretofore conducted. The Parent and the Acquisition Sub are each qualified or
otherwise authorized to transact business as a foreign corporation in all
jurisdictions in which such qualification or authorization is required by law,
except for jurisdictions in which the failure to be so qualified or authorized
would not have material adverse effect on the assets, properties, business,
results of operations or financial condition of the Parent and its Subsidiaries,
including the Acquisition Sub, taken as a whole (the "Business of Parent").


                                       16
<PAGE>   22
                  (b) The Parent has previously provided to the Company true and
complete copies of the charter and bylaws or other governing instruments of the
Parent and the Acquisition Sub as presently in effect, and neither the Parent
nor the Acquisition Sub is in default in the performance, observation or
fulfillment of its respective charter or bylaws or other governing instruments.
The minute books of the Parent and the Acquisition Sub contain reasonably
accurate records of the meetings and consents in lieu of meetings of the Board
of Directors (and any committees thereof) and of the shareholders since the time
of the Parent's and the Acquisition Sub's incorporation and accurately reflect
in all material respects all transactions referred to in such minutes and
consents in lieu of meetings.

                  (c) Acquisition Sub is a newly-formed entity, formed solely
for the purpose of carrying out the transactions contemplated by this Agreement,
and has no other assets or activities.

         3.2      Authority to Execute and Perform Agreements. The Parent and
the Acquisition Sub each have the corporate power and authority to enter into,
execute and deliver this Agreement and to perform fully their respective
obligations hereunder. The execution and delivery of this Agreement and the
consummation of the transactions contemplated hereby have been duly authorized
by the Board of Directors of the Parent and the Acquisition Sub and the sole
stockholder of the Acquisition Sub. No other action on the part of the Parent or
the Acquisition Sub is necessary to consummate the transactions contemplated
hereby. This Agreement has been duly executed and delivered by the Parent and
the Acquisition Sub and, subject to the foregoing, constitutes a valid and
binding obligation of the Parent and the Acquisition Sub, enforceable in
accordance with its terms.

         3.3      Capitalization.

                  (a) The Parent is authorized to issue 40,000,000 shares of
Parent Common Stock, of which 21,170,081 shares were issued and outstanding and
3,881,940 shares were reserved for issuance upon conversion of the outstanding
shares of $3.25 Convertible Exchangeable Preferred Stock as of December 31,
1998, 2,700,000 shares of capital stock, $0.01 par value, issuable in series,
none of which is issued and outstanding and 2,300,000 shares of $3.25
Convertible Exchangeable Preferred Stock, par value $0.01 per share
(collectively, the "Parent Preferred Stock"), of which 2,300,000 shares were
issued and outstanding as of December 31, 1998. The Acquisition Sub is
authorized to issue 100 shares of common stock, $0.01 par value, all of which
are issued and outstanding. As of December 31, 1998, except for an aggregate of
3,640,672 shares of Parent Common Stock authorized for issuance (but unissued)
under various stock option and stock award plans of the Parent, outstanding
1992, 1994 and 1995 Class A Warrants and the 1994 Class B Warrant to purchase
1,022,593 shares of Parent Common Stock and a certain number of shares of Parent
Common Stock that Genentech could, under certain circumstances, demand to
receive in satisfaction of a $3.5 million note by Parent to Genentech dated
January 31, 1995, there is no outstanding right, subscription, warrant, call,
preemptive right, option or other agreement of any kind to purchase or otherwise
to receive from the Parent any shares of the capital stock or any other security
of the Parent and there is no outstanding security of any kind convertible into
or exchangeable for such capital stock. All of the issued and outstanding shares
of the capital stock of the Parent are duly authorized and are validly issued,
fully paid, nonassessable and free of any preemptive rights. When issued in
accordance with the terms of this Agreement, the Parent Shares


                                       17
<PAGE>   23
to be issued pursuant to the Merger will be duly authorized, validly issued,
fully paid, nonassessable and free of any preemptive rights.

                  (b) All the issued and outstanding shares of capital stock of
the Acquisition Sub have been or, at the Closing will be, duly authorized and
validly issued, fully paid and nonassessable, will not have been issued in
violation of any preemptive rights and will be owned by the Parent.

         3.4      Subsidiaries and Other Affiliates.

                  (a) The Parent Disclosure Schedule sets forth all of the
Subsidiaries and the jurisdiction in which each is incorporated or organized.
All issued and outstanding shares or other equity interest of each Subsidiary
are owned directly by the Parent free and clear of any charges, liens,
encumbrances, security interests or adverse claims. As used in this Agreement,
"Subsidiary" means any corporation or other legal entity of which the Parent or
any Subsidiary owns, directly or indirectly, 50% or more of the stock or other
equity interest entitled to vote for the election of directors.

                  (b) Except as set forth above, there are not as of the date
hereof, and at the Effective Time there will not be, any other shares of capital
stock or other equity interest of any Subsidiary authorized or outstanding or
any subscriptions, options, conversion or exchange rights, warrants, repurchase
or redemption agreements, or other agreements, claims or commitments of any
nature whatsoever obligating any Subsidiary to issue, transfer, deliver or sell,
or cause to be issued, transferred, delivered, sold, repurchased or redeemed,
additional shares of the capital stock or other securities or equity interests
of any Subsidiary or obligating any Subsidiary to grant, extend or enter into
any such agreement. There are no shareholder agreements, voting trusts, proxies
or other agreements, instruments or understandings with respect to the capital
stock of any Subsidiary.

                  (c) Except for the Subsidiaries and as set forth in the Parent
Financials, the Parent does not directly or indirectly own or have any
investment in any of the capital stock of, and is not a party to a partnership
or joint venture with, any other Person.

         3.5      SEC Filings; Parent Financial Statements.

                  (a) Parent has filed all forms, reports and documents required
to be filed with the U.S. Securities and Exchange Commission (the "SEC") since
April 1, 1998 on a timely basis, and has made available to the Company such
forms, reports and documents in the form filed with the SEC. All such required
forms, reports and documents (including those that the Parent may file after the
date hereof until the Closing) are referred to herein as the "Parent SEC
Reports." As of their respective dates, the Parent SEC Reports (i) were prepared
in compliance in all material respects with the requirements of the Securities
Act of 1933, as amended (the "Securities Act"), or the Securities Exchange Act
of 1934, as amended (the "Exchange Act"), as the case may be, and the rules and
regulations of the SEC thereunder applicable to such Parent SEC Reports, and
(ii) did not at the time they were filed (or if amended or superseded by a
filing prior to the date of this Agreement, then on the date of such filing)
contain any untrue statement of a material fact or omit to state a material fact
required to be stated therein or necessary in order to make the statements


                                       18
<PAGE>   24
therein, in the light of the circumstances under which they were made, not
misleading. None of the Subsidiaries is required to file any forms, reports, or
other documents with the SEC.

                  (b) Each of the consolidated financial statements (including,
in each case, any related notes thereto) contained in the Parent SEC Reports
(the "Parent Financials"), including any Parent SEC Reports filed after the date
hereof until the Closing, (i) complied or will comply as to form in all material
respects with the published rules and regulations of the SEC with respect
thereto, (ii) was or will be prepared in accordance with GAAP applied on a
consistent basis throughout the periods involved (except as may be indicated in
the notes thereto or, in the case of unaudited interim financial statements, as
may be permitted by the SEC on Form 10-Q under the Exchange Act) and (iii)
fairly presented or will fairly present, in all material respects, the
consolidated financial position of the Parent and its Subsidiaries as at the
respective dates thereof and the consolidated results of its operations and cash
flows for the periods indicated, except that the unaudited interim financial
statements were or are subject to normal and recurring year-end adjustments
which were not, or are not expected to be, material in amount. The balance sheet
of the Parent contained in the Parent SEC Reports as of September 30,1998 is
hereinafter referred to as the "Parent Balance Sheet." Except as disclosed in
the Parent Financials or in the Parent Disclosure Schedule, neither the Parent
nor any of its Subsidiaries has any liabilities (absolute, accrued, contingent
or otherwise) of a nature required to be disclosed on a balance sheet or in the
related notes to the consolidated financial statements prepared in accordance
with GAAP that are, individually or in the aggregate, material to the Business
of Parent, except liabilities (i) provided for in the Parent Balance Sheet, (ii)
incurred since the date of the Parent Balance Sheet in the ordinary course of
business consistent with past practices, or (iii) incurred in connection with
the transactions contemplated hereby.

         3.6      Tax Matters.

                  (a) The Parent and its Subsidiaries have filed all Tax reports
and returns required to be filed by them and have paid or will timely pay all
Taxes and other charges shown as due on such reports and returns. All positions
taken in such Tax reports and returns that could give rise to a substantial
understatement penalty within the meaning of Section 6662 of the Code have been
disclosed therein. Neither the Parent nor any of its Subsidiaries is delinquent
in the payment of any material Tax assessment or other governmental charge
(including without limitation applicable withholding taxes). Any provision for
Taxes reflected in the Parent Financials is adequate for payment of any and all
Tax liabilities for periods ending on or before September 30, 1998 and there are
no Tax liens on any assets of the Parent or its Subsidiaries except liens for
current Taxes not yet due.

                  (b) There has not been any audit of any Tax return filed by
the Parent or any of its Subsidiaries and no audit of any such Tax return is in
progress and neither the Parent nor any Subsidiary has been notified by any Tax
authority that any such audit is contemplated or pending. The Parent knows of no
Tax deficiency or claim for additional Taxes asserted or threatened to be
asserted against the Parent or any of its Subsidiaries by any Taxing authority
and the Parent knows of no grounds for any such assessment. No extension of time
with respect to any date on which a Tax return was or is to be filed by the
Parent or any of its Subsidiaries is in force, and no waiver or


                                       19
<PAGE>   25
agreement by the Parent or any of its Subsidiaries is in force for the extension
of time for the assessment or payment of any Tax.

         3.7      No Material Adverse Change. Since September 30, 1998, except
as described in the Parent Financials, there has not been any material adverse
change in the Business of Parent.

         3.8      Compliance with Laws.

                  (a) The Parent and its Subsidiaries have all Permits material
to the conduct of their respective businesses, such Permits are in full force
and effect, and no proceeding is pending or, to the best knowledge of the
Parent, threatened to revoke or limit any Permit.

                  (b) The Parent and its Subsidiaries are not in violation of
any applicable law, ordinance or regulation or any order, judgment, injunction,
decree or other requirement of any court, arbitrator or governmental or
regulatory body, except for violations that would not, in the aggregate, have a
material adverse effect on the Business of Parent. Since its incorporation, the
Parent has not received notice of, and there has not been any citation, fine or
penalty imposed against the Parent or any of its Subsidiaries for, any such
violation or alleged violation.

         3.9      No Breach. Except for the filing of the Merger Certificate
with the Secretary of State of Delaware, the execution, delivery and performance
of this Agreement by the Parent and the Acquisition Sub and the consummation by
the Parent and the Acquisition Sub of the transactions contemplated hereby will
not (i) violate any provision of the Certificate of Incorporation or Bylaws of
the Parent or the Acquisition Sub, (ii) violate, conflict with or result in the
breach of any of the terms or conditions of, result in modification of the
effect of, or otherwise give any other contracting party the right to terminate,
or constitute (or with notice or lapse of time or both constitute) a default
under, any instrument, contract or other agreement to which the Parent or any of
its Subsidiaries, including the Acquisition Sub, is a party or to which any of
them or any of their assets or properties is bound or subject; (iii) violate any
law, ordinance or regulation or any order, judgment, injunction, decree or other
requirement of any court, arbitrator or governmental or regulatory body
applicable to the Parent or its Subsidiaries or by which any of the Parent's or
its Subsidiaries' assets, properties or securities is bound; (iv) violate any
Permit; (v) require any filing with, notice to, or permit, consent or approval
of, any other governmental or regulatory body; or (vi) result in the creation of
any lien or other encumbrance on the assets, properties or securities of the
Parent or its Subsidiaries, excluding from the foregoing clauses (ii), (iii),
(iv), (v) and (vi) any exceptions to the foregoing that, in the aggregate, would
not have a material adverse effect on the Business of Parent or on the ability
of the Parent or the Acquisition Sub to consummate the transactions contemplated
hereby.

         3.10     Actions and Proceedings. There are no outstanding orders,
awards, judgments, injunctions, decrees or other requirements of any court,
arbitrator or governmental or regulatory body against the Parent or any
Subsidiary, including the Acquisition Sub, or any of their securities, assets or
properties. There are no actions, suits, investigations or claims or legal,
administrative or arbitration proceedings pending or, to the best knowledge of
the Parent, threatened against the Parent or any Subsidiary, including the
Acquisition Sub, that individually or in the aggregate would have a material
adverse effect upon the transactions contemplated hereby or the Business of
Parent.


                                       20
<PAGE>   26
To the best knowledge of the Parent, there is no fact, event or circumstance now
in existence that reasonably could be expected to give rise to any action, suit,
claim, proceeding or investigation that individually or in the aggregate would
have a material adverse effect upon the transactions contemplated hereby or on
the Business of Parent.

         3.11     Contracts and Other Agreements. The Parent's SEC Filings set
forth the material contracts of the Parent and Subsidiaries except for those
contracts listed in the Parent Disclosure Schedule which are no longer material
contracts of the Parent or its Subsidiaries. Each such contract is valid,
subsisting, in full force and effect, binding upon the Parent or Subsidiary, as
the case may be, and to the best knowledge of the Parent, binding upon the other
parties thereto in accordance with their terms (subject to the application of
general principles of equity or by the effect of bankruptcy, insolvency,
reorganization, moratorium or similar laws generally affecting creditors'
rights), and the Parent and its Subsidiaries are not in default under any of
them, nor, to the best knowledge of the Parent is any other party to any such
contract or other agreement in default thereunder, nor does any condition exist
that with notice or lapse of time or both would constitute a default thereunder,
except, in each case, such defaults as would not, individually or in the
aggregate, have a material adverse effect on the Business of Parent.

         3.12     Intellectual Property. The Parent and its Subsidiaries own, or
are licensed to use, or otherwise have the right to use all patents, trademarks,
service marks, trade names, logos, franchises and copyrights, and all
applications for any of the foregoing, and all technology, inventions, trade
secrets, know-how, computer software and processes used in or necessary for the
conduct of their respective businesses as now conducted or proposed to be
conducted (collectively, the "Parent Proprietary Rights"). The Parent is not
aware of any claim by any third party that the business of the Parent or its
Subsidiaries as currently conducted or proposed to be conducted infringes upon
the valid proprietary rights of others, nor has the Parent or its Subsidiaries
received any notice or claim from any third party of such infringement by the
Parent or any of its Subsidiaries, except, in one case, the Parent has received
a letter from the owner of a patent asking the Parent to compare the Parent's
Medisorb technology disclosed in a published international patent application
with such owner's patented technology. The Parent is not aware of any
infringement by any third party on, or any competing claim of right to use or
own any of, the Parent Proprietary Rights that could have a material adverse
effect on the Business of Parent. The Parent and its Subsidiaries have the right
to use, free and clear of claims or rights of others, all customer lists and
computer software used in the conduct of their respective businesses. To the
best knowledge of the Parent, none of the activities of the employees of the
Parent on behalf of the Parent violates any agreements or arrangements which any
such employees have with former employers.

         3.13     Brokerage. Except as otherwise disclosed to the Company, no
broker, finder, agent or similar intermediary has acted on behalf of the Parent
in connection with this Agreement or the transactions contemplated hereby, and
there are no brokerage commissions, finders' fees or similar fees or commissions
payable in connection herewith based on any agreement, arrangement or
understanding with the Parent or the Acquisition Sub.


                                       21
<PAGE>   27
         3.14     Environmental Matters. The Parent has all environmental
permits required to conduct its business as currently conducted. There is no
environmental or health and safety matter that could have a material adverse
effect on the Business of Parent.

         3.15     Millennium Plan. The Parent has a Millennium Plan that has
been approved by the Board of Directors of the Parent. The Parent is in
compliance with such Millennium Plan. The Parent expects to be Year 2000
Compliant prior to the advent of the year 2000, without considering the
inclusion of the Company as a subsidiary of the Parent.

         3.16     Disclosure. The representations and warranties and statements
of the Parent and the Acquisition Sub contained in this Agreement (including in
the Parent Disclosure Schedule) do not contain, and will not contain at the
Closing Date, any untrue statement of a material fact, and do not omit, and will
not omit at the Closing Date, to state any material fact necessary to make such
representations, warranties and statements, in light of the circumstances under
which they are made, not misleading. There is no fact known to the Parent that
has not been disclosed to the Company in this Agreement (including in the Parent
SEC Filings or the Parent Disclosure Schedule) that is reasonably likely to have
a material adverse effect on the Business of Parent.


                                    SECTION 4
                            COVENANTS AND AGREEMENTS

         The parties covenant and agree as follows:

         4.1      Conduct of Business. Except with the prior written consent of
the other party, which will not be unreasonably withheld, and except as
otherwise contemplated herein, during the period from the date hereof to the
Closing Date, the Company, on the one hand and the Parent and its Subsidiaries,
on the other hand shall:

                  (a) Preservation of the Business; Maintenance of Properties,
Contracts. Use all reasonable efforts to preserve its business, advertise,
promote and market its services, keep its properties intact, preserve its
goodwill and maintain all physical properties in good operating condition;

                  (b) Intellectual Property Rights. Use all reasonable efforts
to preserve and protect its Proprietary Rights; and

                  (c) Ordinary Course of Business. Operate its business
diligently and in the ordinary course.

         4.2      Covenants of the Company Pending Closing.

                  (a) Except with the prior written consent of the Parent, which
will not be unreasonably withheld, and except as otherwise contemplated or
disclosed herein, during the period from the date hereof to the Closing Date,
the Company shall:


                                       22
<PAGE>   28
                           (i) Preservation of Personnel. Use all reasonable
efforts to preserve intact its business organization and keep available the
services of its present employees, in accordance with past practice, it being
understood that termination of employees with poor performance ratings shall not
constitute a violation of this covenant;

                           (ii) Insurance. Use all reasonable efforts to keep in
effect casualty, public liability, workers' compensation and other insurance
policies in coverage amounts not less than those in effect at the date of this
Agreement; and

                           (iii) Ordinary Course of Business. Operate its
business diligently and solely in the ordinary course.

                  (b) Except with the prior written consent of the Parent,
except as otherwise contemplated or disclosed herein, during the period from the
date hereof to the Closing Date, the Company shall not:

                           (i) Disposition of Assets. Sell or transfer, or
mortgage, pledge or create or permit to be created any lien on, any of its
assets, other than sales or transfers in the ordinary course of business and
liens existing under arrangements disclosed in the Company Disclosure Schedule;

                           (ii) Liabilities. (A) Incur any obligation or
liability other than in the ordinary course of the Company's business, (B) incur
any indebtedness for borrowed money or (C) enter into any contracts or
commitments involving payments by the Company of $25,000 or more, other than
purchase orders or commitments for inventory materials and supplies in the
ordinary course of business;

                           (iii) Compensation. (A) Change the compensation or
fringe benefits of any officer, director, employee or consultant, except for
ordinary merit increases for employees, or (B) enter into or modify any Plan or
any employment, severance or other agreement with any officer, director,
employee or consultant of the Company;

                           (iv) Capital Stock. (A) Grant any option (other than
options exercisable for an aggregate of shares of Company Common Stock granted
to employees or consultants who are hired after the date hereof as part of the
standard compensation for such employees or consultants), warrant or other right
to purchase, or to convert any obligation into, shares of its capital stock, (B)
declare or pay any dividend or other distribution with respect to any shares of
its capital stock or (C) issue any shares of its capital stock, except upon the
exercise of options and warrants or the conversion of Preferred Stock
outstanding on the date hereof;

                           (v) Charter and Bylaws. Amend the Certificate of
Incorporation or Bylaws of the Company;

                           (vi) Acquisition. Make any material acquisition of
property other than in the ordinary course of the Company's business; or


                                       23
<PAGE>   29
                           (vii) License Agreements. Enter into or modify any
license, technology development or technology transfer agreement with any other
Person.

         4.3      Corporate Examinations and Investigations. Prior to the
Effective Time, each of the Parent and the Company shall be entitled, at its own
expense, through its respective employees and representatives, to have such
access to the assets, properties, business, books, records and operations of the
other party as the Parent and the Company shall reasonably request in connection
with such party's investigation of the other party with respect to the
transaction contemplated hereby. Any such investigation and examination shall be
conducted at reasonable times and the party being investigated shall cooperate
fully therein. In order that the party conducting such investigation may have
full opportunity to make such investigation, the party being investigated shall
furnish the representatives of the party conducting such investigation during
such period with all such information and copies of such documents concerning
the affairs of the party being investigated as such representatives may
reasonably request and cause its officers, employees, consultants, agents,
accountants and attorneys to cooperate fully with such representatives in
connection with such investigation.

         4.4      Expenses. Whether or not the Merger is consummated, each party
shall bear its own expenses incurred in connection with the preparation,
execution and performance of this Agreement and the transactions contemplated
hereby, including without limitation, all fees and expenses of agents,
representatives, brokers, investment bankers, financial advisors, counsel and
accountants. The expenses of the Company with respect to its agents,
representatives, brokers, investment bankers, financial advisors, counsel and
accountants shall not be in excess of $350,000. No expenses required to be borne
by the Company, the Parent or the Surviving Corporation, including, without
limitation, fees, commissions and expenses payable to the Company's investment
banker and financial advisor, shall reduce the amount of the Merger
Consideration payable to the Participating Holders.

         4.5      Authorization from Others. Prior to the Closing Date, the
parties shall use all reasonable efforts to obtain all authorizations, consents
and permits required to permit the consummation of the transactions contemplated
by this Agreement.

         4.6      Consummation of Agreement. Each party shall use all reasonable
efforts to perform and fulfill all conditions and obligations to be performed
and fulfilled by it under this Agreement and to ensure that to the extent within
its control or capable of influence by it, no breach of any of the respective
representations, warranties and agreements hereunder occurs or exists on or
prior to the Effective Time, all to the end that the transactions contemplated
by this Agreement shall be fully carried out in a timely fashion.

         4.7      Further Assurances. Each of the parties shall execute such
documents, further instruments of transfer and assignment and other papers and
take such further actions as may be reasonably required or desirable to carry
out the provisions hereof and the transactions contemplated hereby.

         4.8      Registration of Parent Shares. The Parent shall provide the
Registration Rights set forth in the Agreement with the Company's Stockholders
set forth on Exhibit C attached hereto.


                                       24

<PAGE>   30
         4.9 Public Announcements and Confidentiality. Any press release or
release of other information to the press with respect to this Agreement or the
transactions contemplated hereby shall be mutually approved by the Parent and
the Company. Any future press release by the Parent or the Surviving Corporation
making reference to or containing the name of David A. Edwards or Robert S.
Langer shall require the prior approval of Dr. Edwards and Dr. Langer, as
appropriate, which shall not be unreasonably withheld. The disclosure of
confidential or proprietary information by the Parent or the Company to the
other shall be governed by the terms and conditions of the Confidential
Disclosure Agreement between the Parent and the Company dated November 4, 1998.

         4.10 No Solicitation. From and after the date of this Agreement until
the first to occur of the Effective Time or the termination of this Agreement,
the Company will not (i) solicit, initiate or knowingly encourage discussions
with any Person, other than the Parent, relating to the possible merger or
consolidation of the Company with or into another Person or acquisition of any
of the assets or capital stock of the Company (an "Acquisition Transaction") or
(ii) participate in any negotiations regarding, or furnish to any other Person
information with respect to, any effort or attempt by any other Person to do or
to seek any Acquisition Transaction. The Company agrees to inform the Parent in
reasonable detail within three business days of receipt by the Company of any
offer, proposal or inquiry relating to any Acquisition Transaction.

         4.11     Intentionally Omitted.

         4.12 Parent SEC Filings. Prior to the Effective Time, the Parent shall
furnish the Company with a copy of each periodic or current report filed by it
under the Exchange Act promptly after filing the same. All filings made by the
Parent after the date hereof pursuant to the Exchange Act will be made in a
timely fashion, will comply as to form in all material respects with the
applicable provisions of the Exchange Act and the rules and regulations
thereunder and will not contain any untrue statement of a material fact or omit
to state a material fact required to be stated therein or necessary to make the
statements therein, in light of the circumstances under which they are made, not
misleading.

         4.13     Employee Benefits Matters.

                  (a) The Surviving Corporation shall continue the employment of
each employee of the Company who was employed on the date before the Effective
Time at the same wage and salary level in effect on the day before the Effective
Time on an "at will" basis. Following the Effective Time, the Surviving
Corporation shall provide to the employees of the Surviving Corporation, who
formerly were employees of the Company, employee benefits, including but not
limited to participation in and benefits under 401(k) plans, equity incentive
plans, stock ownership and purchase plans, group life plans, accidental death
and dismemberment plans, medical and hospitalization plans and long term
disability plans, substantially the same as those provided to similarly situated
employees of the Parent. From and after the Effective Time, employees of the
Surviving Corporation who were employees of the Company on the day before the
Effective Time shall receive full credit for all purposes under such plans,
including without limitation for purposes of determining eligibility and vesting
levels, but not for the actual accrual of benefits, for their service with the
Company prior to the Effective Time, and all preexisting conditions, limitations
and waiting periods to which any such employees are subject shall be waived
under the welfare plans of 



                                       25
<PAGE>   31
the Parent. Nothing in this section or elsewhere in this Agreement will preclude
the Parent from amending or terminating in its discretion any employee benefit
plan maintained by the Parent.

                  (b) The provisions of this Section 4.13 respecting the
Parent's and the Surviving Corporation's agreements to grant service credits as
provided in Section 4.13(a) are intended to be for the benefit of and
enforceable by the persons referred to therein or the parties to these
agreements, respectively, and their heirs and representatives.

                  (c) Except as otherwise provided in this Agreement, all
personnel policies and procedures of the Company will be discontinued as of the
Effective Time and employees of the Company will become covered as of the
Effective Time under the human resources policies and procedures of the Parent.
For all purposes of applying the human resources policies and procedures of the
Parent, the employees of the Company will be credited for their service as
employees of the Company prior to the Effective Time.

         4.14 Conduct of the Surviving Corporation. The President and Chief
Scientific Officer of the Surviving Corporation will report to the senior
management of the Parent.

         4.15     Indemnification of Directors and Officers.
                  (a) In the event of any threatened or actual claim, action,
suit, proceeding or investigation, whether civil, criminal or administrative,
including without limitation any such claim, action, suit, proceeding or
investigation in which any person who is now, or has been at any time prior to
the date of this Agreement, or who become prior to the Effective Time, a
director or officer of the Company (the "Indemnified Parties") is, or is
threatened to be, made a party based in whole or in part on, or arising in whole
or in part out of, or pertaining to (i) the fact that he is or was a director or
officer of the Company, or (ii) this Agreement or any of the transactions
contemplated hereby, whether in any case asserted or arising before or after the
Effective Time, the parties hereto agree to cooperate and use their best efforts
to defend against and respond thereto. It is understood and agreed that after
the Effective Time, the Surviving Corporation shall indemnify and hold harmless,
as and to the fullest extent permitted by law, each such Indemnified Party
against any losses, claims, damages, liabilities, costs, expenses (including
reasonable attorney's fees and expenses in advance of the final disposition of
any claim, suit, proceeding or investigation to each Indemnified Party to the
fullest extent permitted by law upon receipt of any undertaking required by
applicable law), judgments, fines and amounts paid in settlement in connection
with any such threatened or actual claim, action, suit, proceeding or
investigation; provided, however, that the Surviving Corporation shall not
indemnify any Person with respect to any losses, claims, damages, liabilities,
costs, expenses, judgments, fines and amounts paid in settlement or otherwise in
connection with any such threatened or actual claim, action, suit, proceeding or
investigation arising out of such Person's (i) willful misconduct or
recklessness; (ii) acts which such Person knew, or should have known, were
illegal at the time such acts were committed; or (iii) acts in contravention of
such Person's duties to the Company. In the event of any threatened or actual
claim, action, suit, proceeding or investigation (whether asserted or arising
before or after the Effective Time), the Indemnified Parties may retain counsel
reasonably satisfactory to them after consultation with the Surviving
Corporation; provided, however, that (i) the Surviving Corporation shall have
the right to assume the defense thereof and upon such assumption the Surviving
Corporation shall not be liable 


                                       26
<PAGE>   32
to any Indemnified Party in connection with the defense thereof, except that if
the Surviving Corporation elects not to assume such defense or counsel for the
Indemnified Parties or reasonably advises the Indemnified Parties that there are
issues which raise conflicts of interest between the Surviving Corporation and
the Indemnified Parties, the Indemnified Parties may retain counsel reasonably
satisfactory to them after consultation with the Surviving Corporation, and the
Surviving Corporation shall pay the reasonable fees and expenses of such counsel
for the Indemnified Parties, (ii) the Surviving Corporation shall be obligated
pursuant to this paragraph to pay for only one counsel for all Indemnified
Parties, (iii) the Surviving Corporation shall not be liable for any settlement
effected without its prior written consent (which consent shall not be
unreasonably withheld) and (iv) the Surviving Corporation shall have no
obligation hereunder to any Indemnified Party when and if a court of competent
jurisdiction shall ultimately determine, and such determination shall have
become final and nonappealable, that indemnification of such Indemnified Party
in the manner contemplated hereby is prohibited by applicable law. Any
Indemnified Party wishing to claim indemnification under this Section 4.15 upon
learning of any such claim, action, suit, proceeding or investigation shall
notify the Surviving Corporation thereof, provided that the failure to so notify
shall not affect the obligations of the Surviving Corporation under this Section
4.15 except to the extent such failure to notify materially prejudices the
Surviving Corporation. The Surviving Corporation's obligations under this
Section 4.15 shall continue in full force and effect for a period of six (6)
years from the Effective Time, provided, however, that all rights to
indemnification in respect of any claim asserted or made within such period
shall continue until the final disposition of such claim.

         4.16 Notice of Developments. Each of the Company and the Parent will
give prompt written notice to the other of any material adverse development
causing a breach of any of its representations and warranties in Sections 2 and
3, respectively. No disclosure by any party pursuant to this Section 4.16,
however, shall be deemed to amend or supplement the applicable Disclosure
Schedule or to prevent or cure any misrepresentation, breach of warranty or
breach of covenant. Each waiver of any condition to Closing by either the Parent
or the Company shall be deemed a waiver of the right to consider the failure to
meet such condition on the part of the other party to be a breach of such other
party's representations and warranties.

         4.17 Tax-free Reorganization. None of the parties will knowingly take
any action that would cause the Merger to fail to qualify as a reorganization
within the meaning of Section 368(a) of the Code. Each of the parties shall
report the Merger for income tax purposes as a reorganization within the meaning
of Section 368(a) of the Code (and any comparable state or local tax statute).
The Parent and the Company each shall execute and deliver certificates, in forms
reasonably satisfactory to the counsel of both Parent and the Company, signed by
officers of Parent and Company, respectively, setting forth such factual
representations and covenants as are customary to serve as a basis for the tax
opinions required pursuant to Sections 6.12 and 7.5 of this Agreement.

         4.18 Pooling-of-Interests. The transaction contemplated hereby is
intended to be treated, for accounting purposes, as a pooling-of-interests. None
of the parties will knowingly take any action that would prevent such
transaction from being treated as a pooling-of-interests as of the date hereof
and for a period of two years hereafter.



                                       27
<PAGE>   33
         4.19 Continuation of Employment and Consulting Arrangements. The Parent
shall cause the survivor corporation to continue to (a) employ Ralph Niven and
Markus Cappel under the terms and conditions of the current employment
agreements between such individuals and the Company, (b) engage Robert S. Langer
as a consultant under the terms and conditions of the current consulting
agreement between Dr. Langer and the Company.


                                    SECTION 5
CONDITIONS PRECEDENT TO THE OBLIGATIONS OF EACH PARTY TO CONSUMMATE THE MERGER

         The respective obligations of each party to consummate the Merger shall
be subject to the satisfaction or waiver, at or before the Effective Time, of
each of the following conditions:

         5.1 Approvals. All required approvals of the stockholders of the
Company and all consents, approvals and filings referred to in Sections 2.2,
2.10 and 3.9 of this Agreement or in the corresponding sections of each party's
Disclosure Schedule shall have been obtained; provided, however, that if the
Parent waives the obtaining of any consent set forth in Section 2.10 of the
Company Disclosure Schedule such consent shall not be a condition to the
Company's obligation to consummate the Merger.

         5.2 Absence of Order. No restraining order or injunction of any court
which prevents consummation of the Merger shall be in effect.


                                    SECTION 6
     CONDITIONS PRECEDENT TO THE OBLIGATIONS OF PARENT AND THE ACQUISITION
                          SUB TO CONSUMMATE THE MERGER

         The obligation of the Parent and the Acquisition Sub to consummate the
Merger is subject to the satisfaction or waiver by the Parent, at or before the
Effective Time, of the following conditions:

         6.1 Representations, Warranties and Covenants. The representations and
warranties of the Company contained in this Agreement shall be true and correct
in all material respects on and as of the Effective Time with the same force and
effect as though made on and as of the Effective Time (with such exceptions as
may be permitted under or contemplated by this Agreement) and there shall not
have been any material adverse change in the Business of Company since the date
hereof. The Company shall have performed and complied in all material respects
with all covenants and agreements required by this Agreement to be performed or
complied with by the Company on or prior to the Effective Time. The Company
shall have delivered to the Parent a certificate, dated the Closing Date, to the
foregoing effect, as applicable.

         6.2 Stockholder Approval. Stockholders of the Company holding at least
91% of the outstanding Company Common Stock must consent to the Merger in
writing.

         6.3      Intentionally Omitted.

                                       28
<PAGE>   34
         6.4 Opinion of Counsel to Company. The Parent shall have received an
opinion of counsel to the Company, dated the Closing Date, in form and substance
reasonably acceptable to the Parent. Such opinion must include, among other
things, an opinion that no filing under the Hart-Scott-Rodino Antitrust
Improvements Act of 1976, as amended, ("HSR Act") is required in connection with
the Merger by the Company or any stockholder of the Company.

         6.5 Merger Documents. The Company shall have executed and delivered the
Merger Certificate referred to in Section 1.2.

         6.6 Certificates. The Company shall have furnished the Parent with such
other certificates and documents and certificates of public officials as may be
reasonably requested by the Parent.

         6.7 Stockholders' Agreement. That certain Stockholders' Agreement,
dated July 31, 1997, among the Company, Polaris Venture Partners, L.P., Polaris
Venture Partners Founders' Fund, L.P., David A. Edwards, Robert S. Langer and
other holders of the Company's Common Stock, as amended, shall have been
terminated.

         6.8 Co-Sale Agreement. That certain Co-Sale Agreement, dated July 31,
1997, among the Company, Polaris Venture Partners, L.P., Polaris Venture
Partners Founders' Fund, L.P., David A. Edwards and Robert S.
Langer, as amended, shall have been terminated.

         6.9 Management Rights Letter Agreements. Those certain Management
Rights Letter Agreements, dated July 31, 1997, April 6, 1998 and June 29, 1998,
among the Company, Polaris Venture Partners, L.P. and Polaris Venture Partners
Founders' Fund, L.P. shall have been terminated.

         6.10 Investors' Rights Agreement. That certain Amended and Restated
Investors' Rights Agreement, dated November 25, 1998, among the Company, David
A. Edwards, Robert S. Langer and investors executing such agreement shall have
been terminated, including without limitations, termination of the rights set
forth in Sections 3 and 6 thereof.

         6.11 New Agreement. The Company and the Company's stockholders shall
have entered into the Amendments to the Restricted Stock Agreements, Escrow
Agreements and Agreement with Stockholders, as applicable, with the Parent.

         6.12 Tax Opinion. Parent shall have received an opinion of its counsel,
dated the Closing Date, substantially to the effect that, on the basis of the
facts and representations set forth in such opinion, or set forth elsewhere and
referred to therein, for federal income tax purposes the Merger will constitute
a reorganization within the meaning of Section 368(a) of the Code.

         6.13 Patent Opinion. Parent shall have received an opinion of Arnall
Golden & Gregory dated the Closing Date, in form and substance reasonably
acceptable to Parent.

         6.14 Accounting Treatment. The Parent shall have received a letter
dated the Closing Date from Deloitte & Touche LLP addressed to Parent stating
that, as of the Closing Date, no 



                                       29
<PAGE>   35
conditions exist that would preclude the Parent's accounting for the Merger with
the Company as a pooling-of-interests and a copy of a letter dated the Closing
Date from PricewaterhouseCoopers LLP addressed to the Company to the effect that
no conditions exist that would preclude the Company from being a party to a
business combination for which the pooling-of-interests method of accounting
would be available.


                                    SECTION 7
 CONDITIONS PRECEDENT TO THE OBLIGATION OF THE COMPANY TO CONSUMMATE THE MERGER

         The obligation of the Company to consummate the Merger is subject to
the satisfaction or waiver by the Company at or before the Effective Time, of
the following conditions:

         7.1 Representations, Warranties and Covenants. The representations and
warranties of the Parent and the Acquisition Sub contained in this Agreement
shall be true and correct in all material respects on and as of the Effective
Time with the same force and effect as though made on and as of the Effective
Time (with such exceptions as may be permitted under or contemplated by this
Agreement). Both the Parent and the Acquisition Sub shall have performed and
complied in all material respects with all covenants and agreements required by
this Agreement to be performed or complied with by then on or prior to the
Effective Time. Both the Parent and the Acquisition Sub shall have delivered to
the Company a certificate, dated the Effective Time, to the foregoing effect.

         7.2 Opinion of Counsel to Parent. The Company shall have received an
opinion of counsel to the Parent and the Acquisition Sub, dated the Closing
Date, in form and substance reasonably acceptable to the Company.

         7.3 Certificates. The Parent shall have furnished the Company with such
certificates of public officials as may be reasonably requested by the Company.

         7.4 Employment and Consulting Agreements. The Surviving Corporation
shall have entered into an Executive Employment and Consulting Agreement with
David A. Edwards, the President and Chief Scientific Officer of the Surviving
Corporation, in a form mutually acceptable to the parties thereto. The Surviving
Corporation shall have entered into Employment Agreements with Jean Balch,
Richard Batycky, Jeffrey Hrkach, and Lloyd Johnston.

         7.5 Tax Opinion. The Company shall have received an opinion of its
counsel, dated the Closing Date, substantially to the effect that, on the basis
of the facts and representations set forth in such opinion, or set forth
elsewhere and referred to therein, for federal income tax purposes the Merger
will constitute a reorganization within the meaning of Section 368(a) of the
Code.

                                    SECTION 8
                        TERMINATION, AMENDMENT AND WAIVER

         8.1 Termination. This Agreement may be terminated at any time prior to
the Effective Time, as follows:




                                       30
<PAGE>   36
                  (a) by the Company or the Parent if, without fault of the
terminating party, the Effective Time shall not have occurred on or before
February 1, 1999, which date may be extended by mutual consent of the parties;

                  (b) by the Board of Directors of the Company upon written
notice to the Parent if the Parent or the Acquisition Sub has materially
breached any representation, warranty, covenant or agreement contained herein
and has not cured such breach within ten (10) business days of receipt of
written notice from the Company or by the Closing Date, if earlier;

                  (c) by the Parent upon written notice to the Company if the
Company has materially breached any representation, warranty, covenant or
agreement contained herein and has not cured such breach within ten (10)
business days of receipt of written notice from the Parent or by the Closing
Date, if earlier;

                  (d) by any party if any court of competent jurisdiction or
governmental body shall have issued an order, decree or ruling or taken any
other action restraining, enjoining or otherwise prohibiting the Merger and such
order, decree or ruling shall have become final and nonappealable;

                  (e) by either the Parent or the Company if the requisite
stockholder vote approving the Merger is not obtained; or

                  (f) at any time with the mutual written consent of the Parent
and the Company.

         8.2 Effect of Termination. If this Agreement is terminated as provided
in Section 8.1, this Agreement shall forthwith become void and have no effect,
without liability on the part of any party, its directors, officers or
stockholders, other than the provisions of this Section 8.2, Section 4.4
relating to expenses and Section 4.9 relating to publicity and confidentiality
to the extent provided therein. Nothing contained in this Section 8.2 shall
relieve any party from liability for any breach of this Agreement occurring
before such termination.

         8.3 Amendment. This Agreement may not be amended except by an
instrument signed by each party hereto; provided, however, that after adoption
of this Agreement by the stockholders of the Company, without the further
approval of the stockholders of the Company, no amendment may be made that (a)
alters or changes the amount or kind of consideration to be received as provided
herein or (b) alters or changes any of the terms of this Agreement if such
alteration or change would materially adversely affect the stockholders of the
Company.

         8.4 Waiver. At any time prior to the Effective Time, any party hereto
may, (a) extend the time for the performance of any of the obligations or other
acts of any other party hereto or (b) waive compliance with any of the
agreements of any other party or any conditions to its own obligations, in each
case only to the extent such obligations, agreements and conditions are intended
for its benefit; provided that any such extension or waiver shall be binding
upon a party only if such extension or waiver is set forth in a writing executed
by such party.

                                       31
<PAGE>   37
                                    SECTION 9
                                 INDEMNIFICATION

         9.1 Survival. Notwithstanding any right of any party to fully
investigate the affairs of the other party and notwithstanding any knowledge of
facts determined or determinable by such party pursuant to such investigation or
right of investigation, each party has the right to rely fully upon the
representations, warranties, covenants and agreements of each other party in
this Agreement or in any certificate, financial statement or other document
delivered by any party pursuant hereto. Notwithstanding the foregoing, if on the
Closing Date a party has actual, conscious knowledge that any representation or
warranty made by any other party under this Agreement is false in any material
respect and fails to disclose such knowledge to such party on or before the
Closing Date, then, unless such party is also in possession of such knowledge on
or before the Closing Date, the first party shall be deemed to have waived any
breach arising out of such representation or warranty being false in a material
respect as of the Closing Date. All such representations, warranties, covenants
and agreements shall survive the execution and delivery hereof and the Closing
hereunder, subject to the limitations set forth in Section 4 of the Agreement
with the Company's Stockholders. No Person shall have a right to recovery
against any party (or any officer, director, employee or agent of a party) other
than through the exercise of the indemnification rights set forth in Section 4
of the Agreement with the Company's Stockholders, which shall constitute the
sole and exclusive remedy after the Closing Date for any breach by a party of
any representation, warranty or covenant contained herein or in any certificate
or other instrument delivered pursuant hereto.

         9.2 Indemnification. The Company and the Participating Holders shall
provide the indemnification rights set forth in the Agreement with the Company's
Stockholders set forth in Exhibit C attached hereto (the "Agreement with
Company's Stockholders").


                                   SECTION 10
                            GLOSSARY OF DEFINED TERMS

         10.1 Glossary. The capitalized terms used herein have the following
meanings:

"Acquisition Sub" means Alkermes Acquisition Sub, Inc., a Delaware corporation.

"Acquisition Transaction" has the meaning set forth in Section 4.10.

"Agreement" means this Agreement and Plan of Merger among the Parent, the
Acquisition Sub, and the Company.

"Agreement with the Company's Stockholders" has the meaning set forth in Section
9.2.

"Business of Company" has the meaning set forth in Section 2.1(a).

"Business of Parent" has the meaning set forth in Section 3.1(a).

"Closing" has the meaning set forth in Section 1.2.

                                       32
<PAGE>   38
"Closing Date" means the date on which the Closing occurs.

"Closing Market Value" has the meaning set forth in Section 1.6(a)(ii).

"Code" means the Internal Revenue Code of 1986, as amended.

"Company" means the Advanced Inhalation Research, Inc., a Delaware corporation.

"Company Common Stock" has the meaning set forth in Section 1.6(a)(iii).

"Company Disclosure Schedule" has the meaning set forth in Section 2.

"Company Preferred Stock" has the meaning set forth in Section 2.3(a).

"DGCL" means General Corporation Law of the State of Delaware.

"Dissenting Shares" has the meaning set forth in Section 1.6(a)(iv).

"Effective Time" has the meaning set forth in Section 1.2.

"ERISA" means the Employee Retirement Income Security Act of 1974, as amended.

"Exchange Act" means the Securities Exchange Act of 1934, as amended.

"Exchange Agent" has the meaning set forth in Section 1.9.

"Financial Statements" has the meaning set forth in Section 2.5.

"FTC" means the Federal Trade Commission.

"Hazardous Materials" has the meaning set forth in Section 2.21.

"HSR Act" has the meaning set forth in Section 6.4.

"Merger" has the meaning set forth in the preamble.

"Merger Certificate" has the meaning set forth in Section 1.2.

"Merger Consideration" has the meaning set forth in Section 1.6(a)(vii).

"Multiemployer Plan" has the meaning set forth in Section 2.16.

"Parent" means Alkermes, Inc., a Pennsylvania corporation.

"Parent Balance Sheet" has the meaning set forth in Section 3.5(b).

"Parent Common Stock" has the meaning set forth in Section 1.6(i)(a).

"Parent Disclosure Schedule" has the meaning set forth in Section 3.

                                       33
<PAGE>   39
"Parent Financials" has the meaning set forth in Section 3.5(b).

"Parent Preferred Stock" has the meaning set forth in Section 3.3(a).

"Parent Proprietary Rights" has the meaning set forth in Section 3.12.

"Parent SEC Reports" has the meaning set forth in Section 3.5(a).

"Parent Shares" has the meaning set forth in Section 1.6(a)(i).

"Participating Holders" has the meaning set forth in Section 1.6(a)(vi).

"Participating Shares" has the meaning set forth in Section 1.6(a)(v).

"Permits" has the meaning set forth in Section 2.9(a).

"Person" means a natural person, corporation, association, trust (including a
business trust), partnership, limited liability company, joint stock company,
organization or proprietorship.

"Plans" has the meaning set forth in Section 2.16.

"Proprietary Rights" has the meaning set forth in Section 2.15.

"Qualified Plans" has the meaning set forth in Section 2.16.

"Restricted Stock" has the meaning set forth in Section 1.6(b)(i).

"SEC" means the U.S. Securities and Exchange Commission.

"Securities Act" means the Securities Act of 1933, as amended.

"Subsidiary" has the meaning set forth in Section 3.4(a).

"System" has the meaning set forth in Section 2.22.

"Surviving Corporation" has the meaning set forth in Section 1.1.

"Tax" has the meaning set forth in Section 2.8(b).

"Year 2000 Complaint" has the meaning set forth in Section 2.22.


                                   SECTION 11
                                  MISCELLANEOUS

         11.1 Notices. Any notice or other communication required or permitted
hereunder shall be in writing and shall be deemed given when so delivered in
person, by overnight courier, by facsimile transmission (with receipt confirmed
by telephone or by automatic transmission report) or 


                                       34
<PAGE>   40
two business days after being sent by registered or certified mail (postage
prepaid, return receipt requested), as follows:

                         (i)      if to the Parent or Acquisition Sub, to:

                                  Alkermes, Inc.
                                  64 Sidney Street
                                  Cambridge, MA  02139
                                  Attn:  Chief Financial Officer
                                  Facsimile:  (617) 494-9255

                                  with a copy to:

                                  Ballard Spahr Andrews & Ingersoll, LLP
                                  1735 Market Street, 51st Floor
                                  Philadelphia, PA 19103
                                  Attn: Morris Cheston, Jr., Esquire
                                  Facsimile: (215) 864-8999

                         (ii)     if to the Company, to:

                                  Advanced Inhalation Research, Inc.
                                  840 Memorial Drive
                                  Cambridge, MA  02139
                                  Attn:  President
                                  Facsimile:  (617) 354-6444

                           with a copy to:

                                  Palmer & Dodge LLP
                                  One Beacon Street
                                  Boston, MA  02108
                                  Attn:  Michael Lytton, Esquire
                                  Facsimile: (617) 227-4420

Any party may by notice given in accordance with this Section 10.1 to the other
parties designate another address or person for receipt of notices hereunder.

         11.2 Entire Agreement. This Agreement contains the entire agreement
among the parties with respect to the Merger and related transactions, and
supersedes all prior agreements, written or oral, with respect thereto except
for the Confidential Disclosure Agreement dated November 4, 1998 among the
parties.

         11.3 Governing Law. This Agreement is governed by the laws of the State
of Delaware without regard to its conflict of law provisions.

                                       35
<PAGE>   41
         11.4 Binding Effect; No Assignment. This Agreement shall be binding
upon and inure to the benefit of the parties and their respective successors and
permitted assigns. This Agreement is not assignable without the prior written
consent of the other parties hereto.

         11.5 Variations in Pronouns. All pronouns and any variations thereof
refer to the masculine, feminine or neuter, singular or plural, as the context
may require.

         11.6 Counterparts. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, and all of which
together shall constitute one and the same instrument.

         11.7 Disclosure Schedules. The Disclosure Schedules are a part of this
Agreement as if fully set forth herein.



                                       36

<PAGE>   1
                                                                     Exhibit 4.1

                   AGREEMENT WITH THE COMPANY'S STOCKHOLDERS


         Agreement dated as of _______ __, ____ among Alkermes, Inc. (the
"Parent"), a Pennsylvania corporation, Advanced Inhalation Research, Inc. (the
"Company"), a Delaware corporation, and the stockholders (the "Company
Stockholders") of the Company. Each of the Company Stockholders, the Company and
the Parent is referred to herein as a "Party" and collectively as the "Parties."

         The Parent and the Company, along with Alkermes Acquistion Sub, Inc.
(the "Acquisition Sub"), a Delaware corporation and a newly-formed, wholly owned
subsidiary of the Parent, are entering into an Agreement and Plan of Merger
concurrently herewith (the "Merger Agreement"). Capitalized terms used herein
without definition are used herein as defined in the Merger Agreement.

         The Merger Agreement contemplates a transaction in which the
Acquisition Sub shall be merged with and into the Company, the Company
Stockholders (except those exercising their appraisal rights) shall receive
Parent Common Stock as the Merger Consideration and all of the Company Common
Stock shall be canceled.

         The Parent, the Acquisition Sub and the Company make certain
representations, warranties and covenants in the Merger Agreement which will
survive the Closing for purposes of potential indemnification. The Parent and
the Company Stockholders wish to provide for post-Closing indemnification
against breaches of the Company's representations, warranties and covenants and
to make certain other covenants among themselves.

         The Merger Agreement requires, as a condition to the closing of the
Merger, that certain agreements among the Company and the Company Stockholders
be terminated immediately prior to the Effective Time. The Company and the
Company Stockholders, therefore, wish to terminate such agreements effective
immediately prior to the Effective Time.

         Now, therefore, in consideration of the premises and the mutual
promises herein made, intending to be legally bound, the Parties hereby agree as
follows.

          1.   Definitions.

         "Expiration Date" shall have the meaning set forth in Section 4(c).

         "Holder" has the meaning set forth in Section 5(a)(iii).

         "Losses" has the meaning set forth in Section 4(a).

         "Merger Agreement" has the meaning set forth in the preface above.

         "Party" has the meaning set forth in the preface above.

         "Registrable Securities" has the meaning set forth in Section 5(a).
<PAGE>   2
         "Requisite Company Stockholders" means the Company Stockholders holding
a majority in interest of the total number of shares of Parent Common Stock that
all of the Company Stockholders receive pursuant to the Merger Agreement.

         "Stockholders' Representatives" has the meaning set forth in Section

    2. Representations and Warranties of the Company Stockholders. Each of the 
Company Stockholders represents and warrants to the Parent that the statements
contained in this Section 2 are correct and complete as of the date of this
Agreement, and will be correct and complete on the Closing Date (as though made
then and as though the Closing Date were substituted for the date of this
Agreement throughout this Section 2) with respect to himself, herself or itself.

         (a) Organization of Certain Company Stockholders. If the Company
Stockholder is a corporation, partnership, limited liability company, limited
liability partnership or other entity, the Company Stockholder is duly
organized, validly existing and in good standing under the laws of the
jurisdiction of its incorporation or formation.

         (b) Authorization. The Company Stockholder has full power and authority
(including, if the Company Stockholder is a corporation, partnership, limited
liability company, limited liability partnership or other entity, full corporate
or partnership power and authority) to execute and deliver this Agreement and to
perform his, her or its obligations hereunder. This Agreement constitutes the
valid and legally binding obligation of the Company Stockholder, enforceable in
accordance with its terms and conditions.

         (c) Noncontravention. Neither the execution and the delivery of this
Agreement by the Company Stockholder, nor the performance by the Company
Stockholder of his, her or its obligations hereunder, will (i) violate any
constitution, statute, regulation, rule, injunction, judgment, order, decree,
ruling, charge or other restriction of any government, governmental agency or
court to which the Company Stockholder is subject (and, if the Company
Stockholder is a corporation, partnership, limited liability company, limited
liability partnership or other entity, any provision of its charter, bylaws,
partnership agreement or other governing documents), or (ii) conflict with,
result in a breach of, constitute a default under, result in the acceleration
of, create in any party the right to accelerate, terminate, modify or cancel or
require any notice under any agreement, contract, lease, license, instrument or
other arrangement to which the Company Stockholder is a party or by which he,
she or it is bound or to which any of his, her or its assets is subject.

         (d) Investment. The Company Stockholder (i) understands that the Parent
Common Stock has not been registered under the Securities Act, or under any
state securities laws and is being offered and sold in reliance upon federal and
state exemptions for transactions not involving any public offering, (ii) is
acquiring the Parent Common Stock solely for his, her or its own account for
investment purposes, and not with a view to the distribution thereof, (iii)
understands that an investment in the Parent involves substantial risks,
including loss of the entire amount of such investment, and (iv) has received
certain information concerning the Parent and has had the opportunity to obtain
additional information as desired in order to evaluate the merits and the risks
inherent in acquiring and holding the Parent Common Stock.

                                       2
<PAGE>   3

         (e) Company Shares. The Company Stockholder holds of record the number
of shares of Company Common Stock Shares set forth next to his, her or its name
on Schedule 2(e) attached hereto.

     3.  Post-Closing Covenants.  The Parties agree, as follows, with respect 
to the period following the Closing.

         (a) General. In case, at any time after the Closing, any further action
is necessary to carry out the purposes of the Merger Agreement, each of the
Parties will take such further action (including the execution and delivery of
such further instruments and documents), as any other Party reasonably may
request, all at the sole cost and expense of the requesting Party (unless the
requesting Party is entitled to indemnification therefore under Section 4 or 5
below). The Company Stockholders acknowledge and agree that from and after the
Closing Date, the Parent, by operation of law, will be entitled to possession of
all documents, books, records (including tax records), agreements, and financial
data of any sort owned by and relating to the Company.

         (b) No Sales of Parent Common Stock Pending Earnings Release. Each
Holder who is an "affiliate" (as defined in Rule 1-02 of Regulation S-X
promulgated under the Securities Act) of Parent or of the Surviving Corporation
will not sell any shares of Parent Common Stock until after the Parent announces
its consolidated results which include at least thirty (30) days of consolidated
operations of the Parent and its subsidiaries including the Surviving
Corporation via a publicly disseminated press release. The Parent will promptly
notify each such Holder of the day that it makes such announcement.

     4.  Indemnification.

         (a) Obligation of the Company Stockholders to Indemnify. Subsequent to
the Effective Time, the Company Stockholders shall, subject to the terms,
conditions and limitations set forth in Section 4(c), severally, and not
jointly, indemnify and hold harmless the Parent and the Surviving Corporation
(and their respective directors, officers, employees, agents, affiliates and
assigns) from and against all losses, liabilities, damages, deficiencies, costs
or expenses, including interest and penalties imposed or assessed by any
judicial or administrative body and reasonable attorneys' fees, whether or not
arising out of third-party claims and including all amounts paid in
investigation, defense or settlement of the foregoing pursuant to this Section 4
("Losses") based upon, arising out of or otherwise in respect of, any inaccuracy
in or breach of any representation, warranty or covenant of the Company
contained in the Merger Agreement, herein or in any certificate delivered
pursuant thereto.

          (i) The Parent shall notify the Stockholders' Representatives (as
hereinafter defined) in writing of each Loss, including a brief description of
the nature and amount thereof. In the event that the amount is unliquidated, the
Parent shall make a good faith estimate of the amount of the Loss. If, within
sixty (60) days after the submission of a Loss to the Stockholders'
Representatives the Parent has not received written notice executed by the
Stockholders' Representatives accepting and agreeing to the amount, the amount
of such Loss shall be referred to an arbitrator chosen by agreement of the
Stockholders' Representatives and the Parent. If no agreement is reached
regarding selection of the arbitrator within thirty (30) days after written
request from either Party to the other, the Parent or the Stockholders'
Representatives may submit the matter 



                                       3
<PAGE>   4
in dispute to the American Arbitration Association, to be settled by arbitration
in Boston, Massachusetts in accordance with the commercial arbitration rules of
such Association, as modified by this Section 4. The Parent and the
Stockholders' Representatives agree to act in good faith to mutually select an
arbitrator. If there is a prevailing party in such dispute, the fees and
expenses of any arbitration shall be borne by the other party; or if there is no
prevailing party, then by the Company Stockholders and the Parent in such
proportions as shall be determined by the arbitrator; or if there is no such
determination, then such fees and expenses shall be borne equally by the Company
Stockholders and the Parent. The determination of the arbitrator as to the
amount, if any, of the Loss and related expenses that is properly allowable
shall be conclusive and binding upon the parties hereto and judgment may be
entered thereon in any court having jurisdiction thereof.

         (b) Obligation of the Parent and the Acquisition Sub to Indemnify .
Subsequent to the Effective Time, both the Parent and the Acquisition Sub,
subject to the terms, conditions and limitations set forth in Section 4(c),
shall, jointly and severally, indemnify and hold harmless the Company
Stockholders (and their respective directors, officers, employees, agents,
affiliates and assigns) from and against any Losses based upon, arising out of
or otherwise in respect of, any inaccuracy in or breach of any representation,
warranty or covenant of the Parent or the Acquisition Sub contained in the
Merger Agreement, herein or in any certificate delivered pursuant hereto.

         (c) Limitations on Indemnification . Notwithstanding the foregoing, the
right to indemnification under this Section 4 shall be subject to the following
terms:

              (i) No indemnification shall be payable pursuant to Section 4(a) 
or Section 4(b) unless and until the amount of all claims for indemnification
pursuant to the applicable Section exceeds $500,000 in the aggregate, whereupon
indemnification pursuant to such Section shall be payable for all such claims
amounts, including the first $500,000 thereof; provided, however, that such
limitation shall not apply to a breach of the representation and warranty in
Section 2.20 of the Merger Agreement.

              (ii) No indemnification shall be payable pursuant to Section 4(a) 
or Section 4(b) after one hundred eighty (180) days after the Effective Time
(the "Expiration Date"), except with respect to (1) claims made prior to the
Expiration Date, (2) any breach of any representations set forth in Sections 2.8
or 3.6 of the Merger Agreement for which the Expiration Date shall be the end of
the applicable statute of limitations, and (3) all representation and warranties
with respect to Year 2000 Compliance for which the Expiration Date shall be
February 1, 2001.

              (iii) Notwithstanding any other provision of this Agreement and 
the Merger Agreement, the maximum aggregate liability of the Company
Stockholders to the Parent and the Surviving Corporation, under this Section 4
or otherwise, shall be, at any point in time, ten percent (10%) of the Aggregate
Merger Consideration Value, where the "Aggregate Merger Consideration Value"
means the value of 3.8 million shares of Parent Common Stock (as determined
based on the closing price of Parent Common Stock on the Nasdaq National Market
on the Closing Date); provided, however, this limitation shall not apply with
respect to claims made pursuant to Section 5(f) of this Agreement.

              (iv) Notwithstanding any other provision of this Agreement, the 
maximum liability of any Company Stockholder to the Parent and the Surviving
Corporation under 


                                       4
<PAGE>   5
this Section 4 or otherwise, at any point in the time is ten percent (10%) of
the product of (A) the fraction, the numerator of which is the number of shares
of the Company Common Stock held by such Company Stockholder at the Effective
Time and the denominator of which is the number of total outstanding shares of
Company Common Stock at the Effective Time and (B) the Aggregate Merger
Consideration Value; provided, however, this limitation shall not apply with
respect to claims made pursuant to Section 5(f) of this Agreement.

              (v) In determining the amount of any indemnity, there shall be 
taken into account any Tax benefit, insurance proceeds or similar recovery or
offset realized, directly or indirectly, by the Party to be indemnified.

         (d) Notice and Defense of Claims . Promptly after receipt of notice of
any claim, liability or expense for which a Party seeks indemnification
hereunder, such Party shall give written notice thereof to the indemnifying
Party (or, in the case of a claim under Section 4(a), to the Stockholders'
Representatives), but such notification shall not be a condition to
indemnification hereunder except to the extent of actual prejudice to the
indemnifying Party. The notice shall state the information then available
regarding the amount and nature of such claim, liability or expense and shall
specify the provision or provisions of the Merger Agreement under which the
liability or obligation is asserted. If, within thirty (30) days after receiving
such notice, the indemnifying Party or the Stockholders' Representatives give
written notice to the indemnified Party stating that they intend to defend
against such claim, liability or expense at its own cost and expense, then
defense of such matter, including selection of counsel (subject to the consent
of the indemnified Party which consent shall not be unreasonably withheld),
shall be by the indemnifying Party and the indemnified Party shall make no
payment on such claim, liability or expense as long as the indemnifying Party is
conducting a good faith and diligent defense. The indemnifying Party shall not
be liable to indemnify any person for any settlement of any such action effected
without the written consent of the indemnifying party, which consent shall not
be unreasonably withheld. Notwithstanding the foregoing, the indemnified Party
shall at all times have the right to fully participate in such defense at its
own expense directly or through counsel; provided, however, if the named parties
to the action or proceeding include both the indemnifying Party and the
indemnified Party and representation of both parties by the same counsel would
be inappropriate under applicable standards of professional conduct, the expense
of separate counsel for the indemnified Party shall be paid by the indemnifying
Party. If no such notice of intent to dispute and defend is given by the
indemnifying Party or the Stockholders' Representatives, or if such diligent
good faith defense is not being or ceases to be conducted, the indemnified Party
shall, at the expense of the indemnifying Party, undertake the defense of such
claim, liability or expense with counsel selected by the indemnified Party, and
shall have the right to compromise or settle the same exercising reasonable
business judgment. The indemnified Party shall make available all information
and assistance that the indemnifying Party or the Stockholders' Representatives
may reasonably request and shall cooperate with the indemnifying Party in such
defense.


                                       5
<PAGE>   6
     5.  Registration of Parent Shares.

         (a) Form S-3. The Parent represents that it is eligible to use Form S-3
under the Securities Act to effect registration of shares of Parent Common Stock
issued to the Company Stockholders pursuant to Sections 1.6(b)(i) and (iii) of
the Merger Agreement (the "Registrable Securities") for resale by the Company
Stockholders. The Parent will use its best efforts to effect the registration
and qualification of the Registrable Securities and in connection therewith, the
Parent shall:

              (i) prepare and file with the Securities and Exchange Commission 
(the "Commission") within sixty (60) days of the Closing Date, and use its best
efforts to cause to become effective as soon as possible thereafter, a
registration statement on Form S-3 (or any successor or other appropriate form)
under the Securities Act of 1933, as amended (the "Securities Act") permitting
the Registrable Securities to be offered for resale by the Company Stockholders;

              (ii) prepare and file with the Commission, such amendments and
supplements to such registration statement and the prospectus used in connection
therewith, as may be necessary to keep such registration statement effective and
to comply with the provisions of the Securities Act with respect to the
disposition of all Registrable Securities until the earlier of such time as all
of such Registrable Securities have been disposed of in accordance with the
intended methods of disposition by the Company Stockholders set forth in such
registration statement or until December 31, 2001;

              (iii) furnish to each Company Stockholder, who is a holder of such
Registrable Securities (each individually a "Holder") and to any underwriter of
such Registrable Securities, such number of conformed copies of such
registration statement and of each such amendment and supplement thereto, such
number of copies of the prospectus included in such registration statement
(including each preliminary prospectus and any summary prospectus) or filed
under Rule 424(b) or Rule 424(c) under the Securities Act, in conformity with
the requirements of the Securities Act, such documents incorporated by reference
in such registration statement or prospectus, and such other documents, as any
Holder or any such underwriter may reasonably request;

              (iv) use its best efforts (1) to list all Registrable Securities
covered by such registration statement on The Nasdaq National Market, and (2) to
register or qualify all Registrable Securities covered by such registration
statement under such "blue sky" or other securities law of such jurisdictions as
any Holder or any underwriter of such Registrable Securities will reasonably
request, and do any and all other acts and things which may be necessary to
enable any Holder or any underwriter to consummate the disposition in such
jurisdictions of the Registrable Securities covered by such registration
statement, except that the Parent shall not for any such purpose be required to
qualify generally to do business as a foreign corporation in any jurisdiction
wherein it is not so qualified, or to subject itself to taxation in any such
jurisdiction or to consent to general service of process in any such
jurisdiction;

              (v) promptly notify the Holders, at any time of the occurrence, 
of any event as a result of which the portion of the prospectus included in such
registration statement which contains information furnished by or relating to
the Parent, as then in effect, includes an untrue 



                                       6
<PAGE>   7
statement of a material fact or omits to state any material fact required to be
stated therein or necessary to make the statements therein not misleading in the
light of the circumstances then existing and, at the request of a Holder,
prepare and furnish to such Holder a reasonable number of copies of a supplement
to, or an amendment of, such prospectus as may be necessary so that, as
thereafter delivered to the purchasers of such Registrable Securities, such
prospectus will not include an untrue statement of a material fact or omit to
state a material fact required to be stated therein or necessary to make the
statements therein not misleading in the light of the circumstances then
existing; and

              (vi) The Parent may require each Holder to furnish the Parent such
information regarding himself, herself or itself and the distribution of such
Registrable Securities as the Parent may from time to time reasonably request in
writing and as will be required by law or by the Commission in connection with
any registration.

         (b) Compliance with Securities Laws. Each of the Holders acknowledges
that he, she or it will be subject to applicable provisions of the Securities
Act and the Exchange Act.

         (c) Exchange Act Reports and Availability of Rule 144. During the
period from the Closing Date until the date which is five years following the
Closing Date, the Parent shall use its best efforts to (i) timely file all
reports required to be filed by the Parent under the Securities Exchange Act of
1934, as amended (the "Exchange Act") and (ii) take such other action and
coordinate with the Holders to ensure that Rule 144 shall be available to the
Holders for the purpose of disposing of their Registrable Securities.

         (d) Discontinuation of Disposition of Registrable Securities. Each
Holder will, upon receipt of any notice from the Parent of the occurrence of any
event of the kind described in Section 5(a)(v) hereof, discontinue disposition
of Registrable Securities pursuant to the registration statement covering such
Registrable Securities until Holder's receipt of the copies of the supplemented
or amended prospectus contemplated by Section 5(a)(v) herein, which supplemented
or amended prospectus shall be made available to Holder as soon as practicable.
The period of time during which the Parent is obligated to maintain the
effectiveness of a registration statement under Section 5(a)(ii) above shall be
extended by the number of days of any such discontinuance.

         (e) Obligation of the Parent and the Acquisition Sub to Indemnify. The
Parent agrees to indemnify and hold harmless each Holder or any Person who
participates as an underwriter in the offering or sale of such Registrable
Securities, each officer and director of each underwriter, and each other
Person, if any, who "controls" each Holder or any such underwriter within the
meaning of the Securities Act against any losses, claims, damages, liabilities
and expenses, joint or several, to which such Person may be subject under the
Securities Act or otherwise insofar as such losses, claims, damages, liabilities
(or actions or proceedings in respect thereof) or expenses arise out of or are
based upon (i) any untrue statement or alleged untrue statement of any material
fact contained in any registration statement under which such Registrable
Securities were registered under the Securities Act, any preliminary prospectus
or final prospectus included therein or filed under Rule 424(b) under the
Securities Act, or any amendment or supplement thereto, or any document
incorporated by reference therein, or (ii) any omission or alleged omission to
state therein a material fact required to be stated therein or necessary to make
the statements therein not misleading, and the Parent will reimburse each such
Person for any legal or any other expenses 


                                       7
<PAGE>   8
reasonably incurred by them in connection with investigating or defending any
such loss, claim, liability, action or proceeding; provided, however, that the
Parent will not be liable in any such case to the extent that any such loss,
claim, damage, liability (or action or proceeding in respect thereof) or expense
arises out of or is based upon (i) an untrue statement or alleged untrue
statement or omission or alleged omission made in such registration statement,
any such preliminary prospectus or final prospectus, amendment or supplement in
reliance upon and in conformity with written information furnished to the Parent
by any Holder or any such underwriter or any Person who "controls" any such
Holder or underwriter for use in the preparation thereof, (ii) any breach by any
Holder of the covenant set forth in Section 5(d) hereof. Such indemnity will
remain in full force and effect regardless of any investigation made by, or on
behalf of, any Holder or any such underwriter and will survive the transfer of
such Registrable Securities by Holder.

         (f) Obligation of the Company Stockholders to Indemnify. Each Holder
severally, and not jointly, and in proportion to the Registrable Securities
actually sold by such Holder thereunder, agrees to indemnify and hold harmless
the Parent, each director and each officer of the Parent, and each controlling
person within the meaning of the Securities Act of any of the foregoing who will
sign such registration statement, against any losses, claims, damages,
liabilities and expenses, joint or several, to which such Person may be subject
under the Securities Act or otherwise insofar as such losses, claims, damages,
liabilities (or actions or proceedings in respect thereof) or expenses arise out
of, or are based upon, (i) any untrue statement or alleged untrue statement of
any material fact contained in any registration statement under which such
Registrable Securities were registered under the Securities Act, any preliminary
prospectus or final prospectus included therein or filed under Rule 424(b) under
the Securities Act, or any amendment or supplement thereto, or any document
incorporated by reference therein, (ii) any omission or alleged omission to
state therein a material fact required to be stated therein or necessary to make
the statements therein not misleading, (iii) any breach by any Holder of the
covenant set forth in Section 5(d) hereof or (iv) any failure by any Holder to
deliver a prospectus as required under the Securities Act or any state
securities laws. Holder will reimburse each such Person for any legal or any
other expenses reasonably incurred by them in connection with investigating or
defending any such loss, claim, liability, action or proceeding; provided,
however, that Holder will be liable in any such case only to the extent that any
such loss, claim, damage, liability (or action or proceeding in respect thereof)
or expense arises out of or is based upon an untrue statement or alleged untrue
statement or omission or alleged omission made in such registration statement,
any such preliminary prospectus or final prospectus, amendment or supplement, in
reliance upon and in conformity with written information specifically furnished
to the Parent by Holder or any Person who "controls" such Holder for use in the
preparation thereof. Such indemnity will remain in full force and effect
regardless of any investigation made by or on behalf of the Parent and will
survive the transfer of such Registrable Securities by Holder.

         (g) Notice and Defense of Claims. Promptly after receipt of notice of
any claim, liability or expense arising out of the registration or sale of the
Registrable Securities for which a Party seeks indemnification hereunder, such
Party shall give written notice thereof to the indemnifying Party (or, in the
case of a claim under Section 5(f), to the Stockholders' Representatives), but
such notification shall not be a condition to indemnification hereunder except
to the extent of actual prejudice to the indemnifying Party. The notice shall
state the information then available regarding the amount and nature of such
claim, liability or expense. If within thirty 



                                       8
<PAGE>   9
(30) days after receiving such notice the indemnifying Party or the
Stockholders' Representatives give written notice to the indemnified Party
stating that they intend to defend against such claim, liability or expense at
its own cost and expense, then defense of such matter, including selection of
counsel (subject to the consent of the indemnified Party which consent shall not
be unreasonably withheld), shall be by the indemnifying Party and the
indemnified Party shall make no payment on such claim, liability or expense as
long as the indemnifying Party is conducting a good faith and diligent defense.
The indemnifying Party shall not be liable to indemnify any person for any
settlement of any such action effected without the written consent of the
indemnifying party, which consent shall not be unreasonably withheld.
Notwithstanding the foregoing, the indemnified Party shall, at all times, have
the right to fully participate in such defense at its own expense directly or
through counsel; provided, however, if the named parties to the action or
proceeding include both the indemnifying Party and the indemnified Party and
representation of both parties by the same counsel would be inappropriate under
applicable standards of professional conduct, the expense of separate counsel
for the indemnified Party shall be paid by the indemnifying Party. If no such
notice of intent to dispute and defend is given by the indemnifying Party or the
Stockholders' Representatives, or if such diligent, good faith defense is not
being or ceases to be conducted, the indemnified Party shall, at the expense of
the indemnifying Party, undertake the defense of such claim, liability or
expense with counsel selected by the indemnified Party, and shall have the right
to compromise or settle the same exercising reasonable business judgment. The
indemnified Party shall make available all information and assistance that the
indemnifying Party or the Stockholders' Representatives may reasonably request
and shall cooperate with the indemnifying Party in such defense.

         (h) Contribution. If the indemnification provided for in this Section 5
is held by a court of competent jurisdiction to be unavailable to an indemnified
Party with respect to any loss, liability, claim, damage, or expense referred to
therein, then the indemnifying Party, in lieu of indemnifying such indemnified
Party hereunder, shall contribute to the amount paid or payable by such
indemnified Party as a result of such loss, liability, claim, damage, or expense
in such proportion as is appropriate to reflect the relative fault of the
indemnifying Party, on the one hand, and of the indemnified Party, on the other,
in connection with the statements or omissions that resulted in such loss,
liability, claim, damage, or expense as well as any other relevant equitable
considerations. The relative fault of the indemnifying Party and of the
indemnified Party shall be determined by reference to, among other things,
whether the untrue or alleged untrue statement of a material fact or the
omission to state a material fact relates to information supplied by the
indemnifying Party or by the indemnified Party and the parties' relative intent,
knowledge, access to information, and opportunity to correct or prevent such
statement or omission.

         (i) Other Securities Laws. Indemnification and contribution similar to
that specified in the paragraphs (c), (d) and (f) of this Section 5 (with
appropriate modifications) will be given by the Parent and each Holder with
respect to any required registration or other qualification of such Registrable
Securities under any federal or state law or regulation of any governmental
authority other than the Securities Act.

         (j) Covenant to Register Option Securities. The Parent will use its
best efforts to effect the registration of shares of Parent Common Stock
issuable upon exercise of options to acquire Parent Common Stock issued pursuant
to Section 1.6.(b)(ii) of the Merger Agreement (the "Option Securities"). The
Parent will prepare and file with the Commission within sixty (60) days of the

                                       9
<PAGE>   10
Closing Date, and use best efforts to cause to become effective as soon as
possible thereafter, a registration statement on Form S-3 (or any other
appropriate form) under the Securities Act. The Parent will prepare and file
with the Commission, such amendments and supplements to such registration
statement and the prospectus used in connection therewith, as may be necessary
to keep such registration statement effective until the earlier of such time as
all of such Option Securities have been disposed of in accordance with the
intended method of disposition set forth in such registration statement or until
May 31, 2002. The Parent will use its efforts to list all Option Securities
covered by such registration statement on the Nasdaq National Market.
Notwithstanding anything to the contrary herein, the provisions of Sections 5(d)
through 5(i) of this Agreement shall not apply with respect to the registration
of such Option Securities.

     6.  M.I.T. and the M.I.T. Holders.

         (a) The Massachusetts Institute of Technology ("MIT") represents and
warrants that the Company has satisfied all of its obligations arising or
occurring up to the date hereof under the Patent License Agreement between the
Company and MIT dated August 15, 1997, as amended (the "M.I.T. Agreement") or,
if any such obligations have not been satisfied, are hereby waived.

         (b) The Holders listed on Schedule 6 hereto (the "M.I.T. Holders"),
hereby (i) acknowledge that the Dilutive Issuance Threshold has been met and
satisfied pursuant to the terms of the M.I.T. Agreement, (ii) each M.I.T.
Holder's pro rata ownership rights under Section 4.1(b) of the M.I.T. Agreement
were satisfied in full, and (iii) waive any and all past, present and future
rights, both accrued and unaccrued, under Section 4.1(b) of the M.I.T.
Agreement.

     7.  Termination of Certain Existing Agreements.

         (a) Stockholders' Agreement. The Company and the undersigned Company
Stockholders agree that the certain Stockholders' Agreement dated July 31, 1997,
as amended, shall be hereby further amended so that such Stockholders' Agreement
shall automatically terminate in its entirety immediately prior to the Effective
Time, without any further action on the part of the Company or such Company
Stockholders.

         (b) Co-Sale Agreement. The Company and the undersigned Company
Stockholders who are parties to that certain Co-Sale Agreement dated July 31,
1997, as amended, agree that such Co-Sale Agreement shall be hereby further
amended so that such Co-Sale Agreement shall automatically terminate in its
entirety effective immediately prior to the Effective Time, without any further
action on the part of the Company or such Company Stockholders.

         (c) Investors' Rights Agreement. The Company and the undersigned
Company Stockholders who are parties to that certain Amended and Restated
Investors' Rights Agreement dated as of November 28, 1998 agree that such
Amended and Restated Investors' Rights Agreement shall be hereby further amended
so that such Amended and Restated Investors' Rights Agreement, including the
provisions of Sections 3 and 6 thereof, shall terminate in its entirety
effective immediately prior to the Effective Time, without any further action on
the part of the Company or such Company Stockholders.

                                       10
<PAGE>   11
         (d) Management Rights Letters. The Company, Polaris Venture Partners,
L.P. and Polaris Venture Partners Founders' Fund, L.P. agree that those certain
Management Rights Letters dated July 31, 1997, April 6, 1998 and June 29, 1998
among such parties shall hereby be amended so that such Management Rights
Letters shall terminate in their entirety effective immediately prior to the
Effective Time, without any further action on the part of any such party.

     8.  Stockholders' Representatives.

         (a) Appointment and Acceptance. Each Company Stockholder hereby
appoints David A. Edwards and Terrance McGuire to act as his or her
representatives (the "Stockholders' Representatives") as contemplated by this
Agreement in connection with all matters relating to the Merger. Without
limiting the generality of the foregoing, the Stockholders' Representatives are
authorized to represent the Company Stockholders in connection with (i) any
indemnification claim against or by the Company Stockholders pursuant to the
Merger Agreement and this Agreement; (ii) the administration of the Merger
Agreement and this Agreement and any disputes or issues that arise hereunder or
thereunder. The Stockholders' Representatives hereby accept such appointment and
agree to serve as the Stockholders' Representatives as contemplated by this
Agreement.

         (b) Indemnification Claims. The Stockholders' Representatives may, but
are not obligated to enforce, collect or recover any claim as to which indemnity
may be sought on behalf of the Company Stockholders under this Agreement and the
Merger Agreement. The Stockholders' Representatives shall in no event have any
obligation for the payment of, or the collection of, any amounts to which the
Company Stockholders may be entitled under this Agreement or the Merger
Agreement, except for in their capacity as Company Stockholders.

         (c) Limitation on Powers. Notwithstanding anything in this Agreement to
the contrary, the Stockholders' Representatives shall not have the authority to
waive, or agree to any amendment to, the Company Stockholders' rights under the
Merger Agreement or this Agreement except that the settlement of a bona fide
dispute relating to the rights to which the Company Stockholders are entitled
shall not constitute a "waiver" or "amendment" of any rights subject to this
paragraph (c).

         (d) Power of Attorney. Subject to Section 8(c) above, the Stockholders'
Representatives shall have full power and authority for the Company
Stockholders, on his or her behalf and in his or her name, place and stead, to
take any and all actions that the Stockholders' Representatives may deem
necessary or desirable under the Merger Agreement and this Agreement, in its
absolute discretion, as fully as the Company Stockholders could do if present.
The Company Stockholders hereby grant each Stockholders' Representative, acting
individually after the approval of a matter by the Stockholders' Representatives
as provided herein, an irrevocable power of attorney, in the name, place and
stead of the Company Stockholders, to execute and deliver any agreements,
waivers, stock certificates or other documents, to commence and defend
litigation and other proceedings, and to take such other actions as are
necessary or desirable to enforce or protect the Company Stockholders' rights
under the Merger Agreement and this Agreement and to implement decisions made or
actions taken by the Stockholders' Representatives.



                                       11
<PAGE>   12
         (e) Ratification. Any action taken by the Stockholders' Representatives
or any Stockholders' Representative pursuant to and in compliance with this
Agreement is hereby ratified, confirmed and approved by the Company
Stockholders.

         (f) Reliance; Irrevocability. It is anticipated that the Stockholders'
Representatives, Parent, and the other Company Stockholders will all act, or
refrain from acting, in reliance upon this Section 8, and in consideration of
that reliance, and the mutual covenants expressed in this Section 8, the powers
of the Stockholders' Representatives are, and shall be deemed, coupled with an
interest and irrevocable, and shall not terminate upon, or be affected by, the
dissolution, death, incompetency or other disability of the Company
Stockholders.

         (g) Action by the Stockholders' Representatives.

              (i) Only by Mutual Consent. The Stockholders' Representatives may 
act only by mutual consent; provided, however, that each Stockholders'
Representatives may individually implement actions approved by mutual consent.

              (ii) Reliance on Documents. The Stockholders' Representatives 
shall be entitled to rely upon any order, judgment, award, certification,
demand, notice, instrument or other writing delivered to it under this Agreement
or the Merger Agreement without being required to determine the authenticity or
the correctness of any fact stated therein or the propriety or validity of the
service thereof. The Stockholders' Representatives may act in reliance upon any
instrument or signature believed by it to be genuine and may assume that any
persons purporting to give notice or receipt of advice or make any statement or
execute any document in connection with the provisions hereof have been duly
authorized to do so.

              (iii) Retaining Third-Parties. The Stockholders' Representatives 
may engage such third parties at such cost as the Stockholders' Representatives
shall in their sole discretion deem necessary or appropriate for the adequate
performance of their duties hereunder and may rely on the advice of such third
parties with respect to matters within their professional or expert competence.

         (h) Release and Indemnification.

              (i) Release and Indemnification. No Stockholders' Representative 
shall be liable to the Company Stockholders for any acts or omissions as
Stockholders' Representatives except for his or her own bad faith or willful
misconduct. Except with respect to claims based upon such bad faith or willful
misconduct that are successfully asserted against such Stockholders'
Representative, the Company Stockholders shall jointly and severally indemnify
and hold harmless each Stockholders' Representative from and against any and all
damages, losses, liabilities, claims, actions, costs and expenses, including
reasonable attorneys' fees and disbursements, arising out of and in connection
with this Agreement or the Merger Agreement and the performance of his or her
duties hereunder. Such Stockholders' Representative shall not be liable for any
mistake of fact or of law or any error of judgment. Each Stockholders'
Representative and the Stockholders' Representatives are authorized to comply
with and obey laws, orders, judgments, decrees, and regulations of any
governmental authority, court, tribunal, or arbitrator. If a Stockholders'
Representative complies with any such law, order, judgment, decree, or
regulation, such 



                                       12
<PAGE>   13
Stockholders' Representative shall not be liable to the Company Stockholders or
to any other person even if such law, order, judgment, decree or regulation is
subsequently reversed, modified, annulled, set aside, vacated, found to have
been entered without jurisdiction, or found to be in violation or beyond the
scope of any constitution or law. If (A) a Stockholders' Representative is
uncertain as to the Stockholders' Representatives' duties or rights hereunder,
(B) has received any notice, advice, direction or other document from any other
party with respect to this Agreement or the Merger Agreement which, in the
Stockholders' Representative's opinion, is in conflict with any of the
provisions of this Agreement or the Merger Agreement, or (C) is aware that a
dispute has arisen with respect to this Agreement and the Merger Agreement, each
Stockholders' Representative and the Stockholders' Representatives shall be
entitled, without liability to the Company Stockholders, to use their best
efforts to perform their duties under this Agreement, the Merger Agreement until
the Stockholders' Representatives are directed otherwise in writing by an order,
decree, or judgment of a court of competent jurisdiction which has been finally
affirmed on appeal or which by lapse of time or otherwise is no longer subject
to appeal or by an arbitrator's determination as provided in this Agreement.

         (ii) Period of Indemnity. The aforesaid indemnities shall remain in
full force and effect against any of the parties for a period equal to the
applicable statute of limitation for such claim; provided, however, that if
prior to the expiration of such period any claim for indemnification has been
asserted but not fully determined, such period will be extended as to such
claim, until it is finally concluded. All rights, protections and indemnities
contemplated herein shall be available to each Stockholders' Representative with
respect to actions or omissions while a Stockholders' Representative despite
such Stockholders' Representative's resignation or removal as a Stockholders'
Representative.

         (iii) Satisfaction of Indemnification Obligations. The obligations of
the Company Stockholders to indemnify the Stockholders' Representatives shall be
satisfied in the same manner as indemnification claims made by the Parent
against the Company Stockholders are satisfied. If a Stockholders'
Representative is entitled to indemnification after all such amounts are
exhausted, each Company Stockholder (other than the indemnified Stockholders'
Representative(s)) shall be individually liable in an amount equal to the amount
of indemnification multiplied by a fraction, the numerator of which this the
number of share of Common Stock owned by such Company Stockholder and the
denominator of which is the number of shares of Common Stock owned by all of the
Company Stockholders (other than the indemnified Stockholders'
Representative(s)).

     (i)  Resignation and Removal; Appointment of Successors.

          (i)  Resignation. Any Stockholders' Representative may resign at any 
time by giving 30 days written notice thereof to the other Stockholders'
Representative.

          (ii)  Filling Vacancies. If any Stockholders' Representative shall 
resign, be removed or become incapable of acting, or if a vacancy in the office
of Stockholder Representative shall otherwise occur, the remaining Stockholders'
Representative shall appoint a successor to take the place of such Stockholders'
Representative and fill such vacancy. Such successor Stockholders'
Representative shall execute a counterpart to this Agreement and thereupon,
without any further act, deed or conveyance, shall become vested with all the
rights, powers and 



                                       13
<PAGE>   14
duties of the retiring Stockholders' Representative. If both Stockholders'
Representatives resign or are otherwise unable to act, the Company Stockholders
may appoint new Stockholders' Representatives to the Stockholders'
Representatives by a plurality vote at a meeting of, or written consent by,
Company Stockholders holding a majority of the shares of Company Common Stock.

     9.  Termination. This Agreement shall terminate if and only if the
Merger Agreement is terminated prior to the Closing in accordance with and
pursuant to the terms thereof.

     10.  Miscellaneous.

         (a) No Third Party Beneficiaries. This Agreement shall not confer any
rights or remedies upon any Person other than the Parties and their respective
successors, heirs and permitted assigns.

         (b) Entire Agreement. This Agreement (including the documents referred
to herein) constitutes the entire agreement among the Parties and except for the
Merger Agreement supersedes any prior understandings, agreements, or
representations by or among the Parties, written or oral, to the extent they
related in any way to the subject matter hereof.

         (c) Succession and Assignment. This Agreement shall be binding upon and
inure to the benefit of the Parties named herein and their respective successors
and permitted assigns. No Party may assign either this Agreement or any of his,
her or its rights, interests or obligations hereunder without the prior written
approval of the Parent and the Requisite Company Stockholders; provided,
however, that the Parent may assign any or all of its rights and interests
hereunder in connection with any merger, consolidation or sale of all or
substantially all of its assets.

         (d) Counterparts. This Agreement may be executed in one or more
counterparts, each of which shall be deemed an original but all of which
together will constitute one and the same instrument.

         (e) Headings. The section headings contained in this Agreement are
inserted for convenience only and shall not affect in any way the meaning or
interpretation of this Agreement.

         (f) Notices. All notices, requests, demands, claims, and other
communications hereunder will be in writing. Any notice, request, demand, claim,
or other communication hereunder shall be deemed duly given (and then received
two business days thereafter) if it is sent by registered or certified mail,
return receipt requested, postage prepaid, and addressed to the intended
recipient as set forth below:

<TABLE>
<S>                              <C>
If to the Company:               Advanced Inhalation Research, Inc.
                                 840 Memorial Drive
                                 Cambridge, MA  02139
                                 Attn:  President
                                 Facsimile:  (617) 354-6444
</TABLE>

If to the Company Stockholders: At the address set forth in the Company's
records

                                       14
<PAGE>   15
<TABLE>
<S>                                      <C>
If to the Parent:                         Alkermes, Inc.
                                          64 Sidney Street
                                          Cambridge, MA  02139
                                          Attn:  Chief Financial Officer
                                          Facsimile:  (617) 494-9255

Copy to:                                  Ballard Spahr Andrews & Ingersoll, LLP
                                          1735 Market Street, 51st Floor
                                          Philadelphia, PA 19103
                                          Attn:    Morris Cheston, Jr., Esquire
                                          Facsimile:  (215) 864-8999

If to the Stockholders' Representatives   David A. Edwards
                                          President
                                          Advanced Inhalation Research
                                          840 Memorial Drive
                                          Cambridge, MA 02139

                                          Terrance McGuire
                                          Polaris Venture Partners
                                          1000 Winter Street, Suite 3350
                                          Waltham, MA 02154
</TABLE>


Any Party may send any notice, request, demand, claim or other communication
hereunder to the intended recipient at the address set forth above using any
other means (including personal delivery, expedited courier, messenger service,
telecopy, telex, ordinary mail, or electronic mail), but no such notice,
request, demand, claim or other communication shall be deemed to have been duly
given unless and until it actually is received by the intended recipient. Any
Party may change the address to which notices, requests, demands, claims and
other communications hereunder are to be delivered by giving the other Parties
notice in the manner herein set forth.

         (g) Governing Law. This Agreement shall be governed by and construed in
accordance with the domestic laws of the Commonwealth of Pennsylvania without
giving effect to any choice or conflict of law provision or rule (whether of the
Commonwealth of Pennsylvania or any other jurisdiction) that would cause the
application of the laws of any jurisdiction other than the Commonwealth of
Pennsylvania.

         (h) Amendments and Waivers. No amendment of any provision of this
Agreement shall be valid unless the same shall be in writing and signed by the
Parent and the Requisite Company Stockholders. No waiver by any Party of any
default, misrepresentation, or breach of warranty or covenant hereunder, whether
intentional or not, shall be deemed to extend to any prior or subsequent
default, misrepresentation, or breach of warranty or covenant hereunder or
affect in any way any rights arising by virtue of any prior or subsequent such
occurrence.

         (i) Severability. Any term or provision of this Agreement that is
invalid or unenforceable in any situation in any jurisdiction shall not affect
the validity or enforceability of the 



                                       15
<PAGE>   16
remaining terms and provisions hereof or the validity or enforceability of the
offending term or provision in any other situation or in any other jurisdiction.

         (j) Expenses. Each of the Parties will bear his, her or its own costs
and expenses (including legal fees and expenses) incurred in connection with
this Agreement and the transactions contemplated hereby (except as otherwise
provided herein).

         (k) Construction. The Parties have participated jointly in the
negotiation and drafting of this Agreement. In the event an ambiguity or
question of intent or interpretation arises, this Agreement shall be construed
as if drafted jointly by the Parties and no presumption or burden of proof shall
arise favoring or disfavoring any Party by virtue of the authorship of any of
the provisions of this Agreement. Any reference to any federal, state, local, or
foreign statute or law shall be deemed also to refer to all rules and
regulations promulgated thereunder, unless the context requires otherwise. The
word "including" shall mean including without limitation.

                                      *****




                                       16


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