ALKERMES INC
424B3, 1999-05-21
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1

Prospectus Supplement No. 10
to Prospectus dated April 27, 1998

                                 ALKERMES, INC.
       2,300,000 SHARES OF $3.25 CONVERTIBLE EXCHANGEABLE PREFERRED STOCK
             $115,000,000 6 1/2% CONVERTIBLE SUBORDINATED DEBENTURES
                        3,881,940 SHARES OF COMMON STOCK

         This Prospectus Supplement supplements information contained in that
certain Prospectus of Alkermes, Inc. (the "Company") dated April 27, 1998 (the
"Prospectus") relating to the potential resale from time to time of $3.25
Convertible Exchangeable Preferred Stock, par value $.01 per share (the
"Preferred Stock"), 6 1/2% Convertible Subordinated Debentures (if issued) (the
"Debentures") and Common Stock (the "Common Stock") issuable upon conversion of
the Preferred Stock or Debentures (if issued). This Prospectus Supplement is not
complete without, and may not be delivered or utilized except in connection
with, the Prospectus, including any amendments or supplements thereto.
Capitalized terms used herein but not defined have the meanings assigned to such
terms in the Prospectus.

         The following table supplements the information set forth in the
Prospectus under the caption "Selling Shareholders" with respect to the Selling
Shareholders and the respective amount of shares of Preferred Stock beneficially
owned by each Selling Shareholder and that may be sold, the principal amount of
Debentures which would be beneficially owned and may be sold by each Selling
Shareholder, and number of shares of Common Stock that may be sold by the
Selling Shareholders pursuant to this Prospectus, as amended or supplemented:

<TABLE>
<CAPTION>


                                      NUMBER OF
                                      SHARES OF                          PRINCIPAL
                                      PREFERRED                          AMOUNT OF
                                        STOCK                            DEBENTURES          NUMBER OF
                                     BENEFICIALLY      PERCENT OF       BENEFICIALLY        CONVERSION
                                      OWNED AND        OUTSTANDING       OWNED AND            SHARES
                                       THAT MAY         PREFERRED         THAT MAY           THAT MAY
NAME (1)                               BE SOLD           STOCK            BE SOLD           BE SOLD (2)
- --------                             ------------      -----------      ------------        -----------
<S>                                      <C>             <C>              <C>                  <C>
Bear, Stearns & Co., Inc.                400                *             $20,000               675
</TABLE>

- ------------------
 *  Less than 1%.

(1) The information set forth herein is as of May 20, 1999 and will be
    updated as required. 
(2) Assumes conversion of the full amount of Preferred Stock held by such holder
    at the initial conversion rate of 1.6878 shares of Common Stock for each 
    share of Preferred Stock.


             THE DATE OF THIS PROSPECTUS SUPPLEMENT IS MAY 21, 1999




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