<PAGE> 1
Prospectus Supplement No. 4 Filed pursuant to Rule 424(b)(3)
to Prospectus dated March 6, 2000 Registration No. 333-31354
ALKERMES, INC.
$250,000,000 3 3/4% CONVERTIBLE SUBORDINATED NOTES DUE 2007
1,845,018 SHARES OF COMMON STOCK
This prospectus supplement supplements the information contained in the
prospectus of Alkermes, Inc. dated March 6, 2000, as supplemented by Prospectus
Supplement No. 1 dated March 10, 2000, Prospectus Supplement No. 2 dated March
17, 2000 and Prospectus Supplement No. 3 dated March 24, 2000, relating to the
potential resale from time to time of the 3 3/4% Convertible Subordinated Notes
due 2007 of Alkermes and the resale of shares of common stock of Alkermes
issuable upon conversion of the notes. This prospectus supplement is not
complete without, and may not be delivered or utilized except in connection
with, the prospectus, including any amendments or supplements thereto.
The following table supplements the information set forth in the prospectus
under the caption "Selling Securityholders" with respect to the selling
securityholders and the respective principal amount of notes which are
beneficially owned and may be sold by each selling securityholder, and the
number of shares of common stock that may be sold by the selling securityholders
pursuant to this prospectus, as amended or supplemented:
<TABLE>
<CAPTION>
Number of Shares of Common
Principal Amount of Notes Stock Issued Upon Conversion
Beneficially Owned and of the Notes that May be
Name of Selling Securityholder(1) Offered Offered(2)
<S> <C> <C>
Angelo, Gordon & Co., L.P. $ 700,000 5,166
MichaelAngelo, L.P. 2,100,000 15,498
RCG Multi-Strategy Account, L.P. 700,000 5,166
</TABLE>
(1) The information set forth herein is as of April 5, 2000 and will be
updated as required.
(2) Assumes conversion of the full principal amount of the notes held by such
holder at the initial conversion price of $135.50 per share of common
stock.
THE DATE OF THIS PROSPECTUS SUPPLEMENT IS APRIL 5, 2000
