OSTEOTECH INC
10-Q, 1997-08-13
MISC HEALTH & ALLIED SERVICES, NEC
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM 10-Q


                                   (Mark One)

[x]      Quarterly Report Pursuant to Section 13 or 15(d) of the Securities
Exchange Act of 1934 For the Period Ended June 30, 1997


                                       or

[ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange
Act of 1934 For the Transition Period from __________ to __________


                         Commission File Number 0-19278


                                 OSTEOTECH, INC.
             (Exact name of registrant as specified in its charter)

           Delaware                                        13-3357370
 (State or other jurisdiction of                      (I.R.S. Employer
  incorporation or organization)                       Identification No.)

  51 James Way, Eatontown, New Jersey                           07724
    (Address of principal executive offices)                  (Zip Code)

                                 (908) 542-2800
              (Registrant's telephone number, including area code)

                                 Not Applicable
     (Former name, former address and former fiscal year, if changed since
                                  last report)

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  registrant  was
required  to file  such  reports),  and  (2) has  been  subject  to such  filing
requirements for the past 90 days. Yes X No

                      Applicable Only to Corporate Issuers

Indicate the number of shares  outstanding  of each of the  issuer's  classes of
common stock, as of the latest practical date.

Common Stock, $.01 par value - 8,162,758 shares as of July 31, 1997


<PAGE>



PART I.       FINANCIAL INFORMATION

ITEM 1.       FINANCIAL STATEMENTS

                        OSTEOTECH, INC. AND SUBSIDIARIES
                      CONDENSED CONSOLIDATED BALANCE SHEETS
                                   (unaudited)
                             (dollars in thousands)
<TABLE>
<CAPTION>

                                                                                June 30,            December 31,
                                                                                 1997                  1996
- ----------------------------------------------------------------------------------------------------------------
ASSETS
- ----------------------------------------------------------------------------------------------------------------
Current assets:
<S>                                                                               <C>                   <C>    
     Cash and cash equivalents                                                    $ 7,953               $ 7,290
     Short-term investments                                                         3,445                 1,987
     Accounts receivable, net                                                       6,078                 6,280
     Prepaid expenses and other current assets                                      3,997                 4,374
                                                                      ------------------------------------------
        Total current assets                                                       21,473                19,931

Equipment and leasehold improvements, net                                           8,557                 8,170
Excess of cost over net assets of business acquired,
     less accumulated amortization of $1,323 in 1997
     and $1,197 in 1996                                                             2,375                 2,501
Other assets                                                                          922                   881
================================================================================================================
Total assets                                                                      $33,327               $31,483
================================================================================================================

LIABILITIES AND STOCKHOLDERS' EQUITY
- ----------------------------------------------------------------------------------------------------------------
Current liabilities:
     Accounts payable and accrued liabilities                                     $ 5,977               $ 6,247
     Notes payable                                                                    218                   655
     Current maturities of long-term debt and
          obligations under capital leases                                            679                   756
                                                                      ------------------------------------------
        Total current liabilities                                                   6,874                 7,658

Long-term debt and obligations under capital leases                                   517                   840
Other liabilities                                                                     261                   268
- ----------------------------------------------------------------------------------------------------------------
Total liabilities                                                                   7,652                 8,766
- ----------------------------------------------------------------------------------------------------------------

Commitments and contingencies

Stockholders' equity:
     Preferred stock, $.01 par value; 5,676,595 shares
         authorized; no shares issued or outstanding
     Common stock, $.01 par value; 20,000,000 shares
         authorized; issued and outstanding 7,970,243
         shares in 1997 and 7,826,779 shares in 1996                                   80                    78
     Additional paid-in capital                                                    30,961                30,288
     Currency translation adjustments                                                (65)                 (113)
     Accumulated deficit                                                          (5,301)               (7,536)
- ----------------------------------------------------------------------------------------------------------------
Total stockholders' equity                                                         25,675                22,717
                                                                      ------------------------------------------
======================================================================
Total liabilities and stockholders' equity                                        $33,327               $31,483
================================================================================================================
</TABLE>


     See accompanying notes to condensed consolidated financial statements.

                                       -2-


<PAGE>
                        OSTEOTECH, INC. AND SUBSIDIARIES
                 CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                                   (unaudited)
                  (dollars in thousands, except per share data)


<TABLE>
<CAPTION>

                                                         Three Months                        Six Months
                                                        Ended June 30,                     Ended June 30,
                                                --------------------------------   --------------------------------
                                                     1997             1996              1997             1996
- -------------------------------------------------------------------------------------------------------------------
Net Revenues:
<S>                                                    <C>               <C>              <C>              <C>    
     Service                                           $ 9,887           $7,578           $19,365          $15,101
     Product                                               559              641             1,165            1,365
     License fee                                           257                                257
     Grant                                                                  156                                318
                                                ---------------  ---------------   ---------------  ---------------
                                                       $10,703            8,375            20,787           16,784
Costs and expenses:
     Cost of services                                    3,526            3,063             6,946            6,127
     Cost of products                                      410              552               862            1,085
     Marketing, general and administrative               3,831            2,984             7,629            6,140
     Research and development                              890            1,122             1,826            2,183
                                                ---------------  ---------------   ---------------  ---------------
                                                         8,657            7,721            17,263           15,535


Other income (expense):
     Interest income                                       138              105               269              209
     Interest expense                                     (31)             (61)              (79)            (129)
     Other                                                  35                5                44               25
                                                ---------------  ---------------   ---------------  ---------------
                                                           142               49               234              105
                                                ---------------  ---------------   ---------------  ---------------

Income before income taxes                               2,188              703             3,758            1,354

Income tax provision                                       785              501             1,523              981

===================================================================================================================
Net income                                             $ 1,403           $  202           $ 2,235          $   373
===================================================================================================================
Net income per share:
     Primary                                              $.16             $.02              $.26             $.04
     Assuming full dilution                               $.16             $.02              $.25             $.04
Shares used in computing net income per share:
     Primary                                            8,681,882        8,319,023         8,622,475        8,354,163
     Assuming full dilution                             8,852,476        8,349,699         8,847,644        8,354,163
======================================================================================================================
</TABLE>

     See accompanying notes to condensed consolidated financial statements.

                                       -3-

<PAGE>

                        OSTEOTECH, INC. AND SUBSIDIARIES
                 CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                                   (unaudited)
                             (dollars in thousands)

<TABLE>
<CAPTION>


Six Months Ended June 30,                                                           1997              1996
- -----------------------------------------------------------------------------------------------------------------
Cash Flow From Operating Activities
<S>                                                                                    <C>               <C>    
   Net income                                                                          $ 2,235           $   373
   Adjustments to reconcile net income to net cash
      provided by (used in) operating activities:
         Depreciation and amortization                                                   1,218             1,168
         Deferred income taxes                                                            (50)               434
         Other items, net                                                                                      6
         Changes in assets and liabilities:
               Accounts receivable                                                         161             (875)
               Prepaid expenses and other current assets                                   272               505
               Accounts payable and other liabilities                                       55               716
- -----------------------------------------------------------------------------------------------------------------
Net cash provided by operating activities                                                3,891             2,327

Cash Flow From Investing Activities
   Capital expenditures                                                                (1,585)           (1,200)
   Purchases of investments                                                            (4,431)           (2,974)
   Proceeds from sale of investments                                                     2,973             6,907
   Increase in other assets                                                               (50)             (213)
- -----------------------------------------------------------------------------------------------------------------
Net cash provided by (used in) investing activities                                    (3,093)             2,520

Cash Flow From Financing Activities
   Proceeds from issuance of common stock                                                  670               324
   Proceeds from issuance of notes payable                                                  93                94
   Principal payments on notes payable                                                   (530)             (427)
   Principal payments on long-term debt
     and obligations under capital leases                                                (397)             (393)
- -----------------------------------------------------------------------------------------------------------------
Net cash used in financing activities                                                    (164)             (402)

Effect of exchange rate changes on cash                                                     29                76
- -----------------------------------------------------------------------------------------------------------------

Net increase in cash and cash equivalents                                                  663             4,521
Cash and cash equivalents at beginning of period                                         7,290             2,788
=============================================================================--==================================
Cash and cash equivalents at end of period                                              $7,953           $ 7,309
=============================================================================  ==================================
                                                                             
Supplementary cash flow data:
   Cash paid during the period for taxes                                                $1,071           $   519
   Cash paid during the period for interest                                                 87               133


</TABLE>

     See accompanying notes to condensed consolidated financial statements.


                                       -4-

<PAGE>
                        OSTEOTECH, INC. AND SUBSIDIARIES

              Notes To Condensed Consolidated Financial Statements
                                   (unaudited)


1.       Basis of Presentation
         The accompanying  unaudited condensed consolidated financial statements
         reflect all adjustments  (consisting only of normal recurring accruals)
         considered  necessary by  management  to present  fairly the  Company's
         consolidated  financial  position as of June 30, 1997 and  December 31,
         1996, and the  consolidated  results of operations for the  three-month
         and  six-month   periods  ended  June  30,  1997  and  1996,   and  the
         consolidated  cash flows for the  six-month  periods  then  ended.  The
         results  of  operations  for the  respective  interim  periods  are not
         necessarily indicative of the results to be expected for the full year.
         The  condensed  consolidated  financial  statements  should  be read in
         conjunction  with the audited  financial  statements for the year ended
         December 31, 1996 which were included as part of the  Company's  Report
         on Form 10-K.

2.      Earnings Per Share
         In February  1997,  the  Financial  Accounting  Standards  Board issued
         Statement of Financial  Accounting  Standards  No. 128,  "Earnings  Per
         Share" ("SFAS 128").  SFAS 128 establishes  standards for computing and
         presenting  earnings per share ("EPS") and  supersedes  APB Opinion No.
         15,  "Earnings  Per  Share"  ("Opinion  15").  SFAS  128  replaces  the
         presentation  of  primary  EPS with a  presentation  of basic EPS which
         excludes  dilution  and is  computed by dividing  income  available  to
         common  stockholders  by the  weighted-average  number of common shares
         outstanding  during the  period.  This  statement  also  requires  dual
         presentation  of basic EPS and  diluted  EPS on the face of the  income
         statement for all periods presented.  Diluted EPS is computed similarly
         to fully  diluted EPS pursuant to Opinion 15, with some  modifications.
         SFAS 128 is  effective  for  financial  statements  issued for  periods
         ending after  December  15,  1997,  including  interim  periods.  Early
         adoption is not permitted and the statement requires restatement of all
         prior-period EPS data presented after the effective date.

         The Company will adopt SFAS 128 effective with its financial statements
         for the year ending  December 31, 1997. If SFAS 128 had been adopted at
         June 30, 1997,  there would have been no material  change in the EPS as
         reflected  in the  accompanying  financial  statements  for the periods
         ended June 30, 1997 and 1996.

3.      Financing Arrangements
         Effective  as of May 1997,  the Company  amended its loan and  security
         agreement  with  a US  bank  which  provides  for  borrowings  under  a
         revolving line of credit and an equipment line of credit. The amendment
         extends  the term of the  agreement  through  May 1998 and  reduces the
         annual rate of interest on  equipment  advances  from the bank's  prime
         rate plus a margin of .25% to the bank's prime rate.


                                       -5-
<PAGE>
4.      Commitments and Contingencies

         Service Agreements

         Effective  April 1,  1997,  the  Company  entered  into a new five year
         exclusive  agreement  with  one  of  its  major  allograft   processing
         customers,  the Musculoskeletal  Transplant Foundation ("MTF").  During
         the first six months of 1997 and 1996,  MTF  accounted for 59% and 64%,
         respectively, of revenues.

         License and Option Agreement

         In June 1997, the Company entered into an exclusive,  worldwide license
         agreement  for  its  proprietary   PolyActive(TM)  polymer  biomaterial
         technology and patents with Matrix Medical BV, The  Netherlands.  Terms
         of the  agreement  call for the Company to receive an up front  license
         payment of 500,000 Dutch Guilders ("dfl" or  approximately  $257,000 at
         the June 30, 1997 exchange rate) and two additional license payments of
         250,000 dfl (approximately $125,000 at the June 30, 1997 exchange rate)
         each on the first and second  anniversary  of the effective date of the
         agreement. Additionally, Matrix Medical BV has an option to acquire the
         technology for 4 million dfl  (approximately $2 million at the June 30,
         1997 exchange  rate)  commencing in the third year of the agreement and
         extending through the sixth year of the agreement.

         Throughout the term of the agreement,  which is the longer of ten years
         from the first  commercial  sale of product or the life of the patents,
         Osteotech will receive a royalty of 5% of net sales, declining to 2% of
         net sales if the  option  to  purchase  the  technology  is  exercised.
         Further the agreement  requires  Matrix  Medical BV to achieve  certain
         milestones during the first three years of the agreement. Failure to do
         so will  result  in its loss of  exclusive  rights to the  patents  and
         technology.

         During June 1997 the Company the received the up front license  payment
         which was recognized as license fee revenue.

         Litigation

          The Company  has been named as a defendant  in a number of lawsuits in
          which  patients  claim  that  they  have  suffered  damages  from  the
          implantation of allegedly  defective spinal fixation devices allegedly
          distributed by the Company.  See Part II, Item 1, "Legal Proceedings".
          Management  believes  that the suits and claims are without  merit and
          intends  to  defend   such   actions   vigorously.   Pursuant  to  its
          distribution  agreement  with the  Company,  the  manufacturer  of the
          spinal fixation devices,  Heinrich C. Ulrich, KG ("Ulrich") has agreed
          to  indemnify  the Company  for all costs and damages  incurred by the
          Company in connection with its  distribution of products  manufactured
          by  Ulrich,  except  such  costs and  damages  which are caused by the
          Company's  gross  negligence  or willful  misconduct  or  unauthorized
          claims made by the Company in marketing  the  products.  Additionally,
          the Company maintains  products  liability  insurance  coverage in the
          amount of $20 million per  occurrence  and per year in the  aggregate.
          The Company's  insurance  carrier has denied  coverage with respect to
          certain  of  these  cases  and  there  can be no  assurance  that  the
          remaining  claims will be covered by the Company's  insurance  policy.
          Litigation is subject to many

                                       -6-

<PAGE>
4.      Commitments and Contingencies

         Litigation (continued)

         uncertainties  and  management  is unable to predict the outcome of the
         pending suits and claims. It is possible that the results of operations
         or liquidity  and capital  resources of the Company  could be adversely
         affected  by the  ultimate  outcome of the pending  litigation  or as a
         result  of the  costs  of  contesting  such  lawsuits  if the  ultimate
         liability  materially exceeds the amount that the Company recovers from
         Ulrich and/or its insurance coverage. The Company is unable to estimate
         the  potential  liability,  if any,  that may result  from the  pending
         litigation and, accordingly, no provision for any liability (except for
         accrued  legal  costs)  has  been  made in the  consolidated  financial
         statements.

5.      Reclassifications

          Certain of the 1996 amounts  have been  reclassified  for  comparative
          purposes.


                                       -7-

<PAGE>

Item 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
           AND RESULTS OF OPERATIONS


FOR THE THREE-MONTH AND SIX-MONTH PERIODS ENDED JUNE 30, 1997 AND 1996



Results of Operations

Net Income

Net income in the second  quarter of 1997  increased to  $1,403,000  or $.16 per
share compared to net income of $202,000 or $.02 per share in the second quarter
of 1996.  Net income in the first six months of 1997 was  $2,235,000 or $.26 per
share ($.25 assuming full  dilution)  compared to net income of $373,000 or $.04
per share in the first six months of 1996.

Following is a discussion of factors which  affected  results of operations  for
the three-month and six-month periods ended June 30, 1997 and 1996.


Revenues

Consolidated revenues in the second quarter of 1997 increased 28% to $10,703,000
from $8,375,000 in the second quarter of 1996.  Revenues in the first six months
of 1997 increased 24% to $20,787,000 from $16,784,000 in the first six months of
1996.  Domestic  revenues  increased 30% to $9,725,000 in the second  quarter of
1997  from  $7,506,000  in the  second  quarter  of 1996  and  increased  28% to
$19,129,000  in the first six months of 1997 from  $14,988,000  in the first six
months of 1996.  Foreign revenues increased 13% in the second quarter of 1997 to
$978,000 from $869,000 in the second quarter of 1996 and decreased 8% in the six
months ended June 30, 1997 to $1,658,000 from $1,796,000 in the six months ended
June 30, 1996.

The increase in domestic revenues resulted principally from increased demand for
the Company's proprietary  Grafton(R)  Demineralized Bone Matrix (DBM) allograft
processing services which increased 75% in the second quarter of 1997 and 65% in
the first six months of 1997 as compared to the same periods in 1996.

Foreign  revenues in the second  quarter  and first six months of 1997  included
$257,000 from licensing the Company's proprietary PolyActive polymer technology.
Foreign revenues in 1996 included grant revenues of $156,000 and $318,000 in the
second  quarter and first six months,  respectively,  which did not  continue in
1997 as a result  of the  discontinuance  of the  Company's  PolyActive  polymer
research and  development  program in the fourth quarter of 1996.  Additionally,
foreign revenues in the second quarter and first six months of 1997 were reduced
by  approximately  12% as a result of the strength of the US dollar  compared to
the Dutch guilder.

During the second  quarter  and first six months of 1997,  two of the  Company's
major  customers  accounted  for 56% and 33% and 59% and 31%,  respectively,  of
revenues.


                                       -8-

<PAGE>
Results of Operations (continued)
Cost of Services and Products

Cost of  services  as a  percentage  of service  revenues  was 36% in the second
quarter and first six months of 1997 compared to 40% and 41%,  respectively,  in
the same  periods last year.  The decline in costs as a  percentage  of revenues
results  primarily  from (i) a shift in revenue mix toward  services with higher
gross margins; (ii) operating  efficiencies resulting from increased volume; and
(iii) an  increase  in fees  charged  to the  Company's  customers  for  certain
allograft processing services.

Cost of  products as a  percentage  of product  revenues  was 73% and 74% in the
second quarter and first six months of 1997,  respectively,  compared to 86% and
79% in the same  periods  last year.  The  decline in costs as a  percentage  of
revenues  results  primarily  from a shift in product mix toward  products  with
higher gross margins.


Marketing, General and Administrative

Marketing,  general and administrative expenses increased $847,000 or 28% in the
second quarter and  $1,489,000 or 24% in the first six months of 1997,  compared
to the same periods last year.  The increases  were  primarily  attributable  to
expanded  marketing  activities  associated with the continued  expansion of the
business and increased  administrative  costs,  principally outside professional
services.


Research and Development

Research and development  expenses decreased  $232,000 and $357,000,  or 21% and
16%, in the second quarter and first six months of 1997, respectively,  compared
to the same  periods  last  year.  The  decreases  result  principally  from the
discontinuance  of the Company's  PolyActive  polymer  research and  development
program in the fourth quarter of 1996.


Other Income, net

Interest  income  increased  $33,000 and $60,000 in the second quarter and first
six months of 1997, respectively, compared to the same periods in the prior year
due to a higher  level of  invested  funds and a higher  average  return on such
funds.

Interest expense  decreased  $30,000 and $50,000 in the second quarter and first
six months of 1997, respectively,  compared to the same period in the prior year
as a result of lower outstanding debt and obligations under capital leases.


                                       -9-

<PAGE>

Provision for Income Taxes

The  Company's  effective  income tax rate declined to 36% and 41% in the second
quarter and first six months of 1997, respectively, from 71% and 72% in the same
periods last year.  The high effective  income tax rate in 1996 was  principally
due to foreign  losses for which no current tax  benefits  were  available.  The
Company's  effective  income tax rate is expected  to remain near the  six-month
rate of 41% for the remainder of 1997.


Liquidity and Capital Resources

At June 30,  1997,  the Company  had cash and cash  equivalents  and  short-term
investments of $11,398,000  compared to $9,277,000 at December 31, 1996. Working
capital  increased  by  $2,326,000  from  $12,273,000  at  December  31, 1996 to
$14,599,000 at June 30, 1997.

Cash flow from  operating  activities  increased to  $3,891,000 in the first six
months of 1997 from  $2,327,000 in the first six months of 1996  principally due
to the  increase in net income and  decreases  in prepaid  expenses and accounts
receivable. Capital expenditures increased to $1,585,000 in the first six months
of 1997 from  $1,200,000 in the same period in 1996 as the Company  continues to
invest in  facilities  and  equipment  needed for  current  and future  business
requirements, principally allograft tissue processing capacity.

The Company has a loan and security  agreement with a US bank which provides for
borrowings of up to $3,000,000  under a revolving  line of credit and $4,000,000
under an equipment line of credit. At June 30, 1997,  $1,024,000 was outstanding
under the  equipment  line of credit  and there were no  borrowings  outstanding
under the revolving line of credit.

The  Company  also has a line of credit  with a Dutch  bank which  provides  for
borrowings  of  up  to  5,000,000  Dutch  Guilders  ("dfl"),   or  approximately
$2,546,000 at the June 30, 1997 exchange  rate.  Analysis of the Company's  cash
position and  anticipated  cash flow  indicated that it most likely would not be
necessary to utilize a significant portion of the line of credit and, therefore,
the Company has agreed to temporarily  limit its borrowings,  if any, to no more
than  3,000,000 dfl, or  approximately  $1,527,000 at the June 30, 1997 exchange
rate. Additionally, in connection with the Leiden facility lease, the Company is
required  to  maintain a  declining  bank  guarantee  which  reduced  the amount
available for  borrowings to 2,605,000 dfl, or  approximately  $1,326,000 at the
June 30, 1997 exchange rate.  There were no borrowings under this credit line as
of June 30, 1997.

The Company believes that its cash,  short-term  investments and available lines
of  credit,  together  with  anticipated  cash  flow  from  operations,  will be
sufficient to meet its near-term requirements. From time to time the Company may
seek additional funds through equity or debt financing. However, there can be no
assurances  that such additional  funds will be available to the Company,  or if
available, that such funds will be available on terms favorable to the Company.


                                      -10-

<PAGE>


ITEM 3.  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

           Not Applicable



PART II.         OTHER INFORMATION

ITEM 1. LEGAL PROCEEDINGS


1. Orthopaedic Bone Screw Products Liability Litigation

As of August 8, 1997,  the Company  was aware of being  named as a defendant  in
approximately 34 cases based in products  liability in connection with allegedly
defective spinal devices as described in the Company's  Quarterly Report on Form
10-Q for the quarter ended March 31, 1997.  This  represents a decrease from the
79 cases previously  reported in such Quarterly  Report. Of these cases, 32 have
been consolidated with other similar actions for coordinated  proceedings in the
Eastern District of Pennsylvania  under the caption In re: Orthopedic Bone Screw
Products Liability Litigation, MDL Dkt. 1014. The remaining cases are pending in
the state courts of Ohio and Pennsylvania.



2. Kehr et al. v. Musculoskeletal Transplant Foundation and Osteotech, Inc.

The plaintiffs in this action agreed to dismiss this action with  prejudice.  On
May 19,  1997,  the court  approved of and entered a  stipulation  and order for
dismissal.


3. Patent Litigation

The  Company  has  initiated  an  infringement  action  against  LifeNet,   Inc.
("LifeNet")  in the  District  Court of New Jersey  alleging  that  LifeNet  has
infringed US Patent Nos.  5,333,626 and 5,513,662 owned by the Company.  LifeNet
has answered and filed a  counterclaim  that such patents are not  infringed and
are invalid and unenforceable.

LifeNet  Research  Foundation,  an affiliate  of LifeNet,  has brought an action
against the Company in the District Court of Virginia alleging that such patents
are  invalid,  unenforceable  and not  infringed.  The  Company  has denied such
allegations  and is  attempting  to have  the two  actions  consolidated  in New
Jersey. LifeNet is attempting to have the two actions consolidated in Virginia.


                                      -11-

<PAGE>
ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

          (a)  An annual meeting of stockholders was held on June 5, 1997.

          (b)  The  directors  elected at the annual  meeting to serve a term of
               one year or until the next annual meeting of  stockholders  were:
               Richard W. Bauer,  Kenneth P. Fallon,  III,  Michael J. Jeffries,
               Donald D. Johnston,  John Phillip  Kostuik,  M.D.,  FRCS(C),  and
               Stephen J.  Sogin,  Ph.D.  They  constitute  the entire  board of
               directors of the Company.

          (c)  The matters  voted upon at the annual  meeting and the results of
               the voting are set forth below.

               i)     With  respect to a proposal  to ratify  amendments  to the
                      Company's 1991  Independent  Directors' Stock Option Plan,
                      as amended (the "Plan"),  effective as of July 1, 1997, to
                      (i) decrease the number of options  granted to Independent
                      Directors  (as  defined in the Plan)  upon  their  initial
                      election  to the Board of  Directors  (the  "Board")  from
                      20,000 to 10,000 and upon their  re-election  to the Board
                      from 10,000 to 7,500,  (ii) alter the vesting  schedule of
                      options  granted  under  the Plan from 25% per year over a
                      four (4) year period  commencing on the first  anniversary
                      of  the  date  of  grant  to  100%  vested  on  the  first
                      anniversary  of the date of grant,  (iii)  provide for the
                      options  granted  under  the Plan to be  exercisable  once
                      vested through the tenth  anniversary of the date of grant
                      rather  than the  current  five (5) year  exercise  period
                      commencing on the respective vesting date for each tranche
                      of shares,  (iv) alter the time period when options expire
                      upon an Independent  Director's  departure from the Board,
                      for any reason except removal for cause,  from ninety (90)
                      days to the lesser of five (5) years from the date of such
                      departure or the original  term  remaining for exercise of
                      such  options,  (v) provide for the  cashless  exercise of
                      options  through  the  delivery  of  stock  issuable  upon
                      exercise  of  such  options,  and  (vi)  provide  for  the
                      accelerated vesting of options upon a change of control of
                      the Company,  the  stockholders  voted 5,805,795 shares in
                      favor,  374,131  against  and  22,510  abstained.   Broker
                      non-votes were 686,662.

                    This proposal received the vote required by Delaware General
                    Corporation  Law  ("DGCL")  and the  Company's  by-laws  for
                    approval  (i.e.  affirmative  vote  of  a  majority  of  the
                    outstanding  shares  present at the meeting,  by proxy or in
                    person, and entitled to vote at the annual meeting).


                                      -12-


<PAGE>

ITEM 4.(c)  (continued)


               (i)  With  respect to the  election of  Directors of the Company,
                    the persons  named below  received the  following  number of
                    votes:

                Director                          For              Withheld
 ---------------------------------------    ----------------    ---------------
 Richard W. Bauer                              6,808,295            80,803
 Kenneth P. Fallon, III                        6,808,295            80,803
 Michael J. Jeffries                           6,808,195            80,903
 Donald D. Johnston                            6,808,195            80,903
 John Phillip Kostuik, M.D.                    6,808,195            80,903
 Stephen J. Sogin, Ph.D.                       6,808,195            80,903


               (ii)   With  respect to a proposal  to ratify  the  selection  of
                      Coopers  & Lybrand  L.L.P.  as the  Company's  independent
                      auditors for the fiscal year ending December 31, 1997; the
                      stockholders   voted  6,874,349  shares  in  favor,  6,723
                      against and 8,026  abstained.  Broker  non-votes  were not
                      applicable.  This  proposal  received the vote required by
                      DGCL  and  the  Company's   by-laws  for  approval   (i.e.
                      affirmative  vote of a majority of the outstanding  shares
                      present  at  the  meeting,  by  proxy  or in  person,  and
                      entitled to vote at the annual meeting).


ITEM 6.  EXHIBITS AND REPORTS ON FORM 8-K

(a)      Exhibits (numbered in accordance with Item 601 of
                     Regulation S-K)

Exhibit                                                                Page
Number            Description                                         Number
- ----------------------------------------------------------------------------

10.30             Fourth Amendment to Loan and Security Agreement
                  between the Company and Summit Bank
                  dated July 28, 1997                                   E-1

10.31             Third Restated Equipment Promissory Note
                  between the Company and Summit Bank
                  dated July 28, 1997                                   E-11



                                      -13-

<PAGE>

Item 6. (a)       Exhibits (continued)


  Exhibit                                                                Page
  Number            Description                                         Number
  ------            -----------                                         ------


  10.32             Second Restated Revolving Loan Promissory
                    Note between the Company and Summit Bank
                    dated July 28, 1997                                   E-16

  10.33             License & Option Agreement between HC Implants
                    BV and Matrix Medical Holding BV
                    dated June 6, 1997                                    E-20

  11.1              Computation of Primary Net Income Per Share           E-41

  11.2              Computation of Fully Diluted Net Income
                     Per Share                                            E-42

  27.0              Financial Data Schedule                               E-43



       (b)    Reports on Form 8-K

              On April 11, 1997, the Company filed with the Commission a Current
              Report  on Form 8-K  dated  April 1, 1997  (the  "Form  8-K"),  to
              announce  that it entered into an agreement  with  Musculoskeletal
              Transplant  Foundation  ("MTF") whereby the Company is to serve as
              the  exclusive  processor  of human  bone and  related  connective
              tissue for  transplantation  received  from donors and procured by
              MTF  for a five  year  period,  with an  option  to  renew  for an
              additional five year period.

              Additionally,  in the same Form 8-K, the Company announced that it
              had obtained a consent  injunction in its suit against  Biosystems
              of  New  England,  Inc.  ("Biosystems").   The  Company  had  sued
              Biosystems,  a former  sales  agent for the  Company's  Grafton(R)
              Demineralized Bone Matrix allograft tissue form, for breaching the
              non-compete  and other  provisions  of the Sales Agency  Agreement
              ("Sales  Agreement").  As part of the  injunction,  Biosystems has
              agreed  to fully  comply  with the  terms  and  conditions  of the
              non-compete  clause of the sales  Agreement  and the  Company  has
              agreed to allow  Biosystems to market one form of allograft tissue
              processed  by another  tissue  bank,  in  exchange  for  extending
              Biosystems'  non-compete obligation from July 1997 to December 31,
              1997.

                                      -14-

<PAGE>

                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.

                                                                 Osteotech, Inc.
                                                                    (Registrant)



Date:    August 8, 1997             By:              /s/ RICHARD W. BAUER
                                                     --------------------
                                                         Richard W. Bauer
                                                         President, Chief
                                                         Executive Officer



Date:    August 8, 1997             By:              /s/ MICHAEL J. JEFFRIES
                                                     -----------------------
                                                      Michael J. Jeffries
                                                      Executive Vice President
                                                      Chief Operating Officer
                                                      Chief Financial Officer



                                      -15-




                                                                   EXHIBIT 10.30


                 FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT


         This Fourth  Amendment  to Loan and  Security  Agreement is dated as of
July 28, 1997 (this "Amendment") by and among:

Summit Bank,  f/k/a United Jersey Bank, f/k/a United Jersey  Bank/Central,  N.A.
(the "Bank"), a New Jersey banking corporation having an address at 301 Carnegie
Center, CN 5316, Princeton, New Jersey 08543-5316; and,

Osteotech,  Inc. (the "Borrower"),  a Delaware  corporation having its principal
place of business at 51 James Way, Eatontown, New Jersey 07724.

                                    RECITALS:

         WHEREAS,  pursuant to the terms of a Loan and Security  Agreement dated
May 27,  1993 (the "Loan  Agreement"),  the Bank  provided a  $4,000,000  credit
facility  (the  "Credit  Facility")  to the  Borrower,  including  a  $2,000,000
Revolving Loan and a $2,000,000 Equipment Loan; and,

         WHEREAS,  pursuant  to a  First  Amendment  to the  Loan  and  Security
Agreement  dated July 14, 1994 (the "First  Amendment"),  the Bank,  among other
things,  extended the term of the Credit  Facility to May 31, 1995 and increased
the amount to the Credit Facility to $6,000,000.00; and,

         WHEREAS,  pursuant  to a Second  Amendment  to the  Loan  and  Security
Agreement dated June 30, 1995 (the "Second  Amendment"),  the Bank,  among other
things, extended the term of the Credit Facility to May 31, 1996; and,

         WHEREAS,  pursuant  to a  Third  Amendment  to the  Loan  and  Security
Agreement  dated May 31, 1996 (the  "Third  Amendment"),  the Bank,  among other
things,  extended the term of the Credit  Facility to May 31, 1997 and increased
the amount the Credit Facility to $7,000,000.00; and

         WHEREAS,  the term of the Credit  Facility  expired on May 31, 1997 and
the Borrower  has  requested  to extend the term of the Credit  Facility,  among
other  things,  and the  Bank has  agreed  to do so  subject  to the  terms  and
conditions set forth herein.


                                      E-1

<PAGE>

         NOW  THEREFORE,  in  consideration  of  the  recitals  and  the  mutual
covenants  contained herein and in the other  agreements  executed in connection
with the Credit Facility, the parties hereto agree as follows:1. Notwithstanding
anything to the contrary contained in the Loan Agreement, the Notes or any other
Fundamental  Document as amended by the First  Amendment,  Second  Amendment  or
Third  Amendment  (the  "Amended  Fundamental  Documents"),  the  terms  of this
Amendment  shall control.  All  capitalized  terms used herein and not otherwise
defined herein shall have the meanings  ascribed to them pursuant to the Amended
Fundamental Documents.

2.       The Loan Agreement is hereby amended as follows:

     (a)  The  following  definitions  are hereby  amended  and  restated in its
          entirety to read as follows:

               "Loan Termination Date" means May 31, 1998.

                  "Notes" means,  collectively,  the promissory note made by the
                  Borrower in favor of the Bank,  in a  principal  amount not to
                  exceed Four Million  Dollars  ($4,000,000.00)  evidencing  the
                  Borrower's   Obligations  to  the  Bank  in  connection   with
                  Equipment  Advances  and  the  promissory  note  made  by  the
                  Borrower in favor of the Bank,  in a  principal  amount not to
                  exceed Three Million  Dollars  ($3,000,000.00)  evidencing the
                  Borrower's   Obligations  to  the  Bank  in  connection   with
                  Revolving Loan Advances.

         (b)      The following definitions are added:

                  "Base  Rate  Advance"  means an  Advance  which  the  Borrower
                  requests to be made as an Advance  which will accrue  interest
                  at the Base Rate in accordance  with the provisions of Section
                  2.06 hereof.

                    "Equipment Advance Application" has the meaning set forth in
                    Section 2.03(a).

                  "Eurodollar  Advance"  means an  Advance  which  the  Borrower
                  requests to be made as an Advance  which will accrue  interest
                  at the  Eurodollar  Rate or which is  reborrowed as an Advance
                  with a Eurodollar  Rate, in accordance  with the provisions of
                  Section 2.06 hereof.

                  "Eurodollar   Advance  Period"  means,   for  each  Eurodollar
                  Advance,  each one, two, or three month period, as selected by
                  the Borrower pursuant to Section 2.06 hereof, during which the
                  applicable    Eurodollar   Rate   shall   remain    unchanged.
                  Notwithstanding the foregoing, however:

                                      E-2
<PAGE>
                  (i) any  applicable  Eurodollar  Advance  Period  which  would
                  otherwise  end on a day which is not a  Business  Day shall be
                  extended  to the next  succeeding  Business  Day,  unless such
                  Business Day falls in another  calendar  month,  in which case
                  such  Eurodollar  Advance  Period  shall end on the  preceding
                  Business Day; (ii) any  applicable  Eurodollar  Advance Period
                  which  begins  on a day  for  which  there  is no  numerically
                  corresponding  day in the  calendar  month  during  which such
                  Eurodollar  Advance  Period is to end shall (subject to clause
                  (i) above)  end on the last day of such  calendar  month;  and
                  (iii) no  Eurodollar  Advance  Period shall extend  beyond the
                  Loan  Termination Date or such earlier date as would interfere
                  with the repayment obligations of the Borrower under Section 2
                  hereof.  "Eurodollar Basis" means, a simple per annum interest
                  rate equal to the quotient of (i) the Eurodollar  Rate divided
                  by (ii) one minus the Eurodollar Reserve  Percentage,  if any,
                  stated as a decimal.  The  Eurodollar  Basis  shall be rounded
                  upward to the nearest  one  sixteenth  of one percent  (1/16%)
                  and,  once  determined,  shall  remain  unchanged  during  the
                  applicable  Eurodollar  Advance Period,  except for changes to
                  reflect adjustments in the Eurodollar Reserve Percentage.

               "Eurodollar Margin" has the meaning set forth in Section 2.06(b).

                  "Eurodollar Rate" means for any Eurodollar Advance Period, the
                  average  (rounded  upward to the nearest one  sixteenth of one
                  percent  (1/16%))  of the  interest  rates  per annum at which
                  deposits in United States dollars for such Eurodollar  Advance
                  Period  are  offered to prime  banks in the  London  interbank
                  market  as   reported   on   Telerate   Screen  page  3750  at
                  approximately  11:00 a.m. (Eastern Time) two (2) Business Days
                  before the first day of such Eurodollar  Advance Period, in an
                  amount approximately equal to the principal amount of, and for
                  a length of time approximately equal to the Eurodollar Advance
                  Period for, the Eurodollar Advance sought by the Borrower.  If
                  such rate is not so  reported,  then such rate as  reported by
                  any other  internationally  recognized reporting service shall
                  be  selected  by the  Bank or,  if no such  other  service  is
                  available,  such rate shall be determined by the Bank based on
                  rate information furnished to it by two or more banks selected
                  by it which participate in the market for such deposits.

                                      E-3

<PAGE>
                  "Eurodollar  Reserve Percentage" means the percentage which is
                  in effect from time to time under Regulation D of the Board of
                  Governors of the Federal  Reserve  System,  as such regulation
                  may be  amended  from  time to time,  as the  maximum  reserve
                  requirement    applicable   with   respect   to   Eurocurrency
                  Liabilities (as that term is defined in Regulation D), whether
                  or not the Bank has any  Eurocurrency  Liabilities  subject to
                  such reserve  requirement at that time.  The Eurodollar  Basis
                  for  any  Eurodollar  Advance  shall  be  adjusted  as of  the
                  effective date by the same effective basis point change of any
                  change in the Eurodollar  Reserve  Percentage.  "Payment Date"
                  means the last day of each  Eurodollar  Advance  Period  for a
                  Eurodollar Advance.

     (c)  Section  2.02(b) is hereby  amended and  restated  in its  entirety as
          follows:

                  (b) Each  Revolving  Loan Advance  shall be made on telephonic
                  notice  given by the  Borrower  to the Bank and  confirmed  by
                  telefax from the Borrower and received by the Bank before 3:00
                  p.m.  EST at telefax  number  741-0341.  Each such notice of a
                  Revolving  Loan  Advance (a "Notice  of  Advance")  shall be a
                  signed  writing by the  Borrower  specifying  therein  (i) the
                  requested  Advance Date, (ii) the amount of such advance,  and
                  (iii)  whether  the  Advance  is  a  Base  Rate  Advance  or a
                  Eurodollar Advance, as defined in Section 2.06. Such Notice of
                  Advance  must be  received  by the Bank not later  than  11:00
                  a.m.,  EST, on the second  Business  Day prior to the proposed
                  Advance Date.

     (d)  Sections  2.06 is hereby  amended and  restated  in their  entirety as
          follows:

                  Section 2.06.     Interest Rates.

               (a)  Choice of Interest Rate. Any Advance shall, at the option of
                    the  Borrower and  pursuant to the terms and  conditions  of
                    this  Agreement,  be made either as a Base Rate Advance or a
                    Eurodollar Advance.


                                      E-4

<PAGE>

               (b)  Interest Rate on Revolving Loan Advances. All amounts due to
                    the Bank in connection with the Revolving Loan Advance shall
                    bear  interest  during each calendar  month  pursuant to the
                    Borrower's   Notice  of  Advance  either  at  a  fluctuating
                    interest  rate per annum equal at all times to the Base Rate
                    in  effect  from time to time,  or two  hundred  (200)  base
                    points greater than the Eurodollar  Rate in effect from time
                    to time ("Eurodollar Margin").

               (c)  Interest Rate on Equipment Advances.  All amounts due to the
                    Bank  in  connection  with  Equipment  Advances  shall  bear
                    interest   during  each  calendar   month  pursuant  to  the
                    Borrower's  Equipment  Advance  Application at a fluctuating
                    interest  rate per annum equal at all times to the Base Rate
                    in effect from time to time or the Eurodollar Margin.

               (d)  Changes in Interest Rates.  Each change in such  fluctuating
                    interest   rates   referred   to  above  shall  take  effect
                    simultaneously  with the  corresponding  change in such Base
                    Rate or  Eurodollar  Rate  without  notice to the  Borrower.
                    Interest  shall  be  calculated  on a daily  basis  upon the
                    unpaid balance with each day representing 1/360th of a year.
          
               (e) Eurodollar Advances.

                                    (i)   Initial  and   Subsequent   Eurodollar
                  Advances.  The Bank, whose  determination shall be conclusive,
                  shall  determine the  Eurodollar  Basis as of the Business Day
                  prior to the date of the requested  Advance and shall promptly
                  notify  the  Borrower  of the  same  and  the  Borrower  shall
                  promptly confirm in writing receipt of such notification.  The
                  Eurodollar Advance Period for each Eurodollar Advance shall in
                  all events be either thirty, sixty or ninety days, as selected
                  by the Borrower pursuant to the Notice of Advance or Equipment
                  Advance Application ("Eurodollar Advance Period").

                                    (ii)    Procedures    After   Repayment   of
                  Eurodollar  Advance. At least three (3) Business Days prior to
                  each Payment Date for a Eurodollar Advance, the Borrower shall
                  give the  Bank  written  notice  specifying  whether  all or a
                  portion of any Eurodollar  Advance  outstanding on the Payment
                  Date (a) is to be repaid  and then  reborrowed  in whole or in
                  part as a new  Eurodollar  Advance,  in which case such notice
                  shall also  specify the  Eurodollar  Advance  Period which the
                  Borrower shall have selected for such

                                      E-5

<PAGE>
                  new  Eurodollar  Advance,   (b)  is  to  be  repaid  and  then
                  reborrowed in whole or in part as a Base Rate Advance,  or (c)
                  is to be repaid and not  reborrowed.  Upon such  Payment  Date
                  such  Eurodollar  Advance  will,  subject  to  the  provisions
                  hereof, be so repaid and, as applicable, reborrowed.

                                    (iii) Limitations as to Eurodollar Advances.
                  Requests for  Eurodollar  Advances may be made daily (but only
                  once  a  day)  provided  the  Borrower  satisfies  all  notice
                  requirements as provided for herein.

                                    (iv) Reimbursement.  Whenever the Bank shall
                  actually  incur any losses or actual  expenses  in  connection
                  with (i)  failure by the  Borrower  to borrow  any  Eurodollar
                  Advance  after having given notice of its  intention to borrow
                  (whether  by reason of the  election  of the  Borrower  not to
                  proceed or the non-fulfilment of any conditions precedent), or
                  (ii) prepayment of any Eurodollar Advance in whole or in part,
                  for any reason,  the Borrower  agrees to pay to the Bank, upon
                  the Bank's demand, an amount sufficient to compensate the Bank
                  for  all  such  losses  and  actual  expenses  excluding  lost
                  profits. Bank's good faith determination of the amount of such
                  losses and actual  expenses,  absent manifest error,  shall be
                  binding and  conclusive.  The Bank shall provide a copy of the
                  determination  of  such  amount  to the  Borrower  showing  in
                  reasonable detail the calculation of the amount thereof.

                  (f)      General Provisions as to Eurodollar Advances.

               (i)  Unavailability.  Notwithstanding  anything  contained herein
which  may be  construed  to the  contrary,  if  with  respect  to any  proposed
Eurodollar  Advance for any Eurodollar  Advance Period, the Bank determines that
deposits in dollars (in the applicable amount) are not being offered to the Bank
in the  relevant  market  for such  Eurodollar  Advance  Period,  the Bank shall
forthwith give notice thereof to the Borrower, whereupon until the Bank notifies
the  Borrower  that the  circumstances  giving rise to such  situation no longer
exist,  the  obligations  of the  Bank  to make  Eurodollar  Advances  shall  be
suspended.

               (ii) Illegality.  If any applicable law, rule, or regulation,  or
any  change  therein,  or any  interpretation  or  change in  interpretation  or
administration  thereof  by  any  governmental   authority,   central  bank,  or
comparable agency charged with the interpretation or administration  thereof, or
compliance  by Bank with any  request or  directive  (whether  or not having the
force of law) of any such authority,  central bank, or comparable agency,  shall
make it unlawful

                                      E-6

<PAGE>

or impossible for Bank to make, maintain, or fund its Eurodollar Advances,  Bank
shall  forthwith  give notice to the  Borrower.  Before giving any notice to the
Borrower pursuant to this Section 2.06(f),  the Bank shall designate a different
lending  office if such  designation  will avoid the need for giving such notice
and will not,  in the  reasonable  judgment  of Bank,  be  otherwise  materially
disadvantageous to Bank. Upon receipt of such notice,  notwithstanding  anything
contained  in  Section  2,  the  Borrower  shall  repay  Bank in full  the  then
outstanding principal amount of each affected Eurodollar Advance,  together with
accrued  interest  thereon,  either  (a) on the  last  day of the  then  current
Eurodollar  Advance Period applicable to such Eurodollar Advance to such day, or
(b)  immediately  if Bank may not lawfully  continue to fund and  maintain  such
Eurodollar  Advance to such day; provided,  however,  that  notwithstanding  any
provision contained in this Agreement to the contrary, the Borrower shall not be
required  to  compensate  Bank for any  losses,  including  any loss or expenses
incurred by reason of the  liquidation,  reemployment of deposits or other funds
acquired to obtain the  Eurodollar  Advance,  incurred as a  consequence  of any
required  conversion  of  a  Eurodollar  Advance  to  a  Base  Rate  Advance  as
hereinafter  provided,  as a result of the events described in this Section 2.6.
Concurrently   with  repaying  each   affected   Eurodollar   Advance  of  Bank,
notwithstanding  anything  contained in Section 2, the  Borrower  shall borrow a
Base Rate  Advance  from Bank,  and Bank shall make such loan in an amount  such
that the outstanding  principal  amount of the Note held by Bank shall equal the
outstanding principal amount of such Note immediately prior to such repayment.

               (iii)   Increased Costs.

          (1) If, after the date hereof, any applicable law, rule or regulation,
     or any change therein, or any interpretation or change in interpretation or
     administration  thereof by any  governmental  authority,  central  bank, or
     comparable agency charged with the interpretation or administration thereof
     or compliance by Bank with any request or directive  (whether or not having
     any such authority), shall:

     (A) subject  Bank to any tax,  duty,  or other  charge with  respect to its
obligations to make Eurodollar  Advances,  or shall change the basis of taxation
of payments to Bank of the principal of or interest on its  Eurodollar  Advances
or in respect of any other  amounts due under this  Agreement  in respect of its
Eurodollar  Advances or its obligation to make Eurodollar  Advances  (except for
taxes  imposed  upon or measured by net income or  alternative  minimum  taxable
income or taxable  assets in lieu of income imposed by the United States and the
jurisdiction in which Bank's principal executive office is located); or

                                      E-7

<PAGE>
     (B) impose,  modify, or deem applicable with respect to the making, funding
or  maintaining  any  Advance  hereunder,   any  reserve   (including,   without
limitation, any imposed by the Board of Governors of the Federal Reserve System,
but  excluding  any included in an applicable  Eurodollar  Reserve  Percentage),
special deposit, capital adequacy, assessment, or other requirement or condition
against assets of, deposits with or for the account of, or commitments or credit
extended by Bank, or shall impose on Bank or the Eurodollar  interbank borrowing
market or any other  condition  affecting its obligation to make such Eurodollar
Advances; and the result of any of the foregoing is to increase the cost to Bank
of making or maintaining any such Eurodollar  Advances,  or to reduce the amount
of any sum  received or  receivable  by Bank under this  Agreement  or under its
Notes  with  respect  thereto,  and such  increase  is not  given  effect in the
determination  of the  Eurodollar  Rate then, on the earlier of thirty (30) days
after written demand by Bank or the Loan  Termination  Date, the Borrower agrees
to pay to  Bank  such  additional  amount  or  amounts  as  Bank  determines  is
attributable to making, funding and maintaining its Eurodollar Advances provided
that Bank  provides  notice to the Borrower of such amount within 90 days of the
date of the actual  knowledge of Bank of the occurrence of the event giving rise
to such cost.  Bank will  promptly  notify the Borrower of any event of which it
has  knowledge,  occurring  after the date  hereof,  which will  entitle Bank to
compensation pursuant to this Section 2.6 and will designate a different lending
office if such  designation  will  avoid the need for,  or reduce the amount of,
such compensation and will not, in the reasonable judgment of Bank, be otherwise
materially disadvantageous to Bank.

          (2) A  certificate  of Bank claiming  compensation  under this Section
     2.6(f) and setting forth the additional  amount or amounts to be paid to it
     hereunder and  calculations  therefor shall be conclusive in the absence of
     manifest  error.  In determining  such amount,  Bank may use any reasonable
     averaging and  attribution  methods and shall calculate such sums in a fair
     and  reasonable  manner.  If Bank demands  compensation  under this Section
     2.6(f), the Borrower may at any time, upon at least five (5) Business Days'
     prior  notice  to  Bank,  prepay  in full  the  then  outstanding  affected
     Eurodollar  Advances of Bank, together with accrued interest thereon to the
     date of prepayment.  Concurrently  with prepaying such Eurodollar  Advances
     the Borrower shall borrow a Base Rate Advance,  or a Eurodollar Advance not
     so affected,  from Bank, and Bank shall make such Advance in an amount such
     that the outstanding principal amount of the Notes held by Bank shall equal
     the outstanding  principal amount of such Notes  immediately  prior to such
     prepayment.


                                      E-8

<PAGE>
               (iv) Effect On Other Advances.  If notice has been given pursuant
          to Section  2.6(f)(iii),  suspending  the obligation of Bank to make a
          Eurodollar  Advance,  or requiring  Eurodollar  Advances of Bank to be
          repaid or prepaid,  then,  unless and until Bank notifies the Borrower
          that the circumstances  giving rise to such repayment no longer apply,
          all  Loans  which  would  otherwise  be made  by  Bank to the  type of
          Eurodollar Advances affected shall, at the option of the Borrower,  be
          made instead as Base Rate Advances.

           (g) Base Rate Advances.

     (i) Procedure to Convert Base Rate Advance to Eurodollar Advance.  Borrower
may at any time or from  time to time,  so long as no Event of  Default  exists,
convert a Base Rate  Advance to a  Eurodollar  Advance  upon at least  three (3)
Business Days written notice to the Bank.  Such written notice shall specify (A)
the  specific  amount of the Base Rate  Advance  which  will be  converted  to a
Eurodollar  Advance,  (B) the applicable  Eurodollar Advance Period, and (C) the
date of conversion  of the Base Rate Advance to a Eurodollar  Advance (such date
of conversion  shall be at least three (3) days  following the written notice by
Borrower pursuant to this subsection).

3.  Except as  expressly  otherwise  provided  herein,  the terms of the Amended
Fundamental Documents shall remain in full force and effect and are incorporated
herein  by  reference.  In the  event of a  conflict  between  the terms of this
Amendment  and  any  other  Amended  Fundamental  Document,  the  terms  of this
Amendment shall control.

4. The Borrower acknowledges that the Bank has no obligation to make any further
amendments to the Amended Fundamental  Documents or any other agreement executed
in  connection  therewith.  The  Borrower  further  acknowledges  that it has no
defenses to any of its  obligations to the Bank and represents  that no Event of
Default has occurred.

5.  The  Borrower  shall  be  liable  for  all  reasonable  costs  and  expenses
(comprising  legal fees and  disbursements)  incurred by the Bank in  connection
with this  Amendment,  and shall promptly pay or reimburse the Bank for all such
costs.

6. This Amendment  shall be construed in accordance  with, and shall be governed
by, the laws of the State of New Jersey,  without reference to the choice of law
doctrine of such state. Except as otherwise expressly set forth herein,  nothing
in this  Amendment  shall be construed as a waiver or release by the Bank of any
rights or remedies of the Bank.  This Amendment  shall be binding upon and inure
to the  benefit  of the  parties  hereto  and their  respective  successors  and
assigns.

                                      E-9

<PAGE>

IN WITNESS  WHEREOF,  the  undersigned  have set their hands and seals or caused
this Fourth  Amendment  to Loan and  Security  Agreement to be executed by their
proper  corporate  officers  and sealed with their seal  effective as of May 31,
1997.


ATTEST:                                           OSTEOTECH, INC.


/s/ STEVEN SOBIESKI                      BY:  /s/ MICHAEL J. JEFFRIES
- -------------------                           -----------------------
NAME:  Steven Sobieski                    Michael J. Jeffries, Exec. V.P.
       Vice President Finance             COO & CFO


ATTEST:                                           SUMMIT BANK


/s/ JOHN F. GANNING                      By:  /s/ DAVID M. NILSEN
- -------------------                            -------------------
Name:  John F. Ganning             Name:     David M. Nilsen
        Vice President                       Title:  Vice President


                                      E-10




                                                                   EXHIBIT 10.31


                                   SUMMIT BANK
                               301 Carnegie Center
                                  P.O. Box 2066
                        Princeton, New Jersey 08543-2066

                                 THIRD RESTATED
                            EQUIPMENT PROMISSORY NOTE

$4,000,000                                                Middletown, New Jersey
                                                            Date:  July 28, 1997

      FOR VALUE RECEIVED,  the undersigned  ("Borrower")  promises to pay to the
order  of  Summit  Bank,   f/k/a  United   Jersey  Bank,   f/k/a  United  Jersey
Bank/Central,  N.A.  ("Bank"),  at its executive offices at 301 Carnegie Center,
Princeton, New Jersey 08543, or at such other place as the Bank may from time to
time  designate by notice to the  Borrower,  the  principal  sum of FOUR MILLION
DOLLARS  ($4,000,000.00),  or so much  thereof as may be advanced  as  Equipment
Advances  pursuant to the Loan and Security  Agreement  between the Bank and the
Borrower  dated May 27, 1993, as amended (the  "Agreement"),  in lawful money of
the United States of America with interest, calculated on the basis of a 360 day
year, on the unpaid  balance from the date of this  Promissory  Note ("Note") at
the rates set forth below until paid.  Any  capitalized  terms used herein shall
have the meanings ascribed to them in the Agreement.

      All  amounts due to the Bank in  connection  with each  Equipment  Advance
shall bear  interest  during each  calendar  month  pursuant  to the  Borrower's
Equipment Advance Application at a fluctuating  interest rate per annum equal at
all times to the Bank's  Base Rate in effect  from time to time,  or two hundred
(200) basis points greater than the Eurodollar  Rate in effect from time to time
until the Loan Termination Date. Each change in such fluctuating rate shall take
effect  simultaneously  with  the  corresponding  change  in such  Base  Rate or
Eurodollar  Rate,  when  applicable,  without  notice to the  undersigned or any
endorser,  surety or guarantor. Any such change shall not affect or alter any of
the other terms and conditions of this Note. All  computations of interest shall
be  calculated  on  a  daily  basis  upon  the  unpaid  balance  with  each  day
representing  1/360th of a year. The undersigned  shall make monthly payments of
interest,  which  payments  shall be due no later  than  the  first  day of each
calendar month.

      The Borrower  shall make  monthly  payments of principal of amounts due in
connection  with  Equipment  Advances until the earlier of the date on which all
amounts due in connection with the Equipment  Advances have been paid in full or
the Loan  Termination  Date on which date all  amounts  due  hereunder  shall be
immediately due and payable. Such payments shall be equal to 1/48th of the total
amount of principal due in connection  with Equipment  Advances and shall be due
on the first day of each month.

                                      E-11
<PAGE>

      The terms,  covenants  and  conditions  of the Agreement are hereby made a
part of this Note,  to the extent and with the same  effect as if more fully set
forth  herein and the  Borrower  hereby  covenants  and promises to abide by and
comply with each and every term,  covenant and  condition set forth in this Note
and in the Agreement.

      Notwithstanding  the  foregoing,  and  in  addition  to the  terms  of the
Agreement, the unpaid balance of the principal amount owing hereunder,  together
with interest thereon, shall immediately become due and payable, at the election
of the holder hereof, in the event of:

     (a)  Failure to make any payment of principal or interest when due;

     (b)  Failure to observe or perform any term,  covenant or condition of this
          Note or the Agreement with respect to the payment of money; and

     (c)  Any Event of Default as defined in the Agreement.

      For each amount  payable by the  Borrower to the Bank under this Note that
is not paid by the tenth (10th) day  following the date on which such payment is
due (whether at the Loan Termination  Date, by acceleration or otherwise) and to
the extent  permitted by applicable  law, the Bank  reserves the right,  without
notice to the Borrower,  to charge interest,  from the date on which such amount
shall have first  become due and  payable by the  Borrower  to the date on which
such amount shall be paid by the Borrower (whether before or after judgment), at
an annual rate of interest  that shall at all times be five  percent  (5%) above
the annual rate of interest if such amount were not overdue. The unpaid interest
accrued on any overdue  amount in accordance  with Section 2.08 of the Agreement
shall  become and be  absolutely  due and payable by the Borrower to the Bank on
written  demand by the Bank at any time.  Interest on each  overdue  amount will
continue to accrue  monthly until the  obligations of the Borrower in respect of
the payment of such  overdue  amounts are  discharged  (whether  before or after
judgment).

      In the event that any  payment  shall not be  received  by the Bank by the
tenth  (10th)  day  following  the date on which such  payment is due,  the Bank
shall,  in addition to and not to the  exclusion  of its other rights under this
Note, be entitled to charge,  and the Borrower  shall pay the Bank a late charge
equal to the lesser of five percent (5%) of the overdue  payment or One Thousand
Dollars  ($1,000.00)  for the  purpose of  defraying  the  expense  incident  to
handling  the  delinquent  payment.  Late  charges  assessed  by  the  Bank  are
immediately  due and  payable.  Payments  are deemed  made on the  Business  Day
payment is  received by the Bank.  Payments  received  after 11:00 a.m.  will be
deemed received the next Business Day.

                                      E-12
<PAGE>

      The Borrower  agrees to pay all costs of enforcement or collection of this
Note and the Agreement, including reasonable attorney's fees and court costs, in
the event that the Borrower  defaults in its obligations  hereunder or under the
Agreement, whether suit be brought against the Borrower or not.

      This Note shall be the  obligation  of the maker and shall be binding upon
it and upon its successors, representatives and assigns.

      If  any  provision  contained  in  this  Note  is  in  conflict  with,  or
inconsistent  with, any provision in the Agreement,  the provision  contained in
the Agreement shall govern and control.

      This Note is referred to in the  Agreement and is entitled to the benefits
thereof  and may be  prepaid  in whole or in part as  provided  therein  without
premium  or  penalty.  Upon the  occurrence  of any one or more of the Events of
Default  specified in the Agreement,  all amounts then remaining  unpaid on this
Note may be declared to be immediately due and payable as provided therein.

      If this Note or any installment of principal or interest  hereunder is not
paid when due, the Bank may hold and apply any amounts which the Bank, from time
to time, may owe to the Borrower,  including any balance or share of any deposit
or other account, and any other property, tangible or intangible, owned by or in
which the Borrower has an interest  which may be in the possession or control of
the Bank. This right is in addition to the Bank's right of set-off.

      The  Borrower,  and any  endorsers,  guarantors,  sureties  and all  other
parties  liable  for  payment  of any sum or sums due or to become due under the
terms of this Note, jointly and severally waive presentment, demand for payment,
protest and notice of dishonor of this Note,  and authorize  the holder  hereof,
without notice,  to grant  extensions in the time of payment of any reduction or
increase in the rate of interest on any money owing on this Note.

      All  notices  and  other  communications   hereunder  shall  be  given  in
accordance with the terms and conditions of the Agreement.

      This Note has been  executed and  delivered in the State of New Jersey and
is to be governed  in all  respects by the laws of the State of New Jersey as an
agreement to be wholly performed in the State of New Jersey.


                                      E-13

<PAGE>

      This Note shall replace and supersede the Equipment  Promissory Note dated
May 27,  1993 issued in  connection  with the  Agreement,  as amended by a First
Restated  Equipment  Promissory Note dated July 14, 1994, and as further amended
by a Second  Restated  Equipment  Promissory  Note  dated as of May 31,  1996 to
evidence the indebtedness of the Borrower to the Bank represented  thereby which
indebtedness  hereafter  shall be  represented  by this  Note,  but shall not be
discharged,  released or reduced by this Note nor shall this Note  constitute  a
novation with respect to any such indebtedness.

      IN WITNESS  WHEREOF,  the  undersigned  have set their  hands and seals or
caused this $4,000,000 Third Restated  Equipment  Promissory Note to be executed
by their proper  corporate  officers and sealed with their seal  effective as of
May 31, 1997.

ATTEST                                            OSTEOTECH, INC.


/s/ STEVEN SOBIESKI                      BY: /s/MICHAEL J. JEFFRIES
- -------------------                      --------------------------
Name: Steven Sobieski                      Michael J. Jeffries,
Vice President Finance                     Executive Vice President,
                                           COO & CFO



                                      E-14

<PAGE>


                                    EXHIBIT A


                                 OSTEOTECH, INC.

                            EQUIPMENT ADVANCE REQUEST



Date of Request:

Date of Advance:

A)    Equipment Credit Balance (before advance):            $____________

B)    Amount of Requested Advance:                          $____________

New Equipment Credit Balance (A + B):                       $____________
      (cannot exceed $4,000,000.00)

Interest Rate (circle one):

               1. Base Rate
               2. Eurodollar Rate

Complete Description of Equipment,  including serial #'s if applicable:  (attach
copy of invoice)



                                                       -------------------------
                                                            Authorized Signature


                                      E-15




                                                                   EXHIBIT 10.32

                                   SUMMIT BANK
                               301 Carnegie Center
                                  P.O. Box 2066
                        Princeton, New Jersey 08543-2066

                                 SECOND RESTATED
                         REVOLVING LOAN PROMISSORY NOTE

$3,000,000                                                Middletown, New Jersey
                                                            Date: July 28, 1997

      FOR VALUE RECEIVED,  the undersigned  ("Borrower")  promises to pay to the
order of United Jersey Bank/Central,  N.A. ("Bank"),  at its executive office at
301 Carnegie Center, P.O. Box 2066, Princeton, New Jersey 08543-2066, or at such
other  place as the  Bank  may from  time to time  designate  by  notice  to the
Borrower, the principal sum of THREE MILLION ($3,000,000.00) DOLLARS, or so much
thereof as may be advanced as Revolving  Loan Advances  pursuant to the Loan and
Security  Agreement  between the Bank and the Borrower  dated May 27,  1993,  as
amended (the "Agreement"),  in lawful money of the United States of America with
interest,  calculated on the basis of a 360 day year, on the unpaid balance from
the date of this  Promissory  Note  ("Note")  at the rates set forth below until
paid. Any capitalized terms used herein shall have the meanings ascribed to them
in the Agreement.

      All amounts due to the Bank in connection with each Revolving Loan Advance
shall bear interest during each calendar month pursuant to the Borrower's Notice
of Advance at a  fluctuating  interest  rate per annum equal at all times to the
Bank's Base Rate in effect from time to time,  or two hundred (200) basis points
greater  than the  Eurodollar  Rate in effect  from time to time  until the Loan
Termination  Date.  Each  change in such  fluctuating  rate  shall  take  effect
simultaneously  with the  corresponding  change in such Base Rate or  Eurodollar
Rate, when applicable, without notice to the undersigned or any endorser, surety
or  guarantor.  Any such change shall not affect or alter any of the other terms
and conditions of this Note. All computations of interest shall be calculated on
a daily basis upon the unpaid  balance with each day  representing  1/360th of a
year. The undersigned  shall make monthly  payments of interest,  which payments
shall be due no later than the first Business Day of each calendar month,  until
the Loan  Termination Date whereupon all amounts due hereunder and in connection
herewith shall be immediately due and payable without notice.

      The terms,  covenants  and  conditions  of the Agreement are hereby made a
part of this Note,  to the extent and with the same  effect as if more fully set
forth  herein and the  Borrower  hereby  covenants  and promises to abide by and
comply with each and every term,  covenant and  condition set forth in this Note
and in the Agreement.

                                  E-16   

<PAGE>

      Notwithstanding  the  foregoing,  and  in  addition  to the  terms  of the
Agreement, the unpaid balance of the principal amount owing hereunder,  together
with interest thereon, shall immediately become due and payable, at the election
of the holder hereof, in the event of:

     (a) Failure to make any payment of principal or interest when due;

     (b) Failure to observe or perform any term,  covenant or  condition of this
Note or the Agreement with respect to the payment of money; and

     (c) Any Event of Default as defined in the Agreement.

      For each amount  payable by the  Borrower to the Bank under this Note that
is not paid by the tenth (10th) day  following the date on which such payment is
due (whether at the Loan Termination  Date, by acceleration or otherwise) and to
the extent  permitted by applicable  law, the Bank  reserves the right,  without
notice to the Borrower,  to charge interest,  from the date on which such amount
shall have first  become due and  payable by the  Borrower  to the date on which
such amount shall be paid by the Borrower (whether before or after judgment), at
the annual rate of interest  that shall at all times be five  percent (5%) above
the annual rate of interest if such amount were not overdue. The unpaid interest
accrued on any overdue  amount in accordance  with Section 2.08 of the Agreement
shall  become and be  absolutely  due and payable by the Borrower to the Bank on
written  demand by the Bank at any time.  Interest on each  overdue  amount will
continue to accrue  monthly until the  obligations of the Borrower in respect of
the payment of such  overdue  amounts are  discharged  (whether  before or after
judgment).

      In the event that any  payment  shall not be  received  by the Bank by the
tenth  (10th)  day  following  the date on which such  payment is due,  the Bank
shall,  in addition to and not to the  exclusion  of its other rights under this
Note, be entitled to charge,  and the Borrower  shall pay the Bank a late charge
equal to the lesser of five percent (5%) of the overdue  payment or One Thousand
Dollars  ($1,000.00)  for the  purpose of  defraying  the  expense  incident  to
handling  the  delinquent  payment.  Late  charges  assessed  by  the  Bank  are
immediately  due and  payable.  Payments  are deemed  made on the  Business  Day
payment is  received by the Bank.  Payments  received  after 11:00 a.m.  will be
deemed received the next Business Day.

      In the event  that the  outstanding  unpaid  principal  due to the Bank in
connection  with  Revolving  Loan  Advances  is less than  $3,000,000,  then the
Borrower shall pay to the Bank a quarterly fee

   
                                  E-17
<PAGE>

for the unused portion of the line equal to  one-quarter of one percent  (0.25%)
of the average daily unused portion of the line as more  particularly  described
in the Agreement.

      The Borrower  agrees to pay all costs of enforcement or collection of this
Note and the Agreement, including reasonable attorney's fees and court costs, in
the event that the Borrower  defaults in its obligations  hereunder or under the
Agreement, whether suit be brought against the Borrower or not.

      This Note shall be the  obligation  of the maker and shall be binding upon
it and upon its successors, representatives and assigns.

      If  any  provision  contained  in  this  Note  is  in  conflict  with,  or
inconsistent  with, any provision in the Agreement,  the provision  contained in
the Agreement shall govern and control.

      This Note is referred to in the  Agreement and is entitled to the benefits
thereof  and may be  prepaid  in whole or in part as  provided  therein  without
premium  or  penalty.  Upon the  occurrence  of any one or more of the Events of
Default  specified in the Agreement,  all amounts then remaining  unpaid on this
Note may be declared to be immediately due and payable as provided therein.

      If this Note or any installment of principal or interest  hereunder is not
paid when due, the Bank may hold and apply any amounts which the Bank, from time
to time, may owe to the Borrower,  including any balance or share of any deposit
or other account, and any other property, tangible or intangible, owned by or in
which the Borrower has an interest  which may be in the possession or control of
the Bank. This right is in addition to the Bank's right of set-off.

      The  Borrower,  and any  endorsers,  guarantors,  sureties  and all  other
parties  liable  for  payment  of any sum or sums due or to become due under the
terms of this Note, jointly and severally waive presentment, demand for payment,
protest and notice of dishonor of this Note,  and authorize  the holder  hereof,
without notice,  to grant  extensions in the time of payment of any reduction or
increase in the rate of interest on any money owing on this Note.

      All  notices  and  other  communications   hereunder  shall  be  given  in
accordance with the terms and conditions of the Agreement.

      This Note has been  executed and  delivered in the State of New Jersey and
is to be governed  in all  respects by the laws of the State of New Jersey as an
agreement to be wholly performed in the State of New Jersey.


                                      E-18
<PAGE>

      This Note shall replace and supersede the Revolving Loan  Promissory  Note
dated May 27,  1993 issued in  connection  with the  Agreement,  as amended by a
First Restated  Revolving Loan  Promissory  Note dated July 14, 1994 to evidence
the  indebtedness  of  the  Borrower  to  the  Bank  represented  thereby  which
indebtedness  hereafter  shall be  represented  by this  Note,  but shall not be
discharged,  released or reduced by this Note nor shall this Note  constitute  a
novation with respect to any such indebtedness.

      IN WITNESS  WHEREOF,  the  undersigned  have set their  hands and seals or
caused this  $3,000,000  Second  Restated  Revolving Loan  Promissory Note to be
executed by their proper corporate officers and sealed with their seal effective
as of May 31, 1997.


ATTEST                                            OSTEOTECH, INC.


/s/STEVEN SOBIESKI              BY:/s/ MICHAEL J. JEFFRIES
- ------------------              --------------------------
Steven Sobieski                    Michael J. Jeffries,
Vice President Finance             Executive Vice President
                                   COO, CFO

                                      E-19






                                                                   EXHIBIT 10.33

                          LICENSE AND OPTION AGREEMENT

                 This  Agreement  is  effective  June 27,  1997 ("the  EFFECTIVE
DATE") by and between H.C.  Implants  B.V., a  corporation  duly  organized  and
existing  under the laws of the  Netherlands,  having its  registered  office at
Zernikedreef 6 (2333GK)  Leiden,  the Netherlands,  (hereinafter  referred to as
"LICENSOR"),  and Matrix Medical Holding B.V., a corporation  duly organized and
existing  under the laws of the  Netherlands  having  its  registered  office at
Professor  Bronkhorsvlaan,  Building 57  (3723MB)  Bilthoven,  the  Netherlands,
(hereinafter referred to as "LICENSEE"),

WHEREAS

     o    LICENSOR  is  the  owner  or  licensee  of  the  patents   rights  and
          applications set forth in Appendix A hereto;

     o    LICENSEE has expressed the desire to obtain an exclusive  license with
          respect  to the  invention  set  forth  by  the  PATENTS  (as  defined
          hereinafter),  the  manufacture,  use,  sale and  distribution  of the
          invention  set  forth  by  the  PATENTS   and/or  any  other  form  of
          exploitation  of the PATENTS,  and a license to TECHNOLOGY (as defined
          hereinafter);  o  LICENSOR  has  expressed  the intent to grant such a
          license to LICENSEE and,  furthermore,  to grant LICENSEE an option to
          purchase the PATENTS;  NOW  THEREFORE in  consideration  of the mutual
          promises and other good and valuable consideration,  the parties agree
          as follows:

                                      E-20
<PAGE>
         SECTION 1 - Definitions.

          The terms used in this Agreement have the following meaning:

         1.1 The term "AFFILIATE" as applied to LICENSEE, shall mean any company
or other  legal  entity  other than  LICENSEE,  in whatever  country  organized,
controlling or controlled by LICENSEE.  The term "control" means possession,  of
the power to  direct  or cause the  direction  of the  management  and  policies
whether through the ownership of voting securities, by contract or otherwise.

         1.2 The term "FIRST  COMMERCIAL  SALE"  shall mean in each  country the
first sale of any PRODUCT by LICENSEE, its AFFILIATES or SUBLICENSEES, following
approval of its marketing by the appropriate governmental agency for the country
in which the sale is to be made and when governmental  approval is not required,
the first sale in that country.

         1.3 The term "NET SALES VALUE"  shall mean the invoiced  sales value of
the PRODUCTS sold by LICENSEE or its sublicensees after deduction of:

               1.3.1 the normal trade discounts actually granted;

               1.3.2 any credits  actually  given by the LICENSEE for  defective
          goods

               1.3.3 any costs of packing, insurance, damage and freight and any
          applicable  sales  tax and in the case of  export  orders  any  import
          duties or similar applicable  governmental  levies or export insurance
          costs in each case to the  extent  separately  invoiced.

     1.4 The term  "PATENTS"  shall  mean all  valid and  enforceable  claims of
patents and patent  applications  owned by or controlled by LICENSOR,  which are
filed  prior  to the  EFFECTIVE  DATE,  including  any  addition,  continuation,
continuation in-part or division thereof or any substitute application therefor,
any patent  issued  with  respect to such  patent  application;  any  reissue or
extension of any such


<PAGE>


patent,  and any  confirmation  patent  or  registration  patent or patent of an
addition based on any such patent. The patents,  patent applications,  and short
particulars of which shall be described in Appendix A hereto.

     1.5 The term "PRODUCTS" shall mean any and all products manufactured by the
use of all or some of the PATENTS and/or TECHNOLOGY.

     1.6 The  term  "TECHNOLOGY"  shall  mean  the  information,  test  reports,
operating and testing procedures,  data, files, studies,  practices and know-how
and the like,  in any way  related  to and/or  concerning  the  manufacture  and
distribution  of the  invention(s)  set forth by the PATENTS and all information
connected therewith, which exists as of the EFFECTIVE DATE and being provided by
LICENSOR to LICENSEE,

     1.7  The  term   "TERRITORY"   shall  mean  all  countries  of  the  world.

     1.8 The use herein of the plural shall include the singular, and the use of
the  masculine  shall include the  feminine.

SECTION 2 - Grants of License  and Option. 

     2.1 (a) Subject to Section  2.1(b),  LICENSOR hereby grants to LICENSEE and
LICENSEE  hereby accepts from LICENSOR an exclusive  royalty bearing license for
the TERRITORY  under PATENTS and  TECHNOLOGY to make,  have made,  use,  import,
sell,  offer to sell or have sold on its behalf PRODUCT,  including the right to
sublicense  third parties.  LICENSEE shall have the right to extend such license
to its AFFILIATES.

     (b)  LICENSOR  retains  the  rights to use the  TECHNOLOGY  and  PATENTS in
connection  with the following  products:  Shuttle Stop,  Middle Ear Ventilation
Tubes,  and TAM. In the event  LICENSOR  elects not to sell any of the foregoing
products, LICENSOR shall grant to LICENSEE a right of

                                     E-22
<PAGE>

first  negotiation  for an agreement  under which LICENSEE will  manufacture and
sell such products.  After receipt of a written notice to LICENSEE that LICENSOR
does not intend to manufacture and sell such products, the parties will, in good
faith,  negotiate the terms of an agreement during the next ninety (90) days. If
the parties are not able to agree  during that  period,  LICENSEE  shall have no
further rights with respect to such products and LICENSOR shall be free to enter
into an agreement  with other parties.

     (c) To the extent that any PATENTS,  TECHNOLOGY and PRODUCTS are covered by
the agreement between LICENSOR and Stichting Voor de Technische Wetenschappen of
December  20,  1989  and  any  supplements  and  amendments  thereto  (the  "STW
Agreement"),  this  Agreement  shall be  subject to the  terms,  conditions  and
obligations  of such STW  Agreement  and LICENSEE  shall be bound by such terms,
conditions and obligations.

     2.2 (a) Prior to exercising of the Purchase Option,  no sublicense shall be
granted without the consent of LICENSOR, which consent shall not be unreasonably
withheld.

     (b)  LICENSEE  agrees to  forward  to  LICENSOR a copy of any and all fully
executed sublicense agreements.

     (c) Each sublicense  shall terminate upon  termination of the license under
this Agreement.

     2.3 So  long  as  LICENSEE  is  not in  default  of any  provisions  of the
Agreement, from three (3) years and until six (6) years after the EFFECTIVE DATE
of this  Agreement,  LICENSEE  will have the option to purchase the PATENTS (the
"Purchase  Option")  for a purchase  price  equal to an  initial  payment of NLG
4,000,000  (four  million  Dutch  Guilders)  ("Initial  Payment") and a deferred
payment  equal to the running  royalties set forth in section 6.1. Such Purchase
Option shall be  exercised  by written  notice given by LICENSEE to the LICENSOR
and payment of the Initial Payment set forth herein. Upon payment by the

                                      E-23

<PAGE>

LICENSEE to the LICENSOR of NLG 4,000,000 Dutch Guilders, LICENSOR shall execute
a patent  assignment  agreement  in the form set forth in Appendix  B,  attached
hereto  and  made a part  hereof.

     2.4 If the LICENSEE  does not exercise  the  Purchase  Option,  the License
under this Agreement shall remain in full force and effect pursuant to the terms
of this  Agreement.  Upon  exercise  of the  Purchase  Option and payment of the
Initial  Payment all terms and  conditions  of this  Agreement  other than those
specifically related to the License shall continue in full force and effect. 

     2.5 (a) LICENSEE  shall exert best  efforts to  research,  develop and then
commercialize  PRODUCTS. The efforts of a SUBLICENSEE and/or an AFFILIATE and/or
a collaborator  of LICENSEE  shall be considered as efforts of LICENSEE.

     (b) If LICENSEE fails to exert best efforts as required by paragraph 2.5(a)
or fails to achieve any of the three milestones set forth below,  LICENSOR shall
have the right to convert the exclusive  license granted under paragraph  2.1(a)
to a non-exclusive license which shall take effect sixty (60) days after written
notice to LICENSEE  unless  LICENSEE  cures such failure  prior to expiration of
such sixty (60) day period. The three milestones are as follows:

                    (i)  during the first three years after the EFFECTIVE  DATE,
                         LICENSEE shall spend at least NLG 1.0 Million per annum
                         on the development of PRODUCTS covered by the PATENTS,

                    (ii) the first  full  clinical  trial of a  PRODUCT  that is
                         covered by PATENTS shall be initiated  before the third
                         anniversary  of the  EFFECTIVE  DATE, 

                    (iii)a PRODUCT  shall be marketed  by the sixth  anniversary
                         of the EFFECTIVE DATE.

                                      E-24

<PAGE>

                 (c) LICENSEE shall provide  LICENSOR with  semi-annual  reports
due  within  thirty  (30)  days  after the end of each  calendar  half year with
respect to the  efforts  exerted  under  this  Section  2.5 and with  respect to
progress towards and achievement of the milestones of Section 2.5(b).

     SECTION 3 - Rights and Obligations of the Parties under the Agreement:

     3.1  LICENSOR  will not be  required  to  perform  any  additional  work or
functions in connection with the granting of the license except to turn over the
TECHNOLOGY.

     3.2 Within 30 (thirty) days after the EFFECTIVE DATE,  LICENSOR will supply
LICENSEE with all  TECHNOLOGY in its possession  (that has not  previously  been
disclosed) and that is reasonably  necessary or desirable to enable  LICENSEE to
work the  TECHNOLOGY and PATENTS on a commercial  scale.

     3.3 LICENSEE  shall not represent  that LICENSEE is an agent of LICENSOR or
vice versa.

     3.4  LICENSEE  agrees  to  comply  with all laws,  rules,  regulations  and
reasonable standards of LICENSOR with respect to the PATENTS and with respect to
development, manufacture, use and sale of PRODUCTS.

SECTION 4-  Confidentiality.

     4.1 During the term of this Agreement,  it is contemplated  that each party
will disclose to the other proprietary and confidential technology,  inventions,
technical  information,  biological  materials  and the like  which are owned or
controlled  by the party  providing  such  information  or which  that  party is
obligated  to  maintain  in  confidence  and  which is  designated  by the party
providing such information as confidential  ("Confidential  Information").  Each
party agrees to retain the other party's Confidential Information in

                                      E-25
<PAGE>
confidence  and not to disclose  any such  Confidential  Information  to a third
party without the prior written consent of the party providing such  information
and to use the other party's  Confidential  Information only for the purposes of
this Agreement.

     4.2 The  obligations  of  confidentiality  will not  apply to  Confidential
Information which:

                    (i)  was known to the receiving  party or generally known to
                         the public prior to its disclosure hereunder; or

                    (ii) subsequently  becomes known to the public by some means
                         other than a breach of this Agreement;

                    (iii)is  subsequently  disclosed to the receiving party by a
                         third  party   having  a  lawful  right  to  make  such
                         disclosure;

                    (iv) is  required  by law or bona fide  legal  process to be
                         disclosed, provided that the party required to make the
                         disclosure  takes all reasonable  steps to restrict and
                         maintain   confidentiality   of  such   disclosure  and
                         provides  reasonable  notice to the party providing the
                         Confidential Information; or

                    (v)  is approved for release by the parties, or

                    (vi) is  independently  developed by the employees or agents
                         of  either   party   without  any   knowledge   of  the
                         Confidential Information provided by the other party.

         SECTION 5 - PATENTS.

     5.1 Until the PATENTS  are  purchased  by  LICENSEE,  LICENSOR  shall file,
prosecute and maintain PATENTS, and LICENSEE shall bear all the reasonable costs
and expenses for the filing, prosecution and maintenance of such PATENTS.

                                      E-26
<PAGE>

     5.2 With respect to any PATENTS,  each patent  application,  office action,
response to office  action,  request for  terminal  disclaimer,  and request for
reissue or reexamination  of any patent issuing from such  application  shall be
provided  to  LICENSEE  sufficiently  prior to the  filing of such  application,
response or request to allow for review and comment by LICENSEE.  LICENSOR shall
have the right to take any action that in its judgement is necessary to preserve
such PATENTS.

     5.3 Upon  exercise of the Purchase  Option and payment of the purchase fee,
LICENSEE  shall be  responsible  for  filing,  prosecution  and  maintenance  of
PATENTS. 

SECTION 6 - Compensation.

     6.1 (a) In  consideration  for the License  granted  under this  Agreement,
LICENSEE agrees to pay to LICENSOR an up front License Fee of NLG 1,000,000 (one
million Dutch  Guilders).  Such License Fee shall be paid in accordance with the
following  payment  schedule: 

                    (i)  NLG 500,000 (five hundred  thousand Dutch  Guilders) on
                         the EFFECTIVE DATE.

                    (ii) NLG 250,000 (two hundred fifty thousand Dutch Guilders)
                         on the first  anniversary  of the EFFECTIVE  DATE;  and

                    (iii)NLG  250,000  (two   hundred   fifth   thousand   Dutch
                         Guilders) on the second  anniversary  of the  EFFECTIVE
                         DATE.

     In the event any payment is not paid or this Agreement is terminated,  then
any unpaid portion of the NLG 1,000,000  shall be  immediately  due and payable.

     (b) LICENSEE shall pay to LICENSOR the following running royalty:

                    (i)  Until exercise of the Purchase  Option, a royalty equal
                         to five  percent  (5%) of the NET  SALES  VALUE  of all
                         PRODUCTS   sold  by   LICENSEE,   its   AFFILIATES   or
                         SUBLICENSEE. After exercise of the Purchase Option such
                         royalty shall be reduced to two percent (2%).

                                      E-27
<PAGE>


                    (ii) Beginning in year three of this Agreement,  the minimum
                         royalty shall be NLG 10,000 per year until the Purchase
                         Option is exercised.  Accordingly,  the minimum royalty
                         shall  be  paid  on  July  1,  2000  and  each  July  1
                         thereafter until the Purchase Option is exercised.  The
                         minimum  royalty  payment  of NLG  10,000 for each year
                         shall be credited  until  exhausted,  but only  against
                         royalties  due  for the  next  four  calendar  quarters
                         beginning with the July 1st quarter.

                    (iii)Upon exercise of the Purchase  Option,  LICENSEE  shall
                         receive a one time credit of NLG 400,000  (four-hundred
                         thousand  Dutch  Guilders)  with  respect  to  the  two
                         percent  (2%)  running  royalty.   In  addition,   upon
                         exercise  of the  Purchase  Option,  LICENSEE  shall be
                         obligated  to pay  the  royalties  due  under  the  STW
                         agreement.

     (c) The royalty  term on a PRODUCT by PRODUCT and country by country  basis
shall be for ten  (10)  years  from  FIRST  COMMERCIAL  SALE of a  PRODUCT  in a
country.  If at the end of such ten (10) years a PRODUCT is covered by a PATENT,
the royalty shall continue until the PRODUCT is not covered by a PATENT.

     6.2  LICENSEE  shall  keep,  and shall  cause  each of its  AFFILIATES  and
SUBLICENSEES  to  keep,  full  and  accurate  books of  account  containing  all
particulars  that may be necessary for the purpose of calculating  all royalties
payable to  LICENSOR.  Such books of  account  shall be kept at their  principal
place of business and, with all necessary  supporting data shall,  for the three
(3) years  next  following  the end of the  calendar  year to which  each  shall
pertain be open for inspection by an independent certified accountant reasonably
acceptable to LICENSEE upon  reasonable  notice during normal  business hours at
LICENSOR's

                                      E-28
<PAGE>
expense for the sole purpose of verifying royalty  statements or compliance with
this  Agreement,  but in no event  more than  once in each  calendar  year.  All
information  and data  offered  shall be used only for the purpose of  verifying
royalties and shall be treated as LICENSEE  Confidential  Information subject to
the  obligations  of  this  Agreement.   All  royalty   underpayments  shall  be
immediately due and payable.  In the event that such  inspection  shall indicate
that in any  calendar  year that the  royalties  which  should have been paid by
LICENSEE are at least five  percent (5%) greater than those which were  actually
paid by LICENSEE, then LICENSEE shall pay the cost of such inspection.


     6.3 With each quarterly payment,  LICENSEE shall deliver to LICENSOR a full
and  accurate  accounting  to include at least the  following  information: 

     (a)  Quantity  of each  PRODUCT  subject to royalty  sold (by  country)  by
LICENSEE, and its AFFILIATES and sublicensees;

     (b) Total invoiced sales for each PRODUCT subject to royalty (by country);

     (c) Deductions  permitted  against invoiced sales for calculating NET SALES
VALUE,

     (d) Total royalties payable to LICENSOR.

     (e) Any other information  reasonably requested by LICENSOR for determining
royalties  due to LICENSOR. 

     6.4 In each year the amount of royalty due shall be calculated quarterly as
of March 31, June 30,  September  30 and December 31 (each as being the last day
of an "Accounting  Period") and shall be paid  quarterly  within the thirty days
next  following  such  date,  every  such  payment  shall  be  supported  by the
accounting  prescribed  in  Paragraph  6.3 and shall be made in Dutch  Guilders.
Whenever royalty  conversion from any foreign  currency shall be required,  such
conversion  shall be calculated at the average rate of exchange for the calendar
quarter based on the daily rate of exchange for the calendar quarter.

                                      E-29
<PAGE>

     6.5 Any tax  required  to be  withheld  by  LICENSEE  under the laws of any
foreign country for the account of LICENSOR,  shall be promptly paid by LICENSEE
for and on behalf of LICENSOR to the  appropriate  governmental  authority,  and
LICENSEE shall furnish  LICENSOR with proof of payment of such tax. Any such tax
actually paid on LICENSOR's  behalf shall be deducted from royalty  payments due
LICENSOR.


         SECTION 7 - Infringement

         7.1 If any of the PATENTS under which LICENSEE is licensed hereunder is
infringed by a third party, LICENSEE shall have the right and option but not the
obligation to bring an action for  infringement,  at its sole  expense,  against
such third party in the name of LICENSOR and/or in the name of LICENSEE,  and to
join LICENSOR as a party  plaintiff if required.  LICENSEE shall promptly notify
LICENSOR of any such  infringement  and shall keep  LICENSOR  informed as to the
prosecution of any action for such infringement. No settlement, consent judgment
or other voluntary final disposition of the suit which adversely affects PATENTS
may be entered  into without the consent of LICENSOR,  which  consent  shall not
unreasonably  be  withheld.  LICENSEE  agrees  to  indemnify  and hold  LICENSOR
harmless  from any and all  damages,  costs and  expenses  which arise out of or
result from any action brought by LICENSEE under 7.1(a).

         7.2  In  the  event  that  LICENSEE  does  not  pursue  an  action  for
infringement,  upon within thiry (30) days after notice that an unlicensed third
party is an infringer of PATENTS  licensed to LICENSEE,  LICENSOR shall have the
right and  option,  but not the  obligation  at its cost and expense to initiate
infringement litigation and to retain any recovered damages.

                                      E-30

<PAGE>

         7.3 In the event  that  litigation  against  LICENSEE  or  LICENSOR  is
initiated by a third-party charging  infringement of a patent of the third party
as a result of the  manufacture,  use or sale by LICENSEE of PRODUCT  covered by
PATENTS,  LICENSEE shall promptly  notify  LICENSOR in writing thereof and shall
defend the parties hereto. LICENSEE shall bear all costs as to any such defense.

           SECTION 8 - Warranties.

     8.1 Each of LICENSOR and LICENSEE warrants and represents to the other that
it has the full right and authority to enter into this Agreement, and that it is
not aware of any impediment which would inhibit its ability to perform the terms
and conditions imposed on it by this Agreement.


     8.2 EXCEPT AS  OTHERWISE  EXPRESSLY  SET FORTH IN THIS  AGREEMENT  LICENSOR
MAKES NO  REPRESENTATIONS  OR EXTENDS ANY WARRANTIES OF ANY KIND, EITHER EXPRESS
OR  IMPLIED,  INCLUDING,  BUT NOT  LIMITED TO,  WARRANTIES  OF  MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE,  NON-INFRINGEMENT OR VALIDITY OF ANY PATENT OR
OTHER INTELLECTUAL PROPERTY RIGHTS. LICENSOR SHALL NOT BE LIABLE FOR ANY DAMAGES
ARISING AS A RESULT OF THIS AGREEMENT,  INCLUDING,  BUT NOT LIMITED TO, SPECIAL,
CONSEQUENTIAL,  PUNITIVE, INDIRECT DAMAGES OR INJURIES AND/OR LOSS OF PROFITS OR
REVENUES  OF LICENSEE OR ANY THIRD  PARTY. 

          SECTION 9 -  Indemnification. 

     9.1 (a)  LICENSEE  agrees to  indemnify  and hold  harmless  LICENSOR,  its
directors,  officers, employees, and agents, against any and all actions, claims
(specifically including, but not limited to,

                                      E-31

<PAGE>


any  damages  based  on  product  liability  claims),  suits,  losses,  demands,
judgments,  and other  liabilities  (including  attorney's  fees until  LICENSEE
assumes the defense as described  below)  asserted by third parties,  government
and  non-government,  resulting  from or arising out of this  Agreement  or as a
result  of  the  manufacture,  use  or  sale  of  PRODUCTS  and/or  any  alleged
infringement  by the  PATENTS  or other  statutory  or common  law  intellectual
property rights of a third party or any alleged passing off at common law or act
of unfair  competition  against a third party or  deception  or confusion of the
public related thereto.  If any such claims or actions are made,  LICENSOR shall
be defended  at  LICENSEE's  sole  expense by counsel  selected by LICENSEE  and
reasonably  acceptable to LICENSOR.  In the event that LICENSEE does not provide
acceptable counsel, LICENSOR shall have the right to select counsel and LICENSEE
shall pay the cost and expense  thereof.

     (b) LICENSOR  shall  notify  LICENSEE  promptly of any claim or  threatened
claim under this Section and shall fully cooperate with all reasonable  requests
of LICENSEE  with  respect  thereto.

     (c) The provisions of Section  9.1(a) shall be applicable  whether or not a
claim is rightfully  brought.


     SECTION 10- Assignment; Successors.

     10.1 This Agreement  shall not be assignable by LICENSEE  without the prior
written consent of LICENSOR. 

     10.2 Subject to the limitations on assignment herein,  this Agreement shall
be binding  upon and inure to the benefit of said  successors  in  interest  and
assigns of LICENSEE and  LICENSOR.  Any such  successor or assignee of a party's
interest shall expressly assume in writing the performance of all the terms

                                      E-32

<PAGE>


and  conditions  of this  Agreement  to be  performed  by said  party  and  such
Assignment  shall not relieve the Assignor of any of its obligations  under this
Agreement.


     SECTION 11 - Termination.

     11.1 Except as otherwise  specifically  provided  herein and unless  sooner
terminated pursuant to Paragraph 11.2 or 11.3 of this Agreement,  this Agreement
and the licenses and rights  granted  thereunder  shall remain in full force and
effect  until  the  expiration  of  LICENSEE'S   obligations  to  pay  royalties
hereunder,  at which time LICENSEE  shall have a fully  paid-up,  non-cancelable
license.

     11.2  Except as  provided  in  Section  2.5,  upon  breach of any  material
provisions of this  Agreement by LICENSEE,  in the event the breach is not cured
within sixty (60) days after written notice to the LICENSEE,  in addition to any
other  remedy  it may have,  LICENSOR  at its sole  option  may  terminate  this
Agreement.

     11.3  LICENSOR may  terminate  this  Agreement by giving  thirty (30) days'
written  notice to LICENSEE,  if LICENSEE  files for bankruptcy or bankruptcy of
LICENSEE is sought by a third party, or if the business of LICENSEE is placed in
the  possession of a receiver or a government  or government  agency or LICENSEE
becomes insolvent.

     11.4 Upon any termination of this Agreement LICENSEE,  at its option, shall
be entitled to finish any  work-in-progress  which is  completed  within six (6)
months of termination of this Agreement and to sell any completed inventory of a
PRODUCT  covered by this  Agreement  which remains on hand as of the date of the
termination,  so long as LICENSEE pays to LICENSOR the  royalties  applicable to
said  subsequent  sales in accordance  with the same terms and conditions as set
forth in this Agreement.

                                      E-33
<PAGE>

11.5 In the event that this  Agreement  and/or the rights and  licenses  granted
under this Agreement to LICENSEE are  terminated,  any sublicense  granted under
this Agreement shall remain in full force and effect as a direct license between
LICENSOR and the  SUBLICENSEE  under the terms and  conditions of the sublicense
agreement,  subject to the  SUBLICENSEE  agreeing to be bound to LICENSOR  under
such  terms and  conditions  within  thirty  (30) days after  LICENSOR  provides
written notice to the  SUBLICENSEE of the  termination of LICENSEE's  rights and
licenses  under this  Agreement.  At the  request  of  LICENSEE,  LICENSOR  will
acknowledge to a SUBLICENSEE  LICENSOR's  obligations to the  SUBLICENSEE  under
this paragraph.


     11.6 The obligations of Sections 4, 6.1, 8.2, 9, 11.4,  11.5,  11.6,  11.7,
11.8,  12.2 and 12.4 of this  Agreement  shall survive any  termination  of this
Agreement.

     11.7 In the event that the Agreement is  terminated or the license  granted
to  LICENSEE  becomes  non-exclusive,  LICENSEE  hereby  grants  to  LICENSOR  a
royalty-bearing,  non-exclusive  license to all patents and patent  applications
owned by LICENSEE which cover  PRODUCTS as well as to the technical  information
directed  thereto.  A  reasonable  royalty  shall be agreed  to by the  parties.

     11.8 Upon  termination  of this  Agreement for any reason,  nothing  herein
shall be construed  to release  either  party from any  obligation  that matured
prior   to  the   effective   date   of  such   termination. 

          SECTION 12 - General Provisions. 

     12.1 The relationship  between LICENSOR and LICENSEE is that of independent
contractors.  LICENSOR and LICENSEE are not joint venturers, partners, principal
and agent,  master and servant,  employer or employee,  and have no relationship
other than as independent contracting parties. LICENSOR

                                      E-34
<PAGE>

shall  have no power  to bind or  obligate  LICENSEE  in any  manner.  Likewise,
LICENSEE shall have no power to bind or obligate LICENSOR in any manner.

     12.2 Any matter or disagreement  or claim under this  Agreement,  including
interlocutory or preliminary measures,  shall be solely and exclusively referred
to and resolved by the competent  court in Amsterdam,  the  Netherlands,  unless
mandatory provisions of the laws of the Netherlands prescribe otherwise.

     12.3 This  Agreement  sets forth the  entire  agreement  and  understanding
between the parties as to the subject  matter  thereof and  supersedes all prior
agreements in this respect.  There shall be no  amendments or  modifications  to
this Agreement, except by a written document which is signed by both parties.

     12.4 This Agreement  shall be construed and enforced in accordance with the
laws of the Netherlands without reference to its choice of law principles.

     12.5 The headings in this Agreement have been inserted for the  convenience
of reference  only and are not intended to limit or expand on the meaning of the
language  contained  in the  particular  article or  section. 

     12.6 Any delay in enforcing a party's  rights  under this  Agreement or any
waiver as to a particular  default or other matter shall not constitute a waiver
of a party's right to the future enforcement of its rights under this Agreement,
excepting  only as to an expressed  written and signed waiver as to a particular
matter for a particular period of time. 

     12.7 Notices.  Any notices  given  pursuant to this  Agreement  shall be in
writing and shall be deemed to have been given and delivered upon the earlier of
(i) when  received at the address set forth  below,  or (ii) three (3)  business
days after mailed by certified or registered mail postage prepaid and properly

                                      E-35
<PAGE>

addressed,  with  return  receipt  requested,  or (iii) on the day when  sent by
facsimile  as  confirmed  by certified  or  registered  mail.  Notices  shall be
delivered to the respective parties as indicated:


                        To LICENSOR:      H.C. Implants B.V.
                                          Zernikedreef 6
                                          (2333GK) Leiden, the Netherlands

                        Copy to:          Carella, Byrne, Bain, Gilfillan,
                                          Cecchi, Stewart & Olstein
                                          6 Becker Farm Road
                                          Roseland, New Jersey 07068
                                          Fax no.(201)994-1744
                                          Attn: Elliot M. Olstein, Esq.

                        To LICENSEE:      Matrix Medical Holding B.V.
                                          Professor Bronkhorsvlaan, Building 57
                                          (3723MB) Bilthoven, The Netherlands


                                          cc:

     12.8 Only if required by law and/or regulations,  the PRODUCTS manufactured
by or through  LICENSEE will be marked  legibly with a statement that it is made
under a license from  LICENSOR and  containing a reference to the PATENTS as may
be relevant.

         IN WITNESS WHEREOF,  the parties have executed this Agreement as of the
date set forth above.

/s/ MICHAEL J. JEFFRIES                            /s/ CLEMENS VAN BLITTERSWIJK
- -----------------------                            ----------------------------
H.C. Implants, B.V.                                Matrix Medical Holding B.V.
Date:    June 18, 1997                             Date:   June 25, 1997
By:      Michael Jeffries                 By:      Clemens van Blitterswijk


                                      E-36

<PAGE>


                                     PATENTS

<TABLE>
<CAPTION>

- ------------------------------------------------------------------------------------------------------------------------------------
Master Name                                                            Serial No.        Status           Your File       Country
- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                                                                    <C>               <C>              <C>    <C>         
Tissue Adhesion (Barrier); Method for preventing tissue adhesion       08/279,811        5,480,436        525400-99       USA
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Tissue Adhesion (Barrier); Method for preventing tissue adhesion       08/078,350        5,508,306        525400-84       USA
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Tissue Adhesion (Barrier); Method for preventing tissue adhesion       P9:4011           Pending          525400-123      Norway
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Tissue Adhesion (Barrier); Method for preventing tissue adhesion       939108098         Pending          525400-127      Europe
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Tissue Adhesion (Barrier); Method for preventing tissue adhesion       70382394          Pending          525400-129      S. Korea
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Tissue Adhesion (Barrier); Method for preventing tissue adhesion       5-519441          Pending          525400-130      Japan
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Tissue Adhesion (Barrier); Method for preventing tissue adhesion       5155493           Pending          525400-131      Australia
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Tissue Adhesion (Barrier); Method for preventing tissue adhesion       21:8520           Pending          525400-132      Canada
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Artificial Skin                                                        574654            5,147,401        525400-151      USA
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Substrate for treating skin defect (Second PolyActive 
artificial skin)                                                       08/298,411        Pending          525400-112      USA
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Artificial Skin                                                        79107321          48126            525400-77       Taiwan
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Artificial Skin                                                        902023472         0416702          525400-76       Europe
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Artificial Skin                                                        9014038           Pending          525400-75       S. Korea
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Prosthetic Devices formed from materials having 
bone-bonding properties and uses                                       08/389,303        Pending          525400-126      USA
therefor.
Devices of method?
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Prosthetic Devices formed from materials having bone-bonding
properties and uses                                                     08/089,857        Pending          525400-68       USA
therefor.
Devices of method?
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Prosthetic Devices formed from materials having bone-bonding 
properties and uses                                                     892020226.0       357155           525400-69       Europe
therefor
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Prosthetic Devices formed from materials having bone-bonding
properties and uses                                                     12421/1989        Pending          525400-78       S. Korea
therefor
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Prosthetic Devices formed from materials having bone-bonding
properties and uses                                                     576657            Pending          525400-132      Canada
therefor
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Prosthetic Devices formed from materials having bone-bonding
properties and uses                                                     78106788          47733            525400-79       Taiwan
therefor
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
Polyester ester copolymers as drug delivery matrices                   08/699,896        Pending          525400-157      USA
- ------------------------------------------------------------------------------------------------------------------------------------
</TABLE>

                                      E-37
<PAGE>

                                   APPENDIX B

                               PATENT ASSIGNMENT


     This Assignment, effective as of the _____ day of __________, 199_, 

                                    W I T N E S S E T H:

     WHEREAS, H.C. Implants,  B.V., organized and existing under the laws of the
Netherlands,  having a place of business at Leiden, the Netherlands (hereinafter
"Assignor"), is the owner of all right, title and interest in and to the Patents
and Patent Applications and their foreign counterparts, identified on Appendix A
attached hereto, and the inventions claimed in said identified  patents,  patent
applications and certificates of inventions (hereinafter,  "the Property");  and


     WHEREAS,  Matrix Medical  Holding,  B.V.,  organized and existing under the
laws  of  the  Netherlands,  having  a  place  of  business  at  Bilthoven,  the
Netherlands  (hereinafter,  "Assignee"),  is  desirous of  acquiring  the entire
right, title and interest in and to the Property.

     NOW,  THEREFORE,  for the  consideration  as set forth in the  License  and
Option  Agreement  dated as of  __________________,  1997  between  Assignor and
Assignee,  and for  other  good and  valuable  consideration,  the  receipt  and
sufficiency of which is hereby acknowledged,  Assignor does hereby assign, sell,
transfer,  convey and grant  Assignee,  its successors  and assigns,  the entire
right,  title and interest in and to the Property,  including the right to apply
for,  Letters Patent and  certificates  of invention in Assignee's  name for the
aforesaid inventions in the United States and all countries foreign thereto, and
all reissues, extensions, renewals, reexaminations,  divisions and continuations
with respect to the  Property,  from the date hereof to the full end of the term
or terms for which the Property may be issued, the same to be held

                                     E-38
<PAGE>

and enjoyed by Assignee,  its  successors and assigns to the same extent that it
would have been held and  enjoyed by Assignor  if this  Assignment  had not been
made.

     Assignor  authorizes  and requests the Office of Patents and  Trademarks of
the  Netherlands  and the  corresponding  offices  of  countries  foreign to the
Netherlands to issue all Letters Patent which may issue on a patent  application
included in the Property to Assignee,  its successors and assigns, in accordance
with this Patent Assignment.

     Assignor  binds  itself,  as  well as its  successors,  assigns  and  legal
representatives to execute and deliver to Assignee,  its successors and assigns,
any further documents or instruments and do any and all further acts that may be
necessary  to vest in Assignee,  its  successors  and assigns,  the title herein
conveyed,  or intended so to be, and to the extent possible to enable such title
to be recorded in the Dutch Patent  Office and in the  corresponding  offices of
countries foreign to the Netherlands.

     Assignor  further  covenants,  and  agrees  that it will at any  time  upon
request communicate to Assignee, its successors and assigns, any facts pertinent
to the validity or enforceability of the Property and the history thereof, known
to Assignor or to its successors and assigns.

                                      E-39
<PAGE>

     IN WITNESS  WHEREOF,  the Assignor has caused these presents to be executed
by a duly authorized corporate officer this ______ day of _______________, 1997.

ATTEST:                                           H.C. IMPLANTS, B.V. (Assignor)


________________________                     By:______________________________



DATE: __________________                     Title:____________________________




COUNTRY OF                :
                                  :  SS
COUNTY OF                 :


         Before  me  this  ________  day  of  ______________,  1997,  personally
appeared the  above-named  _________________  to me known,  who being by me duly
sworn according to law, on his oath,  stated that he is the  ___________________
of H.C. Implants, B.V. and acknowledged that he signed, sealed and delivered the
foregoing instrument as the free and voluntary act and deed of said corporation.



- ------------------------------
Notary Public
My commission expires ______________



                                      E-40





                                                                    EXHIBIT 11.1


                        OSTEOTECH, INC. AND SUBSIDIARIES
                   COMPUTATION OF PRIMARY NET INCOME PER SHARE


<TABLE>
<CAPTION>

                                                                Three Months                         Six Months
                                                               Ended June 30,                      Ended June 30,
                                                    ------------------------------------- -------------------------------------
                                                                                          -----------------   ------------------
                                                         1997                1996            1997                   1996
                                                                    ----------------------                 ---
   -----------------------------------------------------------------   ---------------------------------------------------------

<S>                                                      <C>                   <C>              <C>                    <C>     
   Net income                                            $1,403,000            $202,000         $2,235,000             $373,000
                                                   ============================================================================

   Shares used in computing net income per share:

     Weighted average Common shares
      outstanding                                         7,950,510            7,760,941         7,926,274            7,662,884

     Weighted average Common shares
      issuable upon the exercise of
      outstanding stock options and
      warrants                                            1,705,928            1,587,724         1,738,652            1,693,852

     Application of assumed
      proceeds towards repurchase
      of outstanding Common shares
      using the Treasury Stock
      method                                               (974,556)(a)       (1,029,642)(a)  (1,042,451)(b)       (1,002,573)(b)
                                                   --------------------------------------------------------------------------------

         Shares used in computation                       8,681,882            8,319,023         8,662,475            8,354,163
                                                   =============================================================================

   Primary net income per share                                $.16                  $.02             $.26                 $.04
   =============================================================================================================================
</TABLE>


     a) Computed  using assumed  proceeds of $8,441,602 and average market value
of $8.66 in 1997 and proceeds of $7,242,503 and an average market value of $7.03
in 1996.

     b) Computed  using  assumed  proceeds of $8,581,460  and an average  market
value of $8.23 in 1997 and proceeds of $7,322,793 and an average market value of
$7.30 in 1996.


                                      E-41




                                                                    EXHIBIT 11.2

                        OSTEOTECH, INC. AND SUBSIDIARIES
                COMPUTATION OF FULLY DILUTED NET INCOME PER SHARE


<TABLE>
<CAPTION>

                                                                Three Months                                 Six Months
                                                               Ended June 30,                              Ended June 30,
                                                    --------------------------------- --- ----------------------------------
                                                         1997                1996             1997                   1996
    --------------------------------------------------------------------------------------------------------------------------

<S>                                                      <C>                   <C>               <C>                    <C>     
   Net income                                            $1,403,000            $202,000          $2,235,000             $373,000
                                                   ==============================================================================

   Shares used in computing net income per share:

     Weighted average Common shares
      outstanding                                         7,950,510            7,760,941          7,926,274            7,662,884

     Weighted average Common shares
      issuable upon the exercise of
      outstanding stock options and
      warrants                                            1,705,928            1,587,724          1,738,652            1,693,852

     Application of assumed
      proceeds towards repurchase
      of outstanding Common shares
      using the Treasury Stock
      method                                                (803,962)(a)        (998,966)(a)     (817,282)(b)        (1,002,573)(b)
                                                   ------------------------------------------------------------------------------

         Shares used in computation                       8,852,476            8,349,699      8,847,644                8,354,163
                                                   ==============================================================================

   Net income per share
        assuming full dilution                                 $.16                  $.02              $.25                 $.04
   ==============================================================================================================================
</TABLE>


     a) Computed using assumed proceeds of $8,441,602 and a closing market value
of $10.50 in 1997 and proceeds of $7,242,503 and a closing market value of $7.25
in 1996.

     b) Computed using assumed proceeds of $8,581,460 and a closing market value
of $10.50 in 1997 and  proceeds of  $7,322,793  and an average  market  value of
$7.30 in 1996.

                                      E-42


<TABLE> <S> <C>

<ARTICLE>                     5
<LEGEND>
This  schedule  contains  summary  financial   information  extracted  from  the
Osteotech,  Inc. and Subsidiaries Consolidated Balance Sheet as of June 30, 1997
and the Condensed  Consolidated Statement of Operations for the six months ended
June 30, 1997 and is qualified  in its  entirety by reference to such  financial
statements.
</LEGEND>
              
       
<S>
                                    <C>               <C>     
<PERIOD-TYPE>                      6-MOS               
<FISCAL-YEAR-END>                                        DEC-31-1997
<PERIOD-END>                                             JUN-30-1997
<CASH>                                                    $7,953,000
<SECURITIES>                                               3,445,000
<RECEIVABLES>                                              6,228,000
<ALLOWANCES>                                                 150,000
<INVENTORY>                                                  761,000
<CURRENT-ASSETS>                                          21,473,000
<PP&E>                                                    17,098,000
<DEPRECIATION>                                             8,541,000
<TOTAL-ASSETS>                                            33,327,000
<CURRENT-LIABILITIES>                                      6,874,000
<BONDS>                                                      517,000
                                              0
                                                        0
<COMMON>                                                      80,000
<OTHER-SE>                                                25,595,000
<TOTAL-LIABILITY-AND-EQUITY>                              33,327,000
<SALES>                                                    1,165,000
<TOTAL-REVENUES>                                          20,787,000
<CGS>                                                        862,000
<TOTAL-COSTS>                                             17,263,000
<OTHER-EXPENSES>                                                   0
<LOSS-PROVISION>                                                   0
<INTEREST-EXPENSE>                                            79,000
<INCOME-PRETAX>                                            3,758,000
<INCOME-TAX>                                               1,523,000
<INCOME-CONTINUING>                                        2,235,000
<DISCONTINUED>                                                     0
<EXTRAORDINARY>                                                    0
<CHANGES>                                                          0
<NET-INCOME>                                               2,235,000
<EPS-PRIMARY>                                                    .26
<EPS-DILUTED>                                                    .25
                                                                    


</TABLE>


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