OSTEOTECH INC
4, 1999-06-10
MISC HEALTH & ALLIED SERVICES, NEC
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                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     FORM 4

                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

     Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

[_]  Check box if no longer  subject of Section 16. Form 4 or Form 5 obligations
     may continue. See Instruction 1(b).

- --------------------------------------------------------------------------------
1.   Name and Address of Reporting Person*

     Stikeleather               Roger                  C.
- --------------------------------------------------------------------------------
   (Last)                           (First)             (Middle)
          c/o Osteotech, Inc.
          51 James Way
- --------------------------------------------------------------------------------
                                    (Street)

     Eatontown                  New Jersey             07724
- --------------------------------------------------------------------------------
   (City)                           (State)              (Zip)


- --------------------------------------------------------------------------------
2.   Issuer Name and Ticker or Trading Symbol

     Osteotech, Inc. (OSTE)

- --------------------------------------------------------------------------------
3.   IRS Identification Number of Reporting Person, if an Entity (Voluntary)



- --------------------------------------------------------------------------------
4.   Statement for Month/Year

     May 1999

- --------------------------------------------------------------------------------
5.   If Amendment, Date of Original (Month/Year)


- --------------------------------------------------------------------------------
6.   Relationship of Reporting Person to Issuer
     (Check all applicable)

     [_]  Director                             [_]  10% Owner
     [X]  Officer (give title below)           [_]  Other (specify below)

             Executive Vice President
             Sales and Marketing
- --------------------------------------------------------------------------------
7. Individual or Joint/Group Filing (Check applicable line)

     [X]  Form filed by one Reporting Person
     [_]  Form filed by more than one Reporting Person
- --------------------------------------------------------------------------------


================================================================================
           Table I -- Non-Derivative Securities Acquired, Disposed of,
                             or Beneficially Owned
================================================================================
<TABLE>
<CAPTION>
                                                                                                                6.
                                                                 4.                              5.             Owner-
                                                                 Securities Acquired (A) or      Amount of      ship
                                                    3.           Disposed of (D)                 Securities     Form:     7.
                                                    Transaction  (Instr. 3, 4 and 5)             Beneficially   Direct    Nature of
                                      2.            Code         ------------------------------- Owned at End   (D) or    Indirect
1.                                    Transaction   (Instr. 8)                   (A)             of Month       Indirect  Beneficial
Title of Security                     Date          ------------     Amount      or     Price    (Instr. 3      (I)       Ownership
(Instr. 3)                            (mm/dd/yy)     Code     V                  (D)             and 4)         (Instr.4) (Instr. 4)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                                   <C>            <C>      <C>    <C>         <C>    <C>         <C>            <C>       <C>


- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/17/99        M              22,596       A      $ 8.5000
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/17/99        M                 104       A      $ 8.5000
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/13/99        S               3,700       D      $38.1250
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/14/99        S               6,000       D      $37.0625
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/14/99        S               2,000       D      $37.0000
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/14/99        S               1,000       D      $36.9375
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/17/99        S               7,500       D      $36.5000
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/17/99        S               2,500       D      $36.6250
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/18/99        M              12,700       A      $ 8.5000
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/18/99        S               9,700       D      $36.7500
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/18/99        S               3,000       D      $36.6250
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/19/99        M               5,000       A      $ 8.5000
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/19/99        S               5,000       D      $36.7500
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/20/99        M               4,792       A      $ 8.5000
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/20/99        S               2,500       D      $36.6250
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          5/20/99        S               2,292       D      $36.5000    -0-            --        --
====================================================================================================================================
</TABLE>

Reminder: Report on a separate line for each class of securities beneficially
          owned directly or indirectly.

                            (Print or Type Responses)
                                                                          (Over)
(Form 4-07/98)

<PAGE>


FORM 4 (continued)

Table    II --  Derivative  Securities  Acquired,  Disposed of, or  Beneficially
         Owned (e.g., puts, calls, warrants, options, convertible securities)

================================================================================
<TABLE>
<CAPTION>
                                                                                                                   10.
                                                                                                         9.        Owner-
                                                                                                         Number    ship
                                                                                                         of        Form
                    2.                                                                                   Deriv-    of
                    Conver-                  5.                               7.                         ative     Deriv-   11.
                    sion                     Number of                        Title and Amount           Secur-    ative    Nature
                    or                       Derivative    6.                 of Underlying     8.       ities     Secur-   of
                    Exer-            4.      Securities    Date               Securities        Price    Bene-     ity:     In-
                    cise     3.      Trans-  Acquired (A)  Exercisable and    (Instr. 3 and 4)  of       ficially  Direct   direct
                    Price    Trans-  action  or Disposed   Expiration Date    ----------------  Deriv-   Owned     (D) or   Bene-
1.                  of       action  Code    of(D)         (Month/Day/Year)             Amount  ative    at End    In-      ficial
Title of            Deriv-   Date    (Instr. (Instr. 3,    ----------------             or      Secur-   of        direct   Owner-
Derivative          ative    (Month/ 8)      4 and 5)      Date     Expira-             Number  ity      Month     (I)      ship
Security            Secur-   Day/    ------  ------------  Exer-    tion                of      (Instr.  (Instr.   (Instr.  (Instr.
(Instr. 3)          ity      Year)   Code V   (A) (D)     cisable  Date      Title     Shares  5)       4)        4)       4)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                 <C>      <C>     <C>  <C> <C> <C>     <C>      <C>       <C>       <C>     <C>      <C>       <C>      <C>

- ------------------------------------------------------------------------------------------------------------------------------------
Employee Stock
Option (a)                                                                   Common
(Right to Buy)     $8.50(b) 5/17/99  M           22,596(c)  9/15/97  7/30/07 Stock    22,596(c)  --      --       --       --
- ------------------------------------------------------------------------------------------------------------------------------------

Employee Stock
Option (a)                                                                   Common
(Right to buy)     $8.50(b) 5/17/99  M              104(c) 11/11/97  7/30/07 Stock       104(c)  --      --       --       --
- ------------------------------------------------------------------------------------------------------------------------------------
Employee Stock
Option (a)                                                                   Common
(Right to buy)     $8.50(b) 5/18/99  M           12,700(c) 11/11/97  7/30/07 Stock    12,700(c)  --      --       --       --
- ------------------------------------------------------------------------------------------------------------------------------------
Employee Stock
Option (a)                                                                   Common
(Right to buy)     $8.50(b) 5/19/99  M            5,000(c) 11/11/97  7/30/07 Stock     5,000(c)  --      --       --       --
- ------------------------------------------------------------------------------------------------------------------------------------
Employee Stock
Option (a)                                                                   Common
(Right to buy)     $8.50(b) 5/20/99  M            4,792(c) 11/11/97  7/30/07 Stock     4,792(c)  --      --       --       --
- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- -----------------------------------------------------------------------------------------------------------------------------------

===================================================================================================================================
</TABLE>
Explanation of Responses:

     (a)  Granted under the Company's 1991 Stock Option Plan and qualified under
          Rule 16b-3.

     (b)  Pursuant to an adjustment  component of the option, the exercise price
          was adjusted to reflect a 3-for-2 stock split on March 19, 1999.

     (c)  Pursuant  to an  adjustment  component  of the option,  the  aggregate
          number of shares  issuable upon exercise of the option was adjusted to
          reflect a 3-for-2 stock split on March 19, 1999.



/s/ Roger C. Stikeleather                                     June 1, 1999
- ---------------------------------------------            -----------------------
      **Signature of Reporting Person                             Date

        Roger C. Stikeleather



**     Intentional misstatements or omissions of facts constitute Federal
       Criminal Violations.

       See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note:  File three copies of this Form, one of which must be manually signed.
       If space provided is insufficient, see Instruction 6 for procedure.


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