IDEC PHARMACEUTICALS CORP / DE
S-3/A, EX-1.1, 2000-11-09
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                        IDEC PHARMACEUTICALS CORPORATION

                            (a Delaware corporation)

                        1,600,000 Shares of Common Stock

                             U.S. PURCHASE AGREEMENT











                             Dated: November o, 2000
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<CAPTION>

                                TABLE OF CONTENTS

                             U.S. PURCHASE AGREEMENT

                                                                                                               PAGE

<S>                <C>                                                                                        <C>

SECTION 1.         REPRESENTATIONS AND WARRANTIES...............................................................3
        (a)        Representations and Warranties by the Company................................................3

                   (i)      Compliance with Registration Requirements...........................................4
                   (ii)     Incorporated Documents..............................................................5
                   (iii)    Independent Accountants.............................................................5
                   (iv)     Financial Statements................................................................5
                   (v)      No Material Adverse Change in Business..............................................5
                   (vi)     Good Standing of the Company........................................................6
                   (vii)    Good Standing of Subsidiaries.......................................................6
                   (viii)   Capitalization......................................................................6
                   (ix)     Authorization of Agreement..........................................................6
                   (x)      Authorization and Description of Securities.........................................7
                   (xi)     Absence of Defaults and Conflicts...................................................7
                   (xii)    Absence of Labor Dispute............................................................8
                   (xiii)   Absence of Proceedings..............................................................8
                   (xiv)    Accuracy of Exhibits................................................................8
                   (xv)     Possession of Intellectual Property.................................................8
                   (xvi)    Absence of Further Requirements.....................................................9
                   (xvii)   Possession of Licenses and Permits..................................................9
                   (xviii)  Title to Property...................................................................9
                   (xix)    Investment Company Act..............................................................9
                   (xx)     Environmental Laws.................................................................10
                   (xxi)    Filing of Tax Returns..............................................................10
                   (xxii)   Insurance..........................................................................10
                   (xxiii)  Interests in Corporation, Partnership or Joint Ventures............................11
                   (xxiv)   System of Internal Accounting Controls.............................................11
                   (xxv)    Solvency...........................................................................11
        (b)        Officer' s Certificates.....................................................................11

SECTION 2.         SALE AND DELIVERY TO U.S. UNDERWRITERS; CLOSING.............................................11
        (a)        Initial Securities..........................................................................11
        (b)        Option Securities...........................................................................11
        (c)        Payment.....................................................................................12
        (d)        Denominations; Registration.................................................................12

SECTION 3.         COVENANTS OF THE COMPANY....................................................................13
        (a)        Compliance with Securities Regulations and Commission Requests..............................13
        (b)        Filing of Amendments........................................................................13
        (c)        Delivery of Registration Statements.........................................................13
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<S>                <C>                                                                                         <C>
        (d)        Delivery of Prospectuses....................................................................14
        (e)        Continued Compliance with Securities Laws...................................................14
        (f)        Blue Sky Qualifications.....................................................................14
        (g)        Rule 158....................................................................................15
        (h)        Use of Proceeds.............................................................................15
        (i)        Listing.....................................................................................15
        (j)        Restriction on Sale of Securities...........................................................15
        (k)        Reporting Requirements......................................................................15

SECTION 4.         PAYMENT OF EXPENSES.........................................................................16
        (a)        Expenses....................................................................................16
        (b)        Termination of Agreement....................................................................16

SECTION 5.         CONDITIONS OF U.S. UNDERWRITERS' OBLIGATIONS................................................16
        (a)        Effectiveness of Registration Statement.....................................................16
        (b)        Opinion of Counsel for Company..............................................................17
        (c)        Opinion of Regulatory Affairs Counsel for the Company.......................................17
        (d)        Opinion of Intellectual Property Counsel for the Company....................................17
        (e)        Opinion of Counsel for Underwriters.........................................................17
        (f)        Officers' Certificate.......................................................................17
        (g)        Accountants' Comfort Letter.................................................................18
        (h)        Bring-down Comfort Letter...................................................................18
        (i)        Approval of Listing.........................................................................18
        (j)        No Objection................................................................................18
        (k)        Lock-up Agreements..........................................................................18
                   (ii)     Officers' Certificate..............................................................19
                   (iii)    Opinion of Counsel for Company.....................................................19
                   (iv)     Opinion of Counsel for U.S. Underwriters...........................................19
                   (v)      Bring-down Comfort Letter..........................................................19
        (l)        Additional Documents........................................................................19
        (m)        Termination of Agreement....................................................................19

SECTION 6.         INDEMNIFICATION.............................................................................20
        (a)        Indemnification of Underwriters.............................................................20
        (b)        Indemnification of Company, Directors and Officers..........................................20
        (c)        Actions against Parties; Notification.......................................................21
        (d)        Settlement without Consent if Failure to Reimburse..........................................21

SECTION 7.         CONTRIBUTION................................................................................22

SECTION 8.         REPRESENTATIONS, WARRANTIES AND AGREEMENTS TO SURVIVE DELIVERY..............................23

SECTION 9.         TERMINATION OF AGREEMENT....................................................................23
        (a)        Termination; General........................................................................23
        (b)        Liabilities.................................................................................23
                                       ii
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<S>                <C>                                                                                  <C>
SECTION 10.        DEFAULT BY ONE OR MORE OF THE UNDERWRITERS..................................................24

SECTION 11.        NOTICES.....................................................................................25

SECTION 12.        PARTIES.....................................................................................25

SECTION 13.        GOVERNING LAW AND TIME......................................................................25

SECTION 14.        EFFECT OF HEADINGS..........................................................................25

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<TABLE>
<S>                                                                                                       <C>
SCHEDULES

     Schedule A - List of Underwriters....................................................................Sch A-1
     Schedule B - Pricing Information.....................................................................Sch B-1
     [Schedule C - List of Persons and Entities Subject to Lock-Up........................................Sch C-1]

EXHIBITS

     Exhibit A - Form of Opinion of Company's Counsel.............................................. ..........A-1
     Exhibit B - Form of Opinion of Company's Regulatory Affairs Counsel........................... ..........B-1
     Exhibit C - Form of Opinion of Company's Intellectual Property Counsel........................ ..........C-1
     [Exhibit D - Form of Lock-up Letter........................................................... ..........D-1]

ANNEXES

     Annex A - Form of Accountants' Comfort Letter................................................. ....Annex A-1
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                                      iii
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                                                               Draft of 10/31/00



                        IDEC PHARMACEUTICALS CORPORATION
                            (a Delaware corporation)

                        1,600,000 Shares of Common Stock
                          (Par Value $0.0005 Per Share)

                             U.S. PURCHASE AGREEMENT

                                                                November o, 2000

MERRILL LYNCH & CO.
Merrill Lynch, Pierce, Fenner & Smith Incorporated
Salomon Smith Barney, Inc.
Banc of America Securities LLC
as U.S. Representatives of the several U.S. Underwriters
c/o  Merrill Lynch & Co.
     Merrill Lynch, Pierce, Fenner & Smith Incorporated
     North Tower
     World Financial Center
     New York, New York  10281

Ladies and Gentlemen:

     IDEC Pharmaceuticals Corporation, a Delaware corporation (the "Company"),
confirms its agreement with Merrill Lynch & Co., Merrill Lynch, Pierce, Fenner &
Smith Incorporated ("Merrill Lynch") and each of the other U.S. Underwriters
named in Schedule A hereto (collectively, the "U.S. Underwriters", which term
shall also include any underwriter substituted as hereinafter provided in
Section 10 hereof), for whom Merrill Lynch, Salomon Smith Barney, Inc. and Banc
of America Securities LLC are acting as representatives (in such capacity, the
"U.S. Representatives"), with respect to the issue and sale by the Company and
the purchase by the U.S. Underwriters, acting severally and not jointly, of the
respective numbers of shares of Common Stock, par value $0.0005 per share, of
the Company ("Common Stock") set forth in said Schedule A, and with respect to
the grant by the Company to the U.S. Underwriters, acting severally and not
jointly, of the option described in Section 2(b) hereof to purchase all or any
part of 240,000 additional shares of Common Stock to cover over-allotments, if
any. The aforesaid 1,600,000 shares of Common Stock (the "Initial U.S.
Securities") to be purchased by the U.S. Underwriters and all or any part of the
240,000 shares of Common Stock subject to the option described in Section 2(b)
hereof (the "U.S. Option Securities") are hereinafter called, collectively, the
"U.S. Securities".

     It is understood that the Company is concurrently entering into an
agreement dated the date hereof (the "International Purchase Agreement")
providing for the offering by the Company of an aggregate of 400,000 shares of
Common Stock (the "Initial International Securities") through arrangements with
certain underwriters outside the United States and Canada (the "International
Managers") for which Merrill Lynch International [and [NAME(S) OF INTERNATIONAL

                                       1
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CO-MANAGER(S)]] are acting as lead manager(s) (the "Lead Manager(s)") and the
grant by the Company to the International Managers, acting severally and not
jointly, of an option to purchase all or any part of the International Managers'
pro rata portion of up to 60,000 additional shares of Common Stock solely to
cover over-allotments, if any (the "International Option Securities" and,
together with the U.S. Option Securities, the "Option Securities"). The Initial
International Securities and the International Option Securities are hereinafter
called the "International Securities". It is understood that the Company is not
obligated to sell and the U.S. Underwriters are not obligated to purchase, any
Initial U.S. Securities unless all of the Initial International Securities are
contemporaneously purchased by the International Managers.

     The U.S. Underwriters and the International Managers are hereinafter
collectively called the "Underwriters", the Initial U.S. Securities and the
Initial International Securities are hereinafter collectively called the
"Initial Securities", and the U.S. Securities and the International Securities
are hereinafter collectively called the "Securities".

     The Underwriters will concurrently enter into an Intersyndicate Agreement
of even date herewith (the "Intersyndicate Agreement") providing for the
coordination of certain transactions among the Underwriters under the direction
of Merrill Lynch & Co., Merrill Lynch, Pierce, Fenner & Smith Incorporated (in
such capacity, the "Global Coordinator").

     The Company understands that the U.S. Underwriters propose to make a public
offering of the U.S. Securities as soon as the U.S. Representatives deem
advisable after this Agreement has been executed and delivered.

     The Company has filed with the Securities and Exchange Commission (the
"Commission") a registration statement on Form S-3 (No. 333-o) covering the
registration of the Securities under the Securities Act of 1933, as amended (the
"1933 Act"), including the related preliminary prospectus or prospectuses.
Promptly after execution and delivery of this Agreement, the Company will either
(i) prepare and file a prospectus in accordance with the provisions of Rule 430A
("Rule 430A") of the rules and regulations of the Commission under the 1933 Act
(the "1933 Act Regulations") and paragraph (b) of Rule 424 ("Rule 424(b)") of
the 1933 Act Regulations or (ii) if the Company has elected to rely upon Rule
434 ("Rule 434") of the 1933 Act Regulations, prepare and file a term sheet (a
"Term Sheet") in accordance with the provisions of Rule 434 and Rule 424(b). Two
forms of prospectus are to be used in connection with the offering and sale of
the Securities: one relating to the U.S. Securities (the "Form of U.S.
Prospectus") and one relating to the International Securities (the "Form of
International Prospectus"). The Form of International Prospectus is identical to
the Form of U.S. Prospectus, except for the front cover and back cover pages and
the information under the caption "Underwriting" and the inclusion in the Form
of International Prospectus of a section under the caption "Material United
States Federal Tax Considerations to Non-United States Holders." The information
included in any such prospectus or in any such Term Sheet, as the case may be,
that was omitted from such registration statement at the time it became
effective but that is deemed to be part of such registration statement at the
time it became effective (a) pursuant to paragraph (b) of Rule 430A is referred
to as "Rule 430A Information" or (b) pursuant to paragraph (d) of Rule 434 is
referred to as "Rule 434 Information". Each Form of U.S. Prospectus and Form of
International Prospectus used before such registration statement became
effective, and any prospectus that omitted, as applicable, the Rule 430A
Information or the Rule 434 Information,


                                       2
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that was used after such effectiveness and prior to the execution and delivery
of this Agreement, is herein called a "preliminary prospectus". Such
registration statement, including the exhibits thereto, schedules thereto, if
any, and the documents incorporated by reference therein pursuant to Item 12 of
Form S-3 under the 1933 Act, at the time it became effective and including the
Rule 430A Information and the Rule 434 Information, as applicable, is herein
called the "Registration Statement". Any registration statement filed pursuant
to Rule 462(b) of the 1933 Act Regulations is herein referred to as the "Rule
462(b) Registration Statement", and after such filing the term "Registration
Statement" shall include the Rule 462(b) Registration Statement. The final Form
of U.S. Prospectus and the final Form of International Prospectus, including the
documents incorporated by reference therein pursuant to Item 12 of Form S-3
under the 1933 Act, in the forms first furnished to the Underwriters for use in
connection with the offering of the Securities are herein called the "U.S.
Prospectus" and the "International Prospectus", respectively, and collectively,
the "Prospectuses". If Rule 434 is relied on, the terms "U.S. Prospectus" and
"International Prospectus" shall refer to the preliminary U.S. Prospectus dated
_____, 20__ and preliminary International Prospectus dated ____, 20__(11),
respectively, each together with the applicable Term Sheet and all references in
this Agreement to the date of such Prospectuses shall mean the date of the
applicable Term Sheet. For purposes of this Agreement, all references to the
Registration Statement, any preliminary prospectus, the U.S. Prospectus, the
International Prospectus or any Term Sheet or any amendment or supplement to any
of the foregoing shall be deemed to include the copy filed with the Commission
pursuant to its Electronic Data Gathering, Analysis and Retrieval system
("EDGAR").

     All references in this Agreement to financial statements and schedules and
other information which is "contained", "included" or "stated" in the
Registration Statement, any preliminary prospectus (including the Form of U.S.
Prospectus and Form of International Prospectus) or the Prospectuses (or other
references of like import) shall be deemed to mean and include all such
financial statements and schedules and other information which is incorporated
by reference in the Registration Statement, any preliminary prospectus
(including the Form of U.S. Prospectus and Form of International Prospectus) or
the Prospectuses, as the case may be; and all references in this Agreement to
amendments or supplements to the Registration Statement, any preliminary
prospectus or the Prospectuses shall be deemed to mean and include the filing of
any document under the Securities Exchange Act of 1934 (the "1934 Act") which is
incorporated by reference in the Registration Statement, such preliminary
prospectus or the Prospectuses, as the case may be.

     SECTION 1. REPRESENTATIONS AND WARRANTIES.

     (a) REPRESENTATIONS AND WARRANTIES BY THE COMPANY. The Company represents
and warrants to each U.S. Underwriter as of the date hereof, as of the Closing
Time referred to in Section 2(c) hereof, and as of each Date of Delivery (if
any) referred to in Section 2(b) hereof, and agrees with each U.S. Underwriter,
as follows:

                                       3
<PAGE>

          (i) COMPLIANCE WITH REGISTRATION REQUIREMENTS. The Company meets the
     requirements for use of Form S-3 under the 1933 Act. Each of the
     Registration Statement and any Rule 462(b) Registration Statement has
     become effective under the 1933 Act and no stop order suspending the
     effectiveness of the Registration Statement or any Rule 462(b) Registration
     Statement has been issued under the 1933 Act and no proceedings for that
     purpose have been instituted or are pending or, to the knowledge of the
     Company, are contemplated by the Commission, and any request on the part of
     the Commission for additional information has been complied with.

          At the respective times the Registration Statement, any Rule 462(b)
     Registration Statement and any post-effective amendments thereto became
     effective and at the Closing Time (and, if any U.S. Option Securities are
     purchased, at the Date of Delivery), the Registration Statement, the Rule
     462(b) Registration Statement and any amendments and supplements thereto
     complied and will comply in all material respects with the requirements of
     the 1933 Act and the 1933 Act Regulations and did not and will not contain
     an untrue statement of a material fact or omit to state a material fact
     required to be stated therein or necessary to make the statements therein
     not misleading. Neither of the Prospectuses nor any amendments or
     supplements thereto, at the time the Prospectuses or any amendments or
     supplements thereto were issued and at the Closing Time (and, if any U.S.
     Option Securities are purchased, at the Date of Delivery) included or will
     include an untrue statement of a material fact or omitted or will omit to
     state a material fact necessary in order to make the statements therein, in
     the light of the circumstances under which they were made, not misleading.
     If Rule 434 is used, the Company will comply with the requirements of Rule
     434. The representations and warranties in this subsection shall not apply
     to statements in or omissions from the Registration Statement or the U.S.
     Prospectus made in reliance upon and in conformity with information
     furnished to the Company in writing by any U.S. Underwriter through the
     U.S. Representative(s) expressly for use in the Registration Statement or
     the U.S. Prospectus.

          Each preliminary prospectus and the prospectuses filed as part of the
     Registration Statement as originally filed or as part of any amendment
     thereto, or filed pursuant to Rule 424 under the 1933 Act, complied when so
     filed in all material respects with the 1933 Act Regulations and each
     preliminary prospectus and the Prospectuses delivered to the Underwriters
     for use in connection with this offering was identical to the
     electronically transmitted copies thereof filed with the Commission
     pursuant to EDGAR, except to the extent permitted by Regulation S-T.

                                       4
<PAGE>

          (ii) INCORPORATED DOCUMENTS. The documents incorporated or deemed to
     be incorporated by reference in the Registration Statement and the
     Prospectuses, at the time they were or hereafter are filed with the
     Commission, complied and will comply in all material respects with the
     requirements of the 1934 Act and the rules and regulations of the
     Commission thereunder (the "1934 Act Regulations"), and, when read together
     with the other information in the Prospectuses, at the time the
     Registration Statement became effective, at the time the Prospectuses were
     issued and at the Closing Time (and if any U.S. Option Securities are
     purchased, at the Date of Delivery), did not and will not contain an untrue
     statement of a material fact or omit to state a material fact required to
     be stated therein or necessary to make the statements therein not
     misleading.

          (iii) INDEPENDENT ACCOUNTANTS. The accountants who certified the
     financial statements and supporting schedules included in the Registration
     Statement are independent public accountants as required by the 1933 Act
     and the 1933 Act Regulations.

          (iv) FINANCIAL STATEMENTS. The financial statements included in the
     Registration Statement and the Prospectuses, together with the related
     schedules and notes, present fairly the financial position of the Company
     and its consolidated subsidiaries at the dates indicated and the statement
     of operations, stockholders' equity and cash flows of the Company and its
     consolidated subsidiaries for the periods specified; said financial
     statements have been prepared in conformity with generally accepted
     accounting principles ("GAAP") applied on a consistent basis throughout the
     periods involved. The supporting schedules, if any, included in the
     Registration Statement present fairly in accordance with GAAP the
     information required to be stated therein. The selected financial data and
     the summary financial information included in the Prospectuses present
     fairly the information shown therein and have been compiled on a basis
     consistent with that of the audited financial statements included in the
     Registration Statement.

          (v) NO MATERIAL ADVERSE CHANGE IN BUSINESS. Since the respective dates
     as of which information is given in the Registration Statement and the
     Prospectuses, except as otherwise stated therein, (A) there has been no
     material adverse change in the condition, financial or otherwise, or in the
     earnings, business affairs or business prospects of the Company and its
     subsidiaries considered as one enterprise, whether or not arising in the
     ordinary course of business (a "Material Adverse Effect"), (B) there have
     been no transactions entered into by the Company or any of its
     subsidiaries, other than those in the ordinary course of business, which
     are material with respect to the Company and its subsidiaries considered as
     one enterprise, and (C) there has been no dividend or distribution of any
     kind declared, paid or made by the Company on any class of its capital
     stock.

                                       5
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          (vi) GOOD STANDING OF THE COMPANY. The Company has been duly organized
     and is validly existing as a corporation in good standing under the laws of
     the State of Delaware and has corporate power and corporate authority to
     own, lease and operate its properties and to conduct its business as
     described in the Prospectuses and to enter into and perform its obligations
     under this Agreement; and the Company is duly qualified as a foreign
     corporation to transact business and is in good standing in each other
     jurisdiction in which such qualification is required, whether by reason of
     the ownership or leasing of property or the conduct of business, except
     where the failure so to qualify or to be in good standing would not result
     in a Material Adverse Effect.

          (vii) GOOD STANDING OF SUBSIDIARIES. IDEC Seigaku [OTHERS] (the
     "Subsidiary") has been duly organized, is validly existing and is in good
     standing under the laws of the jurisdiction of its incorporation, with
     corporate power and corporate authority to own, lease and operate its
     properties and to conduct its business as described in the Prospectuses and
     is duly qualified to transact business as a foreign corporation and is in
     good standing in each other jurisdiction in which it owns or leases
     property of a nature or transacts business of a type that would make such
     qualification necessary, except to the extent that the failure so to
     qualify or to be in good standing would not have a Material Adverse Effect;
     all of the issued and outstanding capital stock of the Subsidiary has been
     duly authorized and validly issued, is fully paid and non-assessable and is
     wholly owned by the Company, directly, free and clear of any security
     interest, mortgage, pledge, lien, encumbrance, claim or equity; none of the
     outstanding shares of capital stock of the Subsidiary was issued in
     violation of the preemptive or similar rights of any security holder of the
     Subsidiary. The Subsidiary is the only subsidiary of the Company as of the
     date hereof.

          (viii) CAPITALIZATION. [The authorized, issued and outstanding capital
     stock and the debt of the Company is as set forth in the Prospectuses in
     the column entitled "Actual" under the caption "Capitalization" (except for
     subsequent issuances, if any, pursuant to this Agreement, pursuant to
     reservations, agreements or employee benefit plans referred to in the
     Prospectuses or pursuant to the exercise of convertible securities or
     options referred to in the Prospectuses).] The shares of issued and
     outstanding capital stock of the Company have been duly authorized and
     validly issued and are fully paid and non-assessable; none of the
     outstanding shares of capital stock of the Company was issued in violation
     of the preemptive or other similar rights of any security holder of the
     Company. The authorized capital stock of the Company conforms in all
     material respects as to legal matters to the description thereof contained
     in the Prospectuses.

          (ix) AUTHORIZATION OF AGREEMENT. This Agreement and the International
     Purchase Agreement have been duly authorized, executed and delivered by the
     Company.

                                       6
<PAGE>

          (x) AUTHORIZATION AND DESCRIPTION OF SECURITIES. The Securities to be
     purchased by the U.S. Underwriters and the International Managers from the
     Company have been duly authorized for issuance and sale to the U.S.
     Underwriters pursuant to this Agreement and the International Managers
     pursuant to the International Purchase Agreement, respectively, and, when
     issued and delivered by the Company pursuant to this Agreement and the
     International Purchase Agreement, respectively, against payment of the
     consideration set forth herein and the International Purchase Agreement,
     respectively, will be validly issued, fully paid and non-assessable; the
     Common Stock conforms to all statements relating thereto contained in the
     Prospectuses and such description conforms to the rights set forth in the
     instruments defining the same; no holder of the Securities will be subject
     to personal liability by reason of being such a holder; and the issuance of
     the Securities is not subject to the preemptive or other similar rights of
     any security holder of the Company.

          (xi) ABSENCE OF DEFAULTS AND CONFLICTS. Except as disclosed in the
     Prospectuses, neither the Company nor any of its subsidiaries is in
     violation of its charter or by-laws or in default in the performance or
     observance of any obligation, agreement, covenant or condition contained in
     any contract, indenture, mortgage, deed of trust, loan or credit agreement,
     note, lease or other agreement or instrument to which the Company or any of
     its subsidiaries is a party or by which it may be bound, or to which any of
     the property or assets of the Company or any subsidiary is subject
     (collectively, "Agreements and Instruments") except for such violations or
     defaults that would not result in a Material Adverse Effect; and the
     execution, delivery and performance of this Agreement and the International
     Purchase Agreement and the consummation of the transactions contemplated in
     this Agreement, the International Purchase Agreement and in the
     Registration Statement (including, without limitation, the issuance and
     sale of the Securities and the use of the proceeds from the sale of the
     Securities as described in the Prospectuses under the caption "Use of
     Proceeds") and compliance by the Company with its obligations under this
     Agreement and the International Purchase Agreement have been duly
     authorized by all necessary corporate action and do not and will not,
     whether with or without the giving of notice or passage of time or both,
     conflict with or constitute a breach of, or default or Repayment Event (as
     defined below) under, or result in the creation or imposition of any lien,
     charge or encumbrance upon any property or assets of the Company or any
     subsidiary pursuant to, the Agreements and Instruments (except for such
     conflicts, breaches or defaults or liens, charges or encumbrances that,
     singularly or in the aggregate, would not result in a Material Adverse
     Effect), nor will such action result in any violation of the provisions of
     the charter or by-laws of the Company or any subsidiary or any applicable
     law, statute, rule, regulation, judgment, order, writ or decree of any
     government, government instrumentality or court, domestic or foreign,
     having jurisdiction over the Company or any subsidiary or any of their
     assets or properties. As used herein, a "Repayment Event" means any event
     or condition which gives the holder of any note, debenture or other
     evidence of indebtedness (or any person acting on such holder's behalf) the
     right to require the repurchase, redemption or repayment of all or a
     portion of such indebtedness by the Company or any of its subsidiaries.

                                       7
<PAGE>

          (xii) ABSENCE OF LABOR DISPUTE. No labor dispute exists with the
     employees of the Company or with employees of any of its subsidiaries nor,
     to the knowledge of the Company, is any such labor dispute imminent, and
     the Company is not aware of any existing or imminent labor disturbance by
     the employees of any of its or any of its subsidiaries' principal
     suppliers, manufacturers, customers or contractors, or collaborative
     business partners, including Genentech, Inc., F. Hoffman-LaRoche, Inc.
     [Taisho Pharmaceuticals Co., Ltd and Schering Aktiengesellschaft
     [OTHERS]], which, in either case, may reasonably be expected to result in
     a Material Adverse Effect.

          (xiii) ABSENCE OF PROCEEDINGS. Except as disclosed in the
     Prospectuses, there is no action, suit, proceeding (except applications for
     regulatory approval from the Food and Drug Administration and foreign drug
     agencies), inquiry or investigation before or by any government,
     governmental instrumentality or court, domestic or foreign, now pending or,
     to the knowledge of the Company, threatened against or affecting the
     Company or any of its subsidiaries, as the case may be, that could
     reasonably be expected to have a Material Adverse Effect, or that could
     reasonably be expected individually or in the aggregate to materially and
     adversely affect the properties or assets of the Company or any of its
     subsidiaries, considered as one enterprise, or that could reasonably be
     expected to adversely affect the consummation of the transactions
     contemplated in this Agreement and the International Purchase Agreement or
     the performance by the Company of its obligations hereunder or thereunder.
     The aggregate of all pending legal or governmental proceedings to which the
     Company or any of its subsidiaries is a party or which affect any of its
     properties that are not described in the Registration Statement, including
     ordinary routine litigation incidental to the business, could not
     reasonably be expected to have a Material Adverse Effect.

          (xiv) ACCURACY OF EXHIBITS. There are no contracts or documents which
     are required to be described in the Registration Statement, the
     Prospectuses or the documents incorporated by reference therein or to be
     filed as exhibits thereto which have not been so described and filed as
     required.

          (xv) POSSESSION OF INTELLECTUAL PROPERTY. Except as disclosed in the
     Prospectuses, the Company and its subsidiaries own or possess, or can
     acquire on reasonable terms, adequate patents, patent rights, licenses,
     inventions, copyrights, know-how (including trade secrets and other
     unpatented and/or unpatentable proprietary or confidential information,
     systems or procedures), trademarks, service marks, trade names or other
     intellectual property (collectively, "Intellectual Property") necessary to
     carry on the business now operated by them, and neither the Company nor any
     of its subsidiaries has received any notice or is otherwise aware of any
     infringement of or conflict with asserted rights of others with respect to
     any Intellectual Property or of any facts or circumstances which would
     render any Intellectual Property invalid or inadequate to protect the
     interest of the Company or any of its subsidiaries therein, and which
     infringement or conflict (if the subject of any unfavorable decision,
     ruling or finding) or invalidity or inadequacy, singly or in the aggregate,
     would result in a Material Adverse Effect.

                                       8
<PAGE>

          (xvi) ABSENCE OF FURTHER REQUIREMENTS. No filing with, or
     authorization, approval, consent, license, order, registration,
     qualification or decree of, any court or governmental authority or agency
     is necessary or required for the performance by the Company of its
     obligations hereunder, in connection with the offering, issuance or sale of
     the Securities under this Agreement and the International Purchase
     Agreement or the consummation of the transactions contemplated by this
     Agreement and the International Purchase Agreement.

          (xvii) POSSESSION OF LICENSES AND PERMITS. Except as disclosed in the
     Prospectuses, the Company and its subsidiaries possess such licenses,
     approvals, consents and other authorizations (collectively, "Governmental
     Licenses") issued by the appropriate federal, state, local or foreign
     regulatory agencies or bodies necessary to conduct the business now
     operated by them; the Company and its subsidiaries are in compliance with
     the terms and conditions of all such Governmental Licenses, except where
     the failure so to comply would not, singly or in the aggregate, have a
     Material Adverse Effect; all of the Governmental Licenses are valid and in
     full force and effect, except when the invalidity of such Governmental
     Licenses or the failure of such Governmental Licenses to be in full force
     and effect would not have a Material Adverse Effect; and neither the
     Company nor any of its subsidiaries has received any notice of proceedings
     relating to the revocation or modification of any such Governmental
     Licenses which, singly or in the aggregate, if the subject of an
     unfavorable decision, ruling or finding, would result in a Material Adverse
     Effect.

          (xviii) TITLE TO PROPERTY. The Company and its subsidiaries have good
     and marketable title to all properties and assets owned by them, in each
     case, free and clear of all mortgages, pledges, liens, charges, security
     interests, claims, restrictions or encumbrances of any kind except such as
     (a) are described in the Prospectuses or (b) are neither material in amount
     nor materially significant in relation to the business of the Company and
     its subsidiaries, considered as one enterprise; and all of the leases and
     subleases material to the business of the Company and its subsidiaries,
     considered as one enterprise, and under which the Company or any of its
     subsidiaries holds properties described in the Prospectuses, are in full
     force and effect, and neither the Company nor any of its subsidiaries has
     any notice of any material claim of any sort that has been asserted by
     anyone adverse to the rights of the Company or any subsidiary under any of
     the leases or subleases mentioned above, or affecting or questioning the
     rights of the Company or any subsidiary to the continued possession of the
     leased or subleased premises under any such lease or sublease.

          (xix) INVESTMENT COMPANY ACT. The Company is not, and upon the
     issuance and sale of the Securities as herein contemplated and the
     application of the net proceeds therefrom as described in the Prospectuses
     will not be, an "investment company" or an entity "controlled" by an
     "investment company" as such terms are defined in the Investment Company
     Act of 1940, as amended (the "1940 Act").

                                       9
<PAGE>

          (xx) ENVIRONMENTAL LAWS. Except as described in the Registration
     Statement and except as would not, singly or in the aggregate, result in a
     Material Adverse Effect, (A) neither the Company nor any of its
     subsidiaries is in violation of any federal, state, local or foreign
     statute, law, rule, regulation, ordinance, code, policy or rule of common
     law or any judicial or administrative interpretation thereof, including any
     judicial or administrative order, consent, decree or judgment, relating to
     pollution or protection of human health, the environment (including,
     without limitation, ambient air, surface water, groundwater, land surface
     or subsurface strata) or wildlife, including, without limitation, laws and
     regulations relating to the release or threatened release of chemicals,
     pollutants, contaminants, wastes, toxic substances, hazardous substances,
     petroleum or petroleum products (collectively, "Hazardous Materials") or to
     the manufacture, processing, distribution, use, treatment, storage,
     disposal, transport or handling of Hazardous Materials (collectively,
     "Environmental Laws"), (B) the Company and its subsidiaries have all
     permits, authorizations and approvals required under any applicable
     Environmental Laws and are each in compliance with their requirements,
     except where the failure to be in compliance would not result in a Material
     Adverse Effect (C) there are no pending or, to the best knowledge of the
     Company, threatened administrative, regulatory or judicial actions, suits,
     demands, demand letters, claims, liens, notices of noncompliance or
     violation, investigation or proceedings relating to any Environmental Law
     against the Company or any of its subsidiaries and (D) to the best
     knowledge of the Company, there are no events or circumstances that might
     reasonably be expected to form the basis of an order for clean-up or
     remediation, or an action, suit or proceeding by any private party or
     governmental body or agency, against or affecting the Company or any of its
     subsidiaries relating to Hazardous Materials or any Environmental Laws.

          (xxi) FILING OF TAX RETURNS. The Company and each of its subsidiaries
     have filed all tax returns which are required to have been filed by them
     pursuant to domestic or foreign laws and have paid all taxes due pursuant
     to such returns or pursuant to any assessment received by them (except
     where the requirement for payment of such taxes is being contested in good
     faith in appropriate proceedings), except where the failure so to file or
     pay would not result in a Material Adverse Effect. The charges, accruals
     and reserves on the books of the Company and its subsidiaries in respect of
     taxes or other governmental charges are, to the best knowledge of the
     Company after reasonable investigation, adequate.

          (xxii) INSURANCE. The Company and the Subsidiary are insured by
     insurers of recognized financial responsibility against such losses and
     risks and in such amounts as are prudent and customary in the businesses in
     which they are engaged; neither the Company nor the Subsidiary has been
     refused any material insurance coverage sought or applied for that has not
     subsequently been approved by an insurance company with sound financial
     resources; and neither the Company nor the Subsidiary has any reason to
     believe that it will not be able to renew its existing insurance coverage
     as and when such coverage expires or to obtain similar coverage from
     similar insurers as may be necessary to continue its business at a cost
     that would not materially and adversely affect the condition, financial or
     otherwise, or the earnings, business or operations of the Company and the
     Subsidiary, taken as a whole.

                                       10
<PAGE>

          (xxiii) INTERESTS IN CORPORATION, PARTNERSHIP OR JOINT VENTURES. The
     Company does not own any equity or capital interests in any corporation,
     partnership, joint venture, association or other entity, other than the
     Subsidiary

          (xxiv) SYSTEM OF INTERNAL ACCOUNTING CONTROLS. The Company and its
     subsidiaries maintain a system of internal accounting controls sufficient
     to provide reasonable assurances that (A) transactions are executed in
     accordance with management's general or specific authorization, (B)
     transactions are recorded as necessary to permit preparation of financial
     statements in conformity with GAAP and to maintain accountability for
     assets, (C) access to assets is permitted only in accordance with
     management's general or specific authorization and (D) the recorded
     accountability for assets is compared with the existing assets at
     reasonable intervals and appropriate action is taken with respect to any
     differences.

          (xxv) SOLVENCY. The Company is, and immediately after the Closing Time
     or the Date of Delivery, as the case may be, will be, Solvent. As used
     herein, the term "Solvent" means, with respect to the Company on a
     particular date, that on such date (A) the fair market value of the assets
     of the Company is greater than the total amount of liabilities (including
     contingent liabilities) of the Company, (B) the present fair salable value
     of the assets of the Company is greater than the amount that will be
     required to pay the probable liabilities of the Company on its debts as
     they become absolute and matured, (C) the Company is able to realize upon
     its assets and pay its debts and other liabilities, including contingent
     obligations, as they mature, and (D) the Company does not have unreasonably
     small capital in relation to its business and operations.

     (b) OFFICER'S CERTIFICATES. Any certificate signed by any officer of the
Company or any of its subsidiaries delivered to the Global Coordinator, the U.S.
Representatives or to counsel for the U.S. Underwriters shall be deemed a
representation and warranty by the Company to each U.S. Underwriter as to the
matters covered thereby.

     SECTION 2. SALE AND DELIVERY TO U.S. UNDERWRITERS; CLOSING.

     (a) INITIAL SECURITIES. On the basis of the representations and warranties
herein contained and subject to the terms and conditions herein set forth, the
Company agrees to sell to each U.S. Underwriter, severally and not jointly, and
each U.S. Underwriter, severally and not jointly, agrees to purchase from the
Company, at the price per share set forth in Schedule B, the number of Initial
U.S. Securities set forth in Schedule A opposite the name of such U.S.
Underwriter, plus any additional number of Initial U.S. Securities which such
Underwriter may become obligated to purchase pursuant to the provisions of
Section 10 hereof.

     (b) OPTION SECURITIES. In addition, on the basis of the representations and
warranties herein contained and subject to the terms and conditions herein set
forth, the Company hereby grants an option to the U.S. Underwriters, severally
and not jointly, to purchase up to an additional 240,000 shares of Common Stock
at the price per share set forth in Schedule B, less an amount per share equal
to any dividends or distributions declared by the Company and payable on the
Initial U.S. Securities but not payable on the U.S. Option Securities. The
option hereby granted will expire 30 days after the date hereof and may be
exercised in whole or in part


                                       11
<PAGE>

from time to time only for the purpose of covering over-allotments which may be
made in connection with the offering and distribution of the Initial U.S.
Securities upon notice by the Global Coordinator to the Company setting forth
the number of U.S. Option Securities as to which the several U.S. Underwriters
are then exercising the option and the time and date of payment and delivery for
such U.S. Option Securities. Any such time and date of delivery for the U.S.
Option Securities (a "Date of Delivery") shall be determined by the Global
Coordinator, but shall not be later than seven full business days after the
exercise of said option, nor in any event prior to the Closing Time, as
hereinafter defined. If the option is exercised as to all or any portion of the
U.S. Option Securities, each of the U.S. Underwriters, acting severally and not
jointly, will purchase that proportion of the total number of U.S. Option
Securities then being purchased which the number of Initial U.S. Securities set
forth in Schedule A opposite the name of such U.S. Underwriter bears to the
total number of Initial U.S. Securities, subject in each case to such
adjustments as the Global Coordinator in its discretion shall make to eliminate
any sales or purchases of fractional shares.

     (c) PAYMENT. Payment of the purchase price for, and delivery of
certificates for, the Initial Securities shall be made at the offices of [INSERT
NAME AND ADDRESS], or at such other place as shall be agreed upon by the Global
Coordinator and the Company, at 9:00 A.M. (Eastern time) on the third (fourth,
if the pricing occurs after 4:30 P.M. (Eastern time) on any given day) business
day after the date hereof (unless postponed in accordance with the provisions of
Section 10), or such other time not later than ten business days after such date
as shall be agreed upon by the Global Coordinator and the Company (such time and
date of payment and delivery being herein called "Closing Time").

     In addition, in the event that any or all of the U.S. Option Securities are
purchased by the U.S. Underwriters, payment of the purchase price for, and
delivery of certificates for, such U.S. Option Securities shall be made at the
above-mentioned offices, or at such other place as shall be agreed upon by the
Global Coordinator and the Company, on each Date of Delivery as specified in the
notice from the Global Coordinator to the Company.

     Payment shall be made to the Company by wire transfer of immediately
available funds to a bank account designated by the Company, against delivery to
the U.S. Representative(s) for the respective accounts of the U.S. Underwriters
of certificates for the U.S. Securities to be purchased by them. It is
understood that each U.S. Underwriter has authorized the U.S. Representative(s),
for its account, to accept delivery of, receipt for, and make payment of the
purchase price for, the Initial U.S. Securities and the U.S. Option Securities,
if any, which it has agreed to purchase. Merrill Lynch, individually and not as
representative of the U.S. Underwriters, may (but shall not be obligated to)
make payment of the purchase price for the Initial U.S. Securities or the U.S.
Option Securities, if any, to be purchased by any U.S. Underwriter whose funds
have not been received by the Closing Time or the relevant Date of Delivery, as
the case may be, but such payment shall not relieve such U.S. Underwriter from
its obligations hereunder.

     (d) DENOMINATIONS; REGISTRATION. Certificates for the Initial U.S.
Securities and the U.S. Option Securities, if any, shall be in such
denominations and registered in such names as the U.S. Representative(s) may
request in writing at least one full business day before the Closing Time or the
relevant Date of Delivery, as the case may be. The certificates for the Initial
U.S.


                                       12
<PAGE>

Securities and the U.S. Option Securities, if any, will be made available for
examination and packaging by the U.S. Representative(s) in The City of New York
not later than 10:00 A.M. (Eastern time) on the business day prior to the
Closing Time or the relevant Date of Delivery, as the case may be.

     SECTION 3. COVENANTS OF THE COMPANY. The Company covenants with each U.S.
Underwriter as follows:

                  (a) COMPLIANCE WITH SECURITIES REGULATIONS AND COMMISSION
         REQUESTS. The Company, subject to Section 3(b), will comply with the
         requirements of Rule 430A or Rule 434, as applicable, and will notify
         the Global Coordinator immediately, and confirm the notice in writing,
         (i) when any post-effective amendment to the Registration Statement
         shall become effective, or any supplement to the Prospectuses or any
         amended Prospectuses shall have been filed, (ii) of the receipt of any
         comments from the Commission, (iii) of any request by the Commission
         for any amendment to the Registration Statement or any amendment or
         supplement to the Prospectuses or for additional information, and (iv)
         of the issuance by the Commission of any stop order suspending the
         effectiveness of the Registration Statement or of any order preventing
         or suspending the use of any preliminary prospectus, or of the
         initiation or threatening of any proceedings for any of such purposes.
         The Company will promptly effect the filings necessary pursuant to Rule
         424(b) and will take such steps as it deems necessary to ascertain
         promptly whether the form of prospectus transmitted for filing under
         Rule 424(b) was received for filing by the Commission and, in the event
         that it was not, it will promptly file such prospectus. The Company
         will make every reasonable effort to prevent the issuance of any stop
         order and, if any stop order is issued, to obtain the lifting thereof
         at the earliest possible moment.

                  (b) FILING OF AMENDMENTS. The Company will give the Global
         Coordinator notice of its intention to file or prepare any amendment to
         the Registration Statement (including any filing under Rule 462(b)),
         any Term Sheet or any amendment, supplement or revision to either any
         prospectus included in the Registration Statement at the time it became
         effective or to the Prospectuses, whether pursuant to the 1933 Act, the
         1934 Act or otherwise, will furnish the Global Coordinator with copies
         of any such documents a reasonable amount of time prior to such
         proposed filing or use, as the case may be, and will not file or use
         any such document to which the Global Coordinator or counsel for the
         U.S. Underwriters shall object.

                  (c) DELIVERY OF REGISTRATION STATEMENTS. The Company has
         furnished or will deliver to the U.S. Representative(s) and counsel for
         the U.S. Underwriters, without charge, signed copies of the
         Registration Statement as originally filed and of each amendment
         thereto (including exhibits filed therewith or incorporated by
         reference therein and documents incorporated or deemed to be
         incorporated by reference therein) and signed copies of all consents
         and certificates of experts, and will also deliver to the U.S.
         Representative(s), without charge, a conformed copy of the Registration
         Statement as originally filed and of each amendment thereto (without
         exhibits) for each of the U.S. Underwriters. The copies of the
         Registration Statement and each amendment thereto furnished to the U.S.
         Underwriters will be identical to the electronically transmitted

                                       13
<PAGE>

         copies thereof filed with the Commission pursuant to EDGAR, except to
         the extent permitted by Regulation S-T.

                  (d) DELIVERY OF PROSPECTUSES. The Company has delivered to
         each U.S. Underwriter, without charge, as many copies of each
         preliminary prospectus as such U.S. Underwriter reasonably requested,
         and the Company hereby consents to the use of such copies for purposes
         permitted by the 1933 Act. The Company will furnish to each U.S.
         Underwriter, without charge, during the period when the U.S. Prospectus
         is required to be delivered under the 1933 Act or the 1934 Act, such
         number of copies of the U.S. Prospectus (as amended or supplemented) as
         such U.S. Underwriter may reasonably request. The U.S. Prospectus and
         any amendments or supplements thereto furnished to the U.S.
         Underwriters will be identical to the electronically transmitted copies
         thereof filed with the Commission pursuant to EDGAR, except to the
         extent permitted by Regulation S-T.

                  (e) CONTINUED COMPLIANCE WITH SECURITIES LAWS. The Company
         will comply with the 1933 Act and the 1933 Act Regulations and the 1934
         Act and the 1934 Act Regulations so as to permit the completion of the
         distribution of the Securities as contemplated in this Agreement, the
         International Purchase Agreement and in the Prospectuses. If at any
         time when a prospectus is required by the 1933 Act to be delivered in
         connection with sales of the Securities, any event shall occur or
         condition shall exist as a result of which it is necessary, in the
         opinion of counsel for the U.S. Underwriters or for the Company, to
         amend the Registration Statement or amend or supplement any Prospectus
         in order that the Prospectuses will not include any untrue statements
         of a material fact or omit to state a material fact necessary in order
         to make the statements therein not misleading in the light of the
         circumstances existing at the time any such Prospectus is delivered to
         a purchaser, or if it shall be necessary, in the opinion of such
         counsel, at any such time to amend the Registration Statement or amend
         or supplement any Prospectus in order to comply with the requirements
         of the 1933 Act or the 1933 Act Regulations, the Company will promptly
         prepare and file with the Commission, subject to Section 3(b), such
         amendment or supplement as may be necessary to correct such statement
         or omission or to make the Registration Statement or the Prospectuses
         comply with such requirements, and the Company will furnish to the U.S.
         Underwriters such number of copies of such amendment or supplement as
         the U.S. Underwriters may reasonably request.

                  (f) BLUE SKY QUALIFICATIONS. The Company will use its best
         efforts, in cooperation with the U.S. Underwriters, to qualify the
         Securities for offering and sale under the applicable securities laws
         of such states and other jurisdictions as the Global Coordinator may
         designate and to maintain such qualifications in effect for a period of
         not less than one year from the later of the effective date of the
         Registration Statement and any Rule 462(b) Registration Statement;
         PROVIDED, HOWEVER, that the Company shall not be obligated to file any
         general consent to service of process or to qualify as a foreign
         corporation or as a dealer in securities in any jurisdiction in which
         it is not so qualified or to subject itself to taxation in respect of
         doing business in any jurisdiction in which it is not otherwise so
         subject. In each jurisdiction in which the Securities have been so
         qualified, the Company will file such statements and reports as may be
         required by the


                                       14
<PAGE>

          laws of such jurisdiction to continue such qualification in effect for
          a period of not less than one year from the effective date of the
          Registration Statement and any Rule 462(b) Registration Statement.

                  (g) RULE 158. The Company will timely file such reports
         pursuant to the 1934 Act as are necessary in order to make generally
         available to its security holders as soon as practicable an earnings
         statement for the purposes of, and to provide the benefits contemplated
         by, the last paragraph of Section 11(a) of the 1933 Act.

                  (h) USE OF PROCEEDS. The Company will use the net proceeds
         received by it from the sale of the Securities in the manner specified
         in the Prospectuses under "Use of Proceeds".

                  (i) LISTING. The Company will use its best efforts to effect
         and maintain the quotation of the Securities on the Nasdaq National
         Market and will file with the NASDAQ National Market all documents and
         notices required by the NASDAQ National Market of companies that have
         securities that are traded in the over-the-counter market and
         quotations for which are reported by the NASDAQ National Market.

                  (j) RESTRICTION ON SALE OF SECURITIES. During a period of 90
         days from the date of the Prospectuses, the Company will not, without
         the prior written consent of the Global Coordinator, directly or
         indirectly, (i) offer, pledge, sell, contract to sell, sell any option
         or contract to purchase, purchase any option or contract to sell, grant
         any option, right or warrant for the sale of, or otherwise transfer or
         dispose of any share of Common Stock or any securities convertible into
         or exercisable or exchangeable for Common Stock, whether now owned or
         hereinafter acquired by the Company or with respect to which the
         Company has or hereafter acquires the power of disposition, or file any
         registration statement under the 1933 Act with respect to any of the
         foregoing or (ii) enter into any swap or any other agreement or any
         transaction that transfers, in whole or in part, directly or
         indirectly, the economic consequence of ownership of the Common Stock,
         or any securities convertible into or exchangeable for Common Stock,
         whether any such swap or transaction described in clause (i) or (ii)
         above is to be settled by delivery of Common Stock or such other
         securities, in cash or otherwise. The foregoing sentence shall not
         apply to (A) the Securities to be sold hereunder or under the
         International Purchase Agreement, (B) any shares of Common Stock issued
         by the Company upon the exercise of an option or warrant or the
         conversion of a security outstanding on the date hereof and referred to
         in the Prospectuses, or (C) any shares of Common Stock issued or
         options to purchase Common Stock granted pursuant to existing employee
         benefit plans of the Company.

                  (k) REPORTING REQUIREMENTS. The Company, during the period
         when the Prospectuses are required to be delivered under the 1933 Act
         or the 1934 Act, will file all documents required to be filed with the
         Commission pursuant to the 1934 Act within the time periods required by
         the 1934 Act and the 1934 Act Regulations.

                                       15
<PAGE>

     SECTION 4. PAYMENT OF EXPENSES.

     (a) EXPENSES. The Company will pay all expenses incident to the performance
of its obligations under this Agreement, including (i) the preparation, printing
and filing of the Registration Statement (including financial statements and
exhibits) as originally filed and of each amendment thereto, (ii) the
preparation, printing and delivery to the Underwriters of this Agreement, any
Agreement among Underwriters and such other documents as may be required in
connection with the offering, purchase, sale, issuance or delivery of the
Securities, (iii) the preparation, issuance and delivery of the certificates for
the Securities to the Underwriters, including any stock or other transfer taxes
and any stamp or other duties payable upon the sale, issuance or delivery of the
Securities to the Underwriters and the transfer of the Securities between the
U.S. Underwriters and the International Managers, (iv) the fees and
disbursements of the Company's counsel, accountants and other advisors, (v) the
qualification of the Securities under securities laws in accordance with the
provisions of Section 3(f) hereof, including filing fees and the reasonable fees
and disbursements of counsel for the Underwriters in connection therewith and in
connection with the preparation of the Blue Sky Survey and any supplement
thereto, (vi) the printing and delivery to the Underwriters of copies of each
preliminary prospectus, any Term Sheets and of the Prospectuses and any
amendments or supplements thereto, (vii) the preparation, printing and delivery
to the Underwriters of copies of the Blue Sky Survey and any supplement thereto,
(viii) the fees and expenses of any transfer agent or registrar for the
Securities, (ix) the filing fees incident to, and the reasonable fees and
disbursements of counsel to the Underwriters in connection with, the review by
the National Association of Securities Dealers, Inc. (the "NASD") of the terms
of the sale of the Securities and (x) the fees and expenses incurred in
connection with the inclusion of the Securities in the NASDAQ National Market.

     (b) TERMINATION OF AGREEMENT. If this Agreement is terminated by the U.S.
Representatives in accordance with the provisions of Section 5 or Section
9(a)(i) hereof, the Company shall reimburse the U.S. Underwriters for all of
their out-of-pocket expenses, including the reasonable fees and disbursements of
counsel for the U.S. Underwriters.

     SECTION 5. CONDITIONS OF U.S. UNDERWRITERS' OBLIGATIONS. The obligations of
the several U.S. Underwriters hereunder are subject to the accuracy of the
representations and warranties of the Company contained in Section 1 hereof or
in certificates of any officer of the Company or any subsidiary of the Company
delivered pursuant to the provisions hereof, to the performance by the Company
of its covenants and other obligations hereunder, and to the following further
conditions:

          (a) EFFECTIVENESS OF REGISTRATION STATEMENT. The Registration
     Statement, including any Rule 462(b) Registration Statement, has become
     effective and at Closing Time no stop order suspending the effectiveness of
     the Registration Statement shall have been issued under the 1933 Act or
     proceedings therefor initiated or threatened by the Commission, and any
     request on the part of the Commission for additional information shall have
     been complied with to the reasonable satisfaction of counsel to the U.S.
     Underwriters. A prospectus containing the Rule 430A Information shall have
     been filed with the Commission in accordance with Rule 424(b) (or a
     post-effective amendment providing such information shall have been filed
     and declared effective in accordance


                                       16
<PAGE>

     with the requirements of Rule 430A) or, if the Company has elected to rely
     upon Rule 434, a Term Sheet shall have been filed with the Commission in
     accordance with Rule 424(b).

          (b) OPINION OF COUNSEL FOR COMPANY. At Closing Time, the U.S.
     Representatives shall have received the favorable opinion, dated as of
     Closing Time, of Pillsbury Madison & Sutro LLP, counsel for the Company, in
     form and substance satisfactory to counsel for the U.S. Underwriters,
     together with signed or reproduced copies of such letter for each of the
     other U.S. Underwriters to the effect set forth in Exhibit A hereto and to
     such further effect as counsel to the U.S. Underwriters may reasonably
     request.

          (c) OPINION OF REGULATORY AFFAIRS COUNSEL FOR THE COMPANY. At the
     Closing Time, the U.S. Representatives shall have received the opinion,
     dated as of the Closing Time, of Buc & Beardsley, special regulatory
     affairs counsel for the Company, in form and substance reasonably
     satisfactory to counsel for the U.S. Underwriters, to the effect set forth
     in Exhibit B hereto and to such further effect as counsel to the U.S.
     Underwriters may reasonably request.

          (d) OPINION OF INTELLECTUAL PROPERTY COUNSEL FOR THE COMPANY. At the
     Closing Time, the U.S. Representatives shall have received the opinion,
     dated as of the Closing Time, of  o , intellectual property counsel for the
     Company, in form and substance reasonably satisfactory to counsel for the
     U.S. Underwriters, to the effect set forth in Exhibit C hereto and to such
     further effect as counsel to the U.S. Underwriters may reasonably request.

          (e) OPINION OF COUNSEL FOR UNDERWRITERS. At Closing Time, the U.S.
     Representatives shall have received the favorable opinion, dated as of
     Closing Time, of Shearman & Sterling, counsel for the U.S. Underwriters, in
     form and substance reasonably satisfactory to the U.S. Underwriters. In
     giving such opinion such counsel may rely, as to all matters governed by
     the laws of jurisdictions other than the law of the State of New York, the
     federal law of the United States and the General Corporation Law of the
     State of Delaware, upon the opinions of counsel satisfactory to the U.S.
     Representatives. Such counsel may also state that, insofar as such opinion
     involves factual matters, they have relied, to the extent they deem proper,
     upon certificates of officers of the Company and its subsidiaries and
     certificates of public officials.

          (f) OFFICERS' CERTIFICATE. At Closing Time, there shall not have been,
     since the date hereof or since the respective dates as of which information
     is given in the Prospectuses, any material adverse change in the condition,
     financial or otherwise, or in the earnings, business affairs or business
     prospects of the Company and its subsidiaries considered as one enterprise,
     whether or not arising in the ordinary course of business, and the U.S.
     Representative(s) shall have received a certificate of the President or a
     Vice President of the Company and of the chief financial or chief
     accounting officer of the Company, dated as of Closing Time, to the effect
     that (i) there has been no such material adverse change, (ii) the
     representations and warranties in Section 1(a) hereof are true and correct
     with the same force and effect as though expressly made at and as of
     Closing


                                       17
<PAGE>

     Time, (iii) the Company has complied with all agreements and satisfied all
     conditions on its part to be performed or satisfied at or prior to Closing
     Time, and (iv) no stop order suspending the effectiveness of the
     Registration Statement has been issued and no proceedings for that purpose
     have been instituted or are pending or are contemplated by the Commission.

          (g) ACCOUNTANTS' COMFORT LETTER. At the time of the execution of this
     Agreement, the U.S. Representatives shall have received from KPMG LLP a
     letter dated such date, in form and substance satisfactory to the U.S.
     Representatives, together with signed or reproduced copies of such letter
     for each of the other U.S. Underwriters containing statements and
     information of the type ordinarily included in accountants' "comfort
     letters" to underwriters with respect to the financial statements and
     certain financial information contained in the Registration Statement and
     the Prospectuses.

          (h) BRING-DOWN COMFORT LETTER. At Closing Time, the Representatives
     shall have received from KPMG LLP a letter, dated as of Closing Time, to
     the effect that they reaffirm the statements made in the letter furnished
     pursuant to subsection (g) of this Section, except that the specified date
     referred to shall be a date not more than three business days prior to
     Closing Time.

          (i) APPROVAL OF LISTING. At Closing Time, the Securities shall have
     been approved for inclusion in the Nasdaq National Market, subject only to
     official notice of issuance.

          (j) NO OBJECTION. The NASD has confirmed that it has not raised any
     objection with respect to the fairness and reasonableness of the
     underwriting terms and arrangements.

          (k) LOCK-UP AGREEMENTS. At the date of this Agreement, the U.S.
     Representatives shall have received an agreement substantially in the form
     of Exhibit D hereto signed by the persons listed on Schedule C hereto.

          (l) PURCHASE OF INITIAL INTERNATIONAL SECURITIES. Contemporaneously
     with the purchase by the U.S. Underwriters of the Initial U.S. Securities
     under this Agreement, the International Managers shall have purchased the
     Initial International Securities under the International Purchase
     Agreement.

          (m) CONDITIONS TO PURCHASE OF U.S. OPTION SECURITIES. In the event
     that the U.S. Underwriters exercise their option provided in Section 2(b)
     hereof to purchase all or any portion of the U.S. Option Securities, the
     representations and warranties of the Company contained herein and the
     statements in any certificates furnished by the Company or any subsidiary
     of the Company hereunder shall be true and correct as of each Date of
     Delivery and, at the relevant Date of Delivery, the U.S. Representatives
     shall have received:

                                       18
<PAGE>

               (ii) OFFICERS' CERTIFICATE. A certificate, dated such Date of
          Delivery, of the President or a Vice President of the Company and of
          the chief financial or chief accounting officer of the Company
          confirming that the certificate delivered at Closing Time pursuant to
          Section 5(f) hereof remains true and correct as of such Date of
          Delivery.

               (iii) OPINION OF COUNSEL FOR COMPANY. The favorable opinion of
          Pillsbury Madison & Sutro LLP, counsel for the Company, together with
          the favorable opinion of Buc & Beardsley, special regulatory affairs
          counsel for the Company, and  o , intellectual property counsel for
          the Company, each in form and substance satisfactory to counsel for
          the U.S. Underwriters, dated such Date of Delivery, relating to the
          U.S. Option Securities to be purchased on such Date of Delivery and
          otherwise to the same effect as the opinions required by Sections
          5(b), 5(c) and 5(d) hereof.

               (iv) OPINION OF COUNSEL FOR U.S. UNDERWRITERS. The favorable
          opinion of Shearman & Sterling, counsel for the U.S. Underwriters,
          dated such Date of Delivery, relating to the U.S. Option Securities to
          be purchased on such Date of Delivery and otherwise to the same effect
          as the opinion required by Section 5(e) hereof.

               (v) BRING-DOWN COMFORT LETTER. A letter from KPMG LLP, in form
          and substance satisfactory to the U.S. Representatives and dated such
          Date of Delivery, substantially in the same form and substance as the
          letter furnished to the U.S. Representatives pursuant to Section 5(h)
          hereof, except that the "specified date" in the letter furnished
          pursuant to this paragraph shall be a date not more than five days
          prior to such Date of Delivery.

          (l) ADDITIONAL DOCUMENTS. At Closing Time and at each Date of
     Delivery, counsel for the U.S. Underwriters shall have been furnished with
     such documents and opinions as they may require for the purpose of enabling
     them to pass upon the issuance and sale of the Securities as herein
     contemplated, or in order to evidence the accuracy of any of the
     representations or warranties, or the fulfillment of any of the conditions,
     herein contained; and all proceedings taken by the Company in connection
     with the issuance and sale of the Securities as herein contemplated shall
     be satisfactory in form and substance to the U.S. Representatives and
     counsel for the U.S. Underwriters.

          (m) TERMINATION OF AGREEMENT. If any condition specified in this
     Section shall not have been fulfilled when and as required to be fulfilled,
     this Agreement, or, in the case of any condition to the purchase of U.S.
     Option Securities on a Date of Delivery which is after the Closing Time,
     the obligations of the several U.S. Underwriters to purchase the relevant
     Option Securities, may be terminated by the U.S. Representatives by notice
     to the Company at any time at or prior to Closing Time or such Date of
     Delivery, as the case may be, and such termination shall be without
     liability of any party to any other party except as provided in Section 4
     and except that Sections 1, 6, 7 and 8 shall survive any such termination
     and remain in full force and effect.

                                       19
<PAGE>

     SECTION 6. INDEMNIFICATION.

     (a) INDEMNIFICATION OF U.S. UNDERWRITERS. The Company agrees to indemnify
and hold harmless each U.S. Underwriter and each person, if any, who controls
any U.S. Underwriter within the meaning of Section 15 of the 1933 Act or Section
20 of the 1934 Act as follows:

          (i) against any and all loss, liability, claim, damage and expense
     whatsoever, as incurred, arising out of any untrue statement or alleged
     untrue statement of a material fact contained in the Registration Statement
     (or any amendment thereto), including the Rule 430A Information and the
     Rule 434 Information, if applicable, or the omission or alleged omission
     therefrom of a material fact required to be stated therein or necessary to
     make the statements therein not misleading or arising out of any untrue
     statement or alleged untrue statement of a material fact included in any
     preliminary prospectus or the Prospectuses (or any amendment or supplement
     thereto), or the omission or alleged omission therefrom of a material fact
     necessary in order to make the statements therein, in the light of the
     circumstances under which they were made, not misleading;

          (ii) against any and all loss, liability, claim, damage and expense
     whatsoever, as incurred, to the extent of the aggregate amount paid in
     settlement of any litigation, or any investigation or proceeding by any
     governmental agency or body, commenced or threatened, or of any claim
     whatsoever based upon any such untrue statement or omission, or any such
     alleged untrue statement or omission; provided that (subject to Section
     6(d) below) any such settlement is effected with the written consent of the
     Company; and

          (iii) against any and all expense whatsoever, as incurred (including
     the fees and disbursements of counsel chosen by Merrill Lynch), reasonably
     incurred in investigating, preparing or defending against any litigation,
     or any investigation or proceeding by any governmental agency or body,
     commenced or threatened, or any claim whatsoever based upon any such untrue
     statement or omission, or any such alleged untrue statement or omission, to
     the extent that any such expense is not paid under (i) or (ii) above;

PROVIDED, HOWEVER, that this indemnity agreement shall not apply to any loss,
liability, claim, damage or expense to the extent arising out of any untrue
statement or omission or alleged untrue statement or omission made in reliance
upon and in conformity with written information furnished to the Company by any
U.S. Underwriter through the U.S. Representatives expressly for use in the
Registration Statement (or any amendment thereto), including the Rule 430A
Information and the Rule 434 Information, if applicable, or any preliminary
prospectus or the U.S. Prospectus (or any amendment or supplement thereto).

         (b) INDEMNIFICATION OF COMPANY, DIRECTORS AND OFFICERS. Each U.S.
Underwriter severally agrees to indemnify and hold harmless the Company, its
directors, each of its officers who signed the Registration Statement, and each
person, if any, who controls the Company within the meaning of Section 15 of the
1933 Act or Section 20 of the 1934 Act against any and all loss, liability,
claim, damage and expense described in the indemnity contained in subsection (a)
of this Section, as incurred, but only with respect to untrue statements or
omissions, or


                                       20
<PAGE>

alleged untrue statements or omissions, made in the Registration Statement (or
any amendment thereto), including the Rule 430A Information and the Rule 434
Information, if applicable, or any preliminary U.S. prospectus or the U.S.
Prospectus (or any amendment or supplement thereto) in reliance upon and in
conformity with written information furnished to the Company by such U.S.
Underwriter through the U.S. Representative(s) expressly for use in the
Registration Statement (or any amendment thereto) or such preliminary prospectus
or the U.S. Prospectus (or any amendment or supplement thereto).

     (c) ACTIONS AGAINST PARTIES; NOTIFICATION. Each indemnified party shall
give notice as promptly as reasonably practicable to each indemnifying party of
any action commenced against it in respect of which indemnity may be sought
hereunder, but failure to so notify an indemnifying party shall not relieve such
indemnifying party from any liability hereunder to the extent it is not
materially prejudiced as a result thereof and in any event shall not relieve it
from any liability which it may have otherwise than on account of this indemnity
agreement. In the case of parties indemnified pursuant to Section 6(a) above,
counsel to the indemnified parties shall be selected by Merrill Lynch, and, in
the case of parties indemnified pursuant to Section 6(b) above, counsel to the
indemnified parties shall be selected by the Company. An indemnifying party may
participate at its own expense in the defense of any such action; PROVIDED,
HOWEVER, that counsel to the indemnifying party shall not (except with the
consent of the indemnified party) also be counsel to the indemnified party. In
no event shall the indemnifying parties be liable for fees and expenses of more
than one counsel (in addition to any local counsel) separate from their own
counsel for all indemnified parties in connection with any one action or
separate but similar or related actions in the same jurisdiction arising out of
the same general allegations or circumstances. No indemnifying party shall,
without the prior written consent of the indemnified parties, settle or
compromise or consent to the entry of any judgment with respect to any
litigation, or any investigation or proceeding by any governmental agency or
body, commenced or threatened, or any claim whatsoever in respect of which
indemnification or contribution could be sought under this Section 6 or Section
7 hereof (whether or not the indemnified parties are actual or potential parties
thereto), unless such settlement, compromise or consent (i) includes an
unconditional release of each indemnified party from all liability arising out
of such litigation, investigation, proceeding or claim and (ii) does not include
a statement as to or an admission of fault, culpability or a failure to act by
or on behalf of any indemnified party.

     (d) SETTLEMENT WITHOUT CONSENT IF FAILURE TO REIMBURSE. If at any time an
indemnified party shall have requested an indemnifying party to reimburse the
indemnified party for fees and expenses of counsel, such indemnifying party
agrees that it shall be liable for any settlement of the nature contemplated by
Section 6(a)(ii) effected without its written consent if (i) such settlement is
entered into more than 45 days after receipt by such indemnifying party of the
aforesaid request, (ii) such indemnifying party shall have received notice of
the terms of such settlement at least 30 days prior to such settlement being
entered into and (iii) such indemnifying party shall not have reimbursed such
indemnified party in accordance with such request prior to the date of such
settlement.



                                       21
<PAGE>

     SECTION 7. CONTRIBUTION. If the indemnification provided for in Section 6
hereof is for any reason unavailable to or insufficient to hold harmless an
indemnified party in respect of any losses, liabilities, claims, damages or
expenses referred to therein, then each indemnifying party shall contribute to
the aggregate amount of such losses, liabilities, claims, damages and expenses
incurred by such indemnified party, as incurred, (i) in such proportion as is
appropriate to reflect the relative benefits received by the Company on the one
hand and the U.S. Underwriters on the other hand from the offering of the
Securities pursuant to this Agreement or (ii) if the allocation provided by
clause (i) is not permitted by applicable law, in such proportion as is
appropriate to reflect not only the relative benefits referred to in clause (i)
above but also the relative fault of the Company on the one hand and of the U.S.
Underwriters on the other hand in connection with the statements or omissions
which resulted in such losses, liabilities, claims, damages or expenses, as well
as any other relevant equitable considerations.

     The relative benefits received by the Company on the one hand and the U.S.
Underwriters on the other hand in connection with the offering of the U.S.
Securities pursuant to this Agreement shall be deemed to be in the same
respective proportions as the total net proceeds from the offering of the U.S.
Securities pursuant to this Agreement (before deducting expenses) received by
the Company and the total underwriting discount received by the U.S.
Underwriters, in each case as set forth on the cover of the U.S. Prospectus, or,
if Rule 434 is used, the corresponding location on the Term Sheet, bear to the
aggregate initial public offering price of the U.S. Securities as set forth on
such cover.

     The relative fault of the Company on the one hand and the U.S. Underwriters
on the other hand shall be determined by reference to, among other things,
whether any such untrue or alleged untrue statement of a material fact or
omission or alleged omission to state a material fact relates to information
supplied by the Company or by the U.S. Underwriters and the parties' relative
intent, knowledge, access to information and opportunity to correct or prevent
such statement or omission.

     The Company and the U.S. Underwriters agree that it would not be just and
equitable if contribution pursuant to this Section were determined by pro rata
allocation (even if the U.S. Underwriters were treated as one entity for such
purpose) or by any other method of allocation which does not take account of the
equitable considerations referred to above in this Section. The aggregate amount
of losses, liabilities, claims, damages and expenses incurred by an indemnified
party and referred to above in this Section shall be deemed to include any legal
or other expenses reasonably incurred by such indemnified party in
investigating, preparing or defending against any litigation, or any
investigation or proceeding by any governmental agency or body, commenced or
threatened, or any claim whatsoever based upon any such untrue or alleged untrue
statement or omission or alleged omission.

     Notwithstanding the provisions of this Section, no U.S. Underwriter shall
be required to contribute any amount in excess of the amount by which the total
price at which the U.S. Securities underwritten by it and distributed to the
public were offered to the public exceeds the amount of any damages which such
U.S. Underwriter has otherwise been required to pay by reason of any such untrue
or alleged untrue statement or omission or alleged omission.

                                       22
<PAGE>

     No person guilty of fraudulent misrepresentation (within the meaning of
Section 11(f) of the 1933 Act) shall be entitled to contribution from any person
who was not guilty of such fraudulent misrepresentation.

     For purposes of this Section, each person, if any, who controls a U.S.
Underwriter within the meaning of Section 15 of the 1933 Act or Section 20 of
the 1934 Act shall have the same rights to contribution as such U.S.
Underwriter, and each director of the Company, each officer of the Company who
signed the Registration Statement, and each person, if any, who controls the
Company within the meaning of Section 15 of the 1933 Act or Section 20 of the
1934 Act shall have the same rights to contribution as the Company. The U.S.
Underwriters' respective obligations to contribute pursuant to this Section are
several in proportion to the number of Initial U.S. Securities set forth
opposite their respective names in Schedule A hereto and not joint.

     SECTION 8. REPRESENTATIONS, WARRANTIES AND AGREEMENTS TO SURVIVE DELIVERY.
All representations, warranties and agreements contained in this Agreement or in
certificates of officers of the Company or any of its subsidiaries submitted
pursuant hereto shall remain operative and in full force and effect, regardless
of any investigation made by or on behalf of any U.S. Underwriter or controlling
person, or by or on behalf of the Company, and shall survive delivery of the
Securities to the U.S. Underwriters.

     SECTION 9. TERMINATION OF AGREEMENT.

     (a) TERMINATION; GENERAL. The U.S. Representative(s) may terminate this
Agreement, by notice to the Company, at any time at or prior to Closing Time (i)
if there has been, since the time of execution of this Agreement or since the
respective dates as of which information is given in the U.S. Prospectus, any
material adverse change in the condition, financial or otherwise, or in the
earnings, business affairs or business prospects of the Company and its
subsidiaries considered as one enterprise, whether or not arising in the
ordinary course of business, or (ii) if there has occurred any material adverse
change in the financial markets in the United States or the international
financial markets, any outbreak of hostilities or escalation thereof or other
calamity or crisis or any change or development involving a prospective change
in national or international political, financial or economic conditions, in
each case the effect of which is such as to make it, in the judgment of the U.S.
Representatives, impracticable to market the Securities or to enforce contracts
for the sale of the Securities, or (iii) if trading in any securities of the
Company has been suspended or materially limited by the Commission or the Nasdaq
National Market, or if trading generally on the American Stock Exchange or the
New York Stock Exchange or in the Nasdaq National Market has been suspended or
materially limited, or minimum or maximum prices for trading have been fixed, or
maximum ranges for prices have been required, by any of said exchanges or by
such system or by order of the Commission, the National Association of
Securities Dealers, Inc. or any other governmental authority, or (iv) if a
banking moratorium has been declared by either Federal or New York authorities.

     (b) LIABILITIES. If this Agreement is terminated pursuant to this Section,
such termination shall be without liability of any party to any other party
except as provided in


                                       23
<PAGE>

Section 4 hereof, and provided further that Sections 1, 6, 7 and 8 shall survive
such termination and remain in full force and effect.

     SECTION 10. DEFAULT BY ONE OR MORE OF THE U.S. UNDERWRITERS. . If one or
more of the U.S. Underwriters shall fail at Closing Time or a Date of Delivery
to purchase the Securities which it or they are obligated to purchase under this
Agreement (the "Defaulted Securities"), the U.S. Representative(s) shall have
the right, within 24 hours thereafter, to make arrangements for one or more of
the non-defaulting U.S. Underwriters, or any other underwriters, to purchase
all, but not less than all, of the Defaulted Securities in such amounts as may
be agreed upon and upon the terms herein set forth; if, however, the U.S.
Representative(s) shall not have completed such arrangements within such 24-hour
period, then:

          (a) if the number of Defaulted Securities does not exceed 10% of the
     number of U.S. Securities to be purchased on such date, the non-defaulting
     U.S. Underwriters shall be obligated, each severally and not jointly, to
     purchase the full amount thereof in the proportions that their respective
     underwriting obligations hereunder bear to the underwriting obligations of
     all non-defaulting U.S. Underwriters, or

          (b) if the number of Defaulted Securities exceeds 10% of the number of
     U.S. Securities to be purchased on such date, this Agreement or, with
     respect to any Date of Delivery which occurs after Closing Time, the
     obligation of the U.S. Underwriters to purchase and of the Company to sell
     the Option Securities to be purchased and sold on such Date of Delivery
     shall terminate without liability on the part of any non-defaulting U.S.
     Underwriter.

     No action taken pursuant to this Section shall relieve any defaulting U.S.
Underwriter from liability in respect of its default.

     In the event of any such default which does not result in a termination of
this Agreement or, in the case of a Date of Delivery which is after Closing
Time, which does not result in a termination of the obligation of the U.S.
Underwriters to purchase and the Company to sell the relevant U.S. Option
Securities, as the case may be, either the U.S. Representative(s) or the Company
shall have the right to postpone Closing Time or the relevant Date of Delivery,
as the case may be, for a period not exceeding seven days in order to effect any
required changes in the Registration Statement or Prospectuses or in any other
documents or arrangements. As used herein, the term "U.S. Underwriter" includes
any person substituted for a U.S. Underwriter under this Section.



                                       24
<PAGE>

     SECTION 11. NOTICES. All notices and other communications hereunder shall
be in writing and shall be deemed to have been duly given if mailed or
transmitted by any standard form of telecommunication. Notices to the U.S.
Underwriters shall be directed to the U.S. Representatives at [3300 Hillview
Avenue, Suite 150, Palo Alto, California 94304], attention of D. Casey Safreno;
and notices to the Company shall be directed to it at 3030 Callan Road, San
Diego, California 92121, attention of Ken Woolcott.

     SECTION 12. PARTIES. This Agreement shall inure to the benefit of and be
binding upon the U.S. Underwriters and the Company and their respective
successors. Nothing expressed or mentioned in this Agreement is intended or
shall be construed to give any person, firm or corporation, other than the U.S.
Underwriters and the Company and their respective successors and the controlling
persons and officers and directors referred to in Sections 6 and 7 and their
heirs and legal representatives, any legal or equitable right, remedy or claim
under or in respect of this Agreement or any provision herein contained. This
Agreement and all conditions and provisions hereof are intended to be for the
sole and exclusive benefit of the U.S. Underwriters and the Company and their
respective successors, and said controlling persons and officers and directors
and their heirs and legal representatives, and for the benefit of no other
person, firm or corporation. No purchaser of Securities from any U.S.
Underwriter shall be deemed to be a successor by reason merely of such purchase.

     SECTION 13. GOVERNING LAW AND TIME. THIS AGREEMENT SHALL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. SPECIFIED TIMES
OF DAY REFER TO NEW YORK CITY TIME.

     SECTION 14. EFFECT OF HEADINGS. The Article and Section headings herein and
the Table of Contents are for convenience only and shall not affect the
construction hereof.



                                       25
<PAGE>

     If the foregoing is in accordance with your understanding of our agreement,
please sign and return to the Company a counterpart hereof, whereupon this
instrument, along with all counterparts, will become a binding agreement between
the U.S. Underwriters and the Company in accordance with its terms.

                                              Very truly yours,

                                              IDEC PHARMACEUTICALS CORPORATION

                                              By
                                                 ------------------------------
                                                 Title:

CONFIRMED AND ACCEPTED,
 as of the date first above written:

MERRILL LYNCH & CO.
MERRILL LYNCH, PIERCE, FENNER
  & SMITH INCORPORATED
SALOMON SMITH BARNEY, INC.
BANC OF AMERICA SECURITIES LLC

BY:  MERRILL LYNCH, PIERCE,
     FENNER & SMITH INCORPORATED

By
   ---------------------------------
          Authorized Signatory

For themselves and as U.S. Representatives of
the other U.S. Underwriters named in Schedule
A hereto.



                                       26
<PAGE>

<TABLE>
<CAPTION>



                                   SCHEDULE A

                            List of U.S. Underwriters

NAME OF U.S. UNDERWRITER                                                         NUMBER OF INITIAL U.S.
------------------------                                                                SECURITIES
                                                                                 ----------------------

<S>                                                                                     <C>
Merrill Lynch, Pierce, Fenner & Smith Incorporated............................

Salomon Smith Barney, Inc.....................................................

Banc of America Securities LLC................................................          ---------------

Total.........................................................................                1,600,000
                                                                                        ===============
</TABLE>



















                                    Sch A-1
<PAGE>







                                   SCHEDULE B

                               Pricing Information

                        IDEC PHARMACEUTICALS CORPORATION

                        1,600,000 Shares of Common Stock

                          (Par Value $0.0005 Per Share)

     1. The initial public offering price per share for the Securities,
determined as provided in said Section 2, shall be $.

     2. The purchase price per share for the U.S. Securities to be paid by the
several U.S. Underwriters shall be $o, being an amount equal to the initial
public offering price set forth above less $o per share; provided that the
purchase price per share for any U.S. Option Securities purchased upon the
exercise of the over-allotment option described in Section 2(b) shall be reduced
by an amount per share equal to any dividends or distributions declared by the
Company and payable on the Initial U.S. Securities but not payable on the U.S.
Option Securities.


















                                    Sch B-1
<PAGE>






                                   SCHEDULE C

                [List of Persons and Entities Subject to Lock-Up]





















                                    Sch C-1
<PAGE>





                                                                       Exhibit A

                      FORM OF OPINION OF COMPANY'S COUNSEL
                    TO BE DELIVERED PURSUANT TO SECTION 5(b)

     (i) The Company has been duly incorporated and is validly existing as a
corporation in good standing under the laws of the State of Delaware.

     (ii) The Company has corporate power and corporate authority to own, lease
and operate its properties and to conduct its business as described in the
Prospectuses and to enter into and perform its obligations under the U.S.
Purchase Agreement and the International Purchase Agreement.

     (iii) The Company is duly qualified as a foreign corporation in the United
States to transact business and is in good standing in each jurisdiction in the
United States in which such qualification is required, whether by reason of the
ownership or leasing of property or the conduct of business, except where the
failure so to qualify or to be in good standing would not result in a Material
Adverse Effect.

     (iv) To our knowledge, the authorized, issued and outstanding capital stock
of the Company is as set forth in the Prospectuses in the column entitled
"Actual" under the caption "Capitalization" (except for subsequent issuances, if
any, pursuant to the U.S. Purchase Agreement and the International Purchase
Agreement or pursuant to reservations, agreements or employee benefit plans or
pursuant to the exercise of convertible securities or options referred to in the
Prospectuses); the shares of issued and outstanding capital stock of the Company
have been duly authorized and validly issued and are fully paid and
non-assessable; and none of the outstanding shares of capital stock of the
Company was issued in violation of the preemptive or other similar rights of any
securityholder of the Company.

     (v) The Securities to be purchased by the U.S. Underwriters and the
International Managers from the Company have been duly authorized for issuance
and sale to the Underwriters pursuant to the U.S. Purchase Agreement and the
International Purchase Agreement, respectively, and, when issued and delivered
by the Company pursuant to the U.S. Purchase Agreement and the International
Purchase Agreement, respectively, against payment of the consideration set forth
in the U.S. Purchase Agreement and the International Purchase Agreement, will be
validly issued and fully paid and non-assessable and no holder of the Securities
is or will be subject to personal liability by reason of being such a holder.

     (vi) The issuance of the Securities is not subject to the preemptive or
other similar rights of any securityholder of the Company.

     (vii) [Each Subsidiary has been duly incorporated and is validly existing
as a corporation in good standing under the laws of the jurisdiction of its
incorporation, has corporate power and authority to own, lease and operate its
properties and to conduct its business as described in the Prospectuses and is
duly qualified as a foreign corporation to transact business



                                   A-1
<PAGE>

and is in good standing in each jurisdiction in which such qualification is
required, whether by reason of the ownership or leasing of property or the
conduct of business, except where the failure so to qualify or to be in good
standing would not result in a Material Adverse Effect; except as otherwise
disclosed in the Registration Statement, all of the issued and outstanding
capital stock of each Subsidiary has been duly authorized and validly issued, is
fully paid and non-assessable and, to the best of our knowledge, is owned by the
Company, directly or through subsidiaries, free and clear of any security
interest, mortgage, pledge, lien, encumbrance, claim or equity; none of the
outstanding shares of capital stock of any Subsidiary was issued in violation of
the preemptive or similar rights of any securityholder of such Subsidiary.] [To
the best of our knowledge, the Company does not have any subsidiaries.]

     (viii) The U.S. Purchase Agreement and the International Purchase Agreement
have been duly authorized, executed and delivered by the Company.

     (ix) The Registration Statement, including any Rule 462(b) Registration
Statement, has been declared effective under the 1933 Act; any required filing
of the Prospectuses pursuant to Rule 424(b) has been made in the manner and
within the time period required by Rule 424(b); and, to the best of our
knowledge, no stop order suspending the effectiveness of the Registration
Statement or any Rule 462(b) Registration Statement has been issued under the
1933 Act and no proceedings for that purpose have been instituted or are pending
or threatened by the Commission.

     (x) The Registration Statement, including any Rule 462(b) Registration
Statement, the Rule 430A Information and the Rule 434 Information, as
applicable, the Prospectuses, excluding the documents incorporated by reference
therein, and each amendment or supplement to the Registration Statement and
Prospectuses, excluding the documents incorporated by reference therein, as of
their respective effective or issue dates (other than the financial statements
and supporting schedules included therein or omitted therefrom, as to which we
need express no opinion) complied as to form in all material respects with the
requirements of the 1933 Act and the 1933 Act Regulations.

     (xi) The documents incorporated by reference in the Prospectuses (other
than the financial statements and supporting schedules included therein or
omitted therefrom, as to which we need express no opinion), when they were filed
with the Commission, complied as to form in all material respects with the
requirements of the 1934 Act and the rules and regulations of the Commission
thereunder.

     (xii) The form of certificate used to evidence the Common Stock complies in
all material respects with all applicable statutory requirements, with any
applicable requirements of the charter and by-laws of the Company and the
requirements of the Nasdaq National Market.

     (xiii) There is not pending or, to the best of our knowledge, threatened
any action, suit, proceeding, inquiry or investigation, to which the Company or
any subsidiary is a party, or to which the property of the Company or any
subsidiary is subject, before or brought by any United States federal or
California or New York state court or governmental agency or body which might
reasonably be expected to result in a Material Adverse Effect, or which might
reasonably be expected to materially and adversely affect the properties or
assets thereof or the





                                      A-2
<PAGE>

consummation of the transactions contemplated in the U.S. Purchase Agreement and
International Purchase Agreement or the performance by the Company of its
obligations thereunder or the transactions contemplated by the Prospectuses.

     (xiv) The information in the Prospectuses under "Description of Capital
Stock", "Business--Litigation", "Material United States Federal Tax Consequences
to Non-United States Holders", and "o" and in the Registration Statement under
Item 15, to the extent that it constitutes matters of law, summaries of legal
matters, the Company's charter and by-laws or legal proceedings, or legal
conclusions, has been reviewed by us and is correct in all material respects.

     (xv) To the best of our knowledge, there are no statutes or regulations
that are required to be described in the Prospectuses that are not described as
required.

     (xvi) All descriptions in the Registration Statement of contracts and other
documents to which the Company or its subsidiaries are a party are accurate in
all material respects; to our knowledge, there are no franchises, contracts,
indentures, mortgages, loan agreements, notes, leases or other instruments that
would be required to be described in the Registration Statement or to be filed
as exhibits thereto that are not described or referred to in the Prospectuses
other than those described or referred to therein or filed or incorporated by
reference as exhibits thereto, and the descriptions thereof or references
thereto are correct in all material respects.

     (xvii) To our knowledge, neither the Company nor any subsidiary is in
violation of its charter or by-laws and no default by the Company or any
subsidiary exists in the due performance or observance of any material
obligation, agreement, covenant or condition contained in any contract,
indenture, mortgage, loan agreement, note, lease or other agreement or
instrument that is described or referred to in the Registration Statement or the
Prospectuses or filed or incorporated by reference as an exhibit to the
Registration Statement.

     (xviii) No filing with, or authorization, approval, consent, license,
order, registration, qualification or decree of, any United States federal or
California state court or New York state court or governmental authority or
agency (other than under the 1933 Act and the 1933 Act Regulations, which have
been obtained, or as may be required under the securities or blue sky laws of
the various states, as to which we need express no opinion) is necessary or
required in connection with the due authorization, execution and delivery of the
U.S. Purchase Agreement and the International Purchase Agreement or for the
offering, issuance, sale or delivery of the Securities.

     (xix) The execution, delivery and performance of the U.S. Purchase
Agreement and the International Purchase Agreement and the consummation of the
transactions contemplated in the U.S. Purchase Agreement, the International
Purchase Agreement and in the Registration Statement (including the issuance and
sale of the Securities and the use of the proceeds from the sale of the
Securities as described in the Prospectuses under the caption "Use Of Proceeds")
and compliance by the Company with its obligations under the U.S. Purchase
Agreement and the International Purchase Agreement do not and will not, whether
with or without the giving of notice or lapse of time or both, conflict with or
constitute a breach of, or default or Repayment Event (as defined in Section
1(a)(xi) of the Purchase Agreements) under, or result in the creation






                                      A-3
<PAGE>

or imposition of any lien, charge or encumbrance upon any property or assets of
the Company or any subsidiary pursuant to, any contract, indenture, mortgage,
deed of trust, loan or credit agreement, note, lease or any other agreement or
instrument filed as an exhibit to any 1934 Act filing or incorporated by
reference in the Prospectuses [or on the attached Schedule A], to which the
Company or any of its subsidiaries is a party or by which it or any of them may
be bound, or to which any of the property or assets of the Company or any
subsidiary thereof is subject (except for such conflicts, breaches or defaults
or liens, charges or encumbrances that would not have a Material Adverse
Effect), nor will such action result in any violation of the provisions of the
charter or by-laws of the Company or any of its subsidiaries, or any applicable
United States federal or California state law or New York state law, statute,
rule, regulation, judgment, order, writ or decree, known to us, of any United
States federal or California or New York state government instrumentality or
court having jurisdiction over the Company or any of its subsidiaries or any of
their respective properties, assets or operations.

     (xx) The Company is not an "investment company" or an entity "controlled"
by an "investment company", as such terms are defined in the 1940 Act.

     Nothing has come to our attention that would lead us to believe that the
Registration Statement or any amendment thereto, including the Rule 430A
Information and Rule 434 Information (if applicable), (except for financial
statements and schedules and other financial data included or incorporated by
reference therein or omitted therefrom, as to which we need make no statement),
at the time such Registration Statement or any such amendment became effective,
contained an untrue statement of a material fact or omitted to state a material
fact required to be stated therein or necessary to make the statements therein
not misleading or that the Prospectuses or any amendment or supplement thereto
(except for financial statements and schedules and other financial data included
or incorporated by reference therein or omitted therefrom, as to which we need
make no statement), at the time the Prospectuses were issued, at the time any
such amended or supplemented prospectus was issued or at the Closing Time,
included or includes an untrue statement of a material fact or omitted or omits
to state a material fact necessary in order to make the statements therein, in
the light of the circumstances under which they were made, not misleading.

     In rendering such opinion, such counsel may rely, as to matters of fact
(but not as to legal conclusions), to the extent they deem proper, on
certificates of responsible officers of the Company and public officials. Such
opinion shall not state that it is to be governed or qualified by, or that it is
otherwise subject to, any treatise, written policy or other document relating to
legal opinions, including, without limitation, the Legal Opinion Accord of the
ABA Section of Business Law (1991).














                                      A-4
<PAGE>







                                                                       Exhibit B

                               FORM OF OPINION OF
                      COMPANY'S REGULATORY AFFAIRS COUNSEL


























                                      B-1
<PAGE>







                                                                       Exhibit C

                               FORM OF OPINION OF
                     COMPANY'S INTELLECTUAL PROPERTY COUNSEL






















                                      C-1
<PAGE>







[FORM OF LOCK-UP FROM DIRECTORS, OFFICERS OR OTHER STOCKHOLDERS PURSUANT TO
SECTION 5(k)]

                                                                       Exhibit D

                                                                November o, 2000

MERRILL LYNCH & CO.
Merrill Lynch, Pierce, Fenner & Smith Incorporated
Salomon Smith Barney, Inc.
Banc of America Securities LLC
as Representatives of the several U.S. Underwriters to be
  named in the within-mentioned U.S. Purchase Agreement
c/o  Merrill Lynch & Co.
     Merrill Lynch, Pierce, Fenner & Smith Incorporated
     North Tower
     World Financial Center
     New York, New York  10281

         Re:      PROPOSED PUBLIC OFFERING BY IDEC PHARMACEUTICALS CORPORATION

Dear Sirs:

     The undersigned, a stockholder and an officer and/or director of IDEC
Pharmaceuticals Corporation, a Delaware corporation (the "Company"), understands
that Merrill Lynch & Co., Merrill Lynch, Pierce, Fenner & Smith Incorporated
("Merrill Lynch"), Merrill Lynch International, and Salomon Smith Barney, Inc.
and Banc of America Securities LLC propose to enter into a U.S. Purchase
Agreement an International Purchase Agreement (collectively, the "Purchase
Agreements") with the Company providing for the public offering of shares (the
"Offering") of the Company's common stock, par value $0.0005 per share (the
"Common Stock"). In recognition of the benefit that such an offering will confer
upon the undersigned as a stockholder and an officer and/or director of the
Company, and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the undersigned agrees with each
underwriter to be named in the Purchase Agreements that, during a period of 90
days from the date of the earlier of the two Purchase Agreements, the
undersigned will not, without the prior written consent of Merrill Lynch,
directly or indirectly, (i) offer, pledge, sell, contract to sell, sell any
option or contract to purchase, purchase any option or contract to sell, grant
any option, right or warrant for the sale of, or otherwise dispose of or
transfer any shares of the Company's Common Stock or any securities convertible
into or exchangeable or exercisable for Common Stock, whether now owned or
hereafter acquired by the undersigned or with respect to which the undersigned
has or hereafter acquires the power of disposition, or file any registration
statement under the Securities Act of 1933, as amended, with respect to any of
the foregoing or (ii) enter into any swap or any other agreement or any
transaction that transfers, in whole or in part, directly or indirectly, the
economic consequence of ownership of the Common Stock, whether any such swap or
transaction is to be settled by delivery of Common Stock or other securities, in
cash or otherwise.

     Notwithstanding any other provision of this letter, this letter and all
obligations of the undersigned hereunder, shall terminate automatically and be
of no further force and effect in the event that the Offering does not close by
March 31, 2001.

                                      D-1
<PAGE>

                                               Very truly yours,

                                               Signature:
                                                         ---------------------

                                               Print Name:
                                                         ---------------------











                                      D-2
<PAGE>







                                                                         Annex A

          [FORM OF ACCOUNTANTS' COMFORT LETTER PURSUANT TO SECTION 5(e)]

     [We are independent public accountants with respect to the Company within
the meaning of the 1933 Act and the applicable published 1933 Act Regulations]

          (i) in our opinion, the audited financial statements [and the related
     financial statement schedules] included or incorporated by reference in the
     Registration Statement and the Prospectuses comply as to form in all
     material respects with the applicable accounting requirements of the 1933
     Act and the 1934 Act and the published rules and regulations thereunder;

          (ii) on the basis of procedures (but not an examination in accordance
     with generally accepted auditing standards) consisting of a reading of the
     unaudited interim [consolidated] financial statements of the Company for
     the [three month periods ended _________, 20___ and _________, 20___, the
     three and six month periods ended _________, 20___ and _________, 20___ and
     the three and nine month periods ended _________, 20___ and _________,
     20___, included or incorporated by reference in the Registration Statement
     and the Prospectuses (collectively, the "10-Q Financials")] [, a reading of
     the unaudited interim [consolidated] financial statements of the Company
     for the _____-month periods ended _________, 20___ and _________, 20___,
     included in the Registration Statement and the Prospectuses (the
     "____-month financials")] [, a reading of the latest available unaudited
     interim [consolidated] financial statements of the Company], a reading of
     the minutes of all meetings of the stockholders and directors of the
     Company [and its subsidiaries] and the _____________ and ____________
     Committees of the Company's Board of Directors [and any subsidiary
     committees] since [day after end of last audited period], inquiries of
     certain officials of the Company [and its subsidiaries] responsible for
     financial and accounting matters, a review of interim financial information
     in accordance with standards established by the American Institute of
     Certified Public Accountants in Statement on Auditing Standards No. 71,
     Interim Financial Information ("SAS 71"), with respect to the [description
     of relevant periods] and such other inquiries and procedures as may be
     specified in such letter, nothing came to our attention that caused us to
     believe that:

               [(A) the 10-Q Financials incorporated by reference in the
          Registration Statement and the Prospectuses do not comply as to
          form in all material respects with the applicable accounting
          requirements of the 1934 Act and the 1934 Act Regulations
          applicable to unaudited financial statements included in Form 10-Q
          or any material modifications should be made to the 10-Q
          Financials incorporated by reference in the Registration Statement
          and the Prospectuses for them to be in conformity with generally
          accepted accounting principles;]

               [( ) the _____-month financials included in the Registration
          Statement and the Prospectuses do not comply as to form in all
          material respects with the


                                  Annex A-1
<PAGE>

          applicable accounting requirements of the 1933 Act and the 1933 Act
          Regulations applicable to unaudited interim financial statements
          included in registration statements or any material modifications
          should be made to the _____-month financials included in the
          Registration Statement and the Prospectuses for them to be in
          conformity with generally accepted accounting principles;]

               ( ) at [_________, 20___ and at] a specified date not more
          than           five days prior to the date of this Agreement, there
          was any change in the ___________ of the Company
          [and its subsidiaries] or any decrease in the __________ of the
          Company [and its subsidiaries] or any increase in the __________ of
          the Company [and its subsidiaries,] in each case as compared with
          amounts shown in the latest balance sheet included or incorporated
          by reference in the Registration Statement, except in each case for
          changes, decreases or increases that the Registration Statement
          discloses have occurred or may occur; or

               ( ) [for the period from _________, 20___ to _________, 20___
          and] for the period from _________, 20___ to a specified date not
          more than five days prior to the date of this Agreement, there was
          any decrease in _________, __________ or ___________, in each case
          as compared with the comparable period in the preceding year,
          except in each case for any decreases that the Registration
          Statement discloses have occurred or may occur;

          (iii) based upon the procedures set forth in clause (ii) above and a
     reading of the [Selected Financial Data] included in the Registration
     Statement [and a reading of the financial statements from which such data
     were derived], nothing came to our attention that caused us to believe that
     the [Selected Financial Data] included in the Registration Statement do not
     comply as to form in all material respects with the disclosure requirements
     of Item 301 of Regulation S-K of the 1933 Act [, that the amounts included
     in the [Selected Financial Data] are not in agreement with the
     corresponding amounts in the audited [consolidated] financial statements
     for the respective periods or that the financial statements not included
     in the Registration Statement from which certain of such data were derived
     are not in conformity with generally accepted accounting principles];

          (iv) we have compared the information in the Registration Statement
     under selected captions with the disclosure requirements of Regulation
     S-K of the 1933 Act and on the basis of limited procedures specified
     herein, nothing came to our attention that caused us to believe that
     this information does not comply as to form in all material respects
     with the disclosure requirements of
     [Items 302, 402 and 503(d), respectively,] of Regulation S-K;

          (v) [based upon the procedures set forth in clause (ii) above, a
     reading of the unaudited financial statements of the Company for
     [the most recent period]that have not been included in the Registration
     Statement and a review of such financial statements in accordance with
     SAS 71, nothing came to our attention that caused us to believe that the
     unaudited amounts for _____________ for the [most recent period] do not
     agree with the amounts set forth in the unaudited consolidated financial
     statements for those periods or


                                  Annex A-2
<PAGE>

     that such unaudited amounts were not determined on a basis substantially
     consistent with that of the corresponding amounts in the audited
     [consolidated]financial statements;]

          (vi) [we are unable to and do not express any opinion on the [Pro
     Forma Combining Statement of Operations] (the "Pro Forma Statement")
     included in the Registration Statement or on the pro forma adjustments
     applied to the historical amounts included in the Pro Forma Statement;
     however, for purposes of this letter we have:

               (A) read the Pro Forma Statement;

               (B) performed [an audit] [a review in accordance with SAS 71]
          of the financial statements to which the pro forma adjustments were
          applied;

               (C) made inquiries of certain officials of the Company who have
          responsibility for financial and accounting matters about the basis
          for their determination of the pro forma adjustments and whether the
          Pro Forma Statement complies as to form in all material respects with
          the applicable accounting requirements of Rule 11-02 of
          Regulation S-X; and

               (D) proved the arithmetic accuracy of the application of the pro
          forma adjustments to the historical amounts in the Pro Forma
          Statement; and]

     on the basis of such procedures and such other inquiries and procedures
     as specified herein, nothing came to our attention that caused us to
     believe that the Pro Forma Statement included in the Registration
     Statement does not comply as to form in all material respects with the
     applicable requirements of Rule 11-02 of Regulation S-X or that the pro
     forma adjustments have not been properly applied to the historical
     amounts in the compilation of those statements; and]

          (vii) [in addition to the procedures referred to in clause (ii) above,
     we have performed other procedures, not constituting an audit, with
     respect to certain amounts, percentages, numerical data and financial
     information appearing in the Registration Statement, which are specified
     herein, and have compared certain of such items with, and have found
     such items to be in agreement with, the accounting and financial records
     of the Company;] and

          (viii) [in addition, we [comfort on a financial forecast that is
     included in the Registration Statement].


                               Annex A-3


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