VERTEX PHARMACEUTICALS INC / MA
S-8, 1996-09-19
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1
 As filed with the Securities and Exchange Commission on September 19, 1996

                                                  Registration No. 333-_________

- --------------------------------------------------------------------------------

                     SECURITIES AND EXCHANGE COMMISSION
                           Washington, D.C. 20549

                                  FORM S-8

                           REGISTRATION STATEMENT
                                  under the
                           SECURITIES ACT OF 1933

                     VERTEX PHARMACEUTICALS INCORPORATED
           ------------------------------------------------------
           (Exact name of registrant as specified in its charter)

          Massachusetts                                 04-3039129
- ----------------------------------------    ------------------------------------
(State of incorporation or organization)    (I.R.S. Employer Identification No.)

               130 Waverly Street, Cambridge, Massachusetts 02139
               --------------------------------------------------
                    (Address of Principal Executive Offices)

                       Vertex Pharmaceuticals Incorporated
                          EMPLOYEE STOCK PURCHASE PLAN
                          ----------------------------
                            (Full title of the plan)

                Joshua Boger, President & Chief Executive Officer
                       Vertex Pharmaceuticals Incorporated
                               130 Waverly Street
                            Cambridge, MA 02139-4242
                            ------------------------
                     (Name and address of agent for service)

                                 (617) 577-6000
          -------------------------------------------------------------
          (Telephone number, including area code, of agent for service)
<TABLE>
                                         CALCULATION OF REGISTRATION FEE
==================================================================================================================
<CAPTION>
                                                 Proposed Maximum        Proposed Maximum
Title of Securities          Amount to be        Offering Price          Aggregate                Amount of
to be Registered             Registered (1)      Per Share (2)           Offering Price (2)       Registration Fee
- -----------------            --------------      -------------           ------------------       ----------------
<S>                             <C>                  <C>                     <C>                      <C>
Common Stock, par
value, $.01 per share           150,000              $33.31                   $4,996,500               $1,723

Rights to purchase
Series A Junior Participating
Preferred Stock                      (3)                 (3)                          (3)                None
- ------------------------------------------------------------------------------------------------------------------
<FN>

(1)  Together with an indeterminate number of additional shares which may result from a stock split, stock dividend, 
     or other similar adjustment of the outstanding shares of Common Stock.

(2)  Computed solely for the purpose of calculating the registration fee on the basis of the average of the high and 
     low prices per share of the Registrant's Common Stock on the Nasdaq National Market System as of a date 
     (September 17, 1996) within five (5) business days prior to filing this Registration Statement.

(3)  No separate consideration will be received for the Rights.
</TABLE>

<PAGE>   2


  Statement Regarding Incorporation By Reference From Effective Registration
  --------------------------------------------------------------------------
                                Statement
                                ---------

     Pursuant to Instruction E to Form S-8, the contents of Items 3 through 7
and 9 of the Registrant's Registration Statement on Form S-8 filed with the
S.E.C. on June 4, 1992 (Registration No. 33-48348) are incorporated by reference
in this Registration Statement. For Item 8, see the Exhibit Index immediately
following the signature page of this Registration Statement.

                                    -Page 2-
<PAGE>   3


                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in Cambridge, Massachusetts, on September 19, 1996.

                                       VERTEX PHARMACEUTICALS INCORPORATED


                                       By: /s/ Joshua S. Boger
                                           -------------------------------------
                                           Joshua S. Boger
                                           President and Chief Executive Officer


     KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears
below constitutes and appoints Joshua S. Boger, Richard H. Aldrich, and Thomas
G. Auchincloss, Jr., and each of them, his true and lawful attorneys-in-fact and
agents, with full power of substitution and resubstitution in each of them, for
him and in his name, place and stead, and in any and all capacities, to sign any
and all amendments (including post-effective amendments) to this Registration
Statement, and to file the same, with all exhibits thereto and other documents
in connection therewith, with the Securities and Exchange Commission, granting
unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite or necessary
to be done in and about the premises, as fully to all intents and purposes as he
might or could do in person, hereby ratifying and confirming all that said
attorneys-in-fact and agents or any of them or their or his substitute or
substitutes may lawfully do or cause to be done by virtue hereof.
<TABLE>
     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.
<S>                                 <C>                                         <C>
/s/ Joshua S. Boger                 Director, President and                     September 19, 1996
- ---------------------------------   Chief Executive Officer                     ------------
Joshua S. Boger                     (Principal Executive Officer) 

/s/ Thomas G. Auchincloss, Jr.      Senior Director of Finance and              September 19, 1996
- ---------------------------------   Treasurer (Principal Financial Officer)     ------------
Thomas G. Auchincloss, Jr.         

/s/ Hans D. Van Houte               Controller                                  September 19, 1996
- ---------------------------------                                               ------------
Hans D. Van Houte

/s/ Barry M. Bloom                  Director                                    September 19, 1996
- ---------------------------------                                               ------------
Barry M. Bloom

/s/ Roger W. Brimblecombe           Director                                    September 19, 1996
- ---------------------------------                                               ------------
Roger W. Brimblecombe

/s/ Donald R. Conklin               Director                                    September 19, 1996
- ---------------------------------                                               ------------
Donald R. Conklin

/s/ William W. Helman IV            Director                                    September 19, 1996
- ---------------------------------                                               ------------
William W. Helman IV

/s/ Benno C. Schmidt                Director                                    September 19, 1996
- ---------------------------------                                               ------------
Benno C. Schmidt

</TABLE>
                                    -Page 3-

<PAGE>   4


                                   EXHIBITS


Exhibit No.                      Description
- -----------                      -----------

(4.1)   Specimen Common Stock Certificate (filed as Exhibit 4.1 to the
        Registration Statement on Form S-1, Registration No. 33-40966, as
        amended, and incorporated herein by reference)

(4.2)   Stockholder Rights Plan (filed as Exhibit 4.2 to the Registration
        Statement on Form S-1, Registration No. 33-40966, as amended, and
        incorporated herein by reference)

(5)     Opinion of Warner & Stackpole LLP (filed herewith at page 5)

(23.1)  Consent of Coopers & Lybrand LLP (filed herewith at page 7)

(23.2)  Consent of Warner & Stackpole LLP (included in Exhibit 5)

(24)    Power of Attorney to file future amendments (included on the signature
        page of this Registration Statement)

(99.1)  Amendment to the Company's Employee Stock Purchase Plan approved by the
        Stockholders on May 9, 1996 (filed herewith at page 8).


                                    -Page 4-


<PAGE>   1
                                  EXHIBIT 5



75 State Street              WARNER & STACKPOLE LLP    Telephone: (617) 951-9000
Boston, Massachusetts 02109  ----------------------          Fax: (617) 951-9151
                               COUNSELLORS AT LAW




                                                     September 19, 1996


Vertex Pharmaceuticals Incorporated
130 Waverly Street
Cambridge, MA  02139-4211

Ladies and Gentlemen:

     We have acted as counsel to Vertex Pharmaceuticals Incorporated, a
Massachusetts corporation (the "Company"), in connection with the preparation
and filing with the Securities and Exchange Commission of a Registration
Statement on Form S-8 (the "Registration Statement") with respect to the
offering by the Company of 150,000 shares (the "Shares") of the Common Stock,
$.01 par value per share, of the Company pursuant to the Vertex Pharmaceuticals
Incorporated Employee Stock Purchase Plan (the "Plan"), and the proposed
issuance by the Company in connection therewith of rights to purchase Series A
Junior Participating Preferred Stock, $.01 par value per share (the "Rights").

     We have examined (i) the Registration Statement, (ii) the Restated Articles
of Organization of the Company, (iii) the Rights Agreement (the "Rights Plan")
under which the Rights are proposed to be issued, and such other documents an
records of the Company as we have deemed necessary for the purpose of this
opinion.

     In our examination of the foregoing documents, we have assumed the
genuineness of all signatures and the authenticity of all documents submitted to
us as originals, the conformity to original documents of all documents submitted
to us as certified or photostatic copies, and the authenticity of the originals
of such latter documents.

     We are members of the bar of the Commonwealth of Massachusetts and we
express no opinion as to any matters insofar as any laws other than Federal laws
and laws of the Commonwealth of Massachusetts may be applicable.

     We assume that appropriate action will be taken, prior to the offer and
sale of the Shares, to register and qualify the Shares and the Rights for sale
under all applicable state securities or "blue sky" laws.

     Based upon the foregoing, we are of the opinion that the Shares and the
Rights are duly authorized for issuance, and upon (i) the effectiveness of the
Registration Statement, (ii) payment


                                  -Page 5-
<PAGE>   2

                           WARNER & STACKPOLE LLP
                           ----------------------

Vertex Pharmaceuticals Incorporated
September 19, 1996
Page 2


for the Shares in accordance with the terms of the Plan, (iii) the issuance of
certificates therefor by the Company, and (iv) as to the Rights only, the
issuance of the Rights in accordance with the terms of the Rights Plan, the
Shares and the Rights will be validly issued, fully paid and non-assessable.

     We hereby consent to the filing of this opinion as an exhibit to the
Registration Statement.


                                                     Very truly yours


                                                     /s/ Warner & Stackpole LLP


                                    -Page 6-

<PAGE>   1
                                EXHIBIT 23.1

                     CONSENT OF INDEPENDENT ACCOUNTANTS


     We consent to the incorporation by reference in this registration statement
of Vertex Pharmaceuticals Incorporated on Form S-8 to register 150,000 shares of
common stock of the Employee Stock Purchase Plan of our report dated February
22, 1996 on our audit of the consolidated financial statements of Vertex
Pharmaceuticals Incorporated and Subsidiaries as of December 31, 1995 and 1994,
and for each of the three years in the period ended December 31, 1995, which
report was included in the 1995 Annual Report of Vertex Pharmaceuticals
Incorporated on Form 10-K.



                                              COOPERS & LYBRAND L.L.P.

Boston, Massachusetts
September 19, 1996





                                  -Page 7-

<PAGE>   1
                                EXHIBIT 99.1




              Amendment to Vertex Pharmaceuticals Incorporated
              ------------------------------------------------
                        Employee Stock Purchase Plan
                        ----------------------------
                 Approved by the Stockholders on May 9, 1996
                 -------------------------------------------


SECTION 3.1 is hereby amended by deleting such section in its entirety and
substituting therefor the following:


         SECTION 3.1. Reservation of Common Stock. The Board of Directors shall
reserve three hundred thousand (300,000) shares of Common Stock for the Plan,
subject to adjustment in accordance with Section 3.4.


As so amended, the Plan shall continue in full force and effect in accordance
with its terms.


                                  -Page 8-


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