VERTEX PHARMACEUTICALS INC / MA
424B3, 2000-09-29
PHARMACEUTICAL PREPARATIONS
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<PAGE>

Filed Pursuant to Rule 424(b)(3)
                                                    REGISTRATION NO. 333-37794

           PROSPECTUS SUPPLEMENT NO. 4 DATED SEPTEMBER 29, 2000 TO THE
                       PROSPECTUS DATED AUGUST 1, 2000 OF
                       VERTEX PHARMACEUTICALS INCORPORATED

This Prospectus Supplement No. 4 amends the information in the table under
the caption "Selling Holders" in the Prospectus dated August 1, 2000, as
previously amended, by deleting the information contained in the table
regarding the Selling Security Holders with respect to the principal amount
of notes and common stock of Vertex Pharmaceuticals Incorporated and
substituting therefor the following table:

<TABLE>
<CAPTION>
                                                                                               NUMBER OF SHARES OF
                                                                                              COMMON STOCK ISSUABLE
                                                       PRINCIPAL AMOUNT OF NOTES              UPON CONVERSION OF THE
                                                           BENEFICIALLY OWNED                    NOTES THAT MAY BE
  NAME OF SECURITY HOLDER                                    AND OFFERED(1)                         OFFERED(2)
  -----------------------                              -------------------------              ----------------------
<S>                                                    <C>                                    <C>
The Adams Express Company                                     $10,000,000                            248,015

AIG SoundShore Holdings Ltd.                                   $1,670,000                             41,418

AIG SoundShore Opportunity Holding
Fund Ltd.                                                      $2,400,000                             59,523

AIG SoundShore Strategic Holding
Fund Ltd.                                                      $1,400,000                             34,722

Alexandra Global Investment Fund 1 Ltd.                        $3,000,000                             74,404

Alta Partners Holdings, Inc. (3)                               $5,000,000                            124,007

American Masters Fund "AG Absolute
Return Series" Limited                                         $1,000,000                             24,801

Angelo, Gordon & Co., L.P.                                       $500,000                             12,400

Argent Classic Convertible Arbitrage
Fund (Bermuda) L.P.                                            $5,000,000                            124,007

Bear, Stearns & Co. Inc.(4)                                      $500,000                             12,400

BNP Arbitrage SNC                                              $6,500,000                            161,210

Boulder II Limited                                             $5,000,000                            124,007

BP Amoco PLC Master Trust                                      $2,200,000                             54,563

BT Equity Opportunities                                        $1,000,000                             24,801

BT Equity Strategies                                           $1,000,000                             24,801

CFFX, LLC                                                      $3,250,000                             80,605

CIBC World Markets                                             $3,250,000                             80,605

Credit Suisse First Boston Corporation                         $3,800,000                             94,246

The Common Fund F/A/O Absolute
Return Fund                                                      $300,000                              7,440

</TABLE>

                                      -1-

<PAGE>

<TABLE>
<CAPTION>
                                                                                               NUMBER OF SHARES OF
                                                                                              COMMON STOCK ISSUABLE
                                                       PRINCIPAL AMOUNT OF NOTES              UPON CONVERSION OF THE
                                                           BENEFICIALLY OWNED                    NOTES THAT MAY BE
  NAME OF SECURITY HOLDER                                    AND OFFERED(1)                         OFFERED(2)
  -----------------------                              -------------------------              ----------------------
<S>                                                    <C>                                    <C>

Deutsche Bank Securities                                       $4,900,000                            121,527

Donaldson, Lufkin & Jenrette
Securities Corp.                                                 $500,000                             12,400

Estate of James Campbell                                         $950,000                             23,561

First Albany Corporation                                         $111,000                              2,752

Grace Brothers, Ltd.                                           $1,500,000                             37,202

Helix Convertible Opportunities Fund Ltd                         $910,000                             22,569

Helix Convertible Opportunities, L.P.                          $1,790,000                             44,394

Highbridge International LLC                                   $9,250,000                            229,414

ITG, Inc.                                                        $200,000                              4,960

Jefferies & Company                                              $200,000                              4,960

J.P. Morgan Securities, Inc.                                   $4,375,000                            108,506

KBC Financial Products                                         $5,000,000                            124,007

Key Asset Management Inc.                                        $200,000                              4,960

Lazard Freres & Cie Paris (5)                                  $1,500,000                             37,202

LDG Limited                                                      $200,000                              4,960

McMahan Securities Co., L.P.                                   $1,600,000                             39,682

Merrill Lynch, Pierce, Fenner and
Smith Inc. (4)                                                 $4,105,000                            101,810

MichaelAngelo, L.P.                                            $1,750,000                             43,402

Morgan Stanley & Co.                                          $10,000,000                            248,015

</TABLE>

                                      -2-

<PAGE>



<TABLE>
<CAPTION>
                                                                                               NUMBER OF SHARES OF
                                                                                              COMMON STOCK ISSUABLE
                                                       PRINCIPAL AMOUNT OF NOTES              UPON CONVERSION OF THE
                                                           BENEFICIALLY OWNED                    NOTES THAT MAY BE
  NAME OF SECURITY HOLDER                                    AND OFFERED(1)                         OFFERED(2)
  -----------------------                              -------------------------              ----------------------
<S>                                                    <C>                                    <C>

New York Life Insurance and
Annuity Corporation                                            $1,100,000                             27,281

New York Life Insurance Company                                $6,500,000                            161,210

Onex Industrial Partners                                       $5,000,000                            124,007

Pebble Capital Inc.                                            $3,000,000                             74,404

Quattro Fund Ltd                                                 $500,000                             12,400

R2 Investments, LDC                                           $27,600,000                            684,523

Raphael II, Ltd.                                               $1,000,000                             24,801

RCG Multi-Strategy Account, L.P.                                 $750,000                             18,601

Robertson Stephens (3)                                        $12,500,000                            310,019

Salomon Brothers Asset Management, Inc.                       $36,930,000                            915,922

SG Cowen Securities (3)                                       $10,000,000                            248,015

Silver Creek Limited Partnership                               $2,000,000                             49,603

Susquehanna Capital Group                                      $2,955,000                             73,288

TQA Master Fund, LTD                                           $2,700,000                             66,964

TQA Master Plus Fund, LTD                                      $1,000,000                             24,801

Tribeca Investments LLC                                        $8,500,000                            210,813

UBS Warburg LLC                                                $5,500,000                            136,408

White River Securities LLC                                       $500,000                             12,400

Zurich HFR Master Fund                                           $100,000                              2,480

</TABLE>


(1)    The number of securities beneficially owned is determined under the rules
       of the SEC and the information is not necessarily indicative of
       beneficial ownership for any other purpose. Under those rules, beneficial
       ownership includes any securities as to which the individual has sole or
       shared voting power or investment power and also any securities which the
       individual has the right to acquire within 60 days through the exercise
       of any stock option or other right. The inclusion in the table of
       securities, however, does not constitute an admission that the selling
       holders are direct or indirect beneficial owners of those securities. The
       selling holders have sole voting power and investment power with respect
       to all securities or capital stock listed as owned by the selling
       holders.

                                      -3-

<PAGE>

(2)    Adjusted to reflect the two-for-one stock split of our common stock
       effected by way of a stock dividend distributed on August 31, 2000, and
       the resulting adjustment in the conversion price of the notes from $80.64
       to $40.32 per share.

(3)    As of September 11, 2000, Alta Partners Holdings, Inc. beneficially
       owned 117,700 shares of our Common Stock. These shares are not part
       of this offering.

(4)    Acted as one of the initial purchasers of the notes.

(5)    As of May 22, 2000, Lazard Freres & Cie Paris owned 7,360 shares of our
       common  stock.  These shares are not part of this offering.


This Prospectus Supplement No. 4 should be read in conjunction with the
Prospectus dated August 1, 2000


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