CARDIAC SCIENCE INC
S-3, 2000-10-17
ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS
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<PAGE>

As filed with the Securities and Exchange Commission
on October 17, 2000                                   Registration No. 333-94475
--------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                          -----------------------------

                                    FORM S-3

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                              CARDIAC SCIENCE, INC.
                              ---------------------
             (Exact Name of Registrant as Specified in Its Charter)

         DELAWARE                      3845                     33-0465681
         --------                      ----                     ----------
(State or Other Jurisdiction of (Primary Standard Industrial (I.R.S. Employer
Incorporation or Organization)  Classification Code Number)  Identification No.)

                                 --------------
                              16931 Millikan Avenue
                            Irvine, California 92606
                                 (949) 587-0357
                                 --------------

    (Address, Including Zip Code, and Telephone Number, Including Area Code,
                  of Registrant's Principal Executive Offices)

                                 --------------
                           RAYMOND W. COHEN, PRESIDENT
                              Cardiac Science, Inc.
                              16931 Millikan Avenue
                            Irvine, California 92606
                                 (949) 587-0357
                                 --------------
  (Name, Address Including Zip Code, and Telephone Number, Including Area Code,
                             of Agent For Service)

                                 --------------
       Copies of all communications, including all communications sent to
                   the agent for service, should be sent to:
                            LEONARD J. BRESLOW, ESQ.
                              Breslow & Walker, LLP
                        100 Jericho Quadrangle, Suite 230
                             Jericho, New York 11753
                   Tel: (516) 822-6505    Fax: (516) 822-6544

                                 --------------
Approximate date of commencement of proposed sale to the public: From time to
time after this Registration Statement becomes effective.

If any of the securities being registered on this form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act, check
the following box /X/

If this form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the Securities Act registration statement number of the earlier effective
registration statement for the same offering / /

If this form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering / /

If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box / /

The registrant hereby amends this Registration Statement on such date or dates
as may be necessary to delay its effective date until the registrant shall file
a further amendment which specifically states that this Registration Statement
shall thereafter become effective in accordance with Section 8(a) of the
Securities Act of 1933 or until the Registration Statement shall become
effective on such date as the Commission, acting pursuant to Section 8(a), may
determine.

Pursuant to Rule 429 of the Securities Act, the prospectus included in this
Registration Statement is a combined prospectus relating to the sale of the
securities registered hereby and by Registration Statement No. 333-94425. This
Registration Statement, which is a new registration statement, also constitutes
Post-Effective Amendment No. 2 to Registration Statement No. 333-94425, and such
Post-Effective Amendment No. 2 shall become effective concurrently with the
effectiveness of this Registration Statement in accordance with Section 8(c) of
the Securities Act.


<PAGE>
--------------------------------------------------------------------------------
                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
                                                                     Proposed
                                                                      Maximum          Proposed
                                                      Amount          Offering          Maximum         Amount of
 Title of Each Class of Securities                     to be          Price Per         Aggregate      Registration
        to be Registered                             Registered      Security(2)     Offering Price         Fee
-------------------------------------------------------------------------------------------------------------------

<S>                                                  <C>               <C>            <C>                 <C>
Common Stock, par value $0.001 per share(1)          19,978,494        $7.9375        $158,579,296        $41,865
-------------------------------------------------------------------------------------------------------------------
</TABLE>

         (1)      Represents shares of common stock which may be sold by selling
                  stockholders. An additional 8,791,630 shares of common stock
                  which may be sold by selling stockholders have been registered
                  under an earlier Registration Statement on Form S-1 (File No.
                  333-94425) which was initially declared effective by the
                  Securities and Exchange Commission on February 7, 2000. A
                  filing fee of $10,886 was paid at the time such earlier
                  registration statement was originally filed.

         (2)      Estimated solely for the purpose of calculating the amount of
                  the registration fee pursuant to Rule 457(c) under the
                  Securities Act of 1933, as amended. Represents the average of
                  the high and the low prices of the Common Stock as quoted on
                  the NASDAQ National Market on October 13, 2000.

                  Pursuant to Rule 416 of the Securities Act of 1933, this
         registration statement also relates to such additional indeterminate
         number of shares of Common Stock as may become issuable pursuant to the
         anti-dilution provisions of the warrants held by certain of the selling
         stockholders.

                  The registrant hereby amends this Registration Statement on
         such date or dates as may be necessary to delay its effective date
         until the registrant shall file a further amendment which specifically
         states that this Registration Statement shall thereafter become
         effective in accordance with Section 8(a) of the Securities Act of 1933
         or until the Registration Statement shall become effective on such date
         as the Commission, acting pursuant to Section 8(a), may determine.


                                       2
<PAGE>

                              CARDIAC SCIENCE, INC.

                                19,978,494 Shares

                                  Common Stock

                                   -----------

         This prospectus relates to 19,978,494 shares of common stock which may
be offered and sold, from time to time, by the selling stockholders named in
this prospectus. We will not receive any proceeds from the sale of the shares by
the selling stockholders.

         Our common stock currently is quoted on the Nasdaq National Market
under the symbol "DFIB." On October 13, 2000, the last reported sale price of
our common stock was $7.97 per share.

         See "Risk Factors" commencing on page 7 to read about the risks you
should consider before buying shares of our common stock.

         Neither the Securities and Exchange Commission nor any state securities
commission has approved or disapproved or these securities or passed upon the
accuracy or adequacy of this prospectus. Any representation to the contrary is a
criminal offense.

         We will bear all costs and expenses of the registration of the shares
under the Securities Act and certain state securities laws, other than fees of
counsel for the selling stockholders and any discounts or commissions payable
with respect to sales of the shares.



                The date of this prospectus is October ___, 2000


                                       3
<PAGE>


                                TABLE OF CONTENTS

                                                                            Page

The Company ...............................................................    4
Forward Looking Statements ................................................    6
Risk Factors ..............................................................    7
Selling Stockholders and Plan of Distribution .............................   16
Use of Proceeds ...........................................................   22
Legal Matters .............................................................   23
Experts ...................................................................   23
Where You Can Find More Information .......................................   23

                                   -----------

         You should rely only on the information contained in this prospectus.
We have not, and the selling stockholders have not, authorized any person to
provide you with different information. If anyone provides you with different or
inconsistent information, you should not rely on it.

         We are not, and the selling stockholders are not, making an offer to
sell these securities in any jurisdiction where the offer or sale is not
permitted.

         You should assume that the information appearing the this prospectus is
accurate as of the date on the front cover of this prospectus only. Our
business, financial condition, results of operations and prospects may have
changed since that date.

                                   THE COMPANY

         We have developed proprietary tachyarrhythmia detection and
discrimination software, RHYTHMx ECD(TM), to be incorporated into devices that
are attached prophylactically to patients determined to be at risk of sudden
cardiac arrest. RHYTHMx ECD enables these devices, such as external
defibrillator monitors and patient monitoring systems, to provide patients
suffering sudden cardiac arrest with potentially lifesaving defibrillation
therapy in as little as 10 seconds without human intervention. We have licensed
RHYTHMx ECD"to one third party, and intend to license it to others. We also have
designed, are developing, and intend to market non-invasive automatic external
cardiac defibrillation or "AECD(R)" devices that use RHYTHMx ECD as well as our
other proprietary technology. We believe our proprietary technology will help to
create a new standard of care by significantly increasing the rate at which
patients survive sudden cardiac arrests.


                                       4
<PAGE>

         Our first device, the Powerheart, is the only FDA cleared non-invasive
external cardioverter defibrillator device that provides fully automatic
detection and treatment of ventricular tachyarrhythmias for in-hospital
patients. In December 1998, we entered into a five-year exclusive distribution
and licensing agreement with Medtronic Physio-Control, a subsidiary of
Medtronic, Inc. Medtronic Physio-Control will market the Powerheart in the U.S.,
Canada, and selected European countries, and also has been licensed to integrate
RHYTHMx ECD into Medtronic's LIFEPAK(R) line of in-hospital external
defibrillators. We also have signed distribution agreements with other
distributors which, together with Medtronic Physio-Control, give us
representation in a total of 41 countries.

         In addition to the Powerheart, we are developing two other products
based on our proprietary technology:

         o        a fully automatic defibrillator module that is designed to be
                  embedded and integrated into existing, third party patient
                  monitoring systems which typically are located in most acute
                  care areas within hospitals; and

         o        a small, wearable, "cell phone sized" fully automatic
                  defibrillator that is designed to be worn by patients who are
                  ambulatory in either a hospital or home environment.

         Our strategy is to rapidly build a large installed base of products
using our proprietary technology through strategic alliances with established
industry leaders and by marketing through country-specific, independent
international distributors. We hope to generate revenue from licensing RHYTHMx
ECD, from selling devices that use our proprietary technology, and from
recurring sales of our single-use, disposable defibrillator pads. Both the
Powerheart and the automatic defibrillator module utilize these disposable
defibrillator pads which, for sanitary, safety, and performance reasons, must be
changed once every 24 hours. Our disposable defibrillator pads feature our
proprietary "smart chip" technology, designed to assure that only our pads will
be used with defibrillator and monitoring devices utilizing our proprietary
technology.

         We were incorporated in the State of Delaware in May 1991. Our
principal executive offices are located at 16931 Millikan Avenue, Irvine,
California 92606. Our phone number is 949-587-0357. Our website address is
cardiacscience.com. The information on our website is not a part of this
prospectus.


                                       5
<PAGE>


                           FORWARD LOOKING STATEMENTS

         This prospectus contains certain forward-looking statements within the
meaning of Section 27A of the Securities Act and Section 21E of the Securities
Exchange Act, including statements regarding:

         o        products under development;

         o        technological and competitive advantages;

         o        timetable for commercial introduction of our products;

         o        our ability to improve patient care, increase survival rates,
                  decrease recovery time, lessen patient debilitation, and
                  reduce patient care costs;

         o        markets, demand for our services, purchase orders and
                  commitments;

         o        strategic alliances; and

         o        the competitive and regulatory environment.

         These forward-looking statements are based on current expectations that
involve numerous risks and uncertainties. Assumptions relating to the foregoing
involve judgments with respect to, among other things, future economic,
competitive, and market conditions and future business decisions, all of which
are difficult or impossible to predict accurately and many of which are beyond
our control. Although we believe that our assumptions underlying the
forward-looking statements are reasonable, any of the assumptions could prove
inaccurate and, therefore, we cannot assure you that the results discussed or
implied in such forward-looking statements will prove to be accurate. In light
of the significant uncertainties inherent in such forward-looking statements,
the inclusion of such statements should not be regarded as a representation by
us or any other person that our objectives and plans will be achieved. Words
such as "believes," "anticipates," "expects," "intends," "may," and similar
expressions are intended to identify forward-looking statements, but are not the
exclusive means of identifying such statements. We undertake no obligation to
revise any of these forward-looking statements.


                                       6
<PAGE>


                                  RISK FACTORS

         An investment in our common stock involves a high degree of risk. You
should carefully review and consider the risks and uncertainties described below
as well as the other information set forth in this prospectus before investing
in our common stock. If any of the following risks actually occur, our business,
financial condition, or operating results could be materially adversely
affected. In such case, the trading price of our common stock could decline and
you may lose all or part of your investment.

We have a limited operating history and a history of losses, we expect to incur
losses in the future, and our auditors have expressed doubt as to our ability to
continue as a going concern

         We were formed in 1991 and have been engaged primarily in
organizational activities, research and development, pre-clinical testing, human
clinical trials, and capital raising activities. In February 1994, we
substantially curtailed our operations due to lack of funds. In May 1994, we
temporarily ceased all activities except those related to obtaining financing.
We resumed operations upon the completion of a private placement financing in
September 1994.

         We incurred net losses of $5,516,151 for the six months ended June 30,
2000, $7,719,759 for the year ended December 31, 1999, and $4,438,734 for the
year ended December 31, 1998. As of June 30, 2000, we had an accumulated deficit
of $24,454,296, which has since increased. The development and commercialization
of our products will require substantial expenditures for research and
development, regulatory clearances, and the establishment of manufacturing,
marketing, and sales capabilities. As a result, we anticipate that we will
continue to incur losses for the foreseeable future.

         We received a report on our consolidated financial statements from our
independent accountants for the year ended December 31, 1999 that includes an
explanatory paragraph expressing substantial doubt as to our ability to continue
as a going concern without, among other things, obtaining additional financing
adequate to support our research and development activities, or achieving a
level of revenues adequate to support our cost structure.

Our business is subject to factors outside our control

         Our business may be affected by a variety of factors, many of which are
outside our control. Factors that may affect our business include:

         o        the success of our product development efforts;

         o        the success of our marketing campaign;

         o        competition;

         o        our ability to attract qualified personnel;


                                       7
<PAGE>

         o        the amount and timing of operating costs and capital
                  expenditures necessary to establish our business, operations,
                  and infrastructure;

         o        governmental regulation; and

         o        general economic conditions as well as economic conditions
                  specific to the medical industry.

Our products, some of which are still under development, may not be readily
accepted by the market

         Although defibrillation techniques are well known within the medical
community worldwide and are considered to be accepted and effective medical
therapy, we can not assure you that the market will recognize the benefits or
the potential applications of our products. Even if we are able to successfully
demonstrate to physicians and potential customers the benefits, safety,
efficacy, and cost-effectiveness of our products, we cannot assure you that
there will be sufficient market acceptance and demand of our products to allow
us to operate profitably.

We have limited manufacturing experience

         We have limited manufacturing experience, and no experience in
manufacturing products in the volumes that will be necessary for us to achieve
significant commercial sales. We may encounter difficulties in establishing our
production capabilities, including problems involving quality control and
assurance, and shortages of qualified personnel. In addition, our manufacturing
facilities will be subject to applicable FDA regulations, international quality
standards, and other regulatory requirements. Failure by us to maintain our
facilities in accordance with FDA regulations, international quality standards,
or other regulatory requirements may result in delays or termination of
production, which could have a material adverse effect on our business,
financial condition, and results of operations.

We must maintain and establish strategic alliances and other third party
relationships to implement our business strategy

         Our strategy for manufacturing, marketing, and distributing our
products is dependent upon forming strategic alliances and relationships with
joint venture partners, contract manufacturers, or other third parties, and upon
the subsequent success of these parties in performing their responsibilities. We
cannot assure you that our existing arrangements or those which we may establish
in the future will be successful. There would be a material adverse effect on us
if

         o        any of our existing arrangements are cancelled or are
                  unsuccessful, and we are unable to secure new alliances in
                  their place; or

         o        we are unable to secure additional strategic alliances.


                                       8
<PAGE>

We must comply with governmental regulations and industry standards

         We are subject to significant regulations by authorities in the United
States and foreign jurisdictions regarding the clearance of our products and the
subsequent manufacture, marketing, and distribution of our products once
approved. The design, efficacy, and safety of our products are subject to
extensive and rigorous testing before receiving marketing clearance from the
FDA. The FDA also regulates the registration, listing, labeling, manufacturing,
packaging, marketing, promotion, distribution, record keeping and reporting for
medical devices. The process of obtaining FDA clearances is lengthy and
expensive, and we cannot assure you that we will be able to obtain the necessary
clearances for marketing our products on a timely basis, if at all. Failure to
receive or delays in receiving regulatory clearances would limit our ability to
commercialize our products, which would have a material adverse effect on our
business, financial condition, and results of operations. Even if such
clearances are granted by the FDA, our products will be subject to continual
review. Later discovery of previously undetected problems or failure to comply
with regulatory standards may result in restriction of the product's labeling, a
costly and time-consuming product recall, withdrawal of clearance, or other
regulatory or enforcement action. Moreover, future governmental statutes,
regulations, or policies, or changes in existing statutes, regulations, or
policies, may have an adverse effect on the development, production, or
distribution of our products.

         Any regulatory clearance, if granted, may include significant
limitations on the uses for which our products may be marketed. FDA enforcement
policy strictly prohibits the marketing of cleared medical devices for
unapproved uses. In addition, the manufacturing processes used to produce our
products will be required to comply with the Good Manufacturing Practices or
"GMP" regulations of the FDA. These regulations cover design, testing,
production, control, documentation, and other requirements. Enforcement of GMP
regulations has increased significantly in the last several years, and the FDA
has publicly stated that compliance will be more strictly scrutinized. Our
facilities and manufacturing processes and those of certain of our third party
contract manufacturers and suppliers will be subject to periodic inspection by
the FDA and other agencies. Failure to comply with applicable regulatory
requirements could result in, among other things,

         o        warning letters,

         o        fines,

         o        injunctions,

         o        civil penalties,

         o        recalls or seizures of products,

         o        total or partial suspension of production,

         o        refusal of the government to grant pre-market clearance or
                  pre-market approval for devices,


                                       9
<PAGE>


         o        withdrawal of clearances, or

         o        criminal prosecution.

         To market our products in certain foreign jurisdictions, we (or our
distributors and agents) must obtain required regulatory clearances and
approvals and otherwise comply with extensive regulations regarding safety and
quality. Compliance with these regulations and the time required for regulatory
reviews vary from country to country. We cannot assure you that we will obtain
regulatory clearances and approvals in foreign countries, and we may be required
to incur significant costs in applying for, obtaining, or maintaining foreign
regulatory clearances and approvals.

We face intense competition

         The domestic and international markets for external defibrillators are
highly competitive. Our products will compete with a variety of existing
external defibrillators that are presently in widespread use, including devices
which are designed to automatically perform the diagnosis of the patient but
with which therapy is manually initiated by a trained medical technician. The
external defibrillation market is dominated by

         o        Medtronic Physio-Control, a wholly-owned subsidiary of
                  Medtronic, Inc.;

         o        Agilent (a spin-off from Hewlett Packard Corporation) and its
                  subsidiary, HeartStream, Inc.; and

         o        Zoll Medical, Inc.

         Other competitors in this market segment include Marquette Electronics,
Inc., SurVivaLink Corporation, and Laerdal Corporation. Many of the
manufacturers of competing external devices

         o        are well established in the medical device field,

         o        have substantially greater experience than us in research and
                  development, obtaining regulatory clearances, manufacturing,
                  and sales and marketing, and

         o        have significantly greater financial, research, manufacturing,
                  and marketing resources than us.

         Other companies can develop invasive or non-invasive products capable
of delivering comparable or greater therapeutic benefits than our products or
which offer greater safety or cost effectiveness than our products. Furthermore,
future technologies or therapies developed by others may render our products
obsolete or uneconomical, and we may not be successful in marketing our products
against such competitors.


                                       10
<PAGE>


If we sell our products internationally, we will be exposed to numerous risk
associate with international operations

         We intend to market our products in international markets.
International operations entail various risks, including

         o        political instability;

         o        economic instability and recessions;

         o        exposure to currency fluctuations;

         o        difficulties of administering foreign operations generally;

         o        reduced protection for intellectual property rights;

         o        potentially adverse tax consequences; and

         o        obligations to comply with a wide variety of foreign laws and
                  other regulatory requirements.

We have limited sales and marketing capabilities

         We have limited sales and marketing resources. Although our executive
management team has extensive marketing and sales experience in the cardiology
field, we cannot assure you that our marketing and sales efforts will be
successful. We intend to market our products in the United States and certain
foreign countries via a strategic distribution alliance with Medtronic
Physio-Control, Inc. We intend to market our products in other foreign countries
through a network of international distributors, of which 30 distributors have
already entered into exclusive, country-specific agreements. We cannot assure
you that we will be able to consummate additional strategic distribution
partnerships with other companies for our products, or that distributors will
devote adequate time or resources to selling our products.

Our business is dependent upon our executive officers, and our ability to
attract and retain other key personnel

         Our success is dependent in large part on the continued employment and
performance of our President and Chief Executive Officer, Raymond W. Cohen, as
well as other key management and operating personnel. The loss of any of these
persons could have a material adverse effect on the business. We do not have key
person life insurance on any of our employees.

         Our future success also will depend upon our ability to retain existing
key personnel, and to hire and to retain additional qualified technical,
engineering, scientific, managerial, marketing, and sales personnel. The failure
to recruit such personnel, the loss of such existing personnel, or failure to
otherwise obtain such expertise would have a material adverse effect on our
business and financial condition.


                                       11
<PAGE>


We may face product liability claims

         The testing, manufacturing, marketing and sale of medical devices
subjects us to the risk of liability claims or product recalls. For example, it
is possible that our products will fail to deliver an energy charge when needed
by the patient, or that they will deliver an energy charge when it is not
needed. As a result, we may be subject to liability claims or product recalls
for products to be distributed in the future or products that have already been
distributed. Although we maintain product liability insurance in the countries
in which we intend to conduct business, we cannot assure you that such coverage
is adequate or will continue to be available at affordable rates. Product
liability insurance is expensive and may not be available in the future on
acceptable terms, if at all. A successful product liability claim could inhibit
or prevent commercialization of our products, impose a significant financial
burden on us, or both, and could have a material adverse effect on our business
and financial condition.

Our technology may become obsolete

         The medical equipment and health care industries are characterized by
extensive research and rapid technological change. The development by others of
new or improved products, processes, or technologies may make our products
obsolete or less competitive. Accordingly, we plan to devote continued
resources, to the extent available, to further develop and enhance our existing
products and to develop new products. We cannot assure you that these efforts
will be successful.

We depend on patents and proprietary rights

         Our success will depend, in part, on our ability to obtain and maintain
patent rights to preserve our trade secrets and to operate without infringing on
the proprietary rights of third parties. The validity and breadth of claims
covered in medical technology patents involve complex legal and factual
questions and therefore may be highly uncertain. We cannot assure you that

         o        any additional patents will be issued to us,

         o        the scope of any existing or future patents will exclude
                  competitors or provide us with competitive advantages,

         o        any of our patents will be held valid and enforceable if
                  challenged, or

         o        others will not claim rights in or ownership to the patents
                  and other proprietary rights held by us.

         Furthermore, others may have developed or could develop similar
products or patent rights, may duplicate our products, or design around our
current or future patents. In addition, others may hold or receive patents which


                                       12
<PAGE>

contain claims having a scope that covers products developed by us. We also rely
upon trade secrets to protect our proprietary technology. Others may
independently develop or otherwise acquire substantially equivalent know-how, or
gain access to and disclose our proprietary technology. We cannot assure you
that we can ultimately protect meaningful rights to our proprietary technology.

We may not be able to protect our intellectual property rights

         There has been substantial litigation regarding patent and other
intellectual property rights in the medical device industry. Such litigation, if
it occurs, could result in substantial expense to us and diversion of our
efforts, but may be necessary to

         o        enforce our patents,

         o        protect our trade secrets and know-how,

         o        defend us against claimed infringement of the rights of
                  others, or

         o        determine the enforceability, scope, and validity of the
                  proprietary rights of others.

         An adverse determination in any such litigation could subject us to
significant liability to third parties or require us to seek licenses from third
parties. Although patent and intellectual property disputes in the medical
device industry have often been settled through licensing or similar
arrangements, costs associated with such arrangements may be substantial and
could include ongoing royalties. Moreover, we cannot assure you that necessary
licenses would be available to us on satisfactory terms, if at all. If such
licenses cannot be obtained on acceptable terms, we could be prevented from
marketing our products. Accordingly, an adverse determination in such litigation
could have a material adverse effect on our business and financial condition.

Our stock price may be volatile

         The market prices of many publicly traded companies, including emerging
companies in the health care industry, have been and can be expected to be
highly volatile. The future market price of our common stock could be
significantly impacted by

         o        future sales of our common stock,

         o        announcements of technological innovations for new commercial
                  products by our present or potential competitors,

         o        developments concerning proprietary rights,

         o        adverse results in our field or with clinical tests,

         o        adverse litigation,


                                       13
<PAGE>

         o        unfavorable legislation or regulatory decisions,

         o        public concerns regarding our products,

         o        variations in quarterly operating results,

         o        general trends in the health care industry, and

         o        other factors outside of our control.

We do not anticipate paying dividends

         To date, we have not declared or paid dividends on our common stock. We
presently intend to retain earnings, if any, to finance our operations and do
not expect to pay cash dividends on our common stock in the foreseeable future.
The payment of dividends will depend, among other things, upon our earnings,
assets, general financial condition, and upon other relevant factors.

Our right to issue preferred stock could adversely affect common stockholders

         Our certificate of incorporation authorizes the issuance of preferred
stock with such designations, rights, and preferences as may be determined from
time to time by our Board of Directors, without any further vote or action by
our stockholders. Therefore, our Board of Directors is empowered, without
stockholder approval, to issue a class of stock with dividend, liquidation,
conversion, voting, or other rights, which could adversely affect the voting
power or other rights of the holders of our common stock.

Anti-takeover provisions may discourage takeover attempts

         Provisions of the Delaware General Corporation Law and our charter may
discourage potential acquisition proposals or delay or prevent a change of
control.

Future issuances of our common stock could cause our stock price to decline

         As of October 16, 2000 we have reserved a total of 2,805,000 shares of
our common stock for issuance upon the exercise of options that may be granted
under our Amended 1997 Stock Option/Stock Issuance Plan, and a total of
1,441,101 shares of our common stock for issuance upon the exercise of currently
outstanding warrants to purchase common stock. The holders of these options or
warrants may exercise them at a time when we would otherwise be able to obtain
additional equity capital on terms more favorable to us. The exercise of these
options or warrants and the sale of the common stock obtained upon exercise
would have a dilutive effect on our stockholders, and may have a material
adverse effect on the market price of our common stock. In addition, the
issuance of options pursuant to our Stock Option Plan may adversely affect our
ability to consummate future equity financings.


                                       14
<PAGE>

Shares eligible for future sale may adversely affect our stock price

         A substantial number of our shares are available for future sale. If
these shares are sold in the public market, it may adversely affect prevailing
market prices for our common stock and could impair our ability to raise capital
through future sales of equity securities.


                                       15
<PAGE>


                  SELLING STOCKHOLDERS AND PLAN OF DISTRIBUTION

         The following table sets forth

         o        the names of each of the selling stockholders,

         o        the number of shares of common stock beneficially owned by
                  each selling stockholder prior to the offering,

         o        the number of shares of common stock that may be offered by
                  each of the selling stockholders pursuant to this prospectus,
                  and

         o        the number of shares of common stock beneficially owned by
                  each selling stockholder after completion of the offering,
                  assuming all of the shares covered by this prospectus are
                  sold.

<TABLE>
<CAPTION>
                                                          Number of         Number of
                                     Number of           Securities        Securities
                                     Securities          Offered for          Owned
                                    Beneficially           Selling         Beneficially        Percentage
Name of                             Owned Prior          Stockholder's         After           Owned After
Selling Stockholder                 to Offering            Account           Offering           Offering
-------------------                 -----------            -------           --------           --------
<S>                                  <C>                 <C>                   <C>                   <C>
Thomas Girschweiler                    763,320(1)          698,225(1)           65,095               +
Eduard P. Kauffmann                     62,500              62,500                  --               0
Michele Martucci                        72,400              72,400                  --               0
Erhard Lee                              72,400              72,400                  --               0
Larry Koppes                            11,310              11,310                  --               0
Richard Potter                          10,000              10,000                  --               0
Jeff Turcotte                           11,309              11,309                  --               0
Walter Villiger                      1,383,750(2)        1,383,750(2)               --               0
AACPAC Holdings Limited                292,100             292,100                  --               0
Medtronic Physio-Control Corp.         450,000(3)          450,000(3)               --               0
SMS Group, AG                          125,000             125,000                  --               0
Wilfried Girschweiler                   50,000              50,000                  --               0
Ernst Muller-Mohl                    2,983,750(4)        2,743,750(4)          240,000               +
Swiss Bank Corporation                  20,000(5)           20,000(5)               --               0
Rush & Company                         150,000             150,000                  --               0
Stuart Karten                           25,000              25,000                  --               0
Dongping Lin (a)                        10,000              10,000                  --               0
Don Hill (d)                           115,289(6)          104,966(6)           10,323               +
BWM Investments (c)                    264,688(7)          262,500(7)            2,188               +
Fran Daniels                            87,500(8)           87,500(8)           39,375               +
Howard Cooper (e)                       79,965(9)           79,965(9)               --               0
Paul Quadros (b)                        33,738(21)          17,500(21)          16,238               +
S.K. Bales                              14,250              14,250                  --               0
Global Asset Strategies                 41,100              30,000              11,100               +
Trafina Privatbank, A.G                 20,000(10)          20,000(10)              --               0
Thomas P. Plotts                         5,000(11)           5,000(11)              --               0
</TABLE>


                                       16
<PAGE>


<TABLE>
<CAPTION>
                                                          Number of         Number of
                                     Number of           Securities        Securities
                                     Securities          Offered for          Owned
                                    Beneficially           Selling         Beneficially        Percentage
Name of                             Owned Prior          Stockholder's         After           Owned After
Selling Stockholder                 to Offering            Account           Offering           Offering
-------------------                 -----------            -------           --------           --------
<S>                                  <C>                 <C>                   <C>                 <C>
Clariden Bank, Zurich                   37,500              37,500                  --               0
Cantrade AG                             28,750(12)          28,750(12)              --               0
EB Research Institute AG                14,375              14,375                  --               0
Gandola Stiftung                       287,500(13)         287,500(13)              --               0
HD Fuchs                               138,000(14)         138,000(14)              --               0
Renee Heinen                           143,750(15)         143,750(15)              --               0
Actieninvest AG                        655,345(16)         655,345(16)              --               0
Roderick de Greef                      245,211(17)(23)     113,450(17)              --               0
A & A ActienBank                       575,000(18)         575,000(18)              --               0
Suan Investments                        52,800              30,000              22,800               +
Zevex Incorporated                     135,000             135,000                  --               0
James W. Giddens, Trustee               28,438              28,438                  --               0
Michael Rapaport                        26,250              26,250                  --               0
Leo Fox                                  8,750               8,750                  --               0
John Kinder                             17,500              17,500                  --               0
William J. Hunt, As Trustee of the
Estate of Roman Okin                     6,562               6,562                  --               0
Ike R. Dweck                            87,500(19)          87,500(19)              --               0
Lava Investments Limited               677,747(20)         310,127(20)         367,620             1.5%
Juliber Pty. Ltd.                       33,334              33,334                  --               0
Laliber Pty. Ltd.                       33,333              33,333                  --               0
Niliber Pty. Ltd.                       33,333              33,333                  --               0
Namberry Way Pty. Ltd.                  78,000              78,000                  --               0
NAS House Trust                         60,000              60,000                  --               0
Hollywell Investments Pty. Ltd.         35,000              35,000                  --               0
JNH Australia Pty. Ltd.                  4,000               4,000                  --               0
Thorney Pty. Ltd.                       85,000              85,000                  --               0
Thistle Custodians Pty. Ltd.            85,000              85,000                  --               0
RJ Custodians Pty. Ltd.                 80,000              80,000                  --               0
Jagen Pty. Ltd.                        100,000             100,000                  --               0
Kafig Pty. Ltd.                        222,222             222,222                  --               0
Woodsdale Investments Pty. Ltd.         13,000              13,000                  --               0
Peter Spira                             10,000              10,000                  --               0
Michael Duligal                         10,000              10,000                  --               0
Haralambis Solicitors Nominees No.
3 Pty Ltd.                             165,000             165,000                  --               0
DBR Corporation Pty. Ltd.               22,222              22,222                  --               0
Renspeck Pty. Ltd.                      45,468              45,468                  --               0
Vanborough Pty. Ltd.                    39,000              39,000                  --               0
James Fantaci                           33,333              33,333                  --               0
James V Babcock                         33,333              33,333                  --               0
Daniel J. Brickman                      33,333              33,333                  --               0
Clariden Biotechnology Fund            865,000             865,000                  --               0
Theodore JA Lachowicz and Cheryl
L. Lachowicz 1998 Trust                 33,333              33,333                  --               0
</TABLE>


                                       17
<PAGE>


<TABLE>
<CAPTION>
                                                          Number of         Number of
                                     Number of           Securities        Securities
                                     Securities          Offered for          Owned
                                    Beneficially           Selling         Beneficially        Percentage
Name of                             Owned Prior          Stockholder's         After           Owned After
Selling Stockholder                 to Offering            Account           Offering           Offering
-------------------                 -----------            -------           --------           --------
<S>                                  <C>                 <C>                   <C>                 <C>
Gemm Holdings Pty. Ltd.                 32,550              32,550                  --               0
Fairfax & Roberts Limited               32,550              32,550                  --               0
Cardy & Company Pty. Ltd.               32,550              32,550                  --               0
Tissell Pty. Ltd.                       22,800              22,800                  --               0
Tissell Pty. Ltd. Superannuation
  Benefit Fund                           3,250               3,250                  --               0
Dylide Pty. Ltd.                        19,500              19,500                  --               0
DBM Investments Pty. Ltd.               13,000              13,000                  --               0
Valamoon Pty. Ltd.                      13,000              13,000                  --               0
Andrew Tyndale                          13,000              13,000                  --               0
Sigma Tau Finance SA                   222,000             222,000                  --               0
Karl Heinz ILLenseer                   222,000             222,000                  --               0
Clariden Biotechnology Fund            200,000             200,000                  --               0
Hannes Honegger                         15,000              15,000                  --               0
Beda Kraehenmann                        15,000              15,000                  --               0
Jacob Goldfield                        166,666             166,666                  --               0
Jacob Goldfield Foundation              55,555              55,555                  --               0
Domain Partners IV, LP(f)            1,085,109           1,085,109                  --               0
DP IV Associates, LP(f)                 26,002              26,002                  --               0
HFC Cadent, LP                       2,419,033           2,419,033                  --               0
Fenwick Overseas Limited                44,444              44,444                  --               0
Darma Ltd                               55,555              55,555                  --               0
Prabodh Mathur(a)                       39,125(22)          33,670(22)           5,455               +
Ron Agel                                17,920              17,920                  --               0
Henri Blair                              3,343               3,343                  --               0
Frank Bonsall                            9,176               9,176                  --               0
Gustav Christensen                      14,457              14,457                  --               0
Stephen Chubb                           19,603              19,603                  --               0
Coral Partners IV,L.P                  594,804             594,804                  --               0
Domain Partners III, L.P.(f)           797,247             797,247                  --               0
DP III Associates, L.P.(f)              21,264              21,264                  --               0
3i Bioscience Investment Trust PL      285,603             285,603                  --               0
Peter Feinstein                          1,360               1,360                  --               0
Robert Flynn                            17,486              17,486                  --               0
Edward Gibbons                          25,121              25,121                  --               0
Howard Green, Jr                        19,633              19,633                  --               0
Frederick Grein, Jr                      5,676               5,676                  --               0
Harbus Investors, Inc.                   3,577               3,577                  --               0
John Kao                                 3,265               3,265                  --               0
Lawrence Kinet                           4,572               4,572                  --               0
Thomas Maniatis                         14,630              14,630                  --               0
Gerard Moufflet                         37,133              37,133                  --               0
Desmond O'Connell                       25,051              25,051                  --               0
James O'Leary                            2,796               2,796                  --               0
Guy Reed                                 1,700               1,700                  --               0
Mitchel Sayare                          12,265              12,265                  --               0
Stephen Schaubert                       22,852              22,852                  --               0
Gabrel Schmergel                        56,200              56,200                  --               0
Mark Skaletsky                           1,998               1,998                  --               0
Henri Termeer                           24,290              24,290                  --               0
George Whitesides                       19,045              19,045                  --               0
Peter Wirth                             25,388              25,388                  --               0
Robert Carpenter(b)                    150,862             150,862                  --               0
David Castaldi                          63,152              63,152                  --               0
Randall Fincke                           5,441               5,441                  --               0
Charles Khuen                            7,193               7,193                  --               0
Peter McNerney                          10,065              10,065                  --               0
William Chisholm                         2,155               2,155                  --               0
John Vozella                            10,193              10,193                  --               0
Delash Holdings Pty. Ltd.                5,000               5,000                  --               0
De Greef & Company                     131,761             131,761                  --               0
Equity 4 Life                        1,149,999           1,149,999                  --               0
Cambriatech Holdings SA                  7,518               7,518                  --               0
</TABLE>


                                       18
<PAGE>

+        Less than 1%

(a)      Executive officer

(b)      Director

(c)      BWM Investments is an affiliate of Breslow & Walker, LLP, legal counsel
         to us

(d)      Former Director

(e)      Former Officer and Director

(f)      Domain Partners III, L.P. and DP III Associates, L.P. have the same
         general partner--One Palmer Square Associates III, L.P. ("OPSA III").
         Domain Partners IV, L.P. and DP IV Associates, L.P. have the same
         general partner--One Palmer Square Associates IV, LLC ("OPSA IV").
         Several of the general partners of OPSA III, including Brian Dovey (a
         director of Cardiac Science), are also managing members of OPSA IV.
         Domain Partners III, DP III Associates, Domain Partners IV, and DP IV
         Associates are considered part of the same control group.

(1)      Includes 90,825 shares of common stock underlying currently exercisable
         warrants.

(2)      Includes 33,750 shares of common stock underlying currently exercisable
         warrants.

(3)      Includes 200,000 shares of common stock underlying currently
         exercisable warrants.

(4)      Includes 56,250 shares of common stock underlying currently exercisable
         warrants.

(5)      Consists of 20,000 shares of common stock underlying current
         exercisable warrants.

(6)      Includes 104,966 shares of common stock underlying currently
         exercisable warrants.

(7)      Includes 262,500 shares of common stock underlying currently
         exercisable warrants.

(8)      Consists of 87,500 shares of common stock underlying currently
         exercisable warrants.

(9)      Consists of 79,965 shares of common stock underlying currently
         exercisable warrants.


                                       19
<PAGE>

(10)     Consists of 20,000 shares of common stock underlying currently
         exercisable warrants.

(11)     Consists of 5,000 shares of common stock underlying currently
         exercisable warrants.

(12)     Includes 3,750 shares of common stock underlying currently exercisable
         warrants.

(13)     Includes 37,500 shares of common stock underlying currently exercisable
         warrants.

(14)     Includes 18,000 shares of common stock underlying currently exercisable
         warrants.

(15)     Includes 18,750 shares of common stock underlying currently exercisable
         warrants.

(16)     Includes 81,625 shares of common stock underlying currently exercisable
         warrants.

(17)     Includes 82,050 shares of common stock underlying currently exercisable
         warrants.

(18)     Includes 75,000 shares of common stock underlying currently exercisable
         warrants.

(19)     Consists of 87,500 shares of common stock underlying currently
         exercisable warrants.

(20)     Includes 25,000 shares of common stock underlying currently exercisable
         warrants.

(21)     Includes 17,500 shares of common stock underlying currently exercisable
         warrants.

(22)     Includes 33,670 shares of common stock underlying currently exercisable
         warrants.

(23)     Includes 131,761 shares of common stock owned by De Greef & Company, a
         corporation in which Roderick de Greef is the sole officer and
         director. The sale of the 131,761 shares by De Greef & Company also are
         covered by this prospectus.

         This prospectus covers 19,978,494 shares of common stock that may be
sold by the selling stockholders named herein. From time to time, the selling
stockholders may transfer shares to a donee, pledgee, successor, or other
person, other than for value, and such transfers will not be made pursuant to
this prospectus. Upon being notified by a selling stockholder that such a donee,
pledgee, successor, or other person intends to sell more than 500 shares, we
will file a supplement to this prospectus. To the extent agreed to by us, this
prospectus covers sales by such transferees.

         The selling stockholders will act independently of us in making
decisions with respect to the timing, manner, and size of each sale of shares.
The sale of all or a portion of the shares of common stock offered hereby by the
selling stockholders may be effected from time to time on the NASDAQ National
Market or otherwise, at prevailing market prices at the time of such sales, at
prices related to such prevailing prices, at fixed prices that may be changed or
at negotiated prices. The selling stockholders may effect such transactions by
selling the shares to or through a broker-dealer. The shares may be sold by one
or more of, or a combination of, the following:

         o        block trades in which a broker or dealer so engaged will
                  attempt to sell the shares as agent but may position and
                  resell a portion of the block as principal to facilitate the
                  transaction;

         o        purchases by a broker or dealer as principal and resale by
                  such broker or dealer for its account pursuant to this
                  prospectus;

         o        an exchange distribution in accordance with the rules of such
                  exchange;

         o        ordinary brokerage transactions and transactions in which the
                  broker solicits purchases; and


                                       20
<PAGE>

         o        privately negotiated transactions between sellers and
                  purchasers without a broker or dealer.

         In addition, shares may be transferred in connection with the
settlement of call options, short sales, through the issuance of exchangeable or
convertible securities or similar transactions that may be effected by the
selling stockholders. To the extent required, this prospectus may be amended or
supplemented from time to time to describe a specific plan of distribution.

         In effecting sales, broker-dealers engaged by the selling stockholders
may arrange for other broker-dealers to participate in the resales. Dealers or
brokers may receive compensation in the form of discounts, concessions, or
commissions from the selling stockholders and/or purchasers of shares for whom
they may act as agent (which compensation may be in excess of customary
commissions). The selling stockholders and any brokers or dealers that
participate in the distribution may, under certain circumstances, be deemed to
be "underwriters" within the meaning of the Securities Act, and any commissions
received by such brokers or dealers and any profits realized on the resale of
shares by them may be deemed to be underwriting discounts and commissions under
the Securities Act. We have agreed to indemnify the selling stockholders against
certain liabilities arising under the Securities Act.

         Under applicable rules and regulations under the Exchange Act, any
person engaged in a distribution of the shares may not simultaneously engage in
market-making activities with respect to such shares, except in accordance with
applicable laws. In addition to, and without limiting the foregoing, each
selling stockholder and any other person participating in a distribution will be
subject to the applicable provisions of the Exchange Act and the rules and
regulations thereunder, including, without limitation, Rule 10b-5 and Regulation
M, which provisions may limit the timing of purchases and sales of any of the
shares by a selling stockholder or any other person. All of the foregoing may
affect the marketability of the shares.

         We will make copies of this prospectus available to the selling
stockholders, and we have informed the selling stockholders of the need for
delivery of copies of this prospectus to purchasers at or prior to the time of
any sale of the shares.

         In order to comply with certain state securities laws, if applicable,
the shares will be sold in such jurisdictions only through registered or
licensed brokers or dealers. In addition, in certain states, the shares may not
be sold unless such shares have been registered or qualified for sale in such
state or an exemption from registration or qualification is available and is
complied with.


                                       21
<PAGE>


         We will bear all costs and expenses of the registration of the shares
under the Securities Act and certain state securities laws, other than fees of
counsel for the selling stockholders. The selling stockholders will bear all
commissions, concessions and discounts, if any, related to any sales of the
shares, and may agree to indemnify such brokers or dealers against certain
liabilities, including liabilities arising under the Securities Act.

         The selling stockholders are not restricted as to the number of shares
that may be sold at any one time, and it is possible that a significant number
of shares could be sold at the same time. Sale of the shares by the selling
stockholders may have an adverse effect on the market price of the common stock.





                                       22
<PAGE>


                                 USE OF PROCEEDS

         All net proceeds from the sale of the shares covered by this prospectus
will go to the selling stockholders who sell such shares. We will not receive
any of the proceeds from the sale of the shares by the selling stockholders.

                                  LEGAL MATTERS

         The validity of the securities offered hereby will be passed upon for
us by Breslow & Walker, LLP, New York, New York. BWM Investments, an affiliate
of Breslow & Walker, LLP, owns 2,188 shares of common stock and warrants to
purchase 262,500 of common stock. The re-sale of the shares underlying the
warrants is covered by this prospectus. Howard Breslow, a member of Breslow &
Walker, LLP, owns 875 shares of common stock.

                                     EXPERTS

         The consolidated financial statements incorporated in this prospectus
by reference to the Annual Report on Form 10-K of Cardiac Science, Inc. for the
year ended December 31, 1999 have been so incorporated in reliance on the report
(which contains an explanatory paragraph relating to Cadent Medical
Corporation's ability to continue as a going concern as described in Note 2 to
the consolidated financial statements) of PricewaterhouseCoopers LLP,
independent accountants, given on the authority of said firm as experts in
auditing and accounting.

         The financial statements of Cadent Medical Corporation incorporated by
reference in this prospectus by reference to the Current Report on Form 8-K/A of
Cardiac Science, Inc. dated August 10, 2000 have been so incorporated in
reliance on the report (which contains an explanatory paragraph relating to
Cadent Medical Corporation's ability to continue as a going concern as described
in Note A to the financial statements) of PricewaterhouseCoopers LLP,
independent accountants, given on the authority of said firm as experts in
auditing and accounting.

                       WHERE YOU CAN FIND MORE INFORMATION

         This prospectus is part of a registration statement on Form S-3 that we
filed with the Commission. This prospectus does not contain all of the
information set forth in the registration statement and the exhibits thereto.
Statements contained in this prospectus as to the contents of any contract or
other document referred to are not necessarily complete, and in each instance we
refer you to the copy of such contract or other document filed as an exhibit to
the registration statement, each such statement being qualified in all respects
by the more complete description of the matters involved.


                                       23
<PAGE>


         We are subject to the informational requirements of the Exchange Act
and accordingly, file reports, proxy and information statements and other
information with the Commission. You may read and copy all or any portion of the
registration statement as well as the reports, proxy and information statements
and other information that we have filed with the Commission at the Commission's
public reference room maintained at Room 1024, Judiciary Plaza, 450 Fifth
Street, N.W., Washington, D.C. 20549, and at the regional offices of the
Commission: Seven World Trade Center, 13th floor, New York, New York 10048, and
Northwest Atrium Center, 500 West Madison Street, Suite 1400, Chicago, Illinois
60661. You can request copies of these documents, upon payment of a duplicating
fee, by writing to the Commission. Please call the Commission at 1-800-SEC-0330
for further information on the operation of the public reference rooms. Our
filings with the Commission also are available to you on the Commission's
Internet site (http://www.sec.gov).

         The Commission allows us to "incorporate by reference" certain of our
publicly-filed documents into this prospectus, which means that information
included in these documents is considered part of this prospectus. Information
that we file with the Commission subsequent to the date of this prospectus will
automatically update and superceded this information. We incorporate by
reference the documents listed below and any future filings made with the
Commission under Sections 13(a), 13(c), 14, or 15(d) of the Exchange Act until
the selling stockholders have sold all the shares of common stock described in
this prospectus or until we have de-registered any then remaining unsold shares.

         The following documents filed with the Commission (File No. 0-19567)
are incorporated by reference in this prospectus:

         o        Our Annual Report on Form 10-K for the year ended December 31,
                  1999;

         o        Our Quarterly Reports on Form 10-Q for the quarters ended
                  March 31, 2000 and June 30, 2000;

         o        Our Current Report on Form 8-K dated July 5, 2000, as amended
                  by our Current Report on Form 8-K/A dated August 10, 2000;

         o        Our Definitive Proxy Statement dated April 12, 2000; and

         o        The description of our common stock set forth in our
                  Registration Statement on Form 8-A, including any subsequent
                  amendment or report filed for the purpose of updating that
                  description.

         We will furnish to you, without charge, on your written or oral
request, a copy of any or all of the documents incorporated by reference herein.
You should direct any requests for documents to Secretary, Cardiac Science,
Inc., 16931 Millikan Avenue, Irvine, CA 92606. Our phone number is 949-587-0357.


                                       24
<PAGE>


                                     PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14. Other Expenses of Issuance and Distribution.

         The estimated expenses of the Registrant in connection with the
issuance and distribution of the securities being registered hereby (other than
underwriting discounts and commissions) are as follows:

Registration Fee (Securities and Exchange Commission) ............       $41,865
Accounting Fees and Expenses .....................................       $ 7,500
Legal Fees and Expenses ..........................................       $15,000
Miscellaneous Expenses ...........................................       $ 2,500
                                                                         -------
Total ............................................................       $66,865
                                                                         -------

         The Registrant will bear all costs and expenses of the registration of
the shares under the Securities Act and certain state securities laws, other
than fees of counsel for the selling stockholders and any discounts or
commissions payable with respect to sales of the shares.

Item 15. Indemnification of Directors and Officers.

         Section 145 of the Delaware General Corporation Law provides that a
corporation may indemnify directors and officers as well as other employees and
individuals against expenses (including attorneys' fees), judgments, fines and
amounts paid in settlement actually and reasonably incurred by such person in
connection with any threatened, pending or completed actions, suits or
proceedings in which such person is made a party by reason of such person being
or having been a director, officer, employee or agent to the Registrant. The
Delaware General Corporation Law provides that Section 145 is not exclusive of
other rights to which those seeking indemnification may be entitled under any
bylaw, agreement, vote of stockholders or disinterested directors or otherwise.

         Article VIII of the Registrant's Bylaws provides for indemnification by
the Registrant of its directors, officers and employees to the fullest extent
permitted by the Delaware General Corporation Law and California Law.

         Article VIII of the Registrant's Bylaws also provides for the
prepayment of expenses to persons entitled to indemnification (subject to
certain conditions), and permits the Registrant to purchase and maintain
insurance on behalf of any director, officer, employee, or agent against any
liability asserted against or incurred by them in any such capacity, or arising
out of their status as such, whether or not the Registrant would have the power
or obligation to indemnify them against such liability under the Registrant's
Bylaws.


                                      II-1
<PAGE>


         Section 102(b)(7) of the Delaware General Corporation Law permits a
corporation to provide in its certificate of incorporation that a director of
the corporation shall not be personally liable to the corporation or its
stockholders for monetary damages for breach of fiduciary duty as a director,
except for liability (i) for any breach of the director's duty of loyalty to the
corporation or its stockholders, (ii) for acts or omissions not in good faith or
which involve intentional misconduct or a knowing violation of law, (iii) for
unlawful payments of dividends or unlawful stock repurchase, redemptions or
other distributions, or (iv) for any transaction from which the director derived
an improper personal benefit. Article SIXTH of the Registrant's Certificate of
Incorporation provides for such limitation of liability.

         The general effect of the foregoing provisions is to reduce the
circumstances in which an officer, director, agent, or employee may be required
to bear the economic burdens of the foregoing liabilities and expenses.

Item 16. Exhibits

Exhibit No.       Description
-----------       -----------
5.                Opinion of Counsel

23.1              Consent of PricewaterhouseCoopers LLP regarding Cardiac
                  Science, Inc.

23.2              Consent of PricewaterhouseCoopers LLP regarding Cadent Medical
                  Corporation

23.3              Consent of Breslow & Walker, LLP (contained in opinion of
                  counsel filed as Exhibit 5)

Item 17. Undertakings.

         Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Commission such indemnification is
against public policy as expressed in the Securities Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such
liabilities (other than payment by the Registrant of expenses incurred or paid
by a director, officer or controlling person of the Registrant in the successful
defense of any action, suit or proceeding) is asserted by such director, officer
or controlling person in connection with the securities being registered, the
Registrant will, unless in the opinion of its counsel the matter has been
settled by controlling precedent, submit to a court of appropriate jurisdiction
the question whether such indemnification by it is against public policy as
expressed in the Securities Act and will be governed by final adjudication of
such issue.

         The undersigned Registrant hereby undertakes that it will:

                  (1) For determining any liability under the Securities Act,


                                      II-2
<PAGE>
         treat each post-effective amendment that contains a form of Prospectus
         as a new registration statement for the securities offered in the
         registration statement, and that offering of the securities at that
         time as the initial bona fide offering of those securities.

                  (2) File, during any period in which it offers or sells
         securities, a post-effective amendment to this Registration Statement
         to:

                           (i) Include any prospectus required by Section
                  10(a)(3) of the Securities Act;

                           (ii) Reflect in the prospectus any facts or events
                  arising after the effective date of the registration statement
                  (or the most recent post-effective amendment thereof) which,
                  individually or together, represent a fundamental change in
                  the information set forth in the registration statement.
                  Notwithstanding the foregoing, any increase or decrease in
                  volume of securities offered (if the total dollar value of
                  securities offered would not exceed that which was registered)
                  and any deviation from the low or high end of the estimated
                  maximum offering range may be reflected in the form of
                  prospectus filed with the Commission pursuant to Rule 424(b)
                  if, in the aggregate, the changes in volume and price
                  represent no more than a 20 percent change in the maximum
                  aggregate offering price set forth in the "Calculation of
                  Registration Fee" table in the effective registration
                  statement;

                           (iii) Include any material information with respect
                  to the plan of distribution not previously discussed in the
                  registration statement or any material change to such
                  information in the registration statement;

                  (3) File a post-effective amendment to remove from
         registration any of the securities that remain unsold at the end of the
         offering;

provided, however, that paragraphs (2)(i) and (2)(ii) do not apply if the
information required to be included in a post-effective amendment by those
paragraphs is contained in periodic reports filed by the Registrant pursuant to
Section 13 or Section 15(d) of the Exchange Act that are incorporated by
reference in this registration statement.

                  (4) For purposes of determining any liability under the 1933
         Act, each filing of the Registrant's annual report pursuant to Section
         13(a) or Section 15(d) of the Exchange Act (and, where applicable, each
         filing of an employee benefit plan's annual report pursuant to Section
         15(d) of the Exchange Act) that is incorporated by reference in the
         registration statement shall be deemed to be a new registration
         statement relating to the securities offered therein, and the offering
         of such securities at that time shall be deemed to be the initial bona
         fide offering thereof.


                                      II-3
<PAGE>


                                   SIGNATURES

        In accordance with the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Irvine, State of California, on October 16, 2000.

                           CARDIAC SCIENCE, INC.

                           By: /s/ Raymond W. Cohen
                               --------------------
                               Raymond W. Cohen
                               President, (Principal Executive Officer)

                           By: /s/ Brett L. Scott
                               ------------------
                               Brett L. Scott
                               Chief Financial Officer, (Principal Financial and
                               Accounting Officer)

         In accordance with the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates stated.

         Signature                        Title             Date
         ---------                        -----             ----

/s/ Raymond W. Cohen
--------------------
Raymond W. Cohen                          Director          October 16, 2000

/s/ Paul Quadros
--------------------
Paul Quadros                              Director          October 16, 2000

/s/ Peter Crosby
--------------------
Peter Crosby                              Director          October 16, 2000

/s/ Howard Evers
--------------------
Howard Evers                              Director          October 16, 2000

/s/ Robert Carpenter
--------------------
Robert Carpenter                          Director          October 16, 2000

/s/ Brian Dovey
--------------------
Brian Dovey                               Director          October 16, 2000


                                      II-4
<PAGE>


                              Cardiac Science, Inc.

                                  EXHIBIT INDEX

Exhibit No.       Description
-----------       -----------
5.                Opinion of Counsel
23.1              Consent of PricewaterhouseCoopers LLP regarding Cardiac
                  Science, Inc.
23.2              Consent of PricewaterhouseCoopers LLP regarding Cadent Medical
                  Corporation
23.3              Consent of Breslow & Walker, LLP (contained in opinion of
                  counsel filed as Exhibit 5)




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