BIOTIME INC
10-K405/A, 1997-09-29
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                      ==================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 10-K/A No. 1

             X ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

                     For the fiscal year ended June 30, 1997

                                       OR

            TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934
                        For the transition period from     to

                         Commission file number 1-12830

                                  BioTime, Inc.
             (Exact name of registrant as specified in its charter)

                   California                            94-3127919
         (State or other jurisdiction of             (I.R.S. Employer
         incorporation or organization)             Identification No.)

   935 Pardee Street, Berkeley, California                 94710
   (Address of principal executive offices)              (Zip Code)

        Registrant's telephone number, including area code (510) 845-9535

                 Securities registered pursuant to Section 12(b)
                                  of the Act:

                           Common Shares, no par value
                                (Title of Class)

         Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days. Yes X No

         Indicate by check mark if disclosure of delinquent  filers  pursuant to
Item 405 of Regulation S-K is not contained  herein,  and will not be contained,
to the best of  registrant's  knowledge,  in  definitive  proxy  or  information
statements  incorporated  by  reference  in Part  III of this  Form  10-K or any
amendment to this Form 10-K. [ X ]

The approximate  aggregate market value of voting stock held by nonaffiliates of
the registrant was $105,070,000 as of September 22, 1997.

                                    3,266,193
         (Number of Common Shares outstanding as of September 22, 1997)
                       Documents Incorporated by Reference
                                      None
<PAGE>


Item 14.   Exhibits, Financial Statement Schedules and Reports on Form 8-K

(a-1) Financial Statements.

The following financial statements of BioTime, Inc. are filed in the Form 10-K:

                                                                         Page
                                                                         ----
Independent Auditors' Report                                              35

Balance Sheet at June 30, 1997 and 1996                                   36

Statements of  Operations  for each of the three
years in the period ending June
30, 1997, and for the period from
November 30, 1990 (inception) to June 30, 1997                            37

Statements of Shareholders' Equity for the period
from November 30, 1990 (inception) to June 30, 1997                      38-39

Statements  of Cash Flows for each of the three years
in the period  ending June 30, 1997, and for the period
from November 30, 1990 (inception) to June 30, 1997                      40-41

Notes to Financial Statements                                            42-50




                                       2

<PAGE>



(a-3) Exhibits.

Exhibit
Numbers           Description

 3.1      Articles of Incorporation as Amended.**

 3.3      By-Laws, As Amended.#

 4.1      Specimen of Common Share Certificate.+

10.1      Lease  Agreement  dated July 1, 1994 between the Registrant and Robert
          and Norah  Brower,  relating  to  principal  executive  offices of the
          Registrant.*

10.2      Employment Agreement dated June 1, 1996 between the Company and Paul 
          Segall.++

10.3      Employment Agreement dated June 1, 1996 between the Company and Hal 
          Sternberg.++

10.4      Employment Agreement dated June 1, 1996 between the Company and Harold
          Waitz.++

10.5      Employment Agreement dated June 1, 1996 between the Company and Judith
          Segall.++

10.6      Employment Agreement dated June 1, 1996 between the Company and 
          Victoria Bellport.++

10.7      Intellectual Property Agreement between the Company and Paul Segall.+

10.8      Intellectual Property Agreement between the Company and Hal
          Sternberg.+

10.9      Intellectual Property Agreement between the Company and Harold Waitz.+

10.10     Intellectual Property Agreement between the Company and Judith
          Segall.+

10.11     Intellectual Property Agreement between the Company and Victoria 
          Bellport.+

10.12     Agreement between CMSI and BioTime Officers Releasing Employment 
          Agreements, Selling Shares, and Transferring Non-Exclusive License.+

10.13     Agreement for Trans Time, Inc. to Exchange CMSI Common Stock for 
          BioTime, Inc. Common Shares.+

10.14     1992 Stock Option Plan, as amended.^

10.15     Employment Agreement dated April 1, 1997 between the Company and 
          Ronald S. Barkin.^

10.16     Intellectual Property Agreement between the Company and Ronald S.
          Barkin.^

                                       3

<PAGE>



23.1      Consent of Deloitte & Touche LLP^^


+ Incorporated by reference to  Registration  Statement on Form S-1, File Number
33-44549 filed with the Securities and Exchange Commission on December 18, 1991,
and Amendment No. 1 and  Amendment No. 2 thereto filed with the  Securities  and
Exchange Commission on February 6, 1992 and March 7, 1992, respectively.

# Incorporated by reference to  Registration  Statement on Form S-1, File Number
33-48717 and  Post-Effective  Amendment No. 1 thereto filed with the  Securities
and Exchange Commission on June 22, 1992, and August 27, 1992, respectively.

* Incorporated by reference to the Company's Form 10-K for the fiscal year ended
June 30, 1994.

++ Incorporated  by  reference to the  Company's  Form 10-K for the fiscal year
ended June 30, 1996.

^  Incorporated  by reference to the  Company's  Form 10-Q for the quarter ended
March 31, 1997.

^^ Previously filed September 26, 1997.

** Filed herewith.


                                       4

<PAGE>



                                   SIGNATURES

         Pursuant to the  requirements  of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the Registrant has duly caused this report on Form 10-K to
be signed on its behalf by the  undersigned,  thereunto  duly  authorized on the
26th day of September 1997.

                                  BIOTIME, INC.

                                      /s/: Paul E. Segall
                                  By:______________________________
                                      Paul E. Segall, Ph.D.
                                      President and Chief Executive
                                      Officer (Principal executive officer)

<TABLE>
<CAPTION>

     Signature                            Title                                              Date
- --------------------                ---------------------                               ----------------
<S>                                 <C>                                                 <C>
/s/: Paul E. Segall
- ---------------------
Paul E. Segall, Ph.D.               President, Chief Executive Officer and              September 26, 1997
                                    Director (Principal Executive Officer)

/s/: Ronald S. Barkin
- ---------------------
Ronald S. Barkin                    Executive Vice President and Director               September 26, 1997


/s/: Harold D. Waitz
- ---------------------
Harold D. Waitz, Ph.D.              Vice President and Director                         September 26, 1997


/s/:Hal Sternberg
- ----------------------
Hal Sternberg, Ph.D.                Vice President and Director                         September 26, 1997


/s/:Victoria Bellport
- ----------------------
Victoria Bellport                   Chief Financial Officer and                         September 26, 1997
                                    Director (Principal Financial and
                                    Accounting Officer)

/s/:Judith Segall
- ----------------------
Judith Segall                       Vice President, Corporate Secretary                 September 26, 1997
                                    and Director

- ----------------------
Jeffrey B. Nickel                   Director                                            September 26, 1997
</TABLE>


                                       61





                        AMENDED ARTICLES OF INCORPORATION
                                       OF
                                  BIOTIME, INC.

                   Paul Segall and Judith Segall certify that:

         1. They are the President and the Secretary,  respectively, of BioTime,
Inc., a California Corporation.

         2. The Articles of  Incorporation  of this  corporation  are amended to
read in full as follows:

                  "ONE: The name of this corporation is BioTime, Inc.

                  TWO: The purpose of the corporation is to engage in any lawful
         act or activity  for which a  corporation  may be  organized  under the
         General  Corporation Law of California other than the banking business,
         the trust company business,  or the practice of a profession  permitted
         to be incorporated by the California Corporations Code.

                  THREE:  The  corporation is authorized to issue two classes of
         shares,  which  shall be  designated  "Common  Shares"  and  "Preferred
         Shares".   The  number  of  Common  Shares  which  the  corporation  is
         authorized  to issue is 5,000,000  and the number of  Preferred  Shares
         which  the  corporation  is  authorized  to  issue  is  1,000,000.  The
         Preferred  Shares  may be issued in one or more  series as the board of
         directors  may by  resolution  determine.  The  board of  directors  is
         authorized  to fix the  number  of shares  of any  series of  Preferred
         Shares and to determine or alter the rights,  preferences,  privileges,
         and  restrictions  granted to or  imposed  on the  shares of  Preferred
         Shares as a class,  or upon any wholly unissued series of any Preferred
         Shares. The board of directors may, by resolution, increase or decrease
         (but not below the number of shares of such  series  then  outstanding)
         the number of shares of any series of Preferred  Shares  subsequent  to
         the issue of shares of that series.  Upon the amendment of this article
         to read as herein set forth,  each outstanding share of common stock is
         converted into or reconstituted as 0.1667 Common Share.

                  FOUR:  The liability of the directors of the  corporation  for
         monetary damages shall be eliminated to the fullest extent  permissible
         under  California  law.  The  corporation  is  authorized  to indemnify
         "agents",  as such term is  defined in  Section  317 of the  California
         Corporations  Code, to the fullest extent  permissible under California
         law."

         3. The foregoing  amendment of articles of incorporation  has been duly
approved by the board of directors.

         4. The foregoing  amendment of articles of incorporation  has been duly
approved by the required vote of  shareholders in accordance with Section 902 of
the Corporations Code. The total number of outstanding shares of the corporation
is 5,351,672.  The number of shares voting in favor of the amendment  equaled or
exceeded the vote required. The percentage vote required was more than 50%.

                                        1

<PAGE>


We further  declare  under  penalty  of  perjury  under the laws of the State of
California  that the matters set forth in this amendment are true and correct of
our own knowledge.


Date:  July 15, 1991


                                    /s/: Paul Segall
                                   -----------------------
                                    Paul Segall, President


                                    /s/: Judith Segall
                                    ------------------------
                                    Judith Segall, Secretary


                                        2
<PAGE>



                            CERTIFICATE OF AMENDMENT
                                       OF
                            ARTICLES OF INCORPORATION


         Paul E. Segall and Judith Segall certify that:

     They are the President and  Secretary,  respectively,  of BioTime,  Inc., a
California corporation.

     The  sentence of Article  THREE of the Articles of  Incorporation  that now
reads "The number of Common Shares which the  Corporation is authorized to issue
is  5,000,000  and the  number of  Preferred  Shares  which the  Corporation  is
authorized to issue is 1,000,000" is amended to read as follows:

         "The number of Common  Shares which the  Corporation  is  authorized to
         issue is  25,000,000  and the  number  of  Preferred  Shares  which the
         Corporation is authorized to issue is 1,000,000."

     The foregoing amendment of Articles of Incorporation has been duly approved
by the board of directors.

     The foregoing amendment of Articles of Incorporation has been duly approved
by the  required  vote of  shareholders  in  accordance  with section 902 of the
Corporations  Code.  The  total  number  of  outstanding  Common  Shares  of the
corporation is 3,203,193. There are no Preferred Shares outstanding.  The number
of Common Shares  voting in favor of the amendment  equaled or exceeded the vote
required. The percentage vote required was more than 50%.

     We further  declare under penalty of perjury under the laws of the State of
California  that the matters set forth in this  certificate are true and correct
of our own knowledge.

         Executed at Berkeley, California on June 20, 1997.



         /s/: Paul E. Segall
         ------------------------------------
         Paul E. Segall, President

         /s/: Judith Segall
         ------------------------------------
         Judith Segall, Secretary


                                        3


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