BIOTIME INC
DEF 14A, 2000-06-13
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                            SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
                                (Amendment No. )

Filed by the Registrant [x]
Filed by a Party other than the Registrant [ ]
Check the appropriate box:
[ ] Preliminary  Proxy Statement
[ ] Confidential, for Use of the Commission Only (as permitted by Rule
    14a-6(e)(2))
[x] Definitive Proxy Statement
[ ] Definitive  Additional  Materials
[ ] Soliciting Material pursuant to ss.240.14a-11(c) or ss.240.14a-12

                                  BioTime, Inc.
                 ______________________________________________
                (Name of Registrant as Specified In Its Charter)

      _____________________________________________________________________
     (Name of Person(s) Filing Proxy Statement if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):
[x]  No fee required.
[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.
1)       Title of each class of securities to which transaction applies:

           ____________________________________


      2) Aggregate number of securities to which transaction applies:

           ____________________________________

      3) Per unit price or other underlying value of transaction computed
         pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the
         filing fee is calculated and state how it was determined):

           ____________________________________

      4) Proposed maximum aggregate value of transaction:

           _____________________________________

      5) Total fee paid:

           _____________________________________

[ ]  Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided by Exchange  Act Rule
0-11(a)(2)  and  identify  the  filing  for  which the  offsetting  fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the Form or Schedule and the date of its filing.

      1) Amount Previously Paid:

          _______________________________
1
      2) Form, Schedule or Registration Statement No.:

          _______________________________

      3) Filing Party:

          _______________________________

      4) Date Filed:

          _______________________________


<PAGE>


                                  BioTime, Inc
                               935 Pardee Street
                               Berkeley, CA 94710
                                 (510)845-9535
                               FAX (510)845-7914


                                                   June 13, 2000


Dear Shareholder:


         You are  cordially  invited  to  attend  the  1999  Annual  Meeting  of
Shareholders  of BioTime,  Inc.  which will be held on Monday,  July 17, 2000 at
10:00 a.m. at The  Ritz-Carlton  Hotel,  600  Stockton  Street,  San  Francisco,
California.

         The Notice and Proxy  Statement on the following  pages contain details
concerning  the business to come before the meeting.  Management  will report on
current  operations and there will be an opportunity  for discussion  concerning
the  Company and its  activities.  Please sign and return your proxy card in the
enclosed  envelope to ensure that your shares will be  represented  and voted at
the  meeting  even if you  cannot  attend.  You are urged to sign and return the
enclosed proxy card even if you plan to attend the meeting.

         I look forward to personally  meeting all  shareholders who are able to
attend.




                                           /s/Paul Segall
                                           Paul Segall, Ph. D.
                                           Chairman and Chief Executive Officer



<PAGE>


                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS

                            To Be Held July 17, 2000

         NOTICE IS HEREBY  GIVEN that the  Annual  Meeting  of  Shareholders  of
BioTime,  Inc.  (the  "Company")  will be held at The  Ritz-Carlton  Hotel,  600
Stockton Street, San Francisco,  California,  on July 17, 2000 at 10:00 a.m. for
the following purposes:

         1. To elect eight (8) directors of the Company to hold office until the
         next  Annual  Meeting  of  Shareholders   and  until  their  respective
         successors are duly elected and qualified;

         2.  To  ratify  the  appointment  of  Deloitte  &  Touche  LLP  as  the
         independent  accountants  of the  Company  for the fiscal  year  ending
         December 31, 2000; and

         3. To  transact  such other  business as may  properly  come before the
         meeting or any adjournments of the meeting.

      The Board of Directors has fixed the close of business on Monday,  May 22,
2000, as the record date for determining shareholders entitled to receive notice
of and to vote at the Annual Meeting or any postponement or adjournment thereof.

      Whether or not you expect to attend the  meeting in person,  you are urged
to sign and date the enclosed  form of proxy and return it promptly so that your
shares of stock may be  represented  and voted at the meeting.  If you should be
present at the meeting, your proxy will be returned to you if you so request.

                                       By Order of the Board of Directors,


                                       /s/Judith Segall
                                       Judith Segall
                                       Vice President and Secretary

Berkeley, California
June 13, 2000




<PAGE>



                                 PROXY STATEMENT

                         ANNUAL MEETING OF SHAREHOLDERS

                           To Be Held on July 17, 2000

      The accompanying  proxy is solicited by the Board of Directors of BioTime,
Inc., a California corporation (the "Company" or "BioTime") having its principal
offices at 935 Pardee Street, Berkeley,  California 94710, for use at the Annual
Meeting of  Shareholders of the Company (the "Meeting") to be held at 10:00 a.m.
on Monday,  July 17, 2000 at The Ritz-Carlton  Hotel,  600 Stockton Street,  San
Francisco,  California.  Properly executed proxies in the accompanying form that
are  received  at or before the  Meeting  will be voted in  accordance  with the
directions noted on the proxies. If no direction is indicated,  such shares will
be voted FOR (1) each nominee for election as director,  and (2) approval of the
appointment of Deloitte & Touche LLP as independent  accountants for the Company
for the fiscal year ending December 31, 2000.

      The enclosed proxy confers discretionary authority to vote with respect to
any and all of the  following  matters  that may come  before the  Meeting:  (1)
matters that the Company's  Board of Directors  does not know a reasonable  time
before  the  Meeting  are  to be  presented  at the  Meeting;  and  (2)  matters
incidental to the conduct of the Meeting.  Management does not intend to present
any business  for a vote at the Meeting  other than the matters set forth in the
accompanying  Notice of Annual  Meeting of  Shareholders,  and as of the date of
this Proxy  Statement,  no  shareholder  has  notified  the Company of any other
business that may properly come before the meeting.  If other matters  requiring
the vote of the  shareholders  properly come before the Meeting,  then it is the
intention of the persons  named in the attached  form of proxy to vote the proxy
held by them in accordance with their judgment on such matters.

      Only  shareholders  of record at the close of business on Monday,  May 22,
2000 are entitled to notice of and to vote at the Meeting.  On that date,  there
were  10,891,823 of the Company's  Common Shares issued and  outstanding,  which
constitutes the only class of voting securities of the Company outstanding. Each
of the  Company's  Common  Shares is  entitled  to one vote in the  election  of
directors and in all other matters that may be acted upon at the Meeting, except
that  shareholders  may elect to cumulate  votes in the  election of  directors.
Under  cumulative  voting,  each  shareholder  may  give one  candidate,  or may
distribute among two or more  candidates,  a number of votes equal to the number
of  directors to be elected  multiplied  by the number of Common  Shares  owned.
Shareholders may not cumulate votes unless at least one shareholder gives notice
of his or her  intention to cumulate  votes at the Meeting.  The enclosed  proxy
confers discretionary authority to cumulate votes.

      Any  shareholder  giving a proxy has the power to revoke that proxy at any
time before it is voted.  A proxy may be revoked by filing with the Secretary of
the Company either a written  revocation or a duly executed proxy bearing a date
subsequent to the date of the proxy being revoked, or by voting in person at the
Meeting.  Any shareholder may attend the Meeting and vote in person,  whether or
not such  shareholder  has previously  submitted a proxy,  but attendance at the
Meeting will not revoke a proxy unless the shareholder votes in person.

                                        1


<PAGE>



      The Company will bear all of the costs of the  solicitation of proxies for
use at the  Meeting.  In  addition  to the  use  of the  mails,  proxies  may be
solicited by a personal interview, telephone and telegram by directors, officers
and  employees  of the  Company,  who will  undertake  such  activities  without
additional  compensation.   Banks,  brokerage  houses  and  other  institutions,
nominees or fiduciaries  will be requested to forward the proxy materials to the
beneficial  owners of the  Common  Shares  held of record  by such  persons  and
entities  and will be  reimbursed  for  their  reasonable  expense  incurred  in
connection with forwarding such material.

      This Proxy  Statement and the  accompanying  form of proxy are first being
sent or given to the Company's shareholders on or about June 13, 2000.

                              ELECTION OF DIRECTORS

      At the  Meeting,  eight  directors  will be elected  to hold  office for a
one-year  term until the 2000 Annual  Meeting of  Shareholders,  and until their
successors have been duly elected and qualified. All of the nominees named below
are incumbent directors.

      It is the  intention of the persons  named in the enclosed  proxy,  unless
such proxy specifies otherwise, to vote the shares represented by such proxy FOR
the  election of the  nominees  listed  below.  In the  unlikely  event that any
nominee  should be unable to serve as a director,  proxies may be voted in favor
of a substitute nominee designated by the Board of Directors.

Directors and Nominees

      Paul Segall,  Ph.D.,  57, is the Chairman and Chief Executive  Officer and
has served as a director of the Company since 1990. Dr. Segall  received a Ph.D.
in Physiology from the University of California at Berkeley in 1977.

      Ronald S. Barkin,  54, became  President of BioTime  during  October 1997,
after serving as Executive Vice President  since April 1997. Mr. Barkin has been
a director of the Company since 1990.  Before  becoming an executive  officer of
the Company, Mr. Barkin practiced civil and corporate law for more than 25 years
after getting a J.D. from Boalt Hall, University of California at Berkeley.

      Victoria  Bellport,  34, is the Chief Financial Officer and Vice President
and has been a director of the Company since 1990. Ms. Bellport  received a B.A.
in Biochemistry from the University of California at Berkeley in 1988.

      Hal Sternberg, Ph.D., 46, is the Vice President of Research and has been a
director of the Company since 1990. Dr.  Sternberg was a visiting  scientist and
research  Associate at the University of California at Berkeley from  1985-1988,
where he supervised a team of  researchers  studying  Alzheimer's  Disease.  Dr.
Sternberg  received his Ph.D. from the University of Maryland in Biochemistry in
1982.


                                        2


<PAGE>



      Harold  Waitz,  Ph.D.,  58,  is the  Vice  President  of  Engineering  and
Regulatory  Affairs  and has been a  director  of the  Company  since  1990.  He
received his Ph.D.  in  Biophysics  and Medical  Physics from the  University of
California at Berkeley in 1983.

      Judith Segall, 46, is the Vice President of Technology and Secretary,  and
has been a director of the Company from 1990 through 1994, and from 1995 through
the present date. Ms. Segall received a B.S. in Nutrition and Clinical Dietetics
from the University of California at Berkeley in 1989.

      Jeffrey B. Nickel,  Ph.D.,  55, has been a director of the Company  during
since 1997.  Dr. Nickel is the President of Nickel  Consulting  through which he
has served as a consultant to companies in the  pharmaceutical and biotechnology
industries  since 1990.  Prior to starting his consulting  business,  Dr. Nickel
served in a number of management  positions for Syntex  Corporation  and Merck &
Company.  Dr.  Nickel  received  his Ph.D.  in Organic  Chemistry  from  Rutgers
University in 1970.

      Milton H. Dresner,  74, has been a director of the Company since 1998. Mr.
Dresner is Co- Chairman of the Highland  Companies,  a diversified  organization
engaged in the  development  and ownership of residential  and  industrial  real
estate. Mr. Dresner serves as a director of Avatar Holdings, Inc., a real estate
development  company,  and  Childtime  Learning  Centers,  Inc. a child care and
pre-school education services company.

Executive Officers

      Paul Segall, Ronald S. Barkin,  Victoria Bellport,  Hal Sternberg,  Harold
Waitz and Judith Segall are the only executive officers of BioTime.

      There are no family  relationships  among the directors or officers of the
Company, except that Paul Segall and Judith Segall are husband and wife.

Directors' Meetings, Compensation and Committees of the Board

      The Board of Directors  has an Audit  Committee,  the members of which are
Jeffrey  Nickel and Milton  Dresner.  The purpose of the Audit  Committee  is to
recommend the  engagement of the  Company's  independent  auditors and to review
their  performance,  the plan, scope and results of the audit, and the fees paid
to the corporation's  independent auditors. The Audit Committee also will review
the Company's accounting and financial reporting procedures and controls and all
transactions between the Company and its officers,  directors,  and shareholders
who beneficially own 5% or more of the Common Shares.

      The Company does not have a standing Nominating Committee. Nominees to the
Board of Directors are selected by the entire Board.

      The Board of Directors has a Stock Option  Committee that  administers the
Company's  1992 Stock Option Plan and makes grants of options to key  employees,
consultants,  scientific  advisory board members and independent  contractors of
the Company, but not to officers or directors of the

                                        3


<PAGE>



Company.  The members of the Stock Option Committee are Paul Segall, Ronald S.
Barkin, and Victoria Bellport.  The Stock Option Committee was formed during
September 1992.

       During the fiscal year ended  December 31,  1999,  the Board of Directors
met nine times. No director attended fewer than 75% of the meetings of the Board
or any committee on which they served.

       Directors of the Company who are not  employees  receive an annual fee of
$20,000,  which may be paid in cash or in Common Shares,  at the election of the
director.  During the year ended December 31, 1999,  each director who was not a
Company  employee  also  received  options to  purchase  10,000  Common  Shares.
Directors of the Company and members of committees of the Board of Directors who
are  employees of the Company are  compensated  as employees  but do not receive
additional  compensation  for serving as directors or attending  meetings of the
Board or committees of the Board.  Directors are entitled to reimbursements  for
their  out-of-pocket  expenses  incurred in  attending  meetings of the Board or
committees of the Board.

Executive Compensation

       The  Company  has  entered  into  five-year  employment  agreements  (the
"Employment  Agreements")  with Paul Segall,  the  Chairman and Chief  Executive
Officer;  Victoria Bellport,  the Chief Financial Officer;  Judith Segall,  Vice
President of Technology and Corporate Secretary;  Hal Sternberg,  Vice President
of Research;  and Harold Waitz,  Vice  President of  Engineering  and Regulatory
Affairs.  The  Employment  Agreements  will expire on December  31, 2000 but may
terminate  prior to the end of the term if the employee (1) dies, (2) leaves the
Company,  (3) becomes disabled for a period of 90 days in any 150 day period, or
(4) is  discharged  by the  Board of  Directors  for  failure  to carry  out the
reasonable policies of the Board, persistent  absenteeism,  or a material breach
of a  covenant.  Under the  Employment  Agreements,  as amended,  the  executive
officers are presently receiving an annual salary of $163,000,  and will receive
a one-time cash bonus of $25,000 if the Company  receives at least $1,000,000 of
equity financing from a pharmaceutical company.

       In the event of an  executive  officer's  death during the term of his or
her  Employment  Agreement,  the  Company  will pay his or her estate his or her
salary for a period of six months or until  December  31, 2000, whichever  first
occurs.  In  the  event  that  an  executive  officer's  employment  terminates,
voluntarily or  involuntarily,  after a change in control of the Company through
an acquisition of voting stock,  an  acquisition of the Company's  assets,  or a
merger or consolidation of the Company with another  corporation or entity,  the
executive  officer  will be  entitled  to  severance  compensation  equal to the
greater  of (a)  2.99  times  his or her  average  annual  compensation  for the
preceding  five  years and (b) the  balance  of his or her base  salary  for the
unexpired portion of the term of his Employment Agreement.

      The Company also entered into a similar  employment  agreement with Ronald
S. Barkin, which commenced on April 1, 1997 and expires on March 31, 2002.

       Each  executive  officer  has  also  executed  an  Intellectual  Property
Agreement  which  provides  that the  Company  is the  owner  of all  inventions
developed by the executive officer during the course of his or her employment.

                                        4


<PAGE>




Insider Participation in Compensation Decisions

      The Board of Directors  does not have a standing  Compensation  Committee.
Instead, the Board of Directors as a whole approves all executive  compensation.
All of the executive officers of the Company serve on the Board of Directors but
do not vote on  matters  pertaining  to their own  personal  compensation.  Paul
Segall  and  Judith  Segall do not vote on matters  pertaining  to each  other's
compensation.

Board of Directors Report on Executive Compensation

      The compensation  policies implemented by the Board of Directors have been
influenced by the need to attract and retain  executives with the scientific and
management  expertise to conduct the Company's product  development program in a
highly  competitive  industry  dominated  by  larger,  more  highly  capitalized
companies.  Executive  compensation  is also influenced by the cost of living in
the San  Francisco  Bay Area.  Executive  compensation  may be composed of three
major  components:  (i) base salary;  (ii) annual  variable  performance  awards
payable in cash and tied to the Company's attainment of corporate objectives and
the officer's  achievement of personal goals;  and (iii)  long-term  stock-based
incentive  awards  (stock  options)  designed to  strengthen  the  mutuality  of
interests between the executive officers and the Company's shareholders.

      The Company entered into five-year employment  agreements with each of its
executive  officers in order to assure that their  services would continue to be
available  at a  pre-determined  base  salary  during a  critical  period in the
development of the Company's products and technology. The base salaries fixed by
the Employment  Agreements  were raised during May 1999 to bring them within the
median salary range for small to medium market capitalization  biotechnology and
drug development companies in the same geographic area as the Company.

      An annual  bonus may be earned by each  executive  officer  based upon the
achievement of personal and Company performance goals. Because the Company is in
the  development  stage,  the use of  performance  milestones  based upon profit
levels and return on equity as the basis for such incentive compensation has not
been considered appropriate. Instead, the incentive awards have been tied to the
achievement  of  personal  and  corporate   performance   targets.  The  Company
performance goals vary from year to year according to the stage of the Company's
operations.  Important  milestones  that  have been  considered  by the Board of
Directors  in  determining  incentive  bonuses  have  been  (i)  procurement  of
additional capital, (ii) licensing Company products,  (iii) completing specified
research and development  goals, and (iv) achievement of certain  organizational
goals.  Personal  goals are  related to the  functional  responsibility  of each
executive  officer.  The Board of Directors as a whole determines whether or not
each Company  performance  goal has been achieved.  During the fiscal year ended
December  31,  1999,  the Board of  Directors  did not award any cash bonuses or
grant any stock options to the executive officers.

                                        5


<PAGE>



       The  following  table  summarizes  certain  information   concerning  the
compensation  paid to the  Company's  five  most  highly  compensated  executive
officers  during the last three fiscal  years and the six months ended  December
31, 1998.
<TABLE>
                           SUMMARY COMPENSATION TABLE
<CAPTION>
                                                                                         Long-Term Compensation
                                                                                             Stock Options
                                                 Annual Compensation                         -------------
Name and Principal Position                          Year Ended                 Salary($)        Bonus       (Shares)
---------------------------                          ----------                 ---------        -----       --------

<S>                                      <C>                                 <C>              <C>            <C>
Paul Segall                                 December 31, 1999                   $156,000
  Chairman and Chief Executive              December 31, 1998*                  $ 49,500
         Officer                            June 30, 1998                       $ 95,500         $50,000         __
                                            June 30, 1997                       $ 90,583          __             __

Hal Sternberg

   Vice President of Research               December 31, 1999                   $156,000
                                            December 31, 1998*                  $ 49,500
                                            June 30, 1998                       $ 95,500         $25,000         __
                                            June 30, 1997                       $ 90,583         $25,000         __

Harold Waitz                                December 31, 1999                   $156,000
  Vice President of Engineering and         December 31, 1998*                  $ 49,500
         Regulatory Affairs                 June 30, 1998                       $ 95,500         __              __
                                            June 30, 1997                       $ 90,583         $50,000         __

Victoria Bellport                           December 31, 1999                   $156,000
   Vice President and                       December 31, 1998*                  $ 49,500
    Chief Financial Officer                 June 30, 1998                       $ 95,500         $25,000         __
                                            June 30, 1997                       $ 90,583         $25,000         __

Judith Segall                               December 31, 1999                   $156,000
   Vice President and Corporate             December 31, 1998*                  $ 49,500
         Secretary                          June 30, 1998                       $ 95,500         $25,000         __
                                            June 30, 1997                       $ 90,583         $25,000         __

<FN>
*During 1998,  the Company  changed its fiscal year end from June 30 to December
31. The  amounts of base salary  shown in the table for the year ended  December
31, 1998 reflect a short (six month) fiscal year.
</FN>
</TABLE>

                                        6


<PAGE>



Stock Options

         None of the five  most  highly  compensated  executive  officers of the
Company held any stock options during the fiscal year ended December 31, 1999.

Certain Relationships and Related Transactions

          During the fiscal year ended  December 31,  1999,  $19,125 in fees for
consulting  services  was paid to  Jeffrey B.  Nickel,  a member of the Board of
Directors.

         During  September  1995,  the Company  entered  into an  agreement  for
financial  advisory  services with Greenbelt Corp., a corporation  controlled by
Alfred D.  Kingsley and Gary K.  Duberstein.  Under this  agreement  the Company
issued to the financial  advisor warrants to purchase 311,276 Common Shares at a
price of $1.93 per share, and the Company agreed to issue additional warrants to
purchase  up to an  additional  622,549  Common  Shares at a price  equal to the
greater of (a) 150% of the average  market price of the Common Shares during the
three  months prior to issuance and (b) $2 per share.  The  additional  warrants
were issued in equal quarterly  installments  over a two year period,  beginning
October 15, 1995.  The exercise  price and number of Common Shares for which the
warrants may be exercised are subject to  adjustment to prevent  dilution in the
event of a stock split, combination, stock dividend, reclassification of shares,
sale of assets,  merger or similar transaction.  The warrants are exercisable at
the  following  prices:  466,912 at $1.93 per share;  77,818 at $2.35 per share;
77,818 at $9.65 per  share;  77,818 at $9.42  per  share;  77,818 at $10.49  per
share; 77,818 at $15.74 per share; and 77,818 at $13.75 per share. The number of
shares  and  exercise   prices  shown  have  been  adjusted  for  the  Company's
subscription  rights  distribution during January 1997 and February 1999 and the
payment of a stock dividend during October 1997.

         Under the agreement,  upon the request of Greenbelt  Corp., the Company
will file a  registration  statement to register  the  warrants  and  underlying
Common Shares for sale under the  Securities Act of 1933, as amended (the "Act")
and  applicable  state  securities or "Blue Sky" laws. The Company will bear the
expenses of  registration,  other than any  underwriting  discounts  that may be
incurred by Greenbelt  Corp. in connection with a sale of the warrants or Common
Shares.  The  Company  shall  not be  obligated  to  file  more  than  two  such
registration  statements,  other  than  registration  statements  on  Form  S-3.
Greenbelt  Corp.  also is entitled to include  warrants and Common Shares in any
registration  statement  filed by the Company to register  other  securities for
sale under the Act.

         During April 1998,  the Company  entered into a new financial  advisory
services  agreement  with  Greenbelt  Corp.  The new  agreement  provides for an
initial payment of $90,000 followed by an advisory fee of $15,000 per month that
will be paid  quarterly.  The  agreement  expired on March 31,  2000,  and a new
agreement is being negotiated.

         The Company has agreed to reimburse  Greenbelt  Corp.  for all
reasonable out-of-pocket expenses incurred in connection with its engagement as
financial advisor,  and  to  indemnify  Greenbelt  Corp.  and  the  officers,
affiliates, employees, agents, assignees, and controlling person of Greenbelt
Corp. from
                                        7


<PAGE>



any liabilities  arising out of or in connection with actions taken on behalf of
the Company under the agreement.

Comparison of Shareholder Return

         The graph depicted below reflects a comparison of the cumulative  total
return (change in stock price plus  reinvestment  of dividends) of the Company's
Common  Shares with the  cumulative  total  returns of the Nasdaq  Stock  Market
Index, the BioCentury 100 Stock Index,  and the Hambrecht & Quist  Biotechnology
Index.  The BioCentury 100 Stock Index includes many companies in an early stage
of development that have a market capitalization similar to BioTime's. The graph
covers  the  period  from July 1,  1994,  the first day of the  Company's  fifth
preceding fiscal year, through the fiscal year ended December 31, 1999.

                                 [GRAPH]

         The  graph  assumes  that  $100  was  invested  on July 1,  1994 in the
Company's  Common  Shares  and  in  each  index  and  that  all  dividends  were
reinvested. No cash dividends have been declared on the Company's Common Shares.
<TABLE>
<CAPTION>


                          7/1/94      6/30/95        6/30/96        6/30/98        6/30/98        12/31/98         12/31/99
                          ------      -------        -------        --------       -------        --------         --------
<S>                    <C>         <C>            <C>            <C>             <C>           <C>               <C>
BioTime, Inc.             100.00       56.01         728.02         1,056.03        600.62        1,669.71          852.87
BioCentury 100 index      100.00      113.83         180.44           191.53        174.39          196.70          389.52
NASDAQ Index-US           100.00      133.43         171.31           208.34        274.31          321.46          580.75
H&Q Biotech               100.00      135.05         175.64           183.31        196.69          279.69          597.85
</TABLE>


                                       8
<PAGE>



                             PRINCIPAL SHAREHOLDERS

         The  following  table  sets  forth  information  as  of  June  1,  2000
concerning  beneficial  ownership of Common Shares by each shareholder  known by
the Company to be the  beneficial  owner of 5% or more of the  Company's  Common
Shares,  and  the  Company's  executive  officers  and  directors.   Information
concerning  certain  beneficial  owners of more than 5% of the Common  Shares is
based upon information disclosed by such owners in their reports on Schedule 13D
or Schedule 13G.

                                             Number of         Percent of
                                               Shares             Total
                                             ---------         ----------
Alfred D. Kingsley (1)
Gary K. Duberstein
Greenbelt Corp.
Greenway Partners, L.P.
Greenhouse Partners, L.P.
  277 Park Avenue, 27th Floor
  New York, New York 10172                   1,405,642            11.9%

Paul and Judith Segall (2)                    745,408              6.8

Harold D. Waitz (3)                           524,166              4.8

Hal Sternberg                                 502,043              4.6

Victoria Bellport                             205,978              1.9

Ronald S. Barkin (4)                          192,761              1.7

Jeffrey B. Nickel (5)                         35,000                *

Milton H. Dresner (6)                         39,497                *

All officers and directors
as a group (8 persons)(4)(5)(6)              2,244,853            20.3%
---------------------------

*        Less than 1%

(1)   Includes  933,825 Common Shares  issuable upon the exercise of certain
      warrants owned  beneficially  by Greenbelt  Corp. and 59,730 Common Shares
      owned by Greenbelt Corp. Mr. Kingsley and Mr.  Duberstein may be deemed to
      beneficially  own the warrant  shares that  Greenbelt  Corp.  beneficially
      owns. Includes 90,750 Common Shares owned by Greenway

                                        9


<PAGE>



      Partners,  L.P.  Greenhouse  Partners,  L.P.  is the  general  partner  of
      Greenway  Partners,  L.P.  and Mr.  Kingsley  and Mr.  Duberstein  are the
      general partners of Greenhouse Partners,  L.P. Greenhouse Partners,  L.P.,
      Mr.  Kingsley and Mr.  Duberstein  may be deemed to  beneficially  own the
      Common Shares that Greenway Partners,  L.P.  beneficially  owns.  Includes
      310,442  Common  Shares  owned  solely  by Mr.  Kingsley,  as to which Mr.
      Duberstein disclaims beneficial  ownership.  Includes 10,895 Common Shares
      owned  solely  by Mr.  Duberstein,  as to  which  Mr.  Kingsley  disclaims
      beneficial ownership.

(2)   Includes  543,245  shares  held of record by Paul  Segall and 202,163
      shares held of record by Judith Segall.

(3)   Includes 2,100 shares held for the benefit of Dr. Waitz's minor children.

(4)   Includes 135,000 Common Shares issuable upon the exercise of certain
      options.

(5)   Includes 35,000 Common Shares issuable upon the exercise of certain
      options.

(6)   Includes 20,000 Common Shares issuable upon the exercise of certain
      options. Does not include Common Shares that Mr. Dresner may acquire in
      lieu of cash payment of his director's fees.


      COMPLIANCE WITH SECTION 16(a) OF THE SECURITIES EXCHANGE ACT OF 1934

         Section 16(a) of the  Securities  Exchange Act of 1934, as amended (the
"Exchange  Act"),  requires the Company's  directors and executive  officers and
persons  who own  more  than ten  percent  (10%)  of a  registered  class of the
Company's equity securities to file with the Securities and Exchange  Commission
(the "SEC") initial  reports of ownership and reports of changes in ownership of
Common Shares and other equity  securities of the Company.  Officers,  directors
and greater than ten percent beneficial owners are required by SEC regulation to
furnish the Company with copies of all reports they file under Section 16(a).

         To the Company's knowledge, based solely on its review of the copies of
such reports furnished to the Company and written  representations that no other
reports were required,  all Section 16(a) filing requirements  applicable to its
officers, directors and greater than ten percent beneficial owners were complied
with during the fiscal year ended December 31, 1999.

                                       10

<PAGE>



            RATIFICATION OF THE SELECTION OF INDEPENDENT ACCOUNTANTS

         The Board of Directors  proposes and recommends  that the  shareholders
ratify  the  selection  of the  firm  of  Deloitte  &  Touche  LLP to  serve  as
independent  accountants of the Company for the fiscal year ending  December 31,
2000. Deloitte & Touche LLP has served as the Company's independent  accountants
since 1991. Unless otherwise directed by the shareholders, proxies will be voted
FOR approval of the  selection  of Deloitte & Touche LLP to audit the  Company's
consolidated  financial  statements.  A representative  of Deloitte & Touche LLP
will attend the Meeting,  and will have an opportunity to make a statement if he
or she so desires and may respond to appropriate questions from shareholders.

 The Board of Directors Recommends a Vote "FOR" Ratification of the Selection of
         Deloitte & Touche LLP as the Company's Independent Accountants


                            PROPOSALS OF SHAREHOLDERS

         Shareholders of the Company who intend to present a proposal for action
at the 2000  Annual  Meeting of  Shareholders  of the  Company  must  notify the
Company's  management  of such  intention  by notice  received at the  Company's
principal  executive  offices not later than March 20, 2001 for such proposal to
be included in the Company's  proxy statement and form of proxy relating to such
meeting.

                                  ANNUAL REPORT

         The Company's  Annual Report on Form 10-K filed with the Securities and
Exchange  Commission  for the  fiscal  year ended  December  31,  1999,  without
exhibits,  may be obtained by a shareholder without charge, upon written request
to the Secretary of the Company.

                                           By Order of the Board of Directors,


                                           /s/Paul Segall
                                           Paul Segall, Ph.D.
                                           Chairman and Chief Executive Officer


June 13, 2000

                                       11


<PAGE>


                        HOW TO ATTEND THE ANNUAL MEETING

         If you are a  "shareholder  of record"  (meaning  that you have a stock
certificate registered in your own name), your name will appear on the Company's
shareholder  list.  You will be admitted to the Meeting  upon showing your proxy
card, driver's license, or other identification.

         If you are a "street  name"  shareholder  (meaning that your shares are
held in an  account  at a  broker-dealer  firm) your name will not appear on the
Company's  shareholder  list. If you plan to attend the Meeting,  you should ask
your broker for a "legal  proxy." You will be admitted to the Meeting by showing
your legal proxy. You probably received a proxy form from your broker along with
your proxy statement, but that form can only be used by your broker to vote your
shares,  and it is not a "legal  proxy" that will permit you to vote your shares
directly at the Meeting. If you cannot obtain a legal proxy in time, you will be
admitted  to the  Meeting  if you  bring a copy of your  most  recent  brokerage
account  statement  showing that you own BioTime stock.  However,  if you do not
obtain a legal proxy, you can only vote your shares by returning to your broker,
before the Meeting, the proxy form that accompanied your proxy statement.

                                       12
<PAGE>



                             PROXY FOR BIOTIME, INC.
                         ANNUAL MEETING OF SHAREHOLDERS

                                  July 17, 2000

                This Proxy is Solicited by the Board of Directors

         The undersigned  appoints Paul Segall and Ronald S. Barkin, and each of
them, with full power of  substitution,  as the  undersigned's  lawful agent and
proxy to attend the Annual Meeting of Shareholders of BioTime,  Inc. on July 17,
2000 and any  adjournment  thereof and to represent  and vote all BioTime,  Inc.
Common  Shares  standing  in the name of the  undersigned  upon the books of the
corporation.

DIRECTORS RECOMMEND A VOTE "FOR" PROPOSALS NUMBERED 1 AND 2

1)  ELECTION OF  [ ]   FOR all nominees listed    [ ]  WITHHOLD AUTHORITY  [ ]
    DIRECTORS          at right (except as marked      to vote for all
                       to the contrary below)          nominees listed at right.



NOMINEES: RONALD S. BARKIN; VICTORIA BELLPORT; MILTON H. DRESNER;
JEFFREY B. NICKEL; JUDITH SEGALL; PAUL SEGALL; HAL STERNBERG; HAROLD WAITZ

**To withhold authority to vote for any individual nominee, draw a line through
  that person's name**

                                              FOR         AGAINST       ABSTAIN



2) RATIFYING THE APPOINTMENT OF INDEPENDENT   [ ]           [ ]           [ ]
   ACCOUNTANTS

               The  persons  named  as proxy  may also  vote on
                such other  business as may  properly  come
                before  the  Meeting  or  any   adjournment
                thereof.


                        [ ]     WISH TO ATTEND AND
                                VOTE SHARES AT MEETING


Please sign exactly as
your shares are registered.       _______________________     __________________
Persons signing as a corporate    Signature                         Date
officer or in a fiduciary
capacity should indicate their    _________________________   __________________
title or capacity.                Signature if Held Jointly         Date




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