SYSTEMIX INC /DE
SC 13D/A, 1996-10-30
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

- --------------------------------------------------------------------------------


                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                                 Amendment No. 8

                                 SYSTEMIX, INC.
               -------------------------------------------------
                                (Name of Issuer)

                     Common Stock, Par Value $.01 Per Share
               -------------------------------------------------
                         (Title of Class of Securities)

                                   871872 10 7
               -------------------------------------------------
                      (CUSIP Number of Class of Securities)

                             Robert L. Thompson, Jr.
                       Vice President and General Counsel
                               Sandoz Corporation
                                608 Fifth Avenue
                            New York, New York 10020
                            Telephone: (212) 830-2413
               -------------------------------------------------
                       (Name, Address and Telephone Number
                     of Person Authorized to Receive Notices
                               and Communications)

                                    Copy to:
                             David W. Heleniak, Esq.
                               Shearman & Sterling
                              599 Lexington Avenue
                            New York, New York 10022
                                 (212) 848-4000

                                October 29, 1996
               -------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13-d-1(b)(3) or (4), check the following box. |_|

Check the following box if a fee is being paid with this statement.  |_|




                               Page 1 of 11 Pages

<PAGE>



CUSIP No. 871872 10 7

(1)      Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Person

            SANDOZ BIOTECH HOLDINGS CORPORATION
- --------------------------------------------------------------------------------

(2)      Check the Appropriate Box if a member of a Group


    (a)       |_|
            --------------------------------------------------------------------

    (b)       |X|
            --------------------------------------------------------------------




(3)      SEC Use Only
                     -----------------------------------------------------------
         -----------------------------------------------------------------------

(4)      Source of Funds                    AF
                        --------------------------------------------------------
         -----------------------------------------------------------------------

(5)      Check if Disclosure of Legal Proceedings is Required
         Pursuant to Item 2(d) or 2(e).  |_|
                                       -----------------------------------------

(6)      Citizenship or Place of Organization        Delaware
                                             -----------------------------------
         -----------------------------------------------------------------------

- ---------------
                       (7)    Sole Voting Power
  Number of                                    ---------------------------------
    Shares
 Beneficially          (8)    Shared Voting Power                 11,977,699
  Owned by                                       -------------------------------
    Each
  Reporting            (9)    Sole Dispositive Power
   Person                                           ----------------------------
    With
                       (10)   Shared Dispositive Power            11,977,699
- ---------------                                        -------------------------
 

(11)     Aggregate Amount Beneficially Owned by Each
         Reporting Person                                          11,977,699
                                                    ----------------------------

(12)     Check if the Aggregate Amount in Row (11) Excludes Certain Shares   |_|


(13)     Percent of Class Represented by Amount in Row (11)
                                            76%
         -----------------------------------------------------------------------
(14)     Type of Reporting Person                    CO
                                 -----------------------------------------------

                               Page 2 of 11 Pages


<PAGE>




CUSIP No. 871872 10 7

(1)      Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Person

            SANDOZ LTD.
          ----------------------------------------------------------------------

(2)      Check the Appropriate Box if a member of a Group


    (a)       |_|
            --------------------------------------------------------------------
    (b)       |X|
            --------------------------------------------------------------------


(3)      SEC Use Only
                     -----------------------------------------------------------

(4)      Source of Funds                    WC
                        --------------------------------------------------------

(5)      Check if Disclosure of Legal Proceedings is Required
         Pursuant to Item 2(d) or 2(e).  |_|
                                       -----------------------------------------

(6)      Citizenship or Place of Organization        Switzerland
                                             -----------------------------------

- ---------------
                       (7)    Sole Voting Power
  Number of                                    ---------------------------------
    Shares
 Beneficially          (8)    Shared Voting Power                 11,977,699
  Owned by                                       -------------------------------
    Each
  Reporting            (9)    Sole Dispositive Power
   Person                                           ----------------------------
    With
                       (10)   Shared Dispositive Power            11,977,699
- ---------------                                        -------------------------

(11)     Aggregate Amount Beneficially Owned by Each
         Reporting Person                                          11,977,699
                                                    ----------------------------

(12)     Check if the Aggregate Amount in Row (11) Excludes Certain Shares   |_|
                                                                          ------

(13)     Percent of Class Represented by Amount in Row (11)
                                            76%
         -----------------------------------------------------------------------
(14)     Type of Reporting Person                    CO
                                 -----------------------------------------------

                               Page 3 of 11 Pages


<PAGE>




                  This Amendment No. 8 amends and  supplements  the Statement on
Schedule 13D, filed with the Securities and Exchange  Commission on December 20,
1991, as amended by Amendment Nos. 1 through 7 thereto (the "Schedule  13D"), by
Sandoz Biotech Holdings Corporation, a Delaware corporation ("Purchaser") and an
indirect wholly owned  subsidiary of Sandoz Ltd., a company  organized under the
laws of Switzerland ("Parent"),  with respect to the shares of common stock, par
value  $.01 per share  (the  "Common  Stock"),  of  SyStemix,  Inc.,  a Delaware
corporation (the "Company").

Item 4.  Purpose of Transaction

                  Item 4 of the Schedule 13D is hereby amended and  supplemented
as follows:

                  On  October  28,  1996,   the  Company   announced   that  the
"independent  directors" of the Company rejected Parent's  previously  announced
offer of May 23,  1996 to  acquire  for US $17 per share all of the  issued  and
outstanding  shares of Common Stock not already owned by Parent. A press release
issued by Parent on October 29, 1996 relating to the foregoing event is attached
as Exhibit 99.1 and is incorporated by reference in its entirety.


Item 7.  Material to be Filed as Exhibits

         Item 7 of the Schedule 13D is hereby amended and supplemented by adding
the following Exhibits:

         Exhibit 24     Power of Attorney.

         Exhibit 99.1   Press Release issued by Parent on October 29, 1996.


                               Page 4 of 11 Pages

<PAGE>

                                    SIGNATURE



                  After reasonable  inquiry and to the best of our knowledge and
belief,  we certify that the  information  set forth in this  statement is true,
complete and correct.

October 30, 1996

                                               SANDOZ LTD.


                                               By:  /s/ Robert L. Thompson, Jr.
                                                    ----------------------------
                                                    Robert L. Thompson, Jr.
                                                    Attorney-in-fact


                                               SANDOZ BIOTECH HOLDINGS
                                                    CORPORATION


                                               By:  /s/ Robert L. Thompson, Jr.
                                                    ----------------------------
                                                    Robert L. Thompson, Jr.
                                                    Vice President


                               Page 5 of 11 Pages

<PAGE>



                                  EXHIBIT INDEX


Exhibit                                                                    

  24              Power of Attorney.


  99.1            Press Release issued by Parent on October 29, 1996.



                               Page 6 of 11 Pages


                                   EXHIBIT 24
                                   ----------

                                POWER OF ATTORNEY



KNOW ALL PERSONS BY THESE PRESENTS:

That Sandoz Ltd., a Swiss corporation  having its principal place of business in
the City of Basle, does hereby make, constitute and appoint:
         Robert L. Thompson, Jr. of 608 Fifth Avenue, New York, New York; and
         Wayne Merkelson of 608 Fifth Avenue, New York, New York,
or any one of them acting alone,  its true and lawful  attorneys,  for it and in
its name, place and stead,  with full power of substitution to represent and act
for it in all matters  pertaining to  submissions to the Securities and Exchange
Commission,  with such changes therein as may be approved by said attorneys,  or
any one of them acting alone,  and in general to do all things and to perform on
the part of Sandoz Ltd.  all acts as said  attorneys,  or any one of them acting
alone,  determines are necessary or advisable in connection with  submissions to
the  Securities  and  Exchange  Commission,   including,  without  limiting  the
generality  of the  foregoing,  the  execution  and  delivery  of all  documents
required under the Securities Exchange Act of 1934, as amended,  all agreements,
officer's  and  other  certificates,   and  any  and  all  other  documents  and
instruments  required,  contemplated  by or deemed  advisable in connection with
this power of attorney and to  otherwise  act for and in the name of Sandoz Ltd.
and in its behalf with respect to the transactions  described herein fully as if
the duly  authorized  officers of Sandoz Ltd. were then  personally  present and
acting.

Sandoz Ltd.  hereby  ratifies  and  confirms  all that said  attorneys  or their
substitutes shall lawfully do, or cause to be does, by virtue hereof.


                               Page 7 of 11 Pages


<PAGE>


                                        2

IN WITNESS  WHEREOF,  Sandoz Ltd. has caused this power of attorney to be signed
by two duly authorized officers this 21st day of May, 1996.

                                           SANDOZ LTD.

                                           /s/ P. Rickli   /s/ R. Breu
                                           ------------------------------------


                               Page 8 of 11 Pages


                                  Exhibit 99.1
                                  ------------
                                  PRESS RELEASE

SANDOZ
CORPORATE COMMUNICATIONS
KOMMUNIKATION KONZERN                                  SANDOZ
COMMUNICATION DU GROUPE
CH-4002 BASEL/SCHWEIZ
 ...........................                            PRESS RELEASE
PRESS OFFICE
OF THE SANDOZ COMPANIES
 ...........................
PRESSEDIENST                        Current Sandoz and designated Novartis
DER SANDOZ-GESELLSCHAFTEN           Heads of Country Organizations
 ...........................
SERVICE DE PRESSE                   Current Sandoz Corporate Communications and
DES SOCIETES SANDOZ                 designated Novartis Corporate Sector and
 ...........................         Country Organization Communicators
TEL. +41-61-324-9001
FAX  +41-61-324-4884



Sandoz' offer to minority shareholders of SyStemix declined


     Basel,  29 October 1996 -- Sandoz Ltd. today announced that its proposal to
acquire all outstanding shares of SyStemix had been declined by the 'independent
directors' of SyStemix on behalf of the minority shareholders.  Announced on May
23 this year, the offer of USD 17 per share originally  represented a premium of
55% over the closing  price prior to the offer.  SyStemix'  shares  closed on 28
October at USD 16.  Sandoz said it was  disappointed  by the  decision but would
study it before taking further action.

     SyStemix, Inc., based in Palo Alto, California,  is a biotechnology company
specializing  in the  development  of new therapies  for major  disorders of the
blood system based on the use of human  hematopoietic stem cells.  Collaboration
between  the two  companies  began  in  1991.  In 1992,  Sandoz  acquired  a 60%
interest, which it increased in 1995 to 71.6% on a fully diluted basis.

     Headquartered in Basel, Switzerland, Sandoz Ltd. is a global research-based
pharmaceuticals  and nutrition group, with further activities in crop protection
and seeds.  In 1995,  Sandoz Group sales  exceeded CHF 15.2 billion.  On 7 March
1996,  Sandoz and  Ciba-Geigy  announced  plans to merge and form a new  company
Novartis.  The plan was approved by each company's  shareholders  on 23 (Sandoz)
and 24 (Ciba) April 1996.  Approval from the European  Commission was granted on
17 July. The merger is still subject to approval by the Federal Trade Commission
(FTC) in the US.

                                            Press Office of the Sandoz Companies


                               Page 9 of 11 Pages



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