SEPRACOR INC /DE/
424B3, 1998-12-30
PHARMACEUTICAL PREPARATIONS
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                                                FILED PURSUANT TO RULE 424(b)(3)
                                                      REGISTRATION NO. 333-51879


PROSPECTUS SUPPLEMENT
(TO PROSPECTUS DATED JUNE 18, 1998)

                                  SEPRACOR INC.

                    ----------------------------------------

               $189,475,000 PRINCIPAL AMOUNT OF 6 1/4% CONVERTIBLE
                        SUBORDINATED DEBENTURES DUE 2005
                  (Interest payable August 15 and February 15)

                    ----------------------------------------

                        4,012,617 Shares of Common Stock
                           ($0.10 par value per share)

                              ---------------------

         The information in this Prospectus Supplement concerning the Selling
Securityholders supplements the statements set forth under the caption "Selling
Securityholders" in the Prospectus. Capitalized items used and not defined
herein shall have the meanings given to them in the Prospectus. The information
set forth under the caption "Selling Securityholders" in the Prospectus is
supplemented as follows:

                             SELLING SECURITYHOLDERS

         The Debentures were originally acquired on February 10, 1998 from the
Company by the Initial Purchasers. The Initial Purchasers advised the Company
that the Initial Purchasers have resold the Debentures in transactions exempt
from the registration requirements of the Securities Act to "qualified
institutional buyers" (as defined in Rule 144A of the Securities Act) and
certain institutional "accredited investors" (as defined in Rule 501(a)(1), (2),
(3), or (7) under the Securities Act). These subsequent purchasers, or their
transferees, pledgees, donees or successors, may from time to time offer and
sell any or all of the Debentures and/or Conversion Shares pursuant to this
Prospectus.

         The Debentures and the Conversion Shares have been registered pursuant
to the Registration Rights Agreement which provides that the Company file a
Registration Statement with regard to the Debentures and the Conversion Shares
within 90 days of the date of original issuance of the Debentures and keep such
Registration Statement effective until the earlier of (i) the sale pursuant to
the Registration Statement of all the securities registered pursuant to the
Registration Rights Agreement thereunder and (ii) the expiration of the holding
period applicable to such securities under Rule 144(k) under the Securities Act
or any successor provision.

         In addition, 12,639 Additional Shares are being registered pursuant to
the Registration Statement for the account of certain securityholders of the
Company. The Selling Securityholders may choose to sell Debentures and/or Shares
from time to time. See "Plan of Distribution."

         Debentures and Conversion Shares. The following table sets forth the
name of each Selling Securityholder who has provided the Company with notice as
of the date of this Prospectus pursuant to the Registration Rights Agreement of
such Selling Securityholder's intent to sell or otherwise dispose of Debentures
and/or Conversion Shares pursuant to the Registration Statement, the principal
amount of Debentures and the number of Conversion Shares which may be sold from
time to time by such Selling Securityholder pursuant to the Registration
Statement and the amount of outstanding Debentures and Common Stock beneficially
owned by such Selling Securityholder prior to the offering (assuming no
conversion of the Debentures). No such Selling Securityholder nor any of its
affiliates


<PAGE>



has held any position or office with, been employed by or otherwise has had any
material relationship with, the Company or any of its affiliates during the
three years prior to the date of this Prospectus. Because the Selling
Securityholder may offer all or some portion of the Debentures and Conversion
Shares, no estimate can be given as to the amount or percentage of Debentures or
Common Stock that will be held by the Selling Securityholders upon termination
of sales pursuant to this Prospectus. In addition, the Selling Securityholders
identified below may have sold, transferred or disposed of all or a portion of
their Debentures since the date on which they provided the information regarding
their holdings in transactions exempt from the registration requirements of the
Securities Act.


<TABLE>
<CAPTION>
                                                                  Amount of                                        Shares of
                                            Amount of             Debentures                                     Common Stock
                                         Debentures that         Owned Before          Shares That May            Owned Before
        Name (1)                           May be Sold             Offering               be Sold(2)                Offering
        --------                          -------------           ----------             ------------              ---------
<S>                                         <C>                    <C>                       <C>                      <C>
ICI American Holdings
Trust                                       $425,000               $425,000                  8,972                     0

Zeneca Holdings Trust                        425,000                425,000                  8,972                     0

State of Delaware PERS                     1,000,000              1,000,000                 21,110                     0

Starvest Fund-
Discretionary                                500,000                500,000                 10,555                     0

State of Oregon/SAIF
Corporation                                4,000,000              4,000,000                 84,443                     0

State of Oregon PERS                       4,500,000              4,500,000                 94,998                     0

Nalco Chemical Corp.
Retirement                                   225,000                225,000                  4,749                     0

Kapiolani Medical
Center for Women and
Children                                     100,000                100,000                  2,111                     0

Hawaiian Airlines
Pension for Salaried
Employees                                     15,000                 15,000                    316                     0

Hawaiian Airlines
Pilots' Retirement Plan                       70,000                 70,000                  1,477                     0

Hawaiian Airlines
Pension Plan - IAM                            50,000                 50,000                  1,055                     0

Allstate Insurance
Company                                    2,000,000              2,000,000                 42,221                     0

Shepard Investments
International Inc.                        14,875,000             14,875,000                314,023                     0




                                        2

<PAGE>




Silverton International
Fund Limited                               4,250,000              4,250,000                 89,721                     0

Nomura Securities
(Bermuda) Ltd.                            10,000,000             10,000,000                211,108                     0

Paloma Securities
L.L.C.                                     4,475,000              4,475,000                 94,471                     0

Ell & Co., as nominee
for The Northern Trust
Company of New York                          580,000                580,000                 12,244                     0

Salkeld & Co., as
nominee for Bankers
Trust Company                                615,000                615,000                 12,983                     0

Bankers Trust
Company                                    1,500,000              1,500,000                 31,666                     0

Bear Stearns Securities
Corp.                                      1,500,000              1,500,000                 31,666                     0

The Income Fund of
America, Inc.                              7,350,000              7,350,000                155,164                     0

The TCW Group, Inc.                       12,315,000             12,315,000                259,980                     0

Deutsche Bank AG                          12,105,000             12,105,000                255,546                     0

Morgan Stanley Dean
Witter                                     2,045,000              2,045,000                 43,171                     0

Colonial Penn Life
Insurance Company                          2,000,000              2,000,000                 42,221                     0

OCM Convertible Trust                      3,575,000              3,575,000                 75,471                     0

OCM Convertible
Limited Partnership                          100,000                100,000                  2,111                     0

Delta Air Lines Master
Trust                                      1,025,000              1,025,000                 21,638                     0

State Employees'
Retirement Fund of the
State of Delaware                            840,000                840,000                 17,733                     0

State of Connecticut
Combined Investment
Funds                                      3,210,000              3,210,000                 67,765                     0

Vanguard Convertible
Securities Fund, Inc.                      2,200,000              2,200,000                 46,443                     0



                                        3

<PAGE>




Partner Reinsurance
Company Ltd.                                 280,000                280,000                  5,911                     0

Chrysler Corporation
Master Retirement
Trust                                      2,405,000              2,405,000                 50,771                     0

Raytheon Company
Master Pension Trust                       1,115,000              1,115,000                 23,538                     0

Mainstay Convertible
Fund                                       4,750,000              4,750,000                100,276                     0

Century National
Insurance Company                            425,000                425,000                  8,972                     0

Chrysler Insurance
Company -Total Return                         30,000                 30,000                    633                     0

AAM/Zazove
Institutional Income
Fund L.P.                                  2,500,000              2,500,000                 52,777                     0

Zazove Convertible
Fund L.P.                                    745,000                745,000                 15,727                     0

McMahan Securities
Company L.P.                                 390,000                390,000                  8,233                     0

Stephenson Ventures                          500,000                500,000                 10,555                     0

Delaware State
Employees' Retirement
Fund                                       3,300,000              3,300,000                 69,665                     0

Declaration of Trust for
the Defined Benefit
Plans of ICI American
Holdings, Inc.                             1,030,000              1,030,000                 21,744                     0

Declaration of Trust for
the Defined Benefit
Plans of Zeneca
Holdings Inc.                                700,000                700,000                 14,777                     0

Thermo Electron
Balanced Investment
Fund                                         950,000                950,000                 20,055                     0

Hillside Capital
Incorporated Corporate
Account                                      330,000                330,000                  6,966                     0




                                        4

<PAGE>




General Motors
Employees Domestic
Group Trust                               11,630,000             11,630,000                245,519                     0

Summer Hill Global
Partners L.P.                                 80,000                 80,000                  1,688                     0

The J.W. McConnell
Family Foundation                            380,000                380,000                  8,022                     0

TQA Vantage Fund
Ltd.                                       1,000,000              1,000,000                 21,110                     0

TQA Arbitrage Fund,
L.P.                                         750,000                750,000                 15,833                     0

California Public
Employees' Retirement
System                                     4,000,000              4,000,000                 84,443                     0

Millennium Trading
Co., L.P.                                    185,000                185,000                  3,905                     0

Donaldson, Lufkin &
Jenrette Securities
Corp.                                        220,000                220,000                  4,644                     0

Fidelity Financial Trust:
Fidelity Convertible
Securities Fund (3)                        7,815,000              7,815,000                164,981                     0

Fidelity Securities
Fund:  Fidelity OTC
Portfolio (3)                             14,500,000             14,500,000                306,107                     0

MFS Series Trust I-
MFS Convertible
Securities Fund                                2,000                  2,000                     42                     0

MFS Series Trust V-
MFS Total Return Fund                      1,998,000              1,998,000                 42,179                     0

J. P. Morgan & Co.                         3,000,000              3,000,000                 63,332                81,500

General Motors
Employees Domestic
Group Pension
Trust (4)                                  8,679,000              8,679,000                183,221                47,600

Motors Insurance
Corporation (4)                            2,002,000              2,002,000                 42,263                     0

General Motors
Foundation, Inc. (4)                         319,000                319,000                  6,734                     0




                                        5

<PAGE>




Nicholas-Applegate
Convertible Fund                           2,157,000              2,157,000                 45,536                     0

Nicholas-Applegate
Global Holdings
Company LP                                    70,000                 70,000                  1,477                     0

Baptist Health of South
Florida                                      118,000                118,000                  2,491                     0

Boston Museum of
Fine Arts                                     59,000                 59,000                  1,245                     0

Engineers Joint Pension
Fund                                         218,000                218,000                  4,602                     0

Physicians Life                              450,000                450,000                  9,499                     0

Wake Forest University                       466,000                466,000                  9,837                     0

Dunham &
Associates II                                 41,000                 41,000                    865                     0

Dunham &
Associates III                                22,000                 22,000                    464                     0

San Diego City
Retirement                                   589,000                589,000                 12,434                     0

San Diego County
Convertible                                1,800,000              1,800,000                 37,999                     0

TQA Leverage
Fund, L.P.                                   565,000                565,000                 11,927                     0

Anchor Pathway
Growth-Income Series                       3,650,000              3,650,000                 77,054                     0

GLG Market
Neutral Fund                               2,000,000              2,000,000                 42,221                     0

Putnam Convertible
Income-Growth Trust                        4,880,000              4,880,000                103,020                     0

Putnam Balanced
Retirement Fund                              300,000                300,000                  6,333                     0

Putnam Convertible
Opportunities and
Income Trust                                 390,000                390,000                  8,233                     0

Museum of Fine Arts,
Boston                                        60,000                 60,000                  1,266                     0

Boston College                               100,000                100,000                  2,111                     0




                                        6

<PAGE>




ProMutual                                    500,000                500,000                 10,555                     0

Employers' Reinsurance
Corporation                                  550,000                550,000                 11,610                     0

University of Rochester                      120,000                120,000                  2,533                     0

Rhone-Poulenc Rorer
Pension Plan                                 120,000                120,000                  2,533                     0

Parker-Hannifin
Corporation                                  140,000                140,000                  2,955                     0

Retirement System                            600,000                600,000                 12,666                     0


</TABLE>

- --------------------

(1)  Certain of the Debentures are currently evidenced by a global Debenture
     which has been deposited with DTC and registered in the name of Cede & Co.
     as DTC's nominee. Therefore, the Company is unable to provide the names of
     any remaining Selling Stockholders.

(2)  Assumes conversion of full amount of Debentures held by such holder at the
     initial rate of $47.369 in principal amount of Debentures per share of
     Common Stock.

(3)  Debentures are held in the nominee name of Mag & Co. The entity is either
     an investment company or a portfolio of an investment company registered
     under Section 8 of the Investment Company Act of 1940, as amended, or a
     private investment account advised by Fidelity Management & Research
     Company ("FMR Co."). FMR Co. is a Massachusetts corporation and an
     investment advisor registered under Section 203 of the Investment Advisers
     Act of 1940, as amended, and provides investment advisory services to each
     of such Fidelity entities identified above, and to other registered
     investment companies and to certain other funds which are generally offered
     to a limited group of investors. FMR Co. is a wholly-owned subsidiary of
     FMR Corp. ("FMR"), a Massachusetts corporation. The holdings are as of
     September 2, 1998.

(4)  General Motors Investment Management Corporation, a wholly owned subsidiary
     of General Motors Corporation ("GM"), provides investment advice and
     investment management services with respect to the assets of certain
     employee benefit plans of GM and its subsidiaries, including the General
     Motors Employees Domestic Group Pension Trust, and with respect to the
     assets of certain direct and indirect subsidiaries of GM and associated
     entities, including Motors Insurance Corporation and the General Motors
     Foundation, Inc.

     Additional Shares. Set forth below are the names of certain other Selling
Securityholders who acquired shares of Common Stock in certain transactions not
related to the sale of Debentures and the maximum number of Additional Shares
that may be sold by each such Selling Securityholder from time to time
hereunder. No such Selling Securityholders nor any of their affiliates has held
any position or office with, been employed by or otherwise have had any material
relationship with, the Company or any of its affiliates during the three years
prior to the date of this Prospectus. The percentage of Common Stock
beneficially owned by each of the Selling Securityholders identified below both
prior to and after giving effect to the offering being made hereby is less than
1%.



                                        7

<PAGE>



<TABLE>
<CAPTION>

                               Number of Shares of                                        Number of Shares of
                               Common Stock                 Number of Shares of           Common Stock
                               Beneficially Owned           Common Stock to be            Beneficially Owned
            Name               Prior to this Offering       Offered Hereunder             After this Offering
           ------              -----------------------      -------------------           -------------------
<S>                                     <C>                        <C>                             <C>
Robash Inc.                             243                        243                             0

Beincke Investment                    1,944                      1,944                             0
Fund L.P.

Theodore H. Ashford                   4,243                        243                         4,000

Bedrock Asset Trust I                 7,778                      7,778                             0

Bankers Trust
Company, as Trustee
of the Hughes Aircraft
Company Retirement
Plans                                80,539                      2,431                        78,108

</TABLE>




                    The date of this Prospectus Supplement is
                                December 30, 1998






























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