SEPRACOR INC /DE/
424B3, 1998-07-17
PHARMACEUTICAL PREPARATIONS
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                                               FILED PURSUANT TO RULE 424(b)(3)
                                                     REGISTRATION NO. 333-51879

PROSPECTUS SUPPLEMENT
(TO PROSPECTUS DATED JUNE 18, 1998)

                                  SEPRACOR INC.
                    ----------------------------------------

               $189,475,000 PRINCIPAL AMOUNT OF 6 1/4% CONVERTIBLE
                        SUBORDINATED DEBENTURES DUE 2005
                  (Interest payable August 15 and February 15)
                    ----------------------------------------

                        4,012,617 Shares of Common Stock
                           ($0.10 par value per share)
                              ---------------------

         The information in this Prospectus Supplement concerning the Selling
Stockholders supplements the statements set forth under the caption "Selling
Stockholders" in the Prospectus. Capitalized items used and not defined herein
shall have the meanings given to them in the Prospectus.

                              SELLING STOCKHOLDERS

         The information set forth under the caption "Selling Stockholders" in
the Prospectus is supplemented as follows:


<TABLE>
<CAPTION>
                                                           Amount of                                     Shares of
                                    Amount of              Debentures                                  Common Stock
                                 Debentures that          Owned Before         Shares That May         Owned Before
            Name                   May be Sold              Offering              be Sold(1)             Offering
            ----                 ---------------          ------------         ---------------         -------------
<S>                              <C>                      <C>                  <C>                     <C>
ICI American
Holdings Trust                         $425,000               $425,000                  8,972                     0

Zeneca Holdings Trust                   425,000                425,000                  8,972                     0

State of Delaware
PERS                                  1,000,000              1,000,000                 21,110                     0

Starvest Fund-
Discretionary                           500,000                500,000                 10,555                     0

State of Oregon/SAIF
Corporation                           4,000,000              4,000,000                 84,443                     0

State of Oregon PERS                  4,500,000              4,500,000                 94,998                     0

Nalco Chemical Corp.
Retirement                              225,000                225,000                  4,749                     0



<PAGE>




Kapiolani Medical
Center for Women and
Children                              100,000                100,000                  2,111                     0

Hawaiian Airlines
Pension for Salaried
Employees                              15,000                 15,000                    316                     0

Hawaiian Airlines
Pilots' Retirement Plan                70,000                 70,000                  1,477                     0

Hawaiian Airlines
Pension Plan - IAM                     50,000                 50,000                  1,055                     0

Allstate Insurance
Company                             2,000,000              2,000,000                 42,221                     0

Shepard Investments
International Inc.                 14,875,000             14,875,000                314,023                     0

Silverton International
Fund Limited                        4,250,000              4,250,000                 89,721                     0

Nomura Securities
(Bermuda) Ltd.                     10,000,000             10,000,000                211,108                     0

Paloma Securities
L.L.C.                              4,475,000              4,475,000                 94,471                     0

Ell & Co., as nominee
for The Northern
Trust Company of
New York                              580,000                580,000                 12,244                     0

Salkeld & Co., as
nominee for Bankers
Trust Company                         615,000                615,000                 12,983                     0

Bankers Trust
Company                             1,500,000              1,500,000                 31,662                     0

Bear Stearns Securities
Corp.                               1,500,000              1,500,000                 31,662                     0

The Income Fund of
America, Inc.                       7,350,000              7,350,000                155,164                     0

The TCW Group, Inc.                12,315,000             12,315,000                259,980                     0

Deutsche Bank AG                   12,105,000             12,105,000                255,546                     0

Morgan Stanley Dean
Witter                             96,869,605             96,869,605              2,045,000                     0

Colonial Penn Life
Insurance Company                   2,000,000              2,000,000                 42,221                     0

OCM Convertible
Trust                               3,575,000              3,575,000                 75,471                     0

OCM Convertible
Limited Partnership                   100,000                100,000                  2,111                     0

Delta Air Lines Master
Trust                               1,025,000              1,025,000                 21,638                     0

State Employees'
Retirement Fund of
the State of Delaware                 840,000                840,000                 17,733                     0

State of Connecticut
Combined Investment
Funds                               3,210,000              3,210,000                 67,765                     0

Vanguard Convertible
Securities Fund, Inc.               2,200,000              2,200,000                 46,443                     0
                                  
Partner Reinsurance               
Company Ltd.                          280,000                280,000                  5,911                     0
                                  
Crystler Corporation              
Master Retirement                 
Trust                               2,405,000              2,405,000                 50,771                     0
                                  
Raytheon Company                  
Master Pension Trust                1,115,000              1,115,000                 23,538                     0
- --------------------
</TABLE>

(1)  Assumes conversion of full amount of Debentures held by such holder at the
     initial rate of $47.369 in principal amount of Debentures per share of 
     Common Stock.


                    The date of this Prospectus Supplement is
                                  July 17, 1998









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