SEPRACOR INC /DE/
S-8, 1998-07-06
PHARMACEUTICAL PREPARATIONS
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      As filed with the Securities and Exchange Commission on July 6, 1998
                                                      Registration No. 333-
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                                  SEPRACOR INC.
             (Exact Name of Registrant as Specified in Its Charter)

               Delaware                                    22-2536587
    (State or Other Jurisdiction of                     (I.R.S. Employer
    Incorporation or Organization)                     Identification No.)

                111 Locke Drive, Marlborough, Massachusetts 01752
               (Address of Principal Executive Offices) (Zip Code)

                         1991 DIRECTOR STOCK OPTION PLAN
                            (Full Title of the Plan)

                              Mark G. Borden, Esq.
                                Hale and Dorr LLP
                                 60 State Street
                           Boston, Massachusetts 02109
                     (Name and Address of Agent For Service)

                                 (617) 526-6000
          (Telephone Number, Including Area Code, of Agent For Service)

                         CALCULATION OF REGISTRATION FEE
================================================================================
<TABLE>
<CAPTION>
                                      Proposed         Proposed
    Title of                           maximum         maximum
 securities to be    Amount to be   offering price     aggregate         Amount of
   registered        registered       per share     offering price    registration fee
- ------------------ ---------------- --------------- ----------------  -----------------
<S>                <C>              <C>             <C>                    <C>
Common Stock,
$.10 par value      225,000 shares   $41.25 (1)      $9,281,250 (1)        $2,738
- ---------------------------------------------------------------------------------------
</TABLE>

(1) Estimated solely for the purpose of calculating the registration fee,
    and based upon the average of the high and low prices of the Common
    Stock on the Nasdaq National Market on June 30, 1998 in accordance with
    Rules 457(c) and 457(h) of the Securities Act of 1933.
================================================================================

<PAGE>

Statement of Incorporation by Reference
- ---------------------------------------

         Except as otherwise set forth below, this Registration Statement on
Form S-8 incorporates by reference the contents of the Registration Statements
on Form S-8, File Nos. 33-44808 and 333-5217, relating to the Registrant's 1991
Director Stock Option Plan, as amended.

PART I.  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

         The information required by Part I is included in documents sent or
given to participants in the 1991 Director Stock Option Plan of Sepracor Inc., a
Delaware corporation (the "Registrant"), pursuant to Rule 428(b)(1) under the
Securities Act of 1933, as amended (the "Securities Act").

PART II. INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

         Item 3. Incorporation of Certain Documents by Reference.
                 ------------------------------------------------

         The Registrant is subject to the informational and reporting
requirements of Sections 13(a), 14, and 15(d) of the Securities and Exchange Act
of 1934, as amended (the "Exchange Act"), and in accordance therewith files
reports, proxy statements and other information with the Securities and Exchange
Commission. The following documents, which are filed with the Securities and
Exchange Commission, are incorporated in this Prospectus by reference:

                  (1) The Registrant's latest annual report filed pursuant to
         Section 13(a) or 15(d) of the Exchange Act, or the latest prospectus
         filed pursuant to Rule 424(b) under the Securities Act, that contains
         audited financial statements for the Registrant's latest fiscal year
         for which such statements have been filed.

                  (2) All other reports filed pursuant to Section 13(a) or 15(d)
         of the Exchange Act since the end of the fiscal year covered by the
         document referred to in (1) above.

                  (3) The description of the Common Stock, par value $.10 per
         share ("Common Stock"), contained in a registration statement filed
         under the Exchange Act, including any amendment or report filed for the
         purpose of updating such description.

         All documents subsequently filed by the Registrant pursuant to Sections
 13(a), 13(c), 14, and 15(d) of the Exchange Act, prior to the filing of a
 post-effective amendment which indicates that all shares of Common Stock
 offered hereby have been sold or which deregisters all shares of Common Stock
 then remaining unsold, shall be deemed to be incorporated by reference herein
 and to be part hereof from

                                        2

<PAGE>

the date of the filing of such documents.

         Item 4. Description of Securities.
                 --------------------------

         Not applicable.

         Item 5. Interests of Named Experts and Counsel.
                 ---------------------------------------

         Not applicable.

         Item 6. Indemnification of Directors and Officers.
                 ------------------------------------------

         Section 145 of the Delaware General Corporation Law provides that a
 corporation may indemnify any person who was or is a party or is threatened to
 be made a party to any threatened, pending or completed action or proceeding,
 whether civil, criminal, administrative or investigative, by reason of the fact
 that he is or was a director, officer, employee or agent of the corporation or
 is or was serving at its request in such capacity in another corporation or
 business association, against expenses (including attorneys' fees), judgments,
 fines and amounts paid in settlement actually and reasonably incurred by him in
 connection with such action, suit or proceeding if he acted in good faith and
 in a manner he reasonably believed to be in or not opposed to the best
 interests of the corporation, and, with respect to any criminal action or
 proceeding, had no reasonable cause to believe his conduct was unlawful.

         Section 102(b)(7) of the Delaware General Corporation Law permits a
 corporation to provide in its certificate of incorporation that a director of
 the corporation shall not be personally liable to the corporation or its
 stockholders for monetary damages for breach of fiduciary duty as a director,
 except for liability (i) for any breach of the director's duty of loyalty to
 the corporation or its stockholders, (ii) for acts or omissions not in good
 faith or which involve intentional misconduct or a knowing violation of law,
 (iii) under Section 174 of the Delaware General Corporation Law, or (iv) for
 any transaction from which the director derived an improper personal benefit.

         Article NINTH of the Registrant's Restated Certificate of Incorporation
 (as amended, the "Certificate of Incorporation") provides that no director of
 the Registrant shall be liable for any breach of a fiduciary duty, except to
 the extent that the Delaware General Corporation Law prohibits the elimination
 or limitation of liability of directors for breach of fiduciary duty.

         Article THIRTEENTH of the Certificate of Incorporation provides that a
 director or officer of the Registrant (a) shall be indemnified by the
 Registrant against all costs, charges, expenses (including attorneys' fees),
 judgments, fines and amounts

                                        3

<PAGE>

 paid in settlement incurred in connection with any litigation or other legal
 proceeding (other than an action by or in the right of the Registrant) brought
 against him by virtue of his position as a director or officer of the
 Registrant if he acted in good faith and in a manner he reasonably believed to
 be in, or not opposed to, the best interests of the Registrant, and, with
 respect to any criminal action or proceeding, has no reasonable cause to
 believe his conduct was unlawful and (b) shall be indemnified by the Registrant
 against all costs, charges and expenses (including attorneys' fees) incurred in
 connection with any action by or in the right of the Registrant brought against
 him by virtue of his position as a director or officer of the Registrant if he
 acted in good faith and in a manner he reasonably believed to be in, or not
 opposed to, the best interests of the Registrant, except that no
 indemnification shall be made with respect to any such matter as to which such
 person shall have been adjudged to be liable to the Registrant, unless a court
 determines that, despite such adjudication but in view of all of the
 circumstances, he is entitled to indemnification of such expenses.
 Notwithstanding the foregoing, to the extent that a director or officer has
 been successful, on the merits or otherwise, including, without limitation, the
 dismissal of an action without prejudice or the settlement of an action without
 admission of liability, he is required to be indemnified by the Registrant
 against all costs, charges and expenses (including attorneys' fees) incurred in
 connection therewith. Expenses shall be advanced to a director or officer at
 his request, provided that he undertakes to repay the amount advanced if it is
 ultimately determined that he is not entitled to indemnification for such
 expenses.

         Indemnification is required to be made unless the Board of Directors or
 independent legal counsel determines that the applicable standard of conduct
 required for indemnification has not been met. In the event of a determination
 by the Board of Directors or independent legal counsel that the director or
 officer did not meet the applicable standard of conduct required for
 indemnification, or if the Registrant fails to make the applicable standard of
 conduct required for indemnification, or if the Registrant fails to make an
 indemnification payment within 60 days after such payment is claimed by such
 person, such person is permitted to petition the court to make an independent
 determination as to whether such person is entitled to indemnification. As a
 condition precedent to the right of indemnification, the director or officer
 must give the Registrant notice of the action for which indemnity is sought and
 the Registrant has the right to participate in such action or assume the
 defense thereto.

         Article THIRTEENTH of the Certificate of Incorporation further provides
 that the indemnification provided therein is not exclusive, and provides that
 in the event that the Delaware General Corporation Law is amended to expand the
 indemnification permitted to directors or officers the Registrant must
 indemnify those persons to the fullest extent permitted by such law as so
 amended.


                                        4

<PAGE>

         Item 7. Exemption from Registration Claimed.
                 ------------------------------------

         Not applicable.

         Item 8. Exhibits.
                 ---------

         The Exhibit Index immediately preceding the exhibits is incorporated
 herein by reference.

         Item 9. Undertakings.
                 -------------

         1.       The Registrant hereby undertakes:

                  (a) To file, during any period in which offers or sales are
         being made, a post-effective amendment to this Registration Statement:

                           (i) To include any prospectus required by
         Section 10(a)(3) of the Securities Act;

                           (ii) To reflect in the prospectus any facts or events
         arising after the effective date of the Registration Statement (or the
         most recent post-effective amendment thereof) which, individually or in
         the aggregate, represent a fundamental change in the information set
         forth in the Registration Statement. Notwithstanding the foregoing, any
         increase or decrease in volume of securities offered (if the total
         dollar value of securities offered would not exceed that which was
         registered) and any deviation from the low or high end of the estimated
         maximum offering range may be reflected in the form of prospectus filed
         with the Commission pursuant to Rule 424(b) if, in the aggregate, the
         changes in volume and price represent no more than 20% change in the
         maximum aggregate offering price set forth in the "Calculation of
         Registration Fee" table in the effective Registration Statement; and

                           (iii) To include any material information with
         respect to the plan of distribution not previously disclosed in the
         Registration Statement or any material change to such information in
         the Registration Statement;

         PROVIDED, HOWEVER, that paragraphs (i) and (ii) do not apply if the
         Registration Statement is on Form S-3 or Form S-8, and the information
         required to be included in a post-effective amendment by those
         paragraphs is contained in periodic reports filed by the Registrant
         pursuant to Section 13 or Section 15(d) of the Exchange Act that are
         incorporated by reference in the Registration Statement.



                                        5

<PAGE>

                  (b) That, for the purpose of determining any liability under
         the Securities Act, each such post-effective amendment shall be deemed
         to be a new Registration Statement relating to the securities offered
         therein, and the offering of such securities at that time shall be
         deemed to be the initial bona fide offering thereof.

                  (c) To remove from registration by means of a post-effective
         amendment any of the securities being registered which remain unsold at
         the termination of the offering.

         2. The Registrant hereby undertakes that, for the purposes of
determining any liability under the Securities Act, each filing of the
Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange Act (and, where applicable, each filing of an employee benefit plan's
annual report pursuant to Section 15(d) of the Exchange Act) that is
incorporated by reference in the Registration Statement shall be deemed to be a
new Registration Statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be in the initial
bona fide offering thereof.

         3. Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons
of the Registrant pursuant to the foregoing provisions, or otherwise, the
Registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the
Securities Act and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question of whether such
indemnification by it is against public policy as expressed in the Securities
Act and will be governed by the final adjudication of such issue.


                                        6

<PAGE>

                                   SIGNATURES

         Pursuant to the requirements of the Securities Act, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the town of Marlborough, Commonwealth of Massachusetts, on the
6th day of July, 1998.

                                                SEPRACOR INC.


                                                By: /s/ Timothy J. Barberich
                                                    ----------------------------
                                                    Timothy J. Barberich,
                                                    President and
                                                    Chief Executive Officer



                                POWER OF ATTORNEY

         We, the undersigned officers and directors of Sepracor Inc. hereby
severally constitute Timothy J. Barberich, David P. Southwell and Mark G.
Borden, Esq., and each of them singly, our true and lawful attorneys with full
power to them, and each of them singly, to sign for us and in our names in the
capacities indicated below, the Registration Statement on Form S-8 filed
herewith and any and all subsequent amendments to said Registration Statement,
and generally to do all such things in our names and behalf in our capacities as
officers and directors to enable Sepracor Inc. to comply with all requirements
of the Securities and Exchange Commission, hereby ratifying and confirming our
signatures as they may be signed by said attorneys, or any of them, to said
Registration Statement and any and all amendments thereto.


                                        7

<PAGE>



         Pursuant to the requirements of the Securities Act, this Registration
Statement has been signed below by the following persons in the capacities and
on the date indicated.

<TABLE>
<CAPTION>

Signature                                     Title                                   Date
- ---------                                     -----                                   ----

<S>                                           <C>                                     <C>
/s/ Timothy J. Barberich                      President; Chief Executive              July 6, 1998
- ----------------------------                  Officer and Director
Timothy J. Barberich                          (Principal Executive
                                              Officer)
                                              

/s/ David P. Southwell                        Executive Vice President;               July 6, 1998
- ----------------------------                  Chief Financial Officer
David P. Southwell                            (Principal Financial Officer)
                                              

/s/ Robert F. Scumaci                         Senior Vice President,                  July 6, 1998
- ----------------------------                  Finance and Administration
Robert F. Scumaci                             (Principal Accounting
                                              Officer)
                                              

/s/ James G. Andress                          Director                                July 6, 1998
- ----------------------------
James G. Andress

/s/ Digby W. Barrios                          Director                                July 6, 1998
- ----------------------------
Digby W. Barrios

/s/ Robert J. Cresci                          Director                                July 6, 1998
- ----------------------------
Robert J. Cresci

/s/ Robert F. Johnston                        Director                                July 6, 1998
- ----------------------------
Robert F. Johnston


                                        8

<PAGE>


<S>                                           <C>                                     <C>
/s/ Keith Mansford, Ph.D.                     Director                                July 6, 1998
- ----------------------------
Keith Mansford, Ph.D.

/s/ James F. Mrazek                           Director                                July 6, 1998
- ----------------------------
James F. Mrazek

/s/ Alan A. Steigrod                          Director                                July 6, 1998
- ----------------------------
Alan A. Steigrod
</TABLE>



                                        9

<PAGE>


                                  Exhibit Index
                                  -------------

<TABLE>
<CAPTION>
Exhibit
Number          Description
- ------          -----------
<S>             <C>
 4.1            Certificate of Incorporation of the Registrant, as amended
 4.2(1)         By-Laws of the Registrant
 4.3(1)         Specimen Certificate of Common Stock of the Registrant
 5              Opinion of Hale and Dorr LLP
23.1            Consent of Hale and Dorr LLP (included in Exhibit 5)
23.2            Consent of PricewaterhouseCoopers LLP
23.3            Consent of Arthur Andersen LLP
24              Power of Attorney (included in the signature pages of this
                Registration Statement)
</TABLE>





- ------------------
(1) Incorporated herein by reference from the Registrant's Registration
    Statement on Form S-1 (File No. 33-41653).



                                                                     Exhibit 4.1
                                                                     -----------

                      RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                                  SEPRACOR INC.


     Victor H. Woolley and Mark G. Borden, being the duly elected Vice
President, Finance and Secretary, respectively, of Sepracor Inc., a corporation
organized and existing under and by virtue of the laws of the State of Delaware,
do hereby certify as follows:

     1. The name of the corporation is Sepracor Inc. (hereinafter called the
"Corporation").

     The date of filing of its original Certificate of incorporation with the
Secretary of State was January 27, 1984.

     2. That by vote of the Board of Directors of the Corporation at a meeting
held on October 29, 1991, and in accordance with Section 245 of the General
Corporation Law of Delaware, the Board of Directors adopted a resolution setting
forth the proposed Restated Certificate of Incorporation of the Corporation.

     3. This Restated Certificate of Incorporation only restates and integrates
and does not further amend the Corporation's Restated Certificate of
Incorporation and there is no discrepancy between such provisions and the
provisions of this Restated Certificate of Incorporation.

          FIRST: The name of the corporation is Sepracor Inc. (hereinafter
called the "Corporation").

          SECOND: The registered office of the Corporation is Corporation Trust
Center, 1209 Orange Street, in the City of Wilmington, in the County of New
Castle, in the State of Delaware. The name of its registered agent at that
address is The Corporation Trust Company.

          THIRD: The purpose of the Corporation is to engage in any lawful act
or activity for which corporations may be organized under the General
Corporation Law of Delaware.

          FOURTH: The aggregate number of shares which the Corporation shall
have authority to issue is 26,000,000 of which (i) 25,000,000 shares shall be
Common Stock, $0.10 par value per share ("Common Stock"), and (ii) 1,000,000
shares shall be Preferred Stock, $1.00 par value per share ("Preferred Stock").


<PAGE>




               A. PREFERRED STOCK

               Preferred Stock may be issued from time to time in one or more
series, each of such series to have such terms as stated or expressed herein and
in the resolution or resolutions providing for the issue of such series adopted
by the Board of Directors of the Corporation as hereinafter provided. Any shares
of Preferred Stock which may be redeemed, purchased or acquired by the
Corporation may be reissued except as otherwise provided by law. Different
series of Preferred Stock shall not be construed to constitute different classes
of shares for the purposes of voting by classes unless expressly provided.

               Authority is hereby expressly granted to the Board of Directors
from time to time to issue the Preferred Stock in one or more series, and in
connection with the creation of any such series, by resolution or resolutions
providing for the issue of the shares thereof, to determine and fix such voting
powers, full or limited, or no voting powers, and such designations, preferences
and relative participating, optional or other special rights, and
qualifications, limitations or restrictions thereof, including without
limitation thereof, dividend rights, conversion rights, redemption privileges
and liquidation preferences, as shall be stated and expressed in such
resolutions, all to the full extent now or hereafter permitted by the General
Corporation Law of Delaware. Without limiting the generality of the foregoing,
the resolutions providing for issuance of any series of Preferred Stock may
provide that such series shall be superior or rank equally or be junior to the
Preferred Stock of any other series to the extent permitted by law. Except as
otherwise provided in this Restated Certificate of Incorporation, no vote of the
holders of the Preferred Stock or Common Stock shall be a prerequisite to the
designation or issuance of any shares of any series of the Preferred Stock
authorized by and complying with the conditions of this Restated Certificate of
Incorporation, the right to have such vote being expressly waived by all present
and future holders of the capital stock of the Corporation."

               B. COMMON STOCK.

                    1.   General. The voting, dividend and liquidation rights of
                         the holders of the Common Stock are subject to and
                         qualified by the rights of the holders of the Preferred
                         Stock.

                    2.   Voting. The holders of the Common stock are entitled to
                         one vote for each share held at all meetings of
                         stockholders (and written actions in lieu of meetings).
                         There shall be no cumulative voting.




<PAGE>



                    3.   Dividends. Dividends may be declared and paid on the
                         Common Stock from funds lawfully available therefor as
                         and when determined by the Board of Directors and
                         subject to any preferential dividend rights of any then
                         outstanding Preferred Stock.

                    4.   Liquidation. Upon the dissolution or liquidation of the
                         Corporation, whether voluntary or involuntary, holders
                         of Common Stock will be entitled to receive all assets
                         of the Corporation available for distribution to its
                         stockholders, subject to any preferential rights of any
                         then outstanding Preferred Stock.

          FIFTH: To the fullest extent permitted by the Delaware General
Corporation Law, as it exists or may be amended, a director of the Corporation
shall be not liable to the Corporation or its stockholders for monetary damages
for breach of fiduciary duty as a director.

          SIXTH: The election of directors need not be by written ballot unless
the by-laws so provide.

          SEVENTH: The Board of Directors of the Corporation is authorized and
empowered from time to time in its discretion to make, alter, amend or repeal
by-laws of the Corporation, except as such power may be restricted or limited by
the General Corporation Law of the State of Delaware.

          EIGHTH: Whenever any compromise or arrangement is proposed between
this Corporation and its creditors or any class of them and/or between this
Corporation and its stockholders or any class of them, any court of equitable
jurisdiction within the State of Delaware may, on the application in a summary
way of this Corporation or of any creditor or stockholder thereof or on the
application of any receiver or receivers appointed for this Corporation under
the provisions of Section 291 of Title 8 of the Delaware Code or on the
application of trustees in dissolution or of any receiver or receivers appointed
for this Corporation under the provisions of Section 279 of Title 8 of the
Delaware Code order a meeting of the creditors or class of creditors, and/or of
the stockholders or class of stockholders of this Corporation, as the case may
be, to be summoned in such manner as the said court directs. If a majority in
number representing three-fourths in value of the creditors or class of
creditors, and/or of the stockholders or class of stockholders of this
Corporation, as the case may be, agrees to any compromise or arrangement and to
any reorganization of this Corporation as consequence of such compromise or
arrangement, the said compromise or arrangement and the said reorganization
shall, if sanctioned by the court to which the said application has been made,
be binding on all the creditors or class of creditors, and/or on all the
stockholders or class of stockholders of this Corporation, as the case may be,
and also on this Corporation.


<PAGE>



          NINTH: The Corporation reserves the right to amend, alter, change or
repeal any provision contained in this Certificate of Incorporation in the
manner now or hereafter prescribed by law, and all rights and powers conferred
herein on stockholders, directors and officers are subject to this reserved
power.

          TENTH: This Article is inserted for the management of the business and
for the conduct of the affairs of the Corporation, and it is expressly provided
that it is intended to be in furtherance and not in limitation or exclusion of
the powers conferred by the statutes of the State of Delaware.

               1. Number of Directors. The number of directors which shall
constitute the whole Board of Directors shall be determined by resolution of a
majority of the Board of Directors, but in no event shall be less than three.
The number of directors may be decreased at any time and from time to time by a
majority of the directors then in office, but only to eliminate vacancies
existing by reason of the death, resignation, removal or expiration of the term
of one or more directors. The directors shall be elected at the annual meeting
of stockholders by such stockholders as have the right to vote on such election.
Directors need not be stockholders of the Corporation.

               2. Classes of Directors. The Board of Directors shall be and is
divided into three classes: Class I, Class II and Class III. No one class shall
have more than one director more than any other class. If a fraction is
contained in the quotient arrived at by dividing the authorized number of
directors by three, then, if such fraction is one-third, the extra director
shall be a member of the Class I and, if such fraction is two-thirds, one of the
extra directors shall be a member of Class I and the other extra director shall
be a member of Class II, unless otherwise provided for from time to time by
resolution adopted by a majority of the Board of Directors.

               3. Election of Directors. Elections of directors need not be by
written ballot except as and to the extent provided in the By-laws of the
Corporation.

               4. Terms of Office. Each director shall serve for a term ending
on the date of the third annual meeting following the annual meeting at which
such director was elected; provided, however, that each initial director in
Class I shall serve for a term ending on the date of the annual meeting next
following the end of the Corporation's fiscal year ending December 31, 1993;
each initial director in Class II shall serve for a term ending on the date of
the annual meeting next following the end of the Corporation's fiscal year
ending December 31, 1992; and each initial director in Class III shall serve for
a term ending on the date of the annual meeting next following the end of the
Corporation's fiscal year ending December 31, 1991.

               5. Allocation of Directors Among Classes in the Event of
Increases or Decreases in the Number of Directors. In the event of any increase
or decrease in the authorized number of directors, (i) each director then
serving as such


<PAGE>



shall nevertheless continue as a director of the class of which he is a member
until the expiration of his current term or his prior death, retirement or
resignation and (ii) the newly created or eliminated directorships resulting
from such increase or decrease shall be apportioned by the Board of Directors
among the three classes of directors so as to ensure that no one class has more
than one director more than any other class. To the extent possible, consistent
with the foregoing rule, any newly created directorships shall be added to those
classes whose terms of office are to expire at the latest dates following such
allocation, and any newly eliminated directorships shall be subtracted from
those classes whose terms of office are to expire at the earliest dates
following such allocation, unless otherwise provided for from time to time by
resolution adopted by a majority of the directors then in office, although less
than a quorum.

               6. Tenure. Notwithstanding any provisions to the contrary
contained herein, each director shall hold office until his successor is elected
and qualified, or until his earlier death, resignation or removal.

               7. Vacancies. Any vacancy in the Board of Directors, however
occurring, including a vacancy resulting from an enlargement of the Board, may
be filled only by vote of a majority of the directors then in office, although
less than a quorum, or by a sole remaining director. A director elected to fill
a vacancy shall be elected for the unexpired term of his predecessor in office,
if applicable, and a director chosen to fill a position resulting from an
increase in the number of directors shall hold office until the next election of
the class for which such director shall have been chosen and until his successor
is elected and qualified, or until his earlier death, resignation or removal.

               8. Quorum. A majority of the total number of the whole Board of
Directors shall constitute a quorum at all meetings of the Board of Directors.
In the event one or more of the directors shall be disqualified to vote at any
meeting, then the required quorum shall be reduced by one for each such director
so disqualified; provided, however, that in no case shall less than one-third
(1/3) of the number so fixed constitute a quorum. In the absence of a quorum at
any such meeting, a majority of the directors present may adjourn the meeting
from time to time without further notice other than announcement at the meeting,
until a quorum shall be present.

               9. Action at Meeting. At any meeting of the Board of Directors at
which a quorum is present, the vote of a majority of those present shall be
sufficient to take any action, unless a different vote is specified by law or
the Corporation's Restated Certificate of Incorporation or By-Laws.

               10. Removal. Any one or more or all of the directors may be
removed, with or without cause, by the holders of at least seventy-five percent
(75%) of the shares then entitled to vote at an election of directors.



<PAGE>



               11. Stockholder Nominations and Introduction of Business, Etc.
Advance notice of stockholder nominations for election of directors and other
business to be brought by stockholders before a meeting of stockholders shall be
given in the manner provided in the By-Laws of the Corporation.

               12. Amendments to Article. Notwithstanding any other provisions
of law, this Restated Certificate of Incorporation or the Corporation's Amended
and Restated By-Laws, and notwithstanding the fact that a lesser percentage may
be specified by law, the affirmative vote of the holders of at least
seventy-five percent (75%) of the votes which all the stockholders would be
entitled to cast at any annual election of directors or class of directors shall
be required to amend or repeal, or to adopt any provision inconsistent with,
this Article TENTH."

          ELEVENTH: Until the closing of a firm commitment, underwritten public
offering of the Corporation's Common Stock (a "Public Offering"), any action
required or permitted to be taken at any annual or special meeting of
stockholders of the Corporation may be taken without a meeting, without prior
notice and without a vote, if a consent in writing, setting forth the action so
taken, is signed by the holders of outstanding stock having not less than the
minimum number of votes that would be necessary to authorize or take such action
at a meeting at which all shares entitled to vote on such action were present
and voted. Prompt notice of the taking of corporate action without a meeting by
less than unanimous written consent shall be given to those stockholders who
have not consented in writing. Effective upon the closing of a Public Offering,
stockholders of the Corporation may not take any action by written consent in
lieu of a meeting. Notwithstanding any other provision of law, this Restated
Certificate of Incorporation or the Corporation's By-laws, as amended, and
notwithstanding the fact that a lesser percentage may be specified by law, the
affirmative vote of the holders of at least seventy-five percent (75%) of the
votes which all the stockholders would be entitled to cast at any annual
election of directors or class of directors shall be required to amend or
repeal, or to adopt any provision inconsistent with this Article ELEVENTH.

          TWELFTH: Special meetings of stockholders may be called at any time by
the President or by the Chairman of the Board of Directors. Business transacted
at any special meeting of stockholders shall be limited to matters relating to
the purpose or purposes stated in the notice of meeting. Notwithstanding any
other provision of law, this Restated Certificate of Incorporation or the
Corporation's Amended and Restated By-laws, and notwithstanding the fact that a
lesser percentage may be specified by law, the affirmative vote of the holders
of at least seventy-five percent (75%) of the votes which all stockholders would
be entitled to cast at any annual election of directors or class of directors
shall be required to amend or repeal, or to adopt any provision inconsistent
with this Article TWELFTH."




<PAGE>



          THIRTEENTH:

               1. Actions, Suits and Proceedings Other than by or in the Right
of the Corporation. The Corporation shall indemnify each person who was or is a
party or is threatened to be made a party to any threatened, pending or
completed action, suit or proceeding, whether civil, criminal, administrative or
investigative (other than an action by or in the right of the Corporation), by
reason of the fact that he is or was, or has agreed to become, a director or
officer of the Corporation, or is or was serving, or has agreed to serve, at the
request of the Corporation, as a director, officer or trustee of, or in a
similar capacity with, another corporation, partnership, joint venture, trust or
other enterprise (including any employee benefit plan) (all such persons being
referred to hereafter as an "Indemnitee"), or by reason of any action alleged to
have been taken or omitted in such capacity, against all expenses (including
attorneys' fees), judgments, fines and amounts paid in settlement actually and
reasonably incurred by him or on his behalf in connection with such action, suit
or proceeding and any appeal therefrom, if he acted in good faith and in a
manner he reasonably believed to be in, or not opposed to, the best interests of
the Corporation, and, with respect to any criminal action or proceeding, had no
reasonable cause to believe his conduct was unlawful. The termination of any
action, suit or proceeding by judgment, order, settlement, conviction or upon a
plea of nolo contendere or its equivalent, shall not, of itself, create a
presumption that the person did not act in good faith and in a manner which he
reasonably believed to be in, or not opposed to, the best interests of the
Corporation, and, with respect to any criminal action or proceeding, had
reasonable cause to believe that his conduct was unlawful. Notwithstanding
anything to the contrary in this Article, except as set forth in Section 6
below, the Corporation shall not indemnify an Indemnitee seeking indemnification
in connection with a proceeding (or part thereof) initiated by the Indemnitee
unless the initiation thereof was approved by the Board of Directors of the
Corporation.

               2. Actions or Suits by or in the Right of the Corporation. The
Corporation shall indemnify any Indemnitee who was or is a party or is
threatened to be made a party to any threatened, pending or completed action or
suit by or in the right of the Corporation to procure a judgment in its favor by
reason of the fact that he is or was, or has agreed to become, a director or
officer of the Corporation, or is or was serving, or has agreed to serve, at the
request of the Corporation, as a director, officer or trustee of, or in a
similar capacity with, another corporation, partnership, joint venture, trust or
other enterprise (including any employee benefit plan), or by reason of any
action alleged to have been taken or omitted in such capacity, against all
expenses (including attorneys' fees) and amounts paid in settlement actually and
reasonably incurred by him or on his behalf in connection with such action, suit
or proceeding and any appeal therefrom, if he acted in good faith and in a
manner he reasonably believed to be in, or not opposed to, the best interests of
the Corporation, except that no indemnification shall be made in respect of any
claim, issue or matter as to which such person shall have been adjudged to be
liable to the Corporation unless and only to the extent that the Court of
Chancery of


<PAGE>



Delaware or the court in which such action or suit was brought shall determine
upon application that, despite the adjudication of such liability but in view of
all the circumstances of the case, such person is fairly and reasonably entitled
to indemnity for such expenses (including attorneys' fees) which the Court of
Chancery of Delaware or such other court shall deem proper.

               3. Indemnification for Expenses of Successful Party.
Notwithstanding the other provisions of this Article, to the extent that an
Indemnitee has been successful, on the merits or otherwise, in defense of any
action, suit or proceeding referred to in Sections 1 and 2 of this Article, or
in defense of any claim, issue or matter therein, or on appeal from any such
action, suit or proceeding, he shall be indemnified against all expenses
(including attorneys' fees) actually and reasonably incurred by him or on his
behalf in connection therewith. Without limiting the foregoing, if any action,
suit or proceeding is disposed of, on the merits or otherwise (including a
disposition without prejudice), without (i) the disposition being adverse to the
Indemnitee, (ii) an adjudication that the Indemnitee was liable to the
Corporation, (iii) a plea of guilty or nolo contendere by the Indemnitee, (iv)
an adjudication that the Indemnitee did not act in good faith and in a manner he
reasonably believed to be in or not opposed to the best interests of the
Corporation, and (v) with respect to any criminal proceeding, an adjudication
that the Indemnitee had reasonable cause to believe his conduct was unlawful,
the Indemnitee shall be considered for the purposes hereof to have been wholly
successful with respect thereto.

               4. Notification and Defense of Claim. As a condition precedent to
his right to be indemnified, the Indemnitee must notify the Corporation in
writing as soon as practicable of any action, suit, proceeding or investigation
involving him for which indemnity will or could be sought. With respect to any
action, suit, proceeding or investigation of which the Corporation is so
notified, the Corporation will be entitled to participate therein at its own
expense and/or to assume the defense thereof at its own expense, with legal
counsel reasonably acceptable to the Indemnitee. After notice from the
Corporation to the Indemnitee of its election so to assume such defense, the
Corporation shall not be liable to the Indemnitee for any legal or other
expenses subsequently incurred by the Indemnitee in connection with such claim,
other than as provided below in this Section 4. The Indemnitee shall have the
right to employ his own counsel in connection with such claim, but the fees and
expenses of such counsel incurred after notice from the Corporation of its
assumption of the defense thereof shall be at the expense of the Indemnitee
unless (i) the employment of counsel by the Indemnitee has been authorized by
the Corporation, (ii) counsel to the Indemnitee shall have reasonably concluded
that there may be a conflict of interest or position on any significant issue
between the Corporation and the Indemnitee in the conduct of the defense of such
action or (iii) the Corporation shall not in fact have employed counsel to
assume the defense of such action, in each of which cases the fees and expenses
of counsel for the Indemnitee shall be at the expense of the Corporation, except
as otherwise expressly provided by this Article. The Corporation shall not be
entitled, without the


<PAGE>



consent of the Indemnitee, to assume the defense of any claim brought by or in
the right of the Corporation or as to which counsel for the Indemnitee shall
have reasonably made the conclusion provided for in clause (ii) above.

               5. Advance of Expenses. Subject to the provisions of Section 6
below, in the event that the Corporation does not assume the defense pursuant to
Section 4 of this Article of any action, suit, proceeding or investigation of
which the Corporation receives notice under this Article, any expenses
(including attorneys' fees) incurred by an Indemnitee in defending a civil or
criminal action, suit, proceeding or investigation or any appeal therefrom shall
be paid by the Corporation in advance of the final disposition of such matter,
provided, however, that the payment of such expenses incurred by an Indemnitee
in advance of the final disposition of such matter shall be made only upon
receipt of an undertaking by or on behalf of the Indemnitee to repay all amounts
so advanced in the event that it shall ultimately be determined that the
Indemnitee is not entitled to be indemnified by the Corporation as authorized in
this Article. Such undertaking may be accepted without reference to the
financial ability of such person to make such repayment.

               6. Procedure for Indemnification. In order to obtain
indemnification or advancement of expenses pursuant to Section 1, 2, 3 or 5 of
this Article, the Indemnitee shall submit to the Corporation a written request,
including in such request such documentation and information as is reasonably
available to the Indemnitee and is reasonably necessary to determine whether and
to what extent the Indemnitee is entitled to indemnification or advancement of
expenses. Any such indemnification or advancement of expenses shall be made
promptly, and in any event within 60 days after receipt by the Corporation of
the written request of the Indemnitee, unless with respect to requests under
Section 1, 2 or 5 the Corporation determines, by clear and convincing evidence,
within such 60-day period that the Indemnitee did not meet the applicable
standard of conduct set forth in Section 1 or 2, as the case may be. Such
determination shall be made in each instance by (a) a majority vote of a quorum
of the directors of the Corporation consisting of persons who are not at that
time parties to the action, suit or proceeding in question ("disinterested
directors"), (b) if no such quorum is obtainable, a majority vote of a committee
of two or more disinterested directors, (c) a majority vote of a quorum of the
outstanding shares of stock of all classes entitled to vote for directors,
voting as a single class, which quorum shall consist of stockholders who are not
at that time parties to the action, suit or proceeding in question, (d)
independent legal counsel (who may be regular legal counsel to the Corporation),
or (e) a court of competent jurisdiction.

               7. Remedies. The right to indemnification or advances as granted
by this Article shall be enforceable by the Indemnitee in any court of competent
jurisdiction if the Corporation denies such request, in whole or in part, or if
no disposition thereof is made within the 60-day period referred to above in
Section 6. Unless otherwise provided by law, the burden of proving that the
Indemnitee is not entitled to indemnification or advancement of expenses under
this


<PAGE>



Article shall be on the Corporation. Neither the failure of the Corporation to
have made a determination prior to the commencement of such action that
indemnification is proper in the circumstances because the Indemnitee has met
the applicable standard of conduct, nor an actual determination by the
Corporation pursuant to Section 6 that the Indemnitee has not met such
applicable standard of conduct, shall be a defense to the action or create a
presumption that the Indemnitee has not met the applicable standard of conduct.
The Indemnitee's expenses (including attorneys' fees) incurred in connection
with successfully establishing his right to indemnification, in whole or in
part, in any such proceeding shall also be indemnified by the Corporation.

               8. Subsequent Amendment. No amendment, termination or repeal of
this Article or of the relevant provisions of the General Corporation Law of
Delaware or any other applicable laws shall affect or diminish in any way the
rights of any Indemnitee to indemnification under the provisions hereof with
respect to any action, suit, proceeding or investigation arising out of or
relating to any actions, transactions or facts occurring prior to the final
adoption of such amendment, termination or repeal.

               9. Other Rights. The indemnification and advancement of expenses
provided by this Article shall not be deemed exclusive of any other rights to
which an Indemnitee seeking indemnification or advancement of expenses may be
entitled under any law (common or statutory), agreement or vote of stockholders
or disinterested directors or otherwise, both as to action in his official
capacity and as to action in any other capacity while holding office for the
Corporation, and shall continue as to an Indemnitee who has ceased to be a
director or officer, and shall inure to the benefit of the estate, heirs,
executors and administrators of the Indemnitee. Nothing contained in this
Article shall be deemed to prohibit, and the Corporation is specifically
authorized to enter into, agreements with officers and directors providing
indemnification rights and procedures different from those set forth in this
Article. In addition, the Corporation may, to the extent authorized from time to
time by its Board of Directors, grant indemnification rights to other employees
or agents of the Corporation or other persons serving the Corporation and such
rights may be equivalent to, or greater or less than, those set forth in this
Article.

               10. Partial Indemnification. If an Indemnitee is entitled under
any provision of this Article to indemnification by the Corporation for some or
a portion of the expenses (including attorneys' fees), judgments, fines or
amounts paid in settlement actually and reasonably incurred by him or on his
behalf in connection with any action, suit, proceeding or investigation and any
appeal therefrom but not, however, for the total amount thereof, the Corporation
shall nevertheless indemnify the Indemnitee for the portion of such expenses
(including attorneys' fees), judgments, fines or amounts paid in settlement to
which the Indemnitee is entitled.



<PAGE>



               11. Insurance. The Corporation may purchase and maintain
insurance, at its expense, to protect itself and any director, officer, employee
or agent of the Corporation or another corporation, partnership, joint venture,
trust or other enterprise (including any employee benefit plan) against any
expense, liability or loss incurred by him in any such capacity, or arising out
of his status as such, whether or not the Corporation would have the power to
indemnify such person against such expense, liability or loss under the General
Corporation Law of Delaware.

               12. Merger or Consolidation. If the Corporation is merged into or
consolidated with another corporation and the Corporation is not the surviving
corporation, the surviving corporation shall assume the obligations of the
Corporation under this Article with respect to any action, suit, proceeding or
investigation arising out of or relating to any actions, transactions or facts
occurring prior to the date of such merger or consolidation.

               13. Savings Clause. If this Article or any portion hereof shall
be invalidated on any ground by any court of competent jurisdiction, then the
Corporation shall nevertheless indemnify each Indemnitee as to any expenses
(including attorneys' fees), judgments, fines and amounts paid in settlement in
connection with any action, suit, proceeding or investigation, whether civil,
criminal or administrative, including an action by or in the right of the
Corporation, to the fullest extent permitted by any applicable portion of this
Article that shall not have been invalidated and to the fullest extent permitted
by applicable law.

               14. Definitions. Terms used herein and defined in Section 145(h)
and Section 145(i) of the General Corporation Law of Delaware shall have the
respective meanings assigned to such terms in such Section 145(h) and Section
145(i).

               15. Subsequent Legislation. If the General Corporation Law of
Delaware is amended after adoption of this Article to expand further the
indemnification permitted to Indemnitees, then the Corporation shall indemnify
such persons to the fullest extent permitted by the General Corporation Law of
Delaware, as so amended.

     This Restated Certificate of Incorporation supersedes and takes the place
of the heretofore existing Restated Certificate of Incorporation of this
Corporation and any and all amendments, certificates and supplements thereto, if
any.




<PAGE>



     IN WITNESS WHEREOF, said Sepracor Inc. has caused this Restated Certificate
of Incorporation to be signed by Victor H. Woolley, its Vice President, Finance,
and attested by Mark G. Borden, its Secretary, this 17th day of December, 1991.

                                   By: /s/ Victor H. Woolley
                                      -------------------------
                                       Victor H. Woolley
                                       Vice President, Finance





ATTEST:



/s/ Mark G. Borden
- ---------------------------
Mark G. Borden, Secretary




<PAGE>



                       CERTIFICATE OF OWNERSHIP AND MERGER

                                     merging

                              IBF Biotechnics Inc.,
                             a Delaware corporation

                                      into

                                 Sepracor Inc.,
                             a Delaware corporation


     Sepracor Inc., a corporation organized and existing under the laws of the
State of Delaware (the "Corporation"), does hereby certify:

     FIRST: That the Corporation was incorporated on the 27th day of January,
1984, pursuant to the General Corporation Law of the State of Delaware.

     SECOND: That the Corporation owns all of the outstanding shares of the only
class of authorized capital stock of IBF Biotechnics Inc., a corporation
incorporated on December 8, 1986, pursuant to the General Corporation Law of the
State of Delaware.

     THIRD: That the Corporation, by the following resolutions of its Board of
Directors, duly adopted at a Meeting of the Board of Directors on November 24,
1992, determined to merge IBF Biotechnics Inc. into the Corporation:

RESOLVED: That the Corporation, being the holder of 100% of the authorized
          and outstanding capital stock of IBF Biotechnics Inc., a Delaware
          corporation ("IBF"), hereby approves and authorizes the merger of IBF
          with and into the Company (the "IBF Merger") pursuant to Section 253
          of the Delaware General Corporation Law, such merger to be effective
          upon the filing of a Certificate of Ownership and Merger with the
          Secretary of State of Delaware, and that the Company hereby assumes
          all of the obligations of IBF which the Company is required to assume
          under Delaware law.



<PAGE>



FURTHER 
RESOLVED: That the Restated Certificate of Incorporation of the Company, as
          amended, shall be the Certificate of Incorporation of the Company as
          of the effective date of the IBF Merger.

FURTHER
RESOLVED: That the appropriate officers of the Company be, and each of them
          acting singly hereby is, authorized to execute all such documents and
          instruments as they or any of them deem necessary or appropriate to
          effectuate the purposes of the foregoing resolutions.

     IN WITNESS WHEREOF, Sepracor Inc. has caused this Certificate to be signed
by its President and attested by its Secretary, this 21st day of December, 1992.


                                           By: /s/ Timothy J. Barberich
                                               ----------------------------
                                               Timothy J. Barberich,
                                               President

ATTEST:


By: /s/ Mark G. Borden
    ---------------------
    Mark G. Borden
    Secretary




<PAGE>



               Certificate of Designations of the Preferred Stock
                                       of
                                  Sepracor Inc.
                                To be Designated
                      Series A Convertible Preferred Stock
                      ------------------------------------

     Sepracor Inc., a Delaware corporation (the "Corporation"), pursuant to
authority conferred on the Board of Directors of the Corporation by the
Certificate of Incorporation and in accordance with the provisions of Section
151 of the General Corporation law of the State of Delaware, certifies that the
Board of Directors of the Corporation, by unanimous written consent in lieu of a
meeting, duly adopted the following resolution:

     RESOLVED: That, pursuant to the authority expressly granted to and vested
in the Board of Directors of the Corporation in accordance with the provisions
of its Certificate of Incorporation, a series of Preferred Stock of the
Corporation be and hereby is established, consisting of 80,000 shares, to be
designated "Series A Convertible Preferred Stock" (hereinafter "Series A
Preferred Stock"); that the Board of Directors be and hereby is authorized to
issue such shares of Series A Preferred Stock from time to time and for such
consideration and on such terms as the Board of Directors shall determine; and
that, subject to the limitations provided by law and by the Certificate of
Incorporation, the powers, designations, preferences and relative,
participating, optional or other special rights of, and the qualifications,
limitations or restrictions upon, the Series A Preferred Stock shall be as
follows:

     Eighty Thousand (80,000) shares of the authorized and unissued Preferred
Stock of the Corporation ("Series Preferred Stock") are hereby designated
"Series A Convertible Preferred Stock" (the Sseries A Preferred Stock") with the
following rights, preferences, powers, privileges and restrictions,
qualifications and limitations.

     1. Dividends.

          (a) The Corporation shall not declare or pay any distributions (as
defined below) on shares of Common Stock until the holders of the Series A
Preferred Stock then outstanding shall have first received, or simultaneously
receive, a dividend on each outstanding share of Series A Preferred Stock in an
amount at least equal to the product of (i) the per share amount, if any, of the
dividends or other distribution to be declared, paid or set aside for the Common
Stock, multiplied by (ii) the number of shares of Common Stock into which such
shares of Series A Preferred Stock is then convertible.


<PAGE>



          (b) For purposes of this Section 1, unless the context requires
otherwise, "distribution" shall mean the transfer of cash, securities or
property without consideration, whether by way of dividends or otherwise,
payable other than in Common Stock or other securities of the Corporation, or
the purchase or redemption of shares of the Corporation (other than repurchases
of Common Stock held by employees or directors of, or consultants to, the
Corporation upon termination of their employment or services pursuant to
agreements providing for such repurchase and other than redemptions in
liquidation or dissolution of the Corporation) for cash, securities or property,
including any such transfer, purchase or redemption by a subsidiary of this
Corporation.

     2. Liquidation, Dissolution or Winding Up.

          (a) In the event of any voluntary of involuntary liquidation,
dissolution or winding up of the Corporation, the holders of shares of Series A
Preferred Stock then outstanding shall be entitled to be paid out of the assets
of the Corporation available for distribution to its stockholders, after and
subject to the payment in full of all amounts required to be distributed to the
holders of any other class or series of stock of the Corporation ranking on
liquidation prior and in preference to the Series A Preferred Stock
(collectively referred to as "Senior Preferred Stock"), but before any payment
shall be made to the holders of Common Stock or any other class or series of
stock ranking on liquidation junior to the Series A Preferred Stock (such Common
Stock and other stock being collectively referred to as "Junior Stock") by
reason of their ownership thereof, an amount equal to $63.00 per share, together
with dividends or distributions required to be declared under Section 1(a). If
upon any such liquidation, dissolution or winding up of the Corporation the
remaining assets of the Corporation available for distribution to its
stockholders shall be insufficient to pay the holders of shares of Series A
Preferred Stock the full amount to which they shall be entitled, the holders of
shares of Series A Preferred Stock and any class or series of stock ranking on
liquidation on a parity with the Series A Preferred Stock shall hare ratably in
any distribution of the remaining assets and funds of the Corporation in
proportion to the respective amounts which would otherwise be payable in respect
of the shares held by them upon such distribution if all amounts payable on or
with respect to such shares were paid in full.

          (b) After the payment of all preferential amounts required to be paid
to the holders of Senior Preferred Stock, Series A Preferred Stock and any other
class or series of stock of the Corporation ranking on liquidation on a parity
with the Series A Preferred Stock, upon the dissolution, liquidation or winding
up of the Corporation, the holders of shares of Junior Stock then outstanding
shall be entitled to receive the remaining assets and funds of the Corporation
available for distribution to its stockholders.

          (c) In the event of any merger or consolidation of the Corporation
into or with another corporation (except one in which the holders of capital
stock of the Corporation immediately prior to such merger or consolidation
continue to hold


<PAGE>



at least 60% by voting power of the capital stock of the surviving corporation),
or the sale of all or substantially all of the assets of the Corporation where
the consideration payable to the holders of Series A Preferred Stock (in the
case of a merger or consolidation), or the consideration payable to such
holders, together with all other available assets of the Corporation (in the
case of an asset sale), is less than $63.00 per share of Series A Preferred
Stock, then, if the holders of at least a majority of the then outstanding
shares of Series A Preferred Stock so elect by giving written notice thereof to
the Corporation at least three days before the effective date of such event,
then such merger, consolidation or asset sale shall be deemed to be a
liquidation of the Corporation, and all consideration payable to the
stockholders of the Corporation (in the case of a merger or consolidation), or
all consideration payable to the Corporation, together with all other available
assets of the Corporation (in the case of an asset sale), shall be distributed
to the holders of capital stock of the Corporation in accordance with
Subsections 2(a) and 2(b) above. The Corporation shall promptly provide to the
holders of shares of Series A Preferred Stock such information concerning the
terms of such merger, consolidation or asset sale and the value of the assets of
the Corporation as may reasonably be requested by the holders of Series A
Preferred Stock in order to assist them in determining whether to make such an
election. The amount deemed distributed to the holders of Series A Preferred
Stock upon any such merger or consolidation shall be the cash or the value of
the property, rights or securities distributed to such holders by the acquiring
person, firm or other entity. The value of such property, rights or other
securities shall be reasonably determined by the Board of Directors of the
Corporation. If no notice of the election permitted by this Subsection (c) is
given, the provisions of Subsection 4(i) shall apply. Any other merger or
consolidation of the Corporation into or with another corporation shall not be
deemed to be a liquidation, dissolution, or winding up of the Corporation for
purposes of this Section 2.

     3. Voting.

          (a) Each holder of outstanding shares of Series A Preferred Stock
shall be entitled to the number of votes equal to the number of whole shares of
Common Stock into which the shares of Series A Preferred Stock held by such
holder are then convertible (as adjusted form time to time pursuant to Section 4
hereof), at each meeting of stockholders of the Corporation (and written actions
of stockholders in lieu of meetings) with respect to any and all matters
presented to the stockholders of the Corporation for their action or
consideration. Except as provided by law, or by the provisions establishing any
other series of Series Preferred Stock, holders of Series A Preferred Stock and
of any other outstanding series of Series Preferred Stock shall vote together
with the holders of Common Stock as a single class.

          (b) Without the consent of the holders of majority of the Series A
Preferred Stock, the Corporation shall not enter into any merger or
consolidation (except one in which the holders of capital stock of the
Corporation immediately prior to such merger or consolidation continue to hold
at least 60% by voting power of the capital stock of the surviving corporation)
or the sale of substantially all the


<PAGE>



assets of the Corporation where the consideration payable to the holders of the
Series A Preferred Stock shall have a value less than $63.00 per share, in the
same form as the consideration being given to the majority of shares of Common
Stock with the value being determined by an independent appraiser.

     4. Optional Conversion. The holders of the Series A Preferred Stock shall
have conversion rights as follows (the "Conversion Rights"):

          (a) Right to Convert. Each share of Series A Preferred Stock shall be
convertible, at the option of the holder thereof, at any time and from time to
time, and without the payment of additional consideration by the holder thereof,
into such number of fully paid and nonassessable shares of Common Stock as is
determined by dividing $63.00 by the Conversion Price (as defined below) in
effect at the time of conversion. The "Conversion Price" shall initially be
$6.30. Such initial Conversion Price, and the rate at which shares of Series A
Preferred Stock may be converted into shares of Common Stock, shall be subject
to adjustment as provided below.

          (b) Fractional Shares. No fractional shares of Common Stock shall be
issued upon conversion of the Series A Preferred Stock. In lieu of any
fractional shares to which the holder would otherwise be entitled, the
Corporation shall pay cash equal to such fraction multiplied by the then fair
market value of the Common Stock.

          (c) Mechanics of Conversion.

               (i) In order for a holder of Series A Preferred Stock to convert
shares of Series A Preferred Stock into shares of Common Stock, such holder
shall surrender the certificate or certificates for such shares of Series A
Preferred Stock, at the office of the transfer agent for the Series A Preferred
Stock (or at the principal office of the Corporation if the Corporation serves
as its own transfer agent), together with written notice that such holder elects
to convert all or any number of the shares of the Series A Preferred Stock
represented by such certificate or certificates. Such notice shall state such
holder's name or the names of the nominees in which such holder wishes the
certificate or certificates for shares of Common Stock to be issued. If required
by the Corporation, certificates surrendered for conversion shall be endorsed or
accompanied by a written instrument or instruments of transfer, in form
satisfactory to the Corporation, duly executed by the registered holder or his
or its attorney duly authorized in writing. The date of receipt of such
certificates and notice by the transfer agent (or by the Corporation if the
Corporation serves as its own transfer agent) shall be the conversion date
("Conversion Date"). The Corporation shall, as soon as practicable after the
Conversion Date, issue and deliver at such office to such holder of Series A
Preferred Stock, or to his or its nominees, a certificate or certificates for
the number of shares of Common Stock to which such holder shall be entitled,
together with cash in lieu of any fraction of a share.



<PAGE>



               (ii) The Corporation shall at all times when the Series A
Preferred Stock shall be outstanding, reserve and keep available out of its
authorized but unissued stock, for the purpose of effecting the conversion of
the Series A Preferred Stock, such number of its duly authorized shares of
Common Stock as shall from time to time be sufficient to effect the conversion
of all outstanding Series A Preferred Stock. Before taking any action which
would cause an adjustment reducing the Conversion Price below the then par value
of the shares of Common Stock issuable upon conversion of the Series A Preferred
Stock, the Corporation will take any corporate action which may, in the opinion
of its counsel, be necessary in order that the Corporation may validly and
legally issue fully paid and nonassessable shares of Common Stock at such
adjusted Conversion Price.

               (iii) Upon any such conversion, no adjustment of the Conversion
Price shall be made for any declared or accrued but unpaid dividends on the
Series A Preferred Stock surrendered for conversion or on the Common Stock
delivered upon conversion.

               (iv) All shares of Series A Preferred Stock which shall have been
surrendered for conversion as herein provided shall no longer be deemed to be
outstanding and all rights with respect to such shares, including the rights, if
any, to receive notices and to vote, shall immediately cease and terminate on
the Conversion Date, except only the right of the holders thereof to receive
shares of Common Stock in exchange therefor and payment of any dividends
declared but unpaid thereon. Any shares of Series A Preferred Stock so converted
shall be retired and cancelled and shall not be reissued, and the Corporation
(without the need for stockholder action) may from time to time take such
appropriate action as may be necessary to reduce the authorized Series A
Preferred Stock accordingly.

               (v) The Corporation shall pay any and all issue and other taxes
that may be payable in respect of any issuance or delivery of shares of Common
Stock upon conversion of shares of Series A Preferred Stock pursuant to this
Section 4. The Corporation shall not, however, be required to pay any tax which
may be payable in respect of any transfer involved in the issuance and delivery
of shares of Common Stock in a name other than that in which the shares of
Series A Preferred Stock so converted were registered, and no such issuance or
delivery shall be made unless and until the person or entity requesting such
issuance has paid to the Corporation the amount of any such tax or has
established, to the satisfaction of the Corporation, that such tax has been
paid.




<PAGE>



          (d) Adjustments to Conversion Price for Diluting Issues:

               (i) Special Definitions. For purposes of this Subsection 4(d),
the following definitions shall apply:

                    (A)  "Option" shall mean rights, options or warrants to
                         subscribe for, purchase or otherwise acquire Common
                         Stock or Convertible Securities, excluding options
                         described in subsection 4(d)(i)(D)(V) below.

                    (B)  "Original Issue Price" shall mean the date on which a
                         share of Series A Preferred Stock was first issued.

                    (C)  "Convertible Securities" shall mean any evidences of
                         indebtedness, shares or other securities directly or
                         indirectly convertible into or exchangeable for Common
                         Stock.

                    (D)  "Additional Shares of Common Stock" shall mean all
                         shares of Common Stock issued (or, pursuant to
                         Subsection 4(d)(iii) below, deemed to be issued) by the
                         Corporation after the Original Issue Date, other than
                         shares issued or issuable.

                    (E)  "Common Stock" shall be deemed to include equity
                         security having rights to receive dividends or
                         distributions (including liquidation) not limited to a
                         fixed sum or percentage of the purchase price therefor.
                         The price at which such securities are deemed issued
                         for purposes of this Section 4(d) shall take into
                         account as appropriate the relationship between the
                         terms thereof and the terms of the Series A Preferred
                         Stock:

                         (I)  upon exercise of any warrants or options or 
                              conversion of any  convertible securities of the 
                              Corporation outstanding prior to the Original 
                              Issuance Date;

                         (II) as a dividend or distribution on Series A 
                              Preferred Stock;

                         (III) by reason of a dividend, stock split, split-up or
                               other distribution on shares of Common Stock that
                               is covered by Subsection 4(e) or 4(f) below;


<PAGE>



                         (IV) in connection with the acquisition by the 
                              Corporation of another corporation of business;

                         (V)  to employees or directors of, or consultants to, 
                              the Corporation or any subsidiary as approved by
                              the Board of Directors of the Corporation, or

                         (VI) to pharmaceutical companies or other strategic 
                              partners in connection with a licensing, 
                              development, joint venture or similar arrangement
                              between the Corporation and such company or 
                              partner.

               (ii) No Adjustment of Conversion Price. No adjustment in the
number of shares of Common Stock into which the Series A Preferred Stock is
convertible shall be made, by adjustment in the applicable Conversion Price
thereof: (a) unless the consideration per share (determined pursuant to
Subsection 4(d)(v)) for an Additional Share of Common Stock issued or deemed to
be issued by the Corporation is less than the applicable Conversion Price in
effect on the date of, and immediately prior to, the issue of such Additional
Shares, or (b) if prior to such issuance, the Corporation receives written
notice from the holders of at least a majority of the then outstanding shares of
Series A Preferred Stock agreeing that no such adjustment shall be made as the
result of the issuance of Additional Shares of Common Stock.

               (iii) Issue of Securities Deemed Issue of Additional Shares of
Common Stock. If the Corporation at any time or from time to time after the
Original Issue Date shall issue any Options or Convertible Securities or shall
fix a record date for the determination of holders of any class of securities
entitled to receive any such Options or Convertible Securities, then the maximum
number of shares of Common Stock (as set forth in the instrument relating
thereto without regard to any provision contained therein for a subsequent
adjustment of such number) issuable upon the exercise of such Options or, in the
case of Convertible Securities and Options therefor, the conversion or exchange
of such Convertible Securities, shall be deemed to be Additional Shares of
Common Stock issued as of the time of such issue or, in case such a record date
shall have been fixed, as of the close of business on such record date, provided
that Additional Shares of Common Stock shall not be deemed to have been issued
unless the consideration per share (determined pursuant to Subsection 4(d)(v)
hereof) of such Additional Shares of Common Stock would be less than the
applicable Conversion Price in effect on the date of and immediately prior to
such issue, or such record date, as the case may be, and provided further that
in any such case in which Additional Shares of Common Stock are deemed to be
issued:



<PAGE>



                    (A)  No further adjustment in the Conversion Price shall be
                         made upon the subsequent issue of Convertible
                         Securities or shares of Common Stock upon the exercise
                         of such Options or conversion or exchange of such
                         Convertible Securities;

                    (B)  If such Options or Convertible Securities by their
                         terms provide, with the passage of time or otherwise,
                         for any increase or decrease in the consideration
                         payable to the Corporation, upon the exercise,
                         conversion or exchange thereof, the Conversion Price
                         computed upon the original issue thereof (or upon the
                         occurrence of a record date with respect thereto), and
                         any subsequent adjustments based thereon, shall, upon
                         any such increase or decrease becoming effective, be
                         recomputed to reflect such increase or decrease, as
                         applicable, insofar as it affects such Options or the
                         rights or conversion or exchange under such Convertible
                         Securities;

                    (C)  Upon the expiration or termination of and unexercised
                         Option, the Conversion Price shall not be readjusted;
                         and

                    (D)  No readjustment pursuant to clause (B) above shall have
                         the effect of increasing the Conversion Price to an
                         amount which exceeds the lower of (i) the Conversion
                         Price on the original adjustment date, or (ii) the
                         Conversion Price that would have resulted from any
                         issuances of Additional Shares of Common Stock between
                         the original adjustment date and such readjustment
                         date.

               (iv) Adjustment of Conversion Price Upon Issuance of Additional
Shares of Common Stock. In the event the Corporation shall at any time after the
Original Issue Date issue Additional Shares of Common Stock (including
Additional Shares of Common Stock deemed to be issued pursuant to Subsection
4(d)(iii), but excluding shares issued as a dividend or distribution as provided
in Subsection 4(f) or upon a stock split or combination as provided in
Subsection 4(e)), without consideration or for a consideration per share less
than the applicable Conversion Price in effect on the date of and immediately
prior to such issue, then and in such event, such Conversion Price shall be
reduced, concurrently with such issue, to a price equal to the consideration per
share received by the Corporation for the issue of the Additional Shares of
Common Stock (determined pursuant to Subsection 4(d)(v)).


<PAGE>



               (v) Determination of Consideration. For purposes of this
Subsection 4(d), the consideration received by the Corporation for the issue of
any Additional Shares of Common Stock shall be computed as follows:

                    (A)  Cash and Property. Such consideration shall:

                         (I)  insofar as it consists of cash, be computed at the
                              aggregate of cash received by the Corporation,
                              excluding amounts paid or payable for accrued
                              interest or accrued dividends;

                         (II) insofar as it consists of property other than
                              cash, be computed at the fair market value thereof
                              at the time of such issue, as reasonably
                              determined by the Board of Directors; and

                        (III) in the event Additional Shares of Common Stock
                              are issued together with other shares or
                              securities or other assets of the Corporation for
                              consideration which covers both, be the proportion
                              of such consideration so received, computed as
                              provided in clauses (I) and (II) above, as
                              reasonably determined by the Board of Directors.

                    (B) Options and Convertible Securities. The consideration
per share received by the Corporation for Additional Shares of Common Stock
deemed to have been issued pursuant to Subsection 4(d)(iii), relating to Options
and Convertible Securities, shall be determined by dividing

                         (x)  the total amount, if any, received or receivable
                              by the Corporation as consideration for the issue
                              of such Options or Convertible Securities, plus
                              the minimum aggregate amount of additional
                              consideration (as set forth in the instruments
                              relating thereto, without regard to any provision
                              contained therein for a subsequent adjustment of
                              such consideration) payable to the Corporation
                              upon the exercise of such Options or the
                              conversion or exchange of such Convertible
                              Securities, or in the case of Options for
                              Convertible Securities, the exercise of such
                              Options for Convertible


<PAGE>



                              Securities and the conversion or exchange of such
                              Convertible Securities, by

                         (y)  the maximum number of shares of Common Stock (as
                              set forth in the instruments relating thereto,
                              without regard to any provision contained therein
                              for a subsequent adjustment of such number)
                              issuable upon the exercise of such Options or the
                              conversion or exchange of such Convertible
                              Securities.

          (e) Adjustment for Stock Splits and Combinations. If the Corporation
shall at any time or from time to time after the Original Issue Date effect a
subdivision of the outstanding Common Stock, the Conversion Price then in effect
immediately before that subdivision shall be proportionately decreased. If the
Corporation shall at any time or from time to time after the Original Issue Date
effect a subdivision of the Series A Preferred Stock, the Conversion Price then
in effect immediately before that subdivision shall be proportionately
increased. If the Corporation shall at any time or from time to time after the
Original Issue Date combine the outstanding shares of Common Stock, the
Conversion Price then in effect immediately before the combination shall be
proportionately increased. If the Corporation shall at any time or from time to
time after the Original Issue Date combine the outstanding shares of Series A
Preferred Stock, the Conversion Price then in effect immediately before the
combination shall be proportionately decreased. Any adjustment under this
paragraph shall become effective at the close of business on the date the
subdivision or combination becomes effective.

          (f) Adjustment for Certain Dividends and Distributions. In the event
the Corporation at any time, or from time to time after the Original Issue Date
shall make or issue, or fix a record date for the determination of holders of
Common Stock entitled to receive, a dividend or other distribution payable in
additional shares of Common Stock, then and in each such event the Conversion
Price for the Series A Preferred Stock then in effect shall be decreased as of
the time of such issuance or, in the event such a record date shall have been
fixed, as of the close of business on such record date, by multiplying the
Conversion Price for the Series A Preferred Stock then in effect by a fraction:

               (1) the numerator of which shall be the total number of
          shares of Common Stock issued and outstanding immediately prior
          to the time of such issuance or the close of business on such
          record date, and

               (2) the denominator of which shall be the total number of
          shares of Common Stock issued and outstanding immediately prior
          to the time of such issuance or the close of business on such
          record date plus the number of shares of Common Stock issuable in
          payment of such dividend or distribution;


<PAGE>



          provided, however, if such record date shall have been fixed and
          such dividend is not fully paid or if such distribution is not
          fully made on the date fixed therefore the Conversion Price for
          the Series A Preferred Stock shall be recomputed accordingly as
          of the close of business on such record date and thereafter the
          Conversion Price for the Series A Preferred Stock shall be
          adjusted pursuant to this paragraph as of the time of actual
          payment of such dividends or distributions; and provided further,
          however, that no such adjustment shall be made if the holders of
          Series A Preferred Stock simultaneously receive a dividend or
          other distribution of shares of Common Stock in a number equal to
          the number of shares of Common Stock as they would have received
          if all outstanding shares of Series A Preferred Stock had been
          converted into Common Stock on the date of such event.

          (g) Prohibition on Certain Dividends and Distributions. The
Corporation shall not, at any time or from time to time after the Original Issue
Date for the Series A Preferred Stock, make or issue, or fix a record date for
the determination of holders of Common Stock entitled to receive, a dividend or
other distribution payable in securities of the Corporation other than shares of
Common Stock, unless the holders of Series A Preferred Stock simultaneously
receive a dividend or other distribution of such securities in an amount equal
to the amount of such securities as they would have received if all outstanding
shares of Series A Preferred Stock had been converted into Common Stock on the
date of such event.

          (h) Adjustment for Reclassification, Exchange or Substitution. If the
Common Stock issuable upon the conversion of the Series A Preferred Stock shall
be changed into the same or a different number of shares of any class or classes
of stock, whether by capital reorganization, reclassification, or otherwise
(other than a subdivision or combination of shares or stock dividend provided
for above, or a reorganization, merger, consolidation, or sale of assets
provided for below), then and in each such event the holder of each such share
of Series A Preferred Stock shall have the right thereafter to convert such
share into the kind and amount of shares of stock and other securities and
property receivable upon such reorganization, reclassification, or other change,
by holders of the number of shares of Common Stock into which such shares of
Series A Preferred Stock might have been converted immediately prior to such
reorganization, reclassification, or change, all subject to further adjustment
as provided herein.

          (i) Adjustment for Merger or Reorganization, etc. In case of any
consolidation or merger of the Corporation with or into another corporation or
the sale of all or substantially all of the assets of the Corporation to another
corporation, each share of Series A Preferred Stock shall thereafter be
convertible (or shall be converted into a security which shall be convertible)
into the kind and amount of shares of stock or other securities or property to
which a holder of the number of shares of Common Stock of the Corporation
deliverable upon conversion of such Series A Preferred Stock would have been
entitled upon such consolidation, merger or sale; and, in such case, appropriate
adjustment (as reasonably determined by the Board of Directors) shall be made in
the application of the provisions in this Section 4


<PAGE>



set forth with respect to the rights and interest thereafter of the holders of
the Series A Preferred Stock, to the end that the provisions set forth in this
Section 4 (including provisions with respect to changes in and other adjustments
of the Conversion Price) shall thereafter be applicable, as nearly as reasonably
may be, in relation to any shares of stock or other property thereafter
deliverable upon the conversion of the Series A Preferred Stock.

          (j) No Impairment. The Corporation will not, by amendment of its
Certificate of Incorporation or through any reorganization, transfer of assets,
consolidation, merger, dissolution, issue or sale of securities or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the terms to be observed or performed hereunder by the Corporation, but will at
all times in good faith assist in the carrying out of all the provisions of this
Section 4 and in the taking of all such action as may be necessary or
appropriate in order to protect the Conversion Rights of the holders of the
Series A Preferred Stock against impairment. If any event occurs as to which the
provisions of this Section 4 are not applicable or if applicable would not
fairly protect the rights of the holders of Series A Preferred Stock in
accordance with the essential intent and principles of such provisions, the
application of such provisions will be adjusted in accordance with such
essential intent and principles so as to protect such rights, but in no event
shall the Conversion Price be increased.

          (k) Certificate as to Adjustments. Upon the occurrence of each
adjustment or readjustment of the Conversion Price pursuant to this Section 4,
the Corporation at its expense shall promptly compute such adjustment or
readjustment in accordance with the terms hereof and furnish to each holder of
Series A Preferred Stock a certificate setting forth such adjustment or
readjustment and showing in detail the facts upon which such adjustment or
readjustment is based. The Corporation shall, upon the written request at any
time of any holder of Series A Preferred Stock, furnish or cause to be furnished
to such holder a similar certificate setting forth (i) such adjustments and
readjustments, (ii) the Conversion Price then in effect, and (iii) the number of
shares of Common Stock and the amount, if any, of other property which then
would be received upon the conversion of Series A Preferred Stock.

          (l) Notice of Record Date. In the event:

               (i)  that the Corporation declares a dividend (or any other
                    distribution) on its Common Stock payable in Common Stock or
                    other securities of the Corporation;

               (ii) that the Corporation subdivides or combines its outstanding
                    shares of Common Stock;

              (iii) of any reclassification of the Common Stock of the
                    Corporation (other than a subdivision or combination of its


<PAGE>



                    outstanding shares of Common Stock or a stock dividend or
                    stock distribution thereon), or of any consolidation or
                    merger of the Corporation into or with another corporation,
                    or of the sale of all or substantially all of the assets of
                    the Corporation; or

               (iv) of the involuntary or voluntary dissolution, liquidation or
                    winding upon of the Corporation;

then the Corporation shall cause to be filed at its principal office or at the
office of the transfer agent of the Series A Preferred Stock, and shall cause to
be mailed to the holders of the Series A Preferred Stock at their last addresses
as shown on the records of the Corporation or such transfer agent, at least ten
days prior to the date specified in (A) below or twenty days before the date
specified in (B) below, a notice stating

     (A)  the record date of such dividend, distribution, subdivision or
          combination, or, if a record is not to be taken, the date as of which
          the holders of Common Stock of record to be entitled to such dividend,
          distribution, subdivision or combination are to be determined, or

     (B)  the date on which such reclassification, consolidation, merger, sale,
          dissolution, liquidation or winding up is expected to become
          effective, and the date as of which it is expected that holders of
          Common Stock of record shall be entitled to exchange their shares of
          Common Stock for securities or other property deliverable upon such
          reclassification, consolidation, merger, sale, dissolution or winding
          up.

     5. Mandatory Conversion.

        (a) All outstanding shares of Series A Preferred Stock shall
automatically be converted into shares of Common Stock, at the then effective
conversion rate, upon the earlier of (i) September 30, 2004 or (ii) upon written
notice by the Corporation to the holders of Series A Preferred Stock (which
notice may not be delivered prior to September 30, 1995) following a period of
twenty (20) consecutive trading days in which the lst reported sales price of
the Common Stock on the Nasdaq National Market (or a national securities
exchange) equals or exceeds 160% of the then effective Conversion Price (the
"Mandatory Conversion Date").

        (b) All holders of record of shares of Series A Preferred Stock will be
given written notice of the Mandatory Conversion Date and the place designated
for mandatory conversion of all such shares of Series A Preferred Stock pursuant
to this Section 5. Such notice shall be sent by first class or registered mail,
postage prepaid, to each record holder of Series A Preferred Stock at such
holder's address last shown


<PAGE>



on the records of the transfer agent for the Series A Preferred Stock (or the
records of the Corporation, if it serves as its own transfer agent). Upon
receipt of such notice, each holder of shares of Series A Preferred Stock shall
surrender his or its certificate or certificates for all such shares to the
Corporation at the place designated in such notice, and shall thereafter receive
certificates for the number of shares of Common Stock to which such holder is
entitled pursuant to this Section 5. On the Mandatory Conversion Date, all
rights with respect to the Series A Preferred Stock so converted, including the
rights, if any, to receive notices and vote, will terminate, except only the
rights of the holders thereof, upon surrender of their certificate or
certificates therefor, to receive certificates for the number of shares of
Common Stock into which such Series A Preferred Stock has been converted, and
payment of any declared but unpaid dividends thereon and any dividends or
distributions required to be declared under Section 1(a). If so required by the
Corporation, certificates surrendered for conversion shall be endorsed or
accompanied by written instrument or instruments of transfer, in form
satisfactory to the Corporation, duly executed by the registered holder or by
his or its attorney duly authorized in writing. As soon as practicable after the
Mandatory Conversion Date and the surrender of the certificate or certificates
for Series A Preferred Stock, the Corporation shall cause to be issued and
delivered to such holder, or on his or its written order, a certificate or
certificates for the number of full shares of Common Stock issuable on such
conversion in accordance with the provisions hereof and cash as provided in
Subsection 4(b) in respect of any fraction of a share of Common Stock otherwise
issuable upon such conversion.

        (c) All certificates evidencing shares of Series A Preferred Stock which
are required to be surrendered for conversion in accordance with the provisions
hereof shall, from and after the Mandatory Conversion Date, be deemed to have
been retired and cancelled and the shares of Series A Preferred Stock
represented thereby converted into Common Stock for all purposes,
notwithstanding the failure of the holder or holders thereof to surrender such
certificates on or prior to such date. The Corporation may thereafter take such
appropriate action (without the need for stockholder action) as may be necessary
to reduce the authorized Series A Preferred Stock accordingly.





<PAGE>



        IN WITNESS WHEREOF, the Corporation has caused its corporate seal to be
affixed hereto and this Certificate of Amendment to be signed by its President
and attested to by its Assistant Secretary this 30th day of September, 1994.


                                             SEPRACOR INC. 



                                             By:/s/ Timothy J. Barberich 
                                                -------------------------
                                                Timothy J. Barberich
                                                President

ATTEST:


/s/ Victor Woolley
- -------------------------
Victor Woolley
Assistant Secretary

[Corporate Seal]




<PAGE>



                            CERTIFICATE OF CORRECTION
                       FILED TO CORRECT CERTAIN ERRORS IN

                       THE CERTIFICATE OF DESIGNATIONS OF
                             THE PREFERRED STOCK OF

                                  SEPRACOR INC.

                                TO BE DESIGNATED
                      SERIES A CONVERTIBLE PREFERRED STOCK

FILED IN THE OFFICE OF THE SECRETARY OF STATE OF DELAWARE ON SEPTEMBER 30, 1994.

     SEPRACOR INC., a corporation organized and existing under and by virtue of
the General Corporation Law of the State of Delaware,

     DOES HEREBY CERTIFY:

     1.   The name of the corporation is Sepracor Inc.

     2.   The Certificate of Designations of the Preferred Stock of Sepracor
          Inc. to be designated Series A Convertible Preferred Stock was filed
          with the Secretary of State of the State of Delaware on September 30,
          1994 and that said certificate requires corrections permitted by
          subsection (f) of Section 103 of the General Corporation Law of the
          State of Delaware.

     3.   The inaccuracies or defects of said certificate to be corrected are as
          follows:

          (a)  Certain words were inadvertently omitted from Subsection (b) of
               Section 3;

          (b)  A typographical error is included in Subsection (d)(i)(D)(I) of
               Section 4;

          (c)  Subsection (d)(i)(E) of Section 4 was inadvertently located
               within subsection (d)(i)(D);

          (d)  The final page of said certificate was inadvertently numbered as
               page 15.




<PAGE>



     In order to correct said inaccuracies or defects, the following shall
occur:

          (a)  Subsection (b) of Section 3 shall read in its entirety:

          Without the consent of the holders of a majority of the shares of
          Series A Preferred Stock then outstanding, the Corporation shall not
          enter into any merger or consolidation (except one in which the
          holders of capital stock of the Corporation immediately prior to such
          merger or consolidation continue to hold at least 60% by voting power
          of the capital stock of the surviving corporation) or the sale of
          substantially all the assets of the Corporation where the
          consideration payable to the holders of the Series A Preferred Stock
          shall have a value less than $63.00 per share in the same form as the
          consideration being given to the majority of shares of Common Stock
          with the value being determined by an independent appraiser.";

          (b)  The words "Original Issuance Date" in Subsection (d)(i)(D)(I) of
               Section 4 shall be changed to "Original Issue Date.";

          (c)  Subsection (d)(i)(E) of Section 4, shall be relocated to
               immediately follow subsection (d)(i)(D)(VI) of Section 4;

          (d)  The final page shall be renumbered as page 16.

     IN WITNESS WHEREOF, said Sepracor Inc. has caused this certificate to be
signed by Timothy J. Barberich, its President, and attested by Victor H.
Woolley, its Assistant Secretary, this 28 day of October, 1994.

                                               SEPRACOR INC.


                                               By:/s/ Timothy J. Barberich
                                                  --------------------------
                                                  Timothy J. Barberich
                                                  President


ATTEST:


By:/s/ Victor Woolley
   ------------------------
    Victor Woolley
    Assistant Secretary





<PAGE>



                    CERTIFICATE OF DESIGNATIONS, PREFERENCES,
                    AND RELATIVE, PARTICIPATING, OPTIONAL AND
                     OTHER SPECIAL RIGHTS OF PREFERRED STOCK
                         AND QUALIFICATIONS, LIMITATIONS
                            AND RESTRICTIONS THEREOF

                                       OF

                SERIES B REDEEMABLE EXCHANGEABLE PREFERRED STOCK

                                       OF

                                  SEPRACOR INC.
                              --------------------

                         Pursuant to Section 151 of the
                General Corporation Law of the State of Delaware
                              --------------------


     Sepracor Inc., a Delaware corporation (the "Corporation"), certifies that
pursuant to the authority contained in Article FOURTH of its Restated
Certificate of Incorporation (the "Certificate of Incorporation") and in
accordance with the provisions of Section 151 of the General Corporation Law of
the State of Delaware, the Board of Directors of the Corporation, at a meeting
duly called and held, at which a quorum was present and acting throughout, duly
adopted the following resolution, which resolution remains in full force and
effect on the date hereof:

     RESOLVED, that there is hereby established a series of authorized Preferred
Stock having a par value of $1.00 per share, which series shall be designated
"Series B Redeemable Exchangeable Preferred Stock" (hereinafter "Series B
Preferred Stock"), shall consist of 312,500 shares and shall have the following
powers, preferences and relative, participating, optional and other special
rights, and qualifications, limitations and restrictions thereof:

     1. Dividends. Holders of shares of Series B Preferred Stock shall be
entitled to receive, when, as and if declared by the Board of Directors out of
funds legally available therefor, an annual cash dividend of $1.92 per share,
payable on each March 8 after the date of issuance of Series B Preferred Stock
until March 8, 2000. Such dividends shall accrue from day to day and shall be
cumulative from the date of issuance of each share of Series B Preferred Stock,
whether or not declared. After March 8, 2000, no dividends shall accrue on
outstanding shares of Series B Preferred Stock. Dividends will be payable to
holders of record as they appear on the stock records of the Corporation on such
record dates, not more than 60 days preceding the applicable payment date, as
shall be fixed by the Board of Directors of


<PAGE>



               the Corporation. Dividends payable for any partial period shall
               be calculated on the basis of a 360-day year, and accrued but
               unpaid dividends shall not bear interest.

     2.   Liquidation, Dissolution or Winding Up: Certain Mergers and
          Consolidations.

          (a) In the event of any voluntary or involuntary liquidation,
dissolution or winding up of the Corporation, the holders of shares of Series B
Preferred Stock then outstanding shall be entitled to be paid out of the assets
of the Corporation available for distribution to its stockholders, after and
subject to payment in full of all amounts required to be distributed to any
class or series of stock of the Corporation ranking on liquidation prior and in
preference to the Series B Preferred Stock (such stock being collectively
referred to as the "Senior Preferred Stock"), but before any payment shall be
made to the holders of the common stock, par value $0.10 per share, of the
Corporation ("Common Stock") or any other class or series of stock ranking on
liquidation junior to the Series B Preferred Stock (such Common Stock and other
stock being collectively referred to as "Junior Stock") by reason of their
ownership thereof, an amount equal to $16.00 per share (subject to appropriate
adjustment in the event of any stock dividend, stock split, combination or other
similar recapitalization affecting such shares), plus any dividends declared or
accrued but unpaid on such shares. The Series A Convertible Preferred Stock of
the Corporation (the "Series A Preferred Stock") shall rank on liquidation on a
parity with the Series B Preferred Stock. If upon any such liquidation,
dissolution or winding up of the Corporation the remaining assets of the
Corporation available for distribution to the stockholders shall be insufficient
to pay the holders of shares of Series A Preferred Stock and Series B Preferred
Stock the full amount to which they shall be entitled, the holders of shares of
Series A Preferred Stock, Series B Preferred Stock and any class or series of
stock ranking on liquidation on a parity with the Series A Preferred Stock and
the Series B Preferred Stock shall share ratably in any distribution of the
remaining assets and funds of the Corporation in proportion to the respective
amounts which would otherwise be payable in respect of the shares held by them
upon such distribution if all amounts payable on or with respect to such shares
were paid in full.

          (b) After the payment of all preferential amounts required to be paid
to the holders of Senior Preferred Stock, Series A Preferred Stock, Series B
Preferred Stock and any other class or series of stock of the Corporation
ranking on liquidation on a parity with the Series B Preferred Stock, upon the
dissolution, liquidation or winding up of the Corporation, the holders of shares
of Junior Stock then outstanding shall be entitled to receive the remaining
assets and funds of the Corporation available for distribution to its
stockholders.

          (c) At least 20 days prior to the date of any dissolution, liquidation
or winding up of the Corporation, the Corporation shall give notice thereof in
the manner provided by Section 5(c) hereof in order to permit the holders of
Series B


<PAGE>



Preferred Stock to exercise their right to exchange such shares before their
Exchange Rights (as defined in Section 5 hereof) terminate.

          (d) In the event of any merger or consolidation pursuant to which
holders of outstanding shares of Common Stock exchange such shares for cash,
property and/or securities of another corporation or entity (a "Qualified
Merger"), then such merger or consolidation shall be deemed to be a liquidation
of the Corporation for purposes of this Section 2.

     3. Voting. Except as otherwise required by law, holders of Series B
Preferred Stock shall not be entitled to any voting rights by virtue of such
ownership.

     4. Restriction on Creation of Certain Senior Shares. So long as any Series
B Preferred Stock shall be outstanding, the Corporation shall not, without the
prior written approval of holders of a majority of the Series B Preferred Stock
then outstanding, create any class or series of stock ranking, as to payment of
dividends or liquidation preference, equal or prior to the Series B Preferred
Stock if the terms of such stock in any way restrict the Corporation's ability
to comply with the powers, preferences and special rights of the Series B
Preferred Stock other than in connection with the operation of the preference
upon liquidation, dissolution or winding up (or deemed liquidation) of such
other class or series of stock as set forth in Section 2 hereof.

     5. Optional Exchange. The holders of Series B Preferred Stock shall have
exchange rights as follows (the "Exchange Rights"):

          (a)  Right to Exchange.

               (i) At any time after the earlier of (A) 20 days prior to March
8, 2000, (b) the date, prior to March 8, 2000, on which the shares of common
stock, $0.01 par value per share (the "BioSepra Common Stock"), of BioSepra
Inc., a Delaware corporation ("BioSepra") have a closing price as reported by
the Wall Street Journal (or if the Wall Street Journal is not then being
published, publications of similar reliability and repute), greater than 112.5%
of the Exchange Price (as determined in accordance with the provisions of this
Section 5), (C) 20 days prior to a BioSepra Event (as defined in Subsection
5(a)(ii) below), (D) 20 days prior to the date of any redemption made pursuant
to Section 6 or 7 hereof or (E) 20 days prior to the date of any dissolution,
liquidation or winding up of the Corporation pursuant to Section 2 hereof,
subject to funds legally available therefor, each share of Series B Preferred
Stock shall be exchangeable, at the option of the holder thereof, and without
the payment of additional consideration by the holder thereof, for such number
of outstanding shares of BioSepra Common Stock held by the Corporation (the
"Owned BioSepra Common Stock") as is determined by dividing $16.00 by the
Exchange Price (as defined below) in effect at the time of exchange. The
"Exchange Price" shall initially be $16.00. Such initial Exchange Price, and the
rate at which shares of Series B Preferred Stock may be exchanged for shares of
BioSepra Common


<PAGE>



Stock, shall be subject to adjustment as provided below. No declared or accrued
but unpaid dividends shall be paid upon such exchange.

               (ii) In the event of a Change of Control of BioSepra, as defined
in Section 7(b) hereof (a "BioSepra Event"), the Exchange Rights may be
exercised at the option of each holder of Series B Preferred Stock prior to the
effectiveness of the BioSepra Event pursuant to the following:

                    (A) The Corporation shall use its best efforts to provide
written notice to each holder of Series B Preferred Stock at least 20 days prior
to the date on which the BioSepra Event is expected to become effective,
notifying such holder of (I) the date on which the BioSepra Event is expected to
become effective and (II) the date as of which the holders of record of BioSepra
Common Stock shall be entitled to any consideration to be paid to such holders
pursuant to the BioSepra Event; and

                    (B) Subsequent to the receipt of such written notice
pursuant to clause (A) above by each holder of Series B Preferred Stock, the
Corporation and each holder of such stock shall use their respective best
efforts to effectuate such an optional exchange (pursuant to the provisions of
Subsection 5(a)(i) hereof and Section 5(c) hereof) to insure that those holders
of Series B Preferred Stock who exercise their Exchange Rights shall be holders
of BioSepra Common Stock prior to the effectiveness of the BioSepra Event.

               (iii) In the event of a notice of any redemption of shares of
Series B Preferred Stock pursuant to Sections 6 or 7 hereof, the Exchange Rights
of the holders of the shares designated for redemption shall terminate at the
close of business on the second full day preceding the date fixed for
redemption, unless the redemption price is not paid when due, in which case the
Exchange Rights for such shares shall continue until such price is paid in full.
In the event of a liquidation of the Corporation pursuant to Section 2 hereof,
the Exchange Rights shall terminate at the close of business on the first full
day preceding the date fixed for the payment of any amounts distributable on
liquidation to the holders of Series B Preferred Stock.

               (iv) With respect solely to shares of BioSepra Common Stock
obtained pursuant to an exchange governed by Sections 5(a)(i)(B) or 5(a)(i)(C)
above, holders of such shares of BioSepra Common Stock shall, upon such
exchange, provide a proxy to the Board of Directors of the Corporation or their
designees (expiring on March 8, 2000) for the voting of such shares with respect
to any vote of the stockholders of BioSepra regarding any BioSepra Event.

          (b) Fractional Shares. No fractional share of BioSepra Common Stock
shall be issued upon exchange of the Series B Preferred Stock. In lieu of any
fractional shares to which the holder would otherwise be entitled, the
Corporation shall pay cash equal to such fraction multiplied by the then
effective Exchange Price.



<PAGE>



          (c) Mechanics of an Optional Exchange.

               (i) In order for each holder of Series B Preferred Stock to
exchange shares of Series B Preferred Stock for shares of BioSepra Common Stock,
such holder shall surrender the certificate or certificates for such shares of
Series B Preferred Stock at the principal office of the Corporation, together
with written notice to the Corporation that such holder elects to exchange all
or any number of the shares of Series B Preferred Stock represented by such
certificate or certificates. Such notice shall state such holder's name or the
names of the nominees in which such holder wishes the certificate or
certificates for shares of BioSepra Common Stock to be issued. If required by
the Corporation, certificates surrendered for exchange shall be endorsed or
accompanied by a written instrument or instruments of transfer, in form
reasonably satisfactory to the Corporation, duly executed by the registered
holder or his or its attorney duly authorized in writing. The date of receipt of
such certificates and notice by the Corporation shall be the exchange date (the
"Exchange Date"). The Corporation shall, as soon as practicable after the
Exchange Date, deliver at such office to such holder of Series B Preferred
Stock, or to his or its nominees, a certificate or certificates for the number
of shares of BioSepra Common Stock to which such holder shall be entitled,
together with cash in lieu of any fraction of a share. On and after the Exchange
Date, such holder or his or its nominees shall be deemed to be the record owner
of such shares of BioSepra Common Stock and have all the rights appertaining
thereto.

               (ii) The Corporation shall at all times when the Series B
Preferred Stock shall be outstanding, reserve for the purpose of effecting the
exchange of the Series B Preferred Stock, such number of its shares of BioSepra
Common Stock as shall from time to time be sufficient to effect the exchange of
all outstanding Series B Preferred Stock.

               (iii) All shares of Series B Preferred Stock which shall have
been surrendered for exchange as herein provided shall no longer be deemed to be
outstanding and all rights with respect to such shares, including the right, if
any, to receive notices and to vote, shall immediately cease and terminate on
the Exchange Date, except only the right of the holders thereof to receive
certificates representing shares of BioSepra Common Stock in exchange therefor.
Any shares of Series B Preferred Stock so exchanged shall be retired and
cancelled and shall not be reissued, and the Corporation (without the need for
stockholder action) may from time to time take such appropriate action as may be
necessary to reduce the authorized Series B Preferred Stock accordingly.




<PAGE>



          (d) Adjustments to Exchange Price for Diluting Issues.

               (i) Special Definitions. For purposes of this Section 5(d), the
following definitions shall apply:

                    (A) "Option" shall mean rights, options or warrants to
subscribe for, purchase or otherwise acquire BioSepra Common Stock or
Exchangeable Securities (as defined below), excluding options granted to persons
described in Subsection 5(d)(i)(D)(IV) hereof.

                    (B) "Original Issue Date" shall mean March 8, 1995.

                    (C) "Exchangeable Securities" shall mean any evidences of
indebtedness, shares or other securities directly or indirectly convertible into
or exchangeable for BioSepra Common Stock.

                    (D) "Additional Shares of BioSepra Common Stock" shall mean
all shares of BioSepra Common Stock issued (or, pursuant to Subsection 5(d)(iii)
hereof, deemed to be issued) by BioSepra after the Original Issue Date, other
than shares issued or issuable:

                         (I)  upon exercise of any warrants or options or
                              conversion of any convertible securities of
                              BioSepra outstanding immediately prior to the
                              Original Issue Date;
     
                         (II) by reason of a dividend, stock split, split-up or
                              other distribution on shares of BioSepra Common
                              Stock that is covered by Subsection 5(e) or 5(f)
                              hereof;

                        (III) in connection with the acquisition by BioSepra of
                              another corporation or business;

                         (IV) to employees or directors of, or consultants to,
                              BioSepra or any subsidiary as approved by the
                              Board of Directors of BioSepra; or

                         (V)  to pharmaceutical companies or other strategic
                              partners in connection with a licensing,
                              development, joint venture or similar arrangement
                              between BioSepra and such company or partner.

                    (E) The BioSepra Common Stock shall be deemed to
include any equity security having rights to receive dividends or
distributions


<PAGE>



(including liquidation) not limited to a fixed sum or percentage of the
purchase price therefor.

                    (F) "Initial Shares Outstanding" shall mean the number
of shares of BioSepra Common Stock issued and outstanding immediately prior
to an adjustment of the Exchange Price pursuant to Subsection 5(d)(iv)
hereof.

               (ii) No Adjustment of Exchange Price. No adjustment in the
number of shares of BioSepra Common Stock into which the Series B Preferred
Stock is exchangeable shall be made, by adjustment in the applicable
Exchange Price thereof: (a) unless the consideration per share (determined
pursuant to Subsection 5(d)(v) hereof) for an Additional Share of BioSepra
Common Stock issued or deemed to be issued by BioSepra is less than the
applicable Exchange Price in effect on the date of, and immediately prior
to, the issue of such Additional Shares, or (b) if prior to such issuance,
the Corporation receives written notice from the holders of at least a
majority of the then outstanding shares of Series B Preferred Stock
agreeing that no such adjustment shall be made as the result of the
issuance of Additional Shares of BioSepra Common Stock.

               (iii) Issue of Securities Deemed Issue of Additional Shares
of BioSepra Common Stock. If BioSepra at any time or from time to time
after the Original Issue Date shall issue any Options or Exchangeable
Securities or shall fix a record date for the determination of holders of
any class of securities entitled to receive any such options or
Exchangeable Securities, then the maximum number of shares of BioSepra
Common Stock (as set froth in the instrument relating thereto without
regard to any provision contained therein for a subsequent adjustment of
such number) issuable upon the exercise of such Options or, in the case of
Exchangeable Securities and Options therefor, the conversion or exchange of
such Exchangeable Securities, shall be deemed to be Additional Shares of
BioSepra Common Stock issued as of the time of such issue or, in case such
a record date shall have been fixed, as of the close of business on such
record date, provided that Additional Shares of BioSepra Common Stock shall
not be deemed to have been issued unless the consideration per share
(determined pursuant to Subsection 5(d)(v) hereof) of such Additional
Shares of BioSepra Common Stock would be less than the applicable Exchange
Price in effect on the date of and immediately prior to such issue, or such
record date, as the case may be, and provided further that in any such case
in which Additional Shares of BioSepra Common Stock are deemed to be
issued:

                    (A) No further adjustment in the Exchange Price shall
be made upon the subsequent issue of Exchangeable Securities or shares of
BioSepra Common Stock upon the exercise of such Options or conversion or
exchange of such Exchangeable Securities;

                    (B) If such Options or Exchangeable Securities by their
terms provide, with the passage of time or otherwise, for any increase or
decrease in the consideration payable to the Corporation, upon the
exercise, conversion or


<PAGE>



exchange thereof, the Exchange Price computed upon the original issue
thereof (or upon the occurrence of a record date with respect thereto), and
any subsequent adjustments based thereon, shall, upon any such increase or
decrease becoming effective, be recomputed to reflect such increase or
decrease, as applicable, insofar as it affects such Options or the rights
of conversion or exchange under such Exchangeable Securities;

                    (C) Upon the expiration or termination of any
unexercised Option, the Exchange Price shall not be readjusted; and

                    (D) No readjustment pursuant to clause (B) above shall
have the effect of increasing the Exchange Price to an amount which exceeds
the lower of (I) the Exchange Price on the original adjustment date, or
(II) the Exchange Price that would have resulted from any issuances of
Additional Shares of BioSepra Common Stock between the original adjustment
date and such readjustment date.

               (iv) Adjustment of Exchange Price Upon Issuance of
Additional Shares of BioSepra Common Stock. In the event BioSepra shall at
any time after the Original Issue Date issue Additional Shares of BioSepra
Common Stock (including Additional Shares of BioSepra Common Stock deemed
to be issued pursuant to Subsection 5(d)(iii) hereof, but excluding shares
issued upon a stock split or combination as provided in Section 5(d) hereof
or as a dividend or distribution as provided in Section 5(f) hereof),
without consideration or for a consideration per share less than the
applicable Exchange Price in effect on the date of and immediately prior to
such issue, then and in such event, such Exchange Price shall be reduced,
concurrently with such issue, to a price equal to the greater of (i) $12.00
(as proportionately adjusted in the event the Exchange Price is or has been
subject to adjustment pursuant to Sections 5(e) or 5(f) hereof) and (ii)
such Exchange Price multiplied by a fraction, the numerator of which is the
Initial Shares Outstanding and the denominator of which is the Initial
Shares Outstanding plus the number of such Additional Shares of BioSepra
Common Stock.

               (v) Determination of Consideration. For purposes of this
Section 5(d), the consideration received by BioSepra for the issue of any
Additional Shares of BioSepra Common Stock shall be computed as follows:

                    (A) Cash and Property. Such consideration shall:

                         (I)  insofar as it consists of cash, be computed at the
                              aggregate of cash received by BioSepra, excluding
                              amounts paid or payable for accrued interest or
                              accrued dividends;

                         (II) insofar as it consists of property other than
                              cash, be computed at the fair market value thereof
                              at the time of such issue, as


<PAGE>



                              reasonably determined by the Board of Directors of
                              BioSepra; and

                        (III) in the event Additional Shares of BioSepra Common
                              Stock are issued together with other shares or
                              securities or other assets of BioSepra for
                              consideration which covers both, be the proportion
                              of such consideration so received, computed as
                              provided in clauses (I) and (II) above, as
                              reasonably determined by the Board of Directors of
                              BioSepra.

                    (B) Options and Exchangeable Securities. The consideration
per share received by BioSepra for Additional Shares of BioSepra Common Stock
deemed to have been issued pursuant to Subsection 5(d)(iii) hereof, relating to
Options and Exchangeable Securities, shall be determined by dividing:

                         (x) the total amount, if any, received or receivable by
BioSepra as consideration for the issue of such Options or Exchangeable
Securities, plus the minimum aggregate amount of additional consideration (as
set forth in the instruments relating thereto, without regard to any provision
contained therein for a subsequent adjustment of such consideration) payable to
BioSepra upon the exercise of such Options or the conversion or exchange of such
Exchangeable Securities, or in the case of Options for Exchangeable Securities,
the exercise of such Options for Exchangeable Securities and the conversion or
exchange of such Exchangeable Securities, by

                         (y) the maximum number of shares of BioSepra Common
Stock (as set forth in the instruments relating thereto, without regard to any
provision contained therein for a subsequent adjustment of such number) issuable
upon the exercise of such Options or the conversion or exchange of such
Exchangeable Securities.

          (e) Adjustment for Stock Splits and Combinations. If BioSepra shall at
any time or from time to time after the Original Issue Date effect a subdivision
of the outstanding BioSepra Common Stock, the Exchange Price then in effect
immediately before that subdivision shall be proportionately decreased. If
BioSepra shall at any time or from time to time after the Original Issue Date
combine the outstanding shares of BioSepra Common Stock, the Exchange Price then
in effect immediately before the combination shall be proportionately increased.
Any adjustment under this Section 5(e) shall become effective at the close of
business on the date the subdivision or combination becomes effective.

          (f) Adjustment for Certain Dividends and Distributions. In the event
BioSepra at any time, or from time to time after the Original Issue Date shall
make or issue, or fix a record date for the determination of holders of BioSepra
Common


<PAGE>



Stock entitled to receive, a dividend or other distribution payable in
additional shares of BioSepra Common Stock, then and in each such event the
Exchange Price for the Series B Preferred Stock then in effect shall be
decreased as of the time of such insurance or, in the event such a record date
shall have been fixed, as of the close of business on such record date, by
multiplying the Exchange Price for the Series B Preferred Stock then in effect
by a fraction:

               (x) the numerator of which shall be the total number of shares of
          BioSepra Common Stock issued and outstanding immediately prior to the
          time of such issuance or the close of business on such record date;
          and

               (y) the denominator of which shall be the total number of shares
          of BioSepra Common Stock issued and outstanding immediately prior to
          the time of such issuance or the close of business on such record date
          plus the number of shares of BioSepra Common Stock issuable in payment
          of such dividend or distribution;

provided, however, that if such record date shall have been fixed and such
dividend is not fully paid or if such distribution is not fully made on the date
fixed therefor, the Exchange Price for the Series B Preferred Stock shall be
recomputed accordingly as of the close of business on such record date and
thereafter the Exchange Price for the Series B Preferred Stock shall be adjusted
pursuant to this Section 5(f) as of the time of actual payment of such dividends
or distributions.

          (g) Adjustments for Other Dividends and Distributions. In the event
BioSepra at any time after the Original Issue Date shall make or issue, or fix a
record date for the determination of holders of BioSepra Common stock entitled
to receive, a dividend or other distribution payable in securities of BioSepra
other than shares of BioSepra Common Stock, then and in each such event the
Corporation shall make provision so that the holders of the Series B Preferred
Stock shall receive upon exchange thereof in addition to the number of shares of
BioSepra Common Stock receivable thereupon, the amount of securities of BioSepra
that they would have received had the Series B Preferred Stock been exchanged
for BioSepra Common Stock immediately prior to the date of such event and had
they thereafter, during the period from the date of such event to and including
the Exchange Date, retained such securities receivable by them as aforesaid
during such period, giving application to all adjustments called for during such
period under this Section 5(g) with respect to the rights of the holders of
Series B Preferred Stock.

          (h) Adjustment for Reclassification, Exchange or Substitution. If the
BioSepra Common Stock issuable upon the exchange of the Series B Preferred Stock
shall be changed into the same or a different number of shares of any class or
classes of stock, whether by capital reorganization, reclassification, or
otherwise (other than a subdivision or combination of shares or stock dividend
provided for above, or a reorganization, merger, consolidation, or sale of
assets provided for below), then and


<PAGE>



in each such event the holder of each such share of Series B Preferred Stock
shall have the right thereafter to exchange such share into the kind and amount
of shares of stock and other securities and property receivable upon such
reorganization, reclassification, or other change, by holders of the number of
shares of BioSepra Common Stock for which such shares of Series B Preferred
Stock might have been exchanged immediately prior to such reorganization,
reclassification, or change, all subject to further adjustment as provided
herein.

          (i) Adjustment for Merger or Reorganization, etc. In case of any
consolidation or merger of BioSepra with or into another corporation or the sale
of all or substantially all of the assets of BioSepra to another corporation,
each share of Series B Preferred Stock shall thereafter be exchangeable (or
shall be exchanged for a security which shall be exchangeable) for the kind and
amount of shares of stock or other securities or property to which a holder of
the number of shares of BioSepra Common Stock deliverable upon exchange of such
Series B Preferred Stock would have been entitled upon such consolidation,
merger or sale.

          (j) No Impairment. Without limiting the foregoing, the Corporation
shall use its best efforts to cause BioSepra to carry out all the provisions of
this Section 5 and to cause BioSepra to take all such action as may be necessary
or appropriate in order to protect the Exchange Rights of the holders of Series
B Preferred Stock against impairment.

          (k) Certificate as to Adjustments. Upon the occurrence of each
adjustment or readjustment of the Exchange Price pursuant to this Section 5, the
Corporation at its expense shall promptly compute such adjustment or
readjustment in accordance with the terms hereof and furnish to each holder of
Series B Preferred Stock a certificate setting forth such adjustment or
readjustment and showing in detail the facts upon which such adjustment or
readjustment is based.

          6. Optional Redemption.

          (a) Qualified Merger. At any time after the date on which the
Corporation has entered into a definitive agreement relating to a Qualified
Merger (as defined in Section 2(d) hereof), the Corporation may redeem all, but
not less than all, of the Series B Preferred Stock by paying a redemption price
of $16.00 plus any declared or accrued but unpaid dividends in cash, for each
share of Series B Preferred Stock then redeemed.

          (b) Notice of Section 6(a) Redemption. At least 10 days prior to the
date fixed for any redemption of Series B Preferred Stock pursuant to Section
6(a) hereof, the Corporation shall provide written notice of the redemption of
Series B Preferred Stock to each holder of record of Series B Preferred Stock to
be redeemed, notifying such holder of the election of the Corporation to redeem
such shares, specifying the redemption date, the time and date at which such
holder's Exchange Rights (pursuant to Section 5 hereof), if any, as to such
shares terminate (which shall


<PAGE>



be the close of business on the second full day preceding the redemption date)
and the section of this resolution pursuant to which such redemption is being
made and calling upon such holder to surrender to the Corporation, in the manner
and at the place designated, his or its certificate or certificates representing
the shares to be redeemed (such notice is hereinafter referred to as the
"Redemption Notice"). On or prior to the redemption date, each holder of Series
B Preferred Stock to be redeemed shall surrender his or its certificate or
certificates representing such shares to the Corporation, in the manner and at
the place designated in the Redemption Notice, and thereupon the redemption
price of such shares shall be payable to the order of the person whose name
appears on such certificate or certificates as the owner thereof and each
surrendered certificate or certificates as the owner thereof and each
surrendered certificate shall be cancelled. From and after such redemption date,
unless there shall have been a default in payment of the redemption price, all
rights of the holders of Series B Preferred Stock designated for redemption in
the Redemption Notice as holders of Series B Preferred Stock (except the right
to receive the redemption price, and interest thereon at the rate of 10% per
annum if the redemption price is not paid when due, upon surrender of their
certificate or certificates) shall cease with respect to such shares, and such
shares shall not thereafter be transferred on the books of the Corporation or be
deemed to be outstanding for any purpose whatsoever. Notwithstanding the
foregoing, if said 10% rate of interest is in excess of the rate permitted under
applicable usury laws, said rate shall be reduced to the maximum interest rate
permissible under said usury laws.

          7. Mandatory Redemption.

          (a) March 8, 2000 and Notice Thereof. The Corporation shall, on March
8, 2000, redeem for cash all outstanding shares of Series B Preferred Stock at a
redemption price equal to $16.00 per share, plus any dividends declared or
accrued but unpaid thereon. The notice provisions of Section 6(b) hereof shall
apply to a mandatory redemption pursuant to this Section 7(a).

          (b) Change of Control of BioSepra Inc. If, at any time on or prior to
March 8, 2000, there is a Change of Control (as defined below) of BioSepra, the
Corporation (or any successor in interest to the Corporation) shall, no later
than five business days after such Change of Control, redeem for cash all
outstanding shares of Series B Preferred Stock at a redemption price equal to
one of the following:

               (i) $25.60 per share of Series B Preferred Stock if the BioSepra
Market Capitalization (as defined below) is $120,031,950 or less;

               (ii) $32.00 per share of Series B Preferred Stock if the BioSepra
Market Capitalization is between $120,031,950 and $168,044,730; or

               (iii) $48.00 per share of Series B Preferred Stock if the
BioSepra Market Capitalization is $168,044,730 or more.


<PAGE>



          No declared or accrued but unpaid dividends with respect to the Series
B Preferred Stock shall be paid upon a redemption made pursuant to this Section
7(b).

          A "Change of Control" of BioSepra shall occur or be deemed to have
occurred if any of the following events occur: (A) any "person," as such term is
used in Section 13(d) of the Securities Exchange Act of 1934, as amended (the
"Exchange Act"), (other than the Corporation (or its successor), Beckman
Instruments, Inc. (or its affiliate) or a holder of Series B Preferred Stock (or
an affiliate of such holder), any trustee or other fiduciary holding securities
under an employee benefit plan of BioSepra, or any corporation owned directly or
indirectly by the stockholders of BioSepra in substantially the same proportion
as their ownership of stock of BioSepra) is or becomes the "beneficial owner"
(as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of
securities of BioSepra representing 30% or more of the combined voting power of
BioSepra's then outstanding securities and the Corporation is not or ceases to
be the beneficial owner of securities of BioSepra representing a greater
percentage of such combined voting power than held by such person; (B)
individuals who, as of March 8, 1995, constitute at least a majority of the
Board of Directors of BioSepra (as of the date hereof, the "Incumbent Board")
cease for any reason to constitute at least a majority of the Board of Directors
of BioSepra, provided that any person becoming a director subsequent to March 8,
1995 whose election, or nomination for election by BioSepra's stockholders, was
approved by a vote of at least a majority of the directors then comprising the
Incumbent Board (other than an election or nomination of an individual whose
initial assumption of office is in connection with an actual or threatened
election contest relating to the election of the directors of BioSepra, as such
terms are used in Rule 14a-11 of Regulation 14A under the Exchange Act) shall
be, for purposes hereof, considered as though such person were a member of the
Incumbent Board; (C) the stockholders of BioSepra approve a merger or
consolidation of BioSepra with any other corporation (other than Beckman
Instruments, Inc. (or its affiliate) or a holder of Series B Preferred Stock (or
an affiliate of such holder)), other than (I) a merger or consolidation which
would result in the voting securities of BioSepra outstanding immediately prior
thereto continuing to represent (either by remaining outstanding or by being
converted into voting securities of the surviving entity) more than a majority
of the combined voting power of the voting securities of BioSepra or such
surviving entity outstanding immediately after such merger or consolidation or
(II) a merger or consolidation effected to implement a recapitalization of
BioSepra (or similar transaction) in which no "person" (as hereinabove defined)
acquires more than 30% of the combined voting power of BioSepra's then
outstanding securities; or (D) the stockholders of BioSepra approve a plan of
complete liquidation of BioSepra or an agreement for the sale or disposition by
BioSepra of all or any substantial portion of BioSepra's assets; provided,
however, that unless one or more of the events or conditions specified above
shall have occurred, a change of control of the Corporation pursuant to a
merger, consolidation, sale of stock or assets, or otherwise, without more shall
not be deemed to be a Change of Control of BioSepra.



<PAGE>



          "BioSepra Market Capitalization" shall mean, for the purpose of this
Section 7(b), the product of (A) the BioSepra Share Price (as defined below) and
(B) the number of shares issued and outstanding of BioSepra Common Stock plus
the number of shares issuable upon the exercise, conversion or exchange of
outstanding options, warrants, convertible or exchangeable securities or other
rights to acquire shares of BioSepra Common Stock, whether vested or unvested.

          The "BioSepra Share Price" shall mean the average closing price per
share of BioSepra Common Stock, as reported by the Wall Street Journal (or if
the Wall Street Journal is not then being published, publications of similar
reliability and repute), for the three consecutive trading days immediately
preceding a Change of Control.

          (c) Notice of Section 7(b) Redemption. The Corporation shall provide
written notice of the redemption of the Series B Preferred Stock pursuant to
Section 7(b) hereof to each holder of record of Series B Preferred Stock to be
redeemed as soon as possible, but no less than three calendar days, prior to the
date on which such redemption is to be made. Except as provided in the preceding
sentence, the notice provisions of Section 6(b) hereof shall apply to a
mandatory redemption pursuant to Section 7(b) hereof.

     8. Early Redemption at Election of Holders.

          (a) Upon the written request of the holders of a majority of the then
outstanding shares of Series B Preferred Stock (the "Majority Requesting
Holder(s)") received by the Corporation at least 90 days prior to Monday, March
10, 1997, on March 10, 1997 and on each of the first, second and third
anniversaries thereof (each such date being referred to hereinafter as an "Early
Redemption Date", the Corporation will redeem from each holder of shares of
Series B Preferred Stock, at a price per share as set forth below, subject to
appropriate adjustment in the event of any stock dividend, stock split,
combination or other similar recapitalization affecting such shares (the "Early
Redemption Price"), the following respective portions of the number of shares of
Series B Preferred Stock held by each such holder on the applicable Early
Redemption Date:


<TABLE>
<CAPTION>
                     Portion of the Then Outstanding
                              Shares of
                              Series B Preferred                     Per Share
Redemption Date               Stock to be Redeemed              Redemption Price
- ---------------               --------------------              ----------------
<S>                                   <C>                               <C>   
March 10, 1997                        25%                               $17.98
March 10, 1998                        33-1/3%                           $19.06
March 10, 1999                        50%                               $20.20
March 10, 2000                All then outstanding shares               $21.41
                              of Series B Preferred Stock
</TABLE>



<PAGE>



          No declared or accrued but unpaid dividends with respect to the Series
B Preferred Stock shall be paid upon a redemption made pursuant to this Section
8(a).

          (b) No later than 20 days after receipt of the written notice from the
Majority Requesting Holder(s) pursuant to Section 8(a) hereof, the Corporation
shall provide written notice of the applicable early redemption of Series B
Preferred Stock to each other holder of record of such stock, notifying such
holder of the election of the Majority Requesting Holder(s) to redeem such
shares, the Early Redemption Price and the applicable Early Redemption Date.

          (c) From and after such applicable Early Redemption Date, unless there
shall have been a default in payment of the applicable Early Redemption Price,
all rights of each holder (except the right to receive the applicable Early
Redemption Price, and interest thereon at the rate of 10% per annum if the
applicable Early Redemption Price is not paid when due, upon presentation and
surrender of their certificate or certificates) shall cease with respect to such
shares, and such shares shall not thereafter be transferred on the books of the
Corporation or be deemed to be outstanding for any purpose whatsoever.
Notwithstanding the foregoing, if said 10% rate of interest is in excess of the
rate permitted under applicable usury laws, said rate shall be reduced to the
maximum interest rate permissible under said usury laws.

     9. Deposit of Redemption Price. With respect to any redemption made
pursuant to Sections 6, 7 or 8 hereof, on or prior to the applicable redemption
date, the Corporation shall deposit the redemption price of all applicable
shares of Series B Preferred Stock with a bank or trust company having aggregate
capital and surplus in excess of $500,000,000 as a trust fund for the benefit of
the holders of Series B Preferred Stock, with irrevocable instructions and
authority to the bank or trust company to pay the redemption price for such
shares to their respective holders on or after the redemption date upon receipt
of notification from the Corporation that such holder has surrendered his or its
share certificate to the Corporation. The balance of any monies deposited by the
Corporation pursuant to this Section 9 remaining unclaimed at the expiration of
one year following the redemption date shall thereafter be returned to the
Corporation upon its request expressed in a resolution of its Board of
Directors.

     10. Purchase of Series B Preferred Stock. Nothing herein contained shall
prevent or restrict the purchase by the Corporation, from time to time either at
public or private sale, or the whole or any part of the Series B Preferred Stock
at such price or prices as the holders of Series B Preferred Stock and the
Corporation may mutually agree upon, subject to the provisions of applicable
law.

     11. Funds Legally Available. If the funds of the Corporation legally
available for redemption of Series B Preferred Stock on a redemption date are
insufficient to redeem the shares of Series B Preferred Stock required to be
redeemed


<PAGE>



on such date, those funds which are legally available will be used to redeem the
maximum possible number of such shares of Series B Preferred Stock ratably on
the basis of the number of shares of Series B Preferred Stock which would be
redeemed on such date if the funds of the Corporation legally available therefor
had been sufficient to redeem all shares of Series B Preferred Stock. At any
time thereafter when additional funds of the corporation become legally
available for the redemption of Series B Preferred Stock, such funds will be
used, at the end of the next succeeding fiscal quarter, to redeem the balance of
the shares which the Corporation was theretofore obligated to redeem, ratably on
the basis set forth in the preceding sentence. Without limiting the foregoing,
the Corporation shall be in default when any amounts due to be paid on a
redemption date are not legally available. Holders of such unredeemed shares of
Series B Preferred Stock shall have the right to receive the applicable
redemption price and interest thereon at the rate of 10% per annum for the
period in which the Corporation is obligated to redeem such shares. If said 10%
rate of interest is in excess of the rate permitted under applicable usury laws,
said rate shall be reduced to the maximum interest rate permissible under said
usury laws.

     12. Cancellation and Subsequent Reduction of Authorized Series B Preferred
Stock. Any Series B Preferred Stock redeemed pursuant to this resolution will be
cancelled and will not under any circumstances be reissued, sold or transferred
and the Corporation may from time to time take such appropriate action as may be
necessary to reduce the authorized Series B Preferred Stock accordingly.

     13. Notices. All notices, requests, consents and other communications made
pursuant to this resolution shall be in writing and shall be delivered by hand,
telecopy (if confirmed) or mailed by first-class certified or registered mail,
return receipt requested, postage prepaid. Such notices shall be deemed to have
been made upon dispatch to the appropriate addressee, except for such notices
that are delivered by first-class certified or registered mail, in which case
such notices shall be deemed to have been made upon receipt by the appropriate
addressee. Notice to each holder of Series B Preferred Stock shall be sent in
each case to the telecopy number or address last shown on the records of the
Corporation for such holder. Notice to the Corporation shall be sent in each
case to the telecopy number or address of an appropriate addressee located at
the Corporation's principal office.




<PAGE>



          IN WITNESS WHEREOF, the Corporation has caused its corporate seal to
be affixed hereto and this Certificate to be duly executed by Timothy J.
Barberich, its President, this _____ day of May , 1995.

                                      SEPRACOR INC.,
                                      a Delaware corporation



                                      By:  /s/ Timothy J. Barberich
                                           ---------------------------
                                           Timothy J. Barberich
                                           President




<PAGE>




                            CERTIFICATE OF AMENDMENT

                                       OF

                      RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                                  SEPRACOR INC.


     Sepracor Inc., a corporation organized and existing under and by virtue of
the General Corporation Law of the State of Delaware (the "Corporation"), DOES
HEREBY CERTIFY:

     FIRST: That the Board of Directors of said Corporation, at a meeting duly
called and held on February 14, 1995, as filed with the minutes of the Board of
Directors, duly adopted a resolution pursuant to Section 242 of the General
Corporation Law of the State of Delaware proposing and declaring advisable the
following amendment to the Restated Certificate of Incorporation of the
Corporation:

RESOLVED: That the first paragraph of Article FOURTH of the Corporation's
          Restated Certificate of Incorporation be amended to read in its
          entirety as follows:

     FOURTH: The total number of shares of all classes of stock which the
     Corporation has authority to issue is thirty-six million shares
     (36,000,000) consisting of thirty-five million (35,000,000) shares of
     common stock, $.10 par value per share ("Common Stock"), and one million
     (1,000,000) shares of Preferred Stock, $1.00 par value per share
     ("Preferred Stock").

     SECOND: That the foregoing Amendment to the Corporation's Restated
Certificate of Incorporation was adopted by the holders of a majority of the
outstanding shares of Common Stock and Series A Convertible Preferred Stock at
the


<PAGE>



Corporation's Annual Meeting of Stockholders held on May 17, 1995 pursuant to
notice duly given. 

     IN WITNESS WHEREOF, Sepracor Inc. has caused this Certificate to be signed
by Timothy J. Barberich, its President, and attested by Victor H. Woolley, its
Secretary, this 17th day of May, 1995.

                                               SEPRACOR INC.


                                               By:   /s/ Timothy J. Barberich
                                                    -------------------------
                                                     Timothy J. Barberich
                                               Its:  President

ATTEST:


BY:  /s/ Victor H. Woolley
     -----------------------
     Victor H. Woolley




<PAGE>





                            CERTIFICATE OF AMENDMENT

                                       OF

                      RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                                  SEPRACOR INC.

     Sepracor Inc., a corporation organized and existing under and by virtue of
the General Corporation Law of the State of Delaware (the "Corporation"), DOES
HEREBY CERTIFY:

     FIRST: That the Board of Directors of said Corporation, in a Written Action
in Lieu of Meeting dated as of March 27, 1996, duly adopted a resolution
pursuant to Section 242 of the General Corporation Law of the State of Delaware
("Delaware Law") proposing and declaring advisable the following amendment to
the Restated Certificate of Incorporation of the Corporation:

     RESOLVED: That the first paragraph of Article FOURTH of the Restated
               Certificate of Incorporation, as amended, be amended to read in
               its entirety as follows:

               FOURTH: The total number of shares of all classes of stock which
               the Corporation has authority to issue is forty- one million
               shares (41,000,000) consisting of forty million (40,000,000)
               shares of common stock, $.10 par value per share ("Common
               Stock"), and one million (1,000,000) shares of Preferred Stock,
               $1.00 par value per share ("Preferred Stock").

     SECOND: That the foregoing Amendment to the Corporation's Restated
Certificate of Incorporation, as amended, was adopted by the holders of a
majority of


<PAGE>



the outstanding shares of Common Stock at the Corporation's Annual Meeting of
Stockholders held on May 15, 1996 pursuant to notice duly given.

     IN WITNESS WHEREOF, Sepracor Inc. has caused this Certificate to be signed
by Robert F. Scumaci, its Senior Vice President this 16th day of May, 1996.


                                              SEPRACOR INC.



                                              By: /s/ Robert F. Scumaci
                                                  -----------------------------
                                                  Robert F. Scumaci
                                                  Its: Senior Vice President







<PAGE>



                            CERTIFICATE OF AMENDMENT

                                       OF

                      RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                                  SEPRACOR INC.

     Sepracor Inc., a corporation organized and existing under and by virtue of
the General Corporation Law of the State of Delaware (the "Corporation"), DOES
HEREBY CERTIFY:

     FIRST: That the Board of Directors of said Corporation, at a Meeting duly
called and held on February 26, 1998, as filed with the minutes of the Board of
Directors, duly adopted a resolution pursuant to Section 242 of the General
Corporation Law of the State of Delaware ("Delaware Law") proposing and
declaring advisable the following amendment to the Restated Certificate of
Incorporation, as amended, of the Corporation:

     RESOLVED: That the first paragraph of Article FOURTH of the Restated
               Certificate of Incorporation, as amended, be amended to read in
               its entirety as follows:

               FOURTH: The total number of shares of all classes of stock which
               the Corporation has authority to issue is eighty-one million
               shares (81,000,000) consisting of eighty million (80,000,000)
               shares of Common Stock, $.10 par value per share ("Common
               Stock"), and one million (1,000,000) shares of Preferred Stock,
               $1.00 par value per share ("Preferred Stock").

     SECOND: That the foregoing amendment to the Corporation's Restated
Certificate of Incorporation, as amended, was adopted by the holders of a
majority of


<PAGE>


the outstanding shares of Common Stock at the Corporation's Annual Meeting of
Stockholders held on May 27, 1998 pursuant to notice duly given.

     IN WITNESS WHEREOF, Sepracor Inc. has caused this Certificate to be signed
by Robert F. Scumaci, its Senior Vice President this 3rd day of June, 1998.


                                      SEPRACOR INC.



                                      By: /s/ Robert F. Scumaci
                                          -------------------------------
                                          Robert F. Scumaci
                                          Its: Senior Vice President




                                  [LETTERHEAD]

                               HALE AND DORR LLP
                               COUNSELLORS AT LAW

                  60 STATE STREET, BOSTON, MASSACHUSETTS 02109
                         617-526-6000 o FAX 617-526-5000

                                                                       Exhibit 5
                                                                       ---------

                                  July 6, 1998



Sepracor Inc.
111 Locke Drive
Marlborough, MA 01752

         Re: 1991 Director Stock Option Plan
             -------------------------------
Ladies and Gentlemen:

         We have assisted in the preparation of a Registration Statement on Form
S-8 (the "Registration Statement") to be filed with the Securities and Exchange
Commission relating to 225,000 shares of Common Stock, $.10 par value per share
(the "Shares"), of Sepracor Inc., a Delaware corporation (the "Company"),
issuable under the Company's 1991 Director Stock Option Plan (as amended, the
"Plan").

         We have examined the Certificate of Incorporation, as amended, and the
By-Laws of the Company, and originals, or copies certified to our satisfaction,
of all pertinent records of the meetings of the directors and stockholders of
the Company, the Registration Statement and such other documents relating to the
Company as we have deemed material for the purposes of this opinion.

         In examination of the foregoing documents, we have assumed the
genuineness of all signatures and the authenticity of all documents submitted to
us as originals, the conformity to original documents of all documents submitted
to us as certified or photostatic copies, and the authenticity of the originals
of such latter documents.

         Based on the foregoing, we are of the opinion that the Company has duly
authorized for issuance the shares of its Common Stock covered by the
Registration Statement to be issued under the Plan, as described in the
Registration Statement, and such shares, when issued in accordance with the
terms of the Plan, will be legally issued, fully paid and nonassessable.

<PAGE>

Sepracor Inc.
July 6, 1998
Page 2




         We hereby consent to the filing of this opinion with the Securities and
Exchange Commission in connection with the Registration Statement.

                                              Very truly yours,

                                              /s/ HALE AND DORR LLP

                                              HALE AND DORR LLP




                                                                    Exhibit 23.2
                                                                    ------------

                       CONSENT OF INDEPENDENT ACCOUNTANTS
                       ----------------------------------

         We consent to the incorporation by reference in this Registration
Statement of Sepracor Inc. on Form S-8 relating to the 1991 Director Stock
Option Plan, of our report dated February 19, 1998, except as to the information
in Note W for which the date is March 26, 1998, on our audits of the
consolidated financial statements and financial statement schedule of Sepracor
Inc. 
                                                /s/ PricewaterhouseCoopers LLP

                                                PricewaterhouseCoopers LLP


Boston, Massachusetts
July 6, 1998



                                                                    Exhibit 23.3
                                                                    ------------

                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS
                    -----------------------------------------

     As independent public accountants, we hereby consent to the incorporation
by reference in Sepracor Inc.'s registration statement on Form S-8 of our report
dated January 27, 1998 (except for the matter discussed in Note Q as to which
the date is March 26, 1998) included in BioSepra Inc. and subsidiaries Form
10-K for the year ended December 31, 1997 and to all references to our Firm
included in this registration statement.


                                                     /s/ Arthur Andersen LLP

                                                     Arthur Andersen LLP


Boston, Massachusetts
July 6, 1998



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