SEPRACOR INC /DE/
424B3, 1998-09-24
PHARMACEUTICAL PREPARATIONS
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                                                FILED PURSUANT TO RULE 424(b)(3)
                                                      REGISTRATION NO. 333-51879

PROSPECTUS SUPPLEMENT
(TO PROSPECTUS DATED JUNE 18, 1998)

                                  SEPRACOR INC.
                    ----------------------------------------

               $189,475,000 PRINCIPAL AMOUNT OF 6 1/4% CONVERTIBLE
                        SUBORDINATED DEBENTURES DUE 2005
                  (Interest payable August 15 and February 15)
                    ----------------------------------------

                        4,012,617 Shares of Common Stock
                           ($0.10 par value per share)
                              ---------------------

         The information in this Prospectus Supplement concerning the Selling
Securityholders supplements the statements set forth under the caption "Selling
Securityholders" in the Prospectus. Capitalized items used and not defined
herein shall have the meanings given to them in the Prospectus. The information
set forth under the caption "Selling Securityholders" in the Prospectus is
supplemented as follows:

                             SELLING SECURITYHOLDERS

         The Debentures were originally acquired on February 10, 1998 from the
Company by the Initial Purchasers. The Initial Purchasers advised the Company
that the Initial Purchasers have resold the Debentures in transactions exempt
from the registration requirements of the Securities Act to "qualified
institutional buyers" (as defined in Rule 144A of the Securities Act) and
certain institutional "accredited investors" (as defined in Rule 501(a)(1), (2),
(3), or (7) under the Securities Act). These subsequent purchasers, or their
transferees, pledgees, donees or successors, may from time to time offer and
sell any or all of the Debentures and/or Conversion Shares pursuant to this
Prospectus.

         The Debentures and the Conversion Shares have been registered pursuant
to the Registration Rights Agreement which provides that the Company file a
Registration Statement with regard to the Debentures and the Conversion Shares
within 90 days of the date of original issuance of the Debentures and keep such
Registration Statement effective until the earlier of (i) the sale pursuant to
the Registration Statement of all the securities registered pursuant to the
Registration Rights Agreement thereunder and (ii) the expiration of the holding
period applicable to such securities under Rule 144(k) under the Securities Act
or any successor provision.

         In addition, 12,639 Additional Shares are being registered pursuant to
the Registration Statement for the account of certain securityholders of the
Company. The Selling Securityholders may choose to sell Debentures and/or Shares
from time to time. See "Plan of Distribution."

         Debentures and Conversion Shares. The following table sets forth the
name of each Selling Securityholder who has provided the Company with notice as
of the date of this Prospectus pursuant to the Registration Rights Agreement of
such Selling Securityholder's intent to sell or otherwise dispose of Debentures
and/or Conversion Shares pursuant to the Registration Statement, the principal
amount of Debentures and the number of Conversion Shares which may be sold from
time to time by such Selling Securityholder pursuant to the Registration
Statement and the amount of outstanding


                                        1

<PAGE>



Debentures and Common Stock beneficially owned by such Selling Securityholder
prior to the offering (assuming no conversion of the Debentures). No such
Selling Securityholder nor any of its affiliates has held any position or office
with, been employed by or otherwise has had any material relationship with, the
Company or any of its affiliates during the three years prior to the date of
this Prospectus. Because the Selling Securityholder may offer all or some
portion of the Debentures and Conversion Shares, no estimate can be given as to
the amount or percentage of Debentures or Common Stock that will be held by the
Selling Securityholders upon termination of sales pursuant to this Prospectus.
In addition, the Selling Securityholders identified below may have sold,
transferred or disposed of all or a portion of their Debentures since the date
on which they provided the information regarding their holdings in transactions
exempt from the registration requirements of the Securities Act.


<TABLE>
<CAPTION>
                                                           Amount of                                     Shares of
                                    Amount of              Debentures                                  Common Stock
                                 Debentures that          Owned Before         Shares That May         Owned Before
            Name                   May be Sold              Offering              be Sold(1)             Offering
            ----                 ---------------          ------------         ---------------         ------------

<S>                               <C>                     <C>                     <C>                      <C>
ICI American
Holdings Trust                      $425,000               $425,000                  8,972                     0

Zeneca Holdings Trust                425,000                425,000                  8,972                     0

State of Delaware
PERS                               1,000,000              1,000,000                 21,110                     0

Starvest Fund-
Discretionary                        500,000                500,000                 10,555                     0

State of Oregon/SAIF
Corporation                        4,000,000              4,000,000                 84,443                     0

State of Oregon PERS               4,500,000              4,500,000                 94,998                     0

Nalco Chemical Corp.
Retirement                           225,000                225,000                  4,749                     0

Kapiolani Medical
Center for Women and
Children                             100,000                100,000                  2,111                     0

Hawaiian Airlines
Pension for Salaried
Employees                             15,000                 15,000                    316                     0

Hawaiian Airlines
Pilots' Retirement Plan               70,000                 70,000                  1,477                     0

Hawaiian Airlines
Pension Plan - IAM                    50,000                 50,000                  1,055                     0


                                        2

<PAGE>


Allstate Insurance
Company                                    2,000,000              2,000,000                 42,221                     0

Shepard Investments
International Inc.                        14,875,000             14,875,000                314,023                     0

Silverton International
Fund Limited                               4,250,000              4,250,000                 89,721                     0

Nomura Securities
(Bermuda) Ltd.                            10,000,000             10,000,000                211,108                     0

Paloma Securities
L.L.C.                                     4,475,000              4,475,000                 94,471                     0

Ell & Co., as nominee
for The Northern
Trust Company of
New York                                     580,000                580,000                 12,244                     0

Salkeld & Co., as
nominee for Bankers
Trust Company                                615,000                615,000                 12,983                     0

Bankers Trust
Company                                    1,500,000              1,500,000                 31,666                     0

Bear Stearns Securities
Corp.                                      1,500,000              1,500,000                 31,666                     0

The Income Fund of
America, Inc.                              7,350,000              7,350,000                155,164                     0

The TCW Group, Inc.                       12,315,000             12,315,000                259,980                     0

Deutsche Bank AG                          12,105,000             12,105,000                255,546                     0

Morgan Stanley Dean
Witter                                     2,045,000              2,045,000                 43,171                     0

Colonial Penn Life
Insurance Company                          2,000,000              2,000,000                 42,221                     0

OCM Convertible
Trust                                      3,575,000              3,575,000                 75,471                     0

OCM Convertible
Limited Partnership                          100,000                100,000                  2,111                     0

Delta Air Lines Master
Trust                                      1,025,000              1,025,000                 21,638                     0

State Employees'
Retirement Fund of
the State of Delaware                        840,000                840,000                 17,733                     0


                                        3

<PAGE>




State of Connecticut
Combined Investment
Funds                                      3,210,000              3,210,000                 67,765                     0

Vanguard Convertible
Securities Fund, Inc.                      2,200,000              2,200,000                 46,443                     0

Partner Reinsurance
Company Ltd.                                 280,000                280,000                  5,911                     0

Chrysler Corporation
Master Retirement
Trust                                      2,405,000              2,405,000                 50,771                     0

Raytheon Company
Master Pension Trust                       1,115,000              1,115,000                 23,538                     0

Century National
Insurance Company                            425,000                425,000                  8,972                     0

Chrysler Insurance
Company - Total
Return                                        30,000                 30,000                    633                     0

AAM/Zazove
Institutional Income
Fund L.P.                                  2,500,000              2,500,000                 52,777                     0

Zazove Convertible
Fund L.P.                                    745,000                745,000                 15,727                     0

McMahan Securities
Company L.P.                                 290,000                290,000                  6,122                     0

Stephenson Ventures                          500,000                500,000                 10,555                     0

Delaware State
Employees' Retirement
Fund                                       2,300,000              2,300,000                 48,554                     0

Declaration of Trust
for the Defined Benefit
Plans of ICI American
Holdings, Inc.                             1,030,000              1,030,000                 21,744                     0

Declaration of Trust
for the Defined Benefit
Plans of Zeneca
Holdings Inc.                                700,000                700,000                 14,777                     0

Thermo Electron
Balanced Investment
Fund                                         950,000                950,000                 20,055                     0


                                        4

<PAGE>




Hillside Capital
Incorporated
Corporate Account                            330,000                330,000                  6,966                     0

General Motors
Employees Domestic
Group Trust                               11,630,000             11,630,000                245,519                     0

Summer Hill Global
Partners L.P.                                 80,000                 80,000                  1,688                     0

The J.W. McConnell
Family Foundation                            380,000                380,000                  8,022                     0

TQA Vantage Fund
Ltd.                                       1,000,000              1,000,000                 21,110                     0

TQA Arbitrage Fund,
L.P.                                         750,000                750,000                 15,833                     0

California Public
Employees' Retirement
System                                     4,000,000              4,000,000                 84,443                     0

Millennium Trading
Co., L.P.                                    185,000                185,000                  3,905                     0

Donaldson, Lufkin &
Jenrette Securities
Corp.                                        220,000                220,000                  4,644                     0

Fidelity Financial
Trust:  Fidelity
Convertible Securities
Fund (2)                                   7,815,000              7,815,000                164,981                     0

Fidelity Securities
Fund:  Fidelity OTC
Portfolio (2)                             14,500,000             14,500,000                306,107                     0

MFS Series Trust I-
MFS Convertible
Securities Fund                                2,000                  2,000                     42                     0

MFS Series Trust V-
MFS Total Return
Fund                                       1,998,000              1,998,000                 42,179                     0

Unknown (3)                               35,445,000             35,445,000                748,275                     0
                                     ---------------         --------------               --------                  ----
Total                                   $189,475,000           $189,475,000              3,999,954                     0
- --------------------
</TABLE>


                                        5

<PAGE>


(1)  Assumes conversion of full amount of Debentures held by such holder at the
     initial rate of $47.369 in principal amount of Debentures per share of
     Common Stock.

(2)  Debentures are held in the nominee name of Mag & Co. The entity is either
     an investment company or a portfolio of an investment company registered
     under Section 8 of the Investment Company Act of 1940, as amended, or a
     private investment account advised by Fidelity Management & Research
     Company ("FMR Co."). FMR Co. is a Massachusetts corporation and an
     investment advisor registered under Section 203 of the Investment Advisers
     Act of 1940, as amended, and provides investment advisory services to each
     of such Fidelity entities identified above, and to other registered
     investment companies and to certain other funds which are generally offered
     to a limited group of investors. FMR Co. is a wholly-owned subsidiary of
     FMR Corp. ("FMR"), a Massachusetts corporation. The holdings are as of
     September 2, 1998.

(3)  Certain of the Debentures are currently evidenced by a global Debenture
     which has been deposited with DTC and registered in the name of Cede & Co.
     as DTC's nominee. Therefore, the Company is unable to provide the names of
     the remaining Selling Stockholders.

     Additional Shares. Set forth below are the names of certain other Selling
Securityholders who acquired shares of Common Stock in certain transactions not
related to the sale of Debentures and the maximum number of Additional Shares
that may be sold by each such Selling Securityholder from time to time
hereunder. No such Selling Securityholders nor any of their affiliates has held
any position or office with, been employed by or otherwise have had any material
relationship with, the Company or any of its affiliates during the three years
prior to the date of this Prospectus. The percentage of Common Stock
beneficially owned by each of the Selling Securityholders identified below 
both prior to and after giving effect to the offering being made hereby is
less than 1%.

<TABLE>
<CAPTION>
                               Number of Shares of                                        Number of Shares of
                               Common Stock                 Number of Shares of           Common Stock
                               Beneficially Owned           Common Stock to be            Beneficially Owned
            Name               Prior to this Offering       Offered Hereunder             After this Offering
           ------              -----------------------      -------------------           -------------------
<S>                                             <C>                      <C>                             <C>
Robash Inc.                                     243                      243                             0

Beincke Investment                            1,944                    1,944                             0
Fund L.P.

Theodore H. Ashford                           4,243                      243                         4,000

Bedrock Asset Trust I                         7,778                    7,778                             0

Bankers Trust
Company, as Trustee
of the Hughes Aircraft
Company Retirement
Plans                                        80,539                    2,431                        78,108
</TABLE>



                    The date of this Prospectus Supplement is
                               September 24, 1998



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