SEPRACOR INC /DE/
S-8, 1999-08-11
PHARMACEUTICAL PREPARATIONS
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<PAGE>


    As filed with the Securities and Exchange Commission on August 11, 1999
                              Registration No. 333-
- --------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                                  SEPRACOR INC.
             (Exact Name of Registrant as Specified in Its Charter)

                 DELAWARE                                           22-2536587
      (State or Other Jurisdiction of                           (I.R.S. Employer
      Incorporation or Organization)                         Identification No.)

                111 LOCKE DRIVE, MARLBOROUGH, MASSACHUSETTS 01752
               (Address of Principal Executive Offices) (Zip Code)

                         1991 RESTATED STOCK OPTION PLAN
                            (Full Title of the Plan)

                              MARK G. BORDEN, ESQ.
                                HALE AND DORR LLP
                                 60 STATE STREET
                           BOSTON, MASSACHUSETTS 02109
                     (Name and Address of Agent For Service)

                                 (617) 526-6000
          (Telephone Number, Including Area Code, of Agent For Service)

                         CALCULATION OF REGISTRATION FEE


<TABLE>
<CAPTION>

                                                         Proposed                Proposed
        Title of                                          maximum                maximum
    securities to be            Amount to be          offering price            aggregate               Amount of
       registered                registered              per share            offering price         registration fee
- --------------------       --------------------    --------------------   --------------------    --------------------
<S>                        <C>                     <C>                    <C>          <C>        <C>
Common Stock,              1,500,000
$.10 par value             shares                  $66.75    (1)          $100,125,000 (1)        $27,835
- ----------------------------------------------------------------------------------------------------------------
</TABLE>

(1)      Estimated solely for the purpose of calculating the registration fee,
         and based upon the average of the high and low prices of the Common
         Stock on the Nasdaq National Market on August 6, 1999 in accordance
         with Rules 457(c) and 457(h) of the Securities Act of 1933.
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------


<PAGE>

STATEMENT OF INCORPORATION BY REFERENCE

         Except as otherwise set forth below, this Registration Statement on
Form S-8 incorporates by reference the contents of the Registration Statements
on Form S-8, File Nos. 33-43460, 333-05219 and 333-58557, relating to the
Registrant's 1991 Restated Stock Option Plan, as amended.

PART I.           INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

         The information required by Part I is included in documents sent or
given to participants in the 1991 Restated Stock Option Plan of Sepracor Inc., a
Delaware corporation (the "Registrant"), pursuant to Rule 428(b)(1) under the
Securities Act of 1933, as amended (the "Securities Act").

PART II.          INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

         Item 3.      INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE.

         The Registrant is subject to the informational and reporting
requirements of Sections 13(a), 14, and 15(d) of the Securities and Exchange Act
of 1934, as amended (the "Exchange Act"), and in accordance therewith files
reports, proxy statements and other information with the Securities and Exchange
Commission (the "Commission"). The following documents, which are filed with the
Commission, are incorporated in this Prospectus by reference:

                  (1) The Registrant's latest annual report filed pursuant to
         Section 13(a) or 15(d) of the Exchange Act, or the latest prospectus
         filed pursuant to Rule 424(b) under the Securities Act, that contains
         audited financial statements for the Registrant's latest fiscal year
         for which such statements have been filed.

                  (2) All other reports filed pursuant to Section 13(a) or 15(d)
         of the Exchange Act since the end of the fiscal year covered by the
         documents referred to in (1) above.

                  (3) The description of the Common Stock, par value $.10 per
         share ("Common Stock"), contained in a registration statement filed
         under the Exchange Act, including any amendment or report filed for the
         purpose of updating such description.

         All documents subsequently filed by the Registrant pursuant to Sections
13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a
post-effective amendment which indicates that all shares of Common Stock offered
hereby have been sold or which deregisters all shares of Common Stock then
remaining unsold, shall be deemed to be incorporated by reference herein and to
be part hereof from


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<PAGE>

the date of the filing of such documents.

         Item 4.      DESCRIPTON OF SECURITIES

         Not applicable

         Item 5.      INTERESTS OF NAMED EXPERTS AND COUNSEL

         Not applicable

         Item 6.      INDEMNIFICATION OF DIRECTORS AND OFFICERS

         Section 145 of the Delaware General Corporation Law provides that a
corporation may indemnify any person who was or is a party or is threatened to
be made a party to any threatened, pending or completed action or proceeding,
whether civil, criminal, administrative or investigative, by reason of the fact
that he is or was a director, officer, employee or agent of the corporation or
is or was serving at its request in such capacity in another corporation or
business association, against expenses (including attorneys' fees), judgments,
fines and amounts paid in settlement actually and reasonably incurred by him in
connection with such action, suit or proceeding if he acted in good faith and in
a manner he reasonably believed to be in or not opposed to the best interests of
the corporation, and, with respect to any criminal action or proceeding, had no
reasonable cause to believe his conduct was unlawful.

         Section 102(b)(7) of the Delaware General Corporation Law permits a
corporation to provide in its certificate of incorporation that a director of
the corporation shall not be personally liable to the corporation or its
stockholders for monetary damages for breach of fiduciary duty as a director,
except for liability (i) for any breach of the director's duty of loyalty to the
corporation or its stockholders, (ii) for acts or omissions not in good faith or
which involve intentional misconduct or a knowing violation of law, (iii) under
Section 174 of the Delaware General Corporation Law, or (iv) for any transaction
from which the director derived an improper personal benefit.

         Article NINTH of the Registrant's Restated Certificate of Incorporation
(as amended, the "Certificate of Incorporation") provides that no director of
the Registrant shall be liable for any breach of a fiduciary duty, except to the
extent that the Delaware General Corporation Law prohibits the elimination or
limitation of liability of directors for breach of fiduciary duty.

         Article THIRTEENTH of the Certificate of Incorporation provides that a
director or officer of the Registrant (a) shall be indemnified by the Registrant
against all costs, charges, expenses (including attorneys' fees), judgments,
fines and amounts


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<PAGE>

paid in settlement incurred in connection with any litigation or other legal
proceeding (other than an action by or in the right of the Registrant) brought
against him by virtue of his position as a director or officer of the Registrant
if he acted in good faith and in a manner he reasonably believed to be in, or
not opposed to, the best interests of the Registrant, and, with respect to any
criminal action or proceeding, has no reasonable cause to believe his conduct
was unlawful and (b) shall be indemnified by the Registrant against all costs,
charges and expenses (including attorneys' fees) incurred in connection with any
action by or in the right of the Registrant brought against him by virtue of his
position as a director or officer of the Registrant if he acted in good faith
and in a manner he reasonably believed to be in, or not opposed to, the best
interests of the Registrant, except that no indemnification shall be made with
respect to any such matter as to which such person shall have been adjudged to
be liable to the Registrant, unless a court determines that, despite such
adjudication but in view of all of the circumstances, he is entitled to
indemnification of such expenses. Notwithstanding the foregoing, to the extent
that a director or officer has been successful, on the merits or otherwise,
including, without limitation, the dismissal of an action without prejudice or
the settlement of an action without admission of liability, he is required to be
indemnified by the Registrant against all costs, charges and expenses (including
attorneys' fees) incurred in connection therewith. Expenses shall be advanced to
a director or officer at his request, provided that he undertakes to repay the
amount advanced if it is ultimately determined that the is not entitled to
indemnification for such expenses.

         Indemnification is required to be made unless the Board of Directors or
independent legal counsel determines that the applicable standard of conduct
required for indemnification has not been met. In the event of a determination
by the Board of Directors or independent legal counsel that the director or
officer did not meet the applicable standard of conduct required for
indemnification, or if the Registrant fails to make the applicable standard of
conduct required for indemnification, or if the Registrant fails to make an
indemnification payment within 60 days after such payment is claimed by such
person, such person is permitted to petition the court to make an independent
determination as to whether such person is entitled to indemnification. As a
condition precedent to the right of indemnification, the director or officer
must give the Registrant notice of the action for which indemnity is sought and
the Registrant has the right to participate in such action or assume the defense
thereto.

         Article THIRTEENTH of the Certificate of Incorporation further provides
that the indemnification provided therein is not exclusive, and provides that in
the event that the Delaware General Corporation Law is amended to expand the
indemnification permitted to directors or officers the Registrant must indemnify
those persons to the fullest extent permitted by such law as so amended.

         Item 7.      EXEMPTION FROM REGISTRATION CLAIMED


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<PAGE>

         Not applicable

         Item 8.      EXHIBITS

         The Exhibit Index immediately preceding the exhibits is incorporated
herein by reference.

         Item 9.      UNDERTAKING

         1.       The Registrant hereby undertakes:

                  (a) To file, during any period in which offers or sales are
         being made, a post-effective amendment to this Registration Statement:

                           (i)  To include any prospectus required by Section
         10(a)(3) of the Securities Act;

                           (ii) To reflect in the prospectus any facts or events
         arising after the effective date of the Registration Statement (or the
         most recent post-effective amendment thereof) which, individually or in
         the aggregate, represent a fundamental change in the information set
         forth in the Registration Statement. Notwithstanding the foregoing, any
         increase or decrease in volume of securities offered (if the total
         dollar value of securities offered would not exceed that which was
         registered) and any deviation from the low or high end of the estimated
         maximum offering range may be reflected in the form of prospectus filed
         with the Commission pursuant to Rule 424(b) if, in the aggregate, the
         changes in volume and price represent no more than 20% change in the
         maximum aggregate offering price set forth in the "Calculation of
         Registration Fee" table in the effective Registration Statement; and

                           (iii) To include any material information with
         respect to the plan of distribution not previously disclosed in the
         Registration Statement or any material change to such information in
         the Registration Statement;

         PROVIDED, HOWEVER, that paragraphs (a)(i) and (a)(ii) do not apply if
         the Registration Statement is on Form S-3 or Form S-8, and the
         information required to be included in a post-effective amendment by
         those paragraphs is contained in periodic reports filed by the
         Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act
         that are incorporated by reference in the Registration Statement.

                  (b) That, for the purpose of determining any liability under
         the Securities Act, each such post-effective amendment shall be deemed
         to be a new Registration Statement relating to the securities offered
         therein, and the


                                       5
<PAGE>

         offering of such securities at that time shall be deemed to be the
         initial BONA FIDE offering thereof.

                  (c) To remove from registration by means of a post-effective
         amendment any of the securities being registered which remain unsold at
         the termination of the offering.

         2. The Registrant hereby undertakes that, for the purposes of
determining any liability under the Securities Act, each filing of the
Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange Act (and, where applicable, each filing of an employee benefit plan's
annual report pursuant to Section 15(d) of the Exchange Act) that is
incorporated by reference in the Registration Statement shall be deemed to be a
new Registration Statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be in the initial
BONA FIDE offering thereof.

         3. Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons
of the Registrant pursuant to the foregoing provisions, or otherwise, the
Registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the
Securities Act and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question of whether such
indemnification by it is against public policy as expressed in the Securities
Act and will be governed by the final adjudication of such issue.


                                       6
<PAGE>

                                   SIGNATURES

         Pursuant to the requirements of the Securities Act, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the town of Marlborough, Commonwealth of Massachusetts, on the
11th day of August, 1999.

                                               SEPRACOR INC.


                                               By: /s/ Timothy J. Barberich
                                                  ------------------------------
                                                    Timothy J. Barberich,
                                                    President and
                                                    Chief Executive Officer



                                POWER OF ATTORNEY

         We, the undersigned officers and directors of Sepracor Inc. hereby
severally constitute Timothy J. Barberich, David P. Southwell and Mark G.
Borden, Esq., and each of them singly, our true and lawful attorneys with full
power to them, and each of them singly, to sign for us and in our names in the
capacities indicated below, the Registration Statement on Form S-8 filed
herewith and any and all subsequent amendments to said Registration Statement,
and generally to do all such things in our names and behalf in our capacities as
officers and directors to enable Sepracor Inc. to comply with all requirements
of the Securities and Exchange Commission, hereby ratifying and confirming our
signatures as they may be signed by said attorneys, or any of them, to said
Registration Statement and any and all amendments thereto.



                                       7
<PAGE>


         Pursuant to the requirements of the Securities Act, this Registration
Statement has been signed below by the following persons in the capacities and
on the date indicated.

<TABLE>
<CAPTION>

SIGNATURE                         TITLE                              DATE


<S>                               <C>                                <C>

/s/ Timothy J. Barberich
- ----------------------------      President; Chief Executive         August 11, 1999
Timothy J. Barberich              Officer and Director
                                  (Principal Executive
                                  Officer)

/s/ David P. Southwell
- ----------------------------      Executive Vice President;          August 11, 1999
David P. Southwell                Chief Financial Officer
                                  (Principal Financial Officer)

/s/ Robert F. Scumaci
- ----------------------------      Senior Vice President,             August 11, 1999
Robert F. Scumaci                 Finance and Administration
                                  (Principal Accounting
                                  Officer)

/s/ James G. Andress
- ----------------------------      Director                           August 11, 1999
James G. Andress

/s/ Digby W. Barrios
- ----------------------------      Director                           August 11, 1999
Digby W. Barrios

/s/ Robert J. Cresci
- ----------------------------      Director                           August 11, 1999
Robert J. Cresci

/s/ Keith Mansford
- ----------------------------      Director                           August 11, 1999
Keith Mansford, Ph.D.

</TABLE>


                                       8
<PAGE>

<TABLE>

<S>                               <C>                                <C>
/s/ James F. Mrazek
- ----------------------------      Director                           August 11, 1999
James F. Mrazek

/s/ Alan A. Steigrod
- ----------------------------      Director                           August 11, 1999
Alan A. Steigrod

</TABLE>



                                       9
<PAGE>

                                  EXHIBIT INDEX


Exhibit
Number        Description
- ------        -----------

  4.1(1)      Certificate of Incorporation of the Registrant, as amended
  4.2(2)      By-Laws of the Registrant
  4.3(2)      Specimen Certificate of Common Stock of the Registrant
  5           Opinion of Hale and Dorr LLP
  23.1        Consent of Hale and Dorr LLP (included in Exhibit 5)
  23.2        Consent of PricewaterhouseCoopers LLP
  23.3        Consent of Arthur Andersen LLP
  24          Power of Attorney (included in the signature pages of this
              Registration Statement)







- ------------------
(1)      Incorporated by reference from the Registrant's Registration Statement
         on Form S-8, filed on July 6, 1998, relating to the 1991 Director Stock
         Option Plan.
(2)      Incorporated herein by reference from the Registrant's Registration
         Statement on Form S-1 (File No. 33-41653).




<PAGE>




                                HALE AND DORR LLP
                               Counsellors at Law

                  60 State Street, Boston, Massachusetts 02109

                         617-526-6000 - FAX 617-526-5000
                                                                       EXHIBIT 5





                                 August 11, 1999



Sepracor Inc.
111 Locke Drive
Marlborough, MA 01752

         Re:  1991 RESTATED STOCK OPTION PLAN

Ladies and Gentlemen:

         We have assisted in the preparation of a Registration Statement on Form
S-8 (the "Registration Statement") to be filed with the Securities and Exchange
Commission relating to 1,500,000 shares of Common Stock, $.10 par value per
share (the "Shares"), of Sepracor Inc., a Delaware corporation (the "Company"),
issuable under the Company's 1991 Restated Stock Option Plan (as amended, the
"Plan").

         We have examined the Restated Certificate of Incorporation, as
amended, and the By-Laws of the Company, and originals, or copies certified
to our satisfaction, of all pertinent records of the meetings of the
directors and stockholders of the Company, the Registration Statement and
such other documents relating to the Company as we have deemed material for
the purposes of this opinion.

         In examination of the foregoing documents, we have assumed the
genuineness of all signatures and the authenticity of all documents submitted to
us as originals, the conformity to original documents of all documents submitted
to us as certified or photostatic copies, and the authenticity of the originals
of such latter documents.

         Based on the foregoing, we are of the opinion that the Company has duly
authorized for issuance the shares of its Common Stock covered by the
Registration Statement to be issued under the Plan, as described in the
Registration Statement, and such shares, when issued in accordance with the
terms of the Plan, will be legally issued, fully paid and nonassessable.


<PAGE>




         We hereby consent to the filing of this opinion with the Securities and
Exchange Commission in connection with the Registration Statement.

                                       Very truly yours,

                                       /s/ Hale and Dorr LLP

                                       HALE AND DORR LLP




<PAGE>



                                                                    EXHIBIT 23.2

                       CONSENT OF INDEPENDENT ACCOUNTANTS



         We hereby consent to the incorporation by reference in this
Registration Statement on Form S-8 relating to the 1991 Restated Stock Option
Plan of our report dated February 19, 1999, except as to the information in
Note W for which the date is February 25, 1999, relating to the financial
statements, which appears in the 1998 Annual Report to Shareholders of
Sepracor, Inc., which is incorporated by reference in Sepracor Inc.'s Annual
Report on Form 10-K for the year ended December 31, 1998. We also consent to
the incorporation by reference of our report dated February 19, 1999, except
as to the information in Note W for which the date is February 25, 1999,
relating to the financial statement schedule, which appears in such Annual
Report on Form 10-K.


                                     /s/ PricewaterhouseCoopers LLP

                                     PricewaterhouseCoopers LLP



Boston, Massachusetts
August 11, 1999


<PAGE>



                                                                    EXHIBIT 23.3

                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS


         As independent public accountants, we hereby consent to the
incorporation by reference in the Registration Statement of Sepracor Inc. on
Form S-8 relating to the 1991 Restated Stock Option Plan, of our report dated
February 2, 1999 on the financial statements of BioSphere Medical, Inc.
(formerly BioSepra Inc.) and subsidiaries as of and for the year ended
December 31, 1998, included in Sepracor Inc.'s 1998 Annual Report on Form
10-K/A.

                                     /s/ Arthur Andersen LLP

                                         Arthur Andersen LLP


Boston, Massachusetts
August 10, 1999






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