NEOSE TECHNOLOGIES INC
SC 13D, 1999-07-09
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                 SCHEDULE 13D
                      Under the Securities Exchange of 1934


                            NEOSE TECHNOLOGIES, INC.
                                (Name of Issuer)


                                  COMMON STOCK
                         (Title of Class of Securities)


                                    640522108
                                 (CUSIP Number)


                              MARK H. RACHESKY, M.D.
                           c/o MHR Fund Management LLC
                               40 West 57th Street
                                   33rd Floor
                              New York, N.Y. 10019
                                 (212) 262-0005
                 (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)


                                    Copy to:
                             Craig S. Medwick, Esq.
                               Rogers & Wells LLP
                                200 Park Avenue
                               New York, NY 10166
                                 (212) 878-8000


                                  June 29, 1999
             (Date of Event which Requires Filing of This Statement)




[_]  Check box if the filing person has previously filed a statement on Schedule
     13G to report the  acquisition  which is the subject of this  Schedule 13D,
     and is filing this schedule because of Rule 13d-1(b)(3) or (4).



<PAGE>

CUSIP No. 640522108                    13D                    Page 2


________________________________________________________________________________
1.   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON


     MHR CAPITAL PARTNERS LP
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   SOURCES OF FUNDS


     WC
________________________________________________________________________________
5.   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
     PURSUANT TO ITEM 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6.   CITIZENSHIP OR PLACE OF ORGANIZATION


     DELAWARE
________________________________________________________________________________
               7.   SOLE VOTING POWER

  NUMBER OF         210,526

   UNITS       _________________________________________________________________
               8.   SHARED VOTING POWER
BENEFICIALLY

  OWNED BY          NONE
               _________________________________________________________________
    EACH       9.   SOLE DISPOSITIVE POWER

  REPORTING
                    210,526
   PERSON      _________________________________________________________________
               10.  SHARED DISPOSITIVE POWER
    WITH

                    NONE
________________________________________________________________________________
11.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


     753,390
________________________________________________________________________________
12.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

                                                                      [_]

________________________________________________________________________________
13.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)


     6.6%
________________________________________________________________________________
14.  TYPE OF REPORTING PERSON


     PN
________________________________________________________________________________





<PAGE>

CUSIP No. 640522108                    13D                    Page 3


________________________________________________________________________________
1.   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON


     MRL PARTNERS LP
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   SOURCES OF FUNDS


     WC
________________________________________________________________________________
5.   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
     PURSUANT TO ITEM 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6.   CITIZENSHIP OR PLACE OF ORGANIZATION


     DELAWARE
________________________________________________________________________________
               7.   SOLE VOTING POWER

  NUMBER OF         500,759

   UNITS       _________________________________________________________________
               8.   SHARED VOTING POWER
BENEFICIALLY

  OWNED BY          NONE
               _________________________________________________________________
    EACH       9.   SOLE DISPOSITIVE POWER

  REPORTING
                    500,759
   PERSON      _________________________________________________________________
               10.  SHARED DISPOSITIVE POWER
    WITH

                    NONE
________________________________________________________________________________
11.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


     753,390
________________________________________________________________________________
12.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

                                                                      [_]

________________________________________________________________________________
13.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)


     6.6%
________________________________________________________________________________
14.  TYPE OF REPORTING PERSON


     PN
________________________________________________________________________________



<PAGE>


CUSIP No. 640522108                    13D                    Page 4

________________________________________________________________________________
1.   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON


     OTT LLC
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   SOURCES OF FUNDS


     WC
________________________________________________________________________________
5.   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
     PURSUANT TO ITEM 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6.   CITIZENSHIP OR PLACE OF ORGANIZATION


     DELAWARE
________________________________________________________________________________
               7.   SOLE VOTING POWER

  NUMBER OF         42,105

   UNITS       _________________________________________________________________
               8.   SHARED VOTING POWER
BENEFICIALLY

  OWNED BY          NONE
               _________________________________________________________________
    EACH       9.   SOLE DISPOSITIVE POWER

  REPORTING
                    42,105
   PERSON      _________________________________________________________________
               10.  SHARED DISPOSITIVE POWER
    WITH

                    NONE
________________________________________________________________________________
11.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


     753,390
________________________________________________________________________________
12.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

                                                                      [_]

________________________________________________________________________________
13.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)


     6.6%
________________________________________________________________________________
14.  TYPE OF REPORTING PERSON


     OO
________________________________________________________________________________



<PAGE>

CUSIP No. 640522108                    13D                    Page 5

________________________________________________________________________________
1.   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON


     MHR ADVISORS LLC
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   SOURCES OF FUNDS


     NOT APPLICABLE
________________________________________________________________________________
5.   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
     PURSUANT TO ITEM 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6.   CITIZENSHIP OR PLACE OF ORGANIZATION


     DELAWARE
________________________________________________________________________________
               7.   SOLE VOTING POWER

  NUMBER OF         NONE

   UNITS       _________________________________________________________________
               8.   SHARED VOTING POWER
BENEFICIALLY

  OWNED BY          711,285
               _________________________________________________________________
    EACH       9.   SOLE DISPOSITIVE POWER

  REPORTING
                    NONE
   PERSON      _________________________________________________________________
               10.  SHARED DISPOSITIVE POWER
    WITH

                    711,285
________________________________________________________________________________
11.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


     753,390
________________________________________________________________________________
12.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

                                                                      [_]

________________________________________________________________________________
13.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)


     6.6%
________________________________________________________________________________
14.  TYPE OF REPORTING PERSON


     OO
________________________________________________________________________________



<PAGE>

CUSIP No. 640522108                    13D                    Page 6


________________________________________________________________________________
1.   NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON


     MARK H. RACHESKY, M.D.
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   SOURCES OF FUNDS


     NOT APPLICABLE
________________________________________________________________________________
5.   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
     PURSUANT TO ITEM 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6.   CITIZENSHIP OR PLACE OF ORGANIZATION


     UNITED STATES
________________________________________________________________________________
               7.   SOLE VOTING POWER

  NUMBER OF         NONE

   UNITS       _________________________________________________________________
               8.   SHARED VOTING POWER
BENEFICIALLY

  OWNED BY          753,390
               _________________________________________________________________
    EACH       9.   SOLE DISPOSITIVE POWER

  REPORTING
                    NONE
   PERSON      _________________________________________________________________
               10.  SHARED DISPOSITIVE POWER
    WITH

                    753,390E
________________________________________________________________________________
11.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON


     753,390
________________________________________________________________________________
12.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

                                                                      [_]

________________________________________________________________________________
13.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)


     6.6%
________________________________________________________________________________
14.  TYPE OF REPORTING PERSON


     IN
________________________________________________________________________________


<PAGE>


                                  SCHEDULE 13D
                          FILED PURSUANT TO RULE 13d-1
                   OF THE GENERAL RULES AND REGULATIONS UNDER
                 THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED

Item 1. Security and Issuer.

     This Statement on Schedule 13D (this "Statement")  relates to shares of the
common  stock,  par  value  $0.01  per  share  (the  "Common  Stock"),  of Neose
Technologies, Inc. a Delaware corporation (the "Issuer"). The Issuer's principal
executive offices are located at 102 Witmer Road, Horsham, Pennsylvania 19044.

Item 2. Identity and Background.

     The persons filing this Statement (each, a "Reporting Person" and together,
the "Reporting  Group") are: (i) MHR Capital Partners LP, a limited  partnership
organized  and  existing  under  the  laws of the  State of  Delaware  ("Capital
Partners");  (ii) MRL Partners LP, a limited partnership  organized and existing
under the laws of the State of  Delaware  ("MRL");  (iii) OTT LLC, a  membership
limited  liability company organized and existing under the laws of the State of
Delaware  ("OTT");  (iv) MHR Advisors LLC, the general partner of MHR and MRL, a
membership  limited  liability  company organized and existing under the laws of
the State of Delaware ("Advisors") and (v) Mark H. Rachesky,  M.D., the managing
member of OTT and Advisors,  an individual  citizen of the United  States.  Each
Reporting  Person has an office at 40 West 57th  Street,  33rd Floor,  New York,
N.Y. 10019. The principal  business of each of Capital Partners,  MRL and OTT is
investing for its own account.  The  principal  business of Advisors and Mark H.
Rachesky, M.D. is investment management. During the past five years no Reporting
Person has been convicted in a criminal proceeding (excluding traffic violations
or similar  misdemeanors) or been a party to a civil proceeding of a judicial or
administrative body of competent  jurisdiction which resulted in him or it being
subject to a judgment,  decree or final order enjoining future violations of, or
prohibiting or mandating activities subject to, federal or state securities laws
or finding any violation with respect to such laws.

Item 3. Source and Amount of Funds or Other Consideration.

     The aggregate  amount of funds used by the Reporting  Group to purchase the
753,390 shares of Common Stock was approximately $7,157,205. The Reporting Group
has used its working capital to make such purchase.

Item 4. Purpose of the Transaction.

     The Reporting  Group  acquired the shares of the Common Stock of the Issuer
for investment purposes.

     With respect to plans or proposals that the Reporting Persons may have that
relate to any change in the present  board of  directors  or  management  of the
Issuer,  including  any  plans or  proposals  to  change  the  number or term of
directors  or to fill any  existing  vacancies  on the  board,  please  refer to
Section 19 of the Form of Purchase  Agreement (as  described  below and attached
hereto as Exhibit 7.1).

Item 5. Interest in Securities of the Issuer.

     (a) The Reporting  Persons  acquired shares of Common Stock pursuant to (i)
the Purchase Agreement, dated as of June 25, 1999 between the Issuer and Capital
Partners  (the  "Capital  Partners  Purchase  Agreement");   (ii)  the  Purchase
Agreement,  dated as of June 25,  1999  between  the  Issuer  and MRL (the  "MRL
Purchase

<PAGE>

Agreement"); and (iii) the Purchase Agreement, dated as of June 25, 1999 between
the Issuer and OTT (the "OTT Purchase Agreement"). The Capital Partners Purchase
Agreement,   the  MRL  Purchase   Agreement  and  the  OTT  Purchase   Agreement
(collectively,  the "Purchase  Agreements")  were executed and delivered on June
29, 1999 in  identical  form which is attached  hereto as Exhibit 7.1 and hereby
incorporated herein in its entirety by reference.  Capital Partners, MRL and OTT
are hereinafter referred to each as a "Purchaser." The number of shares acquired
and aggregate  purchase price therefor were hand-written at closing on the first
page  of  each  Purchase  Agreement  as was the  name  of the  Purchaser  on the
signature page thereto.  Pursuant to the Capital  Partners  Purchase  Agreement,
Capital Partners purchased and currently owns 210,526 shares of the Common Stock
of the Issuer  representing  approximately  1.8% of the  shares of Common  Stock
outstanding as of the date hereof.  Pursuant to the MRL Purchase Agreement,  MRL
purchased  and currently  owns 500,759  shares of the Common Stock of the Issuer
representing  approximately 4.4% of the shares of Common Stock outstanding as of
the date  hereof.  Pursuant to the OTT Purchase  Agreement,  OTT  purchased  and
currently  owns  42,105  shares of the Common  Stock of the Issuer  representing
approximately  0.37% of the shares of Common  Stock  outstanding  as of the date
hereof.  Pursuant to Rule 13d-3(c), the Reporting Group and each member thereof,
beneficially  owns an aggregate of 753,390  shares of Common Stock of the Issuer
representing  approximately 6.6% of the shares of Common Stock outstanding as of
the date hereof.  Advisors may be deemed to be a beneficial owner of the 711,285
shares of Common Stock owned by MHR and MRL by reason of its position as general
partner to Capital Partners and MRL. Pursuant to Rule 13d-4,  Advisors disclaims
such beneficial ownership for all other purposes.  Mark H. Rachesky, M.D. may be
deemed to be a  beneficial  owner of (i) the 42,105  shares of Common Stock that
are  beneficially  owned by OTT and (ii) the 711,285 shares of Common Stock that
may be deemed to be beneficially  owned by Advisors by reason of his position as
managing member of both OTT and Advisors.  Pursuant to Rule 13d-4,  Dr. Rachesky
disclaims such beneficial ownership for all other purposes.

     (b) Each of Capital Partners, MRL and OTT has the sole power to vote and to
dispose of the  shares of Common  Stock that it owns.  Advisors  is the  general
partner of Capital  Partners  and MRL (each a limited  partnership).  Therefore,
Advisors may be deemed a beneficial  owner of the 711,285 shares of Common Stock
owned by Capital  Partners and MRL with the power to vote or direct the vote and
the power to  dispose or direct the  disposition  of the shares of Common  Stock
owned by Capital Partners and MRL. Mark H. Rachesky, M.D. is the managing member
of OTT and of Advisors. Therefore. Dr. Rachesky may be deemed a beneficial owner
of the 42,105 shares of Common Stock  beneficially  owned by OTT and the 711,285
shares of Common Stock that may be deemed to be beneficially  owned by Advisors,
with the power to vote or direct the vote and the power to dispose or direct the
disposition of such shares of Common Stock.

     (c) On June 29, pursuant to the Purchase Agreements described in Item 5(a),
the Reporting  Group  purchased an aggregate  total of 753,390  shares of Common
Stock of the Issuer for an aggregate purchase price of approximately $7,157,205.


     (d)-(e) Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to
        Securities of the Issuer.

     The  description  that  follows  of  certain  provisions  of  the  Purchase
Agreements,  the form of which is  attached as  Exhibits  7.1, is not,  and does
purport to be,  complete,  and is qualified in its entirety by reference to such
Exhibits.

     Pursuant to the  Capital  Partners  Purchase  Agreement,  Capital  Partners
purchased  and currently  owns 210,526  shares of the Common Stock of the Issuer
representing  approximately 1.8% of the shares of Common Stock outstanding as of
the date  hereof.  Pursuant to the MRL Purchase  Agreement,  MRL  purchased  and
currently  owns 500,759  shares of the Common  Stock of the Issuer  representing
approximately 4.4% of

<PAGE>

the shares of Common Stock  outstanding  as of the date hereof.  Pursuant to the
OTT Purchase  Agreement,  OTT purchased and currently  owns 42,105 shares of the
Common  Stock of the Issuer  representing  approximately  0.37% of the shares of
Common Stock outstanding as of the date hereof.

     Pursuant  to the  terms  and  subject  to the  conditions  set forth in the
Purchase  Agreements,  the Issuer  granted each  Purchaser  certain  (identical)
registration  rights with respect to the shares of Common Stock issued  pursuant
to the  Purchase  Agreements.  Please refer to Section 7 of the Form of Purchase
Agreement attached hereto as Exhibit 7.1.

     Except as set forth herein,  including  agreements  incorporated  herein by
reference, no contracts, arrangements, understandings or relationships (legal or
otherwise)  between  the  Reporting  Persons  and any other  person  exists with
respect to any  securities of the Issuer,  including but not limited to transfer
or voting of any such securities,  finder's fees, joint ventures, loan or option
arrangements, puts or calls, guarantees of profits, division of profits or loss,
or the giving or withholding of proxies.

Item 7. Material to be Filed as Exhibits.

Exhibit 7.1    Form of Purchase Agreement, dated as of June 25, 1999 between the
               Issuer and a Purchaser.

Exhibit 7.2    Agreement pursuant to Rule 13d-1(f)(1)(iii), filed herewith.

<PAGE>

                                   SIGNATURES

     After  reasonable  inquiry and to the best  knowledge and belief of each of
the undersigned, each of the undersigned hereby certify that the information set
forth in this Statement is true, complete and correct.

Dated: July 9, 1999

                                    MHR CAPITAL PARTNERS LP


                                    By: MHR Advisors LLC, its General Partner


                                        By: /s/ Mark H. Rachesky
                                           -------------------------------
                                        MARK H. RACHESKY, M.D.
                                        Managing Member


                                    MRL PARTNERS LP


                                    By: MHR Advisors LLC, its General Partner


                                        By: /s/ Mark H. Rachesky
                                           -------------------------------
                                        MARK H. RACHESKY, M.D.
                                        Managing Member


                                    OTT LLC


                                    By: /s/ Mark H. Rachesky
                                       -------------------------------
                                    MARK H. RACHESKY, M.D.
                                    Managing Member


                                    MHR ADVISORS LLC


                                    By: /s/ Mark H. Rachesky
                                       -------------------------------
                                    MARK H. RACHESKY, M.D.
                                    Managing Member


                                    MARK H. RACHESKY, M.D.


                                     /s/ Mark H. Rachesky
                                    -----------------------------


<PAGE>

                                  EXHIBIT INDEX

Exhibit No.    Description                                               Page
- -----------    -----------                                               ----

    7.1        Form of Purchase Agreement,  dated as of June 29, 1999
               between the Issuer and a Purchaser.

    7.2        Agreement  pursuant  to Rule  13d-1(f)(1)(iii),  filed
               herewith.



                                                                     EXHIBIT 7.1
                                                      FORM OF PURCHASE AGREEMENT

                               PURCHASE AGREEMENT

     THIS  AGREEMENT  is made as of the 25th day of June,  1999,  between  Neose
Technologies,  Inc. (the "Company"),  a corporation  organized under the laws of
the State of Delaware,  with its principal offices at 102 Witmer Road,  Horsham,
Pennsylvania  19044 and the purchaser whose name and address is set forth on the
signature page hereof (the "Purchaser").

     IN CONSIDERATION of the mutual covenants  contained in this Agreement,  the
Company and the Purchaser, intending to be legally bound, agree as follows:

     SECTION  1.  Authorization  of Sale of  Shares.  Subject  to the  terms and
conditions  of this  Agreement,  the  Company has  authorized  the sale of up to
1,500,000  shares of common  stock  ("Common  Stock"),  par value $.01 per share
(each a "Share," and together the "Shares"), of the Company.

     SECTION 2.  Agreement to Sell and  Purchase the Shares.  At the Closing (as
defined in Section 3), the Company will sell to the Purchaser, and the Purchaser
will buy from the Company, upon the terms and conditions  hereinafter set forth,
the number of Shares shown below at the purchase price shown below:

       Number of Shares                                    Aggregate
       to be Purchased         Price Per Share           Purchase Price
       ---------------         ---------------           --------------


                                    $9.50                      $

The Company is  simultaneously  entering  into a similar  form of this  purchase
agreement with certain other investors (the "Other  Purchasers")  and expects to
complete sales of the Shares to them, although it is understood that there is no
minimum  number of Shares  that are  required  to be sold by the  Company.  (The
Purchaser  and the  Other  Purchasers  are  hereinafter  sometimes  collectively
referred to as the "Purchasers," and this Agreement and the agreements  executed
by the Other Purchasers are hereinafter  sometimes  collectively  referred to as
the "Agreements.")

     SECTION 3.  Delivery of the Shares at the Closing.  The  completion  of the
purchase and sale of the Shares (the "Closing")  shall occur on June 25, 1999 or
such other time as may be agreed  upon by the Company  and each  Purchaser  (the
"Closing Date"). At the Closing,  the Company shall deliver to the Purchaser one
or  more  stock  certificates  for  the  Shares  registered  in the  name of the
Purchaser,  or in such name(s) as designated by the Purchaser,  representing the
number of Shares  set forth in Section 2 above.  The  name(s) in which the stock
certificates  are to be  registered  are  set  forth  in the  Stock  Certificate
Questionnaire attached hereto as part of Appendix I. The Company's obligation to
complete   the   purchase  and  sale  of  the  Shares  and  deliver  such  stock
certificate(s) to the Purchaser at the Closing shall be subject to the following
conditions,  any one or more of which may be waived by the  Company  in its sole
discretion:  (i) receipt by the Company of  immediately  available  funds in the
full amount of the purchase price for the Shares being purchased hereunder; (ii)
completion  of  the  purchases  and  sales  under  the  Agreements   with  Other
Purchasers; and (iii) the accuracy of the representations and warranties made by
the Purchasers and the fulfillment of those undertakings of the Purchasers to be

<PAGE>

fulfilled  prior to the  Closing;  provided,  however,  that in the  event  that
condition (ii) or, with respect to Other Purchasers, condition (iii) is not met,
the  Purchaser  shall have the right,  but not the  obligation,  to purchase the
Shares  which such Other  Purchaser  (the  "Defaulting  Purchaser")  should have
purchased  on the same terms,  and if Other  Purchasers  want to  exercise  this
right,  on a pro rata basis (based on the number of Shares  purchased  hereunder
and under the other purchase  agreements) with any Other  Purchasers  exercising
the right, and if the Purchaser and/or Other Purchasers exercise this right, the
condition shall be deemed to have been met. The Purchaser's obligation to accept
delivery  of such  stock  certificate(s)  and to pay for  the  Shares  evidenced
thereby  shall be  subject  to the  accuracy  in all  material  respects  of the
representations and warranties made by the Company in the Purchase Agreement and
the fulfillment in all material respects of those undertakings of the Company to
be fulfilled prior to Closing.

     SECTION 4.  Representations,  Warranties and Covenants of the Company.  The
Company hereby  represents and warrants to, and covenants with, the Purchaser as
follows:

     4.1.  Organization  and  Qualification.  The Company is a corporation  duly
organized and in good  standing  under the laws of the State of Delaware and has
all requisite corporate power and authority to conduct its business as currently
conducted.  The Company is qualified to do business as a foreign corporation and
is in good standing in each jurisdiction in which the Company conducts business,
except  where the failure to do so would not have a material  adverse  effect on
the business, condition (financial or otherwise) or results of operations of the
Company.

     4.2.  Authorized  and Issued  Capital  Stock.  (a) As of June 10, 1999, the
authorized  capital stock of the Company  consists of (i)  30,000,000  shares of
Common Stock,  of which  9,909,416  shares are  outstanding,  and (ii) 5,000,000
shares of preferred  stock,  $.01 par value per share,  of which 300,000  shares
have been designated  "Series A Junior Preferred  Stock" for potential  issuance
under  the terms of the  Amended  and  Restated  Rights  Agreement,  dated as of
December  3, 1998,  between  the Company  and  American  Stock  Transfer & Trust
Company,  as rights agent,  and no shares are issued and  outstanding  as of the
date hereof.  All of the outstanding  shares of Common Stock were validly issued
and are fully paid and non-assessable shares.

     (b) The Company has  registered  its Common Stock pursuant to Section 12(b)
or 12(g) of the Securities  Exchange Act of 1934, as amended  (together with the
rules and regulations promulgated thereunder, the "Exchange Act") and is in full
compliance with all reporting  requirements of the Exchange Act, and the Company
has maintained all  requirements  for the continued  listing or quotation of its
Common Stock,  and such Common Stock is currently listed or quoted on the Nasdaq
National Market (the "Principal Market").

     4.3.  Due  Execution,  Delivery  and  Performance  of the  Agreements.  The
execution,  delivery and  performance  of the Agreements by the Company (i) have
been duly authorized by all requisite corporate action by the Company,  and (ii)
will not  violate  any law or the Second  Amended and  Restated  Certificate  of
Incorporation  (the "Certificate of  Incorporation") or the Amended and Restated
Bylaws  (the  "Bylaws")  of the  Company,  or  any  provision  of  any  material
indenture,  mortgage,  agreement, contract or other material instrument to which
the  Company  is a party or by which the  Company  or any of its  properties  or
assets is bound as of the date  hereof,  or result in a breach of or  constitute
(upon  notice  or lapse  of time or  both) a  default  under  any such  material
indenture,  mortgage, agreement, contract or other material instrument or result
in the creation or imposition of any lien, security interest,  mortgage, pledge,
charge  or  other  encumbrance,  of any  material  nature  whatsoever,  upon any
properties or assets of the Company.  The Company has no material  subsidiaries.
Upon their execution and delivery,  and assuming the valid execution  thereof by
the respective  Purchasers,  the Agreements  will  constitute  valid and binding
obligations  of the Company,  enforceable  in accordance  with their  respective
terms,  except  as  enforceability  may be  limited  by  applicable  bankruptcy,
insolvency, reorganization,  moratorium or


                                       2
<PAGE>

similar laws affecting  creditors' and contracting parties' rights generally and
except  as  enforceability  may be  subject  to  general  principles  of  equity
(regardless  of whether such  enforceability  is  considered  in a proceeding in
equity or at law) and except as the indemnification and contribution  agreements
of the Company in Section 7.4 hereof may be legally unenforceable.

     4.4. Issuance,  Sale and Delivery of the Shares.  When issued and paid for,
the  Shares to be sold  hereunder  by the  Company  will be  validly  issued and
outstanding,  fully  paid and  non-assessable.  Neither  the sale of the  Shares
pursuant  to, nor the  Company's  performance  of its  obligations  under,  this
Agreement shall (i) result in the creation or imposition of any liens,  charges,
claims  or  other  encumbrances  upon the  Shares  or any of the  assets  of the
Company,  or (ii)  entitle  the  holders  of the  outstanding  Common  Stock  to
preemptive  or other  rights to  subscribe  to or acquire  Common Stock or other
securities of the Company.

     4.5. Exemption from Registration.  Assuming the accuracy of the Purchaser's
representations  and  warranties  set  forth in  Section 5  hereof,  the  offer,
issuance  and sale of the  Shares  pursuant  to this  Agreement  are and will be
exempt  from  the  registration  and  prospectus  delivery  requirements  of the
Securities  Act of 1933,  as amended  (together  with the rules and  regulations
promulgated thereunder, the "Securities Act").

     4.6. Additional  Information.  The Company represents and warrants that the
information  contained  in the  following  documents,  copies of which have been
furnished to the  Purchaser,  was true and correct in all material  respects and
did not contain  any untrue  statement  of a material  fact or omit to state any
material fact necessary to make the statements contained therein in light of the
circumstances  under which they were made, not misleading as of their respective
dates (the "SEC Documents"):

    (i)   the Company's 1998 annual report to stockholders;

    (ii)  the  Company's  annual  report on Form 10-K for the fiscal  year ended
          December 31, 1998 (without exhibits);

    (iii) the  Company's  quarterly  report  on Form  10-Q for the  three  month
          period ended March 31, 1999;

    (iv)  the notice of annual meeting of  stockholders  and proxy statement for
          the Company's 1999 annual meeting of stockholders  held June 15, 1999;
          and

    (v)   all other documents,  if any, filed by the Company with the Securities
          and  Exchange  Commission  (the  "Commission")  since  March 31,  1999
          pursuant to the reporting requirements of the Exchange Act.

     4.7. No Material Change. As of the date hereof,  there has been no material
adverse change in the business, condition (financial or otherwise) or results of
operations of the Company since March 31, 1999.

     4.8.  Legal  Opinion.  Prior to and as a condition to the Closing,  Morgan,
Lewis & Bockius LLP,  counsel to the Company,  will deliver its legal opinion to
the Purchasers as to the valid issuance of the Shares.


                                       3
<PAGE>

     4.9.  Listing of Common  Stock.  The  Company  shall cause the Shares to be
listed on the Nasdaq  National  Market and maintain the listing of the Shares on
each national  securities  exchange or automated  quotation system, if any, upon
which shares of Common Stock are then listed.

     SECTION 5. Representations, Warranties and Covenants of the Purchaser.

     (a) The  Purchaser  acknowledges  that the Shares have not been  registered
under the  Securities  Act or any state  securities  law and may not be offered,
sold, pledged or otherwise  transferred (i) in the absence of such registration,
(ii) unless the Company receives an opinion of counsel reasonably  acceptable to
it that such offer, sale, pledge or transfer is exempt from any registration and
prospectus delivery  requirements of the Securities Act and any applicable state
securities laws or (iii) unless sold pursuant to Rule 144 promulgated  under the
Securities Act ("Rule 144") in accordance with the terms of such rule. Except as
otherwise  permitted by Section 7.3, each  certificate  for the Shares issued at
the Closing or upon direct or indirect  transfer of or in  substitution  thereof
shall be stamped  or  otherwise  imprinted  with a legend in  substantially  the
following form:

     The Shares  represented by this  certificate have not been registered under
     the  Securities  Act of 1933,  as amended,  or under any  applicable  state
     securities laws and may not be offered, sold, pledged or transferred (i) in
     the  absence of such  registration,  (ii)  unless the  Company  receives an
     opinion of counsel, in form,  substance and scope reasonably  acceptable to
     the Company,  that such offer,  sale, pledge or transfer is exempt from any
     registration and prospectus delivery requirements of the Securities Act and
     such applicable state securities laws or (iii) unless sold pursuant to Rule
     144 promulgated under the Securities Act.

     (b) The  Purchaser  represents  and warrants to, and  covenants  with,  the
Company that: (i) the Purchaser, taking into account the personnel and resources
it can  practically  bring to bear on the  purchase  of the Shares  contemplated
hereby,  is  knowledgeable,  sophisticated  and  experienced  in making,  and is
qualified to make,  decisions with respect to  investments in equity  securities
presenting  an  investment  decision  like that  involved in the purchase of the
Shares,  including  investments in equity securities issued by development-state
biotechnology companies; (ii) the Purchaser or its counsel, accountants or other
investment  advisers  have  requested,  received,  reviewed and  considered  all
information  deemed relevant by them in making an informed  decision to purchase
the Shares,  (iii) the Purchaser is acquiring the Shares in the ordinary  course
of its business and for its own account for investment  only and with no present
intention of  distributing  any of the Shares,  nor is there any  arrangement or
understanding  with any other persons regarding the distribution of such Shares;
provided  however,  that such  representation  and  warranty  will not limit the
Purchaser's  right to sell Shares  pursuant  to the  Registration  Statement  or
pursuant  to an  exemption  from the  Securities  Act of 1933,  as amended  (the
"Securities  Act"); (iv) the Purchaser will not, directly or indirectly,  offer,
sell  (including  sell  short),  pledge,  transfer or  otherwise  dispose of (or
solicit any offers to buy,  purchase or  otherwise  acquire or take a pledge of)
any of the Shares except in compliance  with the  Securities  Act, and the rules
and  regulations  promulgated  thereunder;  (v) the  Purchaser  has completed or
caused to be completed the Registration  Statement  Questionnaire  and the Stock
Certificate  Questionnaire,  both  attached  hereto  as  Appendix  I, for use in
preparation  of the  Registration  Statement  and the answers  thereto are true,
correct and complete in all material  respects as of the date hereof and will be
true,  correct and complete in all material respects as of the effective date of
the  Registration  Statement;  (vi) the Purchaser  has, in  connection  with its
decision to purchase  the number of Shares set forth in Section 2 above,  relied
solely upon the SEC  Documents,  the draft plan of  distribution  section of the
Registration  Statement,  and the  representations and warranties of the Company
contained  herein,  as well as any investigation of the Company completed by the
Purchaser or its counsel,  accountants or other investment  advisers;  and (vii)
the  Purchaser  is an  "accredited  investor"  within the meaning of Rule 501 of
Regulation D promulgated under the Securities Act.


                                       4
<PAGE>

     (c) The  Purchaser  agrees  not to make any sale of the  Shares  under  the
Registration  Statement  without  effectively  causing the  prospectus  delivery
requirement  under  the  Securities  Act  to be  satisfied,  and  the  Purchaser
acknowledges  and agrees that such Shares are not  transferable  on the books of
the Company unless the  certificate  submitted to the transfer agent  evidencing
the Shares is accompanied by a separate officer's  certificate:  (i) in the form
of Appendix  II hereto,  (ii)  executed  by an officer  of, or other  authorized
person designated by, the Purchaser, and (iii) to the effect that (A) the Shares
have been sold pursuant to and in accordance with the Registration Statement and
(B) the requirement of delivering a current  prospectus has been satisfied.  The
Purchaser  acknowledges  that there may  occasionally  be times when the Company
must  suspend  the use of the  prospectus  forming  a part  of the  Registration
Statement until such time as an amendment to the Registration Statement has been
filed by the Company and  declared  effective by the  Commission,  or until such
time as the Company has filed an appropriate report with the Commission pursuant
to the  Exchange  Act.  The  Purchaser  agrees  that it will not sell any Shares
during  the  period  commencing  at the  time at which  the  Company  gives  the
Purchaser  notice of the suspension of the use of said  prospectus and ending at
the  time the  Company  gives  the  Purchaser  notice  that  the  Purchaser  may
thereafter  effect sales pursuant to said prospectus.  The Company shall only be
able to suspend the use of said prospectus for periods  aggregating no more than
thirty business days in any twelve month period. The Purchaser further agrees to
notify  promptly  the  Company of the sale of all of its  Shares,  and to notify
promptly the Company in writing of any material  changes in the  information set
forth in the  Registration  Statement  relating to the  Purchaser or its plan of
distribution.

     (d) The Purchaser  further  represents and warrants to, and covenants with,
the Company that (i) the Purchaser has full right, power, authority and capacity
to enter into this  Agreement and to consummate  the  transactions  contemplated
hereby and has taken all necessary  action to authorize the execution,  delivery
and performance of this  Agreement,  and (ii) upon the execution and delivery of
this Agreement,  this Agreement shall constitute a valid and binding  obligation
of  the  Purchaser   enforceable  in  accordance  with  its  terms,   except  as
enforceability   may  be   limited   by   applicable   bankruptcy,   insolvency,
reorganization,  moratorium or similar laws affecting creditors' and contracting
parties' rights generally and except as enforceability may be subject to general
principles of equity (regardless of whether such enforceability is considered in
a  proceeding  in  equity  or at law)  and  except  as the  indemnification  and
contribution  agreements  of the  Purchaser in Section 7.4 hereof may be legally
unenforceable.

     SECTION  6.  Survival  of   Representations,   Warranties  and  Agreements.
Notwithstanding  any  investigation  made by any  party to this  Agreement,  all
covenants,  agreements,  representations  and warranties made by the Company and
the Purchaser herein shall survive the execution of this Agreement, the delivery
to the Purchaser of the Shares being purchased and the payment therefor.

     SECTION 7. Registration of Shares

     7.1. Registration Procedures and Expenses.

     (a)  The Company shall as soon as  practicable,  but in no event later than
          30 days after the  Closing,  prepare  and file with the  Commission  a
          registration  statement on Form S-3 (or if such form is unavailable to
          the  Company,   on  such  other  form  deemed   appropriate   for  the
          registration of the Common Stock by the Commission) (the "Registration
          Statement")  to  register  the  Shares  for  resale by the  Purchasers
          ("Registrable  Securities") in non-underwritten,  market transactions,
          and shall use its best efforts to cause the Registration  Statement to
          become effective as soon as practicable thereafter. The Company shall,
          within


                                       5
<PAGE>

          three business days before filing such Registration Statement, provide
          a draft to the Purchaser and its counsel for review and comment.

     (b)  The Company shall promptly  prepare and file with the Commission  such
          amendments  and  supplements  to the  Registration  Statement  and the
          prospectus  used in  connection  therewith as may be necessary to keep
          such the Registration  Statement effective until the first to occur of
          (i) such date when either all of the Registrable  Securities have been
          sold pursuant  thereto or, by reason of Rule 144(k) of the  Commission
          under the  Securities  Act or any other  rule of similar  effect,  the
          Registrable Securities are no longer required to be registered for the
          sale thereof by the Purchasers in ordinary market transactions without
          imposition of any volume  limitations,  or (ii) the second anniversary
          of the Closing (the "Registration Period");

     (c)  The Company shall  promptly  furnish to the  Purchaser  such number of
          copies of prospectuses and preliminary prospectuses in conformity with
          the requirements of the Securities Act as the Purchaser may reasonably
          request,  in order to facilitate the public sale or other  disposition
          of all or any of the Registrable Securities by the Purchaser;

     (d)  The Company shall promptly file documents  required of the Company for
          normal blue sky clearance for the Registrable  Securities in New York,
          Pennsylvania  and  such  other  states  specified  in  writing  by the
          Purchaser;  provided,  however, that the Company shall not be required
          to (i)  qualify to do business or consent to service of process in any
          jurisdiction  in  which  it is not  now  so  qualified  or has  not so
          consented,  (ii)  subject  itself  to  general  taxation  in any  such
          jurisdiction,  (iii) provide any  undertakings  that cause the Company
          undue  burden or  expense  or (iv) make any  change in its  charter or
          bylaws;

     (e)  The Company shall  promptly  inform the Purchaser  when any stop order
          has been issued with respect to the Registration Statement and use its
          best efforts to promptly cause such stop order to be withdrawn;

     (f)  In the  event  the  Purchasers,  at  their  sole  expense,  engage  an
          underwriter in connection  with the resale of the Shares,  the Company
          will use commercially reasonable efforts to enter into and perform its
          obligations  under an underwriting  agreement,  in usual and customary
          form, with the managing underwriter of such offer;

     (g)  The Company shall notify the Purchasers whose shares are registered on
          a Registration Statement at any time when a prospectus relating to any
          Registrable  Securities  covered by such  Registration  Statement or a
          Company  Registration  Statement is required to be delivered under the
          Securities Act, of the happening of any event as a result of which the
          prospectus included in such registration statement, as then in effect,
          includes an untrue  statement  of a material  fact or omits to state a
          material fact  required to be stated  therein or necessary to make the
          statements  therein not misleading in light of the circumstances  then
          existing and promptly file such  amendments and  supplements as may be
          necessary so that, as thereafter  delivered to such Purchasers of such
          Registrable  Securities,  such prospectus  shall not include an untrue
          statement of a material fact or omit to state a material fact required
          to be stated therein or necessary to make the

                                       6
<PAGE>

          statements  therein not misleading in light of the circumstances  then
          existing  and use its best  efforts to cause each such  amendment  and
          supplement to become effective;

     (h)  In the  event  the  Purchasers,  at  their  sole  expense,  engage  an
          underwriter in connection  with the resale of the Shares,  the Company
          will use commercially  reasonable efforts to furnish at the reasonable
          request  of  the  participating  Purchasers  on  the  date  that  such
          Registrable  Securities are delivered to the  underwriters for sale in
          connection with a registration pursuant to Section 7.1 (i) an opinion,
          dated such date, of the counsel representing the Company, for purposes
          of such registration, in form and substance as is customarily given by
          company counsel to the underwriters in an underwritten public offering
          addressed to the  underwriters,  if any, and to such  Purchasers,  and
          (ii) a letter dated such date, from the independent  certified  public
          accountants  of the Company,  in form and substance as is  customarily
          given by independent  certified public  accountants to underwriters in
          an underwritten public offering,  addressed to the underwriters and to
          such  Purchasers.  In  addition,  if  in  connection  with  a  Company
          Registration  Statement  (as  defined  below)  any  Puchaser  shall be
          required to become a party to an underwriting  agreement,  the Company
          will  provide  the  opinions  and letters set forth in clauses (i) and
          (ii) of the preceding sentence addressed to such Purchasers; and

     (i)  The Company shall bear all expenses in connection  with the procedures
          in  this  Section  7.1  and  the  procedures  in  Section  7.2 and the
          registration of the Shares pursuant to the Registration  Statement and
          the Company Registration  Statement (as defined in Section 7.2), other
          than fees and  expenses,  if any, of counsel or other  advisers to the
          Purchaser or the Other  Purchasers  and any  expenses  relating to the
          sale  of  the  Registrable  Securities  by the  Purchasers  (including
          without  limitation,  broker's  commissions,  discounts or fees of any
          nature and transfer taxes or charges of any nature).

     The Company  understands that the Purchaser disclaims being an underwriter,
but the Purchaser  being deemed an underwriter  shall not relieve the Company of
any obligations it has hereunder.  A questionnaire  related to the  Registration
Statement  to be  completed  by the  Purchaser is attached as Appendix I to this
Agreement.

     7.2  Piggy-back  Registration  Rights.  If at any time  during  the  period
beginning  six months  from the date hereof and prior to the  expiration  of the
Registration  Period,  the Company shall determine to file with the Commission a
registration  statement  relating to an offering  for its own account  under the
1933 Act of any of its equity  securities (other than on Form S-4 or Form S-8 or
their then  equivalents  relating to equity  securities  to be issued  solely in
connection with any  acquisition of any entity or business or equity  securities
issuable in connection  with stock option or other  employee  benefit  plans) (a
"Company Registration Statement"), the Company shall send to each Purchaser that
(together with affiliates  thereof) holds at least 200,000 shares written notice
of such  determination and, if within fifteen (15) days after the effective date
of such notice,  such Purchaser  shall so request in writing,  the Company shall
include in such Company Registration Statement all or any Registrable Securities
such Purchaser requests to be registered, except that if, in connection with any
underwritten  public  offering  for the  account  of the  Company  the  managing
underwriter(s)  thereof  shall  impose a  limitation  on the number of shares of
Common  Stock  which  may be  included  in the  Company  Registration  Statement
because, in such  underwriter(s)'  judgment,  marketing or other factors dictate
such limitation is necessary to facilitate public distribution, then the Company
shall be obligated to include in such Company  Registration


                                       7
<PAGE>

Statement only such limited portion of the Registrable Securities,  if any, with
respect  to which  such  Purchaser  has  requested  inclusion  hereunder  as the
underwriter shall permit. Any exclusion of Registrable  Securities shall be made
pro rata  among the  Purchasers  seeking to include  Registrable  Securities  in
proportion to the number of Registrable Securities sought to be included by such
Purchasers;  provided,  however,  that any exclusion of  Registrable  Securities
shall be made pro rata with  holders  of other  securities  having  the right to
include such securities in the Company Registration Statement other than holders
of  securities  entitled  to  inclusion  of  their  securities  in such  Company
Registration  Statement by reason of demand registration  rights. If an offering
in  connection  with which an Purchaser is entitled to  registration  under this
Section 7.2 is an underwritten  offering,  then each Purchaser whose Registrable
Securities are included in such Company  Registration  Statement  shall,  unless
otherwise agreed by the Company,  offer and sell such Registrable  Securities in
an underwritten offering using the same underwriter or underwriters and, subject
to the provisions of this  Agreement,  on the same terms and conditions as other
shares  of Common  Stock  included  in such  underwritten  offering.  All of the
obligations of the Purchasers  pursuant to this Agreement shall be applicable to
any Company Registration Statement filed pursuant to this Section 7.2. After the
date hereof and prior to the expiration of the Registration  Period, the Company
shall not,  without  the  consent of a majority  of the  holders of  Registrable
Securities,  grant to any holder of securities of the Company  rights similar to
those  granted to the  Purchasers  pursuant to this Section 7.2 which are not in
parity with or junior to the rights granted to the  Purchasers  pursuant to this
Section 7.2.

     7.3.  Transfer of Shares.  The Purchaser agrees that it will not effect any
disposition of the Shares except as contemplated in the  Registration  Statement
or Company Registration  Statement or as otherwise in compliance with applicable
securities laws.

     7.4. Indemnification. For the purpose of this Section 7.4.:

     (a)  the term  "Selling  Stockholder"  shall  include  the  Purchaser,  its
          officers,  directors, and/or trustees and any affiliate or controlling
          person of such Purchaser or any permitted assign hereunder;

     (b)  the term "Registration  Statement" shall include any final prospectus,
          exhibit,  supplement  or  amendment  included  in or  relating  to the
          Registration  Statement  referred  to in  Section  7.1 or the  Company
          Registration Statement referred to in Section 7.2; and

     (c)  the term  "untrue  statement"  shall  include any untrue  statement or
          alleged untrue statement, or any omission or alleged omission to state
          in the  Registration  Statement a material  fact required to be stated
          therein or necessary to make the statements  therein,  in the light of
          the circumstances under which they were made, not misleading.

     The Company agrees to indemnify and hold harmless each Selling  Stockholder
from and  against  any  losses,  claims,  damages or  liabilities  to which such
Selling  Stockholder  may become subject (under the Securities Act or otherwise)
insofar  as  such  losses,   claims,  damages  or  liabilities  (or  actions  or
proceedings  in respect  thereof) arise out of, or are based upon, any breach of
the  representations set forth in Section 4 hereof by the Company, or any untrue
statement of a material fact contained in the Registration  Statement,  or arise
out of any  failure  by the  Company  to  fulfill  any  agreement,  covenant  or
undertaking  contained  in  this  Agreement  or  included  in  the  Registration
Statement,  and the Company  will  reimburse  such Selling  Stockholder  for any
reasonable  legal  or  other  expenses  reasonably  incurred  in  investigating,
defending or preparing to defend any such action, proceeding or claim; provided,
however,  that the  Company  shall not be liable in any such case to the  extent
that such loss, claim,  damage or


                                       8
<PAGE>

liability  arises out of, or is based upon, (i) an untrue  statement made in the
Registration   Statement  in  reliance  upon  and  in  conformity  with  written
information furnished to the Company by or on behalf of such Selling Stockholder
specifically for use in preparation of the  Registration  Statement (which shall
be deemed to include the  information  set forth in the  Registration  Statement
Questionnaire and in the plan of distribution  section of the prospectus),  (ii)
the  failure  of such  Selling  Stockholder  to comply  with the  covenants  and
agreements  contained herein respecting transfer or sale of the Shares, or (iii)
any statement or omission in any Prospectus  that is corrected in any subsequent
Prospectus  that was delivered to the Purchaser  prior to the pertinent  sale or
sales by the Purchaser. The Company shall also not be liable for amounts paid in
settlement  of any  loss,  claim,  damage or  liability  if such  settlement  if
effected  without the prior written consent of the Company,  which consent shall
not be unreasonably withheld.

     The  Purchaser  agrees to indemnify and hold harmless the Company (and each
person, if any, who controls the Company within the meaning of Section 15 of the
Securities Act, each officer of the Company who signs the Registration Statement
and each director of the Company) from and against any losses,  claims,  damages
or  liabilities  to  which  the  Company  (or  any  such  officer,  director  or
controlling  person) may become subject (under the Securities Act or otherwise),
insofar  as  such  losses,   claims,  damages  or  liabilities  (or  actions  or
proceedings  in respect  thereof) arise out of, or are based upon, any breach of
the  representations  set forth in  Section 5 hereof  by the  Purchaser,  or any
failure by the Purchaser to comply with the covenants and  agreements  contained
herein  transfer or sale of the Shares,  or any untrue  statement  of a material
fact contained in the  Registration  Statement if such untrue statement was made
in reliance upon and in conformity with written  information  furnished by or on
behalf of the Purchaser specifically for use in the Registration Statement.  The
Purchaser will  reimburse the Company (or such officer,  director or controlling
person), as the case may be, for any legal or other expenses reasonably incurred
in investigating,  defending or preparing to defend any such action,  proceeding
or claim. The Purchaser  agrees that the information  regarding the Purchaser or
its officers,  directors and affiliates and their intended plan of  distribution
of the Shares set forth in the Registration Statement questionnaire, the form of
which  is  attached  as  Appendix  1,  or  included  from  time  to  time in the
Registration  Statement  (including  without limitation the plan of distribution
section of the Registration Statement) shall be deemed to be written information
furnished to the Company by or on behalf of the Purchaser  specifically  for use
in  preparation of the  Registration  Statement.  The foregoing  indemnification
shall be limited in amount as to each purchaser to the Aggregate  Purchase Price
paid by such purchaser hereunder.

     Promptly after receipt by any indemnified  person of a notice of a claim or
the  beginning  of any  action in  respect  of which  indemnity  is to be sought
against an indemnifying  person  pursuant to this Section 7.4, such  indemnified
person shall notify the  indemnifying  person in writing of such claim or of the
commencement  of  such  action;  provided,  however,  that  any  failure  by  an
indemnified  person to notify  an  indemnifying  person  shall not  relieve  the
indemnifying person from its obligations hereunder except to the extent that the
indemnifying person is prejudiced thereby. Subject to the provisions hereinafter
stated,  in case any such action shall be brought against an indemnified  person
and such indemnifying person shall have been notified thereof, such indemnifying
person  shall be entitled to  participate  therein,  and, to the extent it shall
wish,  to assume and  control  the  defense  thereof,  with  counsel  reasonably
satisfactory  to such  indemnified  person.  After notice from the  indemnifying
person to such indemnified person of its election to assume the defense thereof,
such indemnifying  person shall not be liable to such indemnified person for any
legal expenses  subsequently  incurred by such indemnified  person in connection
with the defense thereof; provided,  however, that if there exists a conflict of
interest  that would  make it  inappropriate,  in the  opinion of counsel to the
indemnifying  person,  for the same  counsel to represent  both the  indemnified
person and such indemnifying  person or any affiliate or associate thereof,  the
indemnified person shall be entitled to retain its own counsel at the expense of
such indemnifying person; provided further, however, that no indemnifying person
shall be responsible for the


                                       9
<PAGE>

fees and expenses of more than one separate counsel for all indemnified  parties
hereunder and under the other Agreements.

     If  the  indemnification   provided  for  in  this  Section  7.4  from  the
indemnifying   person  would  be  applicable  by  its  terms  but  is  otherwise
unavailable,  as  determined  by a  court  of  applicable  jurisdiction,  to  an
indemnified  person  hereunder  in  respect  of  any  losses,  claims,  damages,
liabilities or expenses  referred to herein,  then the indemnifying  person,  in
lieu of indemnifying  such  indemnified  person,  shall contribute to the amount
paid or payable by such indemnified  person as a result of such losses,  claims,
damages, liabilities or expenses in such proportion as is appropriate to reflect
the  relative  fault of the  indemnifying  person  and  indemnified  persons  in
connection  with the actions  which  resulted in such losses,  claims,  damages,
liabilities or expenses, as well as any other relevant equitable considerations.
The relative fault of such indemnifying  person and indemnified persons shall be
determined by reference to, among other things,  whether any action in question,
including any untrue or alleged  untrue  statement of a material  fact, has been
made by, or relates to  information  supplied  by, such  indemnifying  person or
indemnified  persons,  and the parties'  relative intent,  knowledge,  access to
information and  opportunity to correct or prevent such action.  The amount paid
or payable by a party as a result of the losses,  claims,  damages,  liabilities
and  expenses  referred  to above  shall be deemed to  include,  subject  to the
limitations set forth in this Section 7.4, any reasonable legal or other fees or
expenses  reasonably incurred by such party in connection with any investigation
or proceeding.

     The  parties  hereto  agree  that it  would  not be just and  equitable  if
contribution pursuant to this Section 7.4 were determined by pro rata allocation
or by any  other  method  of  allocation  which  does  not take  account  of the
equitable  considerations  referred to in the immediately  preceding  paragraph.
Notwithstanding  the  provisions  of this  Section  7.4, no  Purchaser  shall be
required to contribute any amount in excess of the dollar amount of the proceeds
received  by such  Purchaser  upon the sale of the  Shares,  giving rise to such
contribution  obligation.  No  person  guilty  of  fraudulent  misrepresentation
(within the meaning of Section 11(f) of the Securities Act) shall be entitled to
contribution   from  any  person   who  was  not   guilty  of  such   fraudulent
misrepresentation.

     7.5.  Termination of Conditions and Obligations.  The conditions imposed by
Section 5 or this Section 7 upon the  transferability  of the Shares shall cease
and terminate as to any  particular  number of the Shares when such Shares shall
have been effectively  registered under the Securities Act and sold or otherwise
disposed of in accordance  with the intended  method of disposition set forth in
the  Registration   Statement,  or  at  such  time  as  an  opinion  of  counsel
satisfactory  to the  Company  shall have been  rendered to the effect that such
conditions are not necessary in order to comply with the Securities Act.

     7.6.  Continued  Availability of Information.  So long as the  Registration
Statement is effective covering the resale of Shares owned by the Purchaser, the
Company will furnish to the Purchaser:

     (a)  as  soon  as  practicable  after  available  (but  in the  case of the
          Company's Annual Report to Stockholders, within 120 days after the end
          of each fiscal year of the Company), one copy of (i) its Annual Report
          to   Stockholders   (which  Annual  Report  shall  contain   financial
          statements  audited in accordance with generally  accepted  accounting
          principles  by a firm of certified  public  accountants),  (ii) if not
          included in substance in the Annual Report to Stockholders, its Annual
          Report on Form 10-K, (iii) any quarterly reports to stockholders,  and
          if not included in substance in its quarterly reports to stockholders,
          its  quarterly  reports  on Form  10-Q,  and  (iv) a full  copy of the
          Registration  Statement  (the  foregoing,   in  each  case,  excluding
          exhibits);


                                       10
<PAGE>

     (b)  upon the reasonable request of the Purchaser, all exhibits excluded by
          the parenthetical to subparagraph  (a)(iv) of this Section 7.6 and all
          other information that is made available to shareholders; and

     (c)  upon the reasonable  request of the Purchaser,  an adequate  number of
          copies of the prospectuses to supply to any other party requiring such
          prospectuses;

and the Company,  upon the reasonable  request of the Purchaser,  will meet with
the  Purchaser or a  representative  thereof at the  Company's  headquarters  to
discuss all information  relevant for disclosure in the  Registration  Statement
and will otherwise cooperate with any Purchaser  conducting an investigation for
the purpose of reducing or eliminating  such  Purchaser's  exposure to liability
under the Securities Act,  including the reasonable  production at the Company's
headquarters  of   non-confidential   information  (and,  upon  execution  of  a
confidentiality   agreement   satisfactory   to   the   Company,    confidential
information).

     7.7 Reports  under  Exchange  Act.  With a view to making  available to the
Purchasers the benefits of Rule 144 promulgated under the Securities Act and any
other  rule or  regulation  of the  Commission  that  may at any  time  permit a
Purchaser to sell Registrable Securities to the public without registration, and
with a view to  making  it  possible  for any such  Purchaser  to  register  the
Registrable  Securities  pursuant  to a  registration  on Form S-3,  the Company
agrees to:

          (a)  make and keep  available  public  information,  as understood and
               defined in Rule 144, at all times;

          (b)  file with the Commission in a timely manner all reports and other
               documents  required of the Company under the  Securities  Act and
               the Exchange act; and

          (c)  furnish to a Purchaser  owning any  Registrable  Securities  upon
               reasonable request (i) a written statement by the Company that is
               has complied  with the  reporting  requirements  of Rule 144, the
               Securities  Act and the  Exchange  act, or that it qualifies as a
               registrant whose Registrable Securities may be resold pursuant to
               Form S-3 (at any time after it so  qualified,  (ii) a copy of the
               most recent  annual or  quarterly  report of the Company and such
               other  reports and  documents so filed by the Company,  and (iii)
               such other information as may be reasonably  required in availing
               any Purchaser of Registrable Securities of any rule or regulation
               of  the  Commission   which  permits  the  selling  of  any  such
               Registrable  Securities without  registration or pursuant to such
               form.

     SECTION 8. Broker's  Fees.  Each of the parties  hereto  hereby  represents
that, on the basis of any actions and  agreements by it, there are no brokers or
finders  entitled to  compensation  in connection with the sale of the Shares to
the  Purchaser,  except for the  Company's  obligations  to  Paramount  Capital,
Incorporated which has acted as finder for the Company.

     SECTION 9.  Cooperation  with Resale  Efforts.  Subject to applicable  law,
after the Registration  Statement  pursuant to Section 7.1 is declared effective
by the  Commission,  to the extent  reasonably  requested  by a  Purchaser  that
(together with affiliates  thereof) holds at least 200,000  Shares,  the Company
will, at its own expense,  assist such  Purchaser  with the resale of the Shares
during the Registration Period, including,  without limitation,  the preparation
of reasonably appropriate promotional


                                       11
<PAGE>

materials and the reasonable  participation of executive officers of the Company
in "road shows" and other selling efforts.

     SECTION 10. Expenses.  At the Closing, each party hereto shall bear its own
expenses;  provided,  however, that the Company shall pay the fees, expenses and
disbursements  of counsel to MHR Fund  Management LLC ("MHR") up to an aggregate
maximum of $15,000.

     SECTION  11.   Notices.   All   notices,   requests,   consents  and  other
communications  hereunder  shall be in  writing,  shall be sent by a  nationally
recognized  overnight express courier postage prepaid, and shall be deemed given
one day after being so sent and shall be delivered as addressed as follows:

     (a)  if to the Company, to:

          Neose Technologies, Inc.
          102 Witmer Road
          Horsham, PA 19041
          Attention: Stephen Roth
                Chairman and Chief
                Executive Officer

          with a copy so mailed to:

          Morgan, Lewis & Bockius LLP
          1701 Market Street
          Philadelphia, Pennsylvania 19103-2921
          Attention: David R. King, Esq.

          or to such  other  person at such  other  place as the  Company  shall
          designate to the Purchaser in writing; and

     (b)  if to the  Purchaser,  at its  address as set forth at the end of this
          Agreement,  or at such  other  address or  addresses  as may have been
          furnished to the Company in writing.

     SECTION 12. Entire Agreement; Changes. This Agreement sets forth the entire
agreement of the parties and may not be modified or amended  except  pursuant to
an instrument in writing signed by the Company and the Purchaser.

     SECTION  13.  Headings.  The  headings  of the  various  sections  of  this
Agreement have been inserted for  convenience of reference only and shall not be
deemed to be part of this Agreement.

     SECTION 14. Severability. In case any provision contained in this Agreement
should be  invalid,  illegal or  unenforceable  in any  respect,  the  validity,
legality and enforceability of the remaining  provisions  contained herein shall
not in any way be affected or impaired thereby.

     SECTION  15.  Governing  Law.  THIS  AGREEMENT  SHALL  BE  GOVERNED  BY AND
CONSTRUED  IN  ACCORDANCE  WITH THE  LAWS OF THE  COMMONWEALTH  OF  PENNSYLVANIA
WITHOUT GIVING EFFECT TO CONFLICTS OF LAWS.


                                       12
<PAGE>

     SECTION 16.  Counterparts.  This  Agreement  may be executed in two or more
counterparts, each of which shall constitute an original, but all of which, when
taken together, shall constitute but one instrument,  and shall become effective
when  one or more  counterparts  have  been  signed  by each  party  hereto  and
delivered to the other parties.

     SECTION 17. Assignment.  Prior to the Registration Statement being declared
effective by the  Commission,  the  Purchaser  (or any  permitted  assignee) may
assign its rights under this Agreement to any subsequent holder of any or all of
the Shares who has  purchased at least  50,000  Shares from such  Purchaser  (or
permitted  assignee),  provided that the Company shall have the right to require
any such  holder of any or all of the  Shares to execute a  counterpart  of this
Agreement  and  agree to be  bound  by the  provisions  of this  Agreement  as a
condition to such holder's claim to any rights hereunder.

     SECTION 18. Publicity.

          (a) Without the prior consent of the other party,  neither party shall
     originate any written, oral or electronic publicity,  news release or other
     public  announcement or document  (including  without limitation any filing
     made with the  Commission)  relating to this  Agreement or the existence of
     any  arrangement  between the parties,  except where such  publicity,  news
     release or other  public  announcement  or  document  is  required  by law,
     provided that, in such event, the Company will provide the Purchaser with a
     draft of such  legally  required  publicity,  news  release or other public
     announcement  or document  and consult  with the  Purchaser  in  connection
     therewith prior to its release.

          (b) Without  limiting the  generality  of the  foregoing,  without the
     prior  consent of the other  party,  the Company  shall not  originate  any
     written,  oral or  electronic  publicity,  news  release  or  other  public
     announcement or document (including without limitation any filing made with
     the Commission)  mentioning the name of Purchaser or any of its affiliates,
     or any of their  respective  principals,  partners,  employees,  investors,
     stockholders  or members,  except to the extent  required by law,  provided
     that, in such event, the Company will provide the Purchaser with a draft of
     such legally required publicity,  news release or other public announcement
     or document and consult with the Purchaser in connection therewith prior to
     its release.

          (c) This Section shall survive the  termination  or expiration of this
     Agreement.

     SECTION 19. Board Representation. The Company shall use its best efforts to
cause its Board of  Directors  to  appoint  the  nominee  of MHR to the Board of
Directors and to nominate such nominee for the Board of Directors at each of the
Company's  stockholders'  meetings in which directors are elected for so long as
MHR and its affiliates own at least 200,000 shares of Common Stock.


                                       13
<PAGE>

     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
executed by their duly authorized  representatives  as of the day and year first
above written.

                             NEOSE TECHNOLOGIES, INC.


                             By
                                ---------------------------------------
                                  P. Sherrill Neff
                                  President and Chief Financial Officer

Print or Type:

                             Name of Purchaser
                               (individual or institution):


                             ---------------------------------------

                             Name of individual representing
                               Purchaser (if an institution):


                             ---------------------------------------

                             Title of individual representing
                               Purchaser (if an institution):


                             ---------------------------------------

Signature by:

                             Individual Purchaser or individual
                               representing Purchaser:


                             ---------------------------------------

                             Address:___________________________

                             Telephone:_________________________

                             Fax:_______________________________

                             E-Mail:____________________________


                                       14
<PAGE>

                     SUMMARY INSTRUCTION SHEET FOR PURCHASER

                   (to be read in conjunction with the entire
                        Purchase Agreement which follows)

A.   Complete the following items on BOTH Purchase Agreements:

     1.   Page 13 - Signature:

          (i)  Name of Purchaser (individual or institution)

          (ii) Name of individual representing Purchaser (if an institution)

          (iii) Title of individual representing Purchaser (if an institution)

          (iv) Signature  of  individual  Purchaser or  individual  representing
               Purchaser

     2.   Appendix I - Stock Certificate Questionnaire:

          Provide  the   information   requested   by  the   Stock   Certificate
          Questionnaire.

          Appendix I - Registration Statement Questionnaire:

          Provide  the  information  requested  by  the  Registration  Statement
          Questionnaire.

     3.   Return  BOTH  properly   completed  and  signed  Purchase   Agreements
          including the properly completed Appendix I to:

          Neose Technologies, Inc.
          102 Witmer Road
          Horsham, PA  19044
          ATTN:  A. Brian Davis

B.   Instructions  regarding  the  transfer of funds for the  purchase of Shares
     will be sent to the Purchaser at a later date.

C.   Upon the  resale of the  Shares  by the  Purchaser  after the  Registration
     Statement  covering the Shares is  effective,  as described in the Purchase
     Agreement, the Purchaser:

          (i)  must  deliver a current  prospectus  of the  Company to the buyer
               (prospectuses   must  be   obtained   from  the  Company  at  the
               Purchaser's request); and

          (ii) must send a letter in the form of  Appendix  II to the Company to
               permit the Shares to transfer.

<PAGE>

                                                                      Appendix I
                                                                    (one of two)

                            NEOSE TECHNOLOGIES, INC.
                         STOCK CERTIFICATE QUESTIONNAIRE

Please provide us with the following information:

1.   The exact name that your Shares are
     to be registered in (this is the
     name that will appear on your stock
     certificate(s)). You may use a
     nominee name if appropriate:                      ______________________

2.   The relationship between the
     Purchaser of the Shares and the
     registered holder listed in
     response to item 1 above:                         ______________________

3.   The mailing address of the
     registered holder listed in
     response to item 1 above:                         ______________________


                                                       ______________________

4.   The social security number or tax
     identification number of the
     registered holder listed in
     response to item 1 above:                         ______________________

<PAGE>

                                                                      Appendix I
                                                                    (two of two)

                            NEOSE TECHNOLOGIES, INC.
                      REGISTRATION STATEMENT QUESTIONNAIRE

     In connection with the preparation of the Registration Statement, please
provide us with the following information:

     1. Pursuant to the "Selling Stockholder" section of the Registration
Statement, please state your or your organization's name exactly as it should
appear in the Registration Statement:

     2. Please provide the number of shares that you or your organization will
own beneficially or of record immediately after Closing, including those Shares
purchased by you or your organization pursuant to this Purchase Agreement and
those shares purchased by you or your organization through other transactions
(indicating whether you have sole or shared voting or dispositive power over
such shares as determined under applicable rules of the Securities and Exchange
Commission):

     3. Have you or your organization had any position, office or other material
relationship within the past three years with the Company or its affiliates, or
with Paramount Capital, Inc., other than as disclosed in the Company's proxy
statements for its 1997 or 1998 annual meeting of stockholders?

          |_|  Yes     |_|  No

     If yes, please indicate the nature of any such relationships below:

      -----------------------------------------------------------------

      -----------------------------------------------------------------

      -----------------------------------------------------------------

<PAGE>

                                                                     APPENDIX II

Attention:

                   PURCHASER'S CERTIFICATE OF SUBSEQUENT SALE

     The undersigned, [an officer of, or other person duly authorized by]
___________________________________________________ [fill in official name of
individual or institution] hereby certifies that he/she [said institution] is
the Purchaser of the shares evidenced by the attached certificate, and as such,
sold such shares on _________ [date] pursuant to and in accordance with
registration statement number _________ [fill in the number of or otherwise
identify registration statement] and the requirement of delivering a current
prospectus by the Company has been complied with in connection with such sale.

Print or Type:

      Name of Purchaser
        (individual or
         institution):       ______________________

      Name of individual
        representing
        Purchaser (if an
        institution)         ______________________

      Title of individual
        representing
        Purchaser (if an
        institution):        ______________________

Signature by:

      Individual purchaser
        or individual repre-
        senting purchaser:   ______________________



                                                                     EXHIBIT 7.2

                            AGREEMENT OF JOINT FILING

     Each of MHR Capital Partners LP, MRL Partners LP, OTT LLC, MHR Advisors LLC
and Mark H. Rachesky, M.D. agree that the Statement on Schedule 13D to which
this Agreement is attached as an exhibit, and all future amendments to this
Statement, shall be filed on behalf of each of them. This Agreement is intended
to satisfy the requirements of Rule 13d-1(f)(1)(iii) under the Securities
Exchange Act of 1934, as amended. This Agreement may be executed in any number
of counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument. Dated: July 9, 1999

                                    MHR CAPITAL PARTNERS LP


                                    By: MHR Advisors LLC, its General Partner


                                        By: /s/ Mark H. Rachesky
                                           -------------------------------
                                        MARK H. RACHESKY, M.D.
                                        Managing Member


                                    MLR PARTNERS LP


                                    By: MHR Advisors LLC, its General Partner


                                        By: /s/ Mark H. Rachesky
                                           -------------------------------
                                        MARK H. RACHESKY, M.D.
                                        Managing Member


                                    OTT LLC


                                    By: /s/ Mark H. Rachesky
                                       -------------------------------
                                    MARK H. RACHESKY, M.D.
                                    Managing Member


                                    MHR ADVISORS LLC


                                    By: /s/ Mark H. Rachesky
                                       -------------------------------
                                    MARK H. RACHESKY, M.D.
                                    Managing Member


                                    MARK H. RACHESKY, M.D.


                                     /s/ Mark H. Rachesky
                                    -----------------------------




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