NEOSE TECHNOLOGIES INC
SC 13G/A, 1999-02-16
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                   ------------------------------------------



                                 SCHEDULE 13G/A
                    Under the Securities Exchange Act of 1934
                               (Amendment No. 2)*
                   ------------------------------------------



                            Neose Technologies, Inc.
                    -----------------------------------------
                                 Name of Issuer


                     Common Stock, par value $.01 per share
                   ------------------------------------------
                         (Title of Class of Securities)


                                   640522 10 8
                                   -----------
                                  CUSIP Number


        *The  remainder  of this cover page shall be filled out for a  reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

        The  information  required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise  subject to the  liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however,  see
the Notes to Schedule 13G).






                                        1

<PAGE>

                                  SCHEDULE 13G

CUSIP No.   640522 10 8
- --------------------------------------------------------------------------------
1)      NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
        Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)      CHECK THE APPROPRIATE BOX IF MEMBER OF A GROUP   (a)  |_|      (b)   |_|
- --------------------------------------------------------------------------------
3)      SEC USE ONLY
- --------------------------------------------------------------------------------
4)      CITIZENSHIP OR PLACE OF ORGANIZATION
        United States
- --------------------------------------------------------------------------------
                      5)     SOLE VOTING POWER
                             477,006 /1/
        NUMBER        ----------------------------------------------------------
        OF            6)     SHARED VOTING POWER
        SHARES               32,000 /2/
        BENEFICIALLY  ----------------------------------------------------------
        OWNED BY      7)     SOLE DISPOSITIVE POWER
        EACH                 477,006 /1/
        REPORTING     ----------------------------------------------------------
        PERSON        8)     SHARED DISPOSITIVE POWER
        WITH                 32,000 /2/
- --------------------------------------------------------------------------------
9)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        509,006 /1/
- --------------------------------------------------------------------------------
10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES                                                               [X]
- --------------------------------------------------------------------------------
11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
        5.3%
- --------------------------------------------------------------------------------
12)     TYPE OF REPORTING PERSON
        IN

- --------
        1 Includes non-qualified stock options in the amount of 3,333 shares and
1,423 shares  granted to Dr.  Rosenwald on 6/19/97 and 1/2/98  respectively,  as
well as non-qualified stock options in the amount of 3,333 shares garnted to Dr.
Rosenwald on 6/11/98.

         2 Excludes (i) 75,624  shares of Common Stock owned by Dr.  Rosenwald's
wife and (ii)  30,250  shares of Common  Stock held by Dr.  Rosenwald's  wife as
custodian for Dr.  Rosenwald's  children,  as to which Dr.  Rosenwald  disclaims
beneficial ownership.



                                        2

<PAGE>

Item 1.

        (a)           Name of Issuer:

                      Neose Technologies, Inc. (the "Company")

        (b)           Address of Issuer's Principal Executive Offices:

                      102 Witmer Road
                      Horsham, PA 19044

Item 2.

        (a)           Name of Person Filing:

                      Lindsay A. Rosenwald, M.D. ("Dr. Rosenwald")

        (b)           Address of Principal Business Office or, if None, 
                      Residence:

                      787 Seventh Avenue, 48th Floor
                      New York, N.Y.  10019

        (c)           Citizen:

                      Dr. Rosenwald is a citizen of the United States.

        (d)           Title of Class of Securities:

                      Common Stock, $0.01 par value ("shares").

        (e)           CUSIP#:

                      640522 10 8

Item 3.

                      Not applicable.

Item 4.               Ownership:

                      For  information  concerning the ownership of Common Stock
                      of the Company by Dr. Rosenwald, see Items 5 through 9 and
                      11 of the cover page to this  schedule  13G and  footnotes
                      thereto.



                                        3

<PAGE>

Item 5.               Ownership of Five Percent or Less of a Class:

                      Not applicable.

Item 6.               Ownership  of More than Five  Percent on Behalf of Another
                      Person:

                      Not applicable.

Item 7.               Identification  and Classification of the Subsidiary Which
                      Acquired  the  Security  Being  Reported  On By the Parent
                      Holding Company:

                      Not applicable.

Item 8.               Identification and Classification of Members of the Group:

                      Not applicable.

Item 9.               Notice of Dissolution of Group:

                      Not applicable.

Item 10.              Certification:

                      Not applicable.



                                    SIGNATURE

        After  reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


Dated:  February 12, 1999
         New York, New York                    /s/ Lindsay A. Rosenwald, M.D. 
                                              ----------------------------------
                                              Lindsay A. Rosenwald, M.D.



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