ANERGEN INC
DEF 14A, 1996-05-24
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                        SCHEDULE 14A INFORMATION
            PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE
                    SECURITIES EXCHANGE ACT OF 1934
                     (Amendment No. ______________)


Filed by the Registrant    /X/
Filed by a party other than the Registrant   / /

Check the appropriate box:
/ /  Preliminary proxy statement
/ /  Confidential, for use of the Commission only (as permitted by
     Rule 14a-6(e)(2))
/x/  Definitive proxy statement
/ /  Definitive additional materials
/ /  Soliciting material pursuant to Sec. 240.14a-11(c) or Sec. 240.14a-12

                                 Anergen, Inc.
            ------------------------------------------------
            (Name of Registrant as Specified in Its Charter)

                                 Anergen, Inc.
  ------------------------------------------------------------------------
  (Name of Person(s) Filing Proxy Statement, if other than the Registrant)


Payment of filing fee (Check the appropriate box):

/X/  $125 per Exchange Act Rules 0-11(c)(1)(ii), 14a-6(i)(1), 14a-6(i)(2)
     or Item 22(a)(2) or Schedule 14A

/ /  $500 per each party to the controversy pursuant to Exchange Act Rule
     14a-6(i)(3).

/ /  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.


(1)  Title of each class of securities to which transactions applies:

- ----------------------------------------------------------------------------

(2)  Aggregate number of securities to which transactions applies:

- ----------------------------------------------------------------------------

(3)  Per unit price or other underlying value of transaction computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing
fee is calculated and state how it was determined):

- ----------------------------------------------------------------------------

(4)  Proposed maximum aggregate value of transaction:

- ----------------------------------------------------------------------------

(5)  Total fee paid:

- ----------------------------------------------------------------------------

/X/  Fee paid previously with preliminary materials.
/ /  Check box if any part of the fee is offset as provided by Exchange Act
     Rule 0-11(a)(2) and identify the filing for which the offsetting fee
     was paid previously.  Identify the previous filing by registration
     statement number, or the Form or Schedule and the date of its filing.

(1)  Amount previously paid:
     $125.00
- ----------------------------------------------------------------------------

(2)  Form, Schedule or Registration Statement No.:

- ----------------------------------------------------------------------------

(3)  Filing party:

- ----------------------------------------------------------------------------

(4)  Date filed:

- ----------------------------------------------------------------------------


<PAGE>


                                  ANERGEN, INC.

                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS

                           To be held on June 26, 1996

TO THE SHAREHOLDERS:

         NOTICE IS HEREBY  GIVEN that the  Annual  Meeting  of  Shareholders  of
Anergen, Inc. (the "Company") will be held on Wednesday,  June 26, 1996 at 10:00
a.m., local time, at the Company's offices at 301 Penobscot Drive, Redwood City,
California 94063 for the following purposes:

         1. To elect  seven  directors  to serve  for one year and  until  their
successors are duly elected.

         2. To approve the adoption of the 1995 Director Option Plan and reserve
200,000 shares for issuance thereunder.

         3. To  approve  an  amendment  to the  Company's  1991  Employee  Stock
Purchase  Plan  increasing  the number of shares of Common  Stock  reserved  for
issuance by 100,000 shares.

         4. To  confirm  the  appointment  of Ernst & Young  LLP as  independent
auditors for the fiscal year ending December 31, 1996.

         5. To  transact  such other  business as may  properly  come before the
meeting or any adjournment thereof.

         Only shareholders of record at the close of business on May 6, 1996 are
entitled to notice of and to vote at the meeting.

         All shareholders are cordially invited to attend the meeting in person.
However, to assure your representation at the meeting, you are urged to sign and
return  the  enclosed  proxy as  promptly  as  possible  in the  postage-prepaid
envelope  enclosed for that purpose.  Any shareholder  attending the meeting may
vote in person even if he has returned a proxy.

                                    By order of the Board of Directors



                                    John W. Fara
                                    President and Chief Executive Officer




Redwood City, California
May 24, 1996

<PAGE>
                                  ANERGEN, INC.

                            PROXY STATEMENT FOR 1996
                         ANNUAL MEETING OF SHAREHOLDERS


                 INFORMATION CONCERNING SOLICITATION AND VOTING


General

         The enclosed  Proxy is solicited on behalf of the Board of Directors of
Anergen,  Inc. (the  "Company") for use at the Annual Meeting of Shareholders to
be held on  Wednesday,  June 26,  1996,  at 10:00 a.m.,  local  time,  or at any
adjournment  thereof,  for the purposes set forth herein and in the accompanying
Notice of Annual Meeting of Shareholders. The Annual Meeting will be held at the
Company's offices at 301 Penobscot Drive, Redwood City, California 94063.

         These proxy solicitation materials were mailed on or about May 24, 1996
to all shareholders entitled to vote at the meeting.

Record Date and Principal Share Ownership

         Shareholders  of record at the  close of  business  on May 6, 1996 (the
"Record Date") are entitled to notice of the meeting and to vote at the meeting.
The Company has only one class of stock outstanding  designated as Common Stock.
At the Record Date,  15,063,180 shares of the Company's Common Stock were issued
and outstanding and held of record by  approximately  382  shareholders and were
beneficially owned by over 400 shareholders.

         The  following  table  sets forth  certain  information  regarding  the
beneficial  ownership as of April 30, 1996 of the  Company's  Common Stock as to
(i) each person who is known to the Company to  beneficially  own more than five
percent of the outstanding shares of its Common Stock, (ii) each director, (iii)
each executive  officer named in the Summary  Compensation  Table below and (iv)
all directors and executive officers as a group:


                                          No. of Shares
                                           Beneficially
                 Name (1)                    Owned              Percentage (2)
- -------------------------------------------------------------------------------


Warburg, Pincus Ventures, L.P.(3).........       4,878,049          32.4%
     466 Lexington Avenue
     New York, NY  10017

Warburg, Pincus & Co.(4)..................       4,878,049          32.4%
     466 Lexington Avenue
     New York, NY  10017


<PAGE>
<TABLE>
<CAPTION>

                                                                                   No. of Shares
                                                                                    Beneficially
                                 Name (1)                                              Owned               Percentage (2)
- ---------------------------------------------------------------------------------------------------------------------------

<S>                                                                                   <C>                        <C>  
International Biotechnology Trust PLC......................................           2,439,024                  16.2%
     Five Arrows House
     St. Swithin's Lane
     London, EC4N 8NR
     England

Novo Nordisk A/S...........................................................           1,219,745                   8.1%
     Novo Alle
     2880 Basgvaerd
     Denmark

John W. Fara, Ph.D.(5).....................................................             347,212                   2.3%

John W. Varian(6)..........................................................             100,350                    *

Jeffrey Winkelhake, Ph.D.(7)...............................................              64,349                    *

Bruce L.A. Carter, Ph.D.(8)................................................           1,219,745                   8.1%

Harden M. McConnell, Ph.D.(9)..............................................              37,776                    *

Harry H. Penner, Jr.(10)...................................................              22,502                    *

James E. Thomas(11)........................................................           4,878,049                  32.4%

Nicholas J. Lowcock(12)....................................................                   0                    --

Nicole Vitullo(13).........................................................                   0                    --

All directors and officers as a group (9 persons)(14)......................           6,669,983                  43.4%
<FN>
- ----------------
*        Represents less than 1% of the outstanding Common Stock.

(1)      The persons named in the table, to the Company's  knowledge,  have sole
         voting and investment  power with respect to all shares of Common Stock
         shown as beneficially owned by them, subject to community property laws
         where  applicable  and  the  information  contained  in  the  footnotes
         hereunder.

(2)      Applicable  percentage  of ownership is based on  15,063,180  shares of
         Common Stock outstanding as of April 30, 1996, together with applicable
         options and warrants held by such stockholder.  Beneficial ownership is
         determined in accordance  with the rules of the Securities and Exchange
         Commission,  and includes  voting and investment  power with respect to
         shares. Shares of Common Stock subject to options exercisable within 60
         days of April  30,  1996  are  deemed  outstanding  for  computing  the
         percentage  ownership of the person  holding such options,  but are not
         deemed outstanding for computing the percentage  ownership of any other
         person.

                                       -2-

<PAGE>

(3)      The sole general partner of Warburg, Pincus Ventures, L.P. ("Ventures")
         is Warburg, Pincus & Co., a New York general partnership ("WP"). Lionel
         I.  Pincus is the  managing  partner of WP and may be deemed to control
         it. E.M.  Warburg,  Pincus & Company,  a New York  general  partnership
         ("E.M.  Warburg"),  manages  Ventures.  WP  has a 15%  interest  in the
         profits of Ventures as the general partner, and also owns approximately
         1.5% of the limited partnership interests in Ventures.

(4)      Represents  shares held by  Ventures.  As the sole  general  partner of
         Ventures (as  described in footnote 3 above),  WP may be deemed to be a
         beneficial owner (within the meaning of Rule 13d-3 under the Securities
         Exchange Act of 1934) of the shares held by Ventures.

(5)      Includes 146,342 shares subject to options  exercisable  within 60 days
         of April 30, 1996.

(6)      Includes 81,571 shares subject to options exercisable within 60 days of
         April 30, 1996.

(7)      Includes 63,142 shares subject to options exercisable within 60 days of
         April 30, 1996.

(8)      Includes 1,219,745 shares held by Novo Nordisk A/S, of which Dr. Carter
         is an executive officer.  Dr. Carter disclaims  beneficial ownership of
         these shares.

(9)      Includes 14,376 shares subject to options exercisable within 60 days of
         April 30, 1996.

(10)     Includes 17,502 shares subject to options exercisable within 60 days of
         April 30, 1996.

(11)     Represents  shares  held by  Ventures.  Mr.  Thomas,  a director of the
         Company, is a Managing Director of E.M. Warburg,  Pincus & Co., Inc., a
         wholly-owned  subsidiary of WP ("EMW"), and a general partner of WP and
         E.M.  Warburg.  As such,  Mr.  Thomas may be deemed to have an indirect
         pecuniary  interest  (within  the  meaning  of  Rule  16a-1  under  the
         Securities  Exchange  Act of 1934) in an  indeterminate  portion of the
         shares  beneficially  owned by Ventures  and WP. Mr.  Thomas  disclaims
         beneficial  ownership of these shares  within the meaning of Rule 13d-3
         under the Securities Exchange Act of 1934.

(12)     Does not include  shares held by Ventures.  Mr.  Lowcock is employed by
         EMW and is a director of the Company.  Mr. Lowcock disclaims beneficial
         ownership of the shares held by Ventures and WP.

(13)     Does not include shares held by International  Biotechnology Trust PLC.
         Ms. Vitullo,  a director of the Company,  is an employee of Rothschild,
         Inc., a corporation affiliated with Rothschild Asset Management,  Ltd.,
         investment  manager  for  International  Biotechnology  Trust PLC.  Ms.
         Vitullo disclaims  beneficial  ownership of the shares of International
         Biotechnology Trust PLC.

(14)     Includes 322,933 shares subject to options  exercisable  within 60 days
         of April 30, 1996.  Reflects the shares of Ventures of which Mr. Thomas
         may be  deemed  to have an  indirect  pecuniary  interest  (within  the
         meaning of Rule 16a-1 of the  Securities  Exchange Act of 1934) and the
         shares of Novo Nordisk A/S of which Dr. Carter is an executive officer.
         Does not reflect  beneficial  ownership of Mr.  Lowcock of Ventures and
         Ms. Vitullo of  International  Biotechnology  Trust PLC who do not have
         beneficial ownership of the shares of such entities, respectively.
</FN>
</TABLE>

Revocability of Proxies

         Any proxy  given  pursuant to this  solicitation  may be revoked by the
person  giving it at any time before its use by  delivering  to the Secretary of
the Company a written  notice of revocation  or a duly executed  proxy bearing a
later date or by attending the meeting and voting in person.

Voting and Solicitation

         Each  shareholder  is entitled  to one vote for each share  held.  Each
shareholder may vote on the proposals  described herein by proxy or by attending
the meeting and voting in person.  Shareholders  may not cumulate their votes in
the election of directors.  The security represented by proxy will be voted, and
when a choice is specified by a shareholder  in the proxy,  the security will be
voted in accordance with that choice.

                                       -3-
<PAGE>

         This  solicitation  of proxies is made by the Company,  and all related
costs will be borne by the  Company.  In  addition,  the Company  may  reimburse
brokerage firms and other persons  representing  beneficial owners of shares for
their expenses in forwarding  solicitation  material to such beneficial  owners.
Original  solicitation  of proxies  by mail may be  supplemented  by  telephone,
telegraph or personal  solicitations by directors,  officers or employees of the
Company. No additional compensation will be paid for any such services.

Deadline for Receipt of Shareholder Proposals

         Proposals  of  shareholders  of the  Company  that are  intended  to be
presented  by  such  shareholders  at  the  Company's  1997  Annual  Meeting  of
Shareholders  must have been  received by the Company no later than  January 24,
1997 in order that they may be considered  for inclusion in the proxy  statement
and form of proxy relating to that meeting.

Vote Required

         In order to be validly  approved  by the  shareholders,  each  proposal
described  herein must be approved by the affirmative  vote of a majority of the
shares  represented  and voting at the meeting at which a quorum is  present.  A
majority  of shares  entitled  to vote,  in person or by proxy,  constitute  the
number  of  shares  necessary  for a quorum  for any  meeting  of  shareholders.
Abstentions for any particular  proposal are counted for purposes of determining
the presence or absence of a quorum. Abstentions and shares held by brokers that
are present but not voted because the brokers were  prohibited  from  exercising
discretionary  authority ("broker non-votes") will be counted as present for the
purpose of determining if a quorum is present, but will not otherwise be counted
as voting for or against a proposal.

                                       -4-
<PAGE>

                                 PROPOSAL NO. 1
                              ELECTION OF DIRECTORS


Nominees

         A board of seven (7)  directors is to be elected at the Annual  Meeting
of Shareholders.  Unless otherwise  instructed,  the proxy holders will vote the
proxies received by them for the Company's nominees named below, all of whom are
presently directors of the Company. In the event that any nominee of the Company
is unable or declines  to serve as a director at the time of the Annual  Meeting
of  Shareholders,  the  proxies  will be  voted  for any  nominee  who  shall be
designated  by the present  Board of Directors  to fill the  vacancy.  It is not
expected that any nominee will be unable or will decline to serve as a director,
however,  pursuant to an agreement  regarding his  retirement  from the Company,
John W. Fara,  Ph.D.  will  transition  during 1996 from full-time  service as a
director and as President,  Chief  Executive  Officer and Secretary to part-time
employment.  At the time of  transition,  Dr. Fara will resign as President  and
Chief  Executive  Officer and  Secretary and from the Board of Directors and the
Board will appoint a new  President  and Chief  Executive  Officer who will also
serve as a  director.  See  "Employment  Contracts,  Termination  and  Change of
Control  Arrangements."  In the event that additional  persons are nominated for
election as directors,  the proxy holders intend to vote all proxies received by
them in such a manner as will  assure the  election  of as many of the  nominees
listed  below as possible,  and in such event the specific  nominees to be voted
for will be determined by the proxy  holders.  The term of office of each person
elected  as  a  director  will  continue   until  the  next  Annual  Meeting  of
Shareholders or until a successor has been elected.
<TABLE>

         The nominees, and certain information about them are set forth below:
<CAPTION>

                                                                                                     Director
      Name of Nominee                         Age             Position(s)                             Since
- --------------------------------------------------------------------------------------------------------------
<S>                                            <C>      <C>                                            <C> 
John W. Fara, Ph.D...........................  53       President, Chief Executive                     1990
                                                        Officer, Secretary and Director

Bruce L. A. Carter, Ph.D.....................  52       Director                                       1994

Nicholas J. Lowcock..........................  32       Director                                       1995

Harden M. McConnell, Ph.D....................  67       Director                                       1989

Harry H. Penner, Jr..........................  50       Director                                       1993

James E. Thomas..............................  35       Director                                       1995

Nicole Vitullo...............................  39       Director                                       1995

</TABLE>

         John W. Fara,  Ph.D.,  joined  Anergen as  President,  Chief  Executive
Officer and a director  in February  1990.  He also serves as  Secretary  of the
Company and was Treasurer prior to August 1991. During the year prior to joining
the Company, Dr. Fara was President of Prototek,  Inc., a biotechnology  company
in Dublin,  California.  Prior to that, he was Director of Biomedical  Research,
and then Vice  President  of  Business  Development,  during ten years with Alza
Corporation,  a  therapeutic  systems  company.  Dr. Fara  received his Ph.D. in
physiology from the University of California at Los Angeles.

                                       -5-
<PAGE>

         Bruce L. A. Carter,  Ph.D.,  was appointed a director of the Company in
February 1994. Since 1994 Dr. Carter has been Corporate Executive Vice President
and  Chief  Scientific   Officer  of  Novo  Nordisk  A/S  ("Novo  Nordisk"),   a
pharmaceutical and bio-industrial  company.  From 1988 to 1995 Dr. Carter served
as president of ZymoGenetics, Inc., a biotechnology company that is a subsidiary
of Novo Nordisk, and has served as Chairman since 1994. Dr. Carter was nominated
to the  Board of  Directors  in  accordance  with  rights  held by Novo  Nordisk
pursuant to an equity agreement  described below under  "Compensation  Committee
Interlocks and Insider Participation."

         Nicholas J.  Lowcock  was  appointed a director of the Company in April
1995.  Since August of 1994 he has been an Associate of E.M.  Warburg,  Pincus &
Co., Inc., a specialized  financial  services firm.  Prior to August,  1994, Mr.
Lowcock was a  consultant  with The Boston  Consulting  Group.  Mr.  Lowcock was
nominated  to the Board of  Directors  in  accordance  with  rights held by E.M.
Warburg,  Pincus & Co., Inc.  pursuant to an equity  agreement  described  below
under "Certain Transactions and Reports."

         Harden M.  McConnell,  Ph.D.,  has been a director of the Company since
May 1989. Dr. McConnell has been a Professor of Chemistry at Stanford University
since 1964 and became  Chairman of the  Department  of Chemistry in 1989.  He is
also a member of the Company's Scientific Advisory Board.

         Harry H. Penner,  Jr. was  appointed  director of the Company in August
1993. Since December of 1993 he has been President/CEO of Neurogen  Corporation,
a neuropharmaceutical company. From 1985 to December 1993, he was Executive Vice
President of Novo Nordisk and,  beginning in 1988,  President of Novo Nordisk of
North America, a subsidiary of Novo Nordisk.

         James E.  Thomas was  appointed  director of the Company in April 1995.
Since  1989 he has  been  employed  by  E.M.  Warburg,  Pincus  & Co.,  Inc.,  a
specialized  financial  services  firm,  where he  currently  serves as Managing
Director.  Prior to 1989,  Mr.  Thomas was a Vice  President  of  Goldman  Sachs
International  in London.  Mr. Thomas was nominated to the Board of Directors in
accordance with rights held by E.M.  Warburg,  Pincus & Co., Inc. pursuant to an
equity agreement  described below under "Certain  Transactions and Reports." Mr.
Thomas is also a  director  of  Celtrix  Pharmaceuticals,  Inc.,  Menley & James
Laboratories, Inc. and a number of privately held companies.

         Nicole Vitullo was appointed director of the Company in April 1995. Ms.
Vitullo is an  Investment  Advisor for  Rothschild  Asset  Management,  Ltd.,  a
manager of two publicly traded  biotechnology funds,  Biotechnology  Investments
Limited and International  Biotechnology  Trust PLC. Prior to joining Rothschild
in 1992,  Ms.  Vitullo was a Director of Corporate  Communications  and Investor
Relations at Cephalon,  Inc., a neuropharmaceutical  company. Prior to 1992, Ms.
Vitullo was Manager of Healthcare Investments for Eastman Kodak, Co. Ms. Vitullo
was  nominated  to the Board of  Directors  in  accordance  with  rights held by
International  Biotechnology Trust PLC pursuant to an equity agreement described
below under "Certain  Transactions  and Reports." Ms. Vitullo is also a director
of Cytel Corporation.

         There are no family relationships among the directors of the Company.

                                       -6-
<PAGE>

Board Meetings and Committees

         The Board of Directors  held a total of nine meetings  during 1995. The
Audit Committee held two meetings during 1995. The  Compensation  Committee held
two  meetings  during  1995.  Each  director  attended at least 75% of the Board
meetings  (except Dr. Carter who was absent for six out of nine  meetings)  and,
where applicable, the Committee meetings held during 1995.

         The Board of Directors  has a  Compensation  Committee  (consisting  of
Messrs.  Penner, Thomas and Ms. Vitullo) that makes  recommendations  concerning
salaries and  incentive  compensation  for employees of the Company and an Audit
Committee (consisting of Dr. Carter, Mr. Lowcock and Dr. McConnell) that reviews
the results and scope of the audit and other services  provided by the Company's
independent auditors.  The Board of Directors has no nominating committee or any
other committee performing a similar function.


Compensation Committee Interlocks and Insider Participation

         At various  times during fiscal year 1995,  the  following  individuals
(none of whom was or had been an officer of the Company) served on the Company's
Compensation Committee: Samuel Urcis, Dr. McConnell, Dr. Carter, Mr. Penner, Mr.
Thomas and Ms. Vitullo. In March, 1995, Mr. Urcis resigned from the Board and in
April,  1995, the Board appointed Mr. Thomas to the Compensation  Committee.  In
April,  1995, the Board appointed Ms. Vitullo to the  Compensation  Committee to
replace Dr. Carter who was appointed to the Audit Committee.

         Novo  Nordisk has certain  rights  under a  collaborative  research and
development  agreement  which it entered  into with the Company in August  1993.
Novo Nordisk also made an equity investment in the Company pursuant to an equity
agreement with the Company in August 1993. Under the collaborative  research and
development agreement, Novo Nordisk will make milestone payments and support the
Company's multiple sclerosis (MS), myasthenia gravis (MG), and insulin dependent
diabetes research and development programs. In exchange,  Novo Nordisk will have
world-wide rights to products developed under the agreement, including rights to
commercialize  these  products.  Anergen has retained  rights of co-promotion in
North  America  for  therapeutics  in MS and MG. The  research  and  development
agreement   provides  that  both  companies  will  contribute  to  manufacturing
processes  and upon  product  commercialization,  Anergen is to receive  royalty
payments from Novo Nordisk based on product sales. Novo Nordisk had the right to
terminate its obligations  under the research and development  agreement after a
36-month  period ending in August 1996,  but in March,  1996 it agreed to extend
the  agreement  by an  additional  two  year  period.  Under  the  research  and
development   agreement,   the  Company  recorded   revenues  for  research  and
development of $3.0 and $2.3 million in 1995 and 1994,  respectively.  Under the
equity  agreement,  Novo Nordisk  purchased  1,219,745  shares of the  Company's
Common Stock for $8,000,000,  with certain rights to obtain additional shares in
the  future.  Also under the equity  agreement,  Novo  Nordisk  has the right to
designate  one nominee to the Board of Directors.  Bruce L. A. Carter,  Ph.D. is
currently nominated pursuant to this right.

                                       -7-
<PAGE>

Executive Officers

         The executive officers of the Company are listed below:


            Name                      Age          Position
            ----                      ---          --------
John W. Fara, Ph.D................    53     President, Chief Executive
                                             Officer, Secretary and Director
John W. Varian....................    36     Vice President, Finance and
                                             Chief Financial Officer
Jeffrey L. Winkelhake, Ph.D.......    51     Vice President, Pharmaceutical
                                             Development

         Dr.  Fara's  background  is  summarized  under  "Election of Directors"
above.

         John W. Varian joined the Company as Vice President,  Finance and Chief
Financial Officer in August 1991. Prior to joining the Company,  and since 1987,
Mr.  Varian  was a Senior  Manager  with  Ernst & Young  LLP.  Mr.  Varian  is a
certified  public   accountant  and  received  his  BBA  from  Western  Michigan
University.

         Jeffrey L. Winkelhake,  Ph.D., joined the Company in April 1993 as Vice
President,  Pharmaceutical  Development.  Prior  to  joining  the  Company,  Dr.
Winkelhake  served for three years as Director  of Program  Management  at Cytel
Corporation,  a  biotechnology  company.  Prior to that,  he served for over six
years as Director of  Pharmacology  at Cetus  Corporation,  also a biotechnology
company. Dr. Winkelhake received his Ph.D. in Immunochemistry/Pharmacology  from
the University of Illinois.

         There are no family  relationships  among the executive officers of the
Company.

Certain Transactions and Reports

         On March 10, 1995 the Company signed a Common Stock Purchase  Agreement
(the  "Agreement")  with  Warburg,   Pincus  Ventures,   L.P.   ("Warburg")  and
International  Biotechnology Trust PLC ("IBT") (collectively,  the "Purchasers")
to purchase 7,317,073 shares of Common Stock for approximately $15 million.  The
new shares were priced at the average closing bid price for the Company's Common
Stock  over a 30 day  trading  period.  This  transaction  was  approved  by the
Company's  shareholders and was completed on April 13, 1995. The Purchasers have
the right at any time after  thirty  (30)  months from April 13, 1995 to request
the Company to effect a registration of at least 30% of the aggregate  number of
shares  held  by the  requesting  Purchaser  or  any  lesser  percentage  if the
aggregate net offering price would exceed  $1,000,000.  The Purchasers also have
the right to have their shares  included in a registration by the Company of its
securities  for its own account or the account of any of its  shareholders.  The
Purchasers  have certain  rights of  representation  on the  Company's  Board of
Directors based on certain  minimum levels of ownership of the Company's  Common
Stock. Under the Agreement, the Company is currently obligated to include in the
slate of nominees  recommended  by the Board of Directors and management at each
election of directors two candidates selected by Warburg, one candidate selected
by IBT and one  candidate  as mutually  agreed to by IBT and  Warburg.  Upon the
closing of this  transaction,  the Board of Directors  appointed to the Board to
fill vacancies two new members representing Warburg, Mr. Nicholas J. Lowcock and
Mr. James E. Thomas,  and one new member  representing  IBT, Ms. Nicole Vitullo.
These three  individuals have been nominated to the Board in connection with the
current election of directors, and it is expected that during the current fiscal
year,

                                       -8-
<PAGE>

IBT and  Warburg  will  identify  an  appropriate  industry  representative  for
nomination  to the Board  pursuant to their right to  designate  such  candidate
under the Agreement.

         In March  1996,  the Company and Novo  Nordisk  agreed to expand  their
collaborative research and development agreement to establish certain milestones
for products developed under the agreement targeting insulin dependent diabetes.
The  parties  also  agreed to extend the term of the  research  and  development
agreement to August, 1998.

                                       -9-
<PAGE>

                             EMPLOYEE BENEFIT PLANS

         The  following is a brief  summary of plans in effect during the fiscal
year ended  December 31, 1995 under which  officers,  directors and employees of
the Company received  benefits.  The closing price of the Company's Common Stock
reported on the NASDAQ National Market on the Record Date was $3.4375 per share.

401(k) Plan

         In January of 1992 the Company adopted a tax-qualified employee savings
and  retirement  plan (the "401(k)  Plan"),  which  generally  covers all of the
Company's  full-time  employees who have attained age 21. Pursuant to the 401(k)
Plan,  employees  may  elect to defer  up to 20% of their  current  compensation
(subject to certain statutorily prescribed limits,  including an annual limit of
$9,240 in 1995).  These deferred amounts are contributed to the 401(k) Plan. The
401(k) Plan  permits,  but does not  require,  additional  matching  and Company
contributions on behalf of participants. Since the Plan's inception, the Company
has contributed an amount equal to 50% of each participant's contribution for up
to 4% of their  eligible  compensation.  The 401(k)  Plan is intended to qualify
under  Sections  401(k)  and 401(a) of the  Internal  Revenue  Code of 1986,  as
amended (the "Code").  Contributions  to such a qualified plan are deductible to
the Company  when made and neither the  contributions  nor the income  earned on
those contributions is taxable to participants until withdrawn.  All 401(k) Plan
contributions  are  credited to  separate  accounts  maintained  in trust by two
individual trustees. Contributions are invested, at the participant's direction,
in one or more of the  investment  funds  available  under the 401(k) Plan.  All
account  balances  are  adjusted at least  annually  to reflect  the  investment
earnings and losses of the trust fund.  Each  participant is fully vested in his
or her salary deferral accounts under the 401(k) Plan. Distributions may be made
from a participant's  account pursuant to the 401(k) Plan's hardship  withdrawal
provisions as well as upon a participant's termination of employment, disability
or  attainment of age 59-1/2.  Distributions  will be in the form of a lump sum,
installment payments or an annuity, in the participant's discretion. Federal tax
laws limit the amount that may be added to a participant's  accounts for any one
year under a qualified plan such as the 401(k) Plan to the lesser of (i) $30,000
or  (ii)  25%  of  the  participant's   compensation  (net  of  salary  deferral
contributions) for the year.

1991 Employee Stock Purchase Plan

         The Company's 1991 Employee  Stock Purchase Plan (the "Purchase  Plan")
is intended to qualify  under  Section 423 of the Code.  The  Purchase  Plan was
amended by the Board in March 1996 to  increase  the number of shares  available
for issuance  thereunder.  A total of 250,000 shares  (including the addition of
100,000  shares in March 1996 -- see  Proposal  Three for  proposed  addition of
100,000  shares) of Common Stock are  reserved  for issuance  under the Purchase
Plan. Under the Purchase Plan, the Company  withholds a specified  percentage of
each salary payment to participating  employees over certain  offering  periods.
Unless  the Board of  Directors  or its  committee  determines  otherwise,  each
offering period runs for 24 months and is divided into four consecutive purchase
periods of six months each.

         The price at which stock is purchased  under the Purchase Plan is equal
to 85% of the fair  market  value of the  Common  Stock on the  first day of the
applicable  offering  period (net initial public  offering price received by the
Company  for the  first  offering  period)  or the  last  day of the  applicable
purchase  period,  whichever is lower. To the extent permitted by Rule 16b-3, if
the purchase  price of the Common  Stock at the end of a purchase  period in any
offering  period  is lower  than the  purchase  price at the  beginning  of that
offering period, then all participants in that offering period are automatically
withdrawn from that offering

                                      -10-
<PAGE>

period  immediately  after  the  exercise  of their  options  and  automatically
re-enrolled in the immediately following offering period.

         As of December 31, 1995, a total of 101,971 shares of Common Stock have
been issued to  employees  at an  aggregate  purchase  price of  $384,385  and a
weighted  average  purchase price of $3.77 per share pursuant to offerings under
the Purchase Plan and 48,029 shares remained available for future issuance under
the Purchase Plan.

<TABLE>
         The following  table sets forth as to the executive  officers  named in
the table under  "Executive  Compensation"  who purchased shares pursuant to the
Purchase Plan, all current executive officers as a group and all other employees
as a group (i) the  number of shares of the  Company's  Common  Stock  purchased
under the Purchase Plan during the period from its inception  until December 31,
1995;  (ii) the  aggregate  purchase  price  thereof and (iii) the fair value of
stock purchased through December 31, 1995 under the Purchase Plan:


<CAPTION>
                                                                         Number             Aggregate       Fair Value of
                  Name of Individual or                                 of Shares           Purchase           Stock
                    Identity of Group                                   Purchased             Price          Purchased
- ----------------------------------------------------------- ------------------------------------------------------------
<S>                                                                       <C>           <C>                 <C>        
John W. Fara, Ph.D........................................                8,735         $    34,905         $    37,124
John W. Varian............................................               12,943              45,937              55,008
Jeffrey L. Winkelhake, Ph.D...............................                1,321               3,484               5,614
All current executive officers as a group (3 persons).....               22,999              84,326              97,746
All employees as a group (including current officers
   who are not executive officers)........................               78,972             300,059             335,631
</TABLE>

1988 Stock Option Plan

         A total of  1,800,000  shares of the  Company's  Common  Stock has been
reserved for issuance  under the  Company's  1988 Stock Option Plan (the "Option
Plan") adopted by the Board of Directors in 1988 and amended in 1990, 1991, 1992
and 1995.  The Option Plan  expires by its own terms in 1998.  At  December  31,
1995,  options to purchase 889,106 shares were outstanding at a weighted average
exercise price of $4.94 per share and 355,026 options had been exercised.

         The Option Plan  provides for the grant of  "incentive  stock  options"
within the meaning of Section 422 of the Code and nonqualified  stock options to
employees, directors and consultants of the Company. Incentive stock options may
be granted only to employees.  The Option Plan is  administered  by the Board of
Directors, which determines the terms of options granted, including the exercise
price,   the  number  of  shares  subject  to  the  option,   and  the  option's
exercisability.   Options   granted  to  employees  are  generally   immediately
exercisable,  but typically  vest at the rate of 6/48ths of the shares after six
months and an additional 1/48th of the shares per month thereafter.

         The Option Plan  requires  that the exercise  price of incentive  stock
options  must be at least equal to the fair  market  value of such shares on the
date of grant and the exercise  price of  nonqualified  stock options must be at
least 85% of the fair market value of such shares on the date of the grant.  The
maximum term of options granted under the Option Plan is ten years. With respect
to any participant who owns stock  possessing more than 10% of the voting rights
of the Company's  outstanding  capital  stock,  the exercise price of any option
must be at least equal to 110% of fair market value on the date of grant and the
term may be no longer than five years.

                                      -11-
<PAGE>

         Pursuant  to the Option  Plan,  in the event of certain  mergers of the
Company  with other  entities,  transfers  of voting  control  of the  Company's
capital stock or sales of all or substantially all of the Company's assets,  the
Company will request that the acquiring  entity assume the Company's  rights and
obligations  under the Option Plan or provide  similar  options in  substitution
therefor.  If the  acquiring  entity  chooses  not to  assume  such  rights  and
obligations or provide substitute options, then the Company's Board of Directors
will cause all outstanding options (together with shares purchased upon exercise
thereof) to become fully vested prior to the event causing such acceleration and
all unexercised options will terminate upon completion of such event.

         Please see  "Executive  Compensation  and Other  Matters  --  Executive
Compensation  -- Option Grants in Fiscal 1995" for  information  with respect to
the grant of options to the executive  officers  during fiscal 1995.  During the
fiscal year ended December 31, 1995, all current  executive  officers as a group
and all employees as a group were granted options to purchase 485,740 shares and
547,080 shares, respectively,  at a weighted average exercise price of $4.84 per
share, pursuant to the Option Plan.

1992 Consultant Stock Plan

         A total  of  50,000  shares  of the  Company's  Common  Stock  has been
reserved  for  issuance  under the  Company's  1992  Consultant  Stock Plan (the
"Consultant  Plan") adopted by the Board of Directors in 1992.  This plan allows
the  Company to  compensate  consultants  in Company  stock  rather than cash in
certain  situations where the Company deems it desirable.  At December 31, 1995,
12,659 shares had been issued under the Consultant Plan.


                                      -12-
<PAGE>
                                 PROPOSAL NO. 2

                             APPROVAL OF ADOPTION OF
                          THE 1995 DIRECTOR OPTION PLAN

         At the Annual  Meeting,  the  shareholders  are being  asked to approve
adoption of the Company's 1995 Director Option Plan (the "Director Plan") and to
approve  200,000  shares  reserved for issuance  under the  Director  Plan.  The
Director  Plan was adopted by the Board of Directors in June 1995.  The Board of
Directors  intends  to add new  outside  directors  as  outside  candidates  are
identified.  The Company  believes  that the  ability to grant stock  options to
directors is an important  factor in attracting and retaining the best available
personnel for service as directors of the Company.  The initial grant of options
under the  Director  Plan will be made when the first new  outside  director  is
added to the Board.

         The Director Plan is designed to provide for the granting,  by means of
a predetermined schedule, of nonstatutory stock options to the Company's outside
directors.  The purpose of the Director Plan is to provide equity  incentives to
outside  Board members  while  preserving  the ability of these members to grant
options  or other  equity  awards to other  directors  and/or  employees  of the
Company in compliance with Rule 16b-3 of the Securities Exchange Act of 1934, as
amended  (the  "Exchange  Act").  Rule  16b-3  provides  an  exemption  from the
liability  provisions  of Section 16 under the Exchange Act for certain  routine
transactions under employee benefit plans.

Vote Required for Approval of Adoption

         The affirmative vote of the majority of the Votes Cast will be required
under  California  law to approve the  adoption of the Director  Plan.  For this
purpose,  the "Votes Cast" are defined under  California law to be the shares of
the  Company's  Common Stock  present in person or  represented  by proxy at the
Annual Meeting of Shareholders  and "entitled to vote on the subject matter." In
addition, the affirmative votes must contain at least a majority of the required
quorum, which quorum is a majority of the shares outstanding on the Record Date.
Votes that are cast  against  the  proposal  will be  counted  for  purposes  of
determining  (i) the  presence  or absence of a quorum  for the  transaction  of
business and (ii) the total  number of Votes Cast with respect to the  proposal.
While there is no  definitive  statutory or case law  authority as to the proper
treatment  of  abstentions  in the  counting of votes with respect to a proposal
such as the adoption of the Director Plan, the Company believes that abstentions
should be counted for purposes of  determining  both (i) the presence or absence
of a quorum for the  transaction  of business and (ii) the total number of Votes
Cast with respect to the proposal.  In the absence of  controlling  precedent to
the  contrary,  the  Company  intends  to  treat  abstentions  in  this  manner.
Accordingly,  an  abstention  will have the same  effect as a vote  against  the
proposal.  Broker  non-votes  will be counted for  purposes of  determining  the
presence or absence of a quorum for the transaction of business, but will not be
counted for purposes of determining the number of Votes Cast with respect to the
particular proposal on which the broker has expressly not voted.

         The Company's  Board of Directors  recommends a vote "FOR"  approval of
the Director Plan and of the 200,000 shares reserved for issuance thereunder.

Summary of the 1995 Director Plan

         The essential features of the Director Plan are outlined below.

                                      -13-
<PAGE>

Purpose

         The  purposes of the  Director  Plan are to attract and retain the best
available  individuals  for  service as  non-employee  directors  of the Company
("Outside Directors"),  to provide additional incentive to the Outside Directors
and to encourage their continued service on the Board.

Administration

         The  Director  Plan,  and the right of  Outside  Directors  to  receive
options and purchase stock  thereunder,  is intended to qualify as a plan having
"disinterested  administration"  under Rule 16b-3  pursuant to the Exchange Act.
The Director  Plan is  administered  by the Board of  Directors,  who receive no
additional  compensation  for such  service.  All  grants of  options  under the
Director Plan are automatic and  non-discretionary  pursuant to the terms of the
Director  Plan. All questions of  interpretation  or application of the Director
Plan are determined by the Board, whose decisions are final and binding upon all
participants.

Eligibility

         Options  under  the  Director  Plan  may be  granted  only  to  Outside
Directors  of the  Company.  As of the  Record  Date,  there  were  six  Outside
Directors of the Company,  all of whom have been nominated to serve as directors
for the 1996 fiscal year.  These  individuals were eligible to receive grants of
options on the effective date of the Director Plan which was June, 1995.

Participation

         Participation in the Director Plan provides for grants of options to be
made in two ways:

                  a. Each Outside Director is automatically granted an option to
         purchase 25,000 shares (the "First Option") upon the date on which such
         individual  first becomes a director,  whether through  election by the
         shareholders of the Company or by appointment by the Board of Directors
         in order to fill a vacancy; provided, however, in lieu of being granted
         a First  Option,  an Outside  Director  who,  immediately  prior to the
         effective  date of the  Director  Plan,  was an  Outside  Director,  is
         automatically  granted an option to purchase 5,000 shares (the "Initial
         Option").

                  b. Each  Outside  Director  who has served on the Board for at
         least  six   months   after  the  grant  of  the  First   Option   (or,
         alternatively,  the Initial Option), is automatically granted an option
         to purchase 5,000 shares (the "Subsequent  Option") on the first day of
         each fiscal year.

Terms of Options

         Each option  granted  under the Director Plan is evidenced by a written
stock  option  agreement  between  the  Company  and the  optionee.  Options are
generally subject to the terms and conditions listed below.

         Exercise  of the  Option.  The First  Option  (or,  alternatively,  the
Initial Option)  becomes  exercisable at the rate of one  forty-eighth  (1/48th)
each  month  after the date of grant,  with the effect  that this  option is not
exercisable as to the full number of shares until the fourth  anniversary of the
date of its grant. The Subsequent Option also becomes exercisable at the rate of
one forty-eighth  (1/48th) every month after the date of grant,  with the effect
that this option is not  exercisable  as to the full number of shares  until the
fourth anniversary of the date of its grant.  Options granted under the Director
Plan expire ten years following the date of grant. An

                                      -14-
<PAGE>

option  is  exercised  by  giving  written  notice of  exercise  to the  Company
specifying  the number of full  shares of Common  Stock to be  purchased  and by
tendering  payment of the  purchase  price.  Payment for shares  purchased  upon
exercise of an option shall be in such form of consideration as is authorized by
the Director Plan and  determined by the Board,  and such form of  consideration
may vary for each option.

         Exercise  Price.  The per share  exercise price for shares to be issued
pursuant to exercise of an option  under the  Director  Plan is 100% of the fair
market value per share of the Company's Common Stock on the date of grant of the
option.  The fair market value is  determined by the closing price on the NASDAQ
National Market on the last market trading day prior to the date of the grant of
the option.  As of the Record Date,  the per share market value of the Company's
Common Stock was $3.4375,  based on the closing price on that date on the NASDAQ
National Market.

         Termination of Continuous Status as Director.  If an optionee ceases to
serve as a director,  he may,  but only within  three  months  after the date he
ceases to be a director of the  Company,  exercise his option to the extent that
he was entitled to exercise it at the date of such  termination (but in no event
later than the  expiration of its ten year term).  To the extent that he was not
entitled to exercise the option at the date of such  termination,  or if he does
not exercise such option within the time specified, the option terminates.

         Disability,  Death.  In the event that a director is unable to continue
his  service  as such with the  Company  as a result of his total and  permanent
disability (as defined in Section 22(e)(3) of the Code) or if an optionee should
die while a director  of the  Company,  he or his estate  may,  but only  within
twelve months from the date of termination due to disability or death,  exercise
his option to the extent he was  entitled to exercise  his option at the date of
such  termination  (but in no event  later than the  expiration  of its ten year
term). To the extent that he was not entitled to exercise the option at the date
of such termination, or if he or his estate does not exercise such option within
the time specified, the option terminates.

         Liquidation or Dissolution.  In the event of a proposed  liquidation or
dissolution  of the Company,  options  under the Director  Plan shall  terminate
unless  otherwise  provided by the Board. In such event,  the Board, in its sole
discretion,  may  determine to make options  immediately  exercisable  as to all
shares.

         Change of Control.  The Director  Plan provides  (assuming  approval of
this  proposal  No. 2) that in the event of a "Change of Control" of the Company
(as defined  below) all stock options  outstanding as of the date such Change of
Control is determined to have occurred,  that are not yet exercisable and vested
on such date will become immediately vested and fully exercisable.  A "Change of
Control"  means  the  occurrence  of (i) the  acquisition  by a person or entity
(other than the Company,  one of its  subsidiaries or a Company employee benefit
plan or trustee thereof) of securities  representing 50% or more of the combined
voting power of the Company,  (ii) a  transaction  involving  the sale of all or
substantially all of the assets of the Company or the merger or consolidation of
the  Company  with  or  into  another  corporation,   other  than  a  merger  or
consolidation  where  the  shareholders  immediately  prior to such  transaction
continue to own  securities  representing  at least 50% or more of the  combined
voting power of the Company,  or (iii) a change in the  composition of the Board
as a result of which  fewer  than a  majority  of the  directors  are  incumbent
directors. Incumbent directors are directors who either (a) are directors of the
Company as of the date the Director Plan is approved by the shareholders, or (b)
are elected, or nominated for election, to the Board of Directors of the Company
with the affirmative votes of at least a majority of the incumbent  directors at
the time of such  election or  nomination,  but shall not include an  individual
(who is not otherwise an incumbent  director) whose election or nomination is in
connection with an actual or threatened  proxy contest  relating to the election
of directors of the Company.

                                      -15-
<PAGE>

         Capital  Changes.  In the event of any  changes  made in the  Company's
capitalization  which  result in an  exchange  of Common  Stock for a greater or
lesser number of shares without receipt of consideration, appropriate adjustment
shall be made in the  exercise  price and in the  number of  shares  subject  to
options  outstanding  under the Director  Plan,  as well as the number of shares
reserved for issuance under the Director Plan.

         Nontransferability of Option.  Options granted pursuant to the Director
Plan may not be sold, pledged, assigned,  hypothecated,  transferred or disposed
of in any manner  other  than by will or by the laws of descent or  distribution
and may be exercised, during the lifetime of the optionee, only by the optionee.

         Other  Provisions.  The option  agreement may contain such other terms,
provisions  and  conditions  not  inconsistent  with the Director Plan as may be
determined by the Board.

Amendment and Termination of the Director Plan

         The Board may at any time  amend,  alter,  suspend or  discontinue  the
Director Plan, but no amendment, alteration,  suspension or discontinuance shall
be  made  which  would  impair  the  rights  of any  optionee  under  any  grant
theretofore  made without such optionee's  consent.  In addition,  to the extent
necessary and desirable to comply with Rule 16b-3 (or any other  applicable  law
or regulation,  including the  requirements of the NASD or an established  stock
exchange), the Company shall obtain shareholder approval of any amendment to the
Director Plan in such a manner and to such a degree as required.

Tax information - The Director Plan

         Options  granted  pursuant  to  the  Director  Plan  are  "nonstatutory
options" and will not qualify for any special tax benefits to the optionee.

         An  optionee  will not  recognize  any  taxable  income at the time the
option is granted.  Upon  exercise of the option,  the optionee  will  generally
recognize  ordinary income for federal tax purposes  measured by the excess,  if
any, of the fair market  value of the shares over the  exercise  price.  Because
shares  held by  directors  might be subject  to  restrictions  on resale  under
Section 16(b) of the Exchange  Act, the date of taxation may be deferred  unless
the optionee  files an election with the Internal  Revenue  Service  pursuant to
Section 83(b) of the Code within thirty days after the date of exercise.

         Upon a resale  of shares  acquired  pursuant  to,  an option  under the
Director Plan, any difference between the sales price and the exercise price, to
the extent not recognized as ordinary income as provided above,  will be treated
as capital gain or loss. The tax rate on net capital gain (net long-term capital
gain minus net  short-term  capital loss) is capped at 28%.  Capital  losses are
allowed in full against capital gains plus $3,000 of other income.

         The Company  will be entitled to a tax  deduction  in the amount and at
the time that the  optionee  recognizes  ordinary  income with respect to shares
acquired upon exercise of an option under the Director  Plan. The Company is not
required to withhold any amount for tax purposes on any such income  included by
the optionee.

         The foregoing summary of the effect of federal income taxation upon the
optionee and the Company with respect to the grant of options under the Director
Plan  does not  purport  to be  complete,  and  reference  should be made to the
applicable provisions of the Code. In addition, this summary does

                                      -16-
<PAGE>

not discuss the provisions of the income tax laws of any municipality,  state or
foreign country in which the optionee may reside.


                                 PROPOSAL NO. 3

                          APPROVAL OF AMENDMENT TO THE
                        1991 EMPLOYEE STOCK PURCHASE PLAN

         The 1991 Employee Stock Purchase Plan (the "Purchase Plan") was amended
by the Board of Directors in March 1996 to reserve an additional  100,000 shares
of Common Stock for issuance thereunder.  The Purchase Plan had reserved 150,000
shares of which  133,079  shares had been issued as of April 30,  1996,  leaving
16,921 shares available for issuance.  The amendment will increase the number of
shares  available  for issuance  under the Purchase  Plan from 16,921 to 116,921
shares.

         Approval of the  addition of 100,000  shares to the pool  reserved  for
issuance under the Purchase Plan requires the affirmative vote of the holders of
a majority of the shares  present in person or represented by proxy and entitled
to vote at the meeting.

         The Company  believes that its Purchase Plan is an important  factor in
attracting and retaining skilled personnel.

         The Company's  Board of Directors  recommends a vote "FOR"  approval of
the amendment to the Purchase Plan to reserve an additional  100,000  shares for
issuance thereunder.

         The essential features of the Purchase Plan are outlined below.

General

         The Purchase  Plan,  and the right of  participants  to make  purchases
thereunder,  is intended to qualify under the provisions of Sections 421 and 423
of the Internal Revenue Code. See "Tax Information - The Purchase Plan."

Purpose

         The purpose of the Purchase Plan is to provide employees of the Company
with an  opportunity  to  purchase  Common  Stock of the  Company  at a discount
through accumulated payroll deductions.

Administration

         The  Purchase  Plan is  administered  by the  Board of  Directors,  who
receive  no  additional   compensation  for  such  service.   All  questions  of
interpretation  or  application of the Purchase Plan are determined by the Board
or its  appointed  committee,  whose  decisions  are final and binding  upon all
participants.  Members of the Board who are eligible  employees are permitted to
participate  in the Purchase  Plan but may not vote on any matter  affecting the
administration  of the Purchase Plan or the grant of any option  pursuant to the
Purchase Plan.

                                      -17-
<PAGE>

Eligibility

         Any person who has been  employed  by the  Company  for at least  three
consecutive  months is eligible to participate in the Purchase Plan,  unless the
employee would own 5% or more of the total combined voting power or value of all
classes of stock of the Company or of its subsidiaries (including stock issuable
upon  exercise  of options  held by such  employee)  at the end of the  offering
period, or the employee would receive more than $25,000 worth of stock (computed
as of the date of grant)  pursuant to the Purchase Plan in any calendar year. As
of the Record Date,  approximately  57 employees were eligible to participate in
the Purchase Plan.

Offering Dates

         The Purchase Plan is generally  implemented  by  consecutive  six month
offering periods. Offering periods commence on or about April 1 and October 1 of
each year.

Enrollment in the Plan

         Eligible  employees  become   participants  in  the  Purchase  Plan  by
delivering to the Company's payroll office a subscription  agreement authorizing
payroll  deductions.  Under  the  Purchase  Plan,  once an  employee  elects  to
participate in the Purchase Plan,  enrollment in each successive offering period
occurs  automatically  unless the employee  withdraws from  participation in the
Purchase Plan.

Purchase Price

         The purchase  price per share under the  Purchase  Plan is the lower of
(i) 85% of the  fair  market  value of a share  of  Common  Stock on the date of
commencement of the offering (or, for employees beginning  participation  later,
the date such  participation  began) or (ii) 85% of the fair  market  value of a
share of Common  Stock on the last day of the offering  period.  The fair market
value of the  Common  Stock on a given  date is the  closing  sale  price of the
Company's Common Stock, as reported on the NASDAQ National Market.

Payment of Purchase Price; Payroll Deductions

         The purchase price of the shares is  accumulated  by after-tax  payroll
deductions  over the offering  period.  The  deductions  may not exceed 10% of a
participant's  compensation.  The  total  number  of  shares  purchased  by  any
participant shall in no event exceed, in any calendar year, the number of shares
of Common Stock which $25,000 could purchase at the fair market value of a share
of the Company's Common Stock, calculated as of the offering date. A participant
may discontinue participation in the Purchase Plan, and may decrease or increase
the rate of payroll deductions during the offering period.

Purchase of Stock; Exercise of Option

         By executing a  subscription  agreement to  participate in the Purchase
Plan, the employee is entitled to have shares placed under option to him or her.
The maximum number of shares placed under option to a participant in an offering
is that number  determined  by dividing  the total  amount of the  participant's
contribution  for the offering period by the lower of (i) 85% of the fair market
value of the Common Stock at the  beginning of the offering  period (or the date
such employee's participation began) or (ii) 85% of the fair market value of the
Common Stock at the end of the offering period,  but in no event shall more than
the number of shares of Common Stock which  $25,000  could  purchase at the fair
market value of a share of the

                                      -18-
<PAGE>

Company's  Common  Stock,  calculated  as of the offering  date, be placed under
option to a single  participant in any one calendar year.  Unless the employee's
participation  is  discontinued,  the option for the  purchase of shares will be
exercised  automatically  at the end of the  offering  period at the  applicable
price.  No  fractional  shares will be issued upon  exercise of the option.  Any
amounts  insufficient  to  purchase a full share  remaining  in a  participant's
account  after  exercise of the option will be returned to the  participant.  No
interest will accrue on the payroll  deductions of a participant in the Purchase
Plan.

         The initial  offering  period under the Purchase  Plan began on October
10, 1991, and since that date 133,079 shares of the Company's  Common Stock have
been sold under the Purchase  Plan.  The number of shares sold in each  offering
period will vary with the number of  participants,  the amount of their  payroll
deductions and the fair market value of the Company's Common Stock.

Withdrawal

         A  participant's  interest in a given  offering  may be  terminated  by
signing and  delivering to the Company a notice of withdrawal  from the Purchase
Plan.  Upon  withdrawal  from the  Purchase  Plan,  accrued  but unused  payroll
deductions are returned to the employee.

         Such  withdrawal  may be  elected  at any time  prior to the end of the
applicable offering period. A participant's withdrawal from an offering will not
have any effect upon such participant's eligibility to participate in subsequent
offering periods under the Purchase Plan.

Termination of Employment

         Termination of a  participant's  employment  for any reason,  including
retirement or death, cancels participation in the Purchase Plan immediately.  In
such event the payroll deductions credited to the participant's  account will be
returned without interest to such participant,  or, in the case of death, to the
person  or  persons  entitled  thereto  as  specified  by  the  employee  in the
subscription agreement.

Capital Changes

         In the event of changes in the  capitalization of the Company,  such as
stock splits or stock dividends,  which result in an increase or decrease in the
number of shares  of Common  Stock,  without  receipt  of  consideration  by the
Company,  appropriate  adjustments  will be made by the Company in the number of
shares subject to purchase and in the price per share.

Effect of Liquidation, Dissolution, Sale of Assets or Merger

         In the  event  of a  liquidation  or  dissolution  of the  Company,  an
employee's  participation  in the Purchase Plan will be  terminated  immediately
before consummation of such event unless otherwise provided by the Board. In the
event of a sale of all or  substantially  all of the assets of the  Company or a
merger of the Company with or into another  corporation,  the employee's  rights
shall be satisfied by assumption of the Company's  obligations by such acquiring
or  successor   corporation.   If  such  corporation  refuses  to  assume  those
obligations,  the Board shall  shorten the offering  period then in progress and
notify  each  participant  at  least 10 days  prior to the end of the  shortened
offering  period  that  the  right  to  purchase  shares  will be  automatically
exercised,  unless the employee  withdraws from the Purchase Plan prior thereto,
at the end of such shortened offering period.


                                      -19-
<PAGE>

Non-assignability

         No rights or  accumulated  payroll  deductions of an employee under the
Purchase Plan may be pledged,  assigned or transferred  for any reason,  and any
such  attempt may be treated by the Company as an election to withdraw  from the
Purchase Plan.

Reports

         Individual  accounting  will be maintained for each  participant in the
Purchase Plan. Each participant  receives at least annually a report showing the
details of the participant's account.

Amendment and Termination of the Plan

         The Board may at any time  amend,  alter,  suspend or  discontinue  the
Purchase  Plan;  however,   except  under  certain  conditions,   no  amendment,
alteration,  suspension or discontinuation  shall be made which would impair the
rights of any  participant  arising out of any offering period which has already
commenced without such participant's written consent. In addition, to the extent
necessary and desirable to comply with Rule 16b-3 under the Exchange Act or with
Section  423 of the  Internal  Revenue  Code  (or any  other  applicable  law or
regulation,  including  the  requirements  of the NASD or an  established  stock
exchange),  the Company shall obtain  shareholder  approval of any Purchase Plan
amendment in such a manner and to such a degree as required.

Tax Information - The Purchase Plan

         The Purchase  Plan,  and the right of  participants  to make  purchases
thereunder,  is intended to qualify under the provisions of Sections 421 and 423
of the Internal Revenue Code. Under these provisions,  no income will be taxable
to a participant  until the shares purchased under the Purchase Plan are sold or
otherwise  disposed  of.  Upon  sale or other  disposition  of the  shares,  the
participant  will  generally  be  subject  to tax and the amount of the tax will
depend upon the holding period. If the shares are sold or otherwise  disposed of
more than two years from the first day of the offering  period,  the participant
will recognize  ordinary  income measured as the lesser of (a) the excess of the
fair market value of the shares at the time of such sale or disposition over the
purchase  price,  or (b) an amount  equal to 15% of the fair market value of the
shares as of the first day of the offering  period.  Any additional gain will be
treated as long-term capital gain. If the shares are sold or otherwise  disposed
of before the expiration of this holding period,  the participant will recognize
ordinary income generally measured as the excess of the fair market value of the
shares  on the date the  shares  are  purchased  over the  purchase  price.  Any
additional  gain or  loss on such  sale  or  disposition  will be  long-term  or
short-term capital gain or loss, depending on the holding period. The Company is
not entitled to a deduction for amounts taxed as ordinary income or capital gain
to a  participant  except  to  the  extent  of  ordinary  income  recognized  by
participants upon a sale or disposition of shares prior to the expiration of the
holding period(s) described above.

         The  foregoing  is only a  summary  of the  effect  of  federal  income
taxation  upon the  participant  and the  Company  with  respect  to the  shares
purchased  under the Purchase Plan.  Reference  should be made to the applicable
provisions of the Internal Revenue Code. In addition, the foregoing summary does
not discuss the tax consequences of a participant's death or the income tax laws
of  any  state  or  foreign   country  in  which  the  participant  may  reside.
Furthermore, future legislative, administrative or judicial changes could affect
the accuracy of the foregoing summary.

                                      -20-
<PAGE>

Vote Required For Approval of Amendment

         The affirmative vote of the majority of the Votes Cast will be required
under  California  law to approve the amendment to the Purchase  Plan.  For this
purpose,  the "Votes Cast" are defined under  California law to be the shares of
the  Company's  Common Stock  present in person or  represented  by proxy at the
Annual Meeting of Shareholders  and "entitled to vote on the subject matter." In
addition, the affirmative votes must contain at least a majority of the required
quorum, which quorum is a majority of the shares outstanding on the Record Date.
Votes that are cast  against  the  proposal  will be  counted  for  purposes  of
determining  (i) the  presence  or absence of a quorum  for the  transaction  of
business and (ii) the total  number of Votes Cast with respect to the  proposal.
While there is no  definitive  statutory or case law  authority as to the proper
treatment  of  abstentions  in the  counting of votes with respect to a proposal
such  as  the  amendments  of the  Purchase  Plan,  the  Company  believes  that
abstentions  should be counted for purposes of determining both (i) the presence
or absence of a quorum for the transaction of business and (ii) the total number
of Votes  Cast with  respect to the  proposal.  In the  absence  of  controlling
precedent to the  contrary,  the Company  intends to treat  abstentions  in this
manner.  Accordingly,  an abstention will have the same effect as a vote against
the proposal.  Broker  non-votes will be counted for purposes of determining the
presence or absence of a quorum for the transaction of business, but will not be
counted for purposes of determining the number of Votes Cast with respect to the
particular proposal on which the broker has expressly not voted.


                                      -21-
<PAGE>

                                 PROPOSAL NO. 4

                         CONFIRMATION OF APPOINTMENT OF
                              INDEPENDENT AUDITORS

         The  Board of  Directors  has  selected  Ernst & Young LLP to audit the
financial  statements of the Company for the year ending  December 31, 1996, and
recommends  that the  shareholders  confirm  the  selection.  In the  event of a
negative vote, the Board will reconsider its selection.

         Ernst & Young LLP has audited the Company's financial  statements since
its inception.  Representatives  of Ernst & Young LLP are expected to be present
at the meeting, will have the opportunity to make a statement if they so desire,
and are expected to be available to respond to appropriate questions.

                    EXECUTIVE COMPENSATION AND OTHER MATTERS

Executive Compensation
<TABLE>

         Summary   Compensation  Table.  The  following  table  sets  forth  the
compensation paid by the Company for each of the three years in the period ended
December 31, 1995 to the Chief Executive  Officer and each executive  officer of
the Company:
<CAPTION>

                                                                             Long-Term  
                                                Annual Compensation         Compensation
                                           ------------------------------ ----------------
                                                                              Award of         
                                                                               Options           All Other     
 Name and Principal Position      Year        Salary          Bonus(1)       (# of Shares)     Compensation(3) 
- ------------------------------- ---------- -------------- --------------- --------------------------------------
<S>                               <C>           <C>          <C>               <C>               <C>   
John W. Fara, Ph.D.               1995          $240,000     $ 50,000          225,000(2)        $5,674
     President, Chief Executive   1994           225,000           --               --            6,774
     Officer                      1993           205,000       40,000           50,000            6,668

John W. Varian                    1995           135,000       45,000          130,740(2)         3,520
     Vice President, Finance      1994           125,000           --               --            3,882
     and Chief Financial          1993           109,792       20,000           12,500            3,592
     Officer

Jeffrey L. Winkelhake, Ph.D.      1995           145,000       45,000          130,000(2)         3,719
     Vice President,              1994           135,000           --               --            2,948
     Pharmaceutical               1993            89,154       20,000           75,000            6,705
     Development
<FN>
- ----------------
(1)      Represents payments for achievements of corporate objectives in 1995.

(2)      Option awards in 1995 include 75,000,  55,000 and 55,000 shares subject
         to incentive options related to 1995 officer  compensation and 150,000,
         75,740 and 75,000 shares subject to incentive options issued to replace
         options  forfeited  by  Dr.  Fara,  Mr.  Varian  and  Dr.   Winkelhake,
         respectively,  in conjunction  with the elective  extension of exercise
         periods for options granted prior to February 1995.

(3)      Amounts included in "All Other  Compensation"  for 1995 include Company
         matching  contributions to the Anergen Retirement Savings Plan ("401(k)
         Contributions"),  payments  by  the  Company  on  term  life  insurance
         policies  ("Life  Insurance   Payments"),   and  relocation   expenses.
         Specifically, the amount stated for Dr. Fara in 1995 consists of 401(k)
         Contributions  of $3,720 and Life  Insurance  Payments  of $1,954;  the
         amount stated for Mr.  Varian in 1995 consists of 401(k)  Contributions
         of $2,362 and

                                      -22-
<PAGE>

         Life  Insurance  Payments  of  $1,158;  and the  amount  stated for Dr.
         Winkelhake in 1995 consists of 401(k)  Contributions of $2,900 and Life
         Insurance Payments of $819.
</FN>
</TABLE>
<TABLE>

         Option  Grants  in  Fiscal  Year  1995.  In  February  1995,  executive
officers, employees and consultants had the option to elect to extend the option
exercise  period for stock options granted prior to February 1995 by four years.
Elections to extend 555,113  options were made.  The following  table sets forth
each grant of stock options made during the year ended December 31, 1995 to each
executive  officer,  including  150,000,  75,740 and 75,0000  shares  subject to
incentive  options issued to replace  options  forfeited by Dr. Fara, Mr. Varian
and Dr. Winkelhake,  respectively, in conjunction with the elective extension of
exercise periods for options granted prior to February 1995:

<CAPTION>

                              
                                                  Individual Grants                      
                              ----------------------------------------------------------  Potential Realizable Value   
                                Number of    % of Total                                   at Assumed Annual Rates of   
                               Securities      Options                                      Stock Price Appreciation   
                               Underlying    Granted to                                      for Option Term(3)        
                                 Options      Employees     Exercise or    Expiration    ------------------------------
            Name               Granted(1)      in 1995     Base Price(2)      Date               5%              10%
- ------------------------------------------------------------------------------------------------------------------------

<S>                              <C>           <C>           <C>            <C>                <C>             <C>            
John W. Fara, Ph.D...........    100,000       11.8%         $9.00          10/14/01           $      0        $      0
                                  50,000        5.9           5.50          12/28/02             24,009         139,102
                                  75,000        8.8           2.75          03/17/04            288,236         545,346

John W. Varian...............     38,240        4.5           2.00          08/16/00            130,941         185,260
                                  25,000        3.0           9.00          10/14/01                  0               0
                                  12,500        1.5           5.50          12/28/02              6,002          34,776
                                  25,000        3.0           2.75          03/17/04             96,079         181,782
                                  30,000        3.5           3.25          12/13/04            100,294         203,138

Jeffrey L. Winkelhake, Ph.D..     50,000        5.9           7.75          04/07/02                  0          26,602
                                  25,000        3.0           5.50          12/28/02             12,004          69,551
                                  30,000        3.5           2.75          03/17/04            115,294         218,138
                                  25,000        3.0           3.25          12/13/04             83,579         169,282
                                                                      
<FN>
- ----------------
(1)  The listed options become exercisable as to 1/48th of the shares subject to
     the  option at the end of each  month  after  the date of grant,  with full
     vesting  occurring  four years after the date of grant.  Under the terms of
     the Company's  1988 Incentive  Stock Plan,  the Board of Directors  retains
     discretion,  subject to plan  limits,  to modify  the terms of  outstanding
     options and to reprice the options.

(2)  The exercise price and tax withholding  obligations related to exercise may
     in some  cases,  be paid by  delivery  of other  shares or by offset of the
     shares subject to the options.

(3)  The dollar  amounts under these columns are the result of  calculations  at
     the 5% and 10%  rates  set by the SEC and  therefore  are not  intended  to
     forecast the possible future  appreciation,  if any, of the Company's stock
     price.  The  Company  did not use an  alternative  formula for a grant date
     valuation,  as the Company does not believe that any formula will determine
     with  reasonable  accuracy  a  present  value  based on future  unknown  or
     volatile factors.
</FN>
</TABLE>

                                      -23-
<PAGE>
<TABLE>

         Aggregated  Option  Exercises  in Last Fiscal Year and Fiscal  Year-End
Values. The following table sets forth, for each of the executive officers, each
exercise  of stock  options  during the year  ended  December  31,  1995 and the
year-end value of unexercised options:
<CAPTION>

                                                                                             
                                                                    Number of Securities        Value(2) of Unexercised      
                                     Shares                        Underlying Unexercised       In-the-Money Options at      
                                   Acquired on       Value           Options at Year-End               Year-End              
             Name                   Exercise       Realized(1)    Exercisable/Unexercisable     Exercisable/Unexercisable    
- -------------------------------------------------- -----------  ---------------------------- ------------------------------  
<S>                                 <C>              <C>              <C>                          <C>    
John W. Fara, Ph.D.............     157,000          $280,889         150,220/106,780              $148,588/$91,413
John W. Varian.................           0                 0           68,967/61,773               $93,074/$60,467
Jeffrey L. Winkelhake, Ph.D....           0                 0           51,471/78,529                $8,438/$61,563
                                                                                             
<FN>                                          
- ----------------
(1)  Based on the closing  price of the  Company's  Common  Stock on the date of
     exercise.

(2)  Based on a fair market  value of $4.25  which was the closing  price of the
     Company's stock on December 29, 1995.
</FN>
</TABLE>

Compensation of Directors

         Directors  currently  receive  no fees for  services  provided  in that
capacity  but are  reimbursed  for  out-of-pocket  expenses in  connection  with
attendance at Board of Directors' meetings.  During 1995, Dr. McConnell was paid
$12,000 by the Company in connection  with consulting  services  provided to the
Company. Outside directors are granted nonstatutory stock options under the 1995
Director Option Plan.  Currently there are six Outside  Directors,  but only two
have elected to receive  grants of options under the 1995 Director  Option Plan.
Please see "Employee Benefit Plans -- 1995 Director Option Plan" for information
with respect to the 1995 Director Option Plan.

Employment Contracts, Termination and Change of Control Arrangements

         The 1995 Director Option Plan provides that upon a change in control of
the Company, the unvested portion of all options held by Outside Directors shall
become immediately exercisable.  The 1988 Stock Option Plan provides that in the
event of a change in control of the Company, outstanding stock options and stock
purchase  rights  shall be assumed  or  equivalent  options  or rights  shall be
substituted by the successor entity.  Unless such successor corporation does not
agree to such assumption or substitution,  the Company's Board of Directors must
provide for the options or rights to become immediately exercisable in full.

         In  February,   1996  the  Company   entered  into  an  agreement  (the
"Agreement")  with  John W.  Fara,  Ph.D.,  the  Company's  President  and Chief
Executive  Officer,  regarding his  retirement  from the Company.  The Agreement
provides that Dr. Fara will  transition from full time service as a director and
as  President  and Chief  Executive  Officer to  part-time  employment  upon the
earlier of (i) June 30, 1996, (ii) the  determination  by the Board of Directors
that Dr. Fara's full-time services are no longer required, or (iii) consummation
of a  corporate  reorganization,  or  sale  of all or  substantially  all of the
outstanding  stock or assets of the  Company.  At the request of the Board,  Dr.
Fara has agreed to consider  extending  his  services  full-time to a time after
June 30, 1996, as mutually agreed. At the time of the transition,  Dr. Fara will
resign as President and Chief Executive  Officer and from the Board of Directors
and for the twelve  months  thereafter,  Dr.  Fara shall  serve the Company on a
part-time employment basis.

         Under the  Agreement,  Dr. Fara  receives a salary at an annual rate of
$250,000. Dr. Fara is also eligible for bonuses for each substantial development
or license  agreement that the Company enters into with certain third parties or
in the event of a sale of all or substantially all the Company's assets,  merger
or consolidation of the Company with any other corporation  within six months of
the transition date. Dr. Fara's

                                      -24-
<PAGE>

stock  options  continue to vest as long as he is employed on a part-time  basis
and when he is no  longer an  employee  all  options  to  acquire  shares of the
Company's  Common  Stock  which  were  unvested  as of such  date  become  fully
exercisable.

         There are no other employment  contracts between the Company and any of
the Company's executive  officers,  and there are no other compensatory plans or
arrangements  with respect to an executive officer which will result in payments
upon  resignation,  retirement,  or any  other  termination  of  such  executive
officer's employment or from a change of control of the Company.

Report of the Compensation Committee of the Board of Directors

         The Compensation  Committee has been a standing  committee of the Board
of  Directors  of Anergen,  Inc.  since prior to the  Company's  initial  public
offering  on  October  10,  1991.   Throughout  its  history,   only  "outside",
nonemployee Directors have served on this committee. Among its other duties, the
Compensation  Committee  is charged with the  responsibilities,  subject to full
Board of Directors' approval, of establishing, periodically reevaluating and (as
appropriate)  adjusting,  and  administering  Company  policies  concerning  the
compensation of management personnel,  including the CEO and all other officers.
In  discharging  such duties,  the  Compensation  Committee is  responsible  for
annually  determining and  recommending to the full Board the annual base salary
for each officer and for  establishing  the criteria  under which cash incentive
bonuses may be paid to such officers for the year. In addition, the Committee is
responsible for administering the Company's Stock Option Plan.

         The Company uses a simple total  compensation  program that consists of
cash- and equity-based  compensation.  Having a compensation program that allows
the  Company to  successfully  attract  and retain key  employees  permits it to
develop its technology  toward  commercialization,  enhance  shareholder  value,
motivate  technological  innovation,  foster  teamwork,  and  adequately  reward
employees.

         Cash Salaries and Bonuses. Base salaries for new officers are initially
established  by evaluating the  responsibilities  of the position to be held and
the  experience  of  the  individual,   and  by  reference  to  the  competitive
marketplace  for executive  talent,  including a comparison to base salaries for
comparable  positions at other companies.  Companies used in the comparison were
selected based upon comparable  employee  headcount,  market  capitalization and
stage of product  progression.  In determining  its  recommendations  for annual
adjustment  to  officers'  compensation  packages,  the  Compensation  Committee
focuses  primarily  on similar  executive  marketplace  data,  including  survey
material on salary  movements for peer  executives,  in determining  base salary
adjustments.  In the context of  individual  performance,  Company  performance,
survey data, and positions  responsibility  level,  the Chief Executive  Officer
recommended  to the  Committee a base salary for fiscal 1995 for each  officer's
position,  but excluding the Chief Executive Officer. The Compensation Committee
determined the Chief Executive  Officer's salary  adjustment  considering  these
same  criteria.  The officers'  salaries for 1995  corresponded  with the median
range of comparable  companies.  When  evaluating and deciding upon cash bonuses
the Compensation Committee gives consideration to the individual's contributions
towards the Company's  success in moving  toward its long-term  goals during the
fiscal year,  the  performance  of the Common  Stock  during that year,  and its
assessment  of the quality of  services  rendered  by the  officer.  Because the
Company  is  in  the  research  and  development  stage  the  typical  financial
performance   methodology  of  evaluating  the  Company's   performance  is  not
appropriate.  Cash  bonuses  can  be  awarded  at  the  Board's  discretion  for
exceptional contributions to the Company's success. The officers' performance is
directly  related  to  corporate  performance  objectives,  defined  based  upon
industry  standards of progression  towards the  development  of  pharmaceutical
products,   and  bonuses  are  awarded  based  upon  the  achievement  of  those
objectives.

                                      -25-
<PAGE>

         Stock  Option  Program.  The  purpose  of this  program  is to  provide
additional  incentives to employees who are expected to contribute materially to
the  Company's  success in the future.  The  Committee  believes  stock  options
encourage the  achievement  of superior  results over time and align officer and
shareholder  interests.  The option  program also  utilizes  vesting  periods to
encourage  key  employees to continue in the employ of the Company.  The Company
grants stock options annually to a broad-based  population of the total employee
pool.  The size of the stock  option  grants to each  officer are based upon the
Board's evaluation of the officer's contribution to the achievement of corporate
performance objectives.  The Chief Executive Officer recommends to the Committee
proposed  stock option grants for the Company's  officers,  other than the Chief
Executive  Officer.  Stock option  grants to each  officer  other than the Chief
Executive  Officer are reviewed and approved by the  Committee in the context of
the  following  factors:  the  Company's  performance  to date  relative  to its
objectives,  the  responsibility  level and  performance  of the officer,  prior
option grants to the officer and the level of vested and unvested  options.  The
Compensation  Committee  determines the Chief  Executive  Officer's stock option
grant considering the same criteria.  The Board provided all executive officers,
employees and  consultants  holding options under the 1988 Stock Option Plan the
opportunity  during the month of February  1995 to elect to extend  their option
exercise period by four years.  Elections were made to extend options to acquire
555,113 shares of Common Stock.

         Compensation  of  Chief  Executive  Officer.  The  compensation  of the
Company's  Chief  Executive  Officer  for 1995 was based  upon the same  general
criteria  as  described  above  for  executive   officers.   Specifically,   the
Compensation  Committee  considered  several factors as important in determining
the  Chief  Executive's   compensation  in  1995.  These  factors  included  the
attainment  of  certain  research  and  development  objectives,  the  Company's
progress  in  proceeding  towards  clinical  trials and its  progress in ongoing
clinical  testing,  the  Committee's  assessment  of the  Company's  efforts  to
consummate new corporate  partnering  arrangements  for product  development and
marketing,  and the  performance of the Company's  stock during the year.  After
considering  these and other factors,  the Committee  concluded that the Company
made  progress  in  proceeding  toward  these  goals in 1995 on which  the Chief
Executive Officer's compensation was based.

Summary

         The members of the  Compensation  Committee  of the Board of  Directors
believe that the Company's  compensation  programs are  successful in attracting
and retaining qualified employees and tying compensation directly to performance
for  shareholders.  We will continue to monitor  closely the  effectiveness  and
appropriateness  of each of the components of compensation to reflect changes in
the Company's business environment.

                                          Respectfully submitted,

                                          Harry H. Penner, Jr.
                                          James E. Thomas
                                          Nicole Vitullo


                                      -26-
<PAGE>

Performance Graph

         The following graph shows a comparison of cumulative total  shareholder
returns for the Company's  Common  Stock,  the  NASDAQ composite  index for U.S.
companies  ("Nasdaq"),  and an index of NASDAQ-listed  pharmaceutical  companies
("Pharma")  published  by the  Center for  Research  in  Security  Prices at the
University  of Chicago and provided by Nasdaq to its members.  The graph assumes
the  investment of $100 on October 10, 1991,  the date of the Company's  initial
public offering.  The performance shown is not necessarily  indicative of future
performance.


[The following  descriptive  data is supplied in accordance  with Rule 304(d) of
Regulation S-T]


                               Cumulative Total Return
        -----------------------------------------------------------------------
        10/10/91    12/31/91    12/31/92    12/31/93    12/31/94       12/31/95
Anergen   100          133        128          63         23              53 
NASDAQ    100          116        135         155        151             214
Pharma    100          127        107          96         72             131
                                  



Compliance with Section 16(a) of the Exchange Act

         Section  16(a) of the Exchange Act  requires  the  Company's  executive
officers and directors and persons who own more than ten percent of a registered
class of the  Company's  equity  securities  to file  reports of  ownership  and
changes in ownership with the Securities and Exchange Commission ("SEC") and the
National Association of Securities Dealers,  Inc. Executive officers,  directors
and greater  than ten percent  shareholders  are required by SEC  regulation  to
furnish the Company  with  copies of all  Section  16(a) forms they file.  Based
solely on its review of the copies of such forms  received  by it, or on written
representations  from certain  reporting  persons,  the Company  believes  that,
during the fiscal year ended  December 31, 1995,  all filing  requirements  were
complied with applicable to its executive officers and directors.


                                      -27-
<PAGE>

                                  OTHER MATTERS

         The Company  knows of no other  matters to be submitted to the meeting.
If any other matters  properly  come before the meeting,  it is the intention of
the persons named in the enclosed  proxy card to vote the shares they  represent
as the Board of Directors may recommend.

                                            THE BOARD OF DIRECTORS

Dated: May 24, 1996




THE COMPANY WILL MAIL WITHOUT CHARGE TO ANY  SHAREHOLDER  UPON WRITTEN REQUEST A
COPY OF THE COMPANY'S ANNUAL REPORT ON FORM 10-K FOR THE YEAR ENDED DECEMBER 31,
1995,  INCLUDING  THE  FINANCIAL  STATEMENTS,  SCHEDULES AND A LIST OF EXHIBITS.
REQUESTS  SHOULD BE SENT TO INVESTOR  RELATIONS,  ANERGEN,  INC.,  301 PENOBSCOT
DRIVE, REDWOOD CITY, CA 94063.

                                      -28-
<PAGE>
                                                                      APPENDIX A

PROXY                             ANERGEN, INC.                            PROXY
                                                               
               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                       1996 ANNUAL MEETING OF SHAREHOLDERS

     The undersigned  shareholder(s) of Anergen, Inc., a California corporation,
hereby acknowledges  receipt of the Notice of Annual Meeting of Shareholders and
Proxy  Statement for the 1996 Annual Meeting of  Shareholders to be held on June
26, 1996, and hereby appoints John W. Fara, Ph.D. and John W. Varian and each of
them, as Proxies,  with power of  substitution,  to represent the undersigned at
such meeting and at any  adjournments thereof, and to vote all shares of Common
Stock which the undersigned is entitled to vote, as designated below.

     In their  discretion  the  Proxies are  authorized  to vote upon such other
business as may properly come before the meeting.

     UNLESS A CONTRARY DIRECTION IS INDICATED,  THIS PROXY WILL BE VOTED FOR THE
ELECTION OF  DIRECTORS  AS SET FORTH IN PROPOSAL 1, FOR APPROVAL OF THE ADOPTION
OF THE 1995 DIRECTOR  OPTION PLAN AS SET FORTH IN PROPOSAL 2, FOR APPROVAL OF AN
AMENDMENT TO THE 1991  EMPLOYEE  STOCK  PURCHASE PLAN AS SET FORTH IN PROPOSAL 3
AND FOR  CONFIRMATION  OF ERNST & YOUNG LLP AS AUDITORS AS SET FORTH IN PROPOSAL
4.

- --------------------------------------                                        
COMMENTS/ADDRESS/CHANGE:  PLEASE MARK             (Continued, and to be signed 
  COMMENT/ADDRESS BOX ON REVERSE SIDE                   on the other side)     
                                                
                              FOLD AND DETACH HERE

<PAGE>
                                                            [ X ]    Please mark
                                                                      your votes
                                                                        as this 
                                                                             
THE BOARD OF DIRECTORS  RECOMMENDS
A VOTE FOR THE NOMINEES  LISTED BELOW                                  
AND FOR PROPOSALS 2, 3 AND 4.
                                                                       
Proposal 1-- To elect directors to serve for
       the ensuing year and until their                                  
       successors are elected.                                            
Nominees:                                                   FOR       FOR ALL 
Bruce L.A. Carter, Ph.D., John W. Fara, Ph.D., Nicholas J.                 
Lowcock, Harden M. McConnell, Ph.D., Harry H. Penner,       [   ]       [   ]
Jr., James E. Thomas, and Nicole Vitullo

If you wish to withhold authority to vote 
for any individual  nominee,  strike a
line through that nominee's name.
                                                                          
I PLAN TO ATTEND THE MEETING                                   [   ]      
<TABLE>
<CAPTION>
<S>                                                                                           <C>       <C>           <C>
                                                                                              FOR       AGAINST      ABSTAIN 
                              
Proposal 2 -- To approve adoption of the 1995 Director Option Plan.                           [   ]       [   ]        [   ]

Proposal 3 -- To approve an amendment to the 1991 Employee  Stock  Purchase Plan increasing   [   ]       [   ]        [   ]
        the number of shares available for issuance under the plan.

Proposal 4 -- To  confirm  the  appointment  of  Ernst & Young LLP as  independent auditors   [   ]       [   ]        [   ]
        of  the  company  for  the 1996 fiscal year.
</TABLE>

Please sign exactly as name appears  hereon.  If the stock is  registered in the
names  of  two  or  more   persons,   each  person   should   sign.   Executors,
administrators,  trustees,  guardians  and  attorneys-in-fact  should  add their
titles. If signer is a corporation, please give the full corporate name and have
a duly  authorized  officer sign,  stating  title.  If signer is a  partnership,
please sign in the partnership name by the authorized person.


               COMMENTS/ADDRESS CHANGE
          Please  mark  this box if you have 
           written comments/address change          [    ]
                 on the reverse side            
                    
                    

Signature(s)                                              Date 
            --------------------------------------------       -----------------

Note:  Please vote,  date and promptly  return this proxy in the enclosed return
envelope which is postage prepaid if mailed in the United States.

                              FOLD AND DETACH HERE



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