ANERGEN INC
SC 13D/A, 1996-08-15
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>

                                       UNITED STATES
                            SECURITIES AND EXCHANGE COMMISSION
                                  Washington, D.C. 20549


                                       SCHEDULE 13D

                         Under the Securities Exchange Act of 1934
                                    (Amendment No. 2)*

                                       Anergen, Inc.
- --------------------------------------------------------------------------------
                                      (Name of Issuer)

                                Common Stock, no par value
- --------------------------------------------------------------------------------
                               (Title of Class of Securities)

                                         034602102
                                      (CUSIP Number)

                                    Reuben S. Leibowitz
                              E.M. Warburg Pincus & Co., Inc.
                                   466 Lexington Avenue
                                 New York, New York 10017
                                      (212) 878-0600
- --------------------------------------------------------------------------------
(Name, Address and Telephone Number of Person Authorized to Receive Notices and
                                 Communications)

                                     - with a copy to -

                                  Steven J. Gartner, Esq.
                                 Willkie Farr & Gallagher
                                   153 East 53rd Street
                                 New York, New York 10022


                                      August 9, 1996
- --------------------------------------------------------------------------------
                  (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box [_]

Check the  following  box if a fee is being paid with the statement [_](A fee is
not required only if the reporting person:  (1) has a previous statement on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7.)

Note:  Six copies of this  statement,  including all exhibits,  should be filed
with the  Commission.  See Rule 13d-l(a) for other parties to whom copies are
to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The  information  required  on  the  remainder  of  this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the  Securities   Exchange
Act of 1934 ("Act") or otherwise  subject to the liabilities of that section  of
the Act but shall  be subject to all  other provisions of the  Act (however, see
the Notes).

                                                            SEC 1746 (12-91)


<PAGE>2


                                       SCHEDULE 13D

- ------------------------------------
CUSIP No. 034602102
- ------------------------------------

   1    NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        Warburg, Pincus Ventures, L.P.          I.D. # 13-3784037
- --------------------------------------------------------------------------------
   2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)[x]

                                                                     (b)[ ]

- --------------------------------------------------------------------------------
   3    SEC USE ONLY

- --------------------------------------------------------------------------------
   4    SOURCE OF FUNDS*

            WC
- --------------------------------------------------------------------------------
   5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO
        ITEMS 2(d)or 2(e)                                                [ ]

- --------------------------------------------------------------------------------
   6    CITIZENSHIP OR PLACE OF ORGANIZATION

             Delaware
- --------------------------------------------------------------------------------
                 7    SOLE VOTING POWER
  NUMBER OF
    SHARES
 BENEFICIALLY                 0
   OWNED BY
     EACH      -----------------------------------------------------------------
  REPORTING      8    SHARED VOTING POWER
    PERSON
     WITH                  5,478,049
               -----------------------------------------------------------------
                 9    SOLE DISPOSITIVE POWER
                              0
               -----------------------------------------------------------------
                 10   SHARED DISPOSITIVE POWER

                           5,478,049

 -------------------------------------------------------------------------------
  11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

             5,478,049
- --------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*[ ]

- --------------------------------------------------------------------------------
  13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

             29.5%
- --------------------------------------------------------------------------------
  14    TYPE OF REPORTING PERSON*

             PN
- --------------------------------------------------------------------------------

                           *SEE INSTRUCTIONS BEFORE FILLING OUT!
               INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
           (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.


<PAGE>3


                                       SCHEDULE 13D

- -----------------------------------
CUSIP No. 034602102
- -----------------------------------

   1    NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        Warburg, Pincus & Co.          I.D. # 13-6358475
- --------------------------------------------------------------------------------
   2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) [X]

                                                                  (b) [ ]

- --------------------------------------------------------------------------------
   3    SEC USE ONLY

- --------------------------------------------------------------------------------
   4    SOURCE OF FUNDS*

            N/A
- --------------------------------------------------------------------------------
   5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO
        ITEMS 2(d)or 2(e)                                                [ ]
- --------------------------------------------------------------------------------
   6    CITIZENSHIP OR PLACE OF ORGANIZATION

            New York
- --------------------------------------------------------------------------------
                 7    SOLE VOTING POWER
  NUMBER OF
    SHARES                 0
 BENEFICIALLY
   OWNED BY     ----------------------------------------------------------------
     EACH        8    SHARED VOTING POWER
  REPORTING
    PERSON                 5,478,049
     WITH       ----------------------------------------------------------------
                 9    SOLE DISPOSITIVE POWER

                           0
                ----------------------------------------------------------------
                 10   SHARED DISPOSITIVE POWER

                            5,478,049

- --------------------------------------------------------------------------------
  11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

             5,478,049
- --------------------------------------------------------------------------------
  12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

        [ ]
- --------------------------------------------------------------------------------
  13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

             29.5%
- --------------------------------------------------------------------------------
  14    TYPE OF REPORTING PERSON*
             PN
- --------------------------------------------------------------------------------

                           *SEE INSTRUCTIONS BEFORE FILLING OUT!
               INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
           (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.


<PAGE>4

                                       SCHEDULE 13D

CUSIP No. 034602102
          ---------
- --------------------------------------------------------------------------------
   1    NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


        E.M. Warburg, Pincus & Company          I.D. # 13-3536050
- --------------------------------------------------------------------------------
   2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a) [X]

                                                                    (b) [ ]

- --------------------------------------------------------------------------------
   3    SEC USE ONLY

- --------------------------------------------------------------------------------
   4    SOURCE OF FUNDS*

            N/A
- --------------------------------------------------------------------------------
   5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO
        ITEMS 2(d) or 2(e)                                               [ ]

- --------------------------------------------------------------------------------
   6    CITIZENSHIP OR PLACE OF ORGANIZATION

            New York
- --------------------------------------------------------------------------------
                 7    SOLE VOTING POWER
  NUMBER OF
    SHARES                 0
 BENEFICIALLY
   OWNED BY      ---------------------------------------------------------------
     EACH         8    SHARED VOTING POWER
  REPORTING
    PERSON                  5,478,049
     WITH        ---------------------------------------------------------------
                  9    SOLE DISPOSITIVE POWER

                            0
                 ---------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER

                            5,478,049

- --------------------------------------------------------------------------------
  11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

             5,478,049
- --------------------------------------------------------------------------------
  12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
        [ ]
- --------------------------------------------------------------------------------
  13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

             29.5%
- --------------------------------------------------------------------------------
  14    TYPE OF REPORTING PERSON*
             PN
- --------------------------------------------------------------------------------

                           *SEE INSTRUCTIONS BEFORE FILLING OUT!
               INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
           (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.


<PAGE>5




       This Amendment No. 2 to Schedule 13D is being filed on behalf of Warburg,
Pincus Ventures,  L.P., a Delaware limited  partnership  ("Ventures"),  Warburg,
Pincus & Co., a New York general partnership ("WP"), and E.M. Warburg,  Pincus &
Company, a New York general partnership  ("EMW"),  relating to the Common Stock,
no par value (the "Common Stock"),  of Anergen,  Inc., a California  corporation
(the "Company").  Of the Reporting  Entities (defined below),  only Ventures has
acquired direct ownership of the Common Stock.

       This  Statement  amends  and  restates  the  Schedule  13D  filed  by the
Reporting  Entities on March 17, 1995,  and the Amendment No. 1 thereto filed by
the Reporting  Entities on April 18, 1995,  and is being filed  pursuant to Rule
13d-2 of the General Rules and Regulations under the Securities  Exchange Act of
1934 (the "Exchange Act").

Item 1.     Security and Issuer.
            -------------------

      This statement  relates to the Common Stock, no par value, of the Company.
The  principal  executive  offices of the Company  are located at 301  Penobscot
Drive, Redwood City, California 94063.

Item 2.     Identity and Background.
            -----------------------

      (a) This  statement  is filed by  Ventures,  WP and EMW.  The sole general
partner of Ventures is WP.  Lionel I. Pincus is the  managing  partner of WP and
may be deemed to control it. EMW manages Ventures.  WP has a 15% interest in the
profits of Ventures as the general partner,  and also owns approximately 1.5% of
the  limited  partnership  interests  in  Ventures.  Ventures,  WP and  EMW  are
hereinafter  collectively  referred to as the "Reporting  Entities." The general
partners of WP and EMW are described in Schedule I hereto.

       (b) The address of the principal business and principal office of each of
the Reporting Entities is 466 Lexington Avenue, New York, New York 10017.

       (c) The principal  business of Ventures is that of a partnership  engaged
in making venture capital and related investments.  The principal business of WP
is acting as general  partner  of  Ventures,  Warburg  Pincus  Investors,  L.P.,
Warburg,  Pincus Capital Company, L.P., Warburg,  Pincus Capital Partners,  L.P.
and Warburg, Pincus Associates, L.P., and as a holding company for its ownership
of securities of E.M. Warburg, Pincus & Co., Inc., a Delaware corporation ("E.M.
Warburg"),  the principal business of which is providing  specialized  financial
advisory and investment  counseling  services.  The principal business of EMW is
acting as manager of Ventures and Warburg, Pincus Investors, L.P.


<PAGE>6


       (d) None of the Reporting Entities,  nor, to the best of their knowledge,
any of the  directors,  executive  officers or general  partners  referred to in
paragraph  (a) has,  during the last five years,  been  convicted  in a criminal
proceeding (excluding traffic violations or similar misdemeanors).

       (e) None of the Reporting  Entities nor, to the best of their  knowledge,
any of the  directors,  executive  officers or general  partners  referred to in
paragraph  (a) above has,  during the last five  years,  been a party to a civil
proceeding of a judicial or administrative body of competent jurisdiction and as
a result of such  proceeding  was or is subject to a  judgment,  decree or final
order  enjoining  future  violations of, or prohibiting or mandating  activities
subject  to,  federal or state  securities  laws or finding any  violation  with
respect to such laws.

       (f) Except as  otherwise  indicated  on  Schedule  I hereto,  each of the
individuals referred to in paragraph (a) above is a United States citizen.

Item 3.     Source and Amount of Funds or Other Consideration.
            --------------------------------------------------

       The total amount of funds required by Ventures to purchase the Shares (as
defined  below),  pursuant to the  Purchase  Agreement  described in Item 4, was
$10,000,000.45, and was furnished from the working capital of Ventures.

      The total amount of funds  required by Ventures to purchase the Additional
Shares (as defined  below) was  $1,800,000,  and was furnished  from the working
capital of Ventures.

Item 4.     Purpose of Transaction.
            ----------------------

      On March 10,  1995,  the  Company  entered  into a Common  Stock  Purchase
Agreement   (the   "Purchase   Agreement")   with  Ventures  and   International
Biotechnology  Trust PLC ("IBT" and,  together with Ventures,  the "Purchasers")
pursuant to which Ventures agreed to purchase  4,878,049  shares of Common Stock
(the  "Shares")  for  an  aggregate   purchase  price  of  $10,000,000.45   (the
"Purchase") and IBT agreed to purchase  2,439,024  shares of Common Stock for an
aggregate purchase price of $4,999,999.20. The Purchase Agreement was amended by
a letter agreement dated March 15, 1995 (the "Letter Amendment"), confirming and
clarifying  the  obligation  of the  Purchasers to purchase the shares of Common
Stock. The shares of Common Stock are to be purchased pursuant to a registration
statement  (the  "Registration  Statement")  filed  by  the  Company  under  the
Securities Act of 1933, as amended (the  "Securities  Act"),  which was declared
effective by the Securities and Exchange Commission on February 14, 1995.



<PAGE>7


Pursuant to the Purchase Agreement, the Company agreed to issue the Shares
to the  Purchasers in  consideration  of the purchase  price and certain  rights
under the Purchase Agreement as described below.

      Registration Rights. Under the Purchase Agreement, the Purchasers have the
right (the "Requested Registration Right"), at any time after thirty (30) months
from the closing date (the "Closing Date") of the Purchase Agreement, to request
the Company to effect a registration (a "Registration  Request") of at least 30%
of the  aggregate  number  of  shares of  Common  Stock  held by the  requesting
Purchaser (the  "Initiating  Holder") or any lesser  percentage if the aggregate
net offering price would exceed $1,000,000.  The Company must give notice of the
proposed registration to all Purchasers and use its best efforts to register the
shares of the  Initiating  Holder and of any other  Purchaser  that provides the
Company a timely written request to be included in such registration.  If in the
good faith judgment of the Company's President the filing of such a registration
statement would be detrimental to the Company and its shareholders,  the Company
may defer such  registration  for up to 90 days,  provided  that the Company may
exercise this right only once in any 12-month period. If shares to be registered
are to be distributed by means of an underwriting, the underwriter may limit the
number of shares to be registered if in its judgment  marketing  factors require
such a cutback.  Ventures  is entitled to two (2) and IBT is entitled to one (1)
Registration  Request,  provided  that,  in  connection  with  such  request,  a
registration statement is declared effective and is not subsequently withdraw.

      In  addition,  in the event the Company  proposes  to register  any of its
securities for its own account or the account of any of its shareholders  (other
than  certain  registrations  including  a  registration  relating  solely to an
employee  benefit plan and certain  exchanges of securities with  shareholders),
the Purchasers have the right (the "Piggyback Registration Right") upon a timely
request to have their  shares  included  in such  registration.  If shares to be
registered are to be distributed by means of an  underwriting,  the  underwriter
may limit the  number  of  shares to be  registered  to not less than 25% of the
registration  if in its judgment  marketing  factors  require such a cutback.  A
Purchaser's  Requested  and Piggyback  Registration  Rights  terminate  upon the
earlier to occur (i) such time as the  Purchaser has disposed of all its shares,
or (ii) such time as all of  Purchaser's  shares may be sold in any  three-month
period  pursuant to Rule 144 under the Securities Act (without  giving effect to
Rule 144(k) thereunder).

      All  expenses  of  registration  must be  borne  by the  Company,  but all
underwriters'  fees,  discounts or  commissions  must be borne by the Purchasers
participating  in the  registration.  In  connection



<PAGE>8


with a  registration,  the Company  has agreed to  indemnify  the  participating
Purchasers for certain losses arising out of the registration  including losses
arising  out of or based upon any untrue  statement  of or omission of material
fact in the  registration  statement,  or arising out of any  violation  by the
Company of any rule or regulation  promulgated  under the Securities Act or any
state  securities  laws applicable to the Company or any failure by the Company
to fulfill any undertaking  included in the  registration  statement;  provided
that each such Purchaser  agrees to indemnify and hold harmless the Company and
any person who signs the  registration  statement for losses which arise out of
or are based upon any untrue  statement of or omission of material  fact in the
registration  statement which was made in reliance upon written statements from
such Purchaser. The Requested and Piggyback Registration Rights may be assigned
subject to certain  limitations.  The Company agreed to use its best efforts to
comply with the reporting and information requirements under Rule 144 which are
necessary   for  a  Purchaser  to  sell  its  shares  to  the  public   without
registration.

      Lock-up  Purchase  Agreements.  Pursuant  to the  terms  of  the  Purchase
Agreement,  each  Purchaser  will and each of Novo  Nordisk A/S,  Alpha  Venture
Partners III,  Crosspoint Venture Partners III, and  Hillman/Chesapeake  Limited
Partnership  has,  executed a lock-up  agreement in which it agrees not to sell,
make any short sale of,  loan,  grant any option for the  purchase  of, grant an
interest in, or otherwise  dispose of any shares of the Common Stock without the
prior  written  consent of the Company for a period of 180 days from the Closing
Date. These lock-up  agreements  terminate if the Closing Date does not occur by
April 30, 1995. The Company  expects the Closing Date will be immediately  after
shareholder approval is obtained.

     Board  Representation.  Under the Purchase  Agreement,  the Purchasers have
certain  rights of  representation  on the  Company's  Board of Directors as set
forth below:

      1. Until the  Purchaser  no longer holds the  required  minimum  number of
shares of Common Stock as provided  herein,  the Company must take all necessary
or desirable action within its control so that:

          a.The following  number of candidates of Ventures shall be included in
the slate of  nominees  recommended  by the  Company's  Board of  Directors  and
management at each election of directors:

                (1)  For so  long as  Ventures  holds  shares  of  Common  Stock
representing  at  least  22.5%  of the  issued  and  outstanding  shares  of the
Company's  Common Stock,  three (3) candidates  selected




<PAGE>9


by Ventures; provided, however, that so long as IBT continues to hold 2,439,024
shares  of  Common  Stock   (appropriately   adjusted  for  any  stock  splits,
consolidations,  or the  like),  no more  than two (2) such  nominees  shall be
employees of Ventures, and the third nominee shall be mutually agreed to by IBT
and Ventures; or

                 (2)  For so  long as  Ventures  hold  shares  of  Common  Stock
      representing  at  least  15%  but  less  than  22.5%  of  the  issued  and
      outstanding  shares of the  Company's  Common  Stock,  two (2)  candidates
      selected by Ventures; or

                 (3)  For so long as  Ventures  holds  shares  of  Common  Stock
      representing  more  than  7.5%  but  less  than  15%  of  the  issued  and
      outstanding  shares  of the  Company's  Common  Stock,  one (1)  candidate
      selected by Ventures.

          b.For so long as IBT  holds  shares of Common  Stock  representing  at
least 5% of the issued and outstanding shares of the Company's Common Stock, one
(1)  candidate  selected  by IBT  shall be  included  in the  slate of  nominees
recommended by the Company's  Board of Directors and management at each election
of directors.

      2. Until the  Purchaser  no longer holds the  required  minimum  number of
shares of Common Stock as provided above, the Company shall use its best efforts
to cause shares of Common Stock for which the  Company's  management or Board of
Directors holds proxies or is otherwise entitled to vote to be voted in favor of
the election of the designees of the Purchasers as provided above.

      3. Any  director  designated  by a  Purchaser  as  provided  above must be
removed from the Board (and  thereupon  from all committees of the Board) at the
written request of the Purchaser which has the right to designate such director,
but only upon such written request and under no circumstance except for cause as
provided by law.

      4. In the event that any  representative  designated by a Purchaser  above
for any reason ceases to serve as a member of the Board or any committee thereof
during such  representative's term of office, the resulting vacancy on the Board
or committee  must be filled by a  representative  designated  by the  Purchaser
which has the right to designate such a representative as provided above.

      The Company's obligations to a Purchaser as to the nomination of directors
and as to the election of such nominees as provided above  terminates  when such
Purchaser no longer holds the minimum  number of Shares as provided  above,  and
such  obligations  are not  transferable  to any  assignee  or  transferee  of a
Purchaser.


<PAGE>10


      Board Composition.  The Purchase Agreement provides that upon the  Closing
 Date, the Board of  Directors  shall consist  of eight members   including John
 W.  Fara,  Bruce L.A. Carter,   Harden M. McConnell,    Harry H.  Penner,  Jr.,
 William Cargile, James E.  Thomas,  Nicholas   J. Lowcock, and Nicole  Vitullo.
 James  E.   Thomas  and  Nicholas  J.     Lowcock   are   representatives    of
 Ventures;   Nicole Vitullo is a representative    of IBT.  After  the   Closing
 Date the Board  of Directors   must  appoint  one candidate   selected by   the
 mutual  agreement of Ventures and IBT  (as provided above).   Samuel Urcis  has
 agreed to resign  from the Board  of Directors  effective on the Closing   Date
 and William  Cargile   has agreed  to   resign from   the Board   of  Directors
 after six  (6) months from the Closing Date.

      Attendance at Shareholder  Meetings.  Under the Purchase  Agreement,  each
Purchaser, for so long as such Purchaser holds Shares representing at least five
percent (5%) of the voting power of the Company, agrees to be present, in person
or by proxy, at any duly called annual or special meeting of the shareholders of
the Company;  provided,  however, that such Purchaser has the right with respect
to each matter  presented  for voting to vote in any manner (or to abstain  from
voting  on  such  matter)  as  such  Purchaser  deems  appropriate  in its  sole
discretion,   except  that  such  Purchaser  agrees  to  provide  the  Company's
management  or the  Board  of  Directors  with a proxy  to vote in  favor of the
candidates for director nominated by such Purchaser as provided above.

      The  foregoing  description  of the  Purchase  Agreement  and  the  Letter
Amendment is  qualified in its entirety by reference to the Purchase  Agreement,
which is attached hereto as Exhibit 1 and is  incorporated  herein by reference,
and to the  Letter  Amendment,  which is  attached  hereto  as  Exhibit 2 and is
incorporated herein by reference.

      The purchase  was effected   because of  the Reporting   Entities'  belief
that the  Company   represents an  attractive   investment.   As a result of the
Purchase,  the   Reporting   Entities    will  become  the  Company's    largest
stockholders  and, hence, may be deemed to be "control persons."  Following  the
Purchase,  pursuant to the  terms   of the  Purchase  Agreement,  Mr.   Nicholas
J.  Lowcock,   who is affiliated  with E.M. Warburg,   and Mr. James  E. Thomas,
who is a  general partner of  WP and   EMW and a   Managing  Director   of  E.M.
Warburg,  will  serve  on the  Company's  Board of Directors as the nominees  of
Ventures.   Messrs.   Lowcock and  Thomas disclaim  beneficial ownership (within
the meaning of Rule 13d-3 under the  Exchange Act) of the Common Stock owned  by
Ventures.  The  Reporting Entities presently  expect to limit  their involvement
in the management of the Company to  representation  on the Board of Directors.



<PAGE>11


      The Reporting  Entities may from time to time acquire additional shares of
Common  Stock or  dispose  of shares  of Common  Stock  through  open  market or
privately  negotiated  transactions,  tender  offer or  otherwise,  depending on
existing  market  conditions  and  other  considerations  discussed  below.  The
Reporting  Entities  intend to  review  their  investment  in the  Company  on a
continuing  basis and,  depending upon the price and  availability  of shares of
Common  Stock,  subsequent  developments  affecting  the Company,  the Company's
business and prospects, other investment and business opportunities available to
the  Reporting  Entities,  general  stock  market and economic  conditions,  tax
considerations and other factors considered relevant, may decide at any time not
to increase, or to decrease, the size of their investment in the Company.

      Except as set forth  herein or in Item 6, none of the  Reporting  Entities
nor, to the best of their knowledge, any person listed in Schedule I hereto, has
any plans or proposals  which relate to or would result in: (a) the  acquisition
by any person of additional  securities of the Company,  or the  disposition  of
securities of the Company; (b) an extraordinary corporate transaction, such as a
merger,  reorganization  or  liquidation,  involving  the  Company or any of its
subsidiaries;  (c) a sale or  transfer  of a  material  amount  of assets of the
Company  or any of its  subsidiaries;  (d) any  change in the  present  Board of
Directors  or  management  of the Company,  including  any plans or proposals to
change the number or term of directors or to fill any existing  vacancies on the
board; (e) any material change in the present  capitalization or dividend policy
of the  Company;  (f) any other  material  change in the  Company's  business or
corporate  structure;   (g)  changes  in  the  Company's  charter,   By-Laws  or
instruments  corresponding  thereto  or  other  actions  which  may  impede  the
acquisition  of control of the  Company by any  person;  (h)  causing a class of
securities of the Company to be delisted from a national  securities exchange or
to cease to be authorized to be quoted in an inter-dealer  quotation system of a
registered national securities association;  (i) a class of equity securities of
the Company  becoming  eligible  for  termination  of  registration  pursuant to
Section  12(g)(4) of the Exchange Act; or (j) any action similar to any of those
enumerated above.

       On April 13, 1995, the Company's shareholders ratified the sale of Common
Stock pursuant to the Purchase  Agreement and approved the issuance of 7,317,073
shares of Common Stock at a per share price of $2.05 to the Purchasers.  Also on
April 13, 1995, the Closing Date, the transaction was consummated  subsequent to
the action of the shareholders.  As provided in the Purchase Agreement, Ventures
paid the agreed purchase price of  $10,000,000.45  and received the Shares,  and
IBT paid the agreed  purchase  price of  $4,999,999.20  and  received  2,439,024
shares of Common Stock.



<PAGE>12


      On August 9, 1996,  Ventures  purchased an  additional  600,000  shares
of Common  Stock (the  "Additional  Shares")  at a per share price of $3.00
(the "Additional Purchase") in connection with a public offering of Common
Stock by the Company.


Item 5.     Interest in Securities of the Issuer.
            -------------------------------------

       (a) Ventures  beneficially  owns  5,478,049  shares of Common  Stock.  By
reason of their respective  relationships  with Ventures,  each of the Reporting
Entities  may  be  deemed  under  Rule  13d-3  under  the  Exchange  Act  to own
beneficially all of the shares of Common Stock which Ventures beneficially owns.
Based  on  information  contained  in  Amendment    No.  1  to   the   Company's
 Registration Statement on Form S-1  (File  No.  333-07245),   filed  with   the
 Securities and  Exchange Commission  on August   9,   1996,   the   shares   of
 Common  Stock held by  the Reporting Entities represent approximately  29.5% of
the outstanding shares of Common Stock.

       (b) The Reporting  Entities together share the power to vote or to direct
the vote,  and to  dispose or to direct the  disposition  of the Shares  held by
them.

       (c) Except for the Additional Purchase,  none of the Reporting  Entities
nor, to the best of their  knowledge,  any person listed in Schedule I hereto,
has effected any transactions in the Common Stock during the preceding 60 days.

       (d)  Except  as set  forth in this  Item 5, no  person  other  than  each
respective  record owner  referred to herein of  securities is known to have the
right to receive or the power to direct the receipt of  dividends  from,  or the
proceeds from the sale of, such securities.

       (e)  Not applicable.

Item 6.     Contracts,  Arrangements,  Understandings  or  Relationships  with
            Respect  to  Securities  of  the Issuer.
            -------------------------------------------------------------------

      Pursuant  to  Rule  13d-1(f)  promulgated  under  the  Exchange  Act,  the
Reporting  Persons  have  entered  into an  agreement  with respect to the joint
filing of this  statement,  and any  amendment or  amendments  hereto,  which is
attached hereto as Exhibit 3 and is incorporated herein by reference.

      As  described  in Item 4, the  Purchasers  and the  Company  have  agreed,
pursuant  to  the  Purchase   Agreement,   to  certain  terms  with  respect  to
registration  and sale of  shares  of the  Common  Stock,  as well as  rights of
representation  on the Company's  Board of  Directors,  the  composition  of the
Company's  Board of Directors,  and  attendance  at  shareholder  meetings.  The
information set forth in Item 4 above is incorporated herein by reference.



<PAGE>13


      Except as described herein and by reference to Item 4 above,  there are no
contracts, arrangements, understandings or relationships among the persons named
in Item 2 or between  such  persons  and any other  person  with  respect to any
securities of the Company.

      By virtue of the relationships  among the Reporting  Entities as described
in Item 2, the  Reporting  Entities  may be  deemed  to be a  "group"  under the
Federal securities laws. Lionel I. Pincus disclaims any beneficial  ownership of
the  Shares  reported  herein  as  being  beneficially  owned  by the  Reporting
Entities.

Item 7.     Material to be Filed as Exhibits.

Exhibit 1         Purchase Agreement,  dated March 10, 1995, between Anergen,
                  Inc. and Warburg,  Pincus Ventures, L.P. and International
                  Biotechnology Trust PLC.*

Exhibit 2         Letter  Amendment  to Purchase  Agreement,  dated March 15,
                  1995,  between  Anergen,  Inc.  and Warburg, Pincus Ventures,
                  L.P. and International Biotechnology Trust PLC.*

Exhibit 3         Joint Filing Agreement.*



- ------------------
* Filed as exhibits to the initially filed paper format Schedule 13D, filed with
the  Securities  and Exchange  Commission  on March 17, 1995.  Pursuant to Rule
13d-2(e)  under the Exchange  Act, such exhibits are not required to be restated
electronically.

<PAGE>14

                                   SIGNATURE
                                   ---------

       After  reasonable  inquiry and to the best of my knowledge and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.

Dated: August 15, 1996



                           WARBURG, PINCUS VENTURES, L.P.
                           BY:  Warburg, Pincus & Co., General Partner


                           /s/ Stephen Distler
                           -----------------------------
                           By:  Stephen Distler, Partner




                          WARBURG, PINCUS & CO.


                          /s/ Stephen Distler
                         -----------------------------
                          By:  Stephen Distler, Partner



                          E.M. WARBURG, PINCUS & COMPANY


                          /s/ Stephen Distler
                         -----------------------------
                          By:  Stephen Distler, Partner



<PAGE>15


                                                                   SCHEDULE I


     Set forth below is the name,  position and present principal  occupation of
each of the general partners of Warburg,  Pincus & Co. ("WP") and E.M.  Warburg,
Pincus & Company ("EMW"). The sole general partner of Warburg,  Pincus Ventures,
L.P.  ("Ventures")  is WP. WP, EMW and  Ventures  are  hereinafter  collectively
referred to as the  "Reporting  Entities."  Except as otherwise  indicated,  the
business address of each of such persons is 466 Lexington Avenue,  New York, New
York 10017, and each of such persons is a citizen of the United States.


                                General Partners
                                      of WP
                                      -----

                                       Present Principal Occupation
                                       in Addition to Position With
                                       WP, and Positions with the
Name                                   Reporting Entities
- ----                                   -----------------------------

Susan Black                            Partner, EMW; Managing Director, E.M.
                                       Warburg, Pincus & Co., Inc. ("E.M.
                                       Warburg"), a Delaware corporation and
                                       wholly-owned subsidiary of WP

Christopher W. Brody                   Partner, EMW; Managing Director, E.M.
                                       Warburg

Harold Brown                           Partner, EMW; Senior Managing
                                       Director, E.M. Warburg

Errol M. Cook                          Partner, EMW; Managing Director, E.M.
                                       Warburg

W. Bowman Cutter                       Partner, EMW; Managing Director, E.M.
                                       Warburg

Elizabeth B. Dater                     Partner, EMW; Managing Director, E.M.
                                       Warburg

Stephen Distler                        Partner, EMW; Managing Director and
                                       Controller, E.M. Warburg

Louis G. Elson                         Partner, EMW; Managing Director, E.M.
                                       Warburg


John L. Furth                          Partner, EMW; Vice Chairman of the
                                       Board, E.M. Warburg

Stuart M. Goode                        Partner, EMW; Managing Director, E.M.
                                       Warburg

Stewart K.P. Gross                     Partner, EMW; Managing Director, E.M.
                                       Warburg

Patrick T. Hackett                     Partner, EMW; Managing Director, E.M.
                                       Warburg

Jeffrey A. Harris                      Partner, EMW; Managing Director, E.M.
                                       Warburg

Robert S. Hillas                       Partner, EMW; Managing Director, E.M.
                                       Warburg

A. Michael Hoffman                     Partner, EMW; Managing Director, E.M.
                                       Warburg

William H. Janeway                     Partner, EMW; Managing Director, E.M.
                                       Warburg

Douglas M. Karp                        Partner, EMW; Managing Director, E.M.
                                       Warburg

Charles R. Kaye                        Partner, EMW; Managing Director, E.M.
                                       Warburg
<PAGE>16



Henry Kressel                          Partner, EMW; Managing Director, E.M.
                                       Warburg

Joseph P. Landy                        Partner, EMW; Managing Director, E.M.
                                       Warburg

Sidney Lapidus                         Partner, EMW; Managing Director, E.M.
                                       Warburg

Reuben S. Leibowitz                    Partner, EMW; Managing Director, E.M.
                                       Warburg

Stephen J. Lurito                      Partner, EMW; Managing Director, E.M.
                                       Warburg

Spencer S. Marsh III                   Partner, EMW; Managing Director, E.M.
                                       Warburg

Edward J. McKinley                     Partner, EMW; Managing Director, E.M.
                                       Warburg

Rodman W. Moorhead III                 Partner, EMW; Senior Managing
                                       Director, E.M. Warburg

Howard H. Newman                       Partner, EMW; Managing Director, E.M.
                                       Warburg

Anthony G. Orphanos                    Partner, EMW; Managing Director, E.M.
                                       Warburg

Daphne D. Philipson                    Partner, EMW; Managing Director, E.M.
                                       Warburg

Lionel I. Pincus                       Managing Partner, EMW; Chairman of the
                                       Board and CEO, E.M. Warburg; Managing
                                       Partner, Pincus & Co.

Eugene L. Podsiadlo                    Partner, EMW; Managing Director, E.M.
                                       Warburg

Ernest H. Pomerantz                    Partner, EMW; Managing Director, E.M.
                                       Warburg

Arnold M. Reichman                     Partner, EMW; Managing Director, E.M.
                                       Warburg

Roger Reinlieb                         Partner, EMW; Managing Director, E.M.
                                       Warburg



<PAGE>17

John D. Santoleri                      Partner, EMW; Managing Director, E.M.
                                       Warburg

Sheila N. Scott                        Partner, EMW; Managing Director, E.M.
                                       Warburg

Peter Stalker III                      Partner, EMW; Managing Director, E.M.
                                       Warburg

David A. Tanner                        Partner, EMW; Managing Director, E.M.
                                       Warburg

James E. Thomas                        Partner, EMW; Managing Director, E.M.
                                       Warburg

John L. Vogelstein                     Partner, EMW; Vice Chairman of the
                                       Board, E.M. Warburg

Elizabeth H. Weatherman                Partner, EMW; Managing Director, E.M.
                                       Warburg

Joanne R. Wenig                        Partner, EMW; Managing Director, E.M.
                                       Warburg

George U. Wyper                        Partner, EMW; Managing Director, E.M.
                                       Warburg

Pincus & Co.*

NL & Co.**

- -------------------------------
*    New York limited partnership; primary activity is ownership interest in
     WP and EMW.

**   New York limited partnership; primary activity is ownership interest in
     WP and EMW.





<PAGE>18


                                General Partners
                                     of EMW


                                             Present Principal Occupation
                                             in Addition to Position with
                                             EMW, and Positions with the
Name                                         Reporting Entities
- ----                                         ----------------------------

Susan Black                               Partner, WP; Managing Director, E.M.
                                          Warburg

Christopher W. Brody                      Partner, WP; Managing Director, E.M.
                                          Warburg

Harold Brown                              Partner, WP; Senior Managing
                                          Director, E.M. Warburg

Dale C. Christensen(1)                    Managing Director, E.M. Warburg

Errol M. Cook                             Partner, WP; Managing Director, E.M.
                                          Warburg

W. Bowman Cutter                          Partner, WP; Managing Director,
                                          E.M.  Warburg

Elizabeth B. Dater                        Partner, WP; Managing Director, E.M.
                                          Warburg

Stephen Distler                           Partner, WP; Managing Director and
                                          Controller, E.M. Warburg

Louis G. Elson                            Partner, WP; Managing Director, E.M.
                                          Warburg

John L. Furth                             Partner, WP; Vice Chairman of the
                                          Board, E.M. Warburg

Stuart M. Goode                           Partner, WP; Managing Director, E.M.
                                          Warburg

Stewart K.P. Gross                        Partner, WP; Managing Director, E.M.
                                          Warburg

Patrick T. Hackett                        Partner, WP; Managing Director, E.M.
                                          Warburg

Jeffrey A. Harris                         Partner, WP; Managing Director, E.M.
                                          Warburg

Robert S. Hillas                          Partner, WP; Managing Director, E.M.
                                          Warburg
- --------------------------------
(1)  Citizen of Canada.



<PAGE>20



A. Michael Hoffman                       Partner, WP; Managing Director, E.M.
                                         Warburg

William H. Janeway                       Partner, WP; Managing Director, E.M.
                                         Warburg

Douglas M. Karp                          Partner, WP; Managing Director, E.M.
                                         Warburg

Charles R. Kaye                          Partner, WP; Managing Director, E.M.
                                         Warburg

Richard H. King(2)                       Managing Director, E.M. Warburg

Henry Kressel                            Partner, WP; Managing Director, E.M.
                                         Warburg

Joseph P. Landy                          Partner, WP; Managing Director, E.M.
                                         Warburg

Sidney Lapidus                           Partner, WP; Managing Director, E.M.
                                         Warburg

Reuben S. Leibowitz                      Partner, WP; Managing Director, E.M.
                                         Warburg

Stephen J. Lurito                        Partner, WP; Managing Director, E.M.
                                         Warburg

Spencer S. Marsh III                     Partner, WP; Managing Director, E.M.
                                         Warburg

Edward J. McKinley                       Partner, WP; Managing Director, E.M.
                                         Warburg

Rodman W. Moorhead III                   Partner, WP; Senior Managing Director,
                                         E.M. Warburg

Howard H. Newman                         Partner, WP; Managing Director, E.M.
                                         Warburg

Anthony G. Orphanos                      Partner, WP; Managing Director, E.M.
                                         Warburg

Dalip Pathak(3)                          Managing Director, E.M. Warburg

- ------------------------------
(2)   Citizen of United Kingdom.

(3)   Citizen of India.

<PAGE>21


Daphne D. Philipson                      Partner, WP; Managing Director,
                                         E.M.  Warburg

Lionel I. Pincus                         Managing  Partner,  WP;  Chairman
                                         of  the Board  and  CEO,  E.M.
                                         Warburg; Managing Partner, Pincus
                                         & Co.

Eugene L. Podsiadlo                      Partner, WP; Managing Director, E.M.
                                         Warburg

Ernest H. Pomerantz                      Partner, WP; Managing Director, E.M.
                                         Warburg

Arnold M. Reichman                       Partner, WP; Managing Director, E.M.
                                         Warburg

Roger Reinlieb                           Partner, WP; Managing Director, E.M.
                                         Warburg

John D. Santoleri                        Partner, WP; Managing Director,
                                         E.M.  Warburg


Sheila N. Scott                          Partner, WP; Managing Director, E.M.
                                         Warburg

Dominic H. Shorthouse(2)                 Managing Director, E.M. Warburg

Peter Stalker III                        Partner, WP; Managing Director, E.M.
                                         Warburg

David A. Tanner                          Partner, WP; Managing Director, E.M.
                                         Warburg

James E. Thomas                          Partner, WP; Managing Director, E.M.
                                         Warburg

John L. Vogelstein                       Partner, WP; Vice Chairman of the
                                         Board, E.M. Warburg

Elizabeth H. Weatherman                  Partner, WP; Managing Director,
                                         E.M.  Warburg

Joanne R. Wenig                          Partner, WP; Managing Director, E.M.
                                         Warburg

George U. Wyper                          Partner, WP; Managing Director, E.M.
                                         Warburg

Pincus & Co.*

- ---------------------------------
(2)   Citizen of United Kingdom.

*     New York limited partnership; primary activity is ownership interest in
      WP and EMW.




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