ANERGEN INC
DEF 14A, 1998-04-06
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>   1
 
                            SCHEDULE 14A INFORMATION
                  Proxy Statement Pursuant to Section 14(a) of
              the Securities Exchange Act of 1934 (Amendment No. )
 
Filed by the Registrant [X]
Filed by a party other than the Registrant [ ]
Check the appropriate box:
[ ] Preliminary Proxy Statement
[ ] Confidential, for Use of the Commission Only (as permitted by Rule
14a-6(e)(2))
[X] Definitive Proxy Statement
[X] Definitive Additional Materials
[ ] Soliciting Material Pursuant to 240.14a-11(c) or 240.14a-12
 
                                 ANERGEN, INC.
                (Name of Registrant as Specified In Its Charter)
                            ------------------------
 
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)
 
Payment of Filing Fee (Check the appropriate box):
[X] No fee required.
[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11
    (1) Title of each class of securities to which transaction applies:
    (2) Aggregate number of securities to which transaction applies:
    (3) Per unit price or other underlying value of transaction computed
        pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
        filing fee is calculated and state how it was determined):
   (4) Proposed maximum aggregate value of transaction:
   (5) Total fee paid:
[ ] Fee paid previously with preliminary materials.
[ ] Check box if any part of the fee is offset as provided by Exchange Act Rule
    0-11(a)(2) and identify the filing for which the offsetting fee was paid
    previously. Identify the previous filing by registration statement number,
    or the Form or Schedule and the date of its filing.
    (1) Amount Previously Paid:
    (2) Form, Schedule or Registration Statement No.:
    (3) Filing Party:
    (4) Date Filed:
<PAGE>   2
 
                                 ANERGEN, INC.
                            ------------------------
                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                          TO BE HELD ON APRIL 29, 1998
 
TO THE SHAREHOLDERS:
 
     NOTICE IS HEREBY GIVEN that the Annual Meeting of Shareholders of Anergen,
Inc. (the "Company") will be held on Wednesday, April 29, 1998 at 10:00 a.m.,
local time, at the Company's offices at 301 Penobscot Drive, Redwood City,
California 94063 for the following purposes:
 
     1. To elect seven directors to serve for one year and until their
        successors are duly elected.
 
     2. To approve an amendment to the Company's 1991 Employee Stock Purchase
        Plan increasing the number of shares of Common Stock reserved for
        issuance by 500,000 shares.
 
     3. To approve an amendment to the Company's 1996 Stock Plan increasing the
        number of shares of Common Stock reserved for issuance by 1,000,000
        shares.
 
     4. To approve a change in the state of incorporation of the Company from
        the State of California to the State of Delaware by means of a merger of
        the Company with and into a wholly-owned Delaware subsidiary.
 
     5. To approve the form of indemnification agreement to be entered into
        between the Company and its directors and officers in connection with
        the proposed reincorporation.
 
     6. To approve an amendment to the Company's Amended and Restated Articles
        of Incorporation to effect a reverse split of the Company's Common
        Stock.
 
     7. To approve an amendment to the Company's Amended and Restated Articles
        of Incorporation increasing the authorized number of shares of Common
        Stock of the Company from 40,000,000 shares to 60,000,000 shares.
 
     8. To confirm the appointment of Ernst & Young LLP as independent auditors
        for the fiscal year ending December 31, 1998.
 
     9. To transact such other business as may properly come before the meeting
        or any adjournment thereof.
 
     Only shareholders of record at the close of business on March 20, 1998 are
entitled to notice of and to vote at the meeting.
 
     All shareholders are cordially invited to attend the meeting in person.
However, to assure your representation at the meeting, you are urged to sign and
return the enclosed proxy as promptly as possible in the postage-prepaid
envelope enclosed for that purpose. Any shareholder attending the meeting may
vote in person even if he has returned a proxy.
 
                                          By order of the Board of Directors
 
                                          Barry M. Sherman, M.D.
                                          President and Chief Executive Officer
Redwood City, California
April 7, 1998
<PAGE>   3
 
                                 ANERGEN, INC.
                            ------------------------
 
                              PROXY STATEMENT FOR
                      1998 ANNUAL MEETING OF SHAREHOLDERS
                            ------------------------
                 INFORMATION CONCERNING SOLICITATION AND VOTING
 
GENERAL
 
     The enclosed Proxy is solicited on behalf of the Board of Directors of
Anergen, Inc. (the "Company") for use at the Annual Meeting of Shareholders to
be held on Wednesday, April 29, 1998, at 10:00 a.m., local time, or at any
adjournment thereof, for the purposes set forth herein and in the accompanying
Notice of Annual Meeting of Shareholders. The Annual Meeting will be held at the
Company's principal offices at 301 Penobscot Drive, Redwood City, California
94063.
 
     These proxy solicitation materials were mailed on or about April 7, 1998 to
all shareholders entitled to vote at the meeting.
 
RECORD DATE AND PRINCIPAL SHARE OWNERSHIP
 
     Shareholders of record at the close of business on March 20, 1998 (the
"Record Date") are entitled to notice of the meeting and to vote at the meeting.
The Company has only one class of stock outstanding designated as Common Stock.
As of the Record Date, 18,851,000 shares of the Company's Common Stock were
issued and outstanding and held of record by approximately 319 shareholders and
were beneficially owned by over 4,700 shareholders.
<PAGE>   4
 
     The following table sets forth certain information regarding the beneficial
ownership as of February 28, 1998 of the Company's Common Stock as to (i) each
person who is known to the Company to beneficially own more than five percent of
the outstanding shares of its Common Stock, (ii) each director, (iii) each
executive officer named in the Summary Compensation Table below and (iv) all
directors and executive officers as a group:
 
<TABLE>
<CAPTION>
                                                              NO. OF SHARES
                                                              BENEFICIALLY
                          NAME(1)                                 OWNED       PERCENTAGE(2)
                          -------                             -------------   -------------
<S>                                                           <C>             <C>
Warburg, Pincus Ventures, L.P.(3)...........................    5,478,049          29.1%
  466 Lexington Avenue
  New York, NY 10017
International Biotechnology Trust PLC.......................    2,439,024          12.9%
  Five Arrows House
  St. Swithin's Lane
  London, EC4N 8NR
  England
Novo Nordisk A/S............................................    1,219,745           6.5%
  Novo Alle
  2880 Basgvaerd
  Denmark
Wellington Management Company LLP...........................      994,000           5.3%
  75 State Street
  Boston, MA 02109
Pioneering Management Corporation...........................      830,000           4.4%
  60 State Street
  Boston, MA 02109
Barry M. Sherman, M.D.(4)...................................      193,970             *
David V. Smith(5)...........................................       15,620             *
John W. Varian(6)...........................................      117,500             *
Jeffrey L. Winkelhake, Ph.D.(7).............................       94,844             *
Michael G. Shulman, M.D.(8).................................       15,630             *
Gilbert R. Mintz, Ph.D.(9)..................................       13,546             *
Bruce L.A. Carter, Ph.D.(10)................................    1,219,745           6.5%
Harden M. McConnell, Ph.D.(11)..............................       31,976             *
Harry H. Penner, Jr.(12)....................................       33,010             *
James E. Thomas(13).........................................    5,478,049          29.1%
Nicholas J. Lowcock(14).....................................            0             *
Nicole Vitullo(15)..........................................            0             *
All directors and executive officers as a group (13
  persons)(16)..............................................    7,225,562         37.48%
</TABLE>
 
- ---------------
  *  Represents less than 1% of the outstanding Common Stock.
 
 (1) The persons named in the table, to the Company's knowledge, have sole
     voting and investment power with respect to all shares of Common Stock
     shown as beneficially owned by them, subject to community property laws
     where applicable and the information contained in the footnotes hereunder.
 
 (2) Applicable percentage of ownership is based on 18,851,000 shares of Common
     Stock outstanding as of February 28, 1998, together with applicable options
     and warrants held by such shareholder. Beneficial ownership is determined
     in accordance with the rules of the Securities and Exchange Commission, and
     includes voting and investment power with respect to shares. Shares of
     Common Stock subject to options exercisable within 60 days of February 28,
     1998 are deemed outstanding for computing the percentage ownership of the
     person holding such options, but are not deemed outstanding for computing
     the percentage ownership of any other person.
 
 (3) The sole general partner of Warburg, Pincus Ventures, L.P. ("Ventures") is
     Warburg, Pincus & Co., a New York general partnership ("WP"). E.M. Warburg,
     Pincus & Co., LLC, a New York limited
 
                                        2
<PAGE>   5
 
     liability company ("EMW LLC"), manages Ventures. The members of EMW LLC are
     substantially the same as the partners of WP. Lionel I. Pincus is the
     managing partner of WP and the managing member of EMW LLC and may be deemed
     to control both WP and EMW LLC. WP has a 15% interest in the profits of
     Ventures as the general partner and also owns approximately 1.3% of the
     limited partnership interests in Ventures.
 
 (4) Includes 191,661 shares subject to options exercisable within 60 days of
     February 28, 1998.
 
 (5) Includes 15,620 shares subject to options exercisable within 60 days of
     February 28, 1998.
 
 (6) Includes 117,500 shares subject to options exercisable within 60 days of
     February 28, 1998.
 
 (7) Includes 94,482 shares subject to options exercisable within 60 days of
     February 28, 1998.
 
 (8) Includes 15,630 shares subject to options exercisable within 60 days of
     February 28, 1998.
 
 (9) Includes 13,546 shares subject to options exercisable within 60 days of
     February 28, 1998.
 
(10) Represents 1,219,745 shares held by Novo Nordisk A/S, of which Dr. Carter
     is an executive officer. Dr. Carter disclaims beneficial ownership of these
     shares.
 
(11) Includes 31,978 shares subject to options exercisable within 60 days of
     February 28, 1998.
 
(12) Includes 33,010 shares subject to options exercisable within 60 days of
     February 28, 1998.
 
(13) All of the shares indicated as owned by Mr. Thomas are owned directly by
     Ventures and are included because of Mr. Thomas' affiliation with Ventures.
     Mr. Thomas, a director of the Company, is a Managing Director of EMW LLC
     and a general partner of WP. As such, Mr. Thomas may be deemed to have an
     indirect pecuniary interest (within the meaning of Rule 16a-1 under the
     Securities Exchange Act of 1934) in an indeterminate portion of the shares
     beneficially owned by Ventures and WP. Mr. Thomas disclaims "beneficial
     ownership" of these shares within the meaning of Rule 13d-3 under the
     Securities Exchange Act of 1934.
 
(14) Does not include shares held by Ventures. Mr. Lowcock is employed by EMW
     LLC and is a director of the Company. Mr. Lowcock disclaims beneficial
     ownership of the shares held by Ventures and WP.
 
(15) Does not include shares held by International Biotechnology Trust PLC
     ("IBT"). Ms. Vitullo, a director of the Company, is an employee of
     Rothschild, Inc., a corporation affiliated with Rothschild Asset
     Management, Ltd., investment manager for International Biotechnology Trust
     PLC. Ms. Vitullo disclaims beneficial ownership of the shares held by IBT.
 
(16) Includes 428,219 shares subject to options exercisable within 60 days of
     February 28, 1998. Reflects the shares of Ventures of which Mr. Thomas may
     be deemed to have an indirect pecuniary interest (within the meaning of
     Rule 16a-1 of the Securities Exchange Act of 1934) and the shares of Novo
     Nordisk A/S of which Dr. Carter is an executive officer. Does not reflect
     beneficial ownership of Mr. Lowcock of Ventures and Ms. Vitullo of IBT who
     do not have beneficial ownership of the shares of such entities,
     respectively.
 
REVOCABILITY OF PROXIES
 
     Any proxy given pursuant to this solicitation may be revoked by the person
giving it at any time before its use by delivering to the Secretary of the
Company a written notice of revocation or a duly executed proxy bearing a later
date or by attending the meeting and voting in person.
 
VOTING AND SOLICITATION
 
     Each shareholder is entitled to one vote for each share held. Each
shareholder may vote on the proposals described herein by proxy or by attending
the meeting and voting in person. Shareholders may not cumulate their votes in
the election of directors. The security represented by proxy will be voted, and
when a choice is specified by a shareholder in the proxy, the security will be
voted in accordance with that choice.
 
     This solicitation of proxies is made by the Company, and all related costs
will be borne by the Company. In addition, the Company may reimburse brokerage
firms and other persons representing beneficial owners of shares for their
expenses in forwarding solicitation material to such beneficial owners. Original
solicitation of
 
                                        3
<PAGE>   6
 
proxies by mail may be supplemented by telephone, telegraph or personal
solicitations by directors, officers or employees of the Company. No additional
compensation will be paid for any such services.
 
DEADLINE FOR RECEIPT OF SHAREHOLDER PROPOSALS
 
     Proposals of shareholders of the Company that are intended to be presented
by such shareholders at the Company's 1999 Annual Meeting of Shareholders must
have been received by the Company no later than November 30, 1998 in order that
they may be considered for inclusion in the proxy statement and form of proxy
relating to that meeting.
 
VOTE REQUIRED
 
     In order to be validly approved by the shareholders, Proposals 1, 2, 3, 5
and 8 described herein must be approved by the affirmative vote of a majority of
the shares represented and voting at the meeting at which a quorum is present.
Proposals 4, 6 and 7 described herein must be approved by a majority of the
outstanding shares of Common Stock entitled to vote. A majority of shares
entitled to vote, in person or by proxy, constitute the number of shares
necessary for a quorum for any meeting of shareholders. Abstentions for any
particular proposal are counted for purposes of determining the presence or
absence of a quorum. Abstentions and shares held by brokers that are present but
not voted because the brokers were prohibited from exercising discretionary
authority ("broker non-votes") will be counted as present for the purpose of
determining if a quorum is present, but will not otherwise be counted as voting
for or against a proposal.
 
                                        4
<PAGE>   7
 
                                 PROPOSAL NO. 1
 
                             ELECTION OF DIRECTORS
 
NOMINEES
 
     A board of seven (7) directors is to be elected at the Annual Meeting of
Shareholders. Unless otherwise instructed, the proxy holders will vote the
proxies received by them for the Company's nominees named below, all of whom are
presently directors of the Company. In the event that any nominee of the Company
is unable or declines to serve as a director at the time of the Annual Meeting
of Shareholders, the proxies will be voted for any nominee who shall be
designated by the present Board of Directors to fill the vacancy. It is not
expected that any nominee will be unable or will decline to serve as a director.
In the event that additional persons are nominated for election as directors,
the proxy holders intend to vote all proxies received by them in such a manner
as will assure the election of as many of the nominees listed below as possible,
and in such event the specific nominees to be voted for will be determined by
the proxy holders. The term of office of each person elected as a director will
continue until the next Annual Meeting of Shareholders or until a successor has
been elected.
 
     The nominees and certain information about them are set forth below:
 
<TABLE>
<CAPTION>
                                                                                       DIRECTOR
      NAME AND NOMINEE         AGE                     POSITION(S)                      SINCE
      ----------------         ---                     -----------                     --------
<S>                            <C>   <C>                                               <C>
Barry M. Sherman, M.D          56    President, Chief Executive Officer, and Director    1996
Bruce L. A. Carter, Ph.D       54    Director                                            1994
Nicholas J. Lowcock            34    Director                                            1995
Harden M. McConnell, Ph.D      70    Director                                            1989
Harry H. Penner, Jr.           52    Director                                            1993
James E. Thomas                38    Director                                            1995
Nicole Vitullo                 40    Director                                            1995
</TABLE>
 
     BARRY M. SHERMAN, M.D., joined the Company as President and Chief Executive
Officer and as a director in May 1996. Dr. Sherman previously served as Senior
Vice President and Chief Medical Officer at Genentech, Inc. ("Genentech"), a
biotechnology company. Dr. Sherman joined Genentech in 1985, and while there
served as a member of the Operations Committee and was responsible for the
Company's overall clinical development activities. Since 1986, Dr. Sherman has
also been a Clinical Professor of Internal Medicine at Stanford University. From
1971 to 1985, Dr. Sherman was a Professor of Internal Medicine, Director of the
Clinical Research Center and Associate Chairman of the Department of Internal
Medicine at the University of Iowa College of Medicine. Dr. Sherman received his
M.D. in 1966 from the University of Michigan. Dr. Sherman currently serves on
the board of directors of Chrysalis International Corporation and Celtrix
Pharmaceuticals, Inc.
 
     BRUCE L.A. CARTER, PH.D., has served as a director of the Company since
February 1994. Since 1994, Dr. Carter has served as Corporate Executive Vice
President and Chief Scientific Officer of Novo Nordisk A/S ("Novo Nordisk"), a
pharmaceutical and bio-industrial company. From 1988 to 1995, Dr. Carter served
as president of ZymoGenetics, Inc., a biotechnology company that is a subsidiary
of Novo Nordisk, and has served as Chairman of this company since 1994. Dr.
Carter was nominated to the Board of Directors in accordance with rights held by
Novo Nordisk pursuant to an equity agreement described below under "Compensation
Committee Interlocks and Insider Participation."
 
     NICHOLAS J. LOWCOCK has served as a director of the Company since April
1995. Since August 1994 he has been employed by E. M. Warburg, Pincus & Co.,
LLC, a specialized private equity firm (or its predecessors), where he currently
serves as Vice President. Prior to August, 1994, Mr. Lowcock was a consultant
with The Boston Consulting Group. Mr. Lowcock was nominated to the Board of
Directors in accordance with rights held by Warburg, Pincus Ventures, L.P.
pursuant to an equity agreement described below under "Certain Relationships and
Related Transactions." Mr. Lowcock is also a director of Scientific Learning
Corp. and The Medicines Company, Inc.
 
                                        5
<PAGE>   8
 
     HARDEN M. MCCONNELL, PH.D., has served as a director of the Company since
May 1989. Dr. McConnell has been a Professor of Chemistry at Stanford University
since 1964. He is also a member of the Company's Scientific Advisory Board. Dr.
McConnell serves on the board of directors of Molecular Devices Corporation.
 
     HARRY H. PENNER, JR. has served as a director of the Company since August
1993. Since December of 1993 he has been President/CEO and director of Neurogen
Corporation, a neuropharmaceutical company. From 1985 to December 1993, he was
Executive Vice President of Novo Nordisk and, beginning in 1988, President of
Novo Nordisk of North America, a subsidiary of Novo Nordisk. Mr. Penner is also
a director of T Cell Sciences Inc.
 
     JAMES E. THOMAS has served as a director of the Company since April 1995.
Since 1989, he has been employed by E.M. Warburg, Pincus & Co., LLC, a
specialized private equity firm (or its predecessors), where he currently serves
as Managing Director. Prior to 1989, Mr. Thomas was a Vice President of Goldman
Sachs International in London. Mr. Thomas was nominated to the Board of
Directors in accordance with rights held by Warburg, Pincus Ventures, L.P.
pursuant to an equity agreement described below under "Certain Relationships and
Related Transactions." Mr. Thomas is also a director of Celtrix Pharmaceuticals,
Inc., Menley & James Laboratories, Inc., Xomed Surgical Products, Inc.,
Transkaryotic Therapies, Inc., Oxford GlycoSciences plc and a number of
privately held companies.
 
     NICOLE VITULLO has served as a director of the Company since April 1995.
Ms. Vitullo is Senior Vice President of Rothschild Asset Management, Ltd., a
manager of two publicly traded biotechnology funds, Biotechnology Investments
Limited and International Biotechnology Trust PLC. Prior to joining Rothschild
in 1992, Ms. Vitullo was a Director of Corporate Communications and Investor
Relations at Cephalon, Inc., a neuropharmaceutical company. Prior to 1992, Ms.
Vitullo was Manager of Healthcare Investments for Eastman Kodak, Co. Ms. Vitullo
was nominated to the Board of Directors in accordance with rights held by
International Biotechnology Trust PLC pursuant to an equity agreement described
below under "Certain Relationships and Related Transactions." Ms. Vitullo is
also a director of Cadus Pharmaceuticals Corporation, Cytel Corporation, Onyx
Pharmaceuticals Inc. and Corvas International.
 
     There are no family relationships among the directors of the Company.
 
REQUIRED VOTE
 
     The seven nominees receiving the highest number of affirmative votes cast
shall be elected as directors.
 
BOARD MEETINGS AND COMMITTEES
 
     The Board of Directors held a total of five meetings and took no action by
written consent in 1997. The Audit Committee held two meetings and took no
action by written consent in 1997. The Compensation Committee held one meeting
and took no action by written consent in 1997. Each director attended at least
75% of the Board meetings held during 1997 and, where applicable, the Committee
meetings held during 1997.
 
     The Board of Directors has a Compensation Committee (consisting of Messrs.
Penner and Thomas and Ms. Vitullo) and an Audit Committee (consisting of Dr.
Carter, Mr. Lowcock and Dr. McConnell). The Compensation Committee makes
recommendations to the Board concerning salaries and incentive compensation for
the Company's officers and employees and determines the compensation of the
President and Chief Executive Officer. The Audit Committee reviews the results
and scope of the audit and other accounting and related services and reviews and
evaluates the Company's internal control functions. The Board of Directors has
no nominating committee or any other committee performing a similar function.
 
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
 
     The Compensation Committee of the Board of Directors consists of directors
Messrs. Penner and Thomas and Ms. Vitullo. The Compensation Committee makes
recommendations to the Board of Directors concerning salaries and incentive
compensation for employees of and consultants to the Company, except that
                                        6
<PAGE>   9
 
the Compensation Committee has full power and authority to grant stock options
to the Company's executive officers under the Company's 1988 Stock Plan and 1996
Stock Plan. No director or executive officer of the Company has a relationship
that would constitute an interlocking relationship with executive officers or
directors of another entity. Mr. Thomas and Ms. Vitullo are affiliates of
Ventures and IBT, respectively, and were nominated to the Board of Directors
pursuant to an equity agreement described below under "Certain Relationships and
Related Transactions." Mr. Carter is an officer of Novo Nordisk and in the past
was nominated to the Board of Directors pursuant to the Novo Nordisk common
stock purchase agreement described below, although the Company is no longer
obligated to nominate Dr. Carter.
 
     Novo Nordisk A/S. In August 1993, the Company entered into a collaborative
agreement with Novo Nordisk with an initial three-year development term and Novo
Nordisk made an equity investment in the Company. In March 1996, the Company and
Novo Nordisk extended the term of the development program by an additional
two-year period through August 1998. On February 9, 1998, the Company announced
that it and Novo Nordisk had agreed to terminate the agreement between the two
parties. All rights will return to the Company and it will not have any future
obligation to Novo Nordisk. Novo Nordisk will reimburse the Company for the cost
of the ongoing Phase I clinical trial in Multiple Sclerosis. In February 1998,
Novo Nordisk paid the Company $1 million, the estimated costs to complete the
Phase I study. The Company recorded $2.6 million in contract revenues related to
this agreement in 1997 compared to $3.1 million and $3.0 million in 1996 and
1995, respectively.
 
EXECUTIVE OFFICERS
 
     The executive officers of the Company are listed below:
 
<TABLE>
<CAPTION>
                                                                                        OFFICER
        NAME AND NOMINEE           AGE                    POSITION(S)                    SINCE
        ----------------           ---                    -----------                   -------
<S>                                <C>   <C>                                            <C>
Barry M. Sherman, M.D.             56    President, Chief Executive Officer, Secretary   1996
                                         and Director
David V. Smith                     38    Vice President, Finance and Chief Financial     1997
                                         Officer
Maureen C. Howard, Ph.D.           45    Vice President, Research                        1997
Gilbert R. Mintz, Ph.D.            46    Vice President, Marketing and Business          1997
                                         Development
Carol A. Nacy, Ph.D                50    Chief Scientific Officer                        1997
Michael G. Shulman, M.D.           58    Vice President, Clinical Development            1997
Jeffrey L. Winkelhake              53    Vice President, Pharmaceutical Development      1993
</TABLE>
 
     Dr. Sherman's background is summarized under "Election of Directors" above.
 
     DAVID V. SMITH joined the Company in June 1997 as Vice President, Finance
and Chief Financial Officer. Prior to joining the Company, Mr. Smith served from
May 1988 to June 1997 at Genentech, Inc. in the United States and Europe, most
recently as Director of Accounting. Prior to joining Genentech, Mr. Smith held
planning and accounting positions at International Business Machines Corporation
and at Syntex Corporation.
 
     MAUREEN C. HOWARD, PH.D., joined the Company in September 1997 as Vice
President, Research. Prior to joining the Company, Dr. Howard served from
January 1986 to April 1997 as the Director of Immunology at DNAX Research
Institute of Molecular and Cellular Biology. Prior to that time, she was a
Fulbright and Fogarty fellow in the Laboratory of Immunology at the National
Institutes of Health.
 
     GILBERT R. MINTZ, PH.D., joined the Company in March 1997 as Vice
President, Marketing and Business Development. Prior to joining the Company, Dr.
Mintz served from November 1994 to January 1997 as Director of Marketing and
Business Development at Cygnus, Inc. Prior to joining Cygnus, Inc., he served
from February 1992 to November 1994 as Director of Licensing and Business
Development at Houghton Pharmaceuticals.
 
                                        7
<PAGE>   10
 
     CAROL A. NACY, PH.D., joined the Company in April 1997 as Chief Scientific
Officer. Prior to joining the Company, Dr. Nacy served from January 1993 to
November 1996 as Executive Vice President and Chief Scientific Officer at
Entremed, Inc. Prior to that time, she served for 17 years at Walter Reed Army
Institute of Research, most recently as Director of Infectious Diseases.
 
     MICHAEL G. SHULMAN, M.D., joined the Company in January 1997 as Vice
President, Clinical Development. Prior to joining the Company, Dr. Shulman
served from June 1995 as a Medical Director and consultant to SangStat Medical
Corporation. From February 1994 to December 1994, he served as Associate Medical
Director at Syntex Development Research, a pharmaceutical company. Prior to that
time, Dr. Shulman served for over two years as Associate Director of
Immunohematology and Cardiovascular for Sandoz Pharmaceuticals Corporation.
 
     JEFFREY L. WINKELHAKE, PH.D., joined the Company in April 1993 as Vice
President, Pharmaceutical Development. Prior to joining the Company, Dr.
Winkelhake served for three years as Director of Program Management at Cytel
Corporation, a biotechnology company. Prior to that, he served for over six
years as Director of Pharmacology at Cetus Corporation, also a biotechnology
company. Dr. Winkelhake received his Ph.D. in Immunochemistry/Pharmacology from
the University of Illinois in 1974.
 
     There are no family relationships among the executive officers of the
Company.
 
CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
 
     On March 10, 1995 the Company signed a Common Stock Purchase Agreement (the
"Agreement") with Ventures and IBT (collectively, the "Purchasers") to purchase
7,317,073 shares of Common Stock for approximately $15 million. The new shares
were priced at the average closing bid price for the Company's Common Stock over
a 30 day trading period. This transaction was approved by the Company's
shareholders and was completed on April 13, 1995. The Purchasers have the right
at any time after thirty (30) months from April 13, 1995 to request the Company
to effect a registration of at least 30% of the aggregate number of shares held
by the requesting Purchaser or any lesser percentage if the aggregate net
offering price would exceed $1,000,000. The Purchasers also have the right to
have their shares included in a registration by the Company of its securities
for its own account or the account of any of its shareholders. The Purchasers
have certain rights of representation on the Company's Board of Directors based
on certain minimum levels of ownership of the Company's Common Stock. Under the
Agreement, the Company is currently obligated to include in the slate of
nominees recommended by the Board of Directors and management at each election
of directors two candidates selected by Ventures, one candidate selected by IBT
and one candidate as mutually agreed to by IBT and Ventures. Upon the closing of
this transaction, the Board of Directors appointed to the Board to fill
vacancies two new members representing Ventures, Mr. Nicholas J. Lowcock and Mr.
James E. Thomas, and one new member representing IBT, Ms. Nicole Vitullo. These
three individuals have been nominated for re-election to the Board in connection
with the current election of directors.
 
                             EMPLOYEE BENEFIT PLANS
 
     The following is a brief summary of plans in effect during the fiscal year
ended December 31, 1997 under which officers, directors and employees of the
Company received benefits. The closing price of the Company's Common Stock
reported on the Nasdaq National Market on the Record Date was $1.344 per share.
 
401(K) PLAN
 
     In January of 1992 the Company adopted a tax-qualified employee savings and
retirement plan (the "401(k) Plan"), which generally covers all of the Company's
full-time employees who have attained age 21. Pursuant to the 401(k) Plan,
employees may elect to defer up to 15% of their current compensation (subject to
certain statutorily prescribed limits, including an annual limit of $9,500 in
1997). These deferred amounts are contributed to the 401(k) Plan. The 401(k)
Plan permits, but does not require, additional matching and Company
contributions on behalf of participants. Since the Plan's inception, the Company
has contributed an amount equal to 50% of each participant's contribution for up
to 2% of their eligible compensation. The
 
                                        8
<PAGE>   11
 
401(k) Plan is intended to qualify under Sections 401(k) and 401(a) of the
Internal Revenue Code of 1986, as amended (the "Code"). Contributions to such a
qualified plan are deductible to the Company when made and neither the
contributions nor the income earned on those contributions is taxable to
participants until withdrawn. All 401(k) Plan contributions are credited to
separate accounts maintained in trust by two individual trustees. Contributions
are invested, at the participant's direction, in one or more of the investment
funds available under the 401(k) Plan. All account balances are adjusted at
least annually to reflect the investment earnings and losses of the trust fund.
Each participant is fully vested in his or her salary deferral accounts under
the 401(k) Plan. Distributions may be made from a participant's account pursuant
to the 401(k) Plan's hardship withdrawal provisions as well as upon a
participant's termination of employment, disability or attainment of age 59 1/2.
Distributions will be in the form of a lump sum, installment payments or an
annuity, at the participant's discretion. Federal tax laws limit the amount that
may be added to a participant's accounts for any one year under a qualified plan
such as the 401(k) Plan to the lesser of (i) $30,000 or (ii) 25% of the
participant's compensation (net of salary deferral contributions) for the year.
 
1991 EMPLOYEE STOCK PURCHASE PLAN
 
     The Company's 1991 Employee Stock Purchase Plan (the "Purchase Plan") is
intended to qualify under Section 423 of the Code. The Purchase Plan was amended
by the Board in March 1996 to increase the number of shares available for
issuance thereunder. A total of 250,000 shares of Common Stock has been reserved
for issuance under the Purchase Plan. Under the Purchase Plan, the Company
withholds a specified percentage of each salary payment to participating
employees over certain offering periods. The Company is currently seeking
shareholder approval to amend the Purchase Plan to increase the number of shares
available for issuance under the Purchase Plan by 500,000 shares. See Proposal
No. 2 for a description of the Purchase Plan.
 
     As of December 31, 1997, a total of 209,359 shares of Common Stock have
been issued to employees at an aggregate purchase price of $648,008 and a
weighted average purchase price of $3.10 per share pursuant to offerings under
the Purchase Plan and 40,641 shares remained available for future issuance under
the Purchase Plan.
 
     The following table sets forth as to the executive officers named in the
table under "Executive Compensation" who purchased shares pursuant to the
Purchase Plan, all current executive officers as a group and all other employees
as a group (i) the number of shares of the Company's Common Stock purchased
under the Purchase Plan during the period from its inception until December 31,
1997, (ii) the aggregate purchase price thereof and (iii) the fair market value
as of December 31, 1997 of stock purchased through December 31, 1997 under the
Purchase Plan:
 
<TABLE>
<CAPTION>
                                                     NUMBER OF    AGGREGATE    FAIR VALUE
                                                      SHARES      PURCHASE      OF STOCK
      NAME OF INDIVIDUAL OR IDENTITY OF GROUP        PURCHASED      PRICE      PURCHASED
      ---------------------------------------        ---------    ---------    ----------
<S>                                                  <C>          <C>          <C>
Barry M. Sherman, M.D..............................     2,309     $  6,815      $  4,907
David V. Smith.....................................        --           --            --
John W. Varian.....................................    23,131       67,586        49,153
Gilbert R. Mintz, Ph.D.............................        --           --            --
Michael G. Shulman, M.D............................        --           --            --
Jeffrey L. Winkelhake, Ph.D........................     2,890        6,818         6,141
All current executive officers as a group (7
  persons).........................................     5,199       13,633        11,048
All employees as a group (including current
  officers who are not executive officers).........   182,851      546,140       388,559
</TABLE>
 
1997, options to purchase 1,059,295 shares were outstanding at a weighted
average exercise price of $3.78 per share and options to purchase 434,708 shares
had been exercised. A total of 305,997 shares remained available for the grant
of options.
 
     The 1988 Plan provides for the grant of "incentive stock options" within
the meaning of Section 422 of the Code and nonqualified stock options to
employees, directors and consultants of the Company. Incentive stock options may
be granted only to employees. The 1988 Plan is administered by the Board of
Directors,
 
                                        9
<PAGE>   12
 
which determines the terms of options granted, including the exercise price, the
number of shares subject to the option, and the option's exercisability. Options
granted to employees typically become exercisable at the rate of  1/8th of the
shares after six months and an additional 1/48th of the shares per month
thereafter.
 
     The 1988 Plan requires that the exercise price of incentive stock options
must be at least equal to the fair market value of such shares on the date of
grant and the exercise price of nonqualified stock options must be at least 85%
of the fair market value of such shares on the date of the grant. The maximum
term of options granted under the 1988 Plan is ten years. With respect to any
participant who owns stock possessing more than 10% of the voting rights of the
Company's outstanding capital stock, the exercise price of any option must be at
least equal to 110% of fair market value on the date of grant and the term may
be no longer than five years.
 
     Pursuant to the 1988 Plan, in the event of certain mergers of the Company
with other entities, transfers of voting control of the Company's capital stock
or sales of all or substantially all of the Company's assets, the Company will
request that the acquiring entity assume the Company's rights and obligations
under the 1988 Plan or provide similar options in substitution therefor. If the
acquiring entity chooses not to assume such rights and obligations or provide
substitute options, then the Company's Board of Directors will cause all
outstanding options (together with shares purchased upon exercise thereof) to
become fully vested prior to the event causing such acceleration and all
unexercised options will terminate upon completion of such event.
 
1996 STOCK PLAN
 
     A total of 1,000,000 shares of the Company's Common Stock has been reserved
for issuance under the Company's 1996 Stock Plan (the "1996 Plan"). At December
31, 1997, options to purchase 504,406 shares were outstanding at a weighted
average exercise price of $2.91 per share and no options had been exercised. A
total of 495,594 shares remained available for the grant of options. See
Proposal No. 3 regarding approval for an increase of 1,000,000 shares authorized
for issuance under and for a description of the 1996 Plan.
 
     Please see "Executive Compensation and Other Matters -- Executive
Compensation -- Option Grants in Fiscal 1997" for information with respect to
the grant of options to the executive officers during fiscal 1997. During the
fiscal year ended December 31, 1997, all current executive officers as a group
and all employees as a group were granted options to purchase 325,000 shares and
497,470 shares, respectively, at a weighted average exercise price of $3.01 per
share, pursuant to the 1988 and 1996 Plans.
 
1992 CONSULTANT STOCK PLAN
 
     A total of 50,000 shares of the Company's Common Stock has been reserved
for issuance under the Company's 1992 Consultant Stock Plan (the "Consultant
Plan") adopted by the Board of Directors in 1992. This plan allows the Company
to compensate consultants in Company stock rather than cash in certain
situations where the Company deems it desirable. At December 31, 1997, 26,347
shares had been issued under the Consultant Plan and 23,653 shares remained
available for issuance.
 
1995 DIRECTOR OPTION PLAN
 
     A total of 200,000 shares of the Company's Common Stock has been reserved
for issuance under the Company's 1995 Director Option Plan (the "Director
Plan"), adopted by the Board of Directors in 1995. The Director Plan expires by
its own terms in 2005. At December 31, 1997, options to purchase 30,000 shares
were outstanding at a weighted average exercise price of $3.77 per share, no
options had been exercised and 170,000 shares remained available for issuance.
 
     The Director Plan provides for the grant of "nonstatutory options" to
non-employee directors of the Company. The Director Plan is administered by the
Board of Directors. All grants of options under the Director Plan are automatic
and non-discretionary pursuant to the terms of the Director Plan. Each non-
employee director is automatically granted a nonstatutory option to purchase
25,000 shares of Common Stock on the date such person first becomes a director
(provided that non-employee directors who were directors on the effective date
of the Director Plan were granted a nonstatutory option to purchase 5,000 shares
in lieu of such grant). On the first day of each fiscal year thereafter, each
incumbent non-employee director will
 
                                       10
<PAGE>   13
 
automatically be granted a nonstatutory option to purchase 5,000 shares of
Common Stock (provided such person has served on the Board at least six months).
Options granted to directors typically become exercisable at the rate of 1/48th
of the shares per month after the date of grant. The Director Plan requires that
the exercise price of nonstatutory stock options is equal to the fair market
value of such shares on the date of grant. The term of options granted under the
Director Plan is ten years. In the event of certain mergers of the Company with
other entities, transfers of voting control of the Company's capital stock or
sales of all or substantially all of the Company's assets, all outstanding
options shall become fully vested.
 
     As of December 31, 1997, only Dr. Harden McConnell and Mr. Harry H. Penner,
Jr. had participated in the Director Plan.
 
                                       11
<PAGE>   14
 
                                 PROPOSAL NO. 2
 
                          APPROVAL OF AMENDMENT TO THE
                       1991 EMPLOYEE STOCK PURCHASE PLAN
 
     The 1991 Employee Stock Purchase Plan (the "Purchase Plan") was amended by
the Board of Directors in February 1998 to reserve an additional 500,000 shares
of Common Stock for issuance thereunder. A total of 250,000 shares are reserved
for issuance under the Purchase Plan, of which 209,359 shares had been issued as
of February 28, 1998, leaving 40,641 shares available for issuance. The
amendment will increase the number of shares available for issuance under the
Purchase Plan by an additional 500,000 shares. Since each executive officer of
the Company is eligible to purchase stock under the Purchase Plan, as amended,
each such officer has an interest in the proposed amendments to the Purchase
Plan.
 
     Approval of the addition of 500,000 shares to the pool reserved for
issuance under the Purchase Plan requires the affirmative vote of the holders of
a majority of the shares present in person or represented by proxy and entitled
to vote at the meeting.
 
     The Company believes that its Purchase Plan is an important factor in
attracting and retaining skilled personnel.
 
     The essential features of the Purchase Plan are outlined below.
 
GENERAL
 
     The Purchase Plan, and the right of participants to make purchases
thereunder, are intended to qualify under the provisions of Sections 421 and 423
of the Code. See "Tax Information -- The Purchase Plan."
 
PURPOSE
 
     The purpose of the Purchase Plan is to provide employees of the Company
with an opportunity to purchase Common Stock of the Company at a discount
through accumulated payroll deductions.
 
ADMINISTRATION
 
     The Purchase Plan is administered by the Board of Directors, who receive no
additional compensation for such service. All questions of interpretation or
application of the Purchase Plan are determined by the Board of Directors or its
appointed committee, whose decisions are final and binding upon all
participants. Members of the Board who are eligible employees are permitted to
participate in the Purchase Plan but may not vote on any matter affecting the
administration of the Purchase Plan or the grant of any option pursuant to the
Purchase Plan.
 
ELIGIBILITY
 
     Any person who has been employed by the Company for at least three
consecutive months is eligible to participate in the Purchase Plan, unless the
employee would own 5% or more of the total combined voting power or value of all
classes of stock of the Company or of its subsidiaries (including stock issuable
upon exercise of options held by such employee) at the end of the offering
period, or the employee would receive shares of Common Stock valued in excess of
$25,000 (computed as of the date of grant) pursuant to the Purchase Plan in any
calendar year. As of the Record Date, approximately 65 employees were eligible
to participate in the Purchase Plan.
 
OFFERING DATES
 
     The Purchase Plan is generally implemented by consecutive and overlapping
24-month offering periods. Offering periods commence on or about April 1 and
October 1 of each year.
 
                                       12
<PAGE>   15
 
ENROLLMENT IN THE PLAN
 
     Eligible employees become participants in the Purchase Plan by delivering
to the Company's payroll office a subscription agreement authorizing payroll
deductions. Under the Purchase Plan, once an employee elects to participate in
the Purchase Plan, enrollment in each successive offering period occurs
automatically unless the employee withdraws from participation in the Purchase
Plan.
 
PURCHASE PRICE
 
     The purchase price per share under the Purchase Plan is the lower of (i)
85% of the fair market value of a share of Common Stock on the date of
commencement of the offering (or, for employees beginning participation later,
the date such participation began) or (ii) 85% of the fair market value of a
share of Common Stock on the last day of the offering period. The fair market
value of the Common Stock on a given date is the closing sale price of the
Company's Common Stock, as reported on the Nasdaq National Market.
 
PAYMENT OF PURCHASE PRICE; PAYROLL DEDUCTIONS
 
     The purchase price of the shares is accumulated by after-tax payroll
deductions over the offering period. The deductions may not exceed 10% of a
participant's compensation. The total number of shares purchased by any
participant shall in no event exceed, in any calendar year, the number of shares
of Common Stock which $25,000 could purchase at the fair market value of a share
of the Company's Common Stock, calculated as of the offering date. A participant
may discontinue participation in the Purchase Plan, and may decrease or increase
the rate of payroll deductions during the offering period.
 
PURCHASE OF STOCK; EXERCISE OF OPTION
 
     By executing a subscription agreement to participate in the Purchase Plan,
the employee is entitled to have shares placed under option to him or her. The
maximum number of shares placed under option to a participant in an offering is
that number determined by dividing the total amount of the participant's
contribution for the offering period by the lower of (i) 85% of the fair market
value of the Common Stock at the beginning of the offering period (or the date
such employee's participation began) or (ii) 85% of the fair market value of the
Common Stock at the end of the offering period, but in no event shall more than
the number of shares of Common Stock which $25,000 could purchase at the fair
market value of a share of the Company's Common Stock, calculated as of the
offering date, be placed under option to a single participant in any one
calendar year. Unless the employee's participation is discontinued, the option
for the purchase of shares will be exercised automatically at the end of the
offering period at the applicable price. No fractional shares will be issued
upon exercise of the option. Any amounts insufficient to purchase a full share
remaining in a participant's account after exercise of the option will be
returned to the participant. No interest will accrue on the payroll deductions
of a participant in the Purchase Plan.
 
     The initial offering period under the Purchase Plan began on October 10,
1991, and as of February 28, 1998, 209,359 shares of the Company's Common Stock
have been sold under the Purchase Plan since the initial offering period began.
The number of shares sold in each offering period will vary with the number of
participants, the amount of their payroll deductions and the fair market value
of the Company's Common Stock.
 
WITHDRAWAL
 
     A participant's interest in a given offering may be terminated by signing
and delivering to the Company a notice of withdrawal from the Purchase Plan.
Upon withdrawal from the Purchase Plan, accrued but unused payroll deductions
are returned to the employee.
 
     Such withdrawal may be elected at any time prior to the end of the
applicable offering period. A participant's withdrawal from an offering will not
have any effect upon such participant's eligibility to participate in subsequent
offering periods under the Purchase Plan.
 
                                       13
<PAGE>   16
 
TERMINATION OF EMPLOYMENT
 
     Termination of a participant's employment for any reason, including
retirement or death, cancels participation in the Purchase Plan immediately. In
such event the payroll deductions credited to the participant's account will be
returned without interest to such participant, or, in the case of death, to the
person or persons entitled thereto as specified by the employee in the
subscription agreement.
 
CAPITAL CHANGES
 
     In the event of changes in the capitalization of the Company, such as stock
splits or stock dividends, which result in an increase or decrease in the number
of shares of Common Stock, without receipt of consideration by the Company,
appropriate adjustments will be made by the Company in the number of shares
subject to purchase and in the price per share.
 
EFFECT OF LIQUIDATION, DISSOLUTION, SALE OF ASSETS OR MERGER
 
     In the event of a liquidation or dissolution of the Company, an employee's
participation in the Purchase Plan will be terminated immediately before
consummation of such event unless otherwise provided by the Board. In the event
of a sale of all or substantially all of the assets of the Company or a merger
of the Company with or into another corporation, the employee's rights shall be
satisfied by assumption of the Company's obligations by such acquiring or
successor corporation. If such corporation refuses to assume those obligations,
the Board shall shorten the offering period then in progress and notify each
participant at least 10 days prior to the end of the shortened offering period
that the right to purchase shares will be automatically exercised, unless the
employee withdraws from the Purchase Plan prior thereto, at the end of such
shortened offering period.
 
NON-ASSIGNABILITY
 
     No rights or accumulated payroll deductions of an employee under the
Purchase Plan may be pledged, assigned or transferred for any reason, and any
such attempt may be treated by the Company as an election to withdraw from the
Purchase Plan.
 
REPORTS
 
     Individual accounting will be maintained for each participant in the
Purchase Plan. Each participant receives at least annually a report showing the
details of the participant's account.
 
AMENDMENT AND TERMINATION OF THE PLAN
 
     The Board may at any time amend, alter, suspend or discontinue the Purchase
Plan; however, except under certain conditions, no amendment, alteration,
suspension or discontinuation shall be made which would impair the rights of any
participant arising out of any offering period which has already commenced
without such participant's written consent. In addition, to the extent necessary
and desirable to comply with Section 423 of the Code (or any other applicable
law or regulation, including the requirements of the Nasdaq National Market or
an established stock exchange), the Company shall obtain shareholder approval of
any Purchase Plan amendment in such a manner and to such a degree as required.
 
TAX INFORMATION -- THE PURCHASE PLAN
 
     The Purchase Plan, and the right of participants to make purchases
thereunder, is intended to qualify under the provisions of Sections 421 and 423
of the Code. Under these provisions, no income will be taxable to a participant
until the shares purchased under the Purchase Plan are sold or otherwise
disposed of. Upon sale or other disposition of the shares, the participant will
generally be subject to tax and the amount of the tax will depend upon the
holding period. If the shares are sold or otherwise disposed of more than two
years from the first day of the offering period, the participant will recognize
ordinary income measured as the lesser of (a) the excess of the fair market
value of the shares at the time of such sale or disposition over the purchase
price, or
 
                                       14
<PAGE>   17
 
(b) an amount equal to 15% of the fair market value of the shares as of the
first day of the offering period. Any additional gain will be treated as
long-term capital gain. If the shares are sold or otherwise disposed of before
the expiration of this holding period, the participant will recognize ordinary
income generally measured as the excess of the fair market value of the shares
on the date the shares are purchased over the purchase price. Any additional
gain or loss on such sale or disposition will be long-term or short-term capital
gain or loss, depending on the holding period. The Company is not entitled to a
deduction for amounts taxed as ordinary income or capital gain to a participant
except to the extent of ordinary income recognized by participants upon a sale
or disposition of shares prior to the expiration of the holding period(s)
described above.
 
     The foregoing is only a summary of the effect of federal income taxation
upon the participant and the Company with respect to the shares purchased under
the Purchase Plan. Reference should be made to the applicable provisions of the
Code. In addition, the foregoing summary does not discuss the tax consequences
of a participant's death or the income tax laws of any state or foreign country
in which the participant may reside. Furthermore, future legislative,
administrative or judicial changes could affect the accuracy of the foregoing
summary.
 
VOTE REQUIRED
 
     At the Annual Meeting, the shareholders are being asked to approve the
amendment to the Purchase Plan to increase the number of shares issuable under
the Purchase Plan by 500,000 shares. The affirmative vote of holders of a
majority of the shares entitled to vote at the Annual Meeting at which a quorum
is present will be required to approve the amendment to the Purchase Plan.
 
     THE COMPANY'S BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" APPROVAL OF THE
AMENDMENT TO THE PURCHASE PLAN TO RESERVE AN ADDITIONAL 500,000 SHARES FOR
ISSUANCE THEREUNDER.
 
                                       15
<PAGE>   18
 
                                 PROPOSAL NO. 3
 
                  APPROVAL OF AMENDMENT TO THE 1996 STOCK PLAN
 
     At the Annual Meeting, the shareholders are being asked to approve an
amendment to the Company's 1996 Stock Plan (the "1996 Plan") to increase the
number of shares of the Company's Common Stock reserved for issuance under the
1996 Plan by 1,000,000 shares from a total of 1,000,000 shares which are
currently reserved for issuance thereunder. The 1996 Plan is described in more
detail below. Since each executive officer and director of the Company is
eligible to receive options under the 1996 Plan, as amended, each such officer
and director has an interest in the proposed amendments to the 1996 Plan.
 
     In October 1996, the Board of Directors adopted the 1996 Plan and reserved
1,000,000 shares of Common Stock for issuance thereunder. The 1996 Plan was
approved by the stockholders in May 1997. As of February 28, 1998, options to
purchase 517,470 shares had been granted pursuant to the 1996 Plan at a weighted
average exercise price of $2.91 per share and no options had been exercised. A
total of 482,530 shares are available for issuance pursuant to grant of options
under the 1996 Plan. The 1996 Plan is designed to retain, motivate and reward
employees and executives by providing them with long term equity participation
in the Company relating directly to the financial performance and long-term
growth of the Company.
 
SUMMARY OF THE 1996 PLAN
 
     General. The purpose of the 1996 Plan is to attract and retain the best
available personnel for positions of substantial responsibility with the
Company, to provide additional incentives to the employees, directors and
consultants of the Company and to promote the success of the Company's business.
Options granted under the 1996 Plan may be either "incentive stock options," as
defined in Section 422 of the Code, or nonstatutory stock options. Stock
purchase rights may also be granted pursuant to the 1996 Plan.
 
     Administration. The 1996 Plan may generally be administered by the Board or
a committee appointed by the Board (the "Administrator"). Subject to the other
provisions of the 1996 Plan, the Administrator has the power to determine the
terms and conditions of any options and stock purchase rights granted, including
but not limited to the exercise price, the number of shares subject to the
option or stock purchase right and the exercisability thereof. The 1996 Plan is
currently administered by the Compensation Committee of the Board of Directors.
 
     Eligibility; Limitations. Nonstatutory stock options and stock purchase
rights may be granted under the 1996 Plan to employees, directors and
consultants of the Company and any parent or subsidiary of the Company.
Incentive stock options may be granted only to employees. Any optionee who owns
more than 10% of the combined voting power of all classes of outstanding stock
of the Company is not eligible for the grant of an incentive stock option unless
the exercise price of the option is at least 110% of the fair market value of
the Common Stock on the date of grant.
 
     Section 162(m) of the Code places limits on the deductibility for federal
income tax purposes of compensation paid to certain executive officers of the
Company. In order to preserve the Company's ability to deduct the compensation
income associated with options granted to such persons, the 1996 Plan provides
that no employee may be granted, in any fiscal year of the Company, options to
purchase more than 500,000 shares of Common Stock. Notwithstanding this limit,
however, in connection with an employee's initial employment, he or she may be
granted options to purchase up to an additional 500,000 shares of Common Stock.
 
     Terms and Conditions of Options. Each option granted under the 1996 Plan is
evidenced by a written stock option agreement between the Company and the
optionee, and is subject to the following additional terms and conditions:
 
          (a) Exercise Price. The Administrator determines the exercise price of
     options at the time the options are granted. The exercise price of an
     incentive stock option may not be less than 100% of the fair market value
     of the Common Stock on the date such option is granted; provided, however,
     the exercise price of an incentive stock option granted to a 10%
     shareholder may not be less than 110% of the fair market value of the
     Common Stock on the date such option is granted. The fair market value of
     the
 
                                       16
<PAGE>   19
 
     Common Stock is generally determined with reference to the closing sale
     price for the Common Stock (or the closing bid if no sales were reported)
     on the last market trading day prior to the date the option is granted. The
     exercise price of a nonstatutory stock option may be determined by the
     Administrator; provided, however, the exercise price of a nonstatutory
     stock option intended to qualify as "performance-based compensation" within
     the meaning of Section 162(m) of the Code may not be less than 100% of the
     fair market value of the Common Stock on the date of grant.
 
          (b) Exercise of Option. The Administrator determines when options
     become exercisable, and may in its discretion, accelerate the vesting of
     any outstanding option. Stock options granted under the 1996 Plan generally
     vest and become exercisable over four years.
 
          (c) Form of Consideration. The means of payment for shares issued upon
     exercise of an option is specified in each option agreement. The 1996 Plan
     permits payment to be made by cash, check, promissory note, other shares of
     Common Stock of the Company (with some restrictions), cashless exercise, a
     reduction in the amount of any Company liability to the optionee, any other
     form of consideration permitted by applicable law, or any combination
     thereof.
 
          (d) Term of Option. The term of an incentive stock option may be no
     more than ten (10) years from the date of grant; provided that in the case
     of an incentive stock option granted to a 10% shareholder, the term of the
     option may be no more than five (5) years from the date of grant. No option
     may be exercised after the expiration of its term.
 
          (e) Termination of Employment. If an optionee's employment or
     consulting relationship terminates for any reason (other than death or
     disability), then all options held by the optionee under the 1996 Plan
     expire on the earlier of (i) the date set forth in his or her notice of
     grant or (ii) the expiration date of such option. To the extent the option
     is exercisable at the time of such termination, the optionee may exercise
     all or part of his or her option at any time before termination. In the
     absence of a specified time specified in the option agreement, the option
     must be exercised within three months following termination of employment
     or consulting relationship.
 
          (f) Permanent Disability. If an optionee's employment or consulting
     relationship terminates as a result of permanent and total disability (as
     defined in the Code), then all options held by such optionee under the 1996
     Plan will expire on the earlier of (i) twelve (12) months from the date of
     termination of the optionee's employment or (ii) the expiration date of the
     option. The optionee may exercise all or part of his or her option at any
     time before such expiration to the extent that such option was exercisable
     at the time of termination of employment.
 
          (g) Death. If an optionee dies while employed by the Company, his or
     her option will expire upon the earlier of (i) twelve (12) months after the
     optionee's death or (ii) the expiration date of the option. The executor or
     other legal representative of the optionee's estate may exercise all or
     part of the optionee's option at any time before such expiration to the
     extent that such option was exercisable at the time of optionee's death.
 
          (h) Nontransferability of Options. Unless determined otherwise by the
     Administrator, options granted under the 1996 Plan generally are not
     transferable other than by will or the laws of descent and distribution,
     and may be exercised during the optionee's lifetime only by the optionee.
     Following such transfer, any such options will continue to be subject to
     the same terms and conditions as were applicable immediately prior to the
     transfer.
 
          (i) Value Limitation. If the aggregate fair market value of all shares
     of Common Stock subject to an optionee's incentive stock option which are
     exercisable for the first time during any calendar year exceeds $100,000,
     the excess options will be treated as nonstatutory stock options.
 
          (j) Other Provisions. The stock option agreement may contain other
     terms, provisions and conditions not inconsistent with the 1996 Plan as may
     be determined by the Administrator.
 
     Terms and Conditions of Stock Purchase Rights. Each stock purchase right
granted under the 1996 Plan shall be evidenced by a written or electronic offer
which sets forth the terms, conditions and restrictions
                                       17
<PAGE>   20
 
related to the offer, including the number of shares that the offeree shall be
entitled to purchase, the price to be paid, and the time within which the
offeree must accept such offer. The offer shall be accepted by execution of a
restricted stock purchase agreement in such form as determined by the
Administrator. Unless the Administrator determines otherwise, the restricted
stock purchase agreement shall grant the Company a repurchase option exercisable
upon the voluntary or involuntary termination of the purchaser's service with
the Company for any reason (including death or disability). The purchase price
for shares repurchased pursuant to the restricted stock purchase agreement shall
be the original price paid by the purchaser and may be paid by cancellation of
any indebtedness of the purchaser to the Company. The Administrator shall
determine the rate at which the repurchase option lapses. Once the stock
purchase right is exercised, the purchaser shall have the rights equivalent to
those of a shareholder.
 
     Adjustment Upon Changes in Capitalization; Corporate Transactions. Subject
to any required action by the shareholders of the Company, the number of shares
of Common Stock covered by each outstanding option or stock purchase right, and
the number of shares of Common Stock which have been authorized for issuance
under the 1996 Plan but as to which no options or stock purchase rights have yet
been granted or which have been returned to the 1996 Plan upon cancellation or
expiration of an option or stock purchase right, as well as the price per share
of Common Stock covered by each such outstanding option or stock purchase right,
shall be proportionately adjusted for any increase or decrease in the number of
issued shares of Common Stock resulting from a stock split, reverse stock split,
stock dividend, combination or reclassification of the Common Stock, or any
other increase or decrease in the number of issued shares of Common Stock
effected without receipt of consideration by the Company. The conversion of any
convertible securities of the Company shall not be deemed to have been "effected
without receipt of consideration." Such adjustment shall be made by the Board,
whose determination in that respect shall be final, binding and conclusive.
Except as expressly provided herein, no issuance by the Company of shares of
stock of any class, or securities convertible into shares of stock of any class,
shall affect, and no adjustment by reason thereof shall be made with respect to,
the number or price of shares of Common Stock subject to an option or stock
purchase right.
 
     Dissolution or Liquidation. In the event of the proposed dissolution or
liquidation of the Company, the Administrator shall notify each optionee as soon
as practicable prior to the effective date of such proposed transaction. To the
extent it has not been previously exercised, the option or stock purchase right
shall terminate immediately prior to the consummation of such proposed action.
The Administrator in its discretion may provide for an optionee to have the
right to exercise his or her option until ten (10) days prior to such
transaction as to all of the optioned stock covered thereby, including shares as
to which the option would not otherwise be exercisable. In addition, the
Administrator may provide that any Company repurchase option applicable to any
shares purchased upon exercise of an option or stock purchase right shall lapse
as to all such shares, provided the proposed dissolution or liquidation takes
place at the time and in the manner contemplated. To the extent it has not been
previously exercised, an option or stock purchase right will terminate
immediately prior to the consummation of such proposed action.
 
     Merger or Asset Sale. In the event of a merger of the Company with or into
another corporation, or the sale of substantially all of the assets of the
Company, each outstanding option or stock purchase right will be assumed or an
equivalent option or right substituted by the successor corporation or a parent
or subsidiary of the successor corporation. In the event that the successor
corporation refuses to assume or substitute for the option or stock purchase
right, the optionee shall fully vest in and have the right to exercise the
option or stock purchase right as to all of the optioned stock, including shares
as to which it would not otherwise be vested or exercisable.
 
     Amendment and Termination of the 1996 Plan. The Board may amend, alter,
suspend or terminate the 1996 Plan, or any part thereof, at any time and for any
reason. However, the Company will obtain shareholder approval for any amendment
to the 1996 Plan to the extent necessary to comply with Section 162(m) and
Section 422 of the Code, or any similar rule or statute. No such action by the
Board or shareholders may alter or impair any option previously granted under
the 1996 Plan without the written consent of the optionee. Unless terminated
earlier, the 1996 Plan will terminate ten years from the date of its approval by
the shareholders or the Board, whichever is earlier.
 
                                       18
<PAGE>   21
 
FEDERAL INCOME TAX CONSEQUENCES
 
     Incentive Stock Options. An optionee who is granted an incentive stock
option does not recognize taxable income at the time the option is granted or
upon its exercise, although the exercise may subject the optionee to the
alternative minimum tax. Upon a disposition of the shares more than two years
after grant of the option and one year after exercise of the option, any gain or
loss is treated as long-term capital gain or loss. If these holding periods are
not satisfied, the optionee recognizes ordinary income at the time of
disposition equal to the difference between the exercise price and the lower of
(i) the fair market value of the shares at the date of the option exercise or
(ii) the sale price of the shares. Any gain or loss recognized on such a
premature disposition of the shares in excess of the amount treated as ordinary
income is treated as long-term or short-term capital gain or loss, depending on
the holding period. A different rule for measuring ordinary income upon such a
premature disposition may apply if the optionee is also an officer, director, or
10% shareholder of the Company. The Company is entitled to a deduction in the
same amount as the ordinary income recognized by the optionee.
 
     Nonstatutory Stock Options. An optionee does not recognize any taxable
income at the time he or she is granted a nonstatutory stock option. Upon
exercise, the optionee recognizes taxable income generally measured by the
excess of the then fair market value of the shares over the exercise price. Any
taxable income recognized in connection with an option exercise by an employee
of the Company is subject to tax withholding by the Company. The Company is
entitled to a deduction in the same amount as the ordinary income recognized by
the optionee. Upon a disposition of such shares by the optionee, any difference
between the sale price and the optionee's exercise price, to the extent not
recognized as taxable income as provided above, is treated as long-term or
short-term capital gain or loss, depending on the holding period.
 
     THE FOREGOING IS ONLY A SUMMARY OF THE EFFECT OF FEDERAL INCOME TAXATION
UPON OPTIONEES AND THE COMPANY WITH RESPECT TO THE GRANT AND EXERCISE OF OPTIONS
UNDER THE 1996 PLAN. IT DOES NOT PURPORT TO BE COMPLETE, AND DOES NOT DISCUSS
THE TAX CONSEQUENCES OF THE EMPLOYEE'S OR CONSULTANT'S DEATH OR THE PROVISIONS
OF THE INCOME TAX LAWS OF ANY MUNICIPALITY, STATE OR FOREIGN COUNTRY IN WHICH
THE EMPLOYEE OR CONSULTANT MAY RESIDE.
 
REQUIRED VOTE
 
     At the Annual Meeting, the shareholders are being asked to approve the
amendment to the 1996 Plan to increase the number of shares of Common Stock
reserved for issuance by 1,000,000 shares. The affirmative vote of the holders
of a majority of the shares entitled to vote at the Annual Meeting at which a
quorum is present will be required to approve the amendment to the 1996 Plan.
 
     THE BOARD OF DIRECTORS RECOMMENDS THAT SHAREHOLDERS VOTE "FOR" THE APPROVAL
OF THE AMENDMENT TO THE COMPANY'S 1996 PLAN TO RESERVE AN ADDITIONAL 1,000,000
SHARES FOR ISSUANCE THEREUNDER.
 
                                       19
<PAGE>   22
 
                                 PROPOSAL NO. 4
                          REINCORPORATION IN DELAWARE
 
INTRODUCTION
 
     The Board of Directors believes that the best interests of the Company and
its shareholders will be served by changing the state of incorporation of the
Company from California to Delaware (the "Reincorporation Proposal" or the
"Proposed Reincorporation"). As discussed below, the principal reasons for
reincorporation (the "Reincorporation") are the greater flexibility of Delaware
corporate law, the substantial body of case law interpreting that law and the
increased ability of the Company to attract and retain qualified directors. The
Company believes that its shareholders will benefit from the well-established
principles of corporate governance that Delaware law affords. Although Delaware
law provides the opportunity for the Board of Directors to adopt various
mechanisms which may enhance the Board's ability to negotiate favorable terms
for the shareholders in the event of an unsolicited takeover attempt, the
Reincorporation Proposal is not being proposed in order to prevent a current
unsolicited takeover attempt, nor is it in response to any present attempt known
to the Board of Directors to acquire control of the Company, obtain
representation on the Board of Directors or take significant action that affects
the Company. Shareholders are urged to read carefully the following sections of
this Proxy Statement, including the related exhibits, before voting on the
Reincorporation Proposal. Throughout the Proxy Statement, the term "Anergen
California" refers to the existing California corporation and the term "Anergen
Delaware" refers to the proposed new Delaware corporation, a wholly-owned
subsidiary of Anergen California, which is the proposed successor to Anergen
California.
 
     The Proposed Reincorporation will be effected by merging Anergen California
into Anergen Delaware (the "Merger"). Upon completion of the Merger, Anergen
California will cease to exist and Anergen Delaware will continue to operate the
business of the Company under the name Anergen, Inc. Pursuant to the Agreement
and Plan of Merger between Anergen California and Anergen Delaware, a copy of
which is attached hereto as Exhibit A (the "Merger Agreement"), each outstanding
share of Anergen California Common Stock, no par value per share, will
automatically be converted into one share of Delaware Common Stock, $0.001 par
value per share. IT IS NOT NECESSARY FOR SHAREHOLDERS TO EXCHANGE THEIR EXISTING
STOCK CERTIFICATES FOR STOCK CERTIFICATES OF ANERGEN DELAWARE. The Common Stock
of Anergen California is listed for trading on the Nasdaq National Market, and
after the merger Anergen Delaware's Common Stock will continue to be traded on
the Nasdaq National Market without interruption, under the same symbol ("ANRG")
as the shares of Anergen California Common Stock are traded under such system
prior to the merger.
 
     Upon the date on which the Merger is effective (the "Effective Date"),
Anergen Delaware will also assume and continue the outstanding stock options and
all other employee benefit plans of Anergen California. Each outstanding and
unexercised option, warrant or other right to purchase shares of Anergen
California Common Stock will become an option, warrant or right to purchase the
same number of shares of Anergen Delaware Common Stock on the same terms and
conditions and at the same exercise price applicable to any such Anergen
California option, warrant or stock purchase right at the Effective Date.
 
     The Reincorporation Proposal has been unanimously approved by Anergen
California's Board of Directors. If approved by the shareholders, it is
anticipated that the Effective Date of the Merger will be as soon as reasonably
practicable following the Annual Meeting of Shareholders. However, pursuant to
the Merger Agreement, the Merger may be abandoned or the Merger Agreement may be
amended by the Board of Directors (except that certain principal terms may not
be amended without shareholder approval) either before or after shareholder
approval has been obtained and prior to the Effective Date of the Proposed
Reincorporation if, in the opinion of the Board of Directors of either company,
circumstances arise that make it inadvisable to proceed.
 
     Shareholders of Anergen California will have no dissenters' rights of
appraisal with respect to the Reincorporation Proposal. See "Significant
Differences Between the Corporation Laws of California and Delaware--Appraisal
Rights." The discussion set forth below is qualified in its entirety by
reference to the
 
                                       20
<PAGE>   23
 
Merger Agreement, the Certificate of Incorporation and Bylaws of Anergen
Delaware, copies of which are attached hereto as Exhibits A, B and C,
respectively.
 
VOTE REQUIRED FOR THE REINCORPORATION PROPOSAL
 
     Approval of the Reincorporation Proposal, which will also constitute
approval of (i) the Merger Agreement and the Certificate of Incorporation and
Bylaws of Anergen Delaware, and (ii) the assumption of Anergen California's
employee benefit plans and outstanding stock options by Anergen Delaware, will
require the affirmative vote of the holders of a majority of the outstanding
shares of Anergen California Common Stock.
 
     THE BOARD OF DIRECTORS RECOMMENDS THAT SHAREHOLDERS VOTE "FOR" THE PROPOSED
REINCORPORATION IN DELAWARE.
 
PRINCIPAL REASONS FOR THE PROPOSED REINCORPORATION
 
     As the Company plans for the future, the Board of Directors and management
believe that it is essential to be able to draw upon well-established principles
of corporate governance in making legal and business decisions. The prominence
and predictability of Delaware corporate law provide a reliable foundation on
which the Company's governance decisions can be based and the Company believes
that shareholders will benefit from the responsiveness of Delaware corporate law
and Delaware courts to their needs and to those of the corporation they own.
 
     Prominence, Predictability and Flexibility of Delaware Law. For many years,
Delaware has followed a policy of encouraging incorporation in that state and,
in furtherance of that policy, has been a leader in adopting, construing and
implementing comprehensive, flexible corporate laws responsive to the legal and
business needs of corporations organized under its laws. Many corporations have
chosen Delaware initially as a state of incorporation or have subsequently
changed corporate domicile to Delaware in a manner similar to that proposed by
the Company. Because of Delaware's prominence as the state of incorporation for
many major corporations, both the legislature and courts in Delaware have
demonstrated an ability and a willingness to act quickly and effectively to meet
changing business needs. The Delaware courts have developed considerable
expertise in dealing with corporate issues and a substantial body of case law
has developed construing Delaware law and establishing public policies with
respect to corporate legal affairs.
 
     Well-Established Principles of Corporate Governance. There is substantial
judicial precedent in the Delaware courts as to the legal principles applicable
to measures that may be taken by a corporation and as to the conduct of the
Board of Directors under the business judgment rule. The Company believes that
its shareholders will benefit from the well-established principles of corporate
governance that Delaware law affords.
 
     Increased Ability to Attract and Retain Qualified Directors. Both
California and Delaware law permit a corporation to include a provision in its
certificate of incorporation which reduces or limits the monetary liability of
directors for breaches of fiduciary duty in certain circumstances. The
increasing frequency of claims and litigation directed against directors and
officers has greatly expanded the risks facing directors and officers of
corporations in exercising their respective duties. The amount of time and money
required to respond to such claims and to defend such litigation can be
substantial. It is the Company's desire to reduce these risks to its directors
and officers and to limit situations in which monetary damages can be recovered
against directors so that the Company may continue to attract and retain
qualified directors who otherwise might be unwilling to serve because of the
risks involved. The Company believes that, in general, Delaware law provides
greater protection to directors than California law and that Delaware case law
regarding a corporation's ability to limit director liability is more developed
and provides more guidance than California law.
 
NO CHANGE IN THE NAME, BOARD MEMBERS, BUSINESS, MANAGEMENT, EMPLOYEE BENEFIT
PLANS OR LOCATION OF PRINCIPAL EXECUTIVE OFFICES OR FACILITIES OF THE COMPANY
 
     The Proposed Reincorporation will effect a change in the legal domicile of
the Company, but not its physical location. The Proposed Reincorporation will
not result in any change in the name, business, management, fiscal year, assets
or liabilities (except to the extent of legal and other costs of effecting the
 
                                       21
<PAGE>   24
 
Proposed Reincorporation) or location of the principal facilities of the
Company. The seven directors who are elected at the 1998 Annual Meeting of
Shareholders will become the directors of Anergen Delaware. Anergen California's
employee benefit arrangements, including its stock option and stock purchase
plans, will be assumed and continued by Anergen Delaware upon the terms and
subject to the conditions currently in effect.
 
ANTITAKEOVER IMPLICATIONS
 
     Delaware, like many other states, permits a corporation to adopt a number
of measures through amendment of the certificate of incorporation or bylaws or
otherwise, which measures are designed to reduce a corporation's vulnerability
to unsolicited takeover attempts. The Reincorporation Proposal is not being
proposed in order to prevent an unsolicited takeover attempt, nor is it in
response to any present attempt known to the Board of Directors to acquire
control of the Company, obtain representation on the Board of Directors or take
significant action that affects the Company.
 
     In the discharge of its fiduciary obligations to its shareholders, the
Board of Directors has evaluated the Company's vulnerability to potential
unsolicited bidders. In the course of such evaluation, the Board of Directors of
the Company has considered or may consider in the future certain defensive
strategies designed to enhance the Board's ability to negotiate with an
unsolicited bidder. These strategies include, but are not limited to, the
issuance of authorized but unissued preferred stock, the rights and preferences
of which may be determined by the Board of Directors. Anergen California
currently has authorized but unissued Preferred Stock which may be issued by the
directors under California law and has been provided for by Anergen Delaware
under Delaware law.
 
     Certain effects of the Reincorporation Proposal may be considered to have
antitakeover implications. Section 203 of the Delaware General Corporation Law
("Section 203"), from which Anergen Delaware does not intend to opt out,
restricts certain "business combinations" with "interested stockholders" for
three years following the time that a person or entity becomes an interested
stockholder, unless the Board of Directors approves the business combination
and/or other requirements are met. See "Significant Differences Between the
Corporation Laws of California and Delaware -- Stockholder Approval of Certain
Business Combinations." The elimination of cumulative voting could be viewed as
having an antitakeover effect in that it can make it more difficult for a
minority stockholder to gain a seat on the Board. Other measures permitted under
Delaware law, which the Company does not intend to implement, include the
establishment of a staggered board of directors and the elimination of the right
of a 10% holder to call a special meeting of shareholders. The elimination of
cumulative voting and the establishment of a classified board of directors can
also be undertaken under California law in certain circumstances. Pursuant to
the Amended and Restated Articles of Incorporation of Anergen California,
however, the shareholders of Anergen California are not presently entitled to
cumulative voting in any election of directors. See "Cumulative Voting for
Directors." For a detailed discussion of all of the changes that will be
implemented as part of the Proposed Reincorporation, see Exhibits B and C and
"The Charters and Bylaws of Anergen California and Anergen Delaware." For a
discussion of differences between the laws of California and Delaware, see
"Significant Differences Between the Corporation Laws of California and
Delaware."
 
     The Board of Directors believes that unsolicited takeover attempts may be
unfair or disadvantageous to the Company and its shareholders because: (i) a
non-negotiated takeover bid may be timed to take advantage of temporarily
depressed stock prices; (ii) a non-negotiated takeover bid may be designed to
foreclose or minimize the possibility of more favorable competing bids or
alternative transactions; (iii) a non-negotiated takeover bid may involve the
acquisition of only a controlling interest in the corporation's stock, without
affording all shareholders the opportunity to receive the same economic
benefits; and (iv) certain of the Company's contractual arrangements provide
that they may not be assigned pursuant to a transaction which results in a
"change in control" of the Company without the prior written consent of the
licensor or other contracting party.
 
     By contrast, in a transaction in which an acquiror must negotiate with an
independent board of directors, the board can and should take account of the
underlying and long-term values of the Company's business, technology and other
assets, the possibilities for alternative transactions on more favorable terms,
possible
 
                                       22
<PAGE>   25
 
advantages from a tax-free reorganization, anticipated favorable developments in
the Company's business not yet reflected in the stock price and equality of
treatment of all shareholders.
 
     Despite the belief of the Board of Directors as to the benefits to
shareholders of the Reincorporation Proposal, it may be disadvantageous to the
extent that it has the effect of discouraging a future takeover attempt which is
not approved by the Board of Directors, but which a majority of the shareholders
might deem to be in their best interests or in which shareholders might receive
a premium for their shares over the then current market value or over their cost
basis in such shares. As a result of such effects of the Reincorporation
Proposal, shareholders who might wish to participate in a tender offer may not
have an opportunity to do so. In addition, to the extent that such provisions
enable the Board of Directors to resist a takeover or a change in control of the
Company, they could make it more difficult to change the existing Board of
Directors and management.
 
THE CHARTERS AND BYLAWS OF ANERGEN CALIFORNIA AND ANERGEN DELAWARE
 
     The provisions of the Anergen Delaware Certificate of Incorporation and
Bylaws are similar to those of Anergen California's Amended and Restated
Articles of Incorporation and Bylaws in many respects. However, the
Reincorporation Proposal includes the implementation of certain provisions in
the Anergen Delaware Certificate of Incorporation and Bylaws that alter the
rights of stockholders and the powers of management. The Company is also
separately seeking shareholder approval to increase the number of authorized
shares of the Company's Common Stock (see Proposal No. 7). In addition, Anergen
Delaware could implement certain other changes by amending its Certificate of
Incorporation and Bylaws in the future. For a discussion of such changes, see
"Significant Differences Between the Corporation Laws of California and
Delaware."
 
     The Amended and Restated Articles of Incorporation of Anergen California
currently authorize the Company to issue up to 40,000,000 shares of Common
Stock, no par value per share, and 10,000,000 shares of Preferred Stock, no par
value per share. The Certificate of Incorporation of Anergen Delaware provides
that the Company will have 60,000,000 authorized shares of Common Stock (if
Proposal No. 7 is approved), $.001 per share par value, and 10,000,000 shares of
Preferred Stock, $.001 per share par value. See Proposal No. 7 regarding an
increase in the authorized Common Stock to 60,000,000 shares. Like Anergen
California's Amended and Restated Articles of Incorporation, Anergen Delaware's
Certificate of Incorporation provides that the Board of Directors is entitled to
determine the powers, preferences and rights, and the qualifications,
limitations or restrictions, of the authorized and unissued preferred stock.
Although it has no present intention of doing so, the Board of Directors,
without stockholder approval, could authorize the issuance of additional
Preferred Stock upon terms which could have the effect of delaying or preventing
a change in control of the Company or modifying the rights of holders of the
Company's Common Stock under either California or Delaware law. The Board of
Directors could also utilize such shares for further financings, possible
acquisitions and other uses. The Amended and Restated Articles of Incorporation
of Anergen California also contain references to certain series of Preferred
Stock which previously had been outstanding prior to the Company's initial
public offering, but in connection therewith, all such series of Preferred Stock
automatically converted to Common Stock. Accordingly, the Certificate of
Incorporation of Anergen Delaware will not contain references to any series of
Preferred Stock since none is currently outstanding.
 
     Monetary Liability of Directors. The Amended and Restated Articles of
Incorporation of Anergen California and the Certificate of Incorporation of
Anergen Delaware both provide for the elimination of personal monetary liability
of directors to the fullest extent permissible under law. The provision
eliminating monetary liability of directors set forth in the Anergen Delaware
Certificate of Incorporation is potentially more expansive than the
corresponding provision in the Anergen California Amended and Restated Articles
of Incorporation, in that the former incorporates future amendments to Delaware
law with respect to the elimination of such liability. For a more detailed
explanation of the foregoing, see "Significant Differences Between the
Corporation Laws of California and Delaware -- Indemnification and Limitation of
Liability."
 
     Size of the Board of Directors. The Bylaws of Anergen Delaware provide for
a Board of Directors consisting of eight directors. The Bylaws of Anergen
California provide for a Board of Directors of seven to ten
 
                                       23
<PAGE>   26
 
members, with the exact number currently set at eight directors. Under
California law, although changes in the number of directors, in general, must be
approved by a majority of the outstanding shares, the Board of Directors may fix
the exact number of directors within a stated range set forth in the articles of
incorporation or bylaws, if the stated ranges have been approved by the
shareholders. Delaware law permits the board of directors acting alone, to
change the authorized number of directors by amendment to the bylaws, unless the
directors are not authorized to amend the bylaws or the number of directors is
fixed in the certificate of incorporation (in which case a change in the number
of directors may be made only by amendment to the certificate of incorporation
following approval of such change by the stockholders). The Anergen Delaware
Certificate of Incorporation provides that the number of directors will be as
specified in the Bylaws and authorizes the Board of Directors to adopt, alter,
amend or repeal the Bylaws. Following the Proposed Reincorporation, the Board of
Directors of Anergen Delaware could amend the Bylaws to change the size of the
Board of Directors from eight directors without further stockholder approval. If
the Reincorporation Proposal is approved, the seven directors of Anergen
California who are elected at the Annual Meeting of Shareholders in August 1998
will continue as the seven directors of Anergen Delaware after the Proposed
Reincorporation is consummated, with one vacancy on the Board.
 
     Cumulative Voting for Directors. Under California law, if a shareholder has
given notice of an intention to cumulate votes for the election of directors,
any other shareholder of the corporation is also entitled to cumulate his or her
votes at such election. Cumulative voting provides that each share of stock
normally having one vote is entitled to a number of votes equal to the number of
directors to be elected. A shareholder may then cast all such votes for a single
candidate or may allocate them among as many candidates as the shareholder may
choose. In the absence of cumulative voting, the holders of a majority of the
shares present or represented at a meeting in which directors are to be elected
would have the power to elect all the directors to be elected at such meeting,
and no person could be elected without the support of holders of a majority of
the shares present or represented at such meeting. Elimination of cumulative
voting could make it more difficult for a minority stockholder adverse to a
majority of the stockholders to obtain representation on the Company's Board of
Directors. California corporations may adopt provisions in their articles or
bylaws that eliminate cumulative voting effective when the Company's stock is
listed on a national stock exchange and when the Company's stock is held by 800
shareholders of record and included in the Nasdaq National Market System (a
"Listed Company"). The Company's articles contain such a provision, and, since
the Company qualifies as a Listed Company, it no longer allows cumulative
voting. Under Delaware law, cumulative voting in the election of directors is
not mandatory, but is a permitted option. The Anergen Delaware Certificate of
Incorporation does not provide for cumulative voting rights.
 
     Power to Call Special Shareholders' Meetings. Under California law, a
special meeting of shareholders may be called by the Board of Directors, the
Chairman of the Board, the President, the holders of shares entitled to cast not
less than ten percent (10%) of the votes at such meeting and such additional
persons as are authorized by the articles of incorporation or the bylaws. Under
Delaware law, a special meeting of stockholders may be called by the Board of
Directors or by any other person authorized to do so in the Certificate of
Incorporation or the Bylaws. The Bylaws of Anergen Delaware currently authorize
the Board of Directors, the Chairman of the Board, the President and the holders
of not less than ten percent (10%) of the shares entitled to vote to call a
special meeting of shareholders. Therefore, no substantive change is
contemplated in this provision, although the Board could in the future amend the
Company's Bylaws without stockholder approval.
 
     Filling Vacancies on the Board of Directors. Under California law, any
vacancy on the board of directors other than one created by removal of a
director may be filled by the Board. If the number of directors is less than a
quorum, a vacancy may be filled by the unanimous written consent of the
directors then in office, by the affirmative vote of a majority of the directors
at a meeting held pursuant to notice or waivers of notice or by a sole remaining
director. A vacancy created by removal of a director may be filled by the board
only if so authorized by a corporation's articles of incorporation or by a bylaw
approved by the corporation's shareholders. Anergen California's Amended and
Restated Articles of Incorporation and Bylaws permit directors to fill vacancies
created by removal of a director and also permit such vacancies to be filled by
the vote or written consent of the shareholders or by court order. Under
Delaware law, vacancies and newly
 
                                       24
<PAGE>   27
 
created directorships may be filled by a majority of the directors then in
office (even though less than a quorum) or by a sole remaining director, unless
otherwise provided in the certificate of incorporation or bylaws (or unless the
certificate of incorporation directs that a particular class of stock is to
elect such director(s), in which case a majority of the directors elected by
such class, or a sole remaining director so elected, shall fill such vacancy or
newly created directorship). The Bylaws of Anergen Delaware provide, that any
vacancy created by the removal of a director by the stockholders of Anergen
Delaware or by court order may be filled only by the stockholders. Following the
Proposed Reincorporation, the Board of Directors of Anergen Delaware could,
although it has no current intention to do so, amend the Bylaws to provide that
directors may fill any vacancy created by removal of directors by the
stockholders.
 
     Loans to Officers and Employees. Under California law, any loan or guaranty
to or for the benefit of a director or officer of the corporation or its parent
requires approval of the shareholders unless such loan or guaranty is provided
under a plan approved by shareholders owning a majority of the outstanding
shares of the corporation. However, under California law, shareholders of any
corporation with 100 or more shareholders of record, such as the Company, may
approve a bylaw authorizing the board of directors alone to approve loans or
guaranties to or on behalf of officers (whether or not such officers are
directors) if the board determines that any such loan or guaranty may reasonably
be expected to benefit the corporation. The Bylaws of Anergen California do not
contain the foregoing provision. Under Delaware law and the Anergen Delaware
Bylaws, Anergen Delaware may make loans to, guarantee the obligations of or
otherwise assist its officers or other employees and those of its subsidiaries
(including directors who are also officers or employees) when such action, in
the judgment of the directors, may reasonably be expected to benefit the
corporation. The Company has no present commitments, understandings or
intentions to make any loan or guarantee to any of its officers, directors or
employees.
 
     Voting by Ballot. California law provides that the election of directors
may proceed in the manner described in a corporation's bylaws. Anergen
California's Bylaws provide that the election of directors at a shareholders'
meeting may be by voice vote or ballot, unless prior to such vote a shareholder
at the meeting demands a vote by ballot, in which case such vote must be by
ballot. Under Delaware law, the right to vote by written ballot may be
restricted if so provided in the certificate of incorporation. The Bylaws of
Anergen Delaware do not address election by ballot, but the Certificate of
Incorporation of Anergen Delaware provides that election of directors need not
be by written ballot.
 
COMPLIANCE WITH DELAWARE AND CALIFORNIA LAW
 
     Following the Annual Meeting of Shareholders, if the Reincorporation
Proposal is approved, the Company will submit the Merger Agreement to the
offices of the California Secretary of State and the Delaware Secretary of State
for filing.
 
SIGNIFICANT DIFFERENCES BETWEEN THE CORPORATION LAWS OF CALIFORNIA AND DELAWARE
 
     The corporation laws of California and Delaware differ in many respects.
Although all the differences are not set forth in this Proxy Statement, certain
provisions, which could materially affect the rights of shareholders, are
discussed below.
 
     Stockholder Approval of Certain Business Combinations. In recent years, a
number of states have adopted special laws designed to make certain kinds of
"unfriendly" corporate takeovers, or other transactions involving a corporation
and one or more of its significant stockholders, more difficult. Under Section
203, certain "business combinations" of a Delaware corporation with "any
interested stockholder" are subject to a three-year moratorium unless specified
conditions are met.
 
     Section 203 prohibits a Delaware corporation from engaging in a "business
combination" with an "interested stockholder" for three years following the time
that such person or entity becomes an interested stockholder. With certain
exceptions, an interested stockholder is a person or entity who or which owns,
individually or with or through certain other persons or entities, fifteen
percent (15%) or more of the corporation's outstanding voting stock (including
any rights to acquire stock pursuant to an option, warrant, agreement,
arrangement or understanding, or upon the exercise of conversion or exchange
rights, and stock
                                       25
<PAGE>   28
 
with respect to which the person has voting rights only), or is an affiliate or
associate of the corporation and was the owner, individually or with or through
certain other persons or entities, of fifteen percent (15%) or more of such
voting stock at any time within the previous three years, or is an affiliate or
associate of any of the foregoing.
 
     For purposes of Section 203, the term "business combination" is defined
broadly to include mergers with or caused by the interested stockholder; sales
or other dispositions to the interested stockholder (except proportionately with
the corporation's other stockholders) of assets of the corporation or a direct
or indirect majority-owned subsidiary equal in aggregate market value to ten
percent (10%) or more of the aggregate market value of either the corporation's
consolidated assets or all of its outstanding stock; the issuance or transfer by
the corporation or a direct or indirect majority-owned subsidiary of stock of
the corporation or such subsidiary to the interested stockholder (except for
certain transfers in a conversion or exchange or a pro rata distribution or
certain other transactions, none of which increases the interested stockholder's
proportionate ownership of any class or series of the corporation's or such
subsidiary's stock or of the corporation's voting stock); any transaction
involving the corporation or any direct or indirect majority-owned subsidiary of
the corporation which has the effect, directly or indirectly, of increasing the
proportionate share of the stock of any class or series, or securities
convertible to such stock, of the corporation or the majority-owned subsidiary
which is owned by the interested stockholder (except as a result of immaterial
changes due to fractional share adjustments or as a result of purchases or
redemptions not caused, directly or indirectly, by the interested stockholder);
or receipt by the interested stockholder (except proportionately as a
stockholder), directly or indirectly, of any loans, advances, guarantees,
pledges or other financial benefits provided by or through the corporation or a
subsidiary.
 
     The three-year moratorium imposed on business combinations by Section 203
does not apply if: (i) prior to the time that such stockholder becomes an
interested stockholder, the board of directors approves either the business
combination or the transaction that resulted in the person or entity becoming an
interested stockholder; (ii) upon consummation of the transaction that made him
or her an interested stockholder, the interested stockholder owns at least
eighty-five percent (85%) of the corporation's voting stock outstanding at the
time the transaction commenced (excluding from the eighty-five percent (85%)
calculation shares owned by directors who are also officers of the target
corporation and shares held by employee stock plans that do not give employee
participants the right to decide confidentially whether to accept a tender or
exchange offer); or (iii) on or after the time such person or entity becomes an
interested stockholder, the board approves the business combination and it is
also approved at a stockholder meeting by sixty-six and two-thirds percent
(66 2/3%) of the outstanding voting stock not owned by the interested
stockholder.
 
     Section 203 only applies to certain publicly held corporations that have a
class of voting stock that is (i) listed on a national securities exchange, (ii)
authorized for quotation on the Nasdaq Stock Market or (iii) held of record by
more than 2,000 stockholders. Although a Delaware corporation to which Section
203 applies may elect not to be governed by Section 203, Anergen Delaware does
not intend to so elect.
 
     Section 203 will encourage any potential acquiror to negotiate with the
Company's Board of Directors. Section 203 also might have the effect of limiting
the ability of a potential acquiror to make a two-tiered bid for Anergen
Delaware in which all stockholders would not be treated equally. Shareholders
should note, however, that the application of Section 203 to Anergen Delaware
will confer upon the Board the power to reject a proposed business combination
in certain circumstances, even though a potential acquiror may be offering a
substantial premium for Anergen Delaware's shares over the then-current market
price. Section 203 would also discourage certain potential acquirors unwilling
to comply with its provisions. See "Shareholder Voting" herein.
 
     Removal of Directors. Under California law, any director or the entire
board of directors may be removed, with or without cause, with the approval of a
majority of the outstanding shares entitled to vote; however, no individual
director may be removed (unless the entire board is removed) if the number of
votes cast against such removal would be sufficient to elect the director under
cumulative voting. Under Delaware law, a director of a corporation that does not
have a classified board of directors or cumulative voting may be removed with or
without cause with the approval of a majority of the outstanding shares entitled
to vote at an
 
                                       26
<PAGE>   29
 
election of directors. In the case of a Delaware corporation having cumulative
voting, if less than the entire board is to be removed, a director may not be
removed without cause if the number of shares voted against such removal would
be sufficient to elect the director under cumulative voting. A director of a
corporation with a classified board of directors may be removed only for cause,
unless the certificate of incorporation otherwise provides. The Certificate of
Incorporation of Anergen Delaware does not provide for a classified board of
directors or for cumulative voting.
 
     Classified Board of Directors. A classified board is one on which a certain
number, but not all, of the directors are elected on a rotating basis each year.
This method of electing directors makes changes in the composition of the board
of directors more difficult, and thus a potential change in control of a
corporation a lengthier and more difficult process. California law permits
certain qualifying corporations to provide for a classified board of directors
by adopting amendments to their articles of incorporation or bylaws, which
amendments must be approved by the shareholders. Although Anergen California
qualifies to adopt a classified board of directors, its Board of Directors has
no present intention of doing so. Delaware law permits, but does not require, a
classified board of directors, pursuant to which the directors can be divided
into as many as three classes with staggered terms of office, with only one
class of directors standing for election each year. The Anergen Delaware
Certificate of Incorporation and Bylaws do not provide for a classified board,
and Anergen Delaware presently does not intend to propose establishment of a
classified board. The establishment of a classified board following the Proposed
Reincorporation would require the approval of the stockholders of Anergen
Delaware.
 
     Indemnification and Limitation of Liability. California and Delaware have
similar laws respecting indemnification by a corporation of its officers,
directors, employees and other agents. The laws of both states also permit, with
certain exceptions, a corporation to adopt a provision in its articles of
incorporation or certificate of incorporation, as the case may be, eliminating
the liability of a director to the corporation or its shareholders for monetary
damages for breach of the director's fiduciary duty. There are nonetheless
certain differences between the laws of the two states respecting
indemnification and limitation of liability.
 
     The Amended and Restated Articles of Incorporation of Anergen California
eliminate the liability of directors to the corporation to the fullest extent
permissible under California law. California law does not permit the elimination
of monetary liability where such liability is based on: (a) intentional
misconduct or knowing and culpable violation of law; (b) acts or omissions that
a director believes to be contrary to the best interests of the corporation or
its shareholders, or that involve the absence of good faith on the part of the
director; (c) receipt of an improper personal benefit; (d) acts or omissions
that show reckless disregard for the director's duty to the corporation or its
shareholders, where the director in the ordinary course of performing a
director's duties should be aware of a risk of serious injury to the corporation
or its shareholders; (e) acts or omissions that constitute an unexcused pattern
of inattention that amounts to an abdication of the director's duties to the
corporation or its shareholders; (f) interested transactions between the
corporation and a director in which a director has a material financial
interest; and (g) liability for improper distributions, loans or guarantees.
 
     The Certificate of Incorporation of Anergen Delaware also eliminates the
liability of directors to the corporation or its stockholders for monetary
damages for breach of fiduciary duty as a director to the fullest extent
permissible under Delaware law, as such law exists currently or as it may be
amended in the future. Under Delaware law, such provision may not eliminate or
limit director monetary liability for: (a) breaches of the director's duty of
loyalty to the corporation or its stockholders; (b) acts or omissions not in
good faith or involving intentional misconduct or knowing violations of law; (c)
the payment of unlawful dividends or unlawful stock repurchases or redemptions;
or (d) transactions in which the director received an improper personal benefit.
Such limitation of liability provisions also may not limit a director's
liability for violation of, or otherwise relieve Anergen Delaware or its
directors from the necessity of complying with, federal or state securities
laws, or affect the availability of non-monetary remedies such as injunctive
relief or rescission.
 
     California law permits indemnification of expenses incurred in derivative
or third-party actions, except that with respect to derivative actions (a) no
indemnification may be made when a person is adjudged liable to the corporation
in the performance of that person's duty to the corporation and its shareholders
unless a court
 
                                       27
<PAGE>   30
 
determines such person is entitled to indemnity for expenses, and then such
indemnification may be made only to the extent that such court shall determine;
and (b) no indemnification may be made without court approval in respect of
amounts paid or expenses incurred in settling or otherwise disposing of a
threatened or pending action or amounts incurred in defending a pending action
that is settled or otherwise disposed of without court approval.
 
     California law requires indemnification when the individual has defended
successfully the action on the merits (as opposed to Delaware law, which
requires indemnification relating to a successful defense on the merits or
otherwise).
 
     Delaware law generally permits indemnification of expenses, including
attorneys fees, actually and reasonably incurred in the defense or settlement of
a derivative or third-party action, provided there is a determination by a
majority vote of the disinterested directors, even though such directors may
constitute less than a quorum; if there are no such directors, or if such
directors so direct, by independent legal counsel in a written opinion; or by
the stockholders, that the person seeking indemnification acted in good faith
and in a manner reasonably believed to be in or (in contrast to California law)
not opposed to the best interests of the corporation. Without court approval,
however, no indemnification may be made in respect of any derivative action in
which such person is adjudged liable for negligence or misconduct in the
performance of his or her duty to the corporation. Delaware law requires
indemnification of expenses when the individual being indemnified has
successfully defended any action, claim, issue, or matter therein, on the merits
or otherwise.
 
     Expenses incurred by an officer or director in defending an action may be
paid in advance, under Delaware law and California law, if such director or
officer undertakes to repay such amounts if it is ultimately determined that he
or she is not entitled to indemnification. In addition, the laws of both states
authorize a corporation's purchase of indemnity insurance for the benefit of its
officers, directors, employees and agents whether or not the corporation would
have the power to indemnify against the liability covered by the policy.
 
     California law permits a California corporation to provide rights to
indemnification beyond those provided therein to the extent such additional
indemnification is authorized in the corporation's articles of incorporation.
Thus, if so authorized, rights to indemnification may be provided pursuant to
agreements or bylaw provisions which make mandatory the permissive
indemnification provided by California law. Under California law, there are two
limitations on such additional rights to indemnification: (i) such
indemnification is not permitted for acts, omissions or transactions from which
a director of a California corporation may not be relieved of personal
liability, as described above; and (ii) such indemnification is not permitted in
circumstances where California law expressly prohibits indemnification, as
described above. Anergen California's Amended and Restated Articles of
Incorporation permit indemnification of its directors and officers to the extent
permitted by the California Corporations Code. Anergen California has entered
into indemnification agreements with its officers and directors.
 
     Delaware law also permits a Delaware corporation to provide indemnification
in excess of that provided by statute. In contrast to California law, Delaware
law does not require authorizing provisions in the certificate of incorporation
and does not contain express prohibitions on indemnification in certain
circumstances; limitations on indemnification may be imposed by a court,
however, based on principles of public policy.
 
     After the Proposed Reincorporation, the Company proposes to adopt the
Indemnification Agreement described in "PROPOSAL NO. 5 -- APPROVAL OF FORM OF
INDEMNIFICATION AGREEMENT."
 
     Inspection of Shareholder List. Both California and Delaware law allow any
shareholder to inspect the shareholder list for a purpose reasonably related to
such person's interest as a shareholder. California law provides, in addition,
for an absolute right to inspect and copy the corporation's shareholder list by
persons holding an aggregate of five percent (5%) or more of a corporation's
voting shares, or shareholders holding an aggregate of one percent (1%) or more
of such shares who have filed a Schedule 14A with the Securities and Exchange
Commission in connection with a contested election of directors. Under
California law, such absolute inspection rights also apply to a corporation
formed under the laws of any other state if its principal executive offices are
in California or if it customarily holds meetings of its board in California.
Delaware law
 
                                       28
<PAGE>   31
 
contains no provisions comparable to the absolute right of inspection provided
by California law to certain shareholders.
 
  Dividends and Repurchases of Shares. California law dispenses with the
concepts of par value of shares as well as statutory definitions of capital,
surplus and the like. The concepts of par value, capital and surplus are
retained under Delaware law.
 
     Under California law, a corporation may not make any distribution
(including dividends, whether in cash or other property, and repurchases of its
shares, other than repurchases of its shares issued under employee stock plans
contemplated by Section 408 of the California Corporations Code) unless either
(i) the corporation's retained earnings immediately prior to the proposed
distribution equal or exceed the amount of the proposed distribution or (ii)
immediately after giving effect to such distribution, the corporation's assets
(exclusive of goodwill, capitalized research and development expenses and
deferred charges) would be at least equal to 1 1/4 times its liabilities (not
including deferred taxes, deferred income and other deferred credits), and the
corporation's current assets would be at least equal to its current liabilities
(or 1 1/4 times its current liabilities if the average pre-tax and pre-interest
expense earnings for the preceding two fiscal years were less than the average
interest expense for such years). Such tests are applied to California
corporations on a consolidated basis.
 
     Delaware law permits a corporation to declare and pay dividends out of
surplus or, if there is no surplus, out of net profits for the fiscal year in
which the dividend is declared and/or for the preceding fiscal year as long as
the amount of capital of the corporation following the declaration and payment
of the dividend is not less than the aggregate amount of the capital represented
by the issued and outstanding stock of all classes having a preference upon the
distribution of assets. In addition, Delaware law generally provides that a
corporation may redeem or repurchase its shares only if the capital of the
corporation is not impaired immediately prior thereto and such redemption or
repurchase would not impair the capital of the corporation.
 
     To date, the Company has never declared or paid any cash dividends on its
Common Stock and does not anticipate doing so for the foreseeable future.
 
  Stockholder Voting. Both California and Delaware law generally require that
the holders of a majority of the outstanding shares of both acquiring and target
corporations approve statutory mergers. Delaware law does not require a
stockholder vote of the surviving corporation in a merger (unless the
corporation provides otherwise in its certificate of incorporation) if (a) the
merger agreement does not amend the existing certificate of incorporation, (b)
each share of the stock of the surviving corporation outstanding immediately
before the effective date of the merger is an identical outstanding or treasury
share after the merger, and (c) either no shares of common stock of the
surviving corporation and no shares, securities or obligations convertible into
such stock are to be issued or delivered under the plan of merger, or the
authorized unissued shares or the treasury shares of common stock of the
surviving corporation to be issued or delivered under the plan of merger plus
those initially issuable upon conversion of any other shares, securities or
obligations to be issued or delivered under such plan do not exceed twenty
percent (20%) of the shares of common stock of such constituent corporation
outstanding immediately prior to the effective date of the merger. California
law contains a similar exception to its voting requirements for reorganizations
where shareholders or the corporation itself, or both, immediately prior to the
reorganization will own, immediately after the reorganization, equity securities
constituting more than five-sixths of the voting power of the surviving or
acquiring corporation or its parent entity.
 
     Both California law and Delaware law also require that a sale of all or
substantially all of the assets of a corporation be approved by a majority of
the outstanding voting shares of the corporation transferring such assets.
 
     With certain exceptions, California law also requires that mergers,
reorganizations, certain sales of assets and similar transactions be approved by
a majority vote of each class of shares outstanding. In contrast, Delaware law
generally does not require class voting, except in certain transactions
involving an amendment to the certificate of incorporation that adversely
affects a specific class of shares. As a result, stockholder approval
 
                                       29
<PAGE>   32
 
of such transactions may be easier to obtain under Delaware law for companies
which have more than one class of shares outstanding.
 
     California law also requires that holders of nonredeemable common stock
receive nonredeemable common stock in a merger of the corporation with the
holder of more than fifty percent (50%) but less than ninety percent (90%) of
such common stock or its affiliate unless all of the holders of such common
stock consent to the transaction. This provision of California law may have the
effect of making a "cash-out" merger by a majority shareholder more difficult to
accomplish. Although Delaware law does not parallel California law in this
respect, under some circumstances Section 203 does provide similar protection
against coercive two-tiered bids for a corporation in which the stockholders are
not treated equally. See "Significant Differences Between the Corporation Laws
of California and Delaware -- Stockholder Approval of Certain Business
Combinations."
 
     California law provides that, except in certain circumstances, when a
tender offer or a proposal for a reorganization or for a sale of assets is made
by an interested party (generally a controlling or managing person of the target
corporation), an affirmative opinion in writing as to the fairness of the
consideration to be paid to the shareholders must be delivered to shareholders.
This fairness opinion requirement does not apply to a corporation that does not
have shares held of record by at least 100 persons, or to a transaction that has
been qualified under California state securities laws. Furthermore, if a tender
of shares or vote is sought pursuant to an interested party's proposal and a
later proposal is made by another party at least ten days prior to the date of
acceptance of the interested party proposal, the shareholders must be informed
of the later offer and be afforded a reasonable opportunity to withdraw any
vote, consent or proxy, or to withdraw any tendered shares. Delaware law has no
comparable provision.
 
     Interested Director Transactions. Under both California and Delaware law,
certain contracts or transactions in which one or more of a corporation's
directors has an interest are not void or voidable because of such interest,
provided that certain conditions, such as obtaining the required approval and
fulfilling the requirements of good faith and full disclosure, are met. With
certain exceptions, the conditions are similar under California and Delaware
law. Under California and Delaware law, (a) either the shareholders or the board
of directors must approve any such contract or transaction after full disclosure
of the material facts without counting the vote of the interested director or
directors and, in the case of board approval, the contract or transaction must
also be "just and reasonable" (in California) or "fair" (in Delaware) to the
corporation, or (b) the contract or transaction must have been just and
reasonable or fair as to the corporation at the time it was approved. In the
latter case, California law explicitly places the burden of proof on the
interested director. Under California law, if shareholder approval is sought,
the interested director is not entitled to vote his shares at a shareholder
meeting with respect to any action regarding such contract or transaction. If
board approval is sought, the contract or transaction must be approved by a
majority vote of a quorum of the directors, without counting the vote of any
interested directors (except that interested directors may be counted for
purposes of establishing a quorum). Under Delaware law, if board approval is
sought, the contract or transaction must be approved by a majority of the
disinterested directors (even if the disinterested directors are less than a
quorum). Though Anergen Delaware, like Anergen California, has a board
constituted of one (1) inside director and six (6) outside directors,
conceivably certain transactions that the Board of Directors of Anergen
California might not be able to approve because of the number of interested
directors could be approved by a majority of the disinterested directors of
Anergen Delaware, although less than a majority of a quorum. The Company is not
aware of any plans to propose any transaction involving directors of the Company
that could not be so approved under California law but could be so approved
under Delaware law.
 
     Shareholder Derivative Suits. California law provides that a shareholder
bringing a derivative action on behalf of a corporation need not have been a
shareholder at the time of the transaction in question, provided that certain
tests are met. Under Delaware law, a stockholder may bring a derivative action
on behalf of the corporation only if the stockholder was a stockholder of the
corporation at the time of the transaction in question or if his or her stock
thereafter devolved upon him or her by operation of law. California law also
provides that the corporation or the defendant in a derivative suit may make a
motion to the court for an order requiring the plaintiff shareholder to furnish
a security bond. Delaware does not have a similar bonding requirement.
                                       30
<PAGE>   33
 
     Appraisal Rights. Under both California and Delaware law, a shareholder of
a corporation participating in certain major corporate transactions may, under
varying circumstances, be entitled to appraisal rights pursuant to which such
shareholder may receive cash in the amount of the fair market value of his or
her shares in lieu of the consideration he or she would otherwise receive in the
transaction. Under Delaware law, such fair market value is determined exclusive
of any element of value arising from the accomplishment or expectation of the
merger or consolidation, and such appraisal rights are not available (a) with
respect to the sale, lease or exchange of all or substantially all of the assets
of a corporation, (b) with respect to a merger or consolidation by a corporation
the shares of which are either listed on a national securities exchange or are
held of record by more than 2,000 holders if such stockholders receive only
shares of the surviving corporation or shares of any other corporation that are
either listed on a national securities exchange or held of record by more than
2,000 holders, plus cash in lieu of fractional shares of such corporations, or
(c) to stockholders of a corporation surviving a merger if no vote of the
stockholders of the surviving corporation is required to approve the merger
under certain provisions of Delaware law.
 
     The limitations on the availability of appraisal rights under California
law are different from those under Delaware law. Shareholders of a California
corporation whose shares are listed on a national securities exchange or on a
list of over-the-counter margin stocks issued by the Board of Governors of the
Federal Reserve System generally do not have such appraisal rights unless the
holders of at least five percent (5%) of the class of outstanding shares claim
the right or the corporation or any law restricts the transfer of such shares.
Appraisal rights are also unavailable if the shareholders of a corporation or
the corporation itself, or both, immediately prior to the reorganization, will
own immediately after the reorganization equity securities constituting more
than five-sixths of the voting power of the surviving or acquiring corporation
or its parent entity (as will be the case in the Reincorporation Proposal).
California law generally affords appraisal rights mainly in sale of asset
reorganizations. Appraisal or dissenters' rights are, therefore, not available
to shareholders of Anergen California with respect to the Reincorporation
Proposal.
 
     Dissolution. Under California law, shareholders holding fifty percent (50%)
or more of the total voting power may authorize a corporation's dissolution,
with or without the approval of the corporation's board of directors, and this
right may not be modified by the articles of incorporation. Under Delaware law,
unless the board of directors approves the proposal to dissolve, the dissolution
must be approved by all the stockholders entitled to vote thereon. Only if the
dissolution is initially approved by the board of directors may it be approved
by a simple majority of the outstanding shares of the corporation's stock
entitled to vote.
 
CERTAIN FEDERAL INCOME TAX CONSIDERATIONS
 
     The following is a discussion of certain federal income tax considerations
that may be relevant to holders of Anergen California Common Stock who receive
Anergen Delaware Common Stock in exchange for their Anergen California Common
Stock as a result of the Proposed Reincorporation. The discussion does not
address all of the tax consequences of the Proposed Reincorporation that may be
relevant to particular Anergen California shareholders, such as dealers in
securities, or those Anergen California shareholders who acquired their shares
upon the exercise of stock options, nor does it address the tax consequences to
holders of options or warrants to acquire Anergen California Common Stock.
Furthermore, no foreign, state, or local tax considerations are addressed
herein. IN VIEW OF THE VARYING NATURE OF SUCH TAX CONSEQUENCES, EACH SHAREHOLDER
IS URGED TO CONSULT HIS OR HER OWN TAX ADVISOR AS TO THE SPECIFIC TAX
CONSEQUENCES OF THE PROPOSED REINCORPORATION, INCLUDING THE APPLICABILITY OF
FEDERAL, STATE, LOCAL OR FOREIGN TAX LAWS.
 
     Subject to the limitations, qualifications and exceptions described herein,
and assuming the Proposed Reincorporation qualifies as a reorganization within
the meaning of Section 368(a) of the Code, the following tax consequences
generally should result:
 
          (a) No gain or loss should be recognized by holders of Anergen
     California Common Stock upon receipt of Anergen Delaware Common Stock
     pursuant to the Proposed Reincorporation;
 
                                       31
<PAGE>   34
 
          (b) The aggregate tax basis of the Anergen Delaware Common Stock
     received by each shareholder in the Proposed Reincorporation should be
     equal to the aggregate tax basis of the Anergen California Common Stock
     surrendered in exchange therefor; and
 
          (c) The holding period of the Anergen Delaware Common Stock received
     by each shareholder of Anergen California should include the period for
     which such shareholder held the Anergen California Common Stock surrendered
     in exchange therefor, provided that such Anergen California Common Stock
     was held by the shareholder as a capital asset at the time of the Proposed
     Reincorporation.
 
          (d) The Company should not recognize gain or loss for federal income
     tax purposes as a result of the Proposed Reincorporation and Anergen
     Delaware should succeed, without adjustment, to the federal income tax
     attributes of Anergen California.
 
     The Company has not requested a ruling from the Internal Revenue Service
(the "IRS") or an opinion of counsel with respect to the federal income tax
consequences of the Proposed Reincorporation under the Code.
 
     A successful IRS challenge to the reorganization status of the Proposed
Reincorporation (in consequence of a failure to satisfy the "continuity of
interest" requirement or otherwise) would result in a shareholder recognizing
gain or loss with respect to each share of Anergen California Common Stock
exchanged in the Proposed Reincorporation equal to the difference between the
shareholder's basis in such share and the fair market value, as of the time of
the Proposed Reincorporation, of the Anergen Delaware Common Stock received in
exchange therefor. In such event, a shareholder's aggregate basis in the shares
of Anergen Delaware Common Stock received in the exchange would equal their fair
market value on such date, and the shareholder's holding period for such shares
would not include the period during which the shareholder held Anergen
California Common stock. Even if the Proposed Reincorporation qualifies as a
reorganization under the Code, a shareholder would recognize gain to the extent
the shareholder received (actually or constructively) consideration other than
Anergen Delaware Common Stock in exchange for the shareholder's Anergen
California Common Stock.
 
                                       32
<PAGE>   35
 
                                 PROPOSAL NO. 5
 
                 APPROVAL OF FORM OF INDEMNIFICATION AGREEMENT
 
GENERAL
 
     The Company currently holds agreements with its directors and officers that
eliminate the liability of directors and officers to the fullest extent
permissible under California law. In the event that the Company's Proposed
Reincorporation in Delaware (see "PROPOSAL NO. 4 -- REINCORPORATION IN
DELAWARE") receives the requisite votes for shareholder approval and that the
merger described therein is effected, the Company proposes to enter into new
indemnification agreements in substantially the form attached hereto as Exhibit
D (the "Indemnification Agreements") to provide for the maximum indemnification
allowed under applicable Delaware law and under Anergen Delaware's Certificate
of Incorporation. Although California and Delaware indemnification laws are
similar, Delaware law provides a somewhat broader scope of protection for
directors and officers. (See "PROPOSAL NO. 4 -- REINCORPORATION IN
DELAWARE -- Significant Differences between the Corporation Law of California
and Delaware" for a fuller explanation of the material differences between
Delaware and California law.)
 
     The Board of Directors believes that the Indemnification Agreements serve
the best interests of the Company and its stockholders by strengthening the
Company's ability to attract and retain over time the services of knowledgeable
and experienced persons to serve as directors, officers and key employees who,
through their efforts and expertise, can make a significant contribution to the
success of the Company.
 
     The Indemnification Agreements are intended to complement the indemnity and
other protection available under applicable law, Anergen Delaware's Certificate
of Incorporation and Bylaws, and to provide for indemnification of indemnitees
to the fullest extent permitted by applicable law.
 
INDEMNIFICATION AGREEMENTS
 
     The Indemnification Agreements provide the indemnitees with the maximum
indemnification allowed under applicable law. Since the Delaware statute is
non-exclusive, it is possible that certain claims beyond the scope of the
statute may be indemnifiable. The Indemnification Agreements provide a scheme of
indemnification which may be broader than that specifically provided by Delaware
law. It has not yet been determined, however, to what extent the indemnification
expressly permitted by Delaware law may be expanded, and therefore the scope of
indemnification provided by the Indemnification Agreements may be subject to
future judicial interpretation.
 
     The Indemnification Agreements provide that Anergen Delaware shall
indemnify an indemnitee who is or was a party or is threatened to be made a
party to any threatened, pending or completed action, suit, appeal, arbitration
or other proceeding of any nature whether civil, criminal, administrative or
investigative by reason of the fact that the indemnitee is or was a director,
officer, key employee or agent of Anergen Delaware or any subsidiary of Anergen
Delaware. Anergen Delaware shall advance all expenses, judgments, fines,
penalties and amounts paid in settlement (including taxes imposed on the
indemnitee on account of receipt of such payouts) incurred by the indemnitee in
connection with the investigation, defense, settlement or appeal of any civil or
criminal action or proceeding as described above. The indemnitee shall repay
such amounts advanced only if it ultimately shall be determined that he or she
is not entitled to be indemnified by Anergen Delaware. The advances paid to the
indemnitee by Anergen Delaware shall be delivered within thirty (30) days
following a written request by the indemnitee. Any award of indemnification to
an indemnitee, if not covered by insurance, would come directly from the assets
of Anergen Delaware, thereby affecting a stockholder's investment.
 
     The Indemnification Agreements set forth a number of procedural and
substantive matters which are not addressed or are addressed in less detail in
Delaware law, including the following:
 
     First, any dispute regarding the terms of the Indemnification Agreements
must be resolved exclusively by and through final and binding arbitration
("Arbitration") in Wilmington, Delaware (with certain exceptions). The Company
will reimburse the indemnitee for the expenses (including attorneys' fees)
incurred in such
                                       33
<PAGE>   36
 
arbitration to the full extent of such expenses if the indemnitee is awarded 50%
or more of the monetary value of his or her claim, or if not, to the extent such
expenses are determined by the arbitrators to be allocable to the Company.
 
     Second, the Indemnification Agreements explicitly provide for partial
indemnification of costs and expenses in the event that an indemnitee is not
entitled to full indemnification under the terms of the Indemnification
Agreements. Delaware law does not specifically address this issue. It does,
however, provide that to the extent that an indemnitee has been successful on
the merits, he or she shall be entitled to such indemnification.
 
     Third, in the event Anergen Delaware shall be obligated to pay the expenses
of any proceeding against the indemnitee, Anergen Delaware shall be entitled to
assume the defense of such proceeding, with counsel reasonably satisfactory to
the indemnified party, upon the delivery to the indemnitee of written notice of
its election to do so. Anergen Delaware shall have the right to conduct such
defense as it sees fit in its sole discretion, including the right to settle any
claim against indemnitee without the consent of the indemnitee.
 
     Fourth, indemnification provided by the Indemnification Agreements is not
exclusive of any rights to which the indemnitee may be entitled under Anergen
Delaware's Certificate of Incorporation, its Bylaws, any agreement, any vote of
stockholders or disinterested directors, Delaware law, or otherwise. The
indemnification provided under the Indemnification Agreements continues for any
action taken or not taken while serving in an indemnified capacity even though
the indemnitee may have ceased to serve in such capacity at the time of the
action, suit or other covered proceeding.
 
     Finally, the Indemnification Agreements provide for certain exceptions to
indemnification which include the following: (a) indemnification for liabilities
to the extent that payment is made under an insurance policy obtained by the
Company; (b) indemnification for liabilities to the extent that payment is made
by the Company under its Certificate of Incorporation, Bylaws, the Delaware
General Corporation Law, or otherwise than pursuant to the Indemnification
Agreements; (c) indemnification for liabilities to the extent that they are
determined by Arbitration to be based upon the illegal gain of personal profit
by the indemnitee; (d) indemnification for any claim for recovery of Company
profits arising in violation of Section 16(b) of the Securities Exchange Act of
1934, as amended; (e) where the conduct of the indemnitee has been determined by
Arbitration to constitute bad faith or active and material dishonesty, in either
such case material to the cause of action at issue; or (f) to the extent such
indemnification has been determined by Arbitration to be unlawful.
 
     The proposed Indemnification Agreements, together with the limitations on
the directors' liability provided by Anergen Delaware's Certificate of
Incorporation and Bylaws, reduce significantly the number of instances in which
directors might be held liable to Anergen Delaware for monetary damages for
breach of their fiduciary duties. Therefore, the current directors of Anergen
Delaware have a direct personal interest in the approval of the Indemnification
Agreements.
 
     The foregoing discussion of the indemnification agreements is qualified in
its entirety by reference to the form of indemnification agreement attached to
this proxy statement as Exhibit D, which you are urged to read and consider
carefully.
 
     At present there is no pending litigation or proceeding involving an
indemnitee where indemnification would be required or permitted under the
Indemnification Agreements. The Company is not aware of any threatened
litigation or proceeding which may result in a claim for indemnification under
the Indemnification Agreements by an indemnitee.
 
INDEMNIFICATION OF LIABILITIES UNDER THE SECURITIES ACT OF 1933
 
     The Securities and Exchange Commission has expressed its opinion that
indemnification of directors, officers and controlling persons of the Company
against liabilities arising under the Securities Act of 1933, as amended (the
"Act") is against public policy as expressed in the Act and is, therefore,
unenforceable. In the event that a claim for indemnification against such
liabilities (other than the payment by the Company of expenses incurred or paid
by an indemnitee of Anergen Delaware in the successful defense of any such act
or
                                       34
<PAGE>   37
 
proceeding) is asserted by such indemnitee in connection with securities which
have been registered by Anergen Delaware, Anergen Delaware will, unless in the
opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.
 
REQUIRED VOTE
 
     The affirmative vote of a majority of the votes cast and held by
disinterested shareholders will be required under California law to approve the
form of the Indemnification Agreement. Since each director and officer is an
interested party with respect to the Indemnification Agreements, shares owned
directly or indirectly by any director or officer may not be voted on this
proposal. For this purpose, the "votes cast" are defined under California law to
be the shares of the Company's Common Stock represented and voting in person or
by proxy at the Annual Meeting. In addition, the affirmative votes must
constitute at least a majority of the required quorum, which quorum is a
majority of the shares outstanding which are held by disinterested shareholders
on the record date for the meeting.
 
     THE BOARD OF DIRECTORS RECOMMENDS THAT SHAREHOLDERS VOTE "FOR" APPROVAL OF
THE FORM OF INDEMNIFICATION AGREEMENT.
 
                                       35
<PAGE>   38
 
                                 PROPOSAL NO. 6
 
             APPROVAL OF AMENDMENT TO AMENDED AND RESTATED ARTICLES
            OF INCORPORATION TO EFFECT REVERSE SPLIT OF COMMON STOCK
 
     The Board of Directors believes that it is in the best interests of the
Company and its shareholders to effect a reverse stock split (the "Reverse Stock
Split") of one share of reconstituted Common Stock for every two to five shares
of Common Stock that are currently issued and outstanding, with the precise
number of shares of Common Stock to be converted into each reconstituted share
of Common Stock (the "Split Factor") to be determined by the board of directors
at a later time.
 
     If this Proposal No. 6 and Proposal No. 4 (relating to the Reincorporation)
are approved, the Board of Directors intends to effect the Reverse Stock Split
after the Reincorporation. The Board of Directors reserves the right, however,
to decide at a later date to effect the Reverse Stock Split before the
Reincorporation by amending the Company's Amended and Restated Articles of
Incorporation. Accordingly, the shareholders' approval of this Proposal shall
include approval of an amendment to the Company's current Amended and Restated
Articles of Incorporation (if effected prior to Reincorporation) and to the
Certificate of Incorporation (if effected in connection with or following
Reincorporation). Thus, any reference to an amendment shall include both an
amendment to the Company's current Amended and Restated Articles of
Incorporation (if the Reverse Stock Split is effected prior to Reincorporation)
and an amendment to the Delaware Certificate of Incorporation (if the
Reincorporation is approved and the Reverse Stock Split is effected in
connection therewith or following Reincorporation).
 
     In order to effect the Reverse Stock Split, the shareholders are being
asked to approve an Amendment to the Company's Amended and Restated Articles of
Incorporation or the Certificate of Incorporation (following reincorporation),
as the case may be (the "Certificate Amendment"). The Board of Directors of the
Company believes that the Reverse Stock Split is the best interests of both the
Company and its shareholders, and has unanimously approved the Certificate
Amendment. The Board of Directors reserves the right, notwithstanding
shareholder approval and without further action by the shareholders, to decide
not to proceed with the Reverse Stock Split, if, at any time prior to effecting
such Reverse Stock Split it determines, in its sole discretion, that it is no
longer in the best interests of the Company and its shareholders.
 
EFFECT OF REVERSE STOCK SPLIT
 
     The Company is currently authorized to issue 40,000,000 shares of Common
Stock, of which 18,851,000 shares were issued and outstanding as of the Record
Date. The Company is further authorized to issue 10,000,000 shares of Preferred
Stock, of which 1,157,894 shares are designated as Series A-1 Preferred Stock,
740,740 shares are designated as Series A-2 Preferred Stock, 3,002,648 shares
are designated as Series B Preferred Stock and 15,000 shares are designated as
Series C Preferred Stock. Such series of Preferred Stock were previously
outstanding immediately prior to the Company's initial public offering, and in
connection therewith, all such outstanding series of Preferred Stock
automatically converted to Common Stock. No shares of Preferred Stock were
issued and outstanding as of the Record Date. Accordingly, in connection with
the Reincorporation, the Company's Certificate of Incorporation will not contain
reference to any series of Preferred Stock. If effected, the Reverse Stock Split
would reduce the number of outstanding shares of Common Stock to a range of
approximately 9,425,500 to 3,770,200 (depending on the Split Factor selected by
the Board) but will not affect the number of authorized shares of Common Stock
even though the number of shares outstanding will decrease. The proposed Reverse
Stock Split also will not affect the number of authorized shares of Preferred
Stock. Therefore, the Company as a result of the Reverse Stock Split will have
additional shares authorized for issuance than is currently available.
Notwithstanding the foregoing, due to the Company's capital requirements, the
Company believes it is in the Company's interest to increase the number of
authorized shares to enable the Company to issue additional shares of Common
Stock to meet its capital requirements. See Proposal No. 7 for greater detail
regarding the proposed amendment to increase the authorized number of shares. In
addition, the proposed Reverse Stock Split would not affect any shareholder's
proportionate equity interest in the Company. None of the rights currently
accruing to holders of Common Stock or Preferred Stock will be affected by the
Reverse Stock Split.
 
                                       36
<PAGE>   39
 
     The following table illustrates the principal effects of the Reverse Stock
Split of the Company's Common Stock (without giving effect to any adjustments
for fractional shares):
 
<TABLE>
<CAPTION>
                                                       NUMBER OF SHARES AS OF MARCH 20, 1998
                                                   ---------------------------------------------
                                                   PRIOR TO REVERSE
                                                     STOCK SPLIT       AFTER REVERSE STOCK SPLIT
                                                   ----------------    -------------------------
<S>                                                <C>                 <C>
Authorized
  Preferred Stock..............................       10,000,000             10,000,000
  Common Stock.................................       40,000,000             60,000,000(1)
Outstanding
  Preferred Stock..............................               --                 --
  Common Stock.................................       18,851,000       3,770,200 - 9,425,500(2)
</TABLE>
 
<TABLE>
<CAPTION>
                                                  PRIOR TO REVERSE
              FINANCIAL DATA(3)                     STOCK SPLIT       AFTER REVERSE STOCK SPLIT
              -----------------                   ----------------    -------------------------
<S>                                               <C>                 <C>
Shareholders' equity..........................      $ 7,787,000                  $  7,787,000
Shareholders' equity per share................      $      0.41                 $ 0.82 - 2.05
Net loss......................................      $(8,430,000)                $ (8,430,000)
Basic and diluted net loss per share..........      $     (0.45)               $(0.90 - 2.25)
</TABLE>
 
- ---------------
(1) Reflects the increase in the authorized number of shares from 40,000,000 to
    60,000,000 in connection with the proposed amendment to the Certificate of
    Incorporation to effect such increase. See "PROPOSAL 7 -- APPROVAL OF
    AMENDMENT TO AMENDED AND RESTATED ARTICLES OF INCORPORATION INCREASING THE
    NUMBER OF AUTHORIZED SHARES OF COMMON STOCK." If such proposal, however, is
    not approved by the shareholders, the number of authorized shares shall
    remain the same at 40,000,000.
 
(2) Reflects the range of shares of Common Stock outstanding which will vary
    based on the Split Factor selected by the Board of Directors.
 
(3) As of December 31, 1997 and subject to adjustment resulting from the
    repurchase of fractional shares.
 
BACKGROUND REASONS FOR THE PROPOSAL
 
     The Board of Directors believes that this action may increase the price per
share of the Company's Common Stock and thus may enhance the marketability of
the Company's Common Stock to the financial community and the investing public
at large. The Board of Directors believes that the relatively low per share fair
market value of the Common Stock, when compared with the market prices of the
common stock of publicly-held companies in the same or comparable industries,
impairs the marketability of the Common Stock and creates a negative impression
with respect to the Company. These factors adversely affect not only the
liquidity of the Common Stock, but also the Company's ability to raise capital
through further sales of equity securities. The anticipated increase in the
trading price of the Company's stock as a result of the Reverse Stock Split is
expected to enhance the marketability of the stock to the financial community
and the investing public at large.
 
     Additionally, the Board of Directors believes that this action may improve
the liquidity of the Company's Common Stock. The policies and practices of many
brokerage houses tend to discourage brokers within those firms from dealing in
lower-priced stocks. Some of such policies and practices pertain to the payment
of broker's commissions and to time-consuming procedures that make handling of
lower-priced stocks economically unattractive to brokers. The structure of
trading commissions also tends to have an adverse impact upon holders of
lower-priced stock because the brokerage commission payable on its sale
generally represents a higher percentage of the sales price than on
higher-priced stock.
 
     The Board is hopeful that the Reverse Stock Split will result in a trading
price for the Company's Common Stock that will better suit the preferences of
institutional investors and brokerage firms described above and mitigate the
adverse impact of trading commissions on the potential market for the Company's
 
                                       37
<PAGE>   40
 
shares. However, there can be no assurance that the increased market price of
the Common Stock after the Reverse Stock Split will enhance the aggregate
capitalization of the Company or improve the liquidity of the Company's stock.
 
     The Company is not aware of any current efforts to accumulate Common Stock
or obtain control of the Company, and the Reverse Stock Split is not intended to
be an anti-takeover device. The Reverse Stock Split is being proposed with a
view toward enhancing marketability of the Company's Common Stock by obtaining a
Common Stock price in a range more acceptable to the investment community.
 
EXECUTION AND CONSEQUENCES OF REVERSE STOCK SPLIT
 
  Exchange of Stock Certificates
 
     Each stock certificate representing issued and outstanding shares of Common
Stock prior to the effective date of the Reverse Stock Split will, after such
effective date, represent the appropriate number of shares of Common Stock
reflecting the Reverse Stock Split. IT WILL NOT BE NECESSARY FOR SHAREHOLDERS TO
EXCHANGE THEIR EXISTING STOCK CERTIFICATES. However, shareholders may exchange
their certificates if they so choose.
 
  Payment for Fractional Shares
 
     No scrip or fractional certificates will be issued in the Reverse Stock
Split. Instead, shareholders who would be entitled to receive fractional shares
because they hold a number of shares not evenly divisible by the Split Factor
will be entitled to receive a cash payment in lieu thereof at a price equal to
the fair market value of the stock as determined by the Board on the effective
date of the Reverse Stock Split. The ownership of a fractional interest will not
give the holder thereof any voting, dividend or other rights except to receive
payment therefor as described herein.
 
     Shareholders should be aware that, under the escheat laws of the various
jurisdictions where shareholders reside, where the Company is domiciled and
where funds will be deposited, sums due for fractional interests that are not
timely claimed after the effective date of the Reverse Stock Split may be
required to be paid to the designated agent for each such jurisdiction, unless
correspondence has been received by the Company or its transfer agent, as the
case may be, concerning ownership of such funds within the time permitted in
such jurisdictions. Thereafter, shareholders otherwise entitled to receive such
funds will have to seek to obtain them directly from the state to which they are
paid.
 
  Certain Federal Income Tax Consequences
 
     The following description of federal income tax consequences of the Reverse
Stock Split is based on the Internal Revenue Code, the applicable Treasury
Regulations promulgated thereunder, judicial authority and current
administrative rulings and practices as in effect on the date of this Proxy
Statement. This discussion is for general information only and does not address
all the tax consequences that may be relevant to a particular shareholder (such
as non-resident aliens, broker-dealers or insurance companies). Furthermore, no
foreign, state or local tax consequences are discussed herein. ACCORDINGLY,
SHAREHOLDERS ARE URGED TO CONSULT THEIR OWN TAX ADVISORS TO DETERMINE THE
SPECIFIC TAX CONSEQUENCES OF THE REVERSE STOCK SPLIT TO THEM.
 
     The exchange of shares of stock for shares of post-split stock will not
result in recognition of gain or loss (except in the case of cash received for
fractional shares as described below). The holding period of the shares of
post-split stock will include the shareholder's holding period for the shares of
stock exchanged therefor, reduced by the tax basis allocable to the receipt of
cash in lieu of fractional shares.
 
     A shareholder who receives cash in lieu of fractional shares will be
treated as if the Company has issued fractional shares to him or her and then
immediately redeemed them for cash. Such shareholder should generally recognize
gain or loss, as the case may be, measured by the difference between the amount
of cash received and the basis of such shareholder's pre-split stock allocable
to such fractional shares, had such fractional shares actually been issued. Such
gain or loss will be capital gain or loss (if such stock was held as a
 
                                       38
<PAGE>   41
 
capital asset), and any such capital gain or loss will generally be long-term
capital gain or loss to the extent such shareholder's holding period for his or
her stock exceeds 18 months.
 
VOTE REQUIRED
 
     Approval of the Reverse Stock Split and adoption of the Certificate
Amendment require the affirmative vote of the holders of not less than a
majority of the outstanding shares of the Company's Common Stock. Abstentions
and broker non-votes will be counted as votes against adoption of the
Certificate Amendment. Any shareholder entitled to vote may vote part of his or
her shares in favor of the proposed Certificate Amendment and refrain from
voting shares against the proposed Amendment. In such a case, the shareholder
must specify the number of shares which he or she is voting affirmatively or
else it will be conclusively presumed that such shareholder intended to vote all
of his or her shares in favor the proposed Certificate Amendment.
 
     THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT SHAREHOLDERS VOTE "FOR"
ADOPTION OF THE PROPOSAL TO EFFECT A REVERSE STOCK SPLIT OF THE COMPANY'S COMMON
STOCK.
 
                                       39
<PAGE>   42
 
                                 PROPOSAL NO. 7
 
                            APPROVAL OF AMENDMENT TO
                 AMENDED AND RESTATED ARTICLES OF INCORPORATION
           INCREASING THE NUMBER OF AUTHORIZED SHARES OF COMMON STOCK
 
PROPOSED AMENDMENT
 
     Proposal No. 7 is to amend the Company's current Amended and Restated
Articles of Incorporation (the "Articles"), or if the Reincorporation Proposal
described in Proposal No. 4 is approved by the shareholders, the Delaware
Certificate of Incorporation (the "Certificate"), for the purpose of increasing
the total number of shares of Common Stock the Company is authorized to issue
from 40,000,000 shares to 60,000,000 shares. Accordingly, references to such
amendment to the Articles or to the Certificate, as applicable, shall refer to
the "Amendment." Subject to shareholder approval of the Amendment, the Board
shall retain the discretion to effect the Amendment by either amending the
Articles prior to the proposed Reincorporation or amending the Certificate in
connection with the Reincorporation. The Company's current Articles authorize
the Company to issue 10,000,000 shares of Preferred Stock, no par value per
share, and 40,000,000 shares of Common Stock, no par value per share. In
February 1998, the Board of Directors authorized an amendment to the Articles
(or an amendment to the Certificate if the Reincorporation Proposal is approved)
to increase the authorized number of shares of Common Stock to 60,000,000
shares.
 
REASONS FOR THE AMENDMENT
 
     The Company believes it is important to retain a significant reserve of
authorized but unissued Common Stock that could be used to raise additional
capital through the sale of securities, declare stock dividends or stock splits,
acquire another company or its business or assets, create negotiating leverage
and flexibility in the event of an unfriendly takeover bid or establish a
strategic relationship with a corporate partner, among other uses. In
particular, the Company believes that maintaining a sufficient reserve of
authorized but unissued Common Stock is important to preserving the Company's
flexibility to enter into future financing opportunities. The Company expects to
seek to raise additional capital through equity or debt financing, research and
development collaborations with corporate partners or through other sources.
 
CURRENT NUMBER OF SHARES OUTSTANDING AND SUBJECT TO OPTIONS
 
     As of February 28, 1998, 18,851,000 shares of Common Stock were issued and
outstanding, approximately 1,593,701 additional shares were issuable upon
exercise of outstanding options or purchase rights and approximately 971,591
shares were reserved for future grants under the Company's stock plans. As of
February 28, 1998, no shares of Preferred Stock were outstanding and no shares
of Preferred Stock were subject to options.
 
TEXT OF AMENDMENT
 
     Under the proposed Amendment, the first two sentences of Article III of the
Articles (or, if the Reincorporation Proposal is adopted, the first two
sentences of Article IV of the Certificate) would read substantially as follows:
 
     "This Company is authorized to issue two classes of shares to be designated
     respectively Common Stock ("Common Stock") and Preferred Stock ("Preferred
     Stock"). The total number of shares of all classes of stock which the
     Company shall have authority to issue is Seventy Million (70,000,000),
     consisting of Sixty Million (60,000,000) shares of Common Stock and Ten
     Million (10,000,000) shares of Preferred Stock."
 
EFFECT OF AMENDMENT
 
     If approved, the proposed amendment to the Articles (or to the Certificate
if the Reincorporation Proposal is approved) would authorize additional shares
of Common Stock that will be available in the event
 
                                       40
<PAGE>   43
 
that the Board of Directors determines to authorize stock dividends or stock
splits, to raise additional capital through the sale of securities, to acquire
another company or its business or assets, to create negotiating leverage and
flexibility in the event of an unfriendly takeover bid or to establish a
strategic relationship with a corporate partner, among other uses. Any
additional equity financings may be dilutive to shareholders, and a debt
financing, if available, may involve restrictions on stock dividends and other
restrictions on the Company.
 
     If the Amendment is adopted, 20,000,000 additional shares of Common Stock
of the Company will be available for issuance at the discretion of the Board of
Directors, except that certain large issuances of shares may require shareholder
approval in accordance with the requirements of The Nasdaq National Market and
certain stock-based employee benefit plans may require shareholder approval in
order to obtain desirable treatment under tax or securities laws and accounting
regulations. As discussed in Proposal No. 6 regarding the proposed Reverse Stock
Split, the Company will also have between 9,425,500 and 15,080,800 additional
shares available for issuance following the Reverse Stock Split depending on the
Split Factor selected by the Board of Directors. The additional shares available
as a result of the Reverse Stock Split is in addition to the 20,000,000
additional shares resulting from the Amendment.
 
     The Board of Directors believes it desirable that the Company have the
flexibility to issue the additional shares as described above. As is typical in
publicly held technology companies, the holders of Common Stock have no
preemptive rights to purchase any stock of the Company. Shareholders should be
aware that the issuance of additional shares could have a dilutive effect on
earnings per share and on the equity ownership of the present holders of Common
Stock. No actions are currently being taken with respect to any large issuance
of additional shares.
 
     The flexibility of the Board of Directors to issue additional shares of
stock could also enhance the Board's ability to negotiate on behalf of the
shareholders in an unfriendly takeover situation. Although it is not the purpose
of the proposed Amendment, the authorized but unissued shares of Common Stock
(as well as the existing authorized but unissued shares of Preferred Stock) also
could be used by the Board of Directors to discourage, delay or make more
difficult a change in the control of the Company. The Board of Directors is not
aware of any pending or proposed effort to acquire control of the Company.
 
VOTE REQUIRED
 
     The approval of the Amendment requires the affirmative vote of a majority
of the outstanding shares of Common Stock of the Company. An abstention or
nonvote is not an affirmative vote and, therefore, will have the same effect as
a vote against the proposal. Any shareholder entitled to vote may vote part of
his or her shares in favor of the proposed amendment and refrain from voting
shares against the proposed amendment. In such a case, the shareholder must
specify the number of shares which he or she is voting affirmatively or else it
will be conclusively presumed that such shareholder intended to vote all of his
or her shares in favor of the proposed amendment.
 
     THE COMPANY'S BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" APPROVAL OF THE
AMENDMENT TO THE COMPANY'S AMENDED AND RESTATED ARTICLES OF INCORPORATION OR THE
CERTIFICATE OF INCORPORATION, WHERE APPLICABLE, TO INCREASE THE AUTHORIZED
SHARES OF COMMON STOCK FROM 40,000,000 SHARES TO 60,000,000 SHARES.
 
                                       41
<PAGE>   44
 
                                 PROPOSAL NO. 8
 
              CONFIRMATION OF APPOINTMENT OF INDEPENDENT AUDITORS
 
     The Board of Directors has selected Ernst & Young LLP to audit the
financial statements of the Company for the year ending December 31, 1998, and
recommends that the shareholders confirm the selection. In the event of a
negative vote, the Board will reconsider its selection.
 
     Ernst & Young LLP has audited the Company's financial statements since its
inception. Representatives of Ernst & Young LLP are expected to be present at
the meeting, will have the opportunity to make a statement if they so desire,
and are expected to be available to respond to appropriate questions.
 
REQUIRED VOTE
 
     Ratification of the selection of Ernst & Young LLP as the Company's
independent auditors requires a majority of the votes cast at the Annual
Meeting.
 
     THE BOARD OF DIRECTORS RECOMMENDS THAT SHAREHOLDERS VOTE "FOR" THE
RATIFICATION OF THE SELECTION OF ERNST & YOUNG LLP.
 
                                       42
<PAGE>   45
 
                    EXECUTIVE COMPENSATION AND OTHER MATTERS
 
EXECUTIVE COMPENSATION
 
     Summary Compensation Table. The following table sets forth the compensation
paid by the Company for each of the three years in the period ended December 31,
1997 to (i) the Chief Executive Officer of the Company, (ii) the four most
highly compensated executive officers of the Company as of the end of fiscal
year 1997, and (iii) the executive officer who would have been among the four
most highly compensated executive officers as of the end of fiscal year 1997 but
for the fact that he resigned before the end of the year (collectively, the
"Named Executive Officers"):
 
<TABLE>
<CAPTION>
                                                                           LONG-TERM
                                                   ANNUAL COMPENSATION    COMPENSATION
                                                   --------------------   ------------
                                                                            AWARD OF
                                                                            OPTIONS
                                                                             (# OF          ALL OTHER
       NAME AND PRINCIPAL POSITION          YEAR    SALARY    BONUS(1)      SHARES)      COMPENSATION(2)
       ---------------------------          ----   --------   ---------   ------------   ----------------
<S>                                         <C>    <C>        <C>         <C>            <C>
Barry M. Sherman, M.D.....................  1997   $262,250    $31,250           --           $5,880
  President, Chief Executive Officer        1996    149,680     36,500      400,000            3,310
  and Secretary                             1995         --         --           --               --
David V. Smith(3).........................  1997     82,872      5,000       75,000            1,831
  Vice President, Finance and               1996         --         --           --               --
  Chief Financial Officer                   1995         --         --           --               --
John W. Varian(4).........................  1997    200,199         --      117,500            3,869
  Vice President, Finance and               1996    145,000     25,000       25,000            3,054
  Chief Financial Officer                   1995    135,000     45,000      130,740            3,520
Gilbert R. Mintz, Ph.D. (5)...............  1997    122,250      5,000       50,000            2,218
  Vice President, Marketing and             1996         --         --           --               --
  Business Development                      1995         --         --           --               --
Michael G. Shulman, M.D (6)...............  1997    155,000         --       50,000            3,939
  Vice President, Clinical Development      1996         --         --           --               --
                                            1995         --         --           --               --
Jeffrey L. Winkelhake, Ph.D...............  1997    160,000     30,000           --            2,938
  Vice President, Pharmaceutical            1996    153,750     30,000           --            3,191
  Development                               1995    145,000     45,000      130,000            3,719
</TABLE>
 
- ---------------
(1) Represents payments for achievements of corporate objectives. The amounts
    stated for Mr. Smith and Dr. Mintz represent one-time signing bonuses of
    $5,000.
 
(2) Amounts included in "All Other Compensation" for 1997 represent Company
    matching contributions to the Anergen Retirement Savings Plan ("401(k)
    Contributions"), payments by the Company on term life insurance policies
    ("Life Insurance Payments"), and relocation expenses. Specifically, the
    amount stated for Dr. Sherman in 1997 consists of 401(k) Contributions of
    $2,570 and Life Insurance Payments of $3,310; the amount stated for Mr.
    Smith in 1997 consists of 401(k) Contributions of $1,500 and Life Insurance
    Payments of $331; the amount stated for Mr. Varian in 1997 consists of
    401(k) Contributions of $3,308 and Life Insurance Payments of $561; the
    amount stated for Dr. Mintz in 1997 consists of 401(k) Contributions of
    $1,500 and Life Insurance Payments of $718; the amounts stated for Dr.
    Shulman in 1997 consists of 401(k) Contributions of $1,450 and Life
    Insurance Payments of $2,489; and the amount stated for Dr. Winkelhake in
    1997 consists of 401(k) Contributions of $1,733 and Life Insurance Payments
    of $1,205.
 
(3) Mr. Smith joined the Company in June 1997 as Vice President, Finance and
    Chief Financial Officer.
 
(4) Mr. Varian resigned as Vice President, Finance and Chief Financial Officer
    in April 1997.
 
(5) Dr. Mintz joined the Company in March 1997 as Vice President, Marketing and
    Business Development.
 
(6) Dr. Shulman joined the Company in January 1997 as Vice President, Clinical
    Development.
 
                                       43
<PAGE>   46
 
     Option Grants in Fiscal Year 1997. The following table sets forth each
grant of stock options made during the year ended December 31, 1997 to each
Named Executive Officer:
 
<TABLE>
<CAPTION>
                                                INDIVIDUAL GRANTS                       POTENTIAL REALIZABLE
                             --------------------------------------------------------     VALUE AT ASSUMED
                              NUMBER OF      % OF TOTAL                                 ANNUAL RATES OF STOCK
                             SECURITIES       OPTIONS                                    PRICE APPRECIATION
                             UNDERLYING      GRANTED TO     EXERCISE OR                  FOR OPTION TERM(3)
                               OPTIONS      EMPLOYEES IN       BASE        EXPIRATION   ---------------------
           NAME              GRANTED(1)         1997         PRICE(2)         DATE         5%          10%
           ----              -----------    ------------    -----------    ----------   ---------   ---------
<S>                          <C>            <C>             <C>            <C>          <C>         <C>
Barry M. Sherman, M.D......        --             --              --             --           --          --
David W. Smith.............    75,000          9.52%          $2.625        7/28/07     $123,814    $313,768
John W. Varian(4)..........    25,000           3.17           9.000         5/1/99       23,063      47,250
                               12,500           1.59           5.500         5/1/99        7,047      14,438
                               25,000           3.17           2.750         5/1/99        7,047      14,438
                               30,000           3.81           3.250         5/1/99        9,994      20,475
                               25,000           3.17           3.625         5/1/99        9,289      19,031
Gilbert R. Mintz, Ph.D.....    50,000           6.35           2.625         5/2/07       82,542     209,179
Michael G. Shulman, M.D....    50,000           6.35           3.875        2/12/07      121,848     308,788
Jeffrey L. Winkelhake,             --             --              --             --           --          --
  Ph.D.....................
</TABLE>
 
- ---------------
(1) The listed options become exercisable as to 1/48th of the shares subject to
    the option at the end of each month after the date of grant, with full
    vesting occurring four years after the date of grant. Under the terms of the
    Company's 1988 Stock Option Plan and 1996 Stock Plan, the Board of Directors
    retains discretion, subject to plan limits, to modify the terms of
    outstanding options and to reprice the options.
 
(2) The exercise price and tax withholding obligations related to exercise may
    be paid, in some cases, by delivery of other shares or by offset of the
    shares subject to the options.
 
(3) The dollar amounts under these columns are the result of calculations at the
    5% and 10% rates set by the SEC and therefore are not intended to forecast
    the possible future appreciation, if any, of the Company's stock price. The
    Company did not use an alternative formula for a grant date valuation, as
    the Company does not believe that any formula will determine with reasonable
    accuracy a present value based on future unknown or volatile factors.
 
(4) In connection with Mr. Varian's termination of employment, the Company
    agreed to amend certain option agreements to accelerate the unvested portion
    of such options. The table reflects the number of shares which were subject
    to the unvested portions of such options that upon amendment became
    immediately exercisable.
 
     Aggregated Option Exercises in Last Fiscal Year and Fiscal Year-End
Values. The following table sets forth, for each of the Named Executive
Officers, each exercise of stock options during the year ended December 31, 1997
and the year-end value of unexercised options:
 
<TABLE>
<CAPTION>
                                 SHARES                    NUMBER OF SECURITIES       VALUE(2) OF UNEXERCISED
                                ACQUIRED                  UNDERLYING UNEXERCISED      IN-THE-MONEY OPTIONS AT
                                   ON         VALUE         OPTIONS AT YEAR-END              YEAR-END
             NAME               EXERCISE   REALIZED(1)   EXERCISABLE/UNEXERCISABLE   EXERCISABLE/UNEXERCISABLE
             ----               --------   -----------   -------------------------   -------------------------
<S>                             <C>        <C>           <C>                         <C>
Barry M. Sherman, M.D. .......   --            --          158,329 / 241,671           $336,449 / $513,551
David W. Smith................   --            --           9,372 / 65,628              19,916 / 139,460
John W. Varian................   --            --            117,500 / --                 249,688 / --
Gilbert R. Mintz, Ph.D. ......   --            --           9,378 / 40,622              19,928 / 86,322
Michael G. Shulman, M.D. .....   --            --           11,462 / 38,538             24,357 / 81,893
Jeffrey L. Winkelhake,
  Ph.D. ......................   --            --           89,898 / 21,871             191,033 / 46,476
</TABLE>
 
- ---------------
(1) Based on the closing price of the Company's Common Stock on the date of
    exercise.
 
(2) Based on a fair market value of $2.125 which was the closing price of the
    Company's stock on December 31, 1997.
 
                                       44
<PAGE>   47
 
COMPENSATION OF DIRECTORS
 
     Directors currently receive no fees for services provided in that capacity
but are reimbursed for out-of-pocket expenses in connection with attendance at
Board of Directors' meetings. During 1997, Dr. McConnell was paid $12,000 by the
Company in connection with consulting services provided to the Company. Outside
directors are granted nonstatutory stock options under the 1995 Director Option
Plan. Currently there are six outside directors, but only two have elected to
receive grants of options under the 1995 Director Option Plan. Please see
"Employee Benefit Plans -- 1995 Director Option Plan" for information with
respect to the 1995 Director Option Plan.
 
EMPLOYMENT CONTRACTS, TERMINATION AND CHANGE OF CONTROL ARRANGEMENTS
 
     In May 1996, the Company entered into an employment agreement with Barry M.
Sherman, M.D., effective in May 1996 providing for a base salary of $250,000 per
year and an option to purchase 400,000 shares of Common Stock at an exercise
price of $3.75 per share subject to a four-year vesting schedule. The term of
Dr. Sherman's employment agreement is through May 2000, subject to extension by
mutual agreement of both parties and subject to a voluntary termination by Dr.
Sherman or earlier termination by the Company with or without cause. If the
Company terminates Dr. Sherman without cause or constructively terminates Dr.
Sherman, Dr. Sherman is entitled to twelve months severance pay and accelerated
vesting of the lesser of the unvested portion or one-quarter of the options
referred to above (or the lesser of the unvested portion or one-half of such
options if the termination occurs after a change of control). At the end of
twelve months, Dr. Sherman is eligible to receive a performance bonus of up to
twenty-five percent of his annual salary based on full or partial completion of
certain goals established by mutual agreement of Dr. Sherman and the Board of
Directors.
 
     The Company has entered into a transition agreement and mutual release (the
"Transition Agreement") with Mr. Varian in connection with Mr. Varian's
termination of employment with the Company on April 30, 1997 (the "Termination
Date"). Pursuant to the Transition Agreement, the Company paid Mr. Varian
$113,250 (less applicable withholdings), COBRA benefits until October 1997 and
immediately accelerated the vesting of all unvested shares of Mr. Varian's stock
options and extended the period of exercisability of all options to acquire
shares of the Common Stock to two years from the Termination Date.
 
     The 1995 Director Option Plan provides that upon a change in control of the
Company, the unvested portion of all outstanding options under such Plan shall
become immediately exercisable. The 1988 Stock Option Plan, the 1996 Stock Plan
and the 1992 Consultant Stock Plan each provides that in the event of a change
in control of the Company, outstanding stock options and stock purchase rights
under such Plans shall be assumed or equivalent options or rights shall be
substituted by the successor entity. If such successor corporation does not
agree to such assumption or substitution, the Company's Board of Directors must
provide for such options or rights to become immediately exercisable in full.
There are no other compensatory plans or arrangements with respect to an
executive officer that will result in payments upon resignation, retirement, or
any other termination of such executive officer's employment or from a change of
control of the Company.
 
REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS
 
     The Compensation Committee has been a standing committee of the Board of
Directors of Anergen, Inc. since prior to the Company's initial public offering
on October 10, 1991. Throughout its history, only "outside," nonemployee
directors have served on this committee. Among its other duties, the
Compensation Committee is charged with the responsibilities, subject to full
Board of Directors' approval, of establishing, periodically reevaluating and (as
appropriate) adjusting, and administering Company policies concerning the
compensation of management personnel, including the CEO and all other officers.
In discharging such duties, the Compensation Committee is responsible for
annually determining and recommending to the full Board the annual base salary
for each officer and for establishing the criteria under which cash incentive
bonuses may be paid to such officers for the year. In addition, the Committee is
responsible for administering the Company's Stock Option Plans.
 
                                       45
<PAGE>   48
 
     The Company uses a simple total compensation program that consists of cash-
and equity-based compensation. Having a compensation program that allows the
Company to successfully attract and retain key employees permits it to develop
its technology toward commercialization, enhance shareholder value, motivate
technological innovation, foster teamwork, and adequately reward employees.
 
     Cash Salaries and Bonuses. Base salaries for new officers are initially
established by evaluating the responsibilities of the position to be held and
the experience of the individual, and by reference to the competitive
marketplace for executive talent, including a comparison to base salaries for
comparable positions at other companies. Companies used in the comparison were
selected based upon comparable employee headcount, market capitalization and
stage of product progression. In determining its recommendations for annual
adjustment to officers' compensation packages, the Compensation Committee
focuses primarily on similar executive marketplace data, including survey
material on salary movements for peer executives, in determining base salary
adjustments. In the context of individual performance, Company performance,
survey data, and the responsibilities pertaining to a particular position, the
Chief Executive Officer recommended to the Committee a base salary for fiscal
1997 for each officer's position (excluding the Chief Executive Officer). The
Compensation Committee determined the Chief Executive Officer's salary
adjustment considering these same criteria. The officers' salaries for 1997
corresponded with the median range of comparable companies. When evaluating and
deciding upon cash bonuses, the Compensation Committee gives consideration to
the individual's contributions towards the Company's success in moving toward
its long-term goals during the fiscal year, the performance of the Common Stock
during that year, and its assessment of the quality of services rendered by the
officer. Because the Company is in the research and development stage the
typical financial performance methodology of evaluating the Company's
performance is not appropriate. Cash bonuses can be awarded at the Board's
discretion for exceptional contributions to the Company's success. The officers'
performance is directly related to corporate performance objectives, which are
defined based upon industry standards of progression towards the development of
pharmaceutical products, and bonuses are awarded based upon the achievement of
those objectives.
 
     Stock Option Program. The purpose of this program is to provide additional
incentives to employees who are expected to contribute materially to the
Company's success in the future. The Committee believes stock options encourage
the achievement of superior results over time and align officer and shareholder
interests. The option program also utilizes vesting periods to encourage key
employees to continue in the employ of the Company. The Company grants stock
options annually to a broad-based population of the total employee pool. The
size of the stock option grants to each officer are based upon the Board's
evaluation of the officer's contribution to the achievement of corporate
performance objectives. The Chief Executive Officer recommends to the Committee
proposed stock option grants for the Company's officers, other than the Chief
Executive Officer. Stock option grants to each officer other than the Chief
Executive Officer are reviewed and approved by the Committee in the context of
the following factors: the Company's performance to date relative to its
objectives, the responsibility level and performance of the officer, prior
option grants to the officer and the level of vested and unvested options. The
Compensation Committee determines the Chief Executive Officer's stock option
grant considering the same criteria.
 
     Compensation of Chief Executive Officer. The compensation of the Company's
Chief Executive Officer for 1997 was based upon the same general criteria as
described above for executive officers. Specifically, the Compensation Committee
considered several factors as important in determining the Chief Executive's
compensation in 1997. These factors included the attainment of certain research
and development objectives, the Company's progress in proceeding towards
clinical trials and its progress in ongoing clinical testing, the Committee's
assessment of the Company's efforts to consummate new corporate partnering
arrangements for product development and marketing, and the performance of the
Company's stock during the year. After considering these and other factors, the
Committee concluded that the Company made progress in proceeding toward these
goals in 1997 on which the Chief Executive Officer's compensation was based.
Based on these factors, the Board increased Dr. Sherman's annual base salary
from $250,000 in fiscal year 1996 to $262,250 in fiscal year 1997. The Board
determined not to grant additional options to Dr. Sherman in fiscal year 1997.
 
                                       46
<PAGE>   49
 
SUMMARY
 
     The members of the Compensation Committee of the Board of Directors believe
that the Company's compensation programs are successful in attracting and
retaining qualified employees and tying compensation directly to performance for
shareholders. We will continue to monitor closely the effectiveness and
appropriateness of each of the components of compensation to reflect changes in
the Company's business environment.
 
                                          Respectfully submitted,
 
                                          Harry H. Penner, Jr.
                                          James E. Thomas
                                          Nicole Vitullo
 
PERFORMANCE GRAPH
 
     The following graph shows a comparison of cumulative total shareholder
returns for the Company's Common Stock, the NASDAQ composite index for U.S.
companies ("Nasdaq"), and an index of NASDAQ-listed pharmaceutical companies
("Pharma") published by the Center for Research in Security Prices at the
University of Chicago and provided by Nasdaq to its members. The graph assumes
the investment of $100 on December 31, 1992. The performance shown is not
necessarily indicative of future performance.
 
[GRAPH]
 
COMPLIANCE WITH SECTION 16(a) OF THE EXCHANGE ACT
 
     Section 16(a) of the Exchange Act requires the Company's executive officers
and directors and persons who own more than ten percent of a registered class of
the Company's equity securities to file reports of ownership and changes in
ownership with the Securities and Exchange Commission ("SEC") and the National
Association of Securities Dealers, Inc. Executive officers, directors and
greater than ten percent shareholders are required by SEC regulation to furnish
the Company with copies of all Section 16(a) forms they file. Based solely on
its review of the copies of such forms received by it, or on written
representations from certain reporting persons, the Company believes that,
during the fiscal year ended December 31, 1997, all filing requirements were
complied with applicable to its executive officers and directors.
 
                                       47
<PAGE>   50
 
                                 OTHER MATTERS
 
     The Company knows of no other matters to be submitted to the meeting. If
any other matters properly come before the meeting, it is the intention of the
persons named in the enclosed proxy card to vote the shares they represent as
the Board of Directors may recommend.
 
                                          THE BOARD OF DIRECTORS
 
Dated: April 7, 1998
 
     THE COMPANY WILL MAIL WITHOUT CHARGE TO ANY SHAREHOLDER UPON WRITTEN
REQUEST A COPY OF THE COMPANY'S ANNUAL REPORT ON FORM 10-K FOR THE YEAR ENDED
DECEMBER 31, 1997, INCLUDING THE FINANCIAL STATEMENTS, SCHEDULES AND A LIST OF
EXHIBITS. REQUESTS SHOULD BE SENT TO INVESTOR RELATIONS, ANERGEN, INC., 301
PENOBSCOT DRIVE, REDWOOD CITY, CA 94063.
                                       48
<PAGE>   51
 
                                   EXHIBIT A
 
                          AGREEMENT AND PLAN OF MERGER
                               OF ANERGEN, INC.,
                            A DELAWARE CORPORATION,
                                      AND
                                 ANERGEN, INC.,
                            A CALIFORNIA CORPORATION
 
     THIS AGREEMENT AND PLAN OF MERGER dated as of                            ,
1998 (this "Agreement") is between Anergen, Inc., a Delaware corporation
("Anergen Delaware"), and Anergen, Inc., a California corporation ("Anergen
California"). Anergen Delaware and Anergen California are also referred to
herein as the "Constituent Corporations."
 
                                    RECITALS
 
     A. Anergen Delaware is a corporation duly organized and existing under the
laws of the State of Delaware and has authorized capital of 70,000,000 shares,
$.001 par value, of which 60,000,000 shares are designated "Common Stock" and
10,000,000 shares are designated "Preferred Stock." The Preferred Stock of
Anergen Delaware is undesignated as to series, rights, preferences, privileges
or restrictions. As of the date hereof, 100 shares of Common Stock were issued
and outstanding, all of which are held by Anergen California, and no shares of
Preferred Stock were issued and outstanding.
 
     B. Anergen California is a corporation duly organized and existing under
the laws of the State of California and has an authorized capital of 50,000,000
shares, no par value, of which 40,000,000 are designated "Common Stock" and
10,000,000 shares are designated "Preferred Stock," of which 1,157,894 shares
are designated as Series A-1 Preferred Stock, 740,740 shares are designated as
Series A-2 Preferred Stock, 3,002,648 shares are designated as Series B
Preferred Stock and 15,000 shares are designated as Series C Preferred Stock. As
of                            , 1998,                shares of Common Stock were
issued and outstanding, and no shares of Preferred Stock were issued and
outstanding.
 
     C. The Board of Directors of Anergen California has determined that, for
the purpose of effecting the reincorporation of Anergen California in the State
of Delaware, it is advisable and in the best interests of Anergen California and
its shareholders that Anergen California merge with and into Anergen Delaware
upon the terms and conditions herein provided.
 
     D. The respective Boards of Directors of Anergen Delaware and Anergen
California have approved this Agreement and have directed that this Agreement be
submitted to a vote of their respective sole stockholder and shareholders, and
executed by the undersigned officers.
 
     NOW, THEREFORE, in consideration of the mutual agreements and covenants set
forth herein, Anergen Delaware and Anergen California hereby agree, subject to
the terms and conditions hereinafter set forth, as follows:
 
                                       I.
 
                                     MERGER
 
     1.1  Merger. In accordance with the provisions of this Agreement, the
Delaware General Corporation Law and the California Corporations Code, Anergen
California shall be merged with and into Anergen Delaware (the "Merger"), the
separate existence of Anergen California shall cease and Anergen Delaware shall
survive the Merger and shall continue to be governed by the laws of the State of
Delaware, and Anergen Delaware shall be, and is herein also referred to as, the
"Surviving Corporation," and the name of the Surviving Corporation shall be
Anergen, Inc.
 
                                       A-1
<PAGE>   52
 
     1.2  Filing and Effectiveness. The Merger shall become effective when the
following actions shall have been completed:
 
          (a) This Agreement and the Merger shall have been adopted and approved
     by the shareholders of each Constituent Corporation in accordance with the
     requirements of the Delaware General Corporation Law and the California
     Corporations Code;
 
          (b) All of the conditions precedent to the consummation of the Merger
     specified in this Agreement shall have been satisfied or duly waived by the
     party entitled to satisfaction thereof;
 
          (c) An executed Certificate of Merger or an executed, acknowledged and
     certified counterpart of this Agreement meeting the requirements of the
     Delaware General Corporation Law shall have been filed with the Secretary
     of State of the State of Delaware; and
 
          (d) An executed Certificate of Merger or an executed, acknowledged and
     certified counterpart of this Agreement meeting the requirements of the
     California Corporations Code shall have been filed with the Secretary of
     State of the State of California.
 
     The date and time when the Merger shall become effective, as aforesaid, is
herein called the "Effective Date of the Merger."
 
     1.3  Effect of the Merger. Upon the Effective Date of the Merger, the
separate existence of Anergen California shall cease and Anergen Delaware, as
the Surviving Corporation, (i) shall continue to possess all of its assets,
rights, powers and property as constituted immediately prior to the Effective
Date of the Merger; (ii) shall be subject to all actions previously taken by its
and Anergen California's Boards of Directors; (iii) shall succeed, without other
transfer, to all of the assets, rights, powers and property of Anergen
California in the manner as more fully set forth in Section 259 of the Delaware
General Corporation Law; (iv) shall continue to be subject to all of its debts,
liabilities and obligations as constituted immediately prior to the Effective
Date of the Merger; and (v) shall succeed, without other transfer, to all of the
debts, liabilities and obligations of Anergen California in the same manner as
if Anergen Delaware had itself incurred them, all as more fully provided under
the applicable provisions of the Delaware General Corporation Law and the
California Corporations Code.
 
                                       II
 
                   CHARTER DOCUMENTS, DIRECTORS AND OFFICERS
 
     2.1  Certificate of Incorporation. The Certificate of Incorporation of
Anergen Delaware as in effect immediately prior to the Effective Date of the
Merger, a copy of which is attached hereto as Appendix A, shall continue in full
force and effect as the Certificate of Incorporation of the Surviving
Corporation until duly amended in accordance with the provisions thereof and
applicable law.
 
     2.2  Bylaws. The Bylaws of Anergen Delaware as in effect immediately prior
to the Effective Date of the Merger shall continue in full force and effect as
the Bylaws of the Surviving Corporation until duly amended in accordance with
the provisions thereof and applicable law.
 
     2.3  Directors and Officers. The directors and officers of Anergen
California immediately prior to the Effective Date of the Merger shall be the
directors and officers of the Surviving Corporation until their respective
successors shall have been duly elected and qualified or until as otherwise
provided by law, or the Certificate of Incorporation of the Surviving
Corporation or the Bylaws of the Surviving Corporation.
 
                                       A-2
<PAGE>   53
 
                                      III.
 
                         MANNER OF CONVERSION OF STOCK
 
     3.1  Anergen California Common Stock. Upon the Effective Date of the
Merger, each share of Anergen California Common Stock, no par value, issued and
outstanding immediately prior thereto shall, by virtue of the Merger and without
any action by the Constituent Corporations, the holder of such shares or any
other person, be changed and converted into and exchanged for one fully paid and
nonassessable share of Common Stock, $.001 par value, of the Surviving
Corporation.
 
     3.2  Anergen California Options and Stock Purchase Rights. Upon the
Effective Date of the Merger, the Surviving Corporation shall assume and
continue the stock option plans (including without limitation the 1988 Stock
Option Plan, the 1996 Stock Plan and the 1995 Director Option Plan) and all
other employee benefit plans (including without limitation the 1991 Employee
Stock Purchase Plan and the 1992 Consultant Stock Plan) of Anergen California.
Each outstanding and unexercised option or other right to purchase a security
convertible into Anergen California Common Stock shall become an option or right
to purchase or a security convertible into the Surviving Corporation's Common
Stock on the basis of one share of the Surviving Corporation's Common Stock for
each share of Anergen California Common Stock issuable pursuant to any such
option, stock purchase right or convertible security, on the same terms and
conditions and at an exercise price per share equal to the exercise price
applicable to any such Anergen California option, stock purchase right or
convertible security at the Effective Date of the Merger. There are no options,
purchase rights for or securities convertible into Preferred Stock of Anergen
California.
 
     A number of shares of the Surviving Corporation's Common Stock shall be
reserved for issuance upon the exercise of options, stock purchase rights or
convertible securities equal to the number of shares of Anergen California
Common Stock so reserved immediately prior to the Effective Date of the Merger.
 
     3.3  Anergen Delaware Common Stock. Upon the Effective Date of the Merger,
each share of Common Stock, $.001 par value, of Anergen Delaware issued and
outstanding immediately prior thereto shall, by virtue of the Merger and without
any action by Anergen Delaware, the holder of such shares or any other person,
be canceled and returned to the status of authorized but unissued shares.
 
     3.4  Certificates. After the Effective Date of the Merger, each outstanding
certificate theretofore representing shares of Anergen California Common Stock
shall be deemed for all purposes to represent the same number of whole shares of
the Surviving Corporation's Common Stock.
 
                                      IV.
 
                                    GENERAL
 
     4.1  Covenants of Anergen Delaware. Anergen Delaware covenants and agrees
that it will, on or before the Effective Date of the Merger:
 
          (a) Qualify to do business as a foreign corporation in the State of
     California and in connection therewith irrevocably appoint an agent for
     service of process as required under the provisions of Section 2105 of the
     California Corporations Code;
 
          (b) File any and all documents with the California Franchise Tax Board
     necessary for the assumption by Anergen Delaware of all of the franchise
     tax liabilities of Anergen California; and
 
          (c) Take such other actions as may be required by the California
     Corporations Code.
 
     4.2  Further Assurances. From time to time, as and when required by Anergen
Delaware or by its successors or assigns, there shall be executed and delivered
on behalf of Anergen California such deeds and other instruments, and there
shall be taken or caused to be taken by Anergen Delaware and Anergen California
such further and other actions, as shall be appropriate or necessary in order to
vest or perfect in or conform of record or otherwise by Anergen Delaware the
title to and possession of all the property, interests, assets, rights,
privileges, immunities, powers, franchises and authority of Anergen California
and otherwise to
 
                                       A-3
<PAGE>   54
 
carry out the purposes of this Agreement, and the officers and directors of
Anergen Delaware are fully authorized in the name and on behalf of Anergen
California or otherwise to take any and all such action and to execute and
deliver any and all such deeds and other instruments.
 
     4.3  Abandonment. At any time before the filing of this Agreement with the
Secretary of State of the State of Delaware, this Agreement may be terminated
and the Merger may be abandoned for any reason whatsoever by the Board of
Directors of either Anergen California or Anergen Delaware, or both,
notwithstanding the approval of this Agreement by the shareholders of Anergen
California or by the sole stockholder of Anergen Delaware, or by both.
 
     4.4  Amendment. The Boards of Directors of the Constituent Corporations may
amend this Agreement at any time prior to the filing of this Agreement (or
certificate in lieu thereof) with the Secretaries of State of the States of
California and Delaware, provided that an amendment made subsequent to the
adoption of this Agreement by the shareholders of either Constituent Corporation
shall not: (i) alter or change the amount or kind of shares, securities, cash,
property and/or rights to be received in exchange for or on conversion of all or
any of the shares of any class or series thereof of such Constituent
Corporation, (ii) alter or change any term of the Certificate of Incorporation
of the Surviving Corporation to be effected by the Merger, or (iii) alter or
change any of the terms and conditions of this Agreement if such alteration or
change would adversely affect the holders of any class of shares or series
thereof of such Constituent Corporation.
 
     4.5  Registered Office. The registered office of the Surviving Corporation
in the State of Delaware is located at Corporation Trust Center, 1209 Orange
Street, in the City of Wilmington, Delaware 19801, County of New Castle, and The
Corporation Trust Company is the registered agent of the Surviving Corporation
at such address.
 
     4.6  Agreement. Executed copies of this Agreement will be on file at the
principal place of business of the Surviving Corporation at 301 Penobscot Drive,
Redwood City, CA 94063 and copies thereof will be furnished to any shareholder
of either Constituent Corporation, upon request and without cost.
 
     4.7  Governing Law. This Agreement shall in all respects be construed,
interpreted and enforced in accordance with and governed by the laws of the
State of Delaware and, so far as applicable, the merger provisions of the
California Corporations Code.
 
     4.8  Counterparts. In order to facilitate the filing and recording of this
Agreement, the same may be executed in any number of counterparts, each of which
shall be deemed to be an original and all of which together shall constitute one
and the same instrument.
 
                                       A-4
<PAGE>   55
 
     IN WITNESS WHEREOF, this Agreement, having first been approved by
resolutions of the Boards of Directors of Anergen Delaware and Anergen
California, is hereby executed on behalf of each of such two corporations and
attested by their respective officers thereunto duly authorized.
 
                                          ANERGEN, INC.
                                          a Delaware corporation
 
                                          By:
                                            ------------------------------------
                                            Barry M. Sherman, M.D., President
 
ATTEST:
 
- ---------------------------------------------------------
David V. Smith,
Chief Financial Officer
 
                                          ANERGEN, INC.
                                          a Delaware corporation
 
                                          By:
                                            ------------------------------------
                                            Barry M. Sherman, M.D., President
 
ATTEST:
 
- ---------------------------------------------------------
David V. Smith,
Chief Financial Officer
 
                                       A-5
<PAGE>   56
 
                                 ANERGEN, INC.
                            (CALIFORNIA CORPORATION)
 
                             OFFICERS' CERTIFICATE
 
Barry M. Sherman, M.D. and David V. Smith certify that:
 
     1. They are the President and the Chief Financial Officer, respectively, of
Anergen, Inc., a corporation organized under the laws of the State of
California.
 
     2. The corporation has authorized two classes of stock, designated "Common
Stock" and "Preferred Stock". There are authorized 40,000,000 shares of Common
Stock and 10,000,000 shares of Preferred Stock, of which 1,157,894 shares are
designated as Series A-1 Preferred Stock, 740,740 shares are designated as
Series A-2 Preferred Stock, 3,002,648 shares are designated as Series B
Preferred Stock and 15,000 shares are designated as Series C Preferred Stock.
 
     3. There were                shares of Common Stock and no shares of
Preferred Stock outstanding as of the record date (the "Record Date") of the
shareholders' meeting at which the Agreement and Plan of Merger attached hereto
(the "Merger Agreement") was approved. All shares of Common Stock outstanding
were entitled to vote on the merger.
 
     4. The principal terms of the Merger Agreement were approved by the Board
of Directors and by the vote of a number of shares of each class of stock which
equaled or exceeded the vote required.
 
     5. The percentage vote required was more than 50% of the votes entitled to
be cast by holders of Common Stock outstanding as of the Record Date, voting as
a single class.
 
     6. Barry M. Sherman, M.D. and David V. Smith further declare under penalty
of perjury under the laws of the State of California that each has read the
foregoing certificate and knows the contents thereof and that the same is true
of their own knowledge.
 
     Executed in Redwood City, California on             , 1998.
 
                                          --------------------------------------
                                          Barry M. Sherman, M.D., President
 
                                          --------------------------------------
                                          David V. Smith, Chief Financial
                                          Officer
 
                                       A-6
<PAGE>   57
 
                                 ANERGEN, INC.
                            (SURVIVING CORPORATION)
 
                             OFFICERS' CERTIFICATE
 
     Barry M. Sherman, M.D. and David V. Smith certify that:
 
     1. They are the President and Chief Financial Officer, respectively, of
Anergen, Inc., a corporation organized under the laws of the State of Delaware.
 
     2. The corporation has authorized two classes of stock, designated "Common
Stock" and "Preferred Stock". There are authorized 60,000,000 shares of Common
Stock and 10,000,000 shares of Preferred Stock. The Preferred Stock is
undesignated as to series, rights, preferences or restrictions.
 
     3. There were 100 shares of Common Stock outstanding and entitled to vote
on the Agreement and Plan of Merger attached hereto (the "Merger Agreement").
There were no shares of Preferred Stock outstanding.
 
     4. The principal terms of the Merger Agreement were approved by the Board
of Directors and by the vote of a number of shares of each class of stock which
equaled or exceeded the vote required.
 
     5. The percentage vote required was more than 50% of the votes entitled to
be cast by holders of outstanding shares of Common Stock.
 
     6. Barry M. Sherman, M.D. and David V. Smith further declare under penalty
of perjury under the laws of the State of Delaware that each has read the
foregoing certificate and knows the contents thereof and that the same is true
of their own knowledge.
 
     Executed in Redwood City, California on             , 1998.
 
                                          --------------------------------------
                                          Barry M. Sherman, M.D., President
 
                                          --------------------------------------
                                          David V. Smith, Chief Financial
                                          Officer
 
                                       A-7
<PAGE>   58
 
                                   APPENDIX A
 
                CERTIFICATE OF INCORPORATION OF ANERGEN DELAWARE
 
                                       A-8
<PAGE>   59
 
                                   EXHIBIT B
 
                          CERTIFICATE OF INCORPORATION
                                       OF
                                 ANERGEN, INC.
 
                                   ARTICLE I
 
     The name of this corporation is Anergen, Inc. (the "Corporation").
 
                                   ARTICLE II
 
     The address of the Corporation's registered office in the State of Delaware
is Corporation Trust Center, 1209 Orange Street, in the City of Wilmington,
County of New Castle, zip code 19801. The name of its registered agent at such
address is The Corporation Trust Company.
 
                                  ARTICLE III
 
     The purpose of the Corporation is to engage in any lawful act or activity
for which corporations may be organized under the General Corporation Law of
Delaware.
 
                                   ARTICLE IV
 
     The Corporation is authorized to issue two classes of stock to be
designated respectively Common Stock and Preferred Stock. The total number of
shares of all classes of stock which the Corporation has authority to issue is
Seventy Million (70,000,000), consisting of Sixty Million (60,000,000) shares of
Common Stock, $0.001 par value (the "Common Stock"), and Ten Million
(10,000,000) shares of Preferred Stock, $0.001 par value (the "Preferred
Stock").
 
     The shares of Preferred Stock may be issued from time to time in one or
more series pursuant to a resolution or resolutions providing for such issue
duly adopted by the Board of Directors. The Board of Directors of the
Corporation is expressly authorized, by filing a certificate pursuant to the
applicable law of the State of Delaware, to: (i) establish from time to time the
number of shares to be included in each such series; (ii) fix the rights,
preferences, restrictions and designations of the shares of each such series,
including but not limited to the fixing or alteration of the dividend rights,
dividend rate, conversion rights, conversion rate, voting rights, rights and
terms of redemption (including sinking fund provisions), redemption price or
prices, voting rights and liquidation preferences of any series of Preferred
Stock for which no shares have been issued and are outstanding; (iii) increase
the number of shares of any series at any time; and (iv) decrease the number of
shares of any series prior or subsequent to the issue of shares of that series,
but not below the number of shares of such series then outstanding. In case the
number of shares of any series shall be so decreased, the shares constituting
such decrease shall resume the status which they had prior to the adoption of
the resolution originally fixing the number of shares of such series.
 
                                   ARTICLE V
 
     The name and mailing address of the incorporator are as follows:
 
       Anna Itoi
        Wilson Sonsini Goodrich & Rosati
        650 Page Mill Road
        Palo Alto, CA 94304-1050
 
                                   ARTICLE VI
 
     The Corporation is to have perpetual existence.
 
                                       B-1
<PAGE>   60
 
                                  ARTICLE VII
 
     The election of directors need not be by written ballot unless a
stockholder demands election by written ballot at a meeting of stockholders and
before voting begins or unless the Bylaws of the Corporation shall so provide.
 
                                  ARTICLE VIII
 
     The number of directors which constitute the whole Board of Directors of
the Corporation shall be designated in the Bylaws of the Corporation.
 
                                   ARTICLE IX
 
     In furtherance and not in limitation of the powers conferred by the laws of
the State of Delaware, the Board of Directors is expressly authorized to adopt,
alter, amend or repeal the Bylaws of the Corporation.
 
                                   ARTICLE X
 
     To the fullest extent permitted by the Delaware General Corporation Law as
the same exists or may hereafter be amended, no director of the Corporation
shall be personally liable to the Corporation or its stockholders for monetary
damages for breach of fiduciary duty as a director.
 
     Neither any amendment nor repeal of this Article, nor the adoption of any
provision of this Certificate of Incorporation inconsistent with this Article,
shall eliminate or reduce the effect of this Article in respect of any matter
occurring, or any cause of action, suit or claim that, but for this Article,
would accrue or arise, prior to such amendment, repeal or adoption of an
inconsistent provision.
 
                                   ARTICLE XI
 
     At the election of directors of the Corporation, each holder of stock of
any class or series shall be entitled to one vote for each share held. No
stockholder will be permitted to cumulate votes at any election of directors.
 
                                  ARTICLE XII
 
     Meetings of stockholders may be held within or without the State of
Delaware, as the Bylaws may provide. The books of the Corporation may be kept
(subject to any provision contained in the laws of the State of Delaware)
outside of the State of Delaware at such place or places as may be designated
from time to time by the Board of Directors or in the Bylaws of the Corporation.
 
                                  ARTICLE XIII
 
     The Corporation reserves the right to amend, alter, change or repeal any
provision contained in this Certificate of Incorporation, in the manner now or
hereafter prescribed by the laws of the State of Delaware, and all rights
conferred herein are granted subject to this reservation.
 
     The undersigned incorporator hereby acknowledges that the foregoing
Certificate of Incorporation is her act and deed and that the facts stated
herein are true.
 
Dated:        , 1998
 
                                          --------------------------------------
                                          Anna Itoi
 
                                       B-2
<PAGE>   61
 
                                   EXHIBIT C
 
                                     BYLAWS
                                       OF
                                 ANERGEN, INC.
<PAGE>   62
 
                               TABLE OF CONTENTS
 
<TABLE>
<CAPTION>
                                                                       PAGE
                                                                       ----
<S>      <C>                                                           <C>
ARTICLE I -- CORPORATE OFFICES.......................................   C-1
  1.1    REGISTERED OFFICE...........................................   C-1
  1.2    OTHER OFFICES...............................................   C-1
 
ARTICLE II -- MEETINGS OF STOCKHOLDERS...............................   C-1
  2.1    PLACE OF MEETINGS...........................................   C-1
  2.2    ANNUAL MEETING..............................................   C-1
  2.3    SPECIAL MEETING.............................................   C-1
  2.4    NOTICE OF STOCKHOLDERS' MEETINGS............................   C-1
  2.5    MANNER OF GIVING NOTICE; AFFIDAVIT OF NOTICE................   C-2
  2.6    QUORUM......................................................   C-2
  2.7    ADJOURNED MEETING; NOTICE...................................   C-2
  2.8    VOTING......................................................   C-2
  2.9    VALIDATION OF MEETING; WAIVER OF NOTICE.....................   C-3
         STOCKHOLDER ACTION BY WRITTEN CONSENT WITHOUT A MEETING.....
 2.10                                                                   C-3
         RECORD DATE FOR STOCKHOLDER NOTICE; VOTING..................
 2.11                                                                   C-3
         PROXIES.....................................................
 2.12                                                                   C-3
         INSPECTORS OF ELECTION......................................
 2.13                                                                   C-3
         LIST OF STOCKHOLDERS ENTITLED TO VOTE.......................
 2.14                                                                   C-4
 
ARTICLE III -- DIRECTORS.............................................   C-4
  3.1    POWERS......................................................   C-4
  3.2    NUMBER OF DIRECTORS.........................................   C-4
  3.3    ELECTION, QUALIFICATION AND TERM OF OFFICE OF DIRECTORS.....   C-4
  3.4    RESIGNATION AND VACANCIES...................................   C-5
  3.5    PLACE OF MEETINGS; MEETINGS BY TELEPHONE....................   C-5
  3.6    FIRST MEETINGS..............................................   C-5
  3.7    REGULAR MEETINGS............................................   C-6
  3.8    SPECIAL MEETINGS; NOTICE....................................   C-6
  3.9    QUORUM......................................................   C-6
         WAIVER OF NOTICE............................................
 3.10                                                                   C-6
         ADJOURNMENT.................................................
 3.11                                                                   C-6
         NOTICE OF ADJOURNMENT.......................................
 3.12                                                                   C-6
         BOARD ACTION BY WRITTEN CONSENT WITHOUT A MEETING...........
 3.13                                                                   C-7
         FEES AND COMPENSATION OF DIRECTORS..........................
 3.14                                                                   C-7
         APPROVAL OF LOANS TO OFFICERS...............................
 3.15                                                                   C-7
         REMOVAL OF DIRECTORS........................................
 3.16                                                                   C-7
 
ARTICLE IV -- COMMITTEES.............................................   C-7
  4.1    COMMITTEES OF DIRECTORS.....................................   C-7
  4.2    COMMITTEE MINUTES...........................................   C-8
  4.3    MEETINGS AND ACTION OF COMMITTEES...........................   C-8
</TABLE>
 
                                        i
<PAGE>   63
 
<TABLE>
<CAPTION>
                                                                       PAGE
                                                                       ----
<S>      <C>                                                           <C>
ARTICLE V -- OFFICERS................................................   C-8
  5.1    OFFICERS....................................................   C-8
  5.2    ELECTION OF OFFICERS........................................   C-8
  5.3    SUBORDINATE OFFICERS........................................   C-8
  5.4    REMOVAL AND RESIGNATION OF OFFICERS.........................   C-8
  5.5    VACANCIES IN OFFICES........................................   C-9
  5.6    CHAIRMAN OF THE BOARD.......................................   C-9
  5.7    CHIEF EXECUTIVE OFFICER.....................................   C-9
  5.8    PRESIDENT...................................................   C-9
  5.9    CHIEF OPERATING OFFICER.....................................   C-9
         CORPORATE VICE PRESIDENTS...................................
 5.10                                                                   C-9
         SECRETARY...................................................
 5.11                                                                   C-9
         CHIEF FINANCIAL OFFICER.....................................
 5.12                                                                  C-10
         TREASURER...................................................
 5.13                                                                  C-10
         ADMINISTRATIVE VICE PRESIDENTS..............................
 5.14                                                                  C-10
         AUTHORITY AND DUTIES OF OFFICERS............................
 5.15                                                                  C-10
 
ARTICLE VI -- INDEMNITY..............................................  C-11
  6.1    INDEMNIFICATION OF DIRECTORS AND OFFICERS...................  C-11
  6.2    INDEMNIFICATION OF OTHERS...................................  C-11
  6.3    PAYMENT OF EXPENSES IN ADVANCE..............................  C-11
  6.4    INDEMNITY NOT EXCLUSIVE.....................................  C-11
  6.5    INSURANCE INDEMNIFICATION...................................  C-12
 
ARTICLE VII -- RECORDS AND REPORTS...................................  C-12
  7.1    MAINTENANCE AND INSPECTION OF RECORDS.......................  C-12
  7.2    MAINTENANCE AND INSPECTION OF BYLAWS........................  C-12
  7.3    MAINTENANCE AND INSPECTION OF OTHER CORPORATE RECORDS.......  C-12
  7.4    INSPECTION BY DIRECTORS.....................................  C-13
  7.5    REPRESENTATION OF SHARES OF OTHER CORPORATIONS..............  C-13
 
ARTICLE VIII -- GENERAL MATTERS......................................  C-13
  8.1    RECORD DATE FOR PURPOSES OTHER THAN NOTICE AND VOTING.......  C-13
  8.2    CHECKS......................................................  C-13
  8.3    EXECUTION OF CORPORATE CONTRACTS AND INSTRUMENTS............  C-14
  8.4    STOCK CERTIFICATES; PARTLY PAID SHARES......................  C-14
  8.5    SPECIAL DESIGNATION ON CERTIFICATES.........................  C-14
  8.6    LOST CERTIFICATES...........................................  C-14
  8.7    CONSTRUCTION; DEFINITIONS...................................  C-15
  8.8    DIVIDENDS...................................................  C-15
  8.9    FISCAL YEAR.................................................  C-15
         TRANSFER OF STOCK...........................................
 8.10                                                                  C-15
         STOCK TRANSFER AGREEMENTS...................................
 8.11                                                                  C-15
         REGISTERED STOCKHOLDERS.....................................
 8.12                                                                  C-15
 
ARTICLE IX -- AMENDMENTS.............................................  C-15
 
ARTICLE X -- DISSOLUTION.............................................  C-16
</TABLE>
 
                                       ii
<PAGE>   64
 
<TABLE>
<CAPTION>
                                                                       PAGE
                                                                       ----
<S>      <C>                                                           <C>
ARTICLE XI -- CUSTODIAN..............................................  C-16
         APPOINTMENT OF A CUSTODIAN IN CERTAIN CASES.................
 11.1                                                                  C-16
         DUTIES OF CUSTODIAN.........................................
 11.2                                                                  C-16
</TABLE>
 
                                       iii
<PAGE>   65
 
                                     BYLAWS
                                       OF
                                 ANERGEN, INC.
 
                                   ARTICLE I
 
                               CORPORATE OFFICES
 
     1.1  Registered Office
 
     The registered office of the corporation shall be in the city of
Wilmington, County of New Castle, State of Delaware.
 
     1.2  Other Offices
 
     The board of directors may at any time establish other offices at any place
or places where the corporation is qualified to do business.
 
                                   ARTICLE II
 
                            MEETINGS OF STOCKHOLDERS
 
     2.1  Place of Meetings
 
     Meetings of stockholders shall be held at any place, within or outside the
State of Delaware, designated by the board of directors. In the absence of any
such designation, stockholders' meetings shall be held at the principal
executive office of the corporation.
 
     2.2  Annual Meeting
 
     The annual meeting of stockholders shall be held each year on a date and at
a time designated by the board of directors. At the meeting, directors shall be
elected and any other proper business may be transacted.
 
     2.3  Special Meeting
 
     A special meeting of the stockholders may be called at any time by the
board of directors, the chairman of the board, the chief executive officer, the
president or by one or more stockholders holding shares in the aggregate
entitled to cast not less than ten percent (10%) of the votes at that meeting.
 
     If a special meeting is called by any person or persons other than the
board of directors, then the request shall be in writing, specifying the time of
such meeting and the general nature of the business proposed to be transacted,
and shall be delivered personally or sent by registered mail or by telegraphic
or other facsimile transmission to the chairman of the board, the chief
executive officer, the president, the chief operating officer, any corporate
vice president or the secretary of the corporation. The officer receiving the
request shall cause notice to be promptly given to the stockholders entitled to
vote, in accordance with the provisions of Sections 2.4 and 2.5 of these bylaws,
that a meeting will be held at the time requested by the person or persons
calling the meeting, so long as that time is not less than thirty-five (35) nor
more than sixty (60) days after the receipt of the request. If the notice is not
given within twenty (20) days after receipt of the request, then the person or
persons requesting the meeting may give the notice. Nothing contained in this
paragraph of this Section 2.3 shall be construed as limiting, fixing or
affecting the time when a meeting of stockholders called by action of the board
of directors may be held.
 
     2.4  Notice of Stockholders' Meetings
 
     All notices of meetings with stockholders shall be in writing and shall be
sent or otherwise given in accordance with Section 2.5 of these bylaws not less
than ten (10) nor more than sixty (60) days before the date of the meeting to
each stockholder entitled to vote at such meeting. The notice shall specify the
place, date, and hour of the meeting, and (i) in the case of a special meeting,
the general nature of the business to be transacted (no business other than that
specified in the notice may be transacted) or (ii) in the case of the
 
                                       C-1
<PAGE>   66
 
annual meeting, those matters which the board of directors, at the time of
giving the notice, intends to present for action by the stockholders (but any
proper matter may be presented at the meeting for such action). The notice of
any meeting at which directors are to be elected shall include the name of any
nominee or nominees who, at the time of the notice, management intends to
present for election.
 
     2.5  Manner of Giving Notice; Affidavit of Notice
 
     Written notice of any meeting of stockholders, if mailed, is given when
deposited in the United States mail, postage prepaid, directed to the
stockholder at his address as it appears on the records of the corporation. An
affidavit of the secretary or an assistant secretary of the transfer agent of
the corporation that the notice has been given shall, in the absence of fraud,
be prima facie evidence of the facts stated therein.
 
     2.6  Quorum
 
     The holders of a majority of the shares entitled to vote, present in person
or represented by proxy, shall constitute a quorum for the transaction of
business at all meetings of stockholders, except as otherwise provided by
statute or by the certificate of incorporation. The stockholders present at a
duly called or held meeting at which a quorum is present may continue to do
business until adjournment, notwithstanding the withdrawal of enough
stockholders to leave less than a quorum, if any action taken (other than
adjournment) is approved by at least a majority of the shares required to
constitute a quorum.
 
     When a quorum is present at any meeting, the affirmative vote of holders of
a the majority of the stock having voting power present in person or represented
by proxy shall decide any question brought before such meeting, unless the
question is one upon which, by express provision of the laws of the State of
Delaware or of the certificate of incorporation or these bylaws, a different
vote is required, in which case such express provision shall govern and control
the decision of the question.
 
     2.7  Adjourned Meeting; Notice
 
     Any stockholders' meeting, annual or special, whether or not a quorum is
present, may be adjourned from time to time by the vote of the majority of the
shares represented at that meeting, either in person or by proxy, but in the
absence of a quorum, no other business may be transacted at that meeting, except
as provided in Section 2.6 of these bylaws.
 
     When any meeting of stockholders, either annual or special, is adjourned to
another time or place, unless these bylaws otherwise require, notice need not be
given of the adjourned meeting if the time and place thereof are announced at
the meeting at which the adjournment is taken. At the adjourned meeting the
corporation may transact any business that might have been transacted at the
original meeting. If the adjournment is for more than thirty (30) days, or if
after the adjournment a new record date is fixed for the adjourned meeting, a
notice of the adjourned meeting shall be given to each stockholder of record
entitled to vote at the adjourned meeting in accordance with the provisions of
Sections 2.4 and 2.5 of these bylaws.
 
     2.8  Voting
 
     The stockholders entitled to vote at any meeting of stockholders shall be
determined in accordance with the provisions of Section 2.11 of these bylaws,
subject to the provisions of Sections 217 and 218 of the General Corporation Law
of Delaware (relating to voting rights of fiduciaries, pledgers and joint owners
of stock and to voting trusts and other voting agreements).
 
     Except as provided in the last paragraph of this Section 2.8, or as may be
otherwise provided in the certificate of incorporation, each stockholder shall
be entitled to one vote for each share of capital stock held by such
stockholder.
 
     On any matter other than the election of directors, any stockholder may
vote part of the shares in favor of the proposal and refrain from voting the
remaining shares or vote them against the proposal, but, if the stockholder
fails to specify the number of shares which the stockholder is voting
affirmatively, it will be conclusively presumed that the stockholder's approving
vote is with respect to all shares which the stockholder is entitled to vote.
 
                                       C-2
<PAGE>   67
 
     If a quorum is present, the affirmative vote of the majority of the shares
represented and voting at a duly-held meeting (which shares voting affirmatively
also constitute at least a majority of the required quorum) shall be the act of
the stockholders, unless the vote of a greater number, or voting by classes, is
required by law or by the certificate of incorporation.
 
     2.9  Validation of Meeting; Waiver of Notice
 
     Whenever notice is required to be given under any provision of the General
Corporation Law of Delaware or of the certificate of incorporation or these
bylaws, a written waiver thereof, signed by the person entitled to notice,
whether before or after the time stated therein, shall be deemed equivalent to
notice. Attendance of a person at a meeting shall constitute a waiver of notice
of such meeting, except when the person attends a meeting for the express
purpose of objecting, at the beginning of the meeting, to the transaction of any
business because the meeting is not lawfully called or convened. Neither the
business to be transacted at, nor the purpose of, any regular or special meeting
of the stockholders need be specified in any written waiver of notice unless so
required by the certificate of incorporation or these bylaws.
 
     2.10  Stockholder Action by Written Consent Without a Meeting
 
     The stockholders of the corporation may not take action by written consent
without a meeting but must take any such actions at a duly called annual or
special meeting.
 
     2.11  Record Date for Stockholder Notice; Voting
 
     For purposes of determining the stockholders entitled to notice of any
meeting or to vote thereat, the board of directors may fix, in advance, a record
date, which shall not be more than sixty (60) days nor less than ten (10) days
before the date of any such meeting and in such event only stockholders of
record on the date so fixed are entitled to notice and to vote, notwithstanding
any transfer of any shares on the books of the corporation after the record
date.
 
     If the board of directors does not so fix a record date, the record date
for determining stockholders entitled to notice of or to vote at a meeting of
stockholders shall be at the close of business on the business day next
preceding the day on which notice is given or, if notice is waived, at the close
of business on the business day next preceding the day on which the meeting is
held.
 
     A determination of stockholders of record entitled to notice of or to vote
at a meeting of stockholders shall apply to any adjournment of the meeting
unless the board of directors fixes a new record date for the adjourned meeting,
but the board of directors shall fix a new record date if the meeting is
adjourned for more than thirty (30) days from the date set for the original
meeting.
 
     The record date for any other purpose shall be as provided in Section 8.1
of these bylaws.
 
     2.12  Proxies
 
     Each stockholder entitled to vote at a meeting of stockholders may
authorize another person or persons to act for him by a written proxy, signed by
the stockholder and filed with the secretary of the corporation, but no such
proxy shall be voted or acted upon after three (3) years from its date, unless
the proxy provides for a longer period. A proxy shall be deemed signed if the
stockholder's name is placed on the proxy (whether by manual signature,
typewriting, telegraphic transmission or otherwise) by the stockholder or the
stockholder's attorney-in-fact. The revocability of a proxy that states on its
face that it is irrevocable shall be governed by the provisions of Section
212(e) of the General Corporation Law of Delaware.
 
     2.13  Inspectors of Election
 
     Before any meeting of stockholders, the board of directors may appoint one
or more inspectors to act at the meeting and make a written report thereof. The
board of directors may designate one or more persons as alternate inspectors to
replace any inspector who fails to act. If no inspector or alternate is able to
act at a meeting of stockholders, the person presiding at the meeting shall
appoint one or more inspectors to act at the meeting.
 
                                       C-3
<PAGE>   68
 
     Such inspectors shall:
 
          (a) ascertain the number of shares outstanding and the voting power of
     each;
 
          (b) determine the shares represented at a meeting and the validity of
     proxies and ballots;
 
          (c) count all votes and ballots;
 
          (d) determine and retain for a reasonable period a record of the
     disposition of any challenges made to any determination by the inspectors;
     and
 
          (e) certify their determination of the number of shares represented at
     the meeting, and their count of all votes and ballots.
 
     The inspectors may appoint or retain other persons or entities to assist
the inspectors in the performance of the inspectors' duties.
 
     2.14  List of Stockholders Entitled to Vote
 
     The officer who has charge of the stock ledger of a corporation shall
prepare and make, at least ten (10) days before every meeting of stockholders, a
complete list of the stockholders entitled to vote at the meeting, arranged in
alphabetical order, and showing the address of each stockholder and the number
of shares registered in the name of each stockholder. Such list shall be open to
the examination of any stockholder, for any purpose germane to the meeting,
during ordinary business hours, for a period of at least ten (10) days prior to
the meeting, either at a place within the city where the meeting is to be held,
which place shall be specified in the notice of the meeting, or, if not so
specified, at the place where the meeting is to be held. The list shall also be
produced and kept at the time and place of the meeting during the whole time
thereof, and may be inspected by any stockholder who is present.
 
                                  ARTICLE III
 
                                   DIRECTORS
 
     3.1  Powers
 
     Subject to the provisions of the General Corporation Law of Delaware and
any limitations in the certificate of incorporation or these bylaws relating to
action required to be approved by the stockholders or by the outstanding shares,
the business and affairs of the corporation shall be managed and all corporate
powers shall be exercised by or under the direction of the board of directors.
 
     3.2  Number of Directors
 
     The authorized number of directors shall be eight (8). This number may be
changed by a duly adopted amendment to the certificate of incorporation or by an
amendment to this bylaw adopted by the vote or written consent of the holders of
a majority of the stock issued and outstanding and entitled to vote or by
resolution of a majority of the board of directors.
 
     No reduction of the authorized number of directors shall have the effect of
removing any director before that director's term of office expires.
 
     3.3  Election, Qualification and Term of Office of Directors
 
     Except as provided in Section 3.4 of these bylaws, directors shall be
elected at each annual meeting of stockholders to hold office until the next
annual meeting. Directors need not be stockholders unless so required by the
certificate of incorporation or these bylaws, wherein other qualifications for
directors may be prescribed. Each director, including a director elected to fill
a vacancy, shall hold office until his successor is elected and qualified or
until his earlier resignation or removal.
 
     Elections of directors need not be by written ballot.
 
                                       C-4
<PAGE>   69
 
     3.4  Resignation and Vacancies
 
     Any director may resign effective on giving written notice to the chairman
of the board, the president, the secretary or the board of directors, unless the
notice specifies a later time for that resignation to become effective. If the
resignation of a director is effective at a future time, the board of directors
may elect a successor to take office when the resignation becomes effective.
 
     Vacancies in the board of directors may be filled by a majority of the
remaining directors, even if less than a quorum, or by a sole remaining
director; provided, a vacancy created by the removal of a director by the vote
of the stockholders or by court order may be filled only by the affirmative vote
of a majority of the shares represented and voting at a duly held meeting at
which a quorum is present (which shares voting affirmatively also constitute a
majority of the required quorum). Each director so elected shall hold office
until the next annual meeting of the stockholders and until a successor has been
elected and qualified.
 
     A vacancy or vacancies in the board of directors shall be deemed to exist
in the event of the death, resignation or removal of any director, or if the
board of directors by resolution declares vacant the office of a director who
has been declared of unsound mind by an order of court or convicted of a felony,
or if the authorized number of directors is increased, or if the stockholders
fail, at any meeting of stockholders at which any director of directors are
elected, to elect the number of directors to be elected at that meeting.
 
     The stockholders may elect a director or directors at any time to fill any
vacancy or vacancies not filled by the directors.
 
     If at any time, by reason of death or resignation or other cause, the
corporation should have no directors in office, then any officer or any
stockholder or an executor, administrator, trustee or guardian of a stockholder,
or other fiduciary entrusted with like responsibility for the person or estate
of a stockholder, may call a special meeting of stockholders in accordance with
the provisions of the certificate of incorporation or these bylaws, or may apply
to the Court of Chancery for a decree summarily ordering an election as provided
in Section 211 of the General Corporation Law of Delaware.
 
     If, at the time of filling any vacancy or any newly created directorship,
the directors then in office constitute less than a majority of the whole board
(as constituted immediately prior to any such increase), then the Court of
Chancery may, upon application of any stockholder or stockholders holding at
least ten (10) percent of the total number of the shares at the time outstanding
having the right to vote for such directors, summarily order an election to be
held to fill any such vacancies or newly created directorships, or to replace
the directors chosen by the directors then in office as aforesaid, which
election shall be governed by the provisions of Section 211 of the General
Corporation Law of Delaware as far as applicable.
 
     3.5  Place of Meetings; Meetings by Telephone
 
     Regular meetings of the board of directors may be held at any place within
or outside the State of Delaware that has been designated from time to time by
resolution of the board. In the absence of such a designation, regular meetings
shall be held at the principal executive office of the corporation. Special
meetings of the board may be held at any place within or outside the State of
Delaware that has been designated in the notice of the meeting or, if not stated
in the notice or if there is no notice, at the principal executive office of the
corporation.
 
     Any meeting of the board, regular or special, may be held by conference
telephone or similar communication equipment, so long as all directors
participating in the meeting can hear one another; and all such directors shall
be deemed to be present in person at the meeting.
 
     3.6  First Meetings
 
     The first meeting of each newly elected board of directors shall be held at
such time and place as shall be fixed by the vote of the stockholders at the
annual meeting and no notice of such meeting shall be necessary to the newly
elected directors in order legally to constitute the meeting, provided a quorum
shall be present. In the event of the failure of the stockholders to fix the
time or place of such first meeting of the newly elected board of directors, or
in the event such meeting is not held at the time and place so fixed by the
stockholders,
 
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the meeting may be held at such time and place as shall be specified in a notice
given as hereinafter provided for special meetings of the board of directors, or
as shall be specified in a written waiver signed by all of the directors.
 
     3.7  Regular Meetings
 
     Regular meetings of the board of directors may be held without notice at
such time and at such place as shall from time to time be determined by the
board.
 
     3.8  Special Meetings; Notice
 
     Special meetings of the board of directors for any purpose or purposes may
be called at any time by the chairman of the board, the chief executive officer,
the president, the chief operating officer or any two (2) directors.
 
     Notice of the date, time and place of special meetings shall be delivered
personally, by telephone, facsimile, telegram, electronic mail or other
comparable communication equipment to each director or sent by first-class mail,
charges prepaid, addressed to each director at that director's address as it is
shown on the records of the corporation. If the notice is mailed, it shall be
deposited in the United States mail at least four (4) days before the time of
the holding of the meeting. If the notice is delivered personally or by
telephone, facsimile, telegram, electronic mail or other comparable
communication equipment, it shall be delivered at least twelve (12) hours before
the time of the holding of the meeting. Any notice given personally or by
telephone, facsimile, telegram, electronic mail or other comparable
communication equipment may be communicated either to the director or to a
person at the office of the director who the person giving the notice has reason
to believe will promptly communicate it to the director. The notice need not
specify the purpose or the place of the meeting, if the meeting is to be held at
the principal executive office of the corporation.
 
     3.9  Quorum
 
     A majority of the authorized number of directors shall constitute a quorum
for the transaction of business, except to adjourn as provided in Section 3.11
of these bylaws. Every act or decision done or made by a majority of the
directors present at a duly held meeting at which a quorum is present shall be
regarded as the act of the board of directors, subject to the provisions of the
certificate of incorporation and applicable law.
 
     A meeting at which a quorum is initially present may continue to transact
business notwithstanding the withdrawal of directors, if any action taken is
approved by at least a majority of the required quorum for that meeting.
 
     3.10  Waiver of Notice
 
     Whenever notice is required to be given under any provision of the General
Corporation Law of Delaware or of the certificate of incorporation or these
bylaws, a written waiver thereof, signed by the person entitled to notice,
whether before or after the time stated therein, shall be deemed equivalent to
notice. Attendance of a person at a meeting shall constitute a waiver of notice
of such meeting, except when the person attends a meeting for the express
purpose of objecting, at the beginning of the meeting, to the transaction of any
business because the meeting is not lawfully called or convened. Neither the
business to be transacted at, nor the purpose of, any regular or special meeting
of the directors, or members of a committee of directors, need be specified in
any written waiver of notice unless so required by the certificate of
incorporation or these bylaws.
 
     3.11  Adjournment
 
     A majority of the directors present, whether or not constituting a quorum,
may adjourn any meeting to another time and place.
 
     3.12  Notice of Adjournment
 
     Notice of the time and place of holding an adjourned meeting need not be
given, unless the meeting is adjourned for more than twenty-four (24) hours, in
which case notice of the time and place shall be given
 
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<PAGE>   71
 
before the time of the adjourned meeting, in the manner specified in Section 3.8
of these bylaws, to the directors who were not present at the time of the
adjournment.
 
     3.13  Board Action by Written Consent Without a Meeting
 
     Unless otherwise restricted by the certificate of incorporation or these
bylaws, any action required or permitted to be taken at any meeting of the board
of directors, or of any committee thereof, may be taken without a meeting if all
members of the board or committee, as the case may be, shall individually or
collectively consent thereto in writing. Such action by written consent shall
have the same force and effect as a unanimous vote of the board of directors.
Such written consent and any counterparts thereof shall be filed with the
minutes of the proceedings of the board.
 
     3.14  Fees and Compensation of Directors
 
     Directors and members of committees may receive such compensation, if any,
for their services and such reimbursement of expenses as may be fixed or
determined by resolution of the board of directors. This Section 3.14 shall not
be construed to preclude any director from serving the corporation in any other
capacity as an officer, agent, employee or otherwise and receiving compensation
for those services.
 
     3.15  Approval of Loans to Officers
 
     The corporation may lend money to, or guarantee any obligation of, or
otherwise assist any officer or other employee of the corporation or of its
subsidiary, including any officer or employee who is a director of the
corporation or its subsidiary, whenever, in the judgment of the directors, such
loan, guaranty or assistance may reasonably be expected to benefit the
corporation. The loan, guaranty or other assistance may be with or without
interest and may be unsecured, or secured in such manner as the board of
directors shall approve, including, without limitation, a pledge of shares of
stock of the corporation. Nothing in this section contained shall be deemed to
deny, limit or restrict the powers of guaranty or warranty of the corporation at
common law or under any statute.
 
     3.16  Removal of Directors
 
     Unless otherwise restricted by statute, by the certificate of incorporation
or by these bylaws, any director or the entire board of directors may be
removed, with or without cause, by the holders of a majority of the shares then
entitled to vote at an election of directors.
 
     No reduction of the authorized number of directors shall have the effect of
removing any director prior to the expiration of such director's term of office.
 
                                   ARTICLE IV
 
                                   COMMITTEES
 
     4.1  Committees of Directors
 
     The board of directors may, by resolution adopted by a majority of the
authorized number of directors, designate one (1) or more committees, each
consisting of two (2) or more directors, to serve at the pleasure of the board.
The board may designate one (1) or more directors as alternate members of any
committee, who may replace any absent member at any meeting of the committee.
The appointment of members or alternate members of a committee requires the vote
of a majority of the authorized number of directors. Any committee, to the
extent provided in the resolution of the board, shall have all the authority of
the board, except with respect to (i) amend the certificate of incorporation
(except that a committee may, to the extent authorized in the resolution or
resolutions providing for the issuance of shares of stock adopted by the board
of directors as provided in Section 151(a) of the General Corporation Law of
Delaware, fix any of the preferences or rights of such shares relating to
dividends, redemption, dissolution, any distribution of assets of the
corporation or the conversion into, or the exchange of such shares for, shares
of any other class or classes or any other series of the same or any other class
or classes of stock of the corporation), (ii) adopt an agreement of merger or
consolidation under Sections 251 or 252 of the General Corporation Law of
Delaware,
 
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(iii) recommend to the stockholders the sale, lease or exchange of all or
substantially all of the corporation's property and assets, (iv) recommend to
the stockholders a dissolution of the corporation or a revocation of a
dissolution, or (v) adopt a certificate of ownership and merger pursuant to
Section 253 of the General Corporation Law of Delaware.
 
     4.2  Committee Minutes
 
     Each committee shall keep regular minutes of its meetings and report the
same to the board of directors when required.
 
     4.3  Meetings and Action of Committees
 
     Meetings and actions of committees shall be governed by, and held and taken
in accordance with, the provisions of Article III of these bylaws, Section 3.5
(place of meetings and meetings by telephone), Section 3.7 (regular meetings),
Section 3.8 (special meetings and notice), Section 3.9 (quorum), Section 3.10
(waiver of notice), Section 3.11 (adjournment), Section 3.12 (notice of
adjournment), and Section 3.13 (action without a meeting), with such changes in
the context of those bylaws as are necessary to substitute the committee and its
members for the board of directors and its members; provided, however, that the
time of regular meetings of committees may also be called by resolution of the
board of directors and that notice of special meetings of committees shall also
be given to all alternate members, who shall have the right to attend all
meetings of the committee. The board of directors may adopt rules for the
government of any committee not inconsistent with the provisions of these
bylaws.
 
                                   ARTICLE V
 
                                    OFFICERS
 
     5.1  Officers
 
     The officers of the corporation shall be a president, a secretary, and a
chief financial officer. The corporation may also have, at the discretion of the
board of directors, a chairman of the board, a chief executive officer, a chief
operating officer, a treasurer, one or more corporate vice presidents, one or
more assistant secretaries, one or more assistant treasurers, and any such other
officers as may be appointed in accordance with the provisions of Section 5.3 of
these bylaws. Any number of offices may be held by the same person.
 
     In addition to the officers of the corporation described above, there may
also be such administrative vice presidents of the corporation as may be
designated and appointed from time to time by the chief executive officer of the
corporation in accordance with the provisions of Section 5.14 of these bylaws.
 
     5.2  Election of Officers
 
     The officers of the corporation, except such officers as may be appointed
in accordance with the provisions of Sections 5.3 or 5.5 of these bylaws, shall
be chosen by the board of directors, subject to the rights, if any, of an
officer under any contract of employment.
 
     5.3  Subordinate Officers
 
     The board of directors may appoint, or empower the president to appoint,
such other officers and agents as the business of the corporation may require,
each of whom shall hold office for such period, have such authority, and perform
such duties as are provided in these bylaws or as the board of directors may
from time to time determine.
 
     5.4  Removal and Resignation of Officers
 
     Subject to the rights, if any, of an officer under any contract of
employment, any officer may be removed, either with or without cause, by an
affirmative vote of the majority of the board of directors at any regular or
special meeting of the board or, except in the case of an officer chosen by the
board of directors, by any officer upon whom such power of removal may be
conferred by the board of directors.
 
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<PAGE>   73
 
     Any officer may resign at any time by giving written notice to the
corporation. Any resignation shall take effect at the date of the receipt of
that notice or at any later time specified in that notice; and, unless otherwise
specified in that notice, the acceptance of the resignation shall not be
necessary to make it effective. Any resignation is without prejudice to the
rights, if any, of the corporation under any contract to which the officer is a
party.
 
     5.5  Vacancies in Offices
 
     A vacancy in any office because of death, resignation, removal,
disqualification or any other cause shall be filled in the manner prescribed in
these bylaws for regular appointments to that office.
 
     5.6  Chairman of the Board
 
     The chairman of the board, if such an officer be elected, shall, if
present, preside at meetings of the board of directors and exercise and perform
such other powers and duties as may from time to time be assigned to him by the
board of directors or as may be prescribed by these bylaws. If there is no chief
executive officer, then the chairman of the board shall also have the powers and
duties prescribed in Section 5.7 of these bylaws.
 
     5.7  Chief Executive Officer
 
     Subject to such supervisory powers, if any, as may be given by the board of
directors to the chairman of the board, if there be such an officer, the chief
executive officer of the corporation shall, subject to the control of the board
of directors, have general supervision, direction, and control of the business
and the officers of the corporation. He shall preside at all meetings of the
stockholders and, in the absence of the chairman of the board, or if there be
none, at all meetings of the board of directors. He shall have the general
powers and duties of management usually vested in the office of president of a
corporation and shall have such other powers and duties as may be prescribed by
the board of directors or these bylaws.
 
     5.8  President
 
     The president of the corporation shall have such powers and perform such
duties as prescribed by the board of directors or these bylaws. In the absence
or disability of the chief executive officer or if there be no such officer,
then the president shall have the same powers and be subject to the same
restrictions set forth in Section 5.7.
 
     5.9  Chief Operating Officer
 
     The chief operating officer shall have such powers and perform such duties
as prescribed by the board of directors or these bylaws. In the absence or
disability of the chief executive officer, if there be such an officer, the
president and the chairman of the board, the chief operating officer shall
perform the duties of chief executive officer and president, and when so acting
shall have all the powers, and be subject to all the restrictions set forth in
Section 5.7.
 
     5.10  Corporate Vice Presidents
 
     In the absence or disability of the chief executive officer, if there be
such an officer, the president, the chairman of the board and the chief
operating officer, if there be such an officer, the corporate vice presidents,
if any, in order of their rank as fixed by the board of directors or, if not
ranked, a corporate vice president designated by the board of directors, shall
perform all the duties of the chief executive officer and president and when so
acting shall have all the powers of, and be subject to all the restrictions
upon, the chief executive officer and president. The corporate vice presidents
shall also have such other powers and perform such other duties as from time to
time may be prescribed for them respectively by the board of directors or these
bylaws.
 
     5.11  Secretary
 
     The secretary shall keep or cause to be kept, at the principal executive
office of the corporation, or such other place as the board of directors may
direct, a book of minutes of all meetings and actions of directors, committees
of directors, and stockholders, with the time and place of holding, whether
regular or special (and, if special, how authorized and the notice given), the
names of those present at directors' meetings or
 
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<PAGE>   74
 
committee meetings, the number of shares present or represented at stockholders'
meetings, and the proceedings thereof.
 
     The secretary shall keep, or cause to be kept, at the principal executive
office of the corporation or at the office of the corporation's transfer agent
or registrar, as determined by resolution of the board of directors, a share
register, or a duplicate share register, showing the names of all stockholders
and their addresses, the number and classes of shares held by each, the number
and date of certificates evidencing such shares, and the number and date of
cancellation of every certificate surrendered for cancellation.
 
     The secretary shall give, or cause to be given, notice of all meetings of
the stockholders and of the board of directors required by these bylaws or by
law to be given, and he shall keep the seal of the corporation, if one be
adopted, in safe custody and shall have such other powers and perform such other
duties as may be prescribed by the board of directors or by these bylaws.
 
     5.12  Chief Financial Officer
 
     The chief financial officer shall keep and maintain, or cause to be kept
and maintained, adequate and correct books and records of accounts of the
properties and business transactions of the corporation, including accounts of
its assets, liabilities, receipts, disbursements, gains, losses, capital,
retained earnings and shares. The books of account shall at all reasonable times
be open to inspection by any director.
 
     The chief financial officer shall deposit all money and other valuables in
the name and to the credit of the corporation with such depositories as may be
designated by the board of directors. He shall disburse the funds of the
corporation as may be ordered by the board of directors, shall render to the
president and directors, whenever they request it, an account of all of his
transactions as chief financial officer and of the financial condition of the
corporation, and shall have such other powers and perform such other duties as
may be prescribed by the board of directors or these bylaws.
 
     5.13  Treasurer
 
     In the absence or disability of the chief financial officer, the treasurer
shall perform all the duties of the chief financial officer and when so acting
shall have all the powers of, and be subject to all the restrictions upon, the
chief financial officer. The treasurer shall have such other powers and perform
such other duties as from time to time may be prescribed respectively by the
board of directors or these bylaws.
 
     5.14  Administrative Vice Presidents
 
     In addition to the corporate vice presidents of the corporation as provided
in Section 5.10 of these bylaws and such subordinate officers as may be
appointed in accordance with Section 5.3 of these bylaws, there may also be such
administrative vice presidents of the corporation as may be designated and
appointed from time to time by the chief executive officer of the corporation.
Administrative vice presidents shall perform such duties and have such powers as
from time to time may be determined by the chief executive officer or the board
of directors in order to assist the officers of the corporation in the
furtherance of their duties. In the performance of such duties and the exercise
of such powers, however, such administrative vice presidents shall have limited
authority to act on behalf of the corporation as the board of directors shall
establish, including but not limited to limitations on the dollar amount and on
the scope of the agreements or commitments that may be made by such
administrative vice presidents on behalf of the corporation, which limitations
may not be exceeded by such individuals or altered by the chief executive
officer without further approval by the board of directors.
 
     5.15  Authority and Duties of Officers
 
     In addition to the foregoing authority and duties, all officers of the
corporation shall respectively have such authority and perform such duties in
the management of the business of the corporation as may be designated from time
to time by the board of directors or the stockholders.
 
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<PAGE>   75
 
                                   ARTICLE VI
 
                                   INDEMNITY
 
     6.1  Indemnification of Directors and Officers
 
     The corporation shall, to the maximum extent and in the manner permitted by
the General Corporation Law of Delaware as the same now exists or may hereafter
be amended, indemnify any person against expenses (including attorneys' fees),
judgments, fines, and amounts paid in settlement actually and reasonably
incurred in connection with any threatened, pending or completed action, suit,
or proceeding in which such person was or is a party or is threatened to be made
a party by reason of the fact that such person is or was a director or officer
of the corporation. For purposes of this Section 6.1, a "director" or "officer"
of the corporation shall mean any person (i) who is or was a director or officer
of the corporation, (ii) who is or was serving at the request of the corporation
as a director or officer of another corporation, partnership, joint venture,
trust or other enterprise, or (iii) who was a director or officer of a
corporation which was a predecessor corporation of the corporation or of another
enterprise at the request of such predecessor corporation.
 
     The corporation shall be required to indemnify a director or officer in
connection with an action, suit, or proceeding (or part thereof) initiated by
such director or officer only if the initiation of such action, suit, or
proceeding (or part thereof) by the director or officer was authorized by the
board of Directors of the corporation.
 
     Any repeal or modification of the foregoing provisions of this Article
shall not adversely affect any right or protection hereunder of any person in
respect of any act or omission occurring prior to the time of such repeal or
modification.
 
     6.2  Indemnification of Others
 
     The corporation shall have the power, to the maximum extent and in the
manner permitted by the General Corporation Law of Delaware as the same now
exists or may hereafter be amended, to indemnify each of its employees and
agents (other than directors and officers) against expenses (including
attorneys' fees), judgments, fines, and amounts paid in settlement actually and
reasonably incurred in connection with any threatened, pending or completed
action, suit, or proceeding, in which such person was or is a party or is
threatened to be made a party by reason of the fact that such person is or was
an employee or agent of the corporation. For purposes of this Section 6.2, an
"employee" or "agent" of the corporation (other than a director or officer)
shall mean any person (i) who is or was an employee or agent of the corporation,
(ii) who is or was serving at the request of the corporation as an employee or
agent of another corporation, partnership, joint venture, trust or other
enterprise, or (iii) who was an employee or agent of a corporation which was a
predecessor corporation of the corporation or of another enterprise at the
request of such predecessor corporation.
 
     6.3  Payment of Expenses in Advance
 
     The corporation shall pay the expenses (including attorney's fees) incurred
by a director or officer of the corporation entitled to indemnification
hereunder in defending any action, suit or proceeding referred to in this
Section 6.1 in advance of its final disposition; provided, however, that payment
of expenses incurred by a director or officer of the corporation in advance of
the final disposition of such action, suit or proceeding shall be made only upon
receipt of an undertaking by the director or officer to repay all amounts
advanced if it should ultimately be determined that the director or officer is
not entitled to be indemnified under this Section 6.1 or otherwise.
 
     6.4  Indemnity not Exclusive
 
     The rights conferred on any person by this Article shall not be exclusive
of any other rights which such person may have or hereafter acquire under any
statute, provision of the corporation's Certificate of Incorporation, these
bylaws, agreement, vote of the stockholders or disinterested directors or
otherwise.
 
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<PAGE>   76
 
     6.5  Insurance Indemnification
 
     The corporation may purchase and maintain insurance on behalf of any person
who is or was a director, officer, employee or agent of the corporation, or is
or was serving at the request of the corporation as a director, officer,
employee or agent of another corporation, partnership, joint venture, trust or
other enterprise against any liability asserted against him or her and incurred
by him or her in any such capacity, or arising out of his or her status as such,
whether or not the corporation would have the power to indemnify him or her
against such liability under the provisions of the General Corporation Law of
Delaware.
 
                                  ARTICLE VII
 
                              RECORDS AND REPORTS
 
     7.1  Maintenance and Inspection of Records
 
     The corporation shall, either at its principal executive office or at such
place or places as designated by the board of directors, keep a record of its
stockholders listing their names and addresses and the number and class of
shares held by each stockholder.
 
     Any stockholder of record, in person or by attorney or other agent, shall,
upon written demand under oath stating the purpose thereof, have the right
during the usual hours for business to inspect for any proper purpose the
corporation's stock ledger and a list of its stockholders and to make copies or
extracts therefrom. A proper purpose shall mean a purpose reasonably related to
such person's interest as a stockholder. In every instance where an attorney or
other agent is the person who seeks the right to inspection, the demand under
oath shall be accompanied by a power of attorney or such other writing that
authorizes the attorney or other agent to so act on behalf of the stockholder.
The demand under oath shall be directed to the corporation at its registered
office in Delaware or at its principal place of business.
 
     The officer who has charge of the stock ledger of a corporation shall
prepare and make, at least ten (10) days before every meeting of stockholders, a
complete list of the stockholders entitled to vote at the meeting, arranged in
alphabetical order, and showing the address of each stockholder and the number
of shares registered in the name of each stockholder. Such list shall be open to
the examination of any stockholder, for any purpose germane to the meeting,
during ordinary business hours, for a period of at least ten (10) days prior to
the meeting, either at a place within the city where the meeting is to be held,
which place shall be specified in the notice of the meeting, or, if not so
specified, at the place where the meeting is to be held. The list shall also be
produced and kept at the time and place of the meeting during the whole time
thereof, and may be inspected by any stockholder who is present.
 
     The record of stockholders shall also be open to inspection on the written
demand of any stockholder or holder of a voting trust certificate, at any time
during usual business hours, for a purpose reasonably related to the holder's
interests as a stockholder or as the holder of a voting trust certificate.
 
     Any inspection and copying under this Section 7.1 may be made in person or
by an agent or attorney of the stockholder or holder of a voting trust
certificate making the demand.
 
     7.2  Maintenance and Inspection of Bylaws
 
     The corporation shall keep at its principal executive office, or if its
principal executive office is not in the State of California, at its principal
business office in such state, the original or a copy of these bylaws as amended
to date, which bylaws shall be subject to inspection by the stockholders at all
reasonable times during office hours. If the principal executive office of the
corporation is outside the State of California and the corporation has no
principal business office in such state, the secretary shall, upon the written
request of any stockholder, furnish to that stockholder a copy of these bylaws
as amended to date.
 
     7.3  Maintenance and Inspection of Other Corporate Records
 
     The accounting books and records, and the minutes of proceedings of the
stockholders and the board of directors and any committee or committees of the
board of directors, shall be kept at such place or places
 
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<PAGE>   77
 
designated by the board of directors or, in absence of such designation, at the
principal executive office of the corporation. The minutes shall be kept in
written form and the accounting books and records shall be kept either in
written form or in any other form capable of being converted into written form.
 
     The minutes and accounting books and records shall be open to inspection
upon the written demand of any stockholder or holder of a voting trust
certificate, at any reasonable time during usual business hours, for a purpose
reasonably related to the holder's interests as a stockholder or as the holder
of a voting trust certificate. The inspection may be made in person or by an
agent or attorney, and shall include the right to copy and make extracts. Such
rights of inspection shall extend to the records of each subsidiary corporation
of the corporation.
 
     7.4  Inspection by Directors
 
     Every director shall have the absolute right at any reasonable time to
inspect all books, records and documents of every kind and the physical
properties of the corporation and each of its subsidiary corporations. Such
inspection by a director may be made in person or by an agent or attorney, and
the right of inspection includes the right to copy and make extracts of
documents.
 
     The corporation shall also, on the written request of any stockholder, mail
to the stockholder a copy of the last annual, semi-annual or quarterly income
statement which it has prepared, and a balance sheet as of the end of that
period.
 
     The quarterly income statements and balance sheets referred to in this
section shall be accompanied by the report, if any, of any independent
accountants engaged by the corporation or the certificate of an authorized
officer of the corporation that the financial statements were prepared without
audit from the books and records of the corporation.
 
     7.5  Representation of Shares of Other Corporations
 
     The chairman of the board, the chief executive officer, the president, the
chief operating officer, any corporate vice president, the treasurer, the
secretary or the chief financial officer of this corporation, or any other
person authorized by the board of directors or the president or a vice
president, is authorized to vote, represent, and exercise on behalf of this
corporation all rights incident to any and all shares of any other corporation
or corporations standing in the name of this corporation. The authority granted
herein may be exercised either by such person directly or by any other person
authorized to do so by proxy or power of attorney duly executed by such person
having the authority.
 
                                  ARTICLE VIII
 
                                GENERAL MATTERS
 
     8.1  Record Date for Purposes Other Than Notice and Voting
 
     For purposes of determining the stockholders entitled to receive payment of
any dividend or other distribution or allotment of any rights or the
stockholders entitled to exercise any rights in respect of any other lawful
action, the board of directors may fix, in advance, a record date, which shall
not be more than sixty (60) days before any such action. In that case, only
stockholders of record at the close of business on the date so fixed are
entitled to receive the dividend, distribution or allotment of rights, or to
exercise such rights, as the case may be, notwithstanding any transfer of any
shares on the books of the corporation after the record date so fixed, except as
otherwise provided by law.
 
     If the board of directors does not so fix a record date, then the record
date for determining stockholders for any such purpose shall be at the close of
business on the day on which the board adopts the applicable resolution, or the
sixtieth (60th) day before the date of that action, whichever is later.
 
     8.2  Checks
 
     From time to time, the board of directors shall determine by resolution
which person or persons may sign or endorse all checks, drafts, other orders for
payment of money, notes or other evidences of indebtedness that
 
                                      C-13
<PAGE>   78
 
are issued in the name of or payable to the corporation, and only the persons so
authorized shall sign or endorse those instruments.
 
     8.3  Execution of Corporate Contracts and Instruments
 
     The board of directors, except as otherwise provided in these bylaws, may
authorize any officer or officers, or agent or agents, to enter into any
contract or execute any instrument in the name of and on behalf of the
corporation; such authority may be general or confined to specific instances.
Unless so authorized or ratified by the board of directors or within the agency
power of an officer, no officer, agent or employee shall have any power or
authority to bind the corporation by any contract or engagement or to pledge its
credit or to render it liable for any purpose or for any amount.
 
     8.4  Stock Certificates; Partly Paid Shares
 
     The shares of a corporation shall be represented by certificates, provided
that the board of directors of the corporation may provide by resolution or
resolutions that some or all of any or all classes or series of its stock shall
be uncertificated shares. Any such resolution shall not apply to shares
represented by a certificate until such certificate is surrendered to the
corporation. Notwithstanding the adoption of such a resolution by the board of
directors, every holder of stock represented by certificates and upon request
every holder of uncertificated shares shall be entitled to have a certificate
signed by, or in the name of the corporation by the chairman or vice-chairman of
the board of directors, or the president or vice-president, and by the chief
financial officer or an assistant treasurer, or the secretary or an assistant
secretary of such corporation representing the number of shares registered in
certificate form. Any or all of the signatures on the certificate may be a
facsimile. In case any officer, transfer agent or registrar who has signed or
whose facsimile signature has been placed upon a certificate has ceased to be
such officer, transfer agent or registrar before such certificate is issued, it
may be issued by the corporation with the same effect as if he were such
officer, transfer agent or registrar at the date of issue.
 
     The corporation may issue the whole or any part of its shares as partly
paid and subject to call for the remainder of the consideration to be paid
therefor. Upon the face or back of each stock certificate issued to represent
any such partly paid shares, upon the books and records of the corporation in
the case of uncertificated partly paid shares, the total amount of the
consideration to be paid therefor and the amount paid thereon shall be stated.
Upon the declaration of any dividend on fully paid shares, the corporation shall
declare a dividend upon partly paid shares of the same class, but only upon the
basis of the percentage of the consideration actually paid thereon.
 
     8.5  Special Designation on Certificates
 
     If the corporation is authorized to issue more than one class of stock or
more than one series of any class, then the powers, the designations, the
preferences, and the relative, participating, optional or other special rights
of each class of stock or series thereof and the qualifications, limitations or
restrictions of such preferences and/or rights shall be set forth in full or
summarized on the face or back of the certificate that the corporation shall
issue to represent such class or series of stock; provided, however, that,
except as otherwise provided in Section 202 of the General Corporation Law of
Delaware, in lieu of the foregoing requirements there may be set forth on the
face or back of the certificate that the corporation shall issue to represent
such class or series of stock a statement that the corporation will furnish
without charge to each stockholder who so requests the powers, the designations,
the preferences, and the relative, participating, optional or other special
rights of each class of stock or series thereof and the qualifications,
limitations or restrictions of such preferences and/or rights.
 
     8.6  Lost Certificates
 
     Except as provided in this Section 8.6, no new certificates for shares
shall be issued to replace a previously issued certificate unless the latter is
surrendered to the corporation and canceled at the same time. The corporation
may issue a new certificate of stock or uncertificated shares in the place of
any certificate theretofore issued by it, alleged to have been lost, stolen or
destroyed, and the corporation may require the owner of the lost, stolen or
destroyed certificate, or his legal representative, to give the corporation a
bond
 
                                      C-14
<PAGE>   79
 
sufficient to indemnify it against any claim that may be made against it on
account of the alleged loss, theft or destruction of any such certificate or the
issuance of such new certificate or uncertificated shares.
 
     8.7  Construction; Definitions
 
     Unless the context requires otherwise, the general provisions, rules of
construction, and definitions in the Delaware General Corporation Law shall
govern the construction of these bylaws. Without limiting the generality of this
provision, the singular number includes the plural, the plural number includes
the singular, and the term "person' includes both a corporation and a natural
person.
 
     8.8  Dividends
 
     The directors of the corporation, subject to any restrictions contained in
the certificate of incorporation, may declare and pay dividends upon the shares
of its capital stock pursuant to the General Corporation Law of Delaware.
Dividends may be paid in cash, in property, or in shares of the corporation's
capital stock.
 
     The directors of the corporation may set apart out of any of the funds of
the corporation available for dividends a reserve or reserves for any proper
purpose and may abolish any such reserve. Such purposes shall include but not be
limited to equalizing dividends, repairing or maintaining any property of the
corporation, and meeting contingencies.
 
     8.9  Fiscal Year
 
     The fiscal year of the corporation shall be fixed by resolution of the
board of directors and may be changed by the board of directors.
 
     8.10  Transfer of Stock
 
     Upon surrender to the corporation or the transfer agent of the corporation
of a certificate for shares duly endorsed or accompanied by proper evidence of
succession, assignation or authority to transfer, it shall be the duty of the
corporation to issue a new certificate to the person entitled thereto, cancel
the old certificate, and record the transaction in its books.
 
     8.11  Stock Transfer Agreements
 
     The corporation shall have power to enter into and perform any agreement
with any number of stockholders of any one or more classes of stock of the
corporation to restrict the transfer of shares of stock of the corporation of
any one or more classes owned by such stockholders in any manner not prohibited
by the General Corporation Law of Delaware.
 
     8.12  Registered Stockholders
 
     The corporation shall be entitled to recognize the exclusive right of a
person registered on its books as the owner of shares to receive dividends and
to vote as such owner, shall be entitled to hold liable for calls and
assessments the person registered on its books as the owner of shares, and shall
not be bound to recognize any equitable or other claim to or interest in such
share or shares on the part of another person, whether or not it shall have
express or other notice thereof, except as otherwise provided by the laws of
Delaware.
 
                                   ARTICLE IX
 
                                   AMENDMENTS
 
     The original or other bylaws of the corporation may be adopted, amended or
repealed by the stockholders entitled to vote; provided, however, that the
corporation may, in its certificate of incorporation, confer the power to adopt,
amend or repeal bylaws upon the directors. The fact that such power has been so
conferred upon the directors shall not divest the stockholders of the power, nor
limit their power to adopt, amend or repeal bylaws.
 
                                      C-15
<PAGE>   80
 
                                   ARTICLE X
 
                                  DISSOLUTION
 
     If it should be deemed advisable in the judgment of the board of directors
of the corporation that the corporation should be dissolved, the board, after
the adoption of a resolution to that effect by a majority of the whole board at
any meeting called for that purpose, shall cause notice to be mailed to each
stockholder entitled to vote thereon of the adoption of the resolution and of a
meeting of stockholders to take action upon the resolution.
 
     At the meeting a vote shall be taken for and against the proposed
dissolution. If a majority of the outstanding stock of the corporation entitled
to vote thereon votes for the proposed dissolution, then a certificate stating
that the dissolution has been authorized in accordance with the provisions of
Section 275 of the General Corporation Law of Delaware and setting forth the
names and residences of the directors and officers shall be executed,
acknowledged, and filed and shall become effective in accordance with Section
103 of the General Corporation Law of Delaware. Upon such certificate's becoming
effective in accordance with Section 103 of the General Corporation Law of
Delaware, the corporation shall be dissolved.
 
     Whenever all the stockholders entitled to vote on a dissolution consent in
writing, either in person or by duly authorized attorney, to a dissolution, no
meeting of directors or stockholders shall be necessary. The consent shall be
filed and shall become effective in accordance with Section 103 of the General
Corporation Law of Delaware. Upon such consent's becoming effective in
accordance with Section 103 of the General Corporation Law of Delaware, the
corporation shall be dissolved. If the consent is signed by an attorney, then
the original power of attorney or a photocopy thereof shall be attached to and
filed with the consent. The consent filed with the Secretary of State shall have
attached to it the affidavit of the secretary or some other officer of the
corporation stating that the consent has been signed by or on behalf of all the
stockholders entitled to vote on a dissolution; in addition, there shall be
attached to the consent a certification by the secretary or some other officer
of the corporation setting forth the names and residences of the directors and
officers of the corporation.
 
                                   ARTICLE XI
 
                                   CUSTODIAN
 
     11.1  Appointment of a Custodian in Certain Cases
 
     The Court of Chancery, upon application of any stockholder, may appoint one
or more persons to be custodians and, if the corporation is insolvent, to be
receivers, of and for the corporation when:
 
          (i) at any meeting held for the election of directors the stockholders
     are so divided that they have failed to elect successors to directors whose
     terms have expired or would have expired upon qualification of their
     successors; or
 
          (ii) the business of the corporation is suffering or is threatened
     with irreparable injury because the directors are so divided respecting the
     management of the affairs of the corporation that the required vote for
     action by the board of directors cannot be obtained and the stockholders
     are unable to terminate this division; or
 
          (iii) the corporation has abandoned its business and has failed within
     a reasonable time to take steps to dissolve, liquidate or distribute its
     assets.
 
     11.2  Duties of Custodian
 
     The custodian shall have all the powers and title of a receiver appointed
under Section 291 of the General Corporation Law of Delaware, but the authority
of the custodian shall be to continue the business of the corporation and not to
liquidate its affairs and distribute its assets, except when the Court of
Chancery otherwise orders and except in cases arising under Sections 226(a)(3)
or 352(a)(2) of the General Corporation Law of Delaware.
 
                                      C-16
<PAGE>   81
 
                       CERTIFICATE OF ADOPTION OF BYLAWS
                                       OF
                                 ANERGEN, INC.
 
                            ADOPTION BY INCORPORATOR
 
     The undersigned person appointed in the Certificate of Incorporation to act
as the Incorporator of ANERGEN, INC. hereby adopts the foregoing bylaws,
comprising 24 pages, as the Bylaws of the corporation.
 
     Executed this                day of                1998.
 
                                          --------------------------------------
                                                 Anna Itoi, Incorporator
 
              CERTIFICATE BY SECRETARY OF ADOPTION BY INCORPORATOR
 
     The undersigned hereby certifies that he is the duly elected, qualified,
and acting Secretary of ANERGEN, INC. and that the foregoing Bylaws, comprising
  pages, were adopted as the Bylaws of the corporation on             , 1998, by
the person appointed in the Certificate of Incorporation to act as the
Incorporator of the corporation.
 
     IN WITNESS WHEREOF, the undersigned has hereunto set his hand and affixed
the corporate seal this                day of                1998.
 
                                          --------------------------------------
                                          Barry M. Sherman, M.D., Secretary
 
                                      C-17
<PAGE>   82
 
                                   EXHIBIT D
 
                                 ANERGEN, INC.
 
                           INDEMNIFICATION AGREEMENT
 
     This INDEMNIFICATION AGREEMENT is made as of the      day of
               , 1998 by and between Anergen, Inc., a Delaware corporation (the
"Corporation" or "Anergen Delaware"), and the individual whose name appears on
the signature page hereof (such individual being referred to herein as the
"Indemnified Representative" and, together with other persons who may execute
similar agreements, as "Indemnified Representatives").
 
     WHEREAS, Anergen, Inc., a California corporation ("Anergen California"),
and the Indemnified Representative entered into an Indemnification Agreement
(the "Original Indemnification Agreement"), pursuant to which Anergen California
agreed under certain conditions to indemnify the Indemnified Representative;
 
     WHEREAS, on             , 1998, Anergen California merged with and into
Anergen Delaware (the "Merger"), following approval of the Merger by the Boards
of Directors of Anergen California and Anergen Delaware, the sole stockholder of
Anergen Delaware and a majority of the shareholders of Anergen California (which
approval also included approval of this amendment and restatement of the
Original Indemnification Agreement);
 
     WHEREAS, the Indemnified Representative currently is and will be in the
future serving in one or more capacities as a director, officer, employee, or
agent of the Corporation or, at the request of the Corporation, as a director,
officer, employee, agent fiduciary, or trustee of, or in a similar capacity for,
another corporation, partnership, joint venture, trust, employee benefit plan,
or other entity, and in so doing is and will be performing a valuable service to
or on behalf of the Corporation;
 
     WHEREAS, the Board of Directors of the Corporation has determined that, in
order to attract and retain qualified individuals, the Corporation will attempt
to maintain, at its sole expense, liability insurance to protect persons serving
the Corporation and its subsidiaries from certain liabilities. Although the
furnishing of such insurance has been a customary and widespread practice among
United States based corporations and other business enterprises, the Corporation
believes that, given current market conditions and trends, such insurance may be
available to it in the future only at higher premiums and with more exclusions.
At the same time, directors, officers, and other persons in service to
corporations or business enterprises are being increasingly subjected to
expensive and time-consuming litigation relating to, among other things, matters
that traditionally would have been brought only against the Corporation or
business enterprise itself;
 
     WHEREAS, the Indemnified Representative is willing to continue to serve and
to undertake additional duties and responsibilities for and on behalf of the
Corporation on the condition that he be indemnified contractually by the
Corporation; and
 
     WHEREAS, as an inducement to the Indemnified Representative to continue to
serve the Corporation, and in consideration for such continued service, the
Corporation has agreed to indemnify the Indemnified Representative upon the
terms set forth herein.
 
     NOW, THEREFORE, in consideration of the promises and mutual covenants
contained herein, and intending to be legally bound hereby, the Corporation and
the Indemnified Representative agree as follows.
 
     1. Agreement to Serve. The Indemnified Representative agrees to serve or
continue to serve for or on behalf of the Corporation in each Official Capacity
(as hereinafter defined) held now or in the future for so long as the
Indemnified Representative is duly elected or appointed or until such time as
the Indemnified Representative tenders a resignation in writing. This Agreement
shall not be deemed an employment contract between the Corporation or any of its
subsidiaries and any Indemnified Representative who is an employee of the
Corporation or any of its subsidiaries. The Indemnified Representative
specifically acknowledges that the Indemnified Representative's employment with
the Corporation or any of its subsidiaries, if any, is at will, and that the
Indemnified Representative may be discharged at any time for any reason, with or
without cause,
 
                                       D-1
<PAGE>   83
 
except as may be otherwise provided in any written employment contract between
the Indemnified Representative and the Corporation or any of its subsidiaries,
other applicable formal severance policies duly adopted by the board of
directors of the Indemnified Representative's employer, or, with respect to
service as a director of the Corporation, by the Corporation's Certificate of
Incorporation, by-laws, and the Delaware General Corporation Law. The foregoing
notwithstanding, this Agreement shall continue in force after the Indemnified
Representative has ceased to serve in any Official Capacity for or on behalf of
the Corporation or any of its subsidiaries.
 
     2. Indemnification.
 
     (a) Except as provided in Section 3 and 5 hereof, the Corporation shall
indemnify the Indemnified Representative against any Liability (as hereinafter
defined) incurred by or assessed against the Indemnified Representative in
connection with any Proceeding (as hereinafter defined) in which the Indemnified
Representative may be involved, as a party or otherwise, by reason of the fact
that the Indemnified Representative is or was serving in any Official Capacity
held now or in the future, including, without limitation, any Liability
resulting from actual or alleged breach or neglect of duty, error, misstatement,
misleading statement, omission, negligence, act giving rise to strict or product
liability, act giving rise to liability for environmental contamination, or
other act or omission, whether occurring prior to or after the date of this
Agreement. As used in this Agreement:
 
          (1) "Liability" means any damage, judgment, amount paid in settlement,
     fine, penalty, punitive damage, or expense of any nature (including
     attorneys' fees and expenses);
 
          (2) "Proceeding" means any threatened, pending, or completed action,
     suit, appeal, arbitration, or other proceeding of any nature, whether
     civil, criminal, administrative, or investigative, whether formal or
     informal, and whether brought by or in the right of the Corporation, a
     class of its security holders, or any other party; and
 
          (3) "Official Capacity" means service to the Corporation as a director
     or officer or, at the request of the Corporation, as a director, officer,
     employee, agent, fiduciary, or trustee of, or in a similar capacity for,
     another corporation, partnership, joint venture, trust, employee benefit
     plan (including a plan qualified under the Employee Retirement Income
     Security Act of 1974), or other entity.
 
     (b) Notwithstanding Section 2(a) hereof, except for a Proceeding brought
pursuant to Section 5(d) of this Agreement, the Corporation shall not indemnify
the Indemnified Representative under this Agreement for any Liability incurred
in a Proceeding initiated by the Indemnified Representative unless the
Proceeding is authorized, either before or after commencement of the Proceeding,
by the majority vote of a quorum of the Board of Directors of the Corporation.
An affirmative defense or counterclaim of an Indemnified Representative shall
not be deemed to constitute a Proceeding initiated by the Indemnified
Representative.
 
     3. Exclusions.
 
     (a) The Corporation shall not be liable under this Agreement to make any
payment in connection with any Liability incurred by the Indemnified
Representative:
 
          (1) to the extent payment for such Liability is made to the
     Indemnified Representative under an insurance policy obtained by the
     Corporation;
 
          (2) to the extent payment is made to the Indemnified Representative
     for such Liability by the Corporation under its Certification of
     Incorporation, by-laws, the Delaware General Corporation Law, or otherwise
     than pursuant to this Agreement;
 
          (3) to the extent such Liability is determined in a final
     determination pursuant to Section 5(d) hereof to be based upon or
     attributable to the Indemnified Representative gaining any personal profit
     to which such Indemnified Representative was not legally entitled;
 
          (4) for any claim by or on behalf of the Corporation for recovery of
     profits resulting from the purchase and sale or sale and purchase by such
     Indemnified Representative of equity securities of the Corporation pursuant
     to Section 16(b) of the Securities Exchange Act of 1934, as amended;
                                       D-2
<PAGE>   84
 
          (5) for which the conduct of the Indemnified Representative has been
     determined in a final determination pursuant to Section 5(d) hereof to
     constitute bad faith or active and deliberate dishonesty, in either such
     case material to the cause of action or claim at issue in the Proceeding,
     or
 
          (6) to the extent such indemnification has been determined in a final
     determination pursuant to Section 5(d) hereof to be unlawful.
 
     (b) Any act, omission, liability, knowledge, or other fact of or relating
to any other person, including any other person who is also an Indemnified
Representative, shall not be imputed to the Indemnified Representative for the
purposes of determining the applicability of any exclusion set forth herein.
 
     (c) The termination of a proceeding by judgment, order, settlement,
conviction, or upon a plea of Nolo Contendere or its equivalent shall not, of
itself, create a presumption that the Indemnified Representative is not entitled
to indemnification under this Agreement.
 
     4. Advancement Of Expenses. The Corporation shall pay any Liability in the
nature of an expense (including attorneys' fees and expenses) incurred in good
faith by the Indemnified Representative in advance of the final disposition of a
Proceeding within thirty (30) days of receipt of a demand for payment by the
Indemnified Representative; provided, however, that the Indemnified
Representative shall repay such amount if it shall ultimately be determined,
pursuant to Section 5(d) hereof, that the Indemnified Representative is not
entitled to be indemnified by the Corporation pursuant to this Agreement. The
financial ability of the Indemnified Representative to repay an advance shall
not be a prerequisite to the making of such advance.
 
     5. Indemnification Procedure.
 
     (a) The Indemnified Representative shall use his best efforts to notify
promptly the Secretary of the Corporation of the commencement of any Proceeding
or the occurrence of any event which might give rise to a Liability under this
Agreement, but the failure to so notify the Corporation shall not relieve the
Corporation of any obligation which it may have to the Indemnified
Representative under this Agreement or otherwise.
 
     (b) The Corporation shall be entitled, upon notice to the Indemnified
Representative, to assume the defense of any Proceeding with counsel reasonably
satisfactory to the Indemnified Representative involved in such Proceeding or,
if there be more than one (1) Indemnified Representatives involved in such
Proceeding, to a majority of the Indemnified Representatives involved in such
Proceeding. If, in accordance with the foregoing, the Corporation defends the
Proceeding, the Corporation shall not be liable for the expenses (including
attorneys' fees and expenses) of the Indemnified Representative incurred in
connection with the defense of such Proceeding subsequent to the required
notice, unless (i) such expenses (including attorneys' fees) have been
authorized by the Corporation or (ii) the Corporation shall not in fact have
employed counsel reasonably satisfactory to such Indemnified Representative, or
to the majority of Indemnified Representatives if more than one (1) is involved,
to assume the defense of such Proceeding. The foregoing notwithstanding, the
Indemnified Representative may elect to retain counsel at the Indemnified
Representative's own cost and expense to participate in the defense of such
Proceeding.
 
     (c) the Corporation shall not be required to obtain the consent of the
Indemnified Representative to the settlement of any Proceeding which the
Corporation has undertaken to defend if the Corporation assumes full and sole
responsibility for such settlement and the settlement grants the Indemnified
Representative a complete and unqualified release in respect of the potential
Liability. The Corporation shall not be liable for any amount paid by an
Indemnified Representative in settlement of any Proceeding that is not defended
by the Corporation, unless the Corporation has consented to such settlement,
which consent shall not be unreasonably withheld.
 
     (d) Except as set forth herein, any dispute concerning the right to
indemnification under this Agreement and any other dispute arising hereunder,
including but not limited to matters of validity, interpretation, application,
and enforcement, shall be determined exclusively by and through final and
binding arbitration in Wilmington, Delaware, each party hereto expressly and
conclusively waiving its, his or her right to proceed to a judicial
determination with respect to such matter; provided, however, that in the event
that a claim for indemnification against liabilities arising under the
Securities Act of 1933 (the "Act") (other than the
 
                                       D-3
<PAGE>   85
 
payment by the Corporation of expenses incurred or paid by a director, officer,
or controlling person of the Corporation in the successful defense of any
action, suit, or proceeding) is asserted by a director, officer, or controlling
person in connection with securities being registered under the Act, the
Corporation will, unless in the opinion of its counsel the matter has been
settled by controlling precedent, submit to a court of competent jurisdiction
the question whether such indemnification by it is against public policy as
expressed in the Act and will be governed by the final adjudication of such
issue. The arbitration shall be conducted in accordance with the commercial
arbitration rules then in effect of the American Arbitration Association before
a panel of three (3) arbitrators, one (1) of whom shall be selected by the
Corporation, the second of whom shall be selected by the Indemnified
Representative, and the third of whom shall be selected by the other two (2)
arbitrators. Each arbitrator selected as provided herein is required to be
serving or to have served as a director or an executive officer of a corporation
whose shares of common stock, during at least one year of such service, were
quoted in the Nasdaq National Market System or listed on the New York Stock
Exchange or the American Stock Exchange. The Corporation shall reimburse the
Indemnified Representative for the expenses (including attorneys' fees) incurred
in prosecuting or defending such arbitration to the full extent of such expenses
if the Indemnified Representative is awarded 50% or more of the monetary value
of his claim or, if not, to the extent such expenses are determined by the
arbitrators to be allocable to the Corporation. It is expressly understood and
agreed by the parties that a party may compel arbitration pursuant to this
Section 5(d) through an action for specific performance and that any award
entered by the arbitrators may be enforced, without further evidence or
proceedings, in any court of competent jurisdiction.
 
     (e) Upon a payment under this Agreement to the Indemnified Representative
with respect to any Liability, the Corporation shall be subjugated to the extent
of such payment to all of the rights of the Indemnified Representative to
recover against any person with respect to such Liability, and the Indemnified
Representative shall execute all documents and instruments required and shall
take such other actions as may be necessary to secure such rights including the
execution of such documents as may be necessary for the Corporation to bring
suit to enforce such rights.
 
     6. Contribution. If the indemnification provided for in this Agreement is
unavailable for any reason to hold harmless an Indemnified Representative in
respect of any Liability or portion thereof the Corporation shall contribute to
such Liability or portion thereof in such proportion as is appropriate to
reflect the relative benefits received by the Corporation and the Indemnified
Representative from the transaction giving rise to the Liability.
 
     7. Partial Indemnification. If the Indemnified Representative is entitled
under any provision of this agreement to indemnification by the Corporation for
some or a portion of expenses incurred in connection with any Proceeding, but
not, however, for all of the total amount thereof, the Corporation shall
nevertheless indemnify the Indemnified Representative for the portion of such
expenses to which the Indemnified Representative is entitled.
 
     8. Non-Exclusivity. The rights granted to the Indemnified Representative
pursuant to this Agreement shall not be deemed exclusive of any other rights to
which the Indemnified Representative may be entitled under statute, the
provisions of any certificate of incorporation, by-laws, or agreement, a vote of
stockholders or directors, or otherwise, both as to action in an Official
Capacity and in any other capacity.
 
     9. Reliance on Provisions. The Indemnified Representative shall be deemed
to be acting in any Official Capacity in reliance upon the rights of
indemnification provided by this Agreement and the indemnification provisions of
the Corporation's by-laws.
 
     10. Severability and Reformation. Any provision of this Agreement which is
determined to be invalid or unenforceable in any jurisdiction or under any
circumstances shall be ineffective only to the extent of such invalidity or
unenforceability and shall be deemed reformed to the extent necessary to conform
to the applicable law of such jurisdiction and still give maximum effect to the
intent of the parties hereto. Any such determination shall not invalidate or
render unenforceable the remaining provisions hereof and shall not invalidate or
render unenforceable such provision in any other jurisdiction or under any other
circumstances.
 
                                       D-4
<PAGE>   86
 
     11. Notices. Any notice, claim, request, or demand required or permitted
hereunder shall be in writing and shall be deemed given if delivered personally
or sent by telegram or by registered or certified mail, first class, postage
prepaid: (i) if to the Corporation to Anergen, Inc., 301 Penobscot Drive,
Redwood City, CA 94063, Attention: Secretary, or (ii) if to any Indemnified
Representative, to the address of such Indemnified Representative listed on the
signature page hereof, or to such other address as any party hereto shall have
specified in a notice duly given in accordance with this Section 10.
 
     11. Amendments: Binding Effect. No amendment, modification, termination, or
cancellation of this Agreement shall be effective as to the Indemnified
Representative unless signed in writing by the Corporation and the Indemnified
Representative. This Agreement shall be binding upon the Corporation and its
successors and assigns and shall inure to the benefit of the Indemnified
Representative's heirs, executors, administrators, and personal representatives.
 
     12. Governing Law. This Agreement shall be governed by and construed in
accordance with the laws of the State of Delaware, without regard to the
conflict of laws provisions thereof.
 
     IN WITNESS WHEREOF, the undersigned have executed this Agreement as of the
day and year first set forth above.
 
                                          ANERGEN, INC.
 
                                          --------------------------------------
(Corporate Seal)
 
Attest:
 
- ---------------------------------------------------------
Secretary
 
INDEMNIFIED REPRESENTATIVE
 
- ---------------------------------------------------------
Witness:
 
- ---------------------------------------------------------
Name
 
- ---------------------------------------------------------
Address
 
                                       D-5
<PAGE>   87
                                                                       Exhibit 1


                                 ANERGEN, INC.

                        1991 EMPLOYEE STOCK PURCHASE PLAN




     The following constitute the provisions of the 1991 Employee Stock Purchase
Plan of Anergen, Inc.

     1.   Purpose. The purpose of the Plan is to provide employees of the 
Company and its Designated Subsidiaries with an opportunity to purchase Common
Stock of the Company through accumulated payroll deductions. It is the intention
of the Company to have the Plan qualify as an "Employee Stock Purchase Plan"
under Section 423 of the Internal Revenue Code of 1986, as amended. The
provisions of the Plan, accordingly, shall be construed so as to extend and
limit participation in a manner consistent with the requirements of that section
of the Code.

     2.   Definitions.

          (a) "Board" shall mean the Board of Directors of the Company.

          (b) "Code" shall mean the Internal Revenue Code of 1986, as amended.

          (c) "Common Stock" shall mean the Common Stock of the Company.

          (d) "Company" shall mean Anergen, Inc., a California corporation.

          (e) "Compensation" shall mean all base straight time gross earnings
plus payments for overtime, shift premiums and commissions, but excluding
incentive compensation, incentive payments, bonuses, awards, and other
compensation.

          (f) "Designated Subsidiaries" shall mean the Subsidiaries which have
been designated by the Board from time to time in its sole discretion as
eligible to participate in the Plan.

          (g) "Employee" shall mean any individual who is a regular employee of
the Company for purposes of tax withholding under the Code. For purposes of the
Plan, the employment relationship shall be treated as continuing intact while
the individual is on sick leave or other leave of absence approved by the
Company. Where the period of leave exceeds 90 days and the individual's right to
reemployment is not guaranteed either by statute or by contract, the employment
relationship will be deemed to have terminated on the 91st day of such leave.

          (h) "Enrollment Date" shall mean the first Trading Day of each
Offering Period.

          (i) "Exercise Date" shall mean the last Trading Day of each Purchase
Period.




<PAGE>   88

          (j)  "Fair Market Value" shall mean, as of any date, the value of
Common Stock determined as follows:

               (1) If the Common Stock is listed on any established stock
exchange or a national market system, including without limitation the National
Market System of the National Association of Securities Dealers, Inc. Automated
Quotation ("NASDAQ") System, its Fair Market Value shall be the closing sales
price for such stock (or the closing bid, if no sales were reported), as quoted
on such exchange (or the exchange with the greatest volume of trading in Common
Stock) or system on the day of such determination, as reported in the Wall
Street Journal or such other source as the Board deems reliable, or;

               (2) If the Common Stock is quoted on the NASDAQ system (but not
on the National Market System thereof) or is regularly quoted by a recognized
securities dealer but selling prices are not reported, its Fair Market Value
shall be the mean between the high and low asked prices for the Common Stock on
the day of such determination, as reported in the Wall Street Journal or such
other source as the Board deems reliable, or; 

               (3) In the absence of an established market for the Common Stock,
the Fair Market Value thereof shall be determined in good faith by the Board.

          (k)  "First Commencement Date" shall mean the date of the final
prospectus for the Company's initial public offering.

          (l) "Offering Period" shall mean the period commencing on the
Enrollment Date and continuing for approximately twenty-four (24) months, except
as provided in paragraph 4.

          (m) "Plan" shall mean this Employee Stock Purchase Plan.

          (n) "Purchase Price" shall mean, with respect to the first Offering
Period, an amount equal to the lower of (i) the price per share received by the
Company in its initial public offering and (ii) the Fair Market Value of a share
of Common Stock on the Exercise Date; and with respect to subsequent Offering
Periods, an amount equal to the lower of (i) 85% of the Fair Market Value of a
share of Common Stock on the Enrollment Date and (ii) 85% of the Fair Market
Value of a share of Common Stock on the Exercise Date.

          (o) "Purchase Period" shall mean the approximately six month period
commencing after one Exercise Date and ending with the next Exercise Date,
except that the first Purchase Period of any Offering Period shall commence on
the Enrollment Date and end with the next Exercise Date.

          (p) "Reserves" shall mean the number of shares of Common Stock covered
by each option under the Plan which have not yet been exercised and the number
of shares of Common Stock which have been authorized for issuance under the Plan
but not yet placed under option.




                                      -2-
<PAGE>   89


          (q) "Subsidiary" shall mean a corporation, domestic or foreign, of
which not less than 50% of the voting shares are held by the Company or a
Subsidiary, whether or not such corporation now exists or is hereafter organized
or acquired by the Company or a Subsidiary.

          (r) "Trading Day" shall mean a day on which national stock exchanges
and the National Association of Securities Dealers Automated Quotation (NASDAQ)
System are open for trading.

     3.   Eligibility.

          (a) Any Employee, as defined in paragraph 2, who has been continuously
employed by the Company for at least three (3) consecutive months and who shall
be employed by the Company on a given Enrollment Date shall be eligible to
participate in the Plan; provided, however, that with respect to the first
Offering Period under the Plan, any Employee employed by the Company on the
Enrollment Date thereof shall be eligible to participate in the Plan.

          (b) Any provisions of the Plan to the contrary notwithstanding, no
Employee shall be granted an option under the Plan (i) if, immediately after the
grant, such Employee (or any other person whose stock would be attributed to
such Employee pursuant to Section 424(d) of the Code) would own stock and/or
hold outstanding options to purchase stock possessing five percent (5%) or more
of the total combined voting power or value of all classes of stock of the
Company or of any subsidiary of the Company, or (ii) which permits his or her
rights to purchase stock under all employee stock purchase plans of the Company
and its subsidiaries to accrue at a rate which exceeds Twenty-Five Thousand
Dollars ($25,000) worth of stock (determined at the fair market value of the
shares at the time such option is granted) for each calendar year in which such
option is outstanding at any time.

     4.   Offering Periods. The Plan shall be implemented by consecutive and
overlapping Offering Periods, with the first Offering Period beginning the First
Commencement Date and continuing unless terminated in accordance with the Plan.
The Board shall have the power to change the duration of Offering Periods with
respect to future offerings without shareholder approval if such change is
announced at least fifteen (15) days prior to the scheduled beginning of the
first Offering Period to be affected. Absent action by the Board, each Offering
Period shall be for a period of approximately twenty-four months (24) and new
Offering Periods shall commence on the first Trading Day of April and October of
each year and shall terminate on the last Trading Day in the September or March
twenty-four (24) months later; provided, however, that the first Offering Period
under the Plan shall commence on the First Commencement Date and shall terminate
on the last Trading Day in September 1993.

     5.   Participation.

          (a) An eligible Employee may become a participant in the Plan by
completing a subscription agreement authorizing payroll deductions in the form
of Exhibit A to this Plan and filing it with the Company's payroll office prior
to the applicable Enrollment Date.




                                      -3-
<PAGE>   90

          (b) Payroll deductions for a participant shall commence on the first
payroll period following the Enrollment Date and shall end on the last payroll
period in the Offering Period, unless sooner terminated by the participant as
provided in paragraph 10.

     6.   Payroll Deductions.

          (a) At the time a participant files his or her subscription agreement,
he or she shall elect to have payroll deductions made on each pay day during the
Offering Period in an amount not exceeding ten percent (10%) of the Compensation
which he or she receives on each pay day during the Offering Period, and the
aggregate of such payroll deductions during the Offering Period shall not exceed
ten percent (10%) of the participant's Compensation during said Offering Period.

          (b) All payroll deductions made for a participant shall be credited to
his or her account under the Plan and will be withheld in whole percentages
only. A participant may not make any additional payments into such account.

          (c) A participant may discontinue his or her participation in the Plan
as provided in paragraph 10, or may increase or decrease the rate of his or her
payroll deductions during the current Purchase Period by filing with the Company
a new subscription agreement authorizing such a change in the payroll deduction
rate. The change in rate shall be effective with the first full payroll period
following five (5) business days after the Company's receipt of the new
subscription agreement unless the Company elects to process a given change in
participation more quickly. A participant's subscription agreement shall remain
in effect for successive Purchase Periods and Offering Periods unless terminated
as provided in paragraph 10. The Board shall be authorized to limit the number
of participation rate changes during any Offering Period.

          (d) Notwithstanding the foregoing, to the extent necessary to comply
with Section 423(b)(8) of the Code and paragraph 3(b) herein, a participant's
payroll deductions may be decreased to 0% at such time during any Purchase
Period which is scheduled to end during the current calendar year (the "Current
Purchase Period") that the aggregate of all payroll deductions which were
previously used to purchase stock under the Plan in a prior Purchase Period
which ended during that calendar year plus all payroll deductions accumulated
with respect to the Current Purchase Period equal $21,250. Payroll deductions
shall recommence at the rate provided in such participant's subscription
agreement at the beginning of the first Purchase Period which is scheduled to
end in the following calendar year, unless terminated by the participant as
provided in paragraph 10.

          (e) At the time the option is exercised, in whole or in part, or at
the time some or all of the Company's Common Stock issued under the Plan is
disposed of, the participant must make adequate provision for the Company's
federal, state, or other tax withholding obligations, if any, which arise upon
the exercise of the option or the disposition of the Common Stock. At any time,
the Company may, but will not be obligated to, withhold from the participant's
compensation the amount necessary for the Company to meet applicable withholding
obligations, including any withholding required to 




                                      -4-
<PAGE>   91

make available to the Company any tax deductions or benefit attributable to sale
or early disposition of Common Stock by the Employee.

     7. Grant of Option. On the Enrollment Date of each Offering Period, each
eligible Employee participating in such Offering Period shall be granted an
option to purchase on each Exercise Date during such Offering Period (at the
applicable Purchase Price) up to a number of shares of the Company's Common
Stock determined by dividing such Employee's payroll deductions accumulated
prior to such Exercise Date and retained in the Participant's account as of the
Exercise Date by the applicable Purchase Price; provided that in no event shall
an Employee be permitted to purchase during each Purchase Period more than a
number of shares determined by dividing $12,500 by the fair market value of a
share of the Company's Common Stock on the Enrollment Date, and provided further
that such purchase shall be subject to the limitations set forth in Section 3(b)
and 12 hereof. Exercise of the option shall occur as provided in Section 8,
unless the participant has withdrawn pursuant to Section 10, and the option
shall expire on the last day of the Offering Period.

     8. Exercise of Option. Unless a participant withdraws from the Plan as
provided in paragraph 10 below, his or her option for the purchase of shares
will be exercised automatically on each Exercise Date, and the maximum number of
full shares subject to option shall be purchased for such participant at the
applicable Purchase Price with the accumulated payroll deductions in his or her
account. No fractional shares will be purchased; any payroll deductions
accumulated in a participant's account which are not sufficient to purchase a
full share shall be retained in the participant's account for the subsequent
Purchase Period, subject to earlier withdrawal by the participant as provided in
paragraph 10. Any other monies left over in a participant's account after the
Exercise Date shall be returned to the participant. During a participant's
lifetime, a participant's option to purchase shares hereunder is exercisable
only by him or her.

     9.   Delivery. As promptly as practicable after each Exercise Date on which
a purchase of shares occurs, the Company shall arrange the delivery to each
participant, as appropriate, of a certificate representing the shares purchased
upon exercise of his or her option.

     10.  Withdrawal; Termination of Employment.

          (a) A participant may withdraw all but not less than all the payroll
deductions credited to his or her account and not yet used to exercise his or
her option under the Plan at any time by giving written notice to the Company in
the form of Exhibit B to this Plan. All of the participant's payroll deductions
credited to his or her account will be paid to such participant promptly after
receipt of notice of withdrawal and such participant's option for the Offering
Period will be automatically terminated, and no further payroll deductions for
the purchase of shares will be made during the Offering Period. If a participant
withdraws from an Offering Period, payroll deductions will not resume at the
beginning of the succeeding Offering Period unless the participant delivers to
the Company a new subscription agreement.




                                      -5-
<PAGE>   92

          (b) Upon a participant's ceasing to be an Employee for any reason or
upon termination of a participant's employment relationship (as described in
Section 2(g)), the payroll deductions credited to such participant's account
during the Offering Period but not yet used to exercise the option will be
returned to such participant or, in the case of his or her death, to the person
or persons entitled thereto under paragraph 14, and such participant's option
will be automatically terminated.

     11.  Interest. No interest shall accrue on the payroll deductions of a
participant in the Plan.

     12.  Stock.

          (a) The maximum number of shares of the Company's Common Stock which
shall be made available for sale under the Plan shall be 150,000 shares, subject
to adjustment upon changes in capitalization of the Company as provided in
paragraph 18. If on a given Exercise Date the number of shares with respect to
which options are to be exercised exceeds the number of shares then available
under the Plan, the Company shall make a pro rata allocation of the shares
remaining available for purchase in as uniform a manner as shall be practicable
and as it shall determine to be equitable.

          (b) The participant will have no interest or voting right in shares
covered by his option until such option has been exercised.

          (c) Shares to be delivered to a participant under the Plan will be
registered in the name of the participant or in the name of the participant and
his or her spouse.

     13.  Administration.

          (a)  Administrative Body. The Plan shall be administered by the Board
of the Company or a committee of members of the Board appointed by the Board.
The Board or its committee shall have full and exclusive discretionary authority
to construe, interpret and apply the terms of the Plan, to determine eligibility
and to adjudicate all disputed claims filed under the Plan. Every finding,
decision and determination made by the Board or its committee shall, to the full
extent permitted by law, be final and binding upon all parties. Members of the
Board who are eligible Employees are permitted to participate in the Plan,
provided that:

               (1) Members of the Board who are eligible to participate in the
Plan may not vote on any matter affecting the administration of the Plan or the
grant of any option pursuant to the Plan.

               (2) If a Committee is established to administer the Plan, no
member of the Board who is eligible to participate in the Plan may be a member
of the Committee.

          (b)  Rule 16b-3 Limitations. Notwithstanding the provisions of
Subsection (a) of this Section 13, in the event that Rule 16b-3 promulgated
under The Securities Exchange Act of 1934, as amended, or any successor
provision ("Rule 16b-3") provides specific requirements for the 




                                      -6-
<PAGE>   93

administrators of plans of this type, the Plan shall be only administered by
such a body and in such a manner as shall comply with the applicable
requirements of Rule 16b-3. Unless permitted by Rule 16b-3, no discretion
concerning decisions regarding the Plan shall be afforded to any committee or
person that is not "disinterested" as that term is used in Rule 16b-3.

     14.  Designation of Beneficiary.

          (a) A participant may file a written designation of a beneficiary who
is to receive any shares and cash, if any, from the participant's account under
the Plan in the event of such participant's death subsequent to an Exercise Date
on which the option is exercised but prior to delivery to such participant of
such shares and cash. In addition, a participant may file a written designation
of a beneficiary who is to receive any cash from the participant's account under
the Plan in the event of such participant's death prior to exercise of the
option. If a participant is married and the designated beneficiary is not the
spouse, spousal consent shall be required for such designation to be effective.

          (b) Such designation of beneficiary may be changed by the participant
(and his or her spouse, if any) at any time by written notice. In the event of
the death of a participant and in the absence of a beneficiary validly
designated under the Plan who is living at the time of such participant's death,
the Company shall deliver such shares and/or cash to the executor or
administrator of the estate of the participant, or if no such executor or
administrator has been appointed (to the knowledge of the Company), the Company,
in its discretion, may deliver such shares and/or cash to the spouse or to any
one or more dependents or relatives of the participant, or if no spouse,
dependent or relative is known to the Company, then to such other person as the
Company may designate.

     15.  Transferability. Neither payroll deductions credited to a 
participant's account nor any rights with regard to the exercise of an option or
to receive shares under the Plan may be assigned, transferred, pledged or
otherwise disposed of in any way (other than by will, the laws of descent and
distribution or as provided in paragraph 14 hereof) by the participant. Any such
attempt at assignment, transfer, pledge or other disposition shall be without
effect, except that the Company may treat such act as an election to withdraw
funds from an Offering Period in accordance with paragraph 10.

     16.  Use of Funds. All payroll deductions received or held by the Company
under the Plan may be used by the Company for any corporate purpose, and the
Company shall not be obligated to segregate such payroll deductions.

     17.  Reports. Individual accounts will be maintained for each participant 
in the Plan. Statements of account will be given to participating Employees at
least annually, which statements will set forth the amounts of payroll
deductions, the Purchase Price, the number of shares purchased and the remaining
cash balance, if any.

     18.  Adjustments Upon Changes in Capitalization, Dissolution, Merger or
Asset Sale.




                                      -7-
<PAGE>   94

          (a) Changes in Capitalization. Subject to any required action by the
shareholders of the Company, the Reserves as well as the price per share of
Common Stock covered by each option under the Plan which has not yet been
exercised, shall be proportionately adjusted for any increase or decrease in the
number of issued shares of Common Stock resulting from a stock split, reverse
stock split, stock dividend, combination or reclassification of the Common
Stock, or any other increase or decrease in the number of shares of Common Stock
effected without receipt of consideration by the Company; provided, however,
that conversion of any convertible securities of the Company shall not be deemed
to have been "effected without receipt of consideration". Such adjustment shall
be made by the Board, whose determination in that respect shall be final,
binding and conclusive. Except as expressly provided herein, no issue by the
Company of shares of stock of any class, or securities convertible into shares
of stock of any class, shall affect, and no adjustment by reason thereof shall
be made with respect to, the number or price of shares of Common Stock subject
to an option. The Board may, if it so determines in the exercise of its sole
discretion, make provision for adjusting the Reserves, as well as the price per
share of Common Stock covered by each outstanding option, in the event the
Company effects one or more reorganizations, recapitalizations, rights offerings
or other increases or reductions of shares of its outstanding Common Stock. 

          (b) Dissolution or Liquidation. In the event of the proposed
dissolution or liquidation of the Company, the Offering Periods will terminate
immediately prior to the consummation of such proposed action, unless otherwise
provided by the Board.

          (c) Merger or Asset Sale. In the event of a proposed sale of all or
substantially all of the assets of the Company, or the merger of the Company
with or into another corporation, each option under the Plan shall be assumed or
an equivalent option shall be substituted by such successor corporation or a
parent or subsidiary of such successor corporation, unless the Board determines,
in the exercise of its sole discretion and in lieu of such assumption or
substitution, to shorten the Offering Periods then in progress by setting a new
Exercise Date (the "New Exercise Date"). If the Board shortens the Offering
Periods then in progress in lieu of assumption or substitution in the event of a
merger or sale of assets, the Board shall notify each participant in writing, at
least ten (10) days prior to the New Exercise Date, that the Exercise Date for
his option has been changed to the New Exercise Date and that his option will be
exercised automatically on the New Exercise Date, unless prior to such date he
has withdrawn from the Offering Period as provided in paragraph 10. For purposes
of this paragraph, an option granted under the Plan shall be deemed to be
assumed if, following the sale of assets or merger, the option confers the right
to purchase, for each share of option stock subject to the option immediately
prior to the sale of assets or merger, the consideration (whether stock, cash or
other securities or property) received in the sale of assets or merger by
holders of Common Stock for each share of Common Stock held on the effective
date of the transaction (and if such holders were offered a choice of
consideration, the type of consideration chosen by the holders of a majority of
the outstanding shares of Common Stock); provided, however, that if such
consideration received in the sale of assets or merger was not solely common
stock of the successor corporation or its parent (as defined in Section 424(e)
of the Code), the Board may, with the consent of the successor corporation and
the participant, provide for the consideration to be received upon exercise of
the option to be solely common stock of the successor corporation or its parent
equal in fair market value to the per share consideration received by holders of
Common Stock in the sale of assets or merger.




                                      -8-
<PAGE>   95

     19.  Amendment or Termination.

          (a) The Board of Directors of the Company may at any time and for any
reason terminate or amend the Plan. Except as provided in paragraph 18, no such
termination can affect options previously granted, provided that an Offering
Period may be terminated by the Board of Directors on any Exercise Date if the
Board determines that the termination of the Plan is in the best interests of
the Company and its shareholders. Except as provided in paragraph 18, no
amendment may make any change in any option theretofore granted which adversely
affects the rights of any participant. To the extent necessary to comply with
Rule 16b-3 or under Section 423 of the Code (or any successor rule or provision
or any other applicable law or regulation), the Company shall obtain shareholder
approval in such a manner and to such a degree as required.

          (b) Without shareholder consent and without regard to whether any
participant rights may be considered to have been "adversely affected," the
Board (or its committee) shall be entitled to change the Purchase Periods and/or
Offering Periods, limit the frequency and/or number of changes in the amount
withheld during Purchase Periods and/or Offering Periods, establish the exchange
ratio applicable to amounts withheld in a currency other than U.S. dollars,
permit payroll withholding in excess of the amount designated by a participant
in order to adjust for delays or mistakes in the Company's processing of
properly completed withholding elections, establish reasonable waiting and
adjustment periods and/or accounting and crediting procedures to ensure that
amounts applied toward the purchase of Common Stock for each participant
properly correspond with amounts withheld from the participant's Compensation,
and establish such other limitations or procedures as the Board (or its
committee) determines in its sole discretion advisable which are consistent with
the Plan.

     20.  Notices. All notices or other communications by a participant to the
Company under or in connection with the Plan shall be deemed to have been duly
given when received in the form specified by the Company at the location, or by
the person, designated by the Company for the receipt thereof.

     21.  Conditions Upon Issuance of Shares. Shares shall not be issued with
respect to an option unless the exercise of such option and the issuance and
delivery of such shares pursuant thereto shall comply with all applicable
provisions of law, domestic or foreign, including, without limitation, the
Securities Act of 1933, as amended, the Securities Exchange Act of 1934, as
amended, the rules and regulations promulgated thereunder, and the requirements
of any stock exchange upon which the shares may then be listed, and shall be
further subject to the approval of counsel for the Company with respect to such
compliance.

          As a condition to the exercise of an option, the Company may require
the person exercising such option to represent and warrant at the time of any
such exercise that the shares are being purchased only for investment and
without any present intention to sell or distribute such shares if, in the
opinion of counsel for the Company, such a representation is required by any of
the aforementioned applicable provisions of law.




                                      -9-
<PAGE>   96

     22.  Term of Plan. The Plan shall become effective upon the earlier to 
occur of its adoption by the Board of Directors or its approval by the
shareholders of the Company. It shall continue in effect for a term of twenty
(20) years unless sooner terminated under paragraph 19.

     23.  Additional Restrictions of Rule 16b-3. The terms and conditions of
options granted hereunder to, and the purchase of shares by, persons subject to
Section 16 of the Exchange Act shall comply with the applicable provisions of
Rule 16b-3. This Plan shall be deemed to contain, and such options shall
contain, and the shares issued upon exercise thereof shall be subject to, such
additional conditions and restrictions as may be required by Rule 16b-3 to
qualify for the maximum exemption from Section 16 of the Exchange Act with
respect to Plan transactions.

     24.  Automatic Transfer to Low Price Offering Period. To the extent
permitted by Rule 16b-3 of the Exchange Act, if the Fair Market Value of the
Common Stock on any Exercise Date in an Offering Period is lower than the Fair
Market Value of the Common Stock on the Enrollment Date of such Offering Period,
then all participants in such Offering Period shall be automatically withdrawn
from such Offering Period immediately after the exercise of their options on
such Exercise Date and automatically re-enrolled in the immediately following
Offering Period as of the first day thereof.






                                      -10-
<PAGE>   97


                                    EXHIBIT A


                                  ANERGEN, INC.

                        1991 EMPLOYEE STOCK PURCHASE PLAN

                             SUBSCRIPTION AGREEMENT



_____ Original Application                          Enrollment Date: ___________
_____ Change in Payroll Deduction Rate
_____ Change of Beneficiary(ies)


1.   hereby elects to participate in the Anergen, Inc. 1991 Employee Stock
     Purchase Plan (the "Employee Stock Purchase Plan") and subscribes to
     purchase shares of the Company's Common Stock in accordance with this
     Subscription Agreement and the Employee Stock Purchase Plan.

2.   I hereby authorize payroll deductions from each paycheck in the amount of
     ____% of my Compensation on each payday (not to exceed 10%) during the
     Offering Period in accordance with the Stock Purchase Plan. (Please note
     that no fractional percentages are permitted.)

3.   I understand that said payroll deductions shall be accumulated for the
     purchase of shares of Common Stock at the applicable Purchase Price
     determined in accordance with the Employee Stock Purchase Plan. I
     understand that if I do not withdraw from an Offering Period, any
     accumulated payroll deductions will be used to automatically exercise my
     option.

4.   I have received a copy of the complete "Anergen, Inc. 1991 Employee Stock
     Purchase Plan." I understand that my participation in the Employee Stock
     Purchase Plan is in all respects subject to the terms of the Plan. I
     understand that the grant of the option by the Company under this
     Subscription Agreement is subject to obtaining shareholder approval of the
     Employee Stock Purchase Plan.

5.   Shares purchased for me under the Employee Stock Purchase Plan should be
     issued in the name(s) of (employee and/or spouse only):____________________
     _____.

6.   I understand that if I dispose of any shares received by me pursuant to the
     Plan within 2 years after the Enrollment Date (the first day of the
     Offering Period during which I purchased such shares) or within 1 year
     after the Exercise Date (the date I purchased such shares), I will be
     treated for federal income tax purposes as having received ordinary income
     at the time of such 




                                      -1-
<PAGE>   98

     disposition in an amount equal to the excess of the fair market value of
     the shares at the time such shares were delivered to me over the price
     which I paid for the shares. I HEREBY AGREE TO NOTIFY THE COMPANY IN
     WRITING WITHIN 30 DAYS AFTER THE DATE OF ANY DISPOSITION OF MY SHARES AND I
     WILL MAKE ADEQUATE PROVISION FOR FEDERAL, STATE OR OTHER TAX WITHHOLDING
     OBLIGATIONS, IF ANY, WHICH ARISE UPON THE DISPOSITION OF THE COMMON STOCK.
     The Company may, but will not be obligated to, withhold from my
     compensation the amount necessary to meet any applicable withholding
     obligation including any withholding necessary to make available to the
     Company any tax deductions or benefits attributable to sale or early
     disposition of Common Stock by me. If I dispose of such shares at any time
     after the expiration of the 1-year and 2-year holding periods described
     above, I understand that I will be treated for federal income tax purposes
     as having received income only at the time of such disposition, and that
     such income will be taxed as ordinary income only to the extent of an
     amount equal to the lesser of (1) the excess of the fair market value of
     the shares at the time of such disposition over the purchase price which I
     paid for the shares, or (2) 15% of the fair market value of the shares on
     the first day of the Offering Period. The remainder of the gain, if any,
     recognized on such disposition will be taxed as capital gain. I UNDERSTAND
     THAT THIS TAX SUMMARY IS ONLY A SUMMARY AND IS SUBJECT TO CHANGE.

7.   I hereby agree to be bound by the terms of the Employee Stock Purchase
     Plan. The effectiveness of this Subscription Agreement is dependent upon my
     eligibility to participate in the Employee Stock Purchase Plan.

8.   In the event of my death, I hereby designate the following as my
     beneficiary(ies) to receive all payments and shares due me under the
     Employee Stock Purchase Plan:



NAME: (Please print) ___________________________________________________________
                           (First)         (Middle)               (Last)


- --------------------------   ---------------------------------------------------
Relationship

                             ---------------------------------------------------
                             (Address)


NAME: (Please print)____________________________________________________________
                           (First)         (Middle)               (Last)




                                      -2-
<PAGE>   99


- --------------------------   ---------------------------------------------------
Relationship

                             ---------------------------------------------------
                             (Address)


Employee's Social
Security Number:
                             ---------------------------------------------------


Employee's Address:
                             ---------------------------------------------------

                             ---------------------------------------------------

                             ---------------------------------------------------


I UNDERSTAND THAT THIS SUBSCRIPTION AGREEMENT SHALL REMAIN IN EFFECT THROUGHOUT
SUCCESSIVE OFFERING PERIODS UNLESS TERMINATED BY ME.



Dated:
      ---------------                   ----------------------------------------
                                        Signature of Employee


                                        ----------------------------------------
                                        Spouse's Signature 
                                        (If beneficiary other than spouse)




                                      -3-
<PAGE>   100

                                    EXHIBIT B


                                  ANERGEN, INC.

                        1991 EMPLOYEE STOCK PURCHASE PLAN

                              NOTICE OF WITHDRAWAL



     The undersigned participant in the Offering Period of the Anergen, Inc.
1991 Employee Stock Purchase Plan which began on ____________, 19____ (the
"Enrollment Date") hereby notifies the Company that he or she hereby withdraws
from the Offering Period. He or she hereby directs the Company to pay to the
undersigned as promptly as practicable all the payroll deductions credited to
his or her account with respect to such Offering Period. The undersigned
understands and agrees that his or her option for such Offering Period will be
automatically terminated. The undersigned understands further that no further
payroll deductions will be made for the purchase of shares in the current
Offering Period and the undersigned shall be eligible to participate in
succeeding Offering Periods only by delivering to the Company a new Subscription
Agreement.

                                        Name and Address of Participant


                                        ----------------------------------------


                                        ----------------------------------------


                                        ----------------------------------------


                                        Signature


                                        ----------------------------------------


                                        Date:
                                             -----------------------------------




                                      -4-
<PAGE>   101
                                                                       Exhibit 2



                                  ANERGEN, INC.

                                 1996 STOCK PLAN



     1.   Purposes of the Plan. The purposes of this Stock Plan are:

          o    to attract and retain the best available personnel for positions
               of substantial responsibility,

          o    to provide additional incentive to Employees, Directors and
               Consultants, and

          o    to promote the success of the Company's business.

     Options granted under the Plan may be Incentive Stock Options or
Nonstatutory Stock Options, as determined by the Administrator at the time of
grant. Stock Purchase Rights may also be granted under the Plan.

     2.   Definitions. As used herein, the following definitions shall apply:

          (a) "Administrator" means the Board or any of its Committees as shall
be administering the Plan, in accordance with Section 4 of the Plan.
               
          (b) "Applicable Laws" means the requirements relating to the
administration of stock option plans under U. S. state corporate laws, U.S.
federal and state securities laws, the Code, any stock exchange or quotation
system on which the Common Stock is listed or quoted and the applicable laws of
any foreign country or jurisdiction where Options or Stock Purchase Rights are,
or will be, granted under the Plan.

          (c) "Board" means the Board of Directors of the Company.

          (d) "Code" means the Internal Revenue Code of 1986, as amended.

          (e) "Committee" means a committee of Directors appointed by the Board
in accordance with Section 4 of the Plan.

          (f) "Common Stock" means the Common Stock of the Company.

          (g) "Company" means Anergen, Inc., a California corporation.

          (h) "Consultant" means any person, including an advisor, engaged by
the Company or a Parent or Subsidiary to render services to such entity. 




<PAGE>   102

          (i) "Director" means a member of the Board.

          (j) "Disability" means total and permanent disability as defined in
Section 22(e)(3) of the Code.

          (k) "Employee" means any person, including Officers and Directors,
employed by the Company or any Parent or Subsidiary of the Company. A Service
Provider shall not cease to be an Employee in the case of (i) any leave of
absence approved by the Company or (ii) transfers between locations of the
Company or between the Company, its Parent, any Subsidiary, or any successor.
For purposes of Incentive Stock Options, no such leave may exceed ninety days,
unless reemployment upon expiration of such leave is guaranteed by statute or
contract. If reemployment upon expiration of a leave of absence approved by the
Company is not so guaranteed, on the 181st day of such leave any Incentive Stock
Option held by the Optionee shall cease to be treated as an Incentive Stock
Option and shall be treated for tax purposes as a Nonstatutory Stock Option.
Neither service as a Director nor payment of a director's fee by the Company
shall be sufficient to constitute "employment" by the Company.

          (l) "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

          (m) "Fair Market Value" means, as of any date, the value of Common
Stock determined as follows:

              (i) If the Common Stock is listed on any established stock
exchange or a national market system, including without limitation the Nasdaq
National Market or The Nasdaq SmallCap Market of The Nasdaq Stock Market, its
Fair Market Value shall be the closing sales price for such stock (or the
closing bid, if no sales were reported) as quoted on such exchange or system for
the last market trading day prior to the time of determination, as reported in
The Wall Street Journal or such other source as the Administrator deems
reliable;

              (ii) If the Common Stock is regularly quoted by a recognized
securities dealer but selling prices are not reported, the Fair Market Value of
a Share of Common Stock shall be the mean between the high bid and low asked
prices for the Common Stock on the last market trading day prior to the day of
determination, as reported in The Wall Street Journal or such other source as
the Administrator deems reliable;

               (iii) In the absence of an established market for the Common
Stock, the Fai Market Value shall be determined in good faith by the
Administrator.

          (n) "Incentive Stock Option" means an Option intended to qualify as an
incentive stock option within the meaning of Section 422 of the Code and the
regulations promulgated thereunder.

          (o) "Nonstatutory Stock Option" means an Option not intended to
qualify as an Incentive Stock Option.




                                      -2-
<PAGE>   103

          (p) "Notice of Grant" means a written or electronic notice evidencing
certain terms and conditions of an individual Option or Stock Purchase Right
grant. The Notice of Grant is part of the Option Agreement.

          (q) "Officer" means a person who is an officer of the Company within
the meaning of Section 16 of the Exchange Act and the rules and regulations
promulgated thereunder.

          (r) "Option" means a stock option granted pursuant to the Plan.

          (s) "Option Agreement" means an agreement between the Company and an
Optionee evidencing the terms and conditions of an individual Option grant. The
Option Agreement is subject to the terms and conditions of the Plan.

          (t) "Option Exchange Program" means a program whereby outstanding
options are surrendered in exchange for options with a lower exercise price.

          (u) "Optioned Stock" means the Common Stock subject to an Option or
Stock Purchase Right.

          (v) "Optionee" means the holder of an outstanding Option or Stock
Purchase Right granted under the Plan.

          (w) "Parent" means a "parent corporation," whether now or hereafter
existing, as defined in Section 424(e) of the Code.

          (x) "Plan" means this Anergen, Inc. 1996 Stock Plan.

          (y) "Restricted Stock" means shares of Common Stock acquired pursuant
to a grant of Stock Purchase Rights under Section 11 below.

          (z) "Restricted Stock Purchase Agreement" means a written agreement
between the Company and the Optionee evidencing the terms and restrictions
applying to stock purchased under a Stock Purchase Right. The Restricted Stock
Purchase Agreement is subject to the terms and conditions of the Plan and the
Notice of Grant.

          (aa) "Rule 16b-3" means Rule 16b-3 of the Exchange Act or any
successor to Rule 16b-3, as in effect when discretion is being exercised with
respect to the Plan.

          (bb) "Section 16(b)" means Section 16(b) of the Exchange Act.

          (cc) "Service Provider" means an Employee, Director or Consultant.

          (dd) "Share" means a share of the Common Stock, as adjusted in
accordance with Section 13 of the Plan.




                                      -3-
<PAGE>   104

          (ee) "Stock Purchase Right" means the right to purchase Common Stock
pursuant to Section 11 of the Plan, as evidenced by a Notice of Grant.

          (ff) "Subsidiary" means a "subsidiary corporation", whether now or
hereafter existing, as defined in Section 424(f) of the Code.

     3.   Stock Subject to the Plan. Subject to the provisions of Section 13 of
the Plan, the maximum aggregate number of Shares which may be optioned and sold
under the Plan is 1,000,000 Shares. The Shares may be authorized, but unissued,
or reacquired Common Stock.

          If an Option or Stock Purchase Right expires or becomes unexercisable
without having been exercised in full, or is surrendered pursuant to an Option
Exchange Program, the unpurchased Shares which were subject thereto shall become
available for future grant or sale under the Plan (unless the Plan has
terminated); provided, however, that Shares that have actually been issued under
the Plan, whether upon exercise of an Option or Right, shall not be returned to
the Plan and shall not become available for future distribution under the Plan,
except that if Shares of Restricted Stock are repurchased by the Company at
their original purchase price, such Shares shall become available for future
grant under the Plan.

     4.   Administration of the Plan.

          (a)  Procedure.

               (i) Multiple Administrative Bodies. The Plan may be administered
by different Committees with respect to different groups of Service Providers.

               (ii) Section 162(m). To the extent that the Administrator
determines it to be desirable to qualify Options granted hereunder as
"performance-based compensation" within the meaning of Section 162(m) of the
Code, the Plan shall be administered by a Committee of two or more "outside
directors" within the meaning of Section 162(m) of the Code.

               (iii) Rule 16b-3. To the extent desirable to qualify transactions
hereunder as exempt under Rule 16b-3, the transactions contemplated hereunder
shall be structured to satisfy the requirements for exemption under Rule 16b-3.

               (iv) Other Administration. Other than as provided above, the Plan
shall be administered by (A) the Board or (B) a Committee, which committee shall
be constituted to satisfy Applicable Laws.

          (b)  Powers of the Administrator. Subject to the provisions of the
Plan, and in the case of a Committee, subject to the specific duties delegated
by the Board to such Committee, the Administrator shall have the authority, in
its discretion:

               (i) to determine the Fair Market Value;




                                      -4-
<PAGE>   105

               (ii) to select the Service Providers to whom Options and Stock
Purchase Rights may be granted hereunder;

               (iii) to determine the number of shares of Common Stock to be
covered by each Option and Stock Purchase Right granted hereunder;

               (iv) to approve forms of agreement for use under the Plan;

               (v) to determine the terms and conditions, not inconsistent with
the terms of the Plan, of any Option or Stock Purchase Right granted hereunder.
Such terms and conditions include, but are not limited to, the exercise price,
the time or times when Options or Stock Purchase Rights may be exercised (which
may be based on performance criteria), any vesting acceleration or waiver of
forfeiture restrictions, and any restriction or limitation regarding any Option
or Stock Purchase Right or the shares of Common Stock relating thereto, based in
each case on such factors as the Administrator, in its sole discretion, shall
determine;

               (vi) to reduce the exercise price of any Option or Stock Purchase
Right to the then current Fair Market Value if the Fair Market Value of the
Common Stock covered by such Option or Stock Purchase Right shall have declined
since the date the Option or Stock Purchase Right was granted;

               (vii) to institute an Option Exchange Program;

               (viii) to construe and interpret the terms of the Plan and awards
granted pursuant to the Plan;

               (ix) to prescribe, amend and rescind rules and regulations
relating to the Plan, including rules and regulations relating to sub-plans
established for the purpose of qualifying for preferred tax treatment under
foreign tax laws;

               (x) to modify or amend each Option or Stock Purchase Right
(subject to Section 15(c) of the Plan), including the discretionary authority to
extend the post-termination exercisability period of Options longer than is
otherwise provided for in the Plan;

               (xi) to allow Optionees to satisfy withholding tax obligations by
electing to have the Company withhold from the Shares to be issued upon exercise
of an Option or Stock Purchase Right that number of Shares having a Fair Market
Value equal to the amount required to be withheld. The Fair Market Value of the
Shares to be withheld shall be determined on the date that the amount of tax to
be withheld is to be determined. All elections by an Optionee to have Shares
withheld for this purpose shall be made in such form and under such conditions
as the Administrator may deem necessary or advisable;




                                      -5-
<PAGE>   106

               (xii) to authorize any person to execute on behalf of the Company
any instrument required to effect the grant of an Option or Stock Purchase Right
previously granted by the Administrator;

               (xiii) to make all other determinations deemed necessary or
advisable for administering the Plan.

          (c)  Effect of Administrator's Decision. The Administrator's 
decisions, determinations and interpretations shall be final and binding on all
Optionees and any other holders of Options or Stock Purchase Rights.

     5.   Eligibility. Nonstatutory Stock Options and Stock Purchase Rights may 
be granted to Service Providers. Incentive Stock Options may be granted only to
Employees.

     6.   Limitations.

          (a)  Each Option shall be designated in the Option Agreement as either
an Incentive Stock Option or a Nonstatutory Stock Option. However,
notwithstanding such designation, to the extent that the aggregate Fair Market
Value of the Shares with respect to which Incentive Stock Options are
exercisable for the first time by the Optionee during any calendar year (under
all plans of the Company and any Parent or Subsidiary) exceeds $100,000, such
Options shall be treated as Nonstatutory Stock Options. For purposes of this
Section 6(a), Incentive Stock Options shall be taken into account in the order
in which they were granted. The Fair Market Value of the Shares shall be
determined as of the time the Option with respect to such Shares is granted.

          (b)  Neither the Plan nor any Option or Stock Purchase Right shall
confer upon an Optionee any right with respect to continuing the Optionee's
relationship as a Service Provider with the Company, nor shall they interfere in
any way with the Optionee's right or the Company's right to terminate such
relationship at any time, with or without cause.

          (c)  The following limitations shall apply to grants of Options:

               (i) No Service Provider shall be granted, in any fiscal year of
the Company, Options to purchase more than 500,000 Shares.

               (ii) In connection with his or her initial service, a Service
Provider may be granted Options to purchase up to an additional 500,000 Shares
which shall not count against the limit set forth in subsection (i) above.

               (iii) The foregoing limitations shall be adjusted proportionately
in connection with any change in the Company's capitalization as described in
Section 13.

               (iv) If an Option is cancelled in the same fiscal year of the
Company in which it was granted (other than in connection with a transaction
described in Section 13), the cancelled 




                                      -6-
<PAGE>   107

Option will be counted against the limits set forth in subsections (i) and (ii)
above. For this purpose, if the exercise price of an Option is reduced, the
transaction will be treated as a cancellation of the Option and the grant of a
new Option.

     7.   Term of Plan. Subject to Section 19 of the Plan, the Plan shall become
effective upon its adoption by the Board. It shall continue in effect for a term
of ten (10) years unless terminated earlier under Section 15 of the Plan.

     8.   Term of Option. The term of each Option shall be stated in the Option
Agreement. In the case of an Incentive Stock Option, the term shall be ten (10)
years from the date of grant or such shorter term as may be provided in the
Option Agreement. Moreover, in the case of an Incentive Stock Option granted to
an Optionee who, at the time the Incentive Stock Option is granted, owns stock
representing more than ten percent (10%) of the voting power of all classes of
stock of the Company or any Parent or Subsidiary, the term of the Incentive
Stock Option shall be five (5) years from the date of grant or such shorter term
as may be provided in the Option Agreement.

     9.   Option Exercise Price and Consideration.

          (a)  Exercise Price. The per share exercise price for the Shares to be
issued pursuant to exercise of an Option shall be determined by the
Administrator, subject to the following:

               (i) In the case of an Incentive Stock Option

                   (A) granted to an Employee who, at the time the Incentive
Stock Option is granted, owns stock representing more than ten percent (10%) of
the voting power of all classes of stock of the Company or any Parent or
Subsidiary, the per Share exercise price shall be no less than 110% of the Fair
Market Value per Share on the date of grant.

                   (B) granted to any Employee other than an Employee described
in paragraph (A) immediately above, the per Share exercise price shall be no
less than 100% of the Fair Market Value per Share on the date of grant.

               (ii) In the case of a Nonstatutory Stock Option, the per Share
exercise price shall be determined by the Administrator. In the case of a
Nonstatutory Stock Option intended to qualify as "performance-based
compensation" within the meaning of Section 162(m) of the Code, the per Share
exercise price shall be no less than 100% of the Fair Market Value per Share on
the date of grant.

               (iii) Notwithstanding the foregoing, Options may be granted with
a per Share exercise price of less than 100% of the Fair Market Value per Share
on the date of grant pursuant to a merger or other corporate transaction.




                                      -7-
<PAGE>   108

          (b)  Waiting Period and Exercise Dates. At the time an Option is
granted, the Administrator shall fix the period within which the Option may be
exercised and shall determine any conditions which must be satisfied before the
Option may be exercised.

          (c)  Form of Consideration. The Administrator shall determine the
acceptable form of consideration for exercising an Option, including the method
of payment. In the case of an Incentive Stock Option, the Administrator shall
determine the acceptable form of consideration at the time of grant. Such
consideration may consist entirely of:

               (i) cash;

               (ii) check;

               (iii) promissory note;

               (iv) other Shares which (A) in the case of Shares acquired upon
exercise of an option, have been owned by the Optionee for more than six months
on the date of surrender, and (B) have a Fair Market Value on the date of
surrender equal to the aggregate exercise price of the Shares as to which said
Option shall be exercised;

               (v) consideration received by the Company under a cashless
exercise program implemented by the Company in connection with the Plan;

               (vi) a reduction in the amount of any Company liability to the
Optionee, including any liability attributable to the Optionee's participation
in any Company-sponsored deferred compensation program or arrangement;

               (vii) any combination of the foregoing methods of payment; or

               (viii) such other consideration and method of payment for the
issuance of Shares to the extent permitted by Applicable Laws.

     10.  Exercise of Option.

          (a) Procedure for Exercise; Rights as a Shareholder. Any Option
granted hereunder shall be exercisable according to the terms of the Plan and at
such times and under such conditions as determined by the Administrator and set
forth in the Option Agreement. Unless the Administrator provides otherwise,
vesting of Options granted hereunder shall be tolled during any unpaid leave of
absence. An Option may not be exercised for a fraction of a Share.

               An Option shall be deemed exercised when the Company receives:
(i) written or electronic notice of exercise (in accordance with the Option
Agreement) from the person entitled to exercise the Option, and (ii) full
payment for the Shares with respect to which the Option is exercised. Full
payment may consist of any consideration and method of payment authorized by the




                                      -8-
<PAGE>   109

Administrator and permitted by the Option Agreement and the Plan. Shares issued
upon exercise of an Option shall be issued in the name of the Optionee or, if
requested by the Optionee, in the name of the Optionee and his or her spouse.
Until the Shares are issued (as evidenced by the appropriate entry on the books
of the Company or of a duly authorized transfer agent of the Company), no right
to vote or receive dividends or any other rights as a shareholder shall exist
with respect to the Optioned Stock, notwithstanding the exercise of the Option.
The Company shall issue (or cause to be issued) such Shares promptly after the
Option is exercised. No adjustment will be made for a dividend or other right
for which the record date is prior to the date the Shares are issued, except as
provided in Section 13 of the Plan.

               Exercising an Option in any manner shall decrease the number of
Shares thereafter available, both for purposes of the Plan and for sale under
the Option, by the number of Shares as to which the Option is exercised.

          (b) Termination of Relationship as a Service Provider. If an Optionee
ceases to be a Service Provider, other than upon the Optionee's death or
Disability, the Optionee may exercise his or her Option within such period of
time as is specified in the Option Agreement to the extent that the Option is
vested on the date of termination (but in no event later than the expiration of
the term of such Option as set forth in the Option Agreement). In the absence of
a specified time in the Option Agreement, the Option shall remain exercisable
for three (3) months following the Optionee's termination. If, on the date of
termination, the Optionee is not vested as to his or her entire Option, the
Shares covered by the unvested portion of the Option shall revert to the Plan.
If, after termination, the Optionee does not exercise his or her Option within
the time specified by the Administrator, the Option shall terminate, and the
Shares covered by such Option shall revert to the Plan.

          (c) Disability of Optionee. If an Optionee ceases to be a Service
Provider as a result of the Optionee's Disability, the Optionee may exercise his
or her Option within such period of time as is specified in the Option Agreement
to the extent the Option is vested on the date of termination (but in no event
later than the expiration of the term of such Option as set forth in the Option
Agreement). In the absence of a specified time in the Option Agreement, the
Option shall remain exercisable for twelve (12) months following the Optionee's
termination. If, on the date of termination, the Optionee is not vested as to
his or her entire Option, the Shares covered by the unvested portion of the
Option shall revert to the Plan. If, after termination, the Optionee does not
exercise his or her Option within the time specified herein, the Option shall
terminate, and the Shares covered by such Option shall revert to the Plan.

          (d) Death of Optionee. If an Optionee dies while a Service Provider,
the Option may be exercised within such period of time as is specified in the
Option Agreement (but in no event later than the expiration of the term of such
Option as set forth in the Notice of Grant), by the Optionee's estate or by a
person who acquires the right to exercise the Option by bequest or inheritance,
but only to the extent that the Option is vested on the date of death. In the
absence of a specified time in the Option Agreement, the Option shall remain
exercisable for twelve (12) months following the Optionee's termination. If, at
the time of death, the Optionee is not vested as to his or her entire 





                                      -9-
<PAGE>   110

Option, the Shares covered by the unvested portion of the Option shall
immediately revert to the Plan. The Option may be exercised by the executor or
administrator of the Optionee's estate or, if none, by the person(s) entitled to
exercise the Option under the Optionee's will or the laws of descent or
distribution. If the Option is not so exercised within the time specified
herein, the Option shall terminate, and the Shares covered by such Option shall
revert to the Plan.

          (e) Buyout Provisions. The Administrator may at any time offer to buy
out for a payment in cash or Shares, an Option previously granted based on such
terms and conditions as the Administrator shall establish and communicate to the
Optionee at the time that such offer is made.

     11.  Stock Purchase Rights.

          (a) Rights to Purchase. Stock Purchase Rights may be issued either
alone, in addition to, or in tandem with other awards granted under the Plan
and/or cash awards made outside of the Plan. After the Administrator determines
that it will offer Stock Purchase Rights under the Plan, it shall advise the
offeree in writing or electronically, by means of a Notice of Grant, of the
terms, conditions and restrictions related to the offer, including the number of
Shares that the offeree shall be entitled to purchase, the price to be paid, and
the time within which the offeree must accept such offer. The offer shall be
accepted by execution of a Restricted Stock Purchase Agreement in the form
determined by the Administrator.

          (b) Repurchase Option. Unless the Administrator determines otherwise,
the Restricted Stock Purchase Agreement shall grant the Company a repurchase
option exercisable upon the voluntary or involuntary termination of the
purchaser's service with the Company for any reason (including death or
Disability). The purchase price for Shares repurchased pursuant to the
Restricted Stock purchase agreement shall be the original price paid by the
purchaser and may be paid by cancellation of any indebtedness of the purchaser
to the Company. The repurchase option shall lapse at a rate determined by the
Administrator.

          (c) Other Provisions. The Restricted Stock Purchase Agreement shall
contain such other terms, provisions and conditions not inconsistent with the
Plan as may be determined by the Administrator in its sole discretion.

          (d) Rights as a Shareholder. Once the Stock Purchase Right is
exercised, the purchaser shall have the rights equivalent to those of a
shareholder, and shall be a shareholder when his or her purchase is entered upon
the records of the duly authorized transfer agent of the Company. No adjustment
will be made for a dividend or other right for which the record date is prior to
the date the Stock Purchase Right is exercised, except as provided in Section 13
of the Plan.

     12. Non-Transferability of Options and Stock Purchase Rights. Unless
determined otherwise by the Administrator, an Option or Stock Purchase Right may
not be sold, pledged, assigned, hypothecated, transferred, or disposed of in any
manner other than by will or by the laws of descent or distribution and may be
exercised, during the lifetime of the Optionee, only by the Optionee. If the
Administrator makes an Option or Stock Purchase Right transferable, such Option




                                      -10-
<PAGE>   111

or Stock Purchase Right shall contain such additional terms and conditions as
the Administrator deems appropriate.

     13.  Adjustments Upon Changes in Capitalization, Dissolution, Merger or
Asset Sale.

          (a) Changes in Capitalization. Subject to any required action by the
shareholders of the Company, the number of shares of Common Stock covered by
each outstanding Option and Stock Purchase Right, and the number of shares of
Common Stock which have been authorized for issuance under the Plan but as to
which no Options or Stock Purchase Rights have yet been granted or which have
been returned to the Plan upon cancellation or expiration of an Option or Stock
Purchase Right, as well as the price per share of Common Stock covered by each
such outstanding Option or Stock Purchase Right, shall be proportionately
adjusted for any increase or decrease in the number of issued shares of Common
Stock resulting from a stock split, reverse stock split, stock dividend,
combination or reclassification of the Common Stock, or any other increase or
decrease in the number of issued shares of Common Stock effected without receipt
of consideration by the Company; provided, however, that conversion of any
convertible securities of the Company shall not be deemed to have been "effected
without receipt of consideration." Such adjustment shall be made by the Board,
whose determination in that respect shall be final, binding and conclusive.
Except as expressly provided herein, no issuance by the Company of shares of
stock of any class, or securities convertible into shares of stock of any class,
shall affect, and no adjustment by reason thereof shall be made with respect to,
the number or price of shares of Common Stock subject to an Option or Stock
Purchase Right.

          (b) Dissolution or Liquidation. In the event of the proposed
dissolution or liquidation of the Company, the Administrator shall notify each
Optionee as soon as practicable prior to the effective date of such proposed
transaction. The Administrator in its discretion may provide for an Optionee to
have the right to exercise his or her Option until ten (10) days prior to such
transaction as to all of the Optioned Stock covered thereby, including Shares as
to which the Option would not otherwise be exercisable. In addition, the
Administrator may provide that any Company repurchase option applicable to any
Shares purchased upon exercise of an Option or Stock Purchase Right shall lapse
as to all such Shares, provided the proposed dissolution or liquidation takes
place at the time and in the manner contemplated. To the extent it has not been
previously exercised, an Option or Stock Purchase Right will terminate
immediately prior to the consummation of such proposed action.

          (c) Merger or Asset Sale. In the event of a merger of the Company with
or into another corporation, or the sale of substantially all of the assets of
the Company, each outstanding Option and Stock Purchase Right shall be assumed
or an equivalent option or right substituted by the successor corporation or a
Parent or Subsidiary of the successor corporation. In the event that the
successor corporation refuses to assume or substitute for the Option or Stock
Purchase Right, the Optionee shall fully vest in and have the right to exercise
the Option or Stock Purchase Right as to all of the Optioned Stock, including
Shares as to which it would not otherwise be vested or exercisable. If an Option
or Stock Purchase Right becomes fully vested and exercisable in lieu of




                                      -11-
<PAGE>   112

assumption or substitution in the event of a merger or sale of assets, the
Administrator shall notify the Optionee in writing or electronically that the
Option or Stock Purchase Right shall be fully vested and exercisable for a
period of fifteen (15) days from the date of such notice, and the Option or
Stock Purchase Right shall terminate upon the expiration of such period. For the
purposes of this paragraph, the Option or Stock Purchase Right shall be
considered assumed if, following the merger or sale of assets, the option or
right confers the right to purchase or receive, for each Share of Optioned Stock
subject to the Option or Stock Purchase Right immediately prior to the merger or
sale of assets, the consideration (whether stock, cash, or other securities or
property) received in the merger or sale of assets by holders of Common Stock
for each Share held on the effective date of the transaction (and if holders
were offered a choice of consideration, the type of consideration chosen by the
holders of a majority of the outstanding Shares); provided, however, that if
such consideration received in the merger or sale of assets is not solely common
stock of the successor corporation or its Parent, the Administrator may, with
the consent of the successor corporation, provide for the consideration to be
received upon the exercise of the Option or Stock Purchase Right, for each Share
of Optioned Stock subject to the Option or Stock Purchase Right, to be solely
common stock of the successor corporation or its Parent equal in fair market
value to the per share consideration received by holders of Common Stock in the
merger or sale of assets.

     14.  Date of Grant. The date of grant of an Option or Stock Purchase Right
shall be, for all purposes, the date on which the Administrator makes the
determination granting such Option or Stock Purchase Right, or such other later
date as is determined by the Administrator. Notice of the determination shall be
provided to each Optionee within a reasonable time after the date of such grant.

     15.  Amendment and Termination of the Plan.

          (a) Amendment and Termination. The Board may at any time amend, alter,
suspend or terminate the Plan.

          (b) Shareholder Approval. The Company shall obtain shareholder
approval of any Plan amendment to the extent necessary and desirable to comply
with Applicable Laws.

          (c) Effect of Amendment or Termination. No amendment, alteration,
suspension or termination of the Plan shall impair the rights of any Optionee,
unless mutually agreed otherwise between the Optionee and the Administrator,
which agreement must be in writing and signed by the Optionee and the Company.
Termination of the Plan shall not affect the Administrator's ability to exercise
the powers granted to it hereunder with respect to options granted under the
Plan prior to the date of such termination.




                                      -12-
<PAGE>   113

     16.  Conditions Upon Issuance of Shares.

          (a) Legal Compliance. Shares shall not be issued pursuant to the
exercise of an Option or Stock Purchase Right unless the exercise of such Option
or Stock Purchase Right and the issuance and delivery of such Shares shall
comply with Applicable Laws and shall be further subject to the approval of
counsel for the Company with respect to such compliance.

          (b) Investment Representations. As a condition to the exercise of an
Option or Stock Purchase Right, the Company may require the person exercising
such Option or Stock Purchase Right to represent and warrant at the time of any
such exercise that the Shares are being purchased only for investment and
without any present intention to sell or distribute such Shares if, in the
opinion of counsel for the Company, such a representation is required.

     17.  Inability to Obtain Authority. The inability of the Company to obtain
authority from any regulatory body having jurisdiction, which authority is
deemed by the Company's counsel to be necessary to the lawful issuance and sale
of any Shares hereunder, shall relieve the Company of any liability in respect
of the failure to issue or sell such Shares as to which such requisite authority
shall not have been obtained.

     18.  Reservation of Shares. The Company, during the term of this Plan, will
at all times reserve and keep available such number of Shares as shall be
sufficient to satisfy the requirements of the Plan.

     19.  Shareholder Approval. The Plan shall be subject to approval by the
shareholders of the Company within twelve (12) months after the date the Plan is
adopted. Such shareholder approval shall be obtained in the manner and to the
degree required under Applicable Laws.




                                      -13-
<PAGE>   114


                                  ANERGEN, INC.

                             STOCK OPTION AGREEMENT


     Unless otherwise defined herein, the terms defined in the Anergen, Inc.
1996 Stock Plan (the "Plan") shall have the same defined meanings in this Option
Agreement.

I.  NOTICE OF STOCK OPTION GRANT

[Optionee's Name and Address]

     You have been granted an option to purchase Common Stock of the Company,
subject to the terms and conditions of the Plan and this Option Agreement, as
follows:

<TABLE>
<S>                                        <C>
       Grant Number                         _________________________

       Date of Grant                        _________________________

       Vesting Commencement Date                 _________________________

       Exercise Price per Share             $________________________

       Total Number of Shares Granted       _________________________

       Total Exercise Price                 $_________________________

       Type of Option:                      ___    Incentive Stock Option

                                            ___    Nonstatutory Stock Option

       Term/Expiration Date:                _________________________
</TABLE>


     Vesting Schedule:

     This Option may be exercised, in whole or in part, in accordance with the
following schedule:

     The Shares subject to the Option shall vest over a four year period at the
rate of 6/48th of the Shares six months after the Vesting Commencement Date, and
1/48 of the Shares subject to the Option shall vest each month thereafter,
subject to the Optionee continuing to be a Service Provider on such dates.




                                      -1-
<PAGE>   115

     Termination Period:

     Except as otherwise provided herein, this Option may be exercised for three
months after Optionee ceases to be a Service Provider. Upon the death or
Disability of the Optionee, this Option may be exercised for such longer period
as provided in the Plan. In no event shall this Option be exercised later than
the Term/Expiration Date as provided above.

II.  AGREEMENT

     1.  Grant of Option. The Plan Administrator of the Company hereby grants to
the Optionee named in the Notice of Grant attached as Part I of this Agreement
(the "Optionee") an option (the "Option") to purchase the number of Shares, as
set forth in the Notice of Grant, at the exercise price per share set forth in
the Notice of Grant (the "Exercise Price"), subject to the terms and conditions
of the Plan, which is incorporated herein by reference. Subject to Section 15(c)
of the Plan, in the event of a conflict between the terms and conditions of the
Plan and the terms and conditions of this Option Agreement, the terms and
conditions of the Plan shall prevail.

          If designated in the Notice of Grant as an Incentive Stock Option
("ISO"), this Option is intended to qualify as an Incentive Stock Option under
Section 422 of the Code. However, if this Option is intended to be an Incentive
Stock Option, to the extent that it exceeds the $100,000 rule of Code Section
422(d) it shall be treated as a Nonstatutory Stock Option ("NSO").

     2.   Exercise of Option.

          (a) Right to Exercise. This Option is exercisable during its term in
accordance with the Vesting Schedule set out in the Notice of Grant and the
applicable provisions of the Plan and this Option Agreement.

          (b) Method of Exercise. This Option is exercisable by delivery of an
exercise notice, in the form attached as Exhibit A (the "Exercise Notice"),
which shall state the election to exercise the Option, the number of Shares in
respect of which the Option is being exercised (the "Exercised Shares"), and
such other representations and agreements as may be required by the Company
pursuant to the provisions of the Plan. The Exercise Notice shall be completed
by the Optionee and delivered to the Chief Financial Officer of the Company. The
Exercise Notice shall be accompanied by payment of the aggregate Exercise Price
as to all Exercised Shares. This Option shall be deemed to be exercised upon
receipt by the Company of such fully executed Exercise Notice accompanied by
such aggregate Exercise Price.

          No Shares shall be issued pursuant to the exercise of this Option
unless such issuance and exercise complies with Applicable Laws. Assuming such
compliance, for income tax purposes the Exercised Shares shall be considered
transferred to the Optionee on the date the Option is exercised with respect to
such Exercised Shares.




                                      -2-
<PAGE>   116

     3.   Vesting Acceleration on Change in Control.

          (a) In the event Optionee's employment is terminated without "Cause"
or voluntarily as a result of a "Constructive Termination" following a "Change
in Control," the Optionee's rights to purchase stock under this Option Agreement
with the Company shall be automatically vested to the extent that reflects an
additional twenty-four (24) months of vesting from the date of termination or
such longer period than twenty-four (24) months for which accelerated vesting
may be granted without incurring Federal excise tax imposed pursuant to Section
4996 of the Internal Revenue Code (or without increasing any such excise tax
otherwise payable without regard to such additional vesting), and provided
Optionee shall receive acceleration of less options than twenty-four (24) months
if Optionee would receive a greater after tax benefit as a result of any such
excise tax than if Optionee received acceleration of the full twenty-four (24)
months. Optionee shall be responsible for payment of any such excise tax.
Optionee shall have six (6) months from the date of termination of employment in
which to exercise any non-qualified stock option and three (3) months from the
date of termination of employment to exercise any incentive stock option.

          (b) "Cause" shall mean the termination of employment of Optionee shall
have taken place as a result of (i) Optionee's continued failure to
substantially perform his principal duties (other than as a result of
Disability) after thirty (30) days' written notice from the Company specifying
the nature of Optionee's failure and demanding that such failure be remedied;
(ii) Optionee's material and continuing breach of his obligations to the Company
after thirty (30) days' written notice from the Company specifying the nature of
Optionee's breach and demanding that such breach be remedied (unless such breach
by its nature cannot be cured, in which case notice and an opportunity to cure
shall not be required); (iii) Optionee's being convicted of a felony or (iv) act
or acts of dishonesty undertaken by Optionee and intended to result in
substantial gain or personal enrichment of Optionee at the expense of the
Company.

          (c)  "Change in Control" shall mean the occurrence of any of the
following events:

               (i) The shareholders of the Company approve a merger or
consolidation of the Company with any other corporation or entity, other than a
merger or consolidation which would result in the voting securities of the
Company outstanding immediately prior thereto continuing to represent (either by
remaining outstanding or by being converted into voting securities of the
surviving entity) at least fifty percent (50%) of the total voting power
represented by the voting securities of the Company or such surviving entity or
such surviving entity's parent outstanding immediately after such merger or
consolidation, or the shareholders of the Company approve a plan of complete
liquidation of the Company or an agreement for the sale or disposition by the
Company of all or substantially all the Company's assets, except a sale to an
entity of which at least fifty percent (50%) of the total voting power
represented by the voting securities of such entity are held by stockholders of
the Company at the time of such sale.

               (ii) The acquisition by any Person as Beneficial Owner (as such
terms are defined in the Securities Exchange Act of 1934, as amended), directly
or indirectly, of securities of 




                                      -3-
<PAGE>   117

the Company representing fifty percent (50%) or more of the total voting power
represented by the Company's then outstanding voting securities.

               (iii) A majority of the Board of Directors of the Company in
office at the beginning of any thirty-six (36) month period is replaced during
the course of such thirty-six (36) month period (other than by voluntary
resignation of individual directors in the ordinary course of business) and such
replacement was not initiated by the Board of Directors of the Company as
constituted at the beginning of such thirty-six (36) month period and as changed
during such period to add directors approved by the incumbent Board of
Directors.

          (d) "Constructive Termination" shall mean (i) a material reduction in
Optionee's salary, title, bonus opportunity or benefits not agreed to by
Optionee (except in connection with a decrease to be applied because the
Company's performance has decreased and which is also applied to other officers
or employees at Optionee's level, as applicable, and excluding the substitution
of substantially equivalent compensation and benefits) or (ii) a significant
reduction in Optionee's responsibilities not agreed to by Optionee.

          (e) "Disability" shall mean that the Optionee, at the time notice is
given, has been unable to perform his duties for a period of not less than
ninety (90) days consecutively as the result of his incapacity due to physical
or mental illness. In the event that the Optionee resumes the performance of
substantially all of his duties hereunder before the termination of his
employment becomes effective, the notice of termination shall automatically be
deemed to have been revoked.

     4.   Method of Payment. Payment of the aggregate Exercise Price shall be by
any of the following, or a combination thereof, at the election of the Optionee:

          (a) cash; or

          (b) check.

     5.   Non-Transferability of Option. This Option may not be transferred in 
any manner otherwise than by will or by the laws of descent or distribution and
may be exercised during the lifetime of Optionee only by the Optionee. The terms
of the Plan and this Option Agreement shall be binding upon the executors,
administrators, heirs, successors and assigns of the Optionee.

     6. Term of Option. This Option may be exercised only within the term set
out in the Notice of Grant, and may be exercised during such term only in
accordance with the Plan and the terms of this Option Agreement.

     7. Tax Consequences. Some of the federal tax consequences relating to this
Option, as of the date of this Option, are set forth below. THIS SUMMARY IS
NECESSARILY INCOMPLETE, AND THE TAX LAWS AND REGULATIONS ARE SUBJECT TO CHANGE.
THE OPTIONEE SHOULD CONSULT A TAX ADVISER BEFORE EXERCISING THIS OPTION OR
DISPOSING OF THE SHARES. 





                                      -4-
<PAGE>   118

          (a)  Exercising the Option.

               (i) Nonstatutory Stock Option. The Optionee may incur regular
federal income tax liability upon exercise of a NSO. The Optionee will be
treated as having received compensation income (taxable at ordinary income tax
rates) equal to the excess, if any, of the Fair Market Value of the Exercised
Shares on the date of exercise over their aggregate Exercise Price. If the
Optionee is an Employee or a former Employee, the Company will be required to
withhold from his or her compensation or collect from Optionee and pay to the
applicable taxing authorities an amount in cash equal to a percentage of this
compensation income at the time of exercise, and may refuse to honor the
exercise and refuse to deliver Shares if such withholding amounts are not
delivered at the time of exercise.

               (ii) Incentive Stock Option. If this Option qualifies as an ISO,
the Optionee will have no regular federal income tax liability upon its
exercise, although the excess, if any, of the Fair Market Value of the Exercised
Shares on the date of exercise over their aggregate Exercise Price will be
treated as an adjustment to alternative minimum taxable income for federal tax
purposes and may subject the Optionee to alternative minimum tax in the year of
exercise. In the event that the Optionee ceases to be an Employee but remains a
Service Provider, any Incentive Stock Option of the Optionee that remains
unexercised shall cease to qualify as an Incentive Stock Option and will be
treated for tax purposes as a Nonstatutory Stock Option on the date three (3)
months and one (1) day following such change of status.

          (b)  Disposition of Shares.

               (i) NSO. If the Optionee holds NSO Shares for at least one year,
any gain realized on disposition of the Shares will be treated as long-term
capital gain for federal income tax purposes.

               (ii) ISO. If the Optionee holds ISO Shares for at least one year
after exercise and two years after the grant date, any gain realized on
disposition of the Shares will be treated as long-term capital gain for federal
income tax purposes. If the Optionee disposes of ISO Shares within one year
after exercise or two years after the grant date, any gain realized on such
disposition will be treated as compensation income (taxable at ordinary income
rates) to the extent of the excess, if any, of the lesser of (A) the difference
between the Fair Market Value of the Shares acquired on the date of exercise and
the aggregate Exercise Price, or (B) the difference between the sale price of
such Shares and the aggregate Exercise Price. Any additional gain will be taxed
as capital gain, short-term or long-term depending on the period that the ISO
Shares were held.

          (c)  Notice of Disqualifying Disposition of ISO Shares. If the 
Optionee sells or otherwise disposes of any of the Shares acquired pursuant to
an ISO on or before the later of (i) two years after the grant date, or (ii) one
year after the exercise date, the Optionee shall immediately notify the Company
in writing of such disposition. The Optionee agrees that he or she may be
subject to income tax withholding by the Company on the compensation income
recognized from




                                      -5-
<PAGE>   119

such early disposition of ISO Shares by payment in cash or out of the current
earnings paid to the Optionee.

     8.   Entire Agreement; Governing Law. The Plan is incorporated herein by
reference. The Plan and this Option Agreement constitute the entire agreement of
the parties with respect to the subject matter hereof and supersede in their
entirety all prior undertakings and agreements of the Company and Optionee with
respect to the subject matter hereof, and may not be modified adversely to the
Optionee's interest except by means of a writing signed by the Company and
Optionee. This agreement is governed by the internal substantive laws, but not
the choice of law rules, of California.

     9.   NO GUARANTEE OF CONTINUED SERVICE. OPTIONEE ACKNOWLEDGES AND AGREES 
THAT THE VESTING OF SHARES PURSUANT TO THE VESTING SCHEDULE HEREOF IS EARNED
ONLY BY CONTINUING AS A SERVICE PROVIDER AT THE WILL OF THE COMPANY (AND NOT
THROUGH THE ACT OF BEING HIRED, BEING GRANTED AN OPTION OR PURCHASING SHARES
HEREUNDER). OPTIONEE FURTHER ACKNOWLEDGES AND AGREES THAT THIS AGREEMENT, THE
TRANSACTIONS CONTEMPLATED HEREUNDER AND THE VESTING SCHEDULE SET FORTH HEREIN DO
NOT CONSTITUTE AN EXPRESS OR IMPLIED PROMISE OF CONTINUED ENGAGEMENT AS A
SERVICE PROVIDER FOR THE VESTING PERIOD, FOR ANY PERIOD, OR AT ALL, AND SHALL
NOT INTERFERE WITH OPTIONEE'S RIGHT OR THE COMPANY'S RIGHT TO TERMINATE
OPTIONEE'S RELATIONSHIP AS A SERVICE PROVIDER AT ANY TIME, WITH OR WITHOUT
CAUSE.

     By your signature and the signature of the Company's representative below,
you and the Company agree that this Option is granted under and governed by the
terms and conditions of the Plan and this Option Agreement. Optionee has
reviewed the Plan and this Option Agreement in their entirety, has had an
opportunity to obtain the advice of counsel prior to executing this Option
Agreement and fully understands all provisions of the Plan and Option Agreement.
Optionee hereby agrees to accept as binding, conclusive and final all decisions
or interpretations of the Administrator upon any questions relating to the Plan
and Option Agreement. Optionee further agrees to notify the Company upon any
change in the residence address indicated below.





                                      -6-
<PAGE>   120




OPTIONEE:                                          ANERGEN, INC.


- -------------------------------------   ----------------------------------------
Signature                               By

- -------------------------------------   ----------------------------------------
Print Name                              Title

- -------------------------------------
Residence Address

- -------------------------------------






                                      -7-
<PAGE>   121


                                CONSENT OF SPOUSE


     The undersigned spouse of Optionee has read and hereby approves the terms
and conditions of the Plan and this Option Agreement. In consideration of the
Company's granting his or her spouse the right to purchase Shares as set forth
in the Plan and this Option Agreement, the undersigned hereby agrees to be
irrevocably bound by the terms and conditions of the Plan and this Option
Agreement and further agrees that any community property interest shall be
similarly bound. The undersigned hereby appoints the undersigned's spouse as
attorney-in-fact for the undersigned with respect to any amendment or exercise
of rights under the Plan or this Option Agreement.



                                        ----------------------------------------
                                        Spouse of Optionee






                                      -8-
<PAGE>   122



                                    EXHIBIT A

                                  ANERGEN, INC.

                                 1996 STOCK PLAN

                                 EXERCISE NOTICE


Anergen, Inc.
301 Penobscot Drive
Redwood City, CA 94063
Attention:  Chief Financial Officer


     1. Exercise of Option. Effective as of today, ________________, 199__, the
undersigned ("Purchaser") hereby elects to purchase ______________ shares (the
"Shares") of the Common Stock of Anergen, Inc. (the "Company") under and
pursuant to the 1996 Stock Plan (the "Plan") and the Stock Option Agreement
dated ___, 19___ (the "Option Agreement"). The purchase price for the Shares
shall be $ ______, as required by the Option Agreement.

     2. Delivery of Payment. Purchaser herewith delivers to the Company the full
purchase price for the Shares.

     3. Representations of Purchaser. Purchaser acknowledges that Purchaser has
received, read and understood the Plan and the Option Agreement and agrees to
abide by and be bound by their terms and conditions.

     4. Rights as Shareholder. Until the issuance (as evidenced by the
appropriate entry on the books of the Company or of a duly authorized transfer
agent of the Company) of the Shares, no right to vote or receive dividends or
any other rights as a shareholder shall exist with respect to the Optioned
Stock, notwithstanding the exercise of the Option. The Shares so acquired shall
be issued to the Optionee as soon as practicable after exercise of the Option.
No adjustment will be made for a dividend or other right for which the record
date is prior to the date of issuance, except as provided in Section 13 of the
Plan.

     5. Tax Consultation. Purchaser understands that Purchaser may suffer
adverse tax consequences as a result of Purchaser's purchase or disposition of
the Shares. Purchaser represents that Purchaser has consulted with any tax
consultants Purchaser deems advisable in connection with the purchase or
disposition of the Shares and that Purchaser is not relying on the Company for
any tax advice.

     6. Entire Agreement; Governing Law. The Plan and Option Agreement are
incorporated herein by reference. This Agreement, the Plan and the Option
Agreement constitute the entire 




                                      -1-
<PAGE>   123

agreement of the parties with respect to the subject matter hereof and supersede
in their entirety all prior undertakings and agreements of the Company and
Purchaser with respect to the subject matter hereof, and may not be modified
adversely to the Purchaser's interest except by means of a writing signed by the
Company and Purchaser. This agreement is governed by the internal substantive
laws, but not the choice of law rules, of California.


Submitted by:                           Accepted by:

PURCHASER:                              ANERGEN, INC.


- -------------------------------------   ----------------------------------------
Signature                               By

- -------------------------------------   ----------------------------------------
Print Name                              Its


Address:                                Address:

                                        301 Penobscot Drive
- -------------------------------------   Redwood City, CA 94063

- -------------------------------------   ----------------------------------------
                                        Date Received





                                      -2-
<PAGE>   124
PROXY

                                 ANERGEN, INC.

              PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                      1998 ANNUAL MEETING OF SHAREHOLDERS

     The undersigned shareholder(s) of Anergen, Inc., a California corporation,
hereby acknowledges receipt of the Notice of Annual Meeting of Shareholders and
Proxy Statement for the 1998 Annual Meeting of Shareholders to be held on April
29, 1998, and hereby appoints Barry M. Sherman, M.D. and David V. Smith, and
each of them, as Proxies, with power and substitution, to represent the
undersigned at such meeting and at any adjournments thereof, and to vote all
shares of Common Stock which the undersigned is entitled to vote, as designated
below. 

     In their discretion the Proxies are authorized to vote upon such other
business as may properly come before the meeting. 

        UNLESS A CONTRARY DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED FOR
THE ELECTION OF DIRECTORS AS SET FORTH IN PROPOSAL 1, FOR APPROVAL OF THE
AMENDMENT TO THE COMPANY'S 1991 EMPLOYEE STOCK PURCHASE PLAN AS SET FORTH IN
PROPOSAL 2, FOR APPROVAL OF THE AMENDMENT TO THE 1996 STOCK PLAN AS SET FORTH
IN PROPOSAL 3, FOR APPROVAL OF THE REINCORPORATION OF THE COMPANY INTO THE
STATE OF DELAWARE AS SET FORTH IN PROPOSAL 4, FOR APPROVAL OF THE FORM OF
INDEMNIFICATION AGREEMENT TO BE EXECUTED IF THE REINCORPORATION IS APPROVED AS
SET FORTH IN PROPOSAL 5, TO APPROVE A REVERSE STOCK SPLIT AS SET FORTH IN
PROPOSAL 6, TO APPROVE AN AMENDMENT TO THE AMENDED AND RESTATED ARTICLES OF
INCORPORATION INCREASING THE AUTHORIZED NUMBER OF SHARES OF COMMON STOCK OF THE
COMPANY TO 60,000,000 SHARES AS SET FORTH IN PROPOSAL 7, AND FOR CONFIRMATION
OF ERNST & YOUNG LLP AS AUDITORS AS SET FORTH IN PROPOSAL 8. 

COMMENTS/ADDRESS CHANGE: PLEASE MARK COMMENT/ADDRESS BOX ON REVERSE SIDE




(Continued, and to be signed on the other side)
<PAGE>   125
                                                 Please mark your votes
                                                 as indicated in this
                                                 example                [X]


THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" EACH OF THE FOLLOWING PROPOSALS.

                                                                    WITHHOLD
                                                        FOR          FOR ALL

1.  To elect directors and serve for the ensuing        [ ]            [ ]
    year and until their successors are elected.

    If you wish to withhold authority to vote for
    any individual nominee, strike a line through
    that nominee's name in the list below.

    Barry M. Sherman, M.D., Bruce L.A. Carter, Ph.D., Nicholas J. Lowcock,
    Harden M. McConnell, Ph.D., Henry H. Penner, Jr., James E. Thomas, and
    Nicole Vitullo

                                                     FOR     AGAINST     ABSTAIN

2.  To approve an amendment to the 1991 Employee     [ ]       [ ]         [ ]
    Stock Purchase Plan increasing the number
    of authorized shares by 500,000.

3.  To approve an amendment to the 1996 Stock        [ ]       [ ]         [ ]
    Plan increasing the number of authorized
    shares by 1,000,000.

4.  To approve the reincorporation of the            [ ]       [ ]         [ ]
    Company into the State of Delaware.

5.  To approve the form of indemnification           [ ]       [ ]         [ ]
    agreement to be executed if the
    reincorporation is approved.

6.  To approve an amendment to the Amended and       [ ]       [ ]         [ ]
    Restated Articles of Incorporation to effect 
    a reverse split of the Company's Common Stock.

7.  To approve an amendment to the Company's         [ ]       [ ]         [ ]
    Amended and Restated Articles of 
    Incorporation increasing the authorized 
    number of shares of Common Stock to 
    60,000,000 shares.

8.  To confirm the appointment of Ernst &            [ ]       [ ]         [ ]
    Young LLP as independent auditors of the
    Company for the 1998 fiscal year.

Please sign exactly as name appears hereon. If the stock is registered in the
names of two or more persons, each person should sign. Executors,
administrators, trustees, guardians and attorneys-in-fact should add their
titles. If signer is a corporation, please give the full corporate name and
have a duly authorized officer sign, stating title. If signer is a partnership,
please sign in the partnership name by the authorized person.

I PLAN TO ATTEND THE MEETING     [ ]        COMMENTS/ADDRESS CHANGE          [ ]
                                            Please mark this box if you
                                            have written comments/address 
                                            change on the reverse side


Signature(s)                                                Date
            --------------------------------------------         --------------

Note: Please vote, date and promptly return this proxy in the enclosed envelope
      which is postage prepaid if mailed in the United States.


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