PHARMACEUTICAL RESOURCES INC
PRE 14A, 1998-04-21
PHARMACEUTICAL PREPARATIONS
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                            SCHEDULE 14A INFORMATION

  Proxy Statement Pursuant to 14(a) of the Securities and Exchange Act of 1934

                                (Amendment No. )

Filed by the Registrant [X]
Filed by a Party other than the Registrant [   ]

Check the appropriate box:

[ X ]    Preliminary Proxy Statement       [   ]   Confidential, for Use of the
                                                   Commission Only (as permitted
                                                   by Rule 14a-6(e)(2))

[   ]    Definitive Proxy Statement
[   ]    Definitive Additional Materials
[   ]    Soliciting Material Pursuant to ss.240.14a-11(c) or ss.240.14a-12


                         Pharmaceutical Resources, Inc.
     -------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)


     -------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[ X ]    No fee required.

[   ]    Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11

         1) Title of each class of securities to which transaction applies:

            -------------------------------------------------------------------

         2) Aggregate number of securities to which transaction applies:

            -------------------------------------------------------------------

         3) Per unit price or other underlying  value of transaction  computed
            pursuant to Exchange  Act Rule 0-11 (set forth the amount on which
            the filing fee is calculated and state how it was determined):

            -------------------------------------------------------------------

         4) Proposed maximum aggregate value of transaction:

            -------------------------------------------------------------------

         5) Total fee paid:

            -------------------------------------------------------------------
<PAGE>


[   ]    Fee paid previously with preliminary materials.

[   ]    Check box if any part of the fee is an offset as provided by Exchange

         Act Rule  0-11(a)(2)  and identify the filing for which the offsetting
         fee was paid previously.  Identify the previous filing by registration
         statement number, or the Form or Schedule and the date of its filing.

         1) Amount Previously Paid:

            -------------------------------------------------------------------

         2) Form, Schedule or Registration Statement No.:

            -------------------------------------------------------------------

         3) Filing Party:

            -------------------------------------------------------------------

         4) Date Filed:

            -------------------------------------------------------------------


<PAGE>

                         PRELIMINARY COPY-FOR SEC REVIEW

                         PHARMACEUTICAL RESOURCES, INC.

                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                           To Be Held On June __, 1998

TO THE SHAREHOLDERS:

     The 1998 Annual Meeting of Shareholders of Pharmaceutical  Resources,  Inc.
(the  "Company")  will be held on June ___,  1998,  at  Holiday  Inn-Suffern,  3
Executive  Boulevard,  Suffern,  New York at 10:00  a.m.,  local  time,  for the
following purposes:

     I.   To elect seven members of the Company's Board of Directors;

     II. To approve the sale of 10,400,000  shares of the Company's Common Stock
to Lipha Americas, Inc. at a price of $2.00 per share and the grant and issuance
of stock  options to Merck  KGaA,  Darmstadt,  Germany,  and  Genpharm  Inc.  to
purchase an aggregate of 1,171,040  shares of the  Company's  Common Stock at an
exercise  price of $2.00 per share,  as further  described  in the  accompanying
Proxy Statement;

     III. To approve an amendment to the Company's  Certificate of Incorporation
to increase the authorized  number of shares of Common Stock from  60,000,000 to
90,000,000;

     IV. To approve and adopt the Company's  1997  Directors  Stock Option Plan;
and

     V. To transact such other  business as may properly come before the meeting
and any adjournment(s) thereof.

     The Board of Directors has fixed the close of business on April 30, 1998 as
the record date for the determination of shareholders entitled to notice of, and
to vote at,  the 1998  Annual  Meeting of  Shareholders  (the  "Meeting").  Only
shareholders of record at the close of business on such date will be entitled to
notice of, and to vote at, the Meeting and any adjournment(s) thereof.

                                      By Order of the Board of Directors


                                      Dennis J. O'Connor
                                      Secretary

May__, 1998



   YOU ARE URGED TO COMPLETE,  DATE AND SIGN THE ENCLOSED  PROXY CARD AND RETURN
   IT PROMPTLY IN THE POSTAGE PREPAID ENVELOPE WHICH HAS BEEN PROVIDED,  WHETHER
   OR NOT YOU PLAN TO ATTEND THE MEETING IN PERSON.  THE PROXY MAY BE REVOKED BY
   YOU AT ANY TIME PRIOR TO EXERCISE,  AND IF YOU ARE PRESENT AT THE MEETING YOU
   MAY, IF YOU WISH,  REVOKE YOUR PROXY AT THAT TIME AND EXERCISE  YOUR RIGHT TO
   VOTE YOUR SHARES PERSONALLY.

<PAGE>

                         PRELIMINARY COPY-FOR SEC REVIEW

                                 PROXY STATEMENT

                         PHARMACEUTICAL RESOURCES, INC.

                               One Ram Ridge Road
                          Spring Valley, New York 10977

                         ANNUAL MEETING OF SHAREHOLDERS
                           To Be Held On June __, 1998

                               GENERAL INFORMATION


     This Proxy Statement is being  furnished to shareholders of  Pharmaceutical
Resources,  Inc. (the "Company"),  a New Jersey corporation,  in connection with
the solicitation by the Company's Board of Directors (the "Board") of proxies to
be voted at the 1998 Annual Meeting of Shareholders (the "Meeting"),  and at any
adjournment(s) thereof, for the purposes set forth in the accompanying Notice of
Annual Meeting of  Shareholders.  The Meeting is to be held on June __, 1998, at
Holiday  Inn-Suffern,  3 Executive  Boulevard,  Suffern, New York at 10:00 a.m.,
local time.

     The principal executive offices of the Company are located at One Ram Ridge
Road, Spring Valley, New York 10977, and its telephone number is (914) 425-7100.
The  accompanying  proxy card and this Proxy Statement are being  transmitted to
shareholders of the Company on or about May __, 1998.

Recent Developments
- -------------------

     The Company has  recently  agreed to enter into a strategic  alliance  with
Merck KGaA,  Darmstadt,  Germany, a  Kommanditgesellschaft  auf Aktien organized
under  the  laws of  Germany  ("Merck  KGaA").  Merck  KGaA is a  multi-national
pharmaceutical,  laboratory and chemical  company.  Pursuant to a Stock Purchase
Agreement,  dated March 25, 1998 (the "Stock Purchase  Agreement"),  between the
Company and Lipha  Americas,  Inc., a Delaware  corporation  and a subsidiary of
Merck ("Lipha"),  the Company agreed to sell 10,400,000  shares of the Company's
common stock, par value $.01 per share ("Common  Stock"),  to Lipha at $2.00 per
share.  Also, the Company agreed to issue options to purchase up to an aggregate
of 1,171,040  shares of Common Stock at an exercise  price of $2.00 per share to
Merck KGaA and Genpharm Inc., a Canadian  corporation  and a subsidiary of Merck
KGaA  ("Genpharm"),  in  exchange  for  certain  services  to be provided to the
Company.  In  connection  with the Stock  Purchase  Agreement,  the Company also
obtained from Genpharm  exclusive  distribution  rights in the United States for
approximately 40 generic pharmaceutical products currently being developed, some
of which have obtained  governmental approval and others which have been or will
be  submitted  for  approval.  Such  transactions  are referred to in this Proxy
Statement as the "Proposed  Transaction."  The  completion  of the  transactions
contemplated by the Stock Purchase  Agreement is subject to certain  conditions,
including approval by the shareholders at the Meeting of Proposals I, II and III
as further  described in this Proxy  Statement.  These three Proposals relate to
the  transactions  contemplated  by the Stock  Purchase  Agreement  and  certain
related  agreements.  Shareholders are urged to carefully review the description
of the transactions  contemplated by the Stock Purchase  Agreement in this Proxy
Statement under Proposals I, II and III below. The Board unanimously  recommends
that the Company's shareholders vote in favor of such Proposals.


Solicitation and Revocation
- ---------------------------

     The  accompanying  proxy  card is being  solicited  by and on behalf of the
Board.  The  solicitation  of proxies will be made  principally  by mail and, in
addition, may be made by directors, officers and employees of the Company

                                       1
<PAGE>

personally,  or by telephone  or  telegraph,  without  extra  compensation.  The
Company  has  also  retained  Georgeson  &  Company  Inc.  to  assist  it in the
solicitation of proxies.  Brokers,  nominees and fiduciaries  will be reimbursed
for their  out-of-pocket  and  clerical  expenses  in  transmitting  proxies and
related material to beneficial  owners.  The costs of soliciting proxies will be
borne by the  Company.  It is  estimated  that such costs will be  approximately
$8,000.

     The  presence at the  Meeting,  in person or by proxy,  of the holders of a
majority of the outstanding shares of Common Stock will constitute a quorum. The
accompanying  proxy card is intended to permit a shareholder  of record on April
30,  1998  to vote at the  Meeting  on the  Proposals  described  in this  Proxy
Statement, whether or not the shareholder attends the Meeting in person. Persons
who acquire  shares of record after the close of business on April 30, 1998 will
not be  entitled to vote such shares at the Meeting by proxy or by voting at the
Meeting in person unless properly authorized by the record holder of such shares
as of such date.

     The persons named in the  accompanying  proxy card have been  designated as
proxies by the Board.  Shares  represented by properly executed proxies received
by the Company will be voted at the Meeting in the manner specified  therein or,
if no  specification  is made, will be voted (i) "FOR" the election of the seven
nominees for director named herein,  (ii) "FOR" the sale of 10,400,000 shares of
the  Common  Stock to Lipha at a price of $2.00  per  share  and the  grant  and
issuance of stock options to Merck KGaA and Genpharm to purchase an aggregate of
1,171,040  shares of Common  Stock at an exercise  price of $2.00 per share,  as
further  described  in this Proxy  Statement,  (iii)  "FOR" the  approval  of an
amendment  to  the  Company's  Certificate  of  Incorporation  to  increase  the
authorized number of shares of Common Stock from 60,000,000 to 90,000,000,  (iv)
"FOR" the approval and adoption of the 1997 Directors Stock Option Plan, and (v)
at the  discretion  of the proxy holders in respect of such other  business,  if
any, as may properly be brought before the Meeting.

     The election of directors will require an  affirmative  vote of a plurality
of the votes cast, approval of Proposals II and III will require the affirmative
vote of the holders of a majority of the outstanding  shares of Common Stock and
approval of any other  proposal  (including  Proposal  IV) at the Meeting  will,
subject to applicable  law,  require the  affirmative  vote of a majority of the
votes  cast in  person or by proxy at the  Meeting.  Abstentions  and  shares of
record  held by a broker  or  nominee  ("Broker  Shares")  that are voted on any
matter will be included in determining the existence of a quorum.  Broker Shares
that are not  voted  on any  matter  will not be  included  in  determining  the
existence  of a quorum.  Abstentions  and  Broker  Shares  that are not voted in
respect of  Proposals I and/or IV will not be counted in  determining  the votes
cast in  respect of the  respective  Proposal.  Thus,  neither  abstentions  nor
non-voted  Broker  Shares will have an effect on the outcome of the  election of
the seven  nominees for  directors,  which requires only that a plurality of the
votes cast be in favor of each  nominee,  or the adoption of the 1997  Directors
Stock Option Plan, which requires only the affirmative vote of a majority of the
votes  cast in  person  or by proxy at the  Meeting.  However,  abstentions  and
non-voted  Broker  Shares  will have the effect of a vote  against  approval  of
Proposals II and III, each of which requires the affirmative vote of the holders
of a majority of the outstanding shares of Common Stock.

     Any proxy conferred by a shareholder  pursuant to this  solicitation may be
revoked  by such  shareholder  at any time  before it is  exercised  by  written
notification  delivered to the Secretary of the Company,  by voting in person at
the Meeting,  or by duly executing and delivering  another proxy bearing a later
date.  Attendance by a shareholder at the Meeting does not alone serve to revoke
the proxy.

                  VOTING SECURITIES AND PRINCIPAL SHAREHOLDERS

Outstanding Shares
- ------------------

     The Board has fixed the close of  business  on April 30, 1998 as the record
date (the "Record Date") for the  determination  of  shareholders of the Company
who are entitled to receive notice of, and to vote at, the Meeting. An aggregate
of [18,886,098] shares of Common Stock were outstanding at the close of business
on the Record Date. Each share of Common Stock outstanding on the Record Date is
entitled to one vote on each matter to be voted upon at the

                                        2

<PAGE>


Meeting.  The Company has no other class of voting securities entitled to vote
at the Meeting, and the Company's shareholders do not have cumulative voting 
rights.


Ownership of Voting Securities
- ------------------------------

     The following  table sets forth,  as of the close of business on the Record
Date,  the  beneficial  ownership  of the Common  Stock by (i) each person known
(based  solely  upon  a  review  of  Schedule  13Ds)  to the  Company  to be the
beneficial owner of more than 5% of the Common Stock, (ii) each current director
and  nominee  for  election  as a  director  of the  Company,  (iii)  the  Named
Executives,  as defined in the "--Executive  Compensation" section of this Proxy
Statement, and (iv) all directors and current executive officers of the Company,
as a group  (based  solely  in  respect  of  clauses  (ii),  (iii) and (iv) upon
information  furnished by such  persons).  Under the rules of the Securities and
Exchange  Commission,  a person is deemed to be a beneficial  owner of an equity
security  if such person has or shares the power to vote or direct the voting of
such  security or the power to dispose of or to direct the  disposition  of such
security.  In general,  a person is also deemed to be a beneficial  owner of any
equity  securities  of which that  person  has the right to  acquire  beneficial
ownership within 60 days. Accordingly,  more than one person may be deemed to be
a beneficial owner of the same securities.

<TABLE>
<CAPTION>

                                                         Without Giving Effect to    If Proposed Transaction
                                                         the Proposed Transaction          is Approved
                                                         ------------------------    -----------------------
                                                                      Percentage
                                                           Amount of      of                   Percentage of
            Name and Address of Beneficial Owner(6)          Common     Common     Amount of       Common
            ---------------------------------------          Stock       Stock    Common Stock     Stock
                                                          --------------------------------------------------
<S>                                                       <C>            <C>      <C>               <C>  
Merck KGaA(1).........................................      249,700       1.30    12,462,972        42.20
Clal Pharmaceutical Industries Ltd.(2)................    2,313,272      12.23       500,000         1.71
Kenneth I. Sawyer(3)(4)(5)............................      156,900          *       156,900            *
Melvin H. Van Woert, M.D.(3)(4).......................       71,650          *        71,650            *
Andrew Maguire, Ph.D.(3)(4)...........................       38,800          *        38,800            *
H. Spencer Matthews(3)(4).............................       38,500          *        38,500            *
Mark Auerbach(3)(4)(5)................................       49,500          *        49,500            *
Robin O. Motz, M.D., Ph.D.(3)(4)......................       44,500          *        44,500            *
Dennis J. O'Connor(3).................................       24,118          *        24,118            *
Stephen A. Ollendorff(5)..............................          475          *           475            *
Rudi D. Neirinckx, Ph.D.(5)...........................    [       ]          *      [      ]            *
[Merck nominee 2](5)...................................   [       ]          *      [      ]            *
[Merck nominee 3](5)...................................   [       ]          *      [      ]            *
[Merck nominee 4](5)...................................   [       ]          *      [      ]            *
All directors and current executive officers                              2.22       423,968         1.44
as a group (seven persons) (3)........................      423,968
</TABLE>

*    Less than 1%.
(1)  The  business  address of Merck KGaA is  Frankfurter  Strasse  250,  64271,
     Darmstadt,  Germany.  Includes  249,700 shares of Common Stock which may be
     acquired by Genpharm, a subsidiary of Merck KGaA, upon exercise of warrants
     exercisable  on or prior to June 29,  1998.  Warrants  for  99,700  of such
     shares have an exercise  price of $6.00 per share and  warrants for 150,000
     of such shares have an exercise price of $10.00 per share. Amount under "If
     Proposed Transaction is Approved" column also includes 10,400,000 shares of
     Common Stock,  beneficial  ownership of which is to be acquired by Lipha, a
     subsidiary of Merck KGaA, if the Proposed  Transaction is  consummated  and
     1,813,272  shares  of  Common  Stock  to be  sold  by  Clal  Pharmaceutical
     Industries  Ltd.  ("Clal") to Merck KGaA (or its  designee)  at the time of
     such consummation. Does not include an additional

                                        3

<PAGE>

     1,171,040  shares  which may be  acquired  upon  exercise  of options to be
     granted to Merck KGaA and Genpharm upon  consummation of the Stock Purchase
     Agreement.  Such options are not  exercisable on or prior to June 29, 1998.
     See "Proposal II-Approval of Stock Sale and Option Issuance."

(2)  The business  address of Clal is Clal House,  5 Druyanov  Street,  Tel Aviv
     63143,  Israel.  Amount under "If Proposed  Transaction is Approved" column
     gives effect to sale of  1,813,272  shares of Common Stock by Clal to Merck
     KGaA upon  consummation of the Stock Purchase  Agreement.  Includes 500,000
     shares of Common Stock which, under certain circumstances,  may be acquired
     by Merck KGaA after June 29, 1998.  See "Proposal II Approval of Stock Sale
     and Option Issuance."

(3)  Includes  shares of Common Stock which may be acquired upon the exercise of
     options  which  are  exercisable  on or prior to June 29,  1998  under  the
     Company's stock option plans as follows:  Dr. Van Woert, 69,000 shares; Mr.
     Maguire, 36,000 shares; Mr. Matthews,  36,000 shares; Mr. Auerbach,  47,000
     shares; Dr. Motz, 42,000 shares; and Mr. O'Connor,  22,500 shares. Does not
     reflect  agreements of the current executive  officers and directors of the
     Company in connection  with the Proposed  Transaction  not to exercise such
     stock options for certain  periods of time. See "Proposal II -- Approval of
     Stock Sale and Option  Issuance." Does not include options to be granted to
     current directors under the 1997 Directors Stock Option Plan if Proposal IV
     is approved by the shareholders at the Meeting. See "Proposal  IV--Approval
     and Adoption of 1997 Directors Stock Option Plan."

(4)  A current director of the Company.

(5)  A  nominee  for  election  as a  director  of the  Company.  See  "Proposal
     I-Election of Directors." Dr. Neirinckx will become the President and Chief
     Operating  Officer  of the  Company  upon  the  consummation  of the  Stock
     Purchase Agreement.

(6)  The business  address of each director,  executive  officer and nominee for
     election as a director of the Company,  for the purposes hereof, is in care
     of Pharmaceutical  Resources,  Inc., One Ram Ridge Road, Spring Valley, New
     York 10977.


Voting Arrangements
- -------------------

     The Company and Clal entered into a Stock Purchase  Agreement,  dated March
25, 1995, as amended (the "Clal Stock  Purchase  Agreement"),  pursuant to which
Clal, on May 1, 1995,  purchased 2,027,272 shares of Common Stock. Clal acquired
100,000  additional  shares of Common  Stock in June  1996 from Mr.  Sawyer  and
acquired an additional  186,000  shares of Common Stock from the Company in July
1997 in connection with an amendment of the Clal Stock Purchase Agreement.  Clal
has  certain  rights  under the Clal  Stock  Purchase  Agreement  to  nominate a
director  to  the  Company's  Board  and  committees   thereof.   See  "Proposal
I--Election  of  Directors--Certain  Relationships  and  Related  Transactions."
Pursuant to an agreement among the Company, Merck KGaA and Clal, dated March 25,
1998 (the  "Clal  Sale  Agreement"),  Clal  agreed to vote all of its  shares of
Common  Stock for the  election of the seven  nominees for director set forth in
Proposal I and for the approval of Proposals II and III at the Meeting. Upon the
consummation of the Stock Purchase Agreement,  the Clal Stock Purchase Agreement
will terminate. See "Proposal II -- Approval of Stock Sale and Option Issuance."

     In accordance with the Stock Purchase  Agreement,  Mr. Sawyer has agreed to
vote all of his shares of Common  Stock for the  election of the seven  nominees
for  director  set forth in Proposal I and for the  approval of Proposals II and
III at the Meeting.  Pursuant to the Stock Purchase Agreement,  Lipha has agreed
with the Company to vote,  and to cause its  affiliates  to vote,  any shares of
Common Stock that they may own in favor of such Proposals at the Meeting.
See "Proposal II -- Approval of Stock Sale and Option Issuance."


                                        4

<PAGE>

                                   PROPOSAL I

                              ELECTION OF DIRECTORS

Directors
- ---------

     The Company's Certificate of Incorporation  provides that the Board will be
divided into three  classes,  with the term of office of one class expiring each
year. The maximum number of directors is set by the Company's By-laws at 15, and
the number of directors is presently set, by Board resolution, at six. The Class
I and Class III  directors  of the Company  have terms which expire in the years
2000 and 1999, respectively. The Class II directors have terms which expire this
year.  The current Class I directors are Mark Auerbach and H. Spencer  Matthews,
the current Class II directors are Andrew  Maguire and Melvin H. Van Woert,  and
the current Class III directors are Kenneth I. Sawyer and Robin O. Motz.

     In connection  with the Proposed  Transaction,  all current  directors will
resign as directors in their current  Class,  subject to and effective  upon the
consummation of the Stock Purchase Agreement.  The Board has, in connection with
the  Proposed  Transaction,  voted to increase the size of the Board from six to
seven,  subject to and effective  upon the  consummation  of the Stock  Purchase
Agreement.  The  following  persons have been  nominated  to become,  subject to
consummation  of the  Stock  Purchase  Agreement,  directors  in  the  following
Classes:  Class I directors  having  terms which  expire in 2000 and until their
successors have been duly elected and qualified - Rudi D.  Neirinckx,  Ph.D. and
[_______];  Class II directors having terms which expire in 2001 and until their
successors  have been duly  elected  and  qualified  - Kenneth I.  Sawyer,  Mark
Auerbach and Stephen A.  Ollendorff;  and Class III directors having terms which
expire in 1999 and until their  successors  have been duly elected and qualified
- -[_____]  and  [______].  In  connection  with the Proposed  Transaction,  Lipha
obtained the right to designate  the Class I and III nominees and the  Company's
current  Board  designated  the Class II nominees (the  "Company's  Designees").
Messrs.  Sawyer and Auerbach are currently  members of the Board,  and are being
nominated to become  directors of a different  Class than they currently are in.
The Nominating  Committee of the Board has nominated,  pursuant to the Company's
By-Laws and  Certificate  of  Incorporation,  each of the persons  designated by
Lipha and the current Board. In addition, the Company's Designees and Lipha have
agreed  to  jointly  designate  two of  the  directors  to  comprise  the  Audit
Committee.  See "Proposal II -- Approval of Stock Sale and Option Issuance-Stock
Purchase Agreement."

     Clal  presently  has the right to designate a director of the Board and its
committees.  However,  Clal  has  elected  not to  designate  any  nominees  for
director.  See  "--Certain  Relationships  and Related  Transactions."  Upon the
consummation  of  the  Stock  Purchase  Agreement,  Clal's  right  to  designate
directors  will  terminate.  See "Proposal  II-Approval of Stock Sale and Option
Issuance."

     Proxies in the  accompanying  form will be voted at the Meeting in favor of
the election of each of the nominees  listed on the  accompanying  form of proxy
card,  unless  authority  to do so is  withheld  as to a  specified  nominee  or
nominees  or all  nominees  as a group.  Proxies  cannot  be voted for a greater
number of persons than the number of nominees named therein. It is expected that
each of the  nominees  will be able to serve,  but if  before  the  election  it
develops  that any one or more of the  nominees  will be  unable to serve or for
good cause will not serve,  the  proxyholders  reserve the discretion to vote or
refrain from voting for a substitute  nominee or nominees.  Each of the nominees
has  consented  to serve as a director of the  Company  and to be named  herein.
Directors  will be elected by a  plurality  of the votes cast by the  holders of
shares who are present at the Meeting in person or by proxy.

     The  following  table sets forth certain  information  with respect to each
nominee  for  election  as a Class I,  Class II and  Class III  director  of the
Company at the Meeting and, for those nominees who are currently directors,  the
year each was first elected as a director:


                                        5

<PAGE>



                                                                           Year
                                                                        of First
Name                                                               Age  Election
- ----                                                               ---  --------
Class I
Rudi D. Neirinckx, Ph.D.......................................      [ ]    --
        [bio to come]

     [Additional nominee designated by Lipha to come]

Class II
Kenneth I Sawyer(1)(2)(3).....................................      52    1989
     Since  October  1990,  Chairman  of  the  Board  of the
     Company.   Since  October  1989,  President  and  Chief
     Executive  Officer of the Company.  From September 1989
     to October 1989,  Interim President and Chief Executive
     Officer of the  Company.  From August 1989 to September
     1989,  counsel to the Company.  From May 1989 to August
     1989,  an attorney in private  practice.  From prior to
     1987 to May 1989, Vice President and General Counsel of
     Orlove  Enterprises,  Inc.,  a company  engaged  in the
     manufacture  and  distribution  of  pharmaceutical  and
     other  products.  Director  of  Acorn  Venture  Capital
     Corporation,  a  publicly-traded  holding company.  Mr.
     Sawyer is presently a Class III director.

Mark Auerbach(4)(5)..........................................       59    1990
     Since June 1993,  the Senior Vice  President  and Chief
     Financial Officer of Central Lewmar L.P., a distributor
     of fine  papers.  From  August  1992 to  June  1993,  a
     partner of Marron  Capital L.P., an investment  banking
     firm. From July 1990 to August 1992,  President,  Chief
     Executive  Officer and  Director of Implant  Technology
     Inc., a manufacturer of artificial hips and knees.  Mr.
     Auerbach is presently a Class I director.

Stephen A. Ollendorff........................................      59      --
     Practicing  attorney for more than the past five years.
     Since December 1990, of counsel to Hertzog,  Calamari &
     Gleason.  Chief Executive Officer and director of Acorn
     Venture Capital Corporation for more than the past five
     years. Director of Computer Products, Inc., a designer,
     manufacturer and seller of power supplies.

Class III
     [Two nominees designated by Lipha to come]

- -----------------

(1) A member of the Strategic Planning Committee of the Board.

(2) A member of the Nominating Committee of the Board.

(3) A member of the Executive Committee of the Board.

(4) A member of the Audit Committee of the Board.

(5) A member of the Compensation and Stock Option Committee of the Board.

     IT IS A CONDITION TO THE CONSUMMATION OF THE STOCK PURCHASE  AGREEMENT THAT
ALL NOMINEES BE ELECTED BY THE SHAREHOLDERS AT THE MEETING.  IF ALL NOMINEES ARE
NOT  ELECTED,  IF  PROPOSAL  II  AND/OR  PROPOSAL  III ARE NOT  APPROVED  BY THE
SHAREHOLDERS AT THE MEETING,  OR IF THE STOCK PURCHASE  AGREEMENT IS TERMINATED,

                                       6
<PAGE>

NONE OF THE NOMINEES WILL BE ELECTED,  THE CURRENT DIRECTORS WILL NOT RESIGN AND
THE COMPANY WILL CALL A SPECIAL  MEETING OF  SHAREHOLDERS AS SOON AS PRACTICABLE
IN ORDER TO ELECT TWO CLASS II DIRECTORS WHOSE TERMS OF OFFICE  OTHERWISE EXPIRE
THIS YEAR. If all of the nominees are not elected at the Meeting,  each of Lipha
and the Company have the right to terminate  the Stock  Purchase  Agreement.  In
such event,  it is the present  intention  of the Company to discuss  with Merck
KGaA and its  affiliates  entering  into  alternative  transactions,  subject to
applicable  laws and  regulations.  No  specific  alternative  transactions  are
currently contemplated.

     THE BOARD OF DIRECTORS UNANIMOUSLY  RECOMMENDS A VOTE "FOR" THE ELECTION OF
ALL SEVEN OF THE NOMINEES NAMED ABOVE AS DIRECTORS OF THE COMPANY.


Board and Committee Meetings
- ----------------------------

     The Board met 10 times during  fiscal year 1997 which ended  September  30,
1997. The Audit Committee met once during fiscal year 1997. The primary function
of the Audit Committee is to review the Company's financial  statements with its
auditors.  The  Compensation and Stock Option Committee held two meetings during
fiscal year 1997. The functions of the  Compensation  and Stock Option Committee
are to set and approve  salary and bonus  levels of  corporate  officers  and to
administer  the  Company's  1990  Stock   Incentive  Plan,   including   primary
responsibility  for the  granting of options and other  awards  thereunder.  The
Nominating  Committee did not meet during fiscal year 1997,  but acted in fiscal
year 1998 to review and approve the  nominees  for  election as directors at the
Meeting.   The  primary  function  of  the  Nominating   Committee  is  to  make
recommendations  to the Board  concerning the selection of nominees for election
as directors.  The Nominating  Committee will consider  candidates  suggested by
directors or shareholders.  Nominations for shareholders,  properly submitted in
writing to the  Secretary  of the  Company,  will be referred to the  Nominating
Committee for  consideration.  No other  nominees  other than those set forth in
this Proxy Statement have been properly submitted for consideration. Neither the
Executive  Committee  nor the  Strategic  Planning  Committee  had any  official
meetings during fiscal year 1997. The function of the Executive  Committee is to
exercise the powers of the Board in the  management  of the business and affairs
of the Company, subject to limits imposed by applicable law, and the function of
the  Strategic  Planning  Committee  is to  review  certain  potential  material
transactions   involving   the  Company  and  to   communicate   with  and  make
recommendations  to the  Board  in  respect  of such  transactions.  There is no
current  director who attended fewer than 75% of the meetings of the Board or of
its committees during fiscal year 1997.


Compensation of Directors
- -------------------------

     For  service  on the  Board in fiscal  year  1997,  directors  who were not
employees of the Company or any of its subsidiaries  received an annual retainer
of $12,000, a fee of $1,000 for each meeting of the Board attended, in person or
by telephone  conference,  and a fee of $750 for each committee meeting attended
in person or by  telephone  conference,  subject to a maximum of $1,750 per day.
Chairmen  of  committees  receive an  additional  annual  retainer of $5,000 per
committee.  No stock  options were granted to any directors for or during fiscal
year 1997.

     Directors  who are  employees  of the  Company  or any of its  subsidiaries
receive no remuneration  for serving as directors or as members of committees of
the Board.  All  directors  are  entitled  to  reimbursement  for  out-of-pocket
expenses  incurred in  connection  with their  attendance at Board and committee
meetings.


Certain Relationships and Related Transactions
- ----------------------------------------------

     Clal  Agreements.   On  May  1,  1995,  the  Company   consummated  several
transactions with Clal consisting  principally of (i) the sale by the Company of
2,027,272 shares of the Common Stock for $20,000,000, or $9.87 per

                                        7

<PAGE>

share, (ii) the issuance by the Company of warrants to purchase 2,005,107 shares
of Common Stock (the  "Warrants")  and (iii) the formation of a joint venture to
research and develop generic  pharmaceutical  products.  The Clal Stock Purchase
Agreement  sets forth terms of the Company's and Clal's  business  relationship,
including the issuance to Clal of the aforementioned  2,027,272 shares of Common
Stock,  rights  to  nominate  Board  members,  rights of first  refusal,  voting
agreements,  rights to invest in others,  standstill  agreements  and agreements
with respect to the issuance of the Warrants.

     In accordance with the terms of the Clal Stock Purchase Agreement, Clal has
the right to designate  one-seventh  of the members of the Board as long as Clal
owns 8% of the issued and outstanding  Common Stock, and a total of two-sevenths
of the  members  of the  Board  if Clal  owns at  least  16% of the  issued  and
outstanding Common Stock. The Company has the right to reject a designee of Clal
if such person is not  satisfactory  to the Company for good faith reasons.  The
Company also agreed to elect Clal's designee(s), if any, to the Audit Committee,
Compensation and Stock Option Committee and Strategic  Planning Committee of the
Board. Additionally,  if Clal's appointment of a director to the Audit Committee
is prohibited by the rules and regulations of The New York Stock  Exchange,  the
Company will provide Clal materials which are provided to committee members, the
appointment of the Company's  auditors will be approved by the entire Board, the
Company  will  consult  with  directors  nominated by Clal with respect to Audit
Committee  actions and are director(s)  nominated by Clal will have the right to
consent to certain changes in the Company's accounting principles.  In the event
that Clal does not  nominate  directors  to the  Board or its  committees  or if
Clal's  designees  are not  elected  to the  Board  or its  committees,  Clal is
permitted, under the Clal Stock Purchase Agreement, to designate representatives
who may attend meetings of the Board and its committees. Clal also has the right
to designate a member of the  Company's  management.  Pursuant to the Clal Stock
Purchase Agreement, Clal has designated an observer to meetings of the Board and
its committees,  but Clal has not designated any director,  nominee for director
or member of management of the Company.  Clal has the right to acquire up to 20%
of any  equity  securities  issued  by the  Company  in an  underwritten  public
offering so long as Clal,  at the time,  owns 10% of the issued and  outstanding
Common Stock.

     In consideration  of the rights and benefits  obtained by the Company under
the Clal Stock  Purchase  Agreement,  the Company  also  granted to Clal certain
registration rights under a registration rights agreement. In general, Clal will
not be able to sell freely the shares of Common Stock  purchased by Clal without
registration  under  applicable  securities  laws or  unless an  exemption  from
registration  is  available.  Clal is entitled to two demand  registrations.  In
addition,  the Company  granted to Clal the right to  register  shares of Common
Stock owned by Clal on each occasion that the Company registers shares of Common
Stock, subject to certain limitations and exceptions.

     The rights of first refusal, voting agreements and standstill agreements of
Clal have expired in accordance  with their terms and, upon  consummation of the
Stock  Purchase  Agreement,  all of Clal's  other  rights  under the Clal  Stock
Purchase  Agreement will  terminate.  Clal has agreed with the Company and Merck
KGaA to vote all of its shares of Common  Stock in favor of  Proposals I, II and
III  at  the  Meeting  pursuant  to  the  Clal  Sale  Agreement.  See  "Proposal
II-Approval of Stock Sale and Option Issuance."

     In May 1995,  the  Company  and Clal  formed a joint  venture in Israel now
called Israel  Pharmaceutical  Resources,  L.P. ("IPR"), to research and develop
generic pharmaceutical  products. On August 14,1997, the Company acquired Clal's
51%  ownership  interest in IPR for $447,000 in cash  obtained  from the sale of
Fine-Tech  Ltd.  ("Fine-Tech")  stock owned by the  Company and a  non-recourse,
secured  promissory note in the principal  amount of $1,500,000.  The note bears
interest  at 7% per  annum,  and is payable  in eight  semi-annual  installments
commencing  in July 1999.  The Company may prepay the note in full if it makes a
payment of $600,000  before  August 13, 1998.  Until the note is repaid in full,
the Company is obligated to invest $1,500,000 each year in IPR. In addition, the
Company  and Clal  agreed,  in July  1997,  to  modify  certain  terms of Clal's
investment  in the Company,  including  the surrender by Clal of the Warrants in
exchange  for the  issuance to Clal of 186,000  shares of the  Company's  Common
Stock for nominal cash consideration.


                                        8

<PAGE>

     As of April 30, 1998, Clal beneficially owned, to the Company's  knowledge,
2,313,272  shares of Common Stock.  Of such shares,  l00,000 were purchased from
Mr. Sawyer at a price of $7.125 per share in June 1996 and an additional 186,000
shares were acquired from the Company as discussed above.

     The Company  reimbursed Clal $115,000 in fiscal year 1997 for the wages and
expenses of a consultant  to the Company who was also an employee of Clal during
that period.

     Investment  in  Fine-Tech.  Under the Clal Stock  Purchase  Agreement,  the
Company  obtained  the  right  to  participate  with  Clal  and  certain  of its
affiliates  in  connection   with  certain   pharmaceutical   acquisitions   and
transactions.  In December 1995, the Company paid  $1,000,000 to purchase 10% of
the shares of  Fine-Tech,  an Israeli  pharmaceutical  research and  development
company in which Clal had a significant  ownership  interest.  In addition,  the
Company  obtained the exclusive right to purchase  certain products not commonly
sold in North  America,  South  America  and the  Caribbean.  In June 1997,  the
Company  sold all of the shares of  Fine-Tech  for  approximately  $447,000  and
terminated its exclusive purchase rights.

     Transactions with Officers, Directors and Nominees. At various times during
fiscal years 1996 and 1997, the Company made unsecured loans to Mr. Sawyer. Such
loans are evidenced by a single  promissory  note,  which bears  interest at the
rate of 8.25% per annum. Interest and principal are due on the earlier of August
14, 2002, or the termination of Mr. Sawyer's  employment with the Company. As of
April 30, 1998, the outstanding  balance of the note,  including  interest,  was
approximately  $382,000.  The  Company  has  agreed to  forgive  the note over a
three-year  period,  provided  that Mr.  Sawyer is employed by the Company.  See
"--Executive Compensation--Employment Agreements and Termination Arrangements."

     Stephen A.  Ollendorff,  nominee for election as a director of the Company,
is of counsel  to the law firm of  Hertzog,  Calamari  & Gleason,  which acts as
counsel for the Company and which  received  fees and  expenses in fiscal  years
1996 and 1997 for  various  legal  services  rendered to the  Company.  Hertzog,
Calamari & Gleason was the Company's  counsel in the preparation and negotiation
of the Stock Purchase Agreement and the preparation of this Proxy Statement. Mr.
Ollendorff  is a  consultant  to the Company and was paid $75,234 in fiscal year
1997.  Pursuant to a renewable one-year  consulting  agreement,  the Company has
agreed to pay Mr.  Ollendorff  $76,800  per year.  Mr.  Ollendorff  holds  stock
options to purchase  60,000 shares of Common Stock,  none of which are presently
exercisable.

     The Company believes that all of the above  transactions were on terms that
were fair and reasonable to the Company.


Executive Officers
- ------------------

     The executive  officers of the Company  presently  consist of Mr. Sawyer as
President,  Chief  Executive  Officer and  Chairman of the Board,  and Dennis J.
O'Connor as Vice President,  Chief Financial Officer and Secretary.  Dr. Rudi D.
Neirinckx will become President and Chief Operating  Officer of the Company upon
the consummation of the Stock Purchase Agreement.  The executive officers of Par
Pharmaceutical, Inc., the Company's principal subsidiary ("Par"), consist of Mr.
Sawyer, Mr. O'Connor and Scott Tarriff, as Executive Vice President of Business,
Sales and Marketing.

     The  following  table sets forth  certain  information  with respect to the
executive  officers of the Company and Par who are not directors or nominees for
election as directors:


                                       9

<PAGE>


Name                                                                        Age

Dennis J. O'Connor.......................................................    46
          Since October 1996,  Vice  President,  Chief  Financial
          Officer and Secretary of the Company and Par. From June
          1995 to October 1996,  Controller of Par. From November
          1989  to  June  1995,  Vice   President--Controller  of
          Tambrands, Inc., a consumer products company.

Scott Tarriff............................................................    38
          Since  January  1998,   Executive   Vice  President  of
          Business,  Sales and Marketing of Par. Since June 1989,
          an   employee   of   Bristol-Myers   Squibb,   a   drug
          manufacturer,  serving as Senior Director of Marketing,
          Business  Development and Strategic  Planning from 1995
          to 1997 and Director of Marketing from 1992 to 1995.



                      EXECUTIVE COMPENSATION

     The  following  table sets  forth  compensation  earned by or paid,  during
fiscal years 1995 through  1997, to the Chief  Executive  Officer of the Company
and the one other  executive  officer of the Company who earned over $100,000 in
salary and bonus during fiscal year 1997 (the "Named  Executives").  The Company
awarded or paid such  compensation to all such persons for services  rendered in
all capacities during the applicable fiscal years.


                    Summary Compensation Table

<TABLE>
<CAPTION>

                                          Annual Compensation   Long-Term Compensation
                                        ----------------------  ----------------------
                                                                Restricted    Securities    All Other
Name and                                                         Stock        Underlying  Compensation
Principal Position                 Year    Salary($)   Bonus($)  Awards($)(1)  Options(#)    ($)(2)
- ------------------                 ----    --------   --------- ------------- ----------- ------------
<S>                                <C>      <C>       <C>            <C>         <C>       <C>   
Kenneth I. Sawyer,.............    1997     350,000        --        --            --      12,985
President, Chief                   1996     370,692        --        --          75,000    38,530
Executive Officer                  1995     427,153   200,000        --            --      49,806
and Chairman

Dennis J. O'Connor(3)..........    1997     137,994        --        --          30,000     2,121
Vice President
Chief Financial
Officer and
Secretary
</TABLE>

- ---------- 

(1)  The Named Executives did not hold any shares of restricted stock at the end
     of fiscal year 1997.

(2)  For fiscal year 1997,  includes  insurance premiums paid by the Company for
     term life insurance for the benefit of the Named Executives as follows: Mr.
     Sawyer-$74 and Mr.  O'Connor-$51.  The amounts for Mr. Sawyer  includes the
     maximum  potential  estimated  dollar  value of the  Company's  portion  of
     insurance  premium payments from a split-dollar life insurance policy as if
     premiums were advanced to the executive without interest until the earliest
     time the  premiums  may be  refunded  by Mr.  Sawyer to the  Company.  Also
     includes the following  amount  contributed by the Company to the Company's
     401(k) plan on behalf of such Named Executive Officer: Mr. O'Connor-$2,070.


                                       10

<PAGE>

(3)  Mr.  O'Connor did not become a Named Executive until fiscal year 1997, even
     though he was employed previously by the Company.

     The  following  table  sets  forth  stock  options  granted  to  the  Named
Executives during fiscal year 1997. No stock appreciation rights were granted in
fiscal year 1997.

                     Stock Option Grants in Last Fiscal Year


<TABLE>
<CAPTION>
                                                                                          Potential Realizable
                                                                                        Value at Assumed Annual
                                                                                          Rates of Stock Price
                                                  Individual Grants                  Appreciation for Option Term(1)
                                 -------------------------------------------------   -------------------------------

                                                  % of Total
                                   Shares          Options
                                 Underlying       Granted to
                                   Options        Employees      Exercise  Expiration
Name                             Granted (#)    in Fiscal Year   Price ($)    Date     0% ($)  5% ($)   10% ($)
- ----                             -----------    --------------   --------- ----------  ------   ------   -------
<S>                                <C>             <C>           <C>        <C>        <C>    <C>       <C>     
Dennis J. O'Connor(2)..........    20,000          6.37%         $3.375     10/22/01   --     $86,149   $108,709
Dennis J. O'Connor(3)..........    10,000          3.19%         $2.125      9/7/02    --     $27,121   $ 34,223
</TABLE>

(1)  Potential  realizable  value is based upon the  assumption  that the Common
     Stock appreciates at the annual rates shown (compounded  annually) from the
     date of grant until the  expiration  of the option term.  These numbers are
     calculated  based upon the  requirements  promulgated by the Securities and
     Exchange  Commission  and do not reflect any estimate or  prediction by the
     Company of future Common Stock price increases, if any.

(2)  Represents  options granted pursuant to the Company's 1990 Incentive Option
     Plan on October 23, 1996, of which 10,000 became exercisable on October 23,
     1997 and 10,000 become exercisable on October 23, 1998.

(3)  Represents  options granted pursuant to the Company's 1990 Incentive Option
     plan on September 8, 1997,  of which 3,333 became  exercisable  on March 8,
     1998,  3,333  become  exercisable  on  March  8,  1999,  and  3,334  become
     exercisable on March 8, 2000.


     The  following  table sets forth the stock  options  exercised by the Named
Executives  during fiscal year 1997 and, as of September 30, 1997, the number of
unexercised  stock  options and the value of  in-the-money  options  held by the
Named  Executives.  No stock  appreciation  rights were exercised in fiscal year
1997.

                Aggregated Option Exercises in Last Fiscal Year
                       and Fiscal Year-End Option Values


<TABLE>
<CAPTION>
                                                        Number of Securities      Value of Unexercised
                                 Shares               Underlying Unexercised      In-the-Money Options
Name                           Acquired on   Value      Options at FY-End (#)       at FY-End ($)
- ----                                                  -----------------------    ----------------------

                               Exercise(#) Realized($) Exercisable  Unexercisable  Exercisable  Unexercisable
                               ----------- ----------- -----------  -------------  -----------  -------------

<S>                                <C>         <C>      <C>            <C>            <C>         <C>     
Kenneth I. Sawyer..........        0           0        550,000        25,000         --          --
Dennis J. O'Connor.... ....        0           0        15,833         31,667         --          --
</TABLE>

     After the close of the Company's  last fiscal year,  the Board approved the
grant of new five-year  options to the Named  Executives at an exercise price of
$2.25 per share,  upon surrender for  cancellation of certain of the options set
forth above in the table.  Pursuant to such Board action,  the Named  Executives
hold repriced options as follows: Mr. Sawyer - 500,000, and Mr. O'Connor-37,500.
All of such  repriced  options  will become  exercisable  as follows:  one third
become  exercisable  on  July  1,  1999,  and the  remaining  two-thirds  become
exercisable on July 1, 2001.



                                       11

<PAGE>


Employment Agreements and Termination Arrangements
- --------------------------------------------------

     The Company has entered into an employment agreement with Mr. Sawyer, which
provides for his  employment in his current  position  through  October 4, 2000,
subject to earlier termination by the Company for Cause (as such term is defined
in the agreement). Mr. Sawyer's agreement provides for a rolling three-year term
of employment  which is  automatically  extended each year for an additional one
year unless either party  provides  written notice by July 4th of such year that
he or it  desires  not to renew  the  agreement.  Under the  agreement  with Mr.
Sawyer,  the  Company  is  required  to use its best  efforts to cause him to be
reelected to the Board during his term of employment.  Mr.  Sawyer,  pursuant to
the terms of his employment  agreement,  is and will be required to serve, if so
elected, on the Board of Directors as well as any committees thereof.

     Mr. Sawyer's  agreement  provides for certain  payments upon termination of
his employment.  Upon termination of Mr. Sawyer's  employment  without cause (as
such term is  defined in the  agreement)  by the  Company  or for the  Company's
material  breach,  Mr.  Sawyer is entitled to receive the balance of his current
salary for the  remainder of the  employment  term and the amount of his current
bonus  multiplied  by the  number  of years  remaining  under his  agreement.  A
material breach by the Company of the employment agreement includes,  but is not
limited to, a termination without cause and a change of his responsibilities. In
the event of termination of Mr. Sawyer's employment for death, disability or for
cause,  Mr.  Sawyer is entitled to receive his current  base salary  through the
date of termination and, in the event of death or disability, a pro-rated amount
of his last annual bonus. As a result of a material breach by the Company of his
employment  agreement  following a change of control (as such term is defined in
the  agreement)  of the Company,  Mr.  Sawyer is entitled to receive,  if such a
termination  occurs  within  two years  following  the  change of control of the
Company,  a lump sum  payment  equal to the lesser of three times the sum of his
annual base salary and most recent bonus or the maximum amount permitted without
the  imposition of an excise tax on Mr. Sawyer or the loss of a deduction to the
Company under the Internal  Revenue Code of 1986, as amended (the "Code"),  plus
reimbursement of certain legal and relocation expenses incurred by Mr. Sawyer as
a result of the  termination  of his  employment  and  maintenance of insurance,
medical and other benefits for 24 months or until Mr.
Sawyer is covered by another employer for such benefits.

     In March 1998, Mr. Sawyer and the Company amended Mr.  Sawyer's  employment
agreement. Mr. Sawyer agreed to waive breaches of his employment agreement which
would arise out of consummation of the Proposed  Transaction,  relinquished  his
title and  position as President  of the Company and its  subsidiaries  if Lipha
exercises  its right to  designate  the  President  of the  Company  and/or  its
subsidiaries,  and  agreed to vote his  shares  of Common  Stock in favor of the
Proposed  Transaction.  The  Company  agreed to  forgive,  in each year that Mr.
Sawyer remains employed by the Company, one-third of the principal amount of his
promissory note, plus accrued interest on the forgiven portion.  As of April 30,
1998, the outstanding balance of the note, including interest, was $382,000. The
entire unpaid  principal of the  promissory  note and accrued  interest would be
canceled upon certain events,  including  termination of Mr. Sawyer's employment
without cause and the expiration of this employment agreement in accordance with
its terms.

     The Company has entered into a severance agreement with Mr. O'Connor, dated
October 23, 1996. The agreement provides,  with certain  limitations,  that upon
the termination of Mr. O'Connor's employment by the Company for any reason other
than for  cause or by Mr.  O'Connor  for good  reason or  following  a change of
control (as such terms are defined in the  agreement),  Mr. O'Connor is entitled
to receive a severance payment.  The amount of the payment is to be equal to six
months  of his  salary  at the  date of  termination,  with  such  amount  to be
increased  by an  additional  month of salary  for every  full month he has been
employed  by the  Company  in  his  present  position,  up to a  maximum  of six
additional month's salary.

     The Company entered into an agreement with Dr. Rudi Neirinckx,  dated March
25, 1998,  providing for his  employment by the Company  without a specific term
effective upon the closing of the Stock Purchase  Agreement.  Dr.  Neirinckx has
received  an option  to  purchase  up to  275,000  shares of Common  Stock at an
exercise  price of $_____ per share.  Such  option will expire if the closing of
the Stock  Purchase  Agreement  does not occur.  See "Proposal II -- Approval of
Stock Sale and Option Issuance." 

                                       12

<PAGE>

     The Company has entered  into an  employment  agreement  with Mr.  Tarriff,
dated February 20, 1998. Upon termination of Mr. Tarriff's employment within the
first year of  employment  other than by the  Company for cause (as such term is
defined in the  agreement),  Mr. Tarriff is entitled to receive the balance,  if
any, of his salary for the first year of employment. In the event of termination
of Mr. Tarriff's employment after one year of employment by Mr. Tarriff for good
reason (as such term is  defined in the  agreement)  or by the  Company  without
cause, Mr. Tarriff is entitled to receive a severance  payment equal to one year
of his  then  current  salary  less any  amount  of  compensation  paid by a new
employer for the balance of the year from the  termination  date.  In connection
with his employment by the Company,  he was granted options to purchase  200,000
shares of Common Stock at an exercise price of $1.50 per share.

     Under the stock option agreements with Messrs. Sawyer, O'Connor,  Neirinckx
and  Tarriff,  any  unexercised  portion  of  the  options  becomes  immediately
exercisable  in the event of a change of  control  (as such term is  defined  in
their  agreements).  However,  each of such persons has agreed that the Proposed
Transaction  does not  constitute  a change in  control  under his stock  option
agreement.  Each of Messrs.  Sawyer,  Neirinckx  and Tarriff  have agreed not to
exercise  his stock  options for a period of three  years and 10  business  days
following  the closing of the Stock  Purchase  Agreement,  and Mr.  O'Connor has
agreed not to exercise his stock  options  during the three years  following the
closing of the Stock Purchase Agreement, except for installments of one-third of
his stock options on each of the anniversaries of the closing.


Pension Plan
- ------------

     The Company  maintains a defined benefit plan (the "Pension Plan") intended
to qualify under  Section 401 (a) of the Code.  Effective  October 1, 1989,  the
Company ceased  benefit  accruals under the Pension Plan with respect to service
after such  date.  The  Company  intends  that  distributions  will be made,  in
accordance  with the terms of the Plan, to  participants  as of such date and/or
their  beneficiaries.  The Company will  continue to make  contributions  to the
Pension Plan to fund its past service obligations.  Generally,  all employees of
the Company or a participating subsidiary who had completed at least one year of
continuous  service and attained 21 years of age were eligible to participate in
the Pension Plan. For benefit and vesting  purposes,  the Pension Plan's "Normal
Retirement Date" is the date on which a participant attains age 65 or, if later,
the date of completion of 10 years of service. Service is measured from the date
of employment.  The retirement income formula is 45% of the highest  consecutive
five-year average basic earnings during the last 10 years of employment, less 83
1/3% of the participant's Social Security benefit,  reduced  proportionately for
years of service less than 10 at retirement.  The normal form of benefit is life
annuity, or for married persons, a joint survivor annuity.  Neither of the Named
Executives has any years of credited service under the pension plan.

     Par currently  maintains a retirement  plan (the  "Retirement  Plan") and a
retirement savings plan. The Board of Directors of Par directed the cessation of
employer  contributions  to the  Retirement  Plan  effective  December 30, 1996.
Consequently,  participants in the Retirement Plan will no longer be entitled to
any employer contributions under such Plan for 1996 or subsequent years.


Compensation and Stock Option Committee Report
- ----------------------------------------------

     The Compensation and Stock Option Committee of the Board (the "Compensation
Committee"),  consisting entirely of non-employee directors, approves all of the
policies and programs  pursuant to which  compensation is paid or awarded to the
Company's executive officers and key employees.  The Compensation Committee held
two meetings

                                       13

<PAGE>


in fiscal year 1997. In reviewing overall compensation for fiscal year 1997, the
Compensation  Committee focused on the Company's objectives to attract executive
officers  of  high   caliber  from   larger,   well-established   pharmaceutical
manufacturers,  to retain the  Company's  executive  officers,  to encourage the
highest  level of  performance  from such  executive  officers  and to align the
financial interests of the Company's management with that of its shareholders by
offering  awards that can result in the ownership of Common  Stock.  The Company
did not utilize  specific  formulae or  guidelines  in reviewing  and  approving
executive compensation.

     Elements of Executive Officer Compensation Program. The key elements of the
Company's executive officer compensation program consist of base salary,  annual
bonus,  stock options and other incentive  awards through  participation  in the
Company's 1990 Stock  Incentive  Plan. In awarding or approving  compensation to
executive  officers in fiscal year 1997, the Compensation  Committee  considered
the present and potential  contribution of the executive  officer to the Company
and the  ability  of the  Company  to attract  and  retain  qualified  executive
officers in light of the competitive  environment of the Company's  industry and
the Company's financial condition.

     Base Salary and Annual  Bonus.  Base salary and annual bonus for  executive
officers are determined by reference to Company-wide and individual performances
for the  previous  fiscal  year.  The  factors  considered  by the  Compensation
Committee  included both strategic and operational  factors,  such as efforts in
responding  to  regulatory   matters,   efforts  in   exploration  of  strategic
alternatives for the Company, such as the strategic alliance with Clal, research
and development  expenditures,  review and implementation of updated systems and
operational  procedures as a foundation for future growth and realignment of the
Company's  internal sales and marketing  organization,  as well as the Company's
financial performance. In addition to Company-wide measures of performance,  the
Compensation  Committee  considers those performance  factors particular to each
executive officer,  including the performance of the area for which such officer
had management responsibility and individual accomplishments.

     Base salaries for executive officers were determined primarily by reference
to industry norms, the principal job duties and  responsibilities  undertaken by
such persons,  individual  performance and other relevant criteria.  Base salary
comparisons for most executive  officers were made to a group of  pharmaceutical
manufacturers in the United States.  Such group was selected by the Compensation
Committee based upon several factors,  including, but not limited to, the duties
and  responsibilities of the executive officer used in the comparison,  size and
complexity of operations, reputation and number of employees of other companies.
With respect to Mr. Sawyer,  the Company's Chief Executive Officer, a comparison
was  made  by an  independent  consulting  firm,  prior  to the  signing  of his
employment agreement in 1992, to generic pharmaceutical companies and turnaround
situations  selected  by the  consulting  firm.  In  keeping  with  its  goal of
recruiting  executive  officers  from  larger,  well-established  pharmaceutical
manufacturers,  the  Compensation  Committee  considered the  performance of the
companies used in the  comparisons,  as measured by their quality and regulatory
profile,  as well as  competitive  necessity in determining  base salaries.  The
Compensation Committee considered it appropriate and in the best interest of the
Company and its  shareholders to set the levels of base salary for the Company's
Chief Executive Officer and other executive officers at the median of comparable
companies in order to attract and retain high  caliber  managers for the Company
so as to position the Company for future growth and improved performance.

     The Compensation Committee, in determining the annual bonuses to be paid to
its  executive  officers  for fiscal  year  1997,  considered  the  individual's
contribution  to the Company's  performance  as well as the Company's  financial
performance  and  assessments  of each  executive  officer's  participation  and
contribution to the other factors  described  above, as opposed to determination
by reference to a formal,  goal-based  plan. The  non-financial  measures varied
among executive  officers  depending upon the operations  under their management
and  direction.  The  Compensation  Committee  did not grant any cash bonuses in
fiscal year 1997 to the Named Executives.

     Stock Options and Other Awards.  The Company's  1990 Stock  Incentive  Plan
provides for stock option and other  equity-based  awards.  Under such Plan, the
size of each award and the persons to whom such awards are granted is determined
by the Compensation  Committee based upon the nature of services rendered by the
executive officer, the

                                       14

<PAGE>



present and potential contribution of the grantee to the Company and the overall
performance of the Company.  The Compensation  Committee believes that grants of
stock  options will enable the Company to attract and retain the best  available
talent and to encourage the highest level of performance in order to continue to
serve the best interests of the Company and its shareholders.  Stock options and
other  equity-based  awards provide  executive  officers with the opportunity to
acquire  equity  interests in the Company and to  participate in the creation of
shareholder value and benefit correspondingly with increases in the price of the
Common Stock.

     Compensation  Committee's  Actions for Fiscal Year 1997. In determining the
amount and form of  executive  officer  compensation  to be paid or awarded  for
fiscal year 1997, the Compensation  Committee  considered the criteria discussed
above.  In light of the  reduction in sales in fiscal year 1997 from fiscal year
1996 and the Company's financial condition,  the Compensation  Committee did not
award cash bonuses to the Named Executives.  The Compensation  Committee awarded
stock  options  to  Mr.  O'Connor  in  consideration  of  his  reaching  certain
objectives  and to increase the incentive for him to contribute to the financial
success of the Company.

     Chief Executive Officer Compensation.  The Compensation  Committee approved
an  employment  agreement in October  1992 for Mr.  Sawyer.  In  approving  such
employment agreement, the Compensation Committee authorized a base annual salary
of $366,993 for Mr.  Sawyer.  Mr. Sawyer  agreed to reduce his salary  effective
July 1, 1996 to  $350,000  per year.  No cash  bonuses,  stock  options or other
awards were granted to Mr.  Sawyer in fiscal year 1997 in view of the  Company's
operating results and financial condition.


                     Compensation and Stock Option Committee

                                  Mark Auerbach
                                  H. Spencer Matthews
                                  Robin O. Motz


Compensation Committee Interlocks and Insider Participation
- -----------------------------------------------------------

     The Compensation Committee, consisting of Messrs. Auerbach and Matthews and
Dr.  Motz for fiscal year 1997,  conducted  deliberations  concerning  executive
officer  compensation  during  the  last  completed  fiscal  year.  None  of the
Compensation  Committee  members are or ever were  officers or  employees of the
Company.  During the last fiscal  year,  none of the  executive  officers of the
Company has served on the board of directors or on the compensation committee of
any other entity,  any of whose  executive  officers  served on the Board of the
Company.


Section 16(a) Beneficial Ownership Reporting Compliance
- -------------------------------------------------------

     As a public company, the Company's  directors,  executive officers and more
than 10% beneficial owners are subject to reporting  requirements  under Section
16(a) of the Securities Exchange Act of 1934, as amended.  None of the Company's
directors,  executive officers or such 10% beneficial owners delinquently filed,
to the Company's knowledge, any reports required under Section 16(a) of such Act
during fiscal year 1997.


Performance Graph
- -----------------

     The graph below  compares the  cumulative  total return of the Common Stock
with the cumulative total return of The New York Stock Exchange  Composite Index
and the S&P(R)  Health Care Drugs Index - Major  Pharmaceuticals  for the annual
periods from  September 30, 1992 to September  30, 1997.  The graph assumes $100
was invested on

                                       15

<PAGE>



September  30,  1992 in the Common  Stock and $100 was  invested on such date in
each of the Indexes. The comparison assumes that all dividends were reinvested.




                               [Performance Graph]



<TABLE>
<CAPTION>
                                               Sept.-92  Sept.-93  Sept.-94  Sept.-95  Sept-.96  Sept.-97
                                               --------  --------  --------  --------  --------  -------
<S>                                               <C>      <C>       <C>       <C>      <C>       <C> 
Pharmaceutical Resources, Inc. .................  $100     $191      $132      $143     $ 64      $ 32
NYSE Composite Index ...........................  $100     $115      $119      $145     $174      $240
S&P(R)Health Care Drugs ........................  $100     $ 81      $ 97      $153     $207      $314
Index-Major Pharmaceuticals

</TABLE>

                                   PROPOSAL II

                   APPROVAL OF STOCK SALE AND OPTION ISSUANCE

General
- -------

     At the  Meeting,  the holders of Common  Stock will be asked to approve the
sale of 10,400,000  shares (the "Shares") of Common Stock to Lipha, a subsidiary
of Merck KGaA, at $2.00 per share,  and the grant and issuance to Merck KGaA and
Genpharm,  a  subsidiary  of Merck  KGaA,  of options  (each,  an  "Option"  and
collectively,  the "Options") to purchase up to an aggregate of 1,171,040 shares
(the "Option Shares") of Common Stock at an exercise price of $2.00 per share in
exchange for certain  services.  The sale of the Shares will be made pursuant to
the terms and conditions of that certain Stock Purchase  Agreement,  dated March
25, 1998,  between the Company and Lipha (the "Stock Purchase  Agreement").  The
grant and issuance of the Options will be made pursuant to terms and  conditions
of separate  Services  Agreements to be entered into with each of Merck KGaA and
Genpharm upon the closing of the Stock  Purchase  Agreement.  The Shares and the
Option  Shares  together  will  constitute  approximately  38% of the issued and
outstanding  Common Stock after giving effect to, and as of the anticipated date
of  closing  of,  the  transactions  (the  "Closing")  under the Stock  Purchase
Agreement (the "Closing Date").

     Approval  of  Proposal  II is required in order to comply with the rules of
The New York Stock  Exchange  and to satisfy a  condition  to the Closing of the
Stock Purchase  Agreement.  The rules of The New York Stock Exchange require the
Company to obtain  prior  shareholder  approval of the  issuance  of  securities
(including, for this purpose, options to purchase Common Stock) representing 20%
or more of the Common Stock issued and  outstanding  before the issuance of such
securities.  Based upon the  number of  presently  outstanding  shares of Common
Stock,  the Shares and the Options on the Closing Date will constitute more than
20% of the outstanding Common Stock. The approval of the Proposed Transaction by
the Company's  shareholders  is a  non-waivable  condition to the Closing of the
Stock  Purchase  Agreement.  Accordingly,  if the  Proposed  Transaction  is not
approved  by the  Company's  shareholders,  the Stock  Purchase  Agreement,  the
related  agreements  and  the  transactions  contemplated  thereby  will  not be
consummated.  In such event, management of the Company will continue its efforts
to seek equity and/or debt financing and/or other strategic alliances,  although
there  can be no  assurance  whether  any such  financing  or  alliance  will be
available  on terms as  favorable as the Stock  Purchase  Agreement  and related
agreements or otherwise on terms acceptable to the Company or at all.

                                       16

<PAGE>



     The Board  believes that the Proposed  Transaction is in the best interests
of the Company and its  shareholders.  The Company  intends to use a significant
portion of the net cash  proceeds to be received  upon the sale of the Shares to
repay  certain  advances  made to it under its  existing  line of credit and the
remainder is expected to be used for working capital, including expansion of the
Company's  operations.  The  agreement  by the Company to sell the Shares and to
grant and issue the  Options  is also part of an  overall  transaction  in which
certain  exclusive  distribution  rights and  services are to be provided to the
Company  under  the  Distribution  Agreement  and the  Services  Agreements,  as
described in "-Background" below.

     THE BOARD  HAS  UNANIMOUSLY  APPROVED  THE STOCK  PURCHASE  AGREEMENT,  THE
DISTRIBUTION   AGREEMENT,   THE  SERVICES   AGREEMENTS,   THE  OPTIONS  AND  THE
TRANSACTIONS  CONTEMPLATED  THEREBY,  INCLUDING  THE SALE OF THE  SHARES AND THE
GRANT AND ISSUANCE OF THE OPTIONS.  SEE "-REASONS FOR THE PROPOSED  TRANSACTION"
BELOW.

Background
- ----------

     Over the past several  years,  the Company has been searching for strategic
transactions,  including equity investments,  acquisitions, joint ventures and a
sale of part or all of the  Company.  This search  intensified  over the last 18
months  because  of  the  Company's  declining  sales  and  profit  margins  and
significant  operating losses. The Company had discussions and negotiations with
numerous  parties in the United  States and  elsewhere,  including  Merck  KGaA.
However,  no definitive  agreements  were ever entered into. In  determining  to
approve the Proposed  Transaction,  the Board  principally  noted that the Stock
Purchase Agreement and the other agreements  contemplated  thereby will have the
effect of providing the Company with  approximately $21 million to repay certain
advances under its line of credit and additional  working  capital while, at the
same time,  strengthening  its product line by adding  approximately 40 products
being developed by Genpharm and its affiliates and to be distributed exclusively
in the United  States by the  Company  pursuant  to the  Distribution  Agreement
without  requiring the significant  investment by the Company in the development
of such products. A few of the products to be distributed under the Distribution
Agreement have received U.S. Food and Drug  Administration  ("FDA")  approval of
Abbreviated New Drug Applications  ("ANDAs") and Genpharm has filed (but has not
received FDA  approval)  and  anticipates  filing ANDAs for other  products.  In
addition,   Merck  KGaA  and  its  affiliates  will  provide  various  services,
expertise,  technical  assistance  and  support to the  Company  pursuant to the
separate Services Agreements.

     Stock  Purchase  Agreement.  On the Closing Date,  the Company will sell to
Lipha the Shares at an aggregate purchase price of $20,800,000 in cash, or $2.00
per Share.  The closing  price of a share of Common  Stock on The New York Stock
Exchange on March 25, 1998, the day the Stock  Purchase  Agreement was executed,
was $2.625 per share,  and, on May __, 1998,  was $_____ per share.  The Shares,
upon issuance at the Closing, will not be registered under the Securities Act of
1933, as amended (the "Securities Act").  However,  Lipha has certain demand and
piggy-back  registration  rights with respect to the Shares.  See "-Registration
Rights  Agreement"  below.  The  Stock  Purchase   Agreement   contains  certain
significant  terms,  obligations  and  other  agreements,  as  described  below,
including the  obligation to grant and issue the Options in return for the right
to receive certain services,  Lipha's right to designate a majority of the Board
members,  Lipha's right of first refusal in respect of certain equity offerings,
Lipha's  agreement not to engage in certain  extraordinary  transactions and the
agreement to seek shareholder  approval for the sale of the Shares and the grant
and issuance of the Options.

     Board  Representation.  Lipha has the right to  designate a majority of the
members of the Board,  subject to and  effective  upon the Closing.  Pursuant to
this right,  Lipha has  designated  Messrs.  Neirinckx,  [ ], [ ] and [ ]. Three
members  of the  Board  will be  comprised  of Mr.  Sawyer  and  two  additional
designees of the current  Board  (collectively,  the "Company  Designees").  The
Board has designated Messrs. Auerbach and Ollendorff.  All of such seven persons
have been nominated by the Nominating  Committee of the Board to be nominees for
election as directors to be voted upon at the Meeting.  See "Proposal I-Election
of Directors."  In addition,  Lipha will have the right to designate (i) jointly
with the  Company  Designees,  two  members of the Board to  comprise  the Audit
Committee of the Board and (ii) the President and Chief Operating Officer of the
Company and each of its subsidiaries. Mr.

                                       17

<PAGE>



Sawyer will  continue to serve as Chairman  and Chief  Executive  Officer of the
Company and each of its subsidiaries.  The effect of the foregoing agreements is
to afford  voting  control to the  designees  of Lipha  with  respect to matters
determined  by the Board.  Lipha has  designated  Dr. Rudi  Neirinckx  to become
President  and Chief  Operating  Officer of the Company.  The current  Board has
elected  Dr.  Neirinckx  to such  positions  subject to and  effective  upon the
Closing.  Until the  earlier  of the  Closing  or the  termination  of the Stock
Purchase  Agreement,  Dr. Neirinckx is serving the Company as a paid consultant.
Pursuant to an agreement with no specific  employment  term, Dr. Neirinckx will,
subject to the Closing, receive an annual salary of $275,000 year, and a minimum
bonus of $25,000 in 1998. Dr.  Neirinckx has received  options to purchase up to
275,000  shares of Common Stock at an exercise  price of $_____ per share.  Such
options automatically expire if the Stock Purchase Agreement does not close. See
"Executive Compensation-Employment Agreements and Termination Arrangements."

     Right of First  Refusal.  Lipha  will have a right of first  refusal  for a
period of six years  following  the Closing  Date to purchase  all, but not less
than all, of any equity  securities  to be sold by the  Company  pursuant to any
proposed  non-registered offering or any registered offering solely for cash. If
Lipha does not exercise its first  refusal  rights within 30 days of notice from
the  Company,  the  Company  may sell  such  securities  to any  third  party on
substantially  the same terms and  conditions  as first  offered  to Lipha.  The
Shares and the Option Shares do not have any preemptive rights.

     Limitations  on  Related  Party  Transactions  and  Business  Combinations;
Lock-up.  Lipha has agreed,  for a period of three years  following  the Closing
Date, not to cause or permit the Company to engage in any  transactions or enter
into any  agreements or  arrangements  with, or make any  distributions  to, any
Affiliate  or Associate  (each as defined in the Stock  Purchase  Agreement)  of
Lipha without the prior written consent of a majority of the Company  Designees.
In addition, Lipha has agreed, for a period of three years following the Closing
Date, not to propose that the Company, or cause or permit the Company to, engage
in business combinations or other extraordinary transactions,  including mergers
and tender  offers,  without  the prior  written  consent  of a majority  of the
Company  Designees  and  the  prior  receipt  of  a  fairness  opinion  from  an
independent nationally recognized investment bank.

     As a  condition  to the  Closing,  certain  holders of options to  purchase
Common Stock,  including Mr. Sawyer, Dr. Neirinckx and Mr. Tarriff,  have agreed
not to exercise  their  options for a period of three years and 10 days from the
Closing and certain  other  holders,  including  the  current  directors  of the
Company,  have  agreed not to  exercise  more than  one-third  of their  options
annually commencing on the first anniversary of the Closing Date.

     The Closing is subject to certain  conditions,  including,  but not limited
to,  obtaining all necessary  consents,  expiration or termination of applicable
waiting periods under the Hart-Scott-Rodino  Antitrust Improvements Act of 1976,
Merck KGaA's  purchase of the shares of Common  Stock from Clal  pursuant to the
Clal Sale Agreement, absence of litigation, confirmation of the fairness opinion
by Gruntal & Co.,  L.L.C.,  financial  advisor to the Company  ("Gruntal"),  and
approval by the Company's  shareholders of Proposals I, II and III in this Proxy
Statement.

     The foregoing description of the terms and conditions of the Stock Purchase
Agreement  does not purport to be complete  and is  qualified in its entirety by
reference to the Stock Purchase Agreement, a copy of which is attached hereto as
Exhibit A and incorporated herein by reference.

     Distribution  Agreement.  In connection with the Stock Purchase  Agreement,
Genpharm and the Company have entered into a Distribution Agreement, dated March
25, 1998 (the  "Distribution  Agreement"),  pursuant to which  Genpharm  granted
exclusive  distribution  rights to the  Company  within  the  United  States and
certain  other  U.S.  territories  with  respect  to  approximately  40  generic
pharmaceutical  products  currently under  development or being sold by Genpharm
and its  affiliates  outside of the United  States.  Products may be added to or
removed  from the  Distribution  Agreement  by mutual  agreement of the parties.
Genpharm  is  required  to use  commercially  reasonable  efforts to develop the
products which are subject to the Distribution  Agreement and is responsible for
the  completion  of  product   development  and  for  obtaining  all  applicable
regulatory  approvals.  The  Company  will pay  Genpharm a  percentage  of gross
profits  attributable to sales of such products.  The Company  believes that the
Distribution Agreement is

                                       18

<PAGE>



beneficial to the Company and its shareholders in that it immediately provides a
potential pipeline of a significant number of additional  products to be sold by
the Company  without the tremendous  financial  investment and the  accompanying
risk involved with new product development. If the Closing does not occur before
July 16, 1998, the Distribution  Agreement will be immediately terminable at the
option of  Genpharm  with  respect to certain  products  and  otherwise  will be
terminable at the option of Genpharm on March 25, 1999.

     Services Agreements.  At, and as a condition to, the Closing, each of Merck
KGaA and  Genpharm  will enter into a Services  Agreement,  effective  as of the
Closing  Date,  to provide  various  services  to the Company for a period of 36
months,  including, but not limited to, rendering advice and providing technical
support and  assistance  in the areas of research  and  development,  regulatory
compliance,    manufacturing,    quality   control   and   quality    assurance,
administration,  marketing  and promotion  (collectively,  the  "Services").  In
consideration of providing the Services, the Company will issue, at the Closing,
an Option to Merck KGaA to purchase up to 820,000  shares of Common Stock and an
Option to Genpharm to purchase up to 351,040 shares of Common Stock.

     Options. The Options will entitle Merck KGaA and Genpharm to purchase up to
an aggregate of 1,171,040  Option Shares at an exercise price of $2.00 per share
with  one-third of the total Option  shares  vesting each year after the date of
grant.  The Options will be exercisable at any time beginning three years and 10
days following the Closing Date and will terminate,  to the extent  unexercised,
on April 30,  2003.  The  Options  contain  provisions  that  protect the holder
against  dilution by adjustment  of the exercise  price and the number of Option
Shares issuable upon exercise in certain events, such as stock dividends,  stock
splits,  consolidation,  merger,  or  sale  of all or  substantially  all of the
Company's  assets.  The  holder  of the  Options  does not have any  rights as a
shareholder of the Company unless and until the Options have been exercised. The
Options and the Option Shares will not be registered  under the Securities  Act.
However,  the Option Shares may be registered  upon the exercise of registration
rights by the holders of the Options  and/or Option  Shares  pursuant to certain
demand  and  piggy-back   registration  rights  under  the  Registration  Rights
Agreement described below.

     Clal Sale Agreement.  Pursuant to a letter agreement, dated March 25, 1998,
between the Company,  Merck KGaA and Clal (the "Clal Sale Agreement"),  Clal has
agreed to sell to Merck KGaA (or its designee) on the Closing Date, an aggregate
of  1,813,272  shares  of  Common  Stock  at a price  of $2.00  per  share.  The
consummation of the sale of such shares is conditioned  upon the consummation of
the Stock Purchase Agreement.  Merck KGaA also agreed to pay Clal, on the second
anniversary  of the Closing Date, an amount equal to the excess,  if any, of the
weighted  average  trading  price of all trades in shares of Common Stock on The
New York Stock  Exchange  during the 30 trading  days  preceding  such date over
$2.00,  multiplied  by 500,000.  In addition,  Clal has the right to cause Merck
KGaA and/or the Company to purchase  Clal's  remaining  500,000 shares of Common
Stock three years and 10 days after the Closing Date, in certain  circumstances,
at a price of $2.50 per share (the shares of Common Stock to be  purchased  from
Clal under the Clal Sale Agreement are referred to herein as the "Clal Shares").
If Clal does not exercise  such right,  then Merck KGaA and the Company have the
right  to  cause  Clal to  sell  all of its  remaining  shares  in  open  market
transactions  and Merck KGaA and the Company will  purchase from Clal all shares
which have not been sold within 90 days.  Clal has agreed,  for a three-year and
five-day  period  following  the  Closing,  not to acquire or sell,  directly or
indirectly,  any shares of Common  Stock,  other than  pursuant to the Clal Sale
Agreement,  enter into any  agreement  with  respect to the  voting,  holding or
transferring  of any shares of Common Stock or to propose or  participate in any
transactions  involving  the  Company  or  recommend  others to take any of such
actions. Clal also agreed,  pursuant to the Clal Sale Agreement,  to vote all of
its shares of Common Stock in favor of the election of all nominees for director
and for  Proposals  II and  III.  Upon the  Closing,  the  Clal  Stock  Purchase
Agreement will terminate.

     Registration Rights Agreement.  In consideration of the rights and benefits
obtained by the Company under the Stock Purchase Agreement and the services that
will be provided to the Company  pursuant to the  Services  Agreements  and as a
condition  to the  Closing,  the  Company  will  grant to Lipha,  Merck KGaA and
Genpharm  (collectively,  the  "Holders")  certain  registration  rights under a
registration  rights  agreement,  which will become  effective as of the Closing
Date (the "Registration Rights Agreement").  In general, the Holders will not be
able to freely sell the Shares,

                                       19

<PAGE>



the Option Shares or the Clal Shares  (collectively,  the "Registrable  Shares")
without  registration  under  applicable  securities laws or unless an exemption
from registration is available.

     Starting  nine months  after the  Closing,  the Holders will be entitled to
three demand  registrations  of  Registrable  Shares and two  additional  demand
registrations if the Options are exercised.  In addition, the Company will grant
to the Holders the right to register  the  Registrable  Shares on each  occasion
that  the  Company  registers  shares  of  Common  Stock,   subject  to  certain
limitations  and  exceptions.  If the  Company at any time  registers  shares of
Common  Stock  for  sale to the  public,  the  Holders  will  agree  not to sell
publicly,  make any short sale or grant any option for the purchase or otherwise
publicly  dispose of shares of Common Stock during the same period  during which
directors and executive officers of the Company are similarly limited in selling
the  Company's  securities  up to 180  days  after  the  effective  date  of the
applicable registration statement.

     Upon the Closing, Merck KGaA will beneficially own approximately 42% of the
outstanding  Common Stock  (including the shares to be purchased  under the Clal
Sale  Agreement).  If Merck KGaA and its affiliates  exercise the Options (after
they become fully  exercisable  three years and 10 days after the Closing  Date)
and acquire all remaining  Clal Shares three years and 10 days after the Closing
Date,  Merck KGaA would  beneficially own  approximately  46% of the outstanding
Common Stock. As a result of its large stock ownership,  Merck KGaA would likely
be able to exercise control over matters requiring shareholder  approval.  This,
together  with  Lipha's  ability  to  designate  a  majority  of  the  Company's
directors,  would likely have the effect of delaying,  making more  difficult or
preventing any change in control of the Company not desired by Merck KGaA.

Reasons for the Proposed Transaction
- ------------------------------------

     The United  States  generic  pharmaceutical  industry  in which the Company
operates  has  continued  to be extremely  competitive,  with pricing  pressures
coming from both competitors  and, more recently,  the channels of distribution.
As a result of this and the lack of significant profitable new products to sell,
the Company has  incurred  significant  operating  losses in its last two fiscal
years. In recognition of the foregoing,  the Company has disclosed in its annual
and quarterly  reports its need to sell new  products,  whether  distributed  or
manufactured,  in order to offset continuing losses. As a result of its weakened
financial  condition,  the Company has not had the  resources to dedicate to the
significant research and development  activities necessary to develop additional
new products.  The Company has also disclosed its search for strategic alliances
to strengthen its financial  condition and product line. The Board believes that
the  Proposed  Transaction  addresses  both of these  needs  through  the  Stock
Purchase Agreement and the Distribution Agreement.

     The management of the Company,  with Board discussion and review,  actively
pursued and carefully  reviewed a number of potential  financing and acquisition
proposals  over the past several  years.  However,  no definitive  agreements or
binding  letters of intent  were  entered  into by the  Company  with any of the
entities with which the Company had discussions. Although the Company has raised
funds  through a  secured,  asset-based  line of  credit,  such  funding  is not
permanent financing for the Company and alternate funding and additional funding
is needed for the  long-term  requirements  of the  Company.  In  addition,  the
Company  believed  that  it did  not  have  available  the  necessary  financial
resources to support the Company's operations during any extended period of time
required to search for and  complete a different  strategic  transaction.  Based
upon internal discussions and discussions with financial advisors, the Board did
not  believe  that a public  offering  or  private  placement  of the  Company's
securities  would likely raise  capital for the Company  sufficient  to meet its
long-term  financing  requirements  on terms  which  are  equivalent  to or more
advantageous  than those available  through the Proposed  Transaction.  Further,
there were no other  viable  strategic  alliances  available  to the  Company on
equivalent or better terms.

     The  management  of the Company and the Board have  carefully  reviewed the
terms  of the  Proposed  Transaction  as  well  as the  financial  strength  and
substantial  pharmaceutical  operations of Merck KGaA and its affiliates.  Merck
KGaA is a  multi-national  specialty  pharmaceuticals,  laboratory and chemicals
company with in excess of $4 billion

                                       20

<PAGE>



in  annual   sales,   of  which  $2.5   billion  in  sales  were   derived  from
pharmaceuticals.  Also,  the Company has had successful  business  dealings with
Genpharm and an affiliate since 1992 in the form of distribution agreements with
the Company.

     The  terms  of the  Stock  Purchase  Agreement,  including  the sale of the
Shares,  the grant of the Options for services and the related  agreements  were
negotiated  at  arms'  length  between  the  Company  and  Merck  KGaA  and  its
affiliates. At its March 25, 1998 meeting, the Board unanimously determined that
the price to be paid for the Shares  and the  transactions  contemplated  by the
Stock Purchase Agreement,  the Distribution  Agreement,  the Services Agreements
and the Options,  are, taken as a whole,  from a financial point of view, in the
best interests of the Company and its  shareholders.  The  determination  of the
Board was based upon  consideration  of a number of factors.  The following list
set forth the  material  factors  the Board  considered  in its  evaluation  and
approval of the Proposed Transaction:

     (i) the  immediate  cash  investment  provides  necessary  capital  for the
Company  to reduce  its  borrowings,  to fund its  operations  and to expand its
business;

     (ii) the  Distribution  Agreement  broadens the Company's  existing generic
product line with both  near-term and long-term  products  which are expected to
increase the Company's cash flow;

     (iii) the  Distribution  Agreement  provides  the Company with an immediate
short-term and long-term product pipeline which would otherwise take the Company
a significant number of years and financial resources to develop;

     (iv) because the Proposed  Transaction involves the issuance of new capital
stock to Lipha and not a buy-out of the  Company's  outstanding  capital  stock,
existing shareholders of the Company will have the opportunity to participate in
any future growth and  profitability of the Company  resulting from the Proposed
Transaction,  including  through any  increase in the market value of the Common
Stock;

     (v) Merck KGaA's financial,  product and operational  strength could enable
the  Company  to  respond  more  effectively  to  the  competitive  and  rapidly
consolidating generic drug industry;

     (vi)  the   opportunities  to  achieve   distribution,   manufacturing  and
development efficiencies and synergies;

     (vii)  the  Services   Agreements   provide  the  Company  with  additional
significant  expertise  and  support in  research  and  development,  financing,
marketing and manufacturing;

     (viii)the  potential  increases in product  innovation  resulting  from the
combination  of the generic drug  research and  development  activities of Merck
KGaA and the Company;

     (ix) the absence of any known viable alternative strategic  transactions or
financings;

     (x) an  alliance  with a company of Merck  KGaA's  stature  may enhance the
Company's future business opportunities;

     (xi) the  structure of the Proposed  Transaction  preserves  the  Company's
ability to utilize its substantial federal net operating loss carryforward; and

     (xii) the written  opinion,  dated March 25, 1998, of Gruntal to the effect
that the price to be paid for the Shares and the  transactions  contemplated  by
the  Stock  Purchase  Agreement,   the  Distribution  Agreement,   the  Services
Agreements  and the Options  are,  taken as a whole,  from a financial  point of
view, fair to the Company's shareholders.


                                       21

<PAGE>



     The foregoing  discussion of the information and factors  considered by the
Board is not intended to be  exhaustive  but is believed to include the material
factors  considered by the Board. In view of the wide variety of information and
factors  considered,  the  Board  did not  find it  practical  to,  and did not,
quantify or otherwise  assign any relative or specific  weights to the foregoing
factors,  and individual directors may have given differing weights to different
factors.

     THE BOARD HAS  UNANIMOUSLY  APPROVED THE STOCK SALE AND OPTION ISSUANCE AND
UNANIMOUSLY  RECOMMENDS THAT THE SHAREHOLDERS VOTE TO APPROVE THE STOCK SALE AND
OPTION ISSUANCE.

Opinion of the Company's Financial Advisor
- ------------------------------------------

     The Company engaged Gruntal to render an opinion as to the fairness, from a
financial point of view, of the  consideration to be paid for the Shares and the
transactions  contemplated by the Proposed Transaction.  On March 25, 1998, at a
meeting of the Board held to evaluate the Proposed Transaction, Gruntal rendered
to the Board an oral  opinion  (which  opinion  was  subsequently  confirmed  by
delivery of a written opinion,  dated March 25, 1998, and updated to the date of
this Proxy  Statement),  to the effect that,  as of the date of such opinion and
based upon and subject to certain matters stated  therein,  the price to be paid
for  the  Shares  and  the  transactions  contemplated  by  the  Stock  Purchase
Agreement,  the Distribution Agreement,  the Services Agreements and the Options
are fair,  taken as a whole,  to the Company from a financial  point of view. In
connection with its confirmatory  letter dated the date of this Proxy Statement,
Gruntal  updated  certain  of the  analyses  performed  in  connection  with its
opinion,  dated March 25,  1998,  and  reviewed  the  assumptions  on which such
analyses were based and the factors considered in connection therewith.

      THE FULL TEXT OF THE  WRITTEN  OPINION  OF  GRUNTAL,  WHICH SETS FORTH THE
ASSUMPTIONS MADE,  MATTERS  CONSIDERED AND LIMITATIONS OF THE REVIEW UNDERTAKEN,
IS  ATTACHED  HERETO AS  EXHIBIT  B AND IS  INCORPORATED  HEREIN  BY  REFERENCE.
GRUNTAL'S  OPINION IS DIRECTED TO THE BOARD,  ADDRESSES ONLY THE FAIRNESS OF THE
PURCHASE  PRICE FOR THE SHARES AND THE  RELATED  TRANSACTIONS  FROM A  FINANCIAL
POINT OF VIEW TO THE COMPANY AND DOES NOT  CONSTITUTE  A  RECOMMENDATION  TO ANY
SHAREHOLDER AS TO HOW SUCH SHAREHOLDER  SHOULD VOTE AT THE MEETING.  THE SUMMARY
OF THE OPINION OF GRUNTAL IN THIS PROXY  STATEMENT  IS QUALIFIED IN ITS ENTIRETY
BY REFERENCE TO THE FULL TEXT OF SUCH OPINION.

     Overview  of  Analyses.  Gruntal  used both  quantitative  and  qualitative
assessments  to  evaluate  the  Company.   Gruntal's   determination   that  the
consideration to be received by the Company in the proposed transaction is fair,
from a financial  point of view,  to the Company  based on all  qualitative  and
quantitative analyses described herein.

     For its  quantitative  evaluations,  Gruntal  calculated  a range of values
using four separate  approaches:  (i) a comparable  company  analysis based upon
comparable  publicly  traded  companies,  (ii) a discounted  cash flow analysis,
(iii) a historical price and volume analysis,  and (iv) a comparable transaction
analysis  based  upon  acquisitions  of  comparable  companies.  In  making  its
determination,  however,  Gruntal reached the conclusion that certain approaches
were more relevant and represented more direct comparability.

     Qualitative Considerations.  In addition to quantitative analyses discussed
below,  Gruntal  considered  a number  of  qualitative  factors  related  to the
Company. Among the qualitative factors relating to the Company: (i) for the past
two fiscal  years the  Company  has  experienced  significant  operating  losses
primarily due to (a) the entry into the market of  competition  for two products
where  the  Company  had  previously  been the sole  generic  manufacturer,  (b)
industry wide pricing pressures on immediate release generic drug products,  and
(c) the lack of new product  approvals;  (ii) the  Company's  near-term  product
pipeline  lacks any  significant  revenue  or high  margin  products;  (iii) the
current  weak balance  sheet and  projected  continued  operating  losses,  on a
stand-alone  basis,  limits the  Company's  ability to develop and introduce new
products; (iv) the Company has few significant non-operating assets to divest in
order to generate

                                       22

<PAGE>



cash to fund operations;  (v) the Company went through a restructuring in fiscal
1997 to stem losses without providing any significant  short-term  impact;  (vi)
General  Electric Credit  Corporation,  the Company's  lender,  waived events of
default on three  occasions,  in fiscal year 1997; and (vii) management has held
discussions  over time with many  generic  drug  companies  in the  industry  to
explore strategic  alternatives and no known alternative  strategic  proposal is
pending at a higher price.

     Among the qualitative  factors  relating to the strategic  alliance between
the  Company  and Merck  KGaA,  Gruntal  noted that (i) a Merck KGaA  investment
provides  capital for the  Company to support  and grow its current  operations;
(ii) Gruntal believes an institutional equity private placement would be done at
a discount  to the  market and would not  provide  near-term  products  or other
operating  synergies  provided by the Merck KGaA  transaction;  (iii) management
believes  that Merck KGaA  provides an  immediate  short and  long-term  product
pipeline  which would take a significant  amount of time and money to internally
develop;  (iv) Company  management  believes  that the  transaction  provides an
opportunity to achieve distribution,  manufacturing and development efficiencies
and/or synergies;  (v) management  believes that the Merck KGaA relationship may
enable  the  Company to respond  more  fully to the  competitive  demands of the
rapidly  consolidating  generic drug industry;  (vi) the Distribution  Agreement
broadens the Company's  existing generic product line and significantly  adds to
its near and long-term product pipeline;  (vii) Company management believes that
the Company and Merck KGaA may realize  increased  product  innovation  from the
combination  of their  respective  research and  development  activities  in the
generic drug areas;  (viii) a significant  capital/product  infusion  allows the
Company shareholders to retain future upside in any stock appreciation; and (ix)
the proposed structure preserves the Company's substantial federal net operating
loss carryforward.

     Comparable  Company  Analysis.  Using publicly  available  information  and
information   provided  by  Company   management,   Gruntal  compared   selected
historical,  current and projected  operating and financial data, stock data and
financial ratios for the Company with certain data from selected publicly traded
companies  engaged  primarily in the generic  pharmaceutical  business  that, in
Gruntal's judgment,  were most closely comparable to the Company.  The companies
selected   were:   Alpharma,   Inc.   Copley   Pharmaceutical,   Inc.,   Duramed
Pharmaceuticals, Inc. and IVAX Corporation (the "Comparable Companies"). Gruntal
reviewed,  among other things, the following data with respect to the Comparable
Companies:  (i) operating statement data, including latest 12 months ("LTM") net
revenues;  (ii) LTM  operating  cash flow ("LTM  EBITDA");  (iii) LTM  operating
income ("LTM EBIT");  (iv) LTM net income;  (v) estimated 1998 net income;  (vi)
estimated 1999 net income; and (vii) selected balance sheet data.  Estimated net
income for 1998 and 1999 for Comparable Companies,  was based on median earnings
per share for 1998 and 1999  forecasted by the  Institutional  Brokers  Estimate
System ("IBES")  multiplied by the fully diluted shares  outstanding.  Utilizing
this  information,  Gruntal  calculated  a range  of  market  multiples  for the
Comparable  Companies by dividing the  "Enterprise  Value"  (total common shares
outstanding  multiplied  by closing  market price per share on March 23, 1998 or
"Market Equity Value",  plus total debt and preferred stock, minus cash and cash
equivalents) for each Comparable Company by, among other things,  such company's
LTM  net  revenues,  LTM  EBITDA  and  LTM  EBIT,  and by  dividing  each of the
Comparable  Company's Market Equity Value by, among other things,  the company's
LTM net income,  and  estimated  1998 and 1999 net incomes.  For the  Comparable
Companies:  (i) the LTM net  revenue  multiples  ranged  from 0.9x to 2.8x (1.6x
mean);  (ii) the LTM EBITDA  multiples  ranged from 11.2x to 12.8x (12.0x mean);
(iii) the LTM EBIT multiples  ranged from 18.6x to 48.2x (33.4x mean);  (iv) the
LTM net income  multiples  ranged from 34.9x to 237.5x  (136.2x  mean);  (v) the
estimated  1998 net income  multiples  ranged from 24.7x to 35.0x (29.9x  mean);
(vi) the estimated 1999 net income  multiples  ranged from 19.6x to 35.0x (25.3x
mean);  and (vii)  [the book  value  multiples  ranged  from 1.3x to 5.5x  (2.8x
mean)].

     Due to the lack of current  earnings and cash flow and forecasted  earnings
of the  Company,  Gruntal  focused its  analysis  on  Enterprise  Value/LTM  net
revenues multiple. Gruntal derived an Enterprise Value/LTM net revenues multiple
range of 0.9x to 1.0x as the high end of this range which is  approximately  the
low end of the  Comparable  Companies  range (0.9x to 2.8x).  This low  multiple
range (as  compared  to the  Comparable  Companies)  was used to reflect  that a
portion  of the  Company's  revenue  is derived  from low  margin  products  and
products distributed but not

                                       23

<PAGE>



manufactured  by the Company and that the Company's  products have lower margins
than the Comparable Companies' products.

     Based on a price of $2.00 per share for the  Common  Stock,  the  Company's
implied LTM net revenue multiple, calculated on the same basis as the Comparable
Companies, was 0.9x.

     Because  of the  inherent  differences  in the  business,  operations,  and
prospects of the Company and the  businesses,  operations  and  prospects of the
Company's  Comparable  Companies,  Gruntal believes it was inappropriate to, and
therefore did not, rely solely on the quantitative results of the analysis,  but
rather  also made  qualitative  judgments  concerning  differences  between  the
financial  and  operating   characteristics  and  prospects  of  the  Comparable
Companies that would affect the public trading values of each as compared to the
Company.

     Comparable Transaction Analysis. Gruntal also was limited in its ability to
perform a  Comparable  Transaction  Analysis  of the  Company due to the lack of
minority investment  transactions for which valuation data is publicly available
involving companies which are closely comparable to the Company on an operating,
product and financial basis. Furthermore,  eight of the 10 transactions reviewed
by Gruntal were mergers or sale of a majority  interest.  Of the  remaining  two
transactions,  one was  pending and had limited  public data  available  and the
second  transaction  represented the remaining minority purchase by the majority
owner.

     Gruntal  reviewed  selected  publicly-available  financial data,  including
Enterprise  Value (at the effective  date of the  transaction)  to net revenues,
Enterprise Value to EBITDA, Enterprise Value to EBIT, and Market Equity Value to
net  income,  regarding  10  acquisitions  of  selected  generic  pharmaceutical
companies.  The 10 transactions  selected,  which took place between December 2,
1992 and February 10, 1998,  were as follows:  (i) the  acquisition  of Biocraft
Laboratories,  Inc. by Teva Pharmaceutical  Industries;  (ii) the acquisition of
Marsam  Pharmaceuticals,  Inc.  by  Schein  Pharmaceuticals,   Inc.,  (iii)  the
acquisition of Circa Pharmaceuticals, Inc. by Watson Pharmaceuticals, Inc.; (iv)
the acquisition of Royce Laboratories, Inc. by Watson Pharmaceuticals, Inc.; (v)
the acquisition of Zenith Laboratories, Inc. by IVAX Corp., (vi) the acquisition
of  Hi-Tech  Pharmacal  Co.,  Inc.  by Circa  Pharmaceuticals,  Inc.,  (vii) the
acquisition of McGaw,  Inc. by IVAX Corp.;  (viii) the acquisition of a majority
interest in Copley  Pharmaceutical  Inc.  by Hoechst  Celanese  Corp.;  (ix) the
acquisition  of the remaining  minority  interest not already owned in Faulding,
Inc. by FH Faulding & Co. Ltd.; and (x) the  acquisition of a minority  interest
in Halsey  Drug Co. by Galen  Associates  which is  pending  completion  and has
limited financial data available.

     The  analysis  considered  the  multiples  of  each  of the  aforementioned
selected data points based upon the selected transactions. As in the case of the
Comparable Companies Analysis, the lack of current earnings and cash flow pose a
potential  barrier to  deriving a  meaningful  valuation.  Gruntal  focused  its
analysis on  Enterprise  Value/LTM  net revenues  multiple.  Gruntal  derived an
Enterprise Value/LTM net revenues multiple of approximately 1.4x as the high end
of this range which is approximately  the low end of the Comparable  Transaction
Analysis range (1.4x to 5.4x). As in the Comparable Companies Analysis, this low
multiple range (as compared to the comparable  transactions) was used to reflect
that a portion of the Company's  revenue is derived from low margin products and
products distributed but not manufactured by the Company.

     Based on a price of $2.00 per share for the  Common  Stock,  the  Company's
implied LTM net revenue multiple, calculated on the same basis as the Comparable
Companies, was 0.9x.

     None of such acquisitions,  however,  took place under market conditions or
competitive  circumstances  that  were  directly  comparable  to  those  of  the
acquisition of a minority interest in the Company by Merck KGaA, and each of the
acquired  companies  is  distinguishable  from the Company in certain  respects.
Accordingly,  an analysis of the results for the  foregoing is not  mathematical
nor necessarily precise;  rather it involves complex  consideration and judgment
concerning  differences in financial and operating  characteristics of companies
and other factors that could affect results.  In particular,  Gruntal considered
the strategic fit of the corporate alliance between the Company and Merck

                                       24

<PAGE>



KGaA,  the  Company's  current  product  mix and product  pipeline,  the product
pipeline  offered by Merck KGaA and the  proceeds  from the  transaction.  These
qualitative  judgements were utilized to confirm the findings based on Gruntal's
quantitative  analysis.  These  qualitative  judgments  do not lead to  specific
conclusions  regarding the transaction value or multiples,  but rather were part
of Gruntal's evaluation.

     Discounted Cash Flow Analyses.  Gruntal  performed two discounted cash flow
("DCF")  analyses,  one for the  Company  on a  stand-alone  basis and the other
including Merck KGaA' s Distribution  Agreement to reflect the potential  future
benefit of the strategic  alliance over and above the infusion of capital.  Both
analyses  were  based  on  four-year  projections  using  financial  information
provided by the  Company's  management  for the years ending  September 30, 1998
through  September 30, 2001.  For the two DCF analyses,  Gruntal  discounted the
projected  unleveraged free cash flows (earnings before interest and taxes, plus
after-tax interest expense and depreciation and amortization, less change in net
working capital and less capital  expenditure) for the respective four years and
the terminal  value  (calculated  as a multiple of EBIT).  From this  Enterprise
Value,  Gruntal  subtracted  all debt  obligations  appearing  on the  Company's
balance  sheet at December 27, 1997,  and added the cash balance on such balance
sheet to arrive at an implied equity value ("Equity Value").  The terminal value
was computed by applying multiples ranging from 12.0x to 16.0x to the forecasted
EBIT of the last year projected.  Gruntal applied a discount rate of 30.0% based
on its estimates of the  Company's  weighted  average cost of capital.  Further,
Gruntal performed sensitivity analyses to understand the effects on Equity Value
from changes in the discount rate and the terminal value.  Based on management's
four-year  projections  for the fiscal years ending  September  30, 1998 through
September  30, 2001,  the implied  equity  value for the Company  divided by its
fully  diluted  shares  outstanding  rendered an implied  equity value per share
("Implied Equity Value Per Share").

     Because of the  Company's  historical  and current lack of earnings and the
degree of uncertainty  surrounding  future  earnings,  Gruntal  assigned greater
relevance to the scenarios where the terminal value was  discounted.  Due to the
high  proportion of value  contribution  associated  with the terminal  value, a
sensitivity  analysis was  performed  assuming  the terminal  value was 20.0% or
50.0% of the forecasted  terminal value. With these changes,  the Implied Equity
Value per share for the  Company on a  stand-alone  basis  ranged from $0.04 per
share  to  $2.31  per  share.  The  DCF  analysis   incorporating  Merck  KGaA's
Distribution  Agreement  offered an Implied  Equity  Value per share that ranged
from $1.58 per share to $4.63 per share assuming the terminal value was 20.0% or
50.0% of the forecasted terminal value.  Therefore,  the DCF analysis showed the
Implied Equity Value Per Share rose as a result of the Distribution Agreement.

     Historical Price and Volume  Analysis.  Gruntal reviewed the weekly closing
price and volume of the Common Stock during the four, eight and 12-month periods
and the three and five-year  periods  ending March 20, 1998, as well as reviewed
daily closing price and volume during the one-year period ending March 23, 1998.
Gruntal also indexed the Company's  stock  performance  over the one-year period
against  an index of the  stock  prices  over  such  periods  of the  Comparable
Companies.  Gruntal noted that on an indexed basis over a one-year  period,  the
Company  performed below the Comparable  Company index.  Gruntal also tested the
frequency  distribution for price sensitivity of the Common Stock. Gruntal noted
that the Company experienced  significant  volatility and a net decline in stock
price  during the  12-months  ended March 20,  l998,  largely as a result of the
competitive  market  environment  for new drugs in the generic drug industry and
continued  operating  losses by the Company.  The high, low and average  closing
prices for the Common  Stock for the  12-month  period ended March 23, 1998 were
$3.75, $1.13 and $2.31,  respectively.  The high, low and average closing prices
for the Common Stock for the six-month  period ended March 23, 1998, were $2.75,
$1.13 and $2.07,  respectively.  Gruntal noted the assumed  transaction price of
$2.00 per  share  represents  a slight  discount  to the six month and  12-month
average share price.  Gruntal  determined that over the last four,  eight and 12
months approximately 56.0%, 38.0% and 28.9%,  respectively,  of the Common Stock
traded below $2.00 per share.  In  addition,  Gruntal  observed  that the Common
Stock did not trade higher than $2.00 between  November 17, 1997 and January 16,
1998.

     Based on Gruntal's quantitative and qualitative analysis,  Gruntal believes
as described above that the Proposed Transaction is fair, from a financial point
of view, to the Company.

                                       25

<PAGE>




      The  affirmative  vote of the  holders  of a majority  of the  outstanding
shares of Common Stock is required for approval of Proposal II.

     IF PROPOSAL II IS NOT APPROVED,  IF THE STOCK PURCHASE AGREEMENT TERMINATES
OR IF THE PROPOSED  TRANSACTION  IS NOT  CONSUMMATED  FOR ANY OTHER REASON,  THE
ELECTION OF THE SEVEN  NOMINEES AS DIRECTORS AS DESCRIBED IN PROPOSAL I WILL NOT
BECOME  EFFECTIVE AND THE COMPANY'S  CERTIFICATE  OF  INCORPORATION  WILL NOT BE
AMENDED AS DESCRIBED IN PROPOSAL III,  EVEN IF EITHER OR BOTH OF SUCH  PROPOSALS
ARE APPROVED BY THE COMPANY'S SHAREHOLDERS AT THE MEETING. If Proposal II is not
approved by the shareholders at the Meeting,  each of Lipha and the Company will
have a right to terminate the Stock Purchase Agreement. In such event, it is the
present  intention of the Company to discuss with Merck KGaA and its  affiliates
entering  into  alternative   transactions,   subject  to  applicable  laws  and
regulations.  No  specific  alternative  transactions  are  currently  proposed.
FURTHER,  IF  PROPOSAL  II IS  APPROVED  BY THE  COMPANY'S  SHAREHOLDERS  AT THE
MEETING,  BUT EITHER OR BOTH OF PROPOSAL I AND  PROPOSAL III ARE NOT APPROVED BY
THE COMPANY'S  SHAREHOLDERS AT THE MEETING OR IF THE STOCK PURCHASE AGREEMENT IS
TERMINATED, THE COMPANY WILL NOT CONSUMMATE THE STOCK PURCHASE AGREEMENT AND THE
ELECTION OF DIRECTORS AS DESCRIBED IN PROPOSAL I WILL NOT BECOME  EFFECTIVE  AND
THE  COMPANY'S  CERTIFICATE  OF  AMENDMENT  WILL NOT BE AMENDED AS  DESCRIBED IN
PROPOSAL III.

     THE BOARD OF DIRECTORS UNANIMOUSLY  RECOMMENDS A VOTE "FOR" THE APPROVAL OF
PROPOSAL II.


                                  PROPOSAL III

                       INCREASE IN AUTHORIZED COMMON STOCK

     The  Board  has  proposed  an  amendment  to  Article  IV of the  Company's
Certificate of Incorporation  to increase the authorized  number of Common Stock
from 60,000,000 to 90,000,000 shares upon the consummation of the Stock Purchase
Agreement (the "Common Stock Amendment"). Unless the authorized number of shares
of Common Stock is increased,  the Company will not have a sufficient  number of
authorized shares of Common Stock to consummate the Proposed Transaction.

      As of April 30, 1998,  [18,886,098] shares of Common Stock were issued and
outstanding. In addition, [3,507,012] shares of Common Stock were reserved as of
such date for future issuance upon the exercise of outstanding stock options and
warrants,  for future  grants of stock options and other equity awards under the
Company's  stock option plans and under the Company's  employee  stock  purchase
plan.  Further,  there is outstanding one stock purchase right for each share of
Common  Stock  outstanding.  There is also one right  reserved for each share of
Common Stock  reserved for issuance upon exercise of  outstanding  stock options
and warrants. The rights, issued pursuant to the Rights Agreement,  dated August
8, 1991,  between the  Company and First City  Transfer  Company,  as  successor
rights agent,  entitle the holder to purchase one share of Common Stock for each
right held, in certain circumstances. Accordingly, [22,393,110] shares of Common
Stock are presently  reserved to cover potential  exercise of the rights. If the
Proposed  Transaction  is  approved,  10,400,000  shares of Common Stock will be
issued  to Lipha and  1,171,040  shares of Common  Stock  will be  reserved  for
potential exercise of the Options of Merck KGaA and Genpharm,  and an additional
11,571,040  stock purchase  rights will be issued or subject to issuance to such
entities  requiring a reservation of a corresponding  number of shares of Common
Stock.

     The purpose of the proposed Common Stock Amendment is to provide additional
shares of Common Stock for the consummation of the Proposed  Transaction and for
other valid  corporate  purposes  without  further  shareholder  approval unless
required by applicable law or regulation.  Those corporate purposes may include,
among other things, offerings to raise additional capital,  management incentive
and  employee  benefit  plans,  expansion  of  the  Company's  business  through
investments  or  acquisitions,  stock  dividends,  stock  splits,  and new stock
inventive plans. The

                                       26

<PAGE>



Company has no present plans, understandings,  or agreements for the issuance or
use of  additional  Common  Stock,  other than in  connection  with the Proposed
Transaction and options, warrants and rights outstanding or to be granted in the
ordinary course of business. The Board believes the Common Stock Amendment is in
the best  interests  of the  Company  because it will help  effect the  Proposed
Transaction and the Board  thereafter also will have the flexibility to promptly
issue  additional   shares  of  Common  Stock  when  the  need  and  appropriate
opportunities   arise.  The  issuance  of  additional  shares  of  Common  Stock
authorized   under  the  proposed   Common  Stock  Amendment  would  reduce  the
proportionate  voting  interest  in the  Company  held by current  shareholders.
Current holders of Common Stock have no preemptive rights.

     Although  the Board has no present  intention  of doing so,  the  Company's
authorized but unissued Common Stock could be issued in one or more transactions
which would make a takeover of the Company  more  difficult  or costly.  Issuing
additional  shares of Common  Stock in the future  could also have the effect of
diluting the ownership of persons seeking to obtain control of the Company.  The
Common Stock Amendment is not intended to deter future takeovers of the Company,
nor is the Board currently proposing to shareholders any anti-takeover measures.

     The affirmative vote of the holders of a majority of the outstanding shares
of Common Stock is required for approval of Proposal III.

     IF PROPOSAL  III IS NOT  APPROVED,  THE  ELECTION OF THE SEVEN  NOMINEES AS
DIRECTORS  AS DESCRIBED  IN PROPOSAL I WILL NOT BECOME  EFFECTIVE  AND THE STOCK
SALE AND OPTION  ISSUANCE AS  DESCRIBED  IN PROPOSAL II WILL NOT OCCUR,  EVEN IF
EITHER OR BOTH OF SUCH PROPOSALS ARE APPROVED BY THE COMPANY'S  SHAREHOLDERS  AT
THE MEETING.  FURTHER, IF PROPOSAL III IS APPROVED BY THE COMPANY'S SHAREHOLDERS
AT THE  MEETING,  BUT  EITHER  OR BOTH OF  PROPOSAL  I AND  PROPOSAL  II ARE NOT
APPROVED BY THE COMPANY'S  SHAREHOLDERS  AT THE MEETING OR IF THE STOCK PURCHASE
AGREEMENT IS  TERMINATED,  THE COMPANY WILL NOT  CONSUMMATE  THE STOCK  PURCHASE
AGREEMENT  AND THE  ELECTION OF  DIRECTORS  AS  DESCRIBED IN PROPOSAL I WILL NOT
BECOME EFFECTIVE AND THE COMPANY'S  CERTIFICATE OF AMENDMENT WILL NOT BE AMENDED
AS DESCRIBED IN THIS PROPOSAL III.

     THE BOARD OF DIRECTORS UNANIMOUSLY  RECOMMENDS A VOTE "FOR" THE APPROVAL OF
PROPOSAL III.


                                   PROPOSAL IV

                        APPROVAL AND ADOPTION OF THE 1997
                           DIRECTORS STOCK OPTION PLAN

General
- -------

     At the  Meeting,  the holders of Common  Stock will be asked to vote upon a
proposal to approve and adopt the  Company's  1997  Directors  Stock Option Plan
(the  "Directors  Plan").  On October 28, 1997, the Board approved the Directors
Plan,  subject  to the  approval  and  adoption  of the  Directors  Plan  by the
shareholders of the Company not later than October 28, 1998. The purposes of the
Directors Plan are to advance the interests of the Company by affording eligible
directors an  opportunity  and  additional  incentive  to acquire,  maintain and
increase  their  ownership  interests  in  the  Company  and  thereby  encourage
continued  service.  In connection  with the adoption of the Directors Plan, the
Board  decided to  terminate  the 1995  Directors  Stock  Option Plan subject to
approval of the  Directors  Plan at the Meeting.  The approval of the  Directors
Plan will have no effect upon the  Company's  1989  Directors  Stock Option Plan
(the "1989 Plan"), except that current non-employee directors will surrender for
cancellation  options  issued under the 1989 Plan for an equal number of options
under the Directors Plan as described below. See "-Summary of Directors Plan."


                                       27

<PAGE>

Summary of Directors Plan
- -------------------------

     The Company has  reserved  for issuance  under the  Directors  Plan 500,000
shares of Common Stock.  Options granted under the Directors Plan may be granted
only to  directors  of the  Company  who are not  employees  of the  Company  or
otherwise  eligible  to  receive  options  under any other  plan  adopted by the
Company (each, an "Eligible Director"). Such options do not qualify as incentive
stock options within the meaning of Section 422 of the Code.

     If approved by the Company's shareholders,  the Directors Plan provides for
automatic  annual  grants of stock  options to purchase  5,000  shares of Common
Stock to each Eligible  Director on the date of the director's  initial election
to the Board and on each succeeding date that the  shareholders  elect directors
at a meeting (the "Date of Grant").  No Eligible Director will receive more than
one  automatic  annual  grant in a year.  Further,  Eligible  Directors  will be
entitled  to  receive  on each Date of Grant an  additional  grant of options to
purchase  6,000 shares of Common Stock as long as the Eligible  Director owns at
least 2,500 shares of issued Common Stock (the "Additional  Grant"). In order to
receive  an  Additional  Grant on any  subsequent  Date of Grant,  the  Eligible
Director must own at least an additional 2,500 shares of issued Common Stock for
each  Date  of  Grant.  Subject  to  approval  of  the  Directors  Plan  by  the
shareholders  at the Meeting,  all current  Eligible  Directors  will receive an
option to purchase  10,000  shares of Common  Stock for each year such  director
served on the Board, in exchange for the surrender for cancellation of all stock
options  then held by the  Eligible  Director,  but in no case  will such  grant
exceed the number of stock options surrendered. Also, current Eligible Directors
will receive an option to purchase an additional 6,000 shares of Common Stock if
such Director  owned at least 2,500 shares of Common Stock on April 1, 1998. The
exercise price for options granted under the Directors Plan will be, in general,
the closing sale price of the Common Stock on the date of grant.

      Any option  granted under the Directors  Plan will become  exercisable  in
full on the first  anniversary of the date of grant,  provided that the Eligible
Director  has not been removed for "cause" as a member of the Board of Directors
on or prior to the first  anniversary  of the date of the  grant.  To the extent
options granted under the Directors Plan become  exercisable,  such options will
remain  exercisable  until the tenth  anniversary  of the date of grant and will
remain  exercisable  regardless  of whether the Eligible  Director  continues to
serve as a member of the Board. If an Eligible Director fails to continue to own
a number of shares of Common  Stock  equal to the number of shares  which were a
condition  to  the   Additional   Grant(s),   such   Additional   Grant(s)  will
automatically terminate.

     If an  unexercised  option  expires or terminates (in whole or in part) for
any reason,  the shares allocable to the unexercised  portion of the option will
be  available  for  future  grants of  options  under the  Directors  Plan.  The
aggregate  number of shares of Common Stock as to which  options may be granted,
the number of shares  covered by each option and the option  exercise price will
be adjusted  in the event of stock  splits,  stock  dividends  or other  capital
adjustments.

     Pursuant to its terms,  the  Directors  Plan will  terminate on October 28,
2008,  and no options  may be granted  after that date.  The  provisions  of the
Directors  Plan,  however,  will  continue  thereafter  to  govern  all  options
previously granted, until the exercise,  expiration or cancellation thereof. The
Board may,  however,  terminate  the  Directors  Plan at an earlier date and may
modify or amend the Directors Plan from time to time.

     No option is  transferable  other than by will or the laws of  descent  and
distribution  or by a qualified  domestic  relations  order as defined under the
Code and no option may be exercised by anyone  other than the  optionee,  except
that if the optionee dies or becomes incapacitated,  the option may be exercised
by the optionee's estate,  legal  representative or beneficiary,  subject to all
the other terms of the Directors  Plan. The Directors Plan will be  administered
by the entire Board.

     All of the current  directors of the  Company,  and all of the nominees for
election as directors, other than Mr. Sawyer and Dr. Neirinckx, will be eligible
to receive options under the Directors Plan. In connection with, and subject to,
the consummation of the Stock Purchase Agreement, all current Eligible Directors
have agreed not to exercise any

                                       28
<PAGE>



stock options,  including stock options  acquired under the Directors Plan (even
though the stock  options may be otherwise  exercisable)  during the three years
following the Closing Date,  except that  installments of one-third of the stock
options may be exercised  on the first,  second and third  anniversaries  of the
Closing Date.

     The  foregoing is a summary of the  Directors  Plan.  This summary does not
purport to be  complete,  and is  qualified  in its entirety by reference to the
text of the  Directors  Plan. A copy of the  Directors  Plan is  available  upon
written request from the Company's Secretary at no charge.

New Plan Benefits
- -----------------

     The  following  table sets forth the dollar value of benefits and number of
shares underlying options if the Directors Plan is approved.

Name and Position                      Dollar Value            Number of Options
- -----------------                      ------------            -----------------

Kenneth I Sawyer, Chairman                   --                          --
 and Chief Executive Officer

Dennis J. O'Connor                           --                          --
Vice President, Chief
 Financial officer and Secretary

Executive Group                              --                          --

Non-Executive Director Group              $[    ](1)                  260,000

Non-Executive Officers                       --                          --
 Employee Group

- ------------------------------------

(1) Represents the total net realizable value, after payment of the stock option
exercise  price,  if grants of stock options made under the Directors  Plan were
exercised  on April 30,  1998.  Such stock option  grants are  conditioned  upon
shareholder approval of the Directors Plan at the Meeting.

      The  closing  price of a share  of  Common  Stock  on The New  York  Stock
Exchange on May __, 1998 was $_____.


Certain Federal Income Tax Consequences
- ---------------------------------------

     The following is a brief summary of certain  Federal  income tax aspects of
stock  options to be granted  under the  Directors  Plan based upon the Code and
other statutes,  regulations and  interpretations  in effect on the date of this
Proxy  Statement.  The  summary is not  intended to be  exhaustive  and does not
include state, local or foreign income or other tax consequences.

     Any option  granted under the Directors  Plan is not intended to qualify as
an "incentive stock option", as that term is defined in Section 422 of the Code.
Neither  the option  holder nor the Company  will incur any  Federal  income tax
consequences  upon the grant of an option under the Directors  Plan.  Generally,
the option holder will recognize, on the date of exercise, ordinary compensation
income in an amount equal to the excess, if any, of the fair market value of the
shares of Common Stock on the date of exercise over the exercise price thereof.


                                       29

<PAGE>

     On a subsequent sale of any shares obtained upon the exercise of an option,
the participant will recognize capital gain or loss equal to the difference,  if
any, between the amount realized and his or her tax basis in the shares. The tax
basis of the shares, for purposes of computing taxable gain or loss, will be the
sum of the exercise  price and the amount of ordinary  income  recognized on the
date of exercise.

     For Federal  income tax  purposes,  the Company is generally  entitled to a
deduction in an amount equal to the ordinary  compensation  income recognized by
the option  holder,  to the extent  that such  income is  considered  reasonable
compensation  under the Code.  Generally,  the Company will be entitled to claim
such  deduction in the fiscal year  containing the last day of the calendar year
in which the option is exercised.

     The Company  believes  the  adoption of the  Directors  Plan is in the best
interests  of the  Company  and  its  shareholders.  The  affirmative  vote of a
majority of the votes cast in person or by proxy at the Meeting is required  for
approval of the Directors Plan.

     THE BOARD OF DIRECTORS UNANIMOUSLY  RECOMMENDS A VOTE "FOR" THE APPROVAL OF
PROPOSAL IV.



                              INDEPENDENT AUDITORS

     The  Board  has  selected  the firm of  Arthur  Andersen  LLP,  independent
certified public  accountants,  to act as independent public accountants for the
Company for the 1998 fiscal year. Arthur Andersen LLP has acted in such capacity
for the Company from the fiscal year ended September 30, 1995. A  representative
of  Arthur  Andersen  LLP  is  expected  to be  present  at  the  Meeting,  such
representative  will have the  opportunity  to make a statement  if he or she so
desires and is expected to be available to respond to appropriate questions.



                                  OTHER MATTERS

     At the date of this  Proxy  Statement,  the Board has no  knowledge  of any
business which will be presented for consideration at the Meeting, other than as
described  above. If any other matter or matters are properly brought before the
Meeting or any adjournment(s)  thereof, it is the intention of the persons named
in the accompanying  form of proxy to vote proxies on such matters in accordance
with their judgment.


                       SUBMISSION OF SHAREHOLDER PROPOSALS

     Any proposal  which is intended to be presented by any Company  shareholder
for  action at the 1999  Annual  Meeting of  Shareholders  must be  received  in
writing by the Secretary of the Company,  at One Ram Ridge Road,  Spring Valley,
New York 10977,  not later than  December 31, 1998 in order for such proposal to
be considered for inclusion in the proxy statement and form of proxy relating to
the 1999 Annual Meeting of Shareholders.

                                    By Order of the Board of Directors


                                    Dennis J. O'Connor
                                    Secretary

Dated: May __, 1998

                                       30

<PAGE>



                                    Exhibit A





                            Stock Purchase Agreement

                                      

<PAGE>


     STOCK  PURCHASE  AGREEMENT,  dated March 25, 1998,  between  Pharmaceutical
Resources,  Inc., a New Jersey  corporation  (the  "Company"),  whose  principal
offices are located at One Ram Ridge Road,  Spring Valley,  New York 10977,  and
Lipha Americas, Inc., a Delaware corporation (the "Purchaser"),  whose principal
offices are located at 1209 Orange Street, Wilmington, Delaware 19801.

     WHEREAS,  the Company  desires to issue and sell to the Purchaser,  and the
Purchaser  desires to purchase from the Company,  10,400,000  restricted  shares
(the "Shares") of the Company's  common stock, par value $.01 per share ("Common
Stock");

     WHEREAS,  concurrently  with the execution and delivery of this  Agreement,
Merck KGaA, an affiliate of the  Purchaser  ("Merck"),  and Clal  Pharmaceutical
Industries,  Ltd. ("Clal") are entering into a stock purchase agreement pursuant
to which  Merck (or its  designees)  will,  subject to the terms and  conditions
thereof, purchase from Clal certain shares of Common Stock beneficially owned by
Clal  (the  "Clal  Stock  Purchase   Agreement"),   the  consummation  of  which
transaction  shall  occur at the time of the  consummation  of the  transactions
contemplated by this Agreement;

     WHEREAS, concurrently with the execution and delivery of this Agreement and
as an  inducement to the Company to enter into this  Agreement,  the Company and
Genpharm, Inc. ("Genpharm"),  an affiliate of the Purchaser, are entering into a
distribution  agreement  pursuant  to  which,  and  subject  to  the  conditions
contained  therein,  the Company shall distribute  certain products of Genpharm,
substantially in the form of Exhibit A hereto (the "Distribution Agreement");

     WHEREAS, at the Closing (as defined in Section 1.2 hereof), the Company and
Genpharm and Merck shall enter into  services  agreements  substantially  in the
form  of  Exhibit  B  hereto  (collectively,  the  "Services  Agreements";  each
individually  referred  to herein as a "Services  Agreement")  pursuant to which
Merck and Genpharm shall render certain significant  services to the Company, in
consideration  of, among other things,  the issuance by the Company to Merck and
Genpharm of certain five-year stock options  exercisable  commencing in the year
2001 to acquire up to an  aggregate  of  1,171,040  additional  shares of Common
Stock  (the  "Option  Shares"),  substantially  in the form of  Exhibit C hereto
(collectively,  the  "Options";  each  individually  referred  to  herein  as an
"Option");

     WHEREAS,  the Company has  received a fairness  opinion from Gruntal & Co.,
L.L.C.  ("Gruntal") to the effect that the Purchase Price (as defined in Section
1.1  hereof)  and  the   transactions   contemplated  by  this  Agreement,   the
Distribution Agreement,  the Services Agreements and the Options are, taken as a
whole, from a financial point of view, fair to the holders of Common Stock;

     WHEREAS,  the  Company's  Board of Directors has approved the execution and
performance  of  this  Agreement,   the  Distribution  Agreement,  the  Services
Agreements  and  the  Options,   and  has  determined   that  the   transactions
contemplated hereby and thereby are in the best interests of the Company and its
shareholders; and

     WHEREAS,  the Company and the  Purchaser  desire to set forth their  mutual
agreements  with  respect to the sale and  purchase  of the Shares and as to the
other matters set forth herein.

                                        A-1

<PAGE>



         NOW,  THEREFORE,  in  consideration  of the  premises and of the mutual
agreements set forth herein, the parties hereto agree as follows:

         SECTION 1.  Closing Transactions.

         1.1 Purchase and Sale of Shares. At the Closing, the Company shall sell
to the  Purchaser,  and the  Purchaser  shall,  or shall cause its  designee to,
purchase  from the  Company,  upon  the  terms  and  subject  to the  conditions
hereinafter  set forth,  the  Shares for an  aggregate  cash  purchase  price of
$20,800,000 (the "Purchase Price"), or $2.00 per Share.

         1.2 The Closing.  The closing of the transactions  contemplated by this
Agreement (the "Closing") shall take place at the offices of Hertzog, Calamari &
Gleason,  100 Park Avenue, 23rd Floor, New York, New York, at 10:00 A.M., on the
second  business day following the date on which all of the conditions set forth
in  Sections  4 and 5  hereof  shall  have  been  satisfied  or,  to the  extent
permitted,  waived,  or at such other place, time and/or date as the parties may
agree (the  "Closing  Date");  provided,  that the Closing  Date shall not occur
before June 1, 1998.

     1.3 Closing  Deliveries.  (a) At the Closing,  the Company shall deliver to
the Purchaser, Merck and Genpharm, as applicable:

                           (i) a stock certificate or certificates  representing
         the Shares,  registered  in the name of the  Purchaser  or,  subject to
         Section 13.2 hereof, its designee on the Company's books and containing
         no  legends  other  than as set  forth in  Section  9.2  hereof  and as
         required  under the  Rights  Agreement  (as  defined  in  Section  7.11
         hereof);

                           (ii) a registration  rights agreement,  duly executed
         by the  Company,  substantially  in the form of  Exhibit D hereto  (the
         "Registration Rights Agreement");

                           (iii)    the certificates of officers of the Company 
         referred to in Sections 5.1 and 5.2 hereof;

                           (iv)     the agreements covering the Options, duly 
         executed by the Company;

                           (v)      the opinion of counsel referred to in 
         Section 5.3 hereof;

                           (vi)      the Services Agreements, duly executed by 
         the Company;

                           (vii)     the agreement of the Chairman of the 
         Company referred to in Section 7.10 hereof; and

                           (viii) the agreement of Kenneth Sawyer referred to in
         Section 7.3(e) hereof.


                                        A-2

<PAGE>



         (b) At the Closing, the Purchaser,  Merck and Genpharm,  as applicable,
shall deliver to the Company:

             (i)  the  Purchase  Price,  in  the  form  of a  wire  transfer  of
                  immediately  available  funds to an account  designated by the
                  Company;

             (ii) the  Registration  Rights  Agreement,  duly  executed  by  the
                  Purchaser, Merck and Genpharm;

             (iii)the  certificates of officers of the Purchaser  referred to in
                  Sections 4.1 and 4.2 hereof;

             (iv) the opinion of counsel referred to in Section 4.3 hereof;

             (v)  the Services  Agreements,  duly executed by Merck or Genpharm,
                  as applicable;

             (vi) the agreements covering the Options, duly executed by Merck or
                  Genpharm, as applicable; and

             (vii)the agreement of the Purchaser (and its  Affiliates)  referred
                  to in Section 7.3(e) hereof.

     SECTION 2.  Representations  and  Warranties  of the  Company.  The Company
hereby represents and warrants to the Purchaser as follows:

     2.1 Organization.  Each of the Company, and any corporation with respect to
which the Company owns a majority of the common stock,  or has the power to vote
or direct  the  voting  of  sufficient  securities  to elect a  majority  of the
directors,  or  has  the  power  to  control  or  direct  the  actions  of  such
corporation,  all of which are set forth on Schedule 2.11 hereto  (collectively,
the "Subsidiaries",  each individually referred to herein as a "Subsidiary"), is
a corporation  duly organized,  validly  existing and in good standing under the
laws of the  jurisdiction of its  incorporation,  as set forth on Schedule 2.11.
Each of the Company and its Subsidiaries  has all necessary  corporate power and
authority  to own or lease its  properties  and to conduct  its  business as now
being  conducted.  Each of the Company and its Subsidiaries is duly qualified to
do  business  and  is  in  good  standing  as  a  foreign  corporation  in  each
jurisdiction  in which the  property  owned,  leased or  operated  by it, or the
nature of the  business  conducted  by it,  requires  such  qualification  under
applicable  law, except where the failure to be so qualified would not result in
a Material Adverse Effect (as defined in Section 2.10 hereof).

                                        A-3

<PAGE>

     2.2  Authorization.  The execution,  delivery and, subject to obtaining the
approval (the "Shareholders'  Approval") of the holders of (i) a majority of the
outstanding  shares of Common Stock for the issuance of the Shares, the delivery
of the Options and the  issuance  of the Option  Shares,  (ii) a majority of the
outstanding   shares  of  Common  Stock  for  the  amendment  of  the  Company's
certificate  of  incorporation  in order to  increase  the number of  authorized
shares of Common Stock and (iii) a plurality of the shares of Common Stock voted
at a meeting for the election of the Nominees (as defined in Section 7.3 hereof)
(the preceding clauses (i), (ii) and (iii) to be individually referred to herein
as a "Proposal" and  collectively  as the  "Proposals"),  the performance by the
Company  of this  Agreement,  the other  agreements  referred  to herein and the
transactions  contemplated  hereby and thereby have been duly  authorized by all
requisite corporate action by the Company. This Agreement constitutes,  and each
other  agreement  referred to herein,  upon due  execution  and  delivery,  will
constitute, the valid and binding obligation of the Company, enforceable against
the Company in accordance with its terms,  except as such  enforceability may be
limited by (i)  bankruptcy  laws and other  similar  laws  affecting  creditors'
rights  generally and (ii) general  principles of equity,  regardless of whether
asserted in a proceeding in equity or at law.

     2.3  Non-contravention.  Neither the execution,  delivery or performance of
this Agreement and the other agreements  referred to herein nor the consummation
of the transactions  contemplated  hereby or thereby will,  subject to obtaining
the Shareholders' Approval,  violate or be in conflict with any provision of the
certificate  of  incorporation  or  by-laws  of  any  of  the  Company  and  its
Subsidiaries; subject to obtaining the Shareholders' Approval, and except as set
forth on Schedule 2.3 hereto,  violate or be in conflict with any material note,
bond, lease, mortgage,  indenture,  license,  contract,  commitment,  franchise,
permit, instrument or other material agreement or obligation to which any of the
Company and its  Subsidiaries is a party or by which it is bound;  violate or be
in conflict with any law, judgment,  decree,  order,  regulation or ordinance by
which any of the Company and its Subsidiaries is bound or affected; or result in
the creation or imposition of any liens, charges,  pledges or other encumbrances
("Liens") in favor of any third party upon any property or assets of the Company
and its Subsidiaries.

     2.4  Authorization  of the Shares.  Subject to obtaining the  Shareholders'
Approval, all corporate action necessary for the issuance,  sale and delivery of
the Shares has been taken by the Company  and,  when issued and  delivered  upon
payment in full of the Purchase Price, the Shares will be validly issued,  fully
paid  and  nonassessable,  free  and  clear  of any and all  Liens.  Subject  to
obtaining  the  Shareholders'  Approval,  the  Option  Shares  will  be  validly
authorized  for  issuance  and,  when and if issued upon  payment in full of the
exercise  price  for the  Option  Shares  in  accordance  with the  terms of the
Options, the Option Shares will be validly issued, fully-paid and nonassessable,
free and clear of any and all Liens.

     2.5 Capitalization. The authorized capital stock of the Company consists of
60,000,000  shares of Common Stock, of which no more than 18,923,000  shares are
issued and outstanding as of the date hereof,  and 6,000,000 shares of preferred
stock, par value $.0001 per share, of which no shares are issued and outstanding
as of the date hereof.  The Company holds no treasury  shares.  All  outstanding
shares of Common Stock have been duly and validly  issued and are fully-paid and
nonassessable.  There are no outstanding securities  exchangeable or convertible
into,  or options,  warrants,  or rights to subscribe  for, or to  purchase,  or
commitments to issue, any unissued shares of capital stock of any of the Company
and its Subsidiaries, except as set forth on Schedule 2.5 hereto.

                                        A-4

<PAGE>

     2.6 Reports  Under the Exchange Act.  Since October 1, 1994,  except as set
forth on Schedule  2.6 hereto,  the  Company has filed with the  Securities  and
Exchange  Commission  (the "SEC") in timely  fashion all reports  required to be
filed by the Company pursuant to the Securities Exchange Act of 1934, as amended
(the "Exchange Act") (as such reports may have been amended or supplemented, the
"SEC  Reports").  The Common  Stock is  registered  under  Section  12(b) of the
Exchange Act. As of their respective  filing dates with the SEC, the SEC Reports
did not  contain  any untrue  statement  of a  material  fact or omit to state a
material  fact  required to be stated  therein or necessary in order to make the
statements made therein,  in light of the circumstances in which they were made,
not misleading.

     2.7 No Brokers or Finders. No person, firm or corporation has or will have,
as a result of any act or omission  by any of the Company and its  Subsidiaries,
any right,  interest or valid claim  against the Purchaser or any of the Company
and its Subsidiaries for any commission,  fee or other  compensation as a finder
or broker,  or in any similar  capacity,  other than with respect to the opinion
referred  to in  Section  4.9  hereof  (the  costs of which will be borne by the
Company), in connection with the transactions contemplated by this Agreement.

     2.8  Governmental   Authorizations;   Third-Party  Consents.  No  approval,
consent,  authorization  or other  action by, or notice to or filing  with,  any
governmental  authority or any other person or entity, and no lapse of a waiting
period,  is necessary or required in connection with the execution,  delivery or
performance by the Company of this Agreement,  the other agreements  referred to
herein or the transactions  contemplated hereby or thereby,  except for (i) such
filings  or  approvals  required  pursuant  to the  Hart-Scott-Rodino  Antitrust
Improvements Act of 1976, as amended, and the regulations promulgated thereunder
(the "HSR  Act"),  (ii) such  filings  or  approvals  as may be  required  to be
obtained in connection with the manufacture and sale of products pursuant to the
Distribution Agreement, (iii) the Shareholders' Approval of the Proposals by the
requisite votes, (iv) such filings or approvals  required to list the Shares and
the Option Shares on the New York Stock  Exchange and the Pacific Stock Exchange
and (v) the matters set forth on Schedule 2.8 hereto.

     2.9 Financial  Statements.  The audited financial statements of the Company
included in the  Company's  Annual Report on Form 10-K for the fiscal year ended
September  30,  1997 (the  "Audited  Statements")  and the  unaudited  financial
statements  of the Company  included in the Company's  Quarterly  Report on Form
10-Q for the fiscal quarter ended December 31, 1997 (the "Unaudited Statements")
complied  as to form with the  requirements  of the  Exchange  Act and except as
disclosed  therein or in the  footnotes  thereto and,  except for the absence of
notes  and  subject  to  year-end  adjustments  in the  case  of  the  Unaudited
Statements,  were prepared in accordance with United States  generally  accepted
accounting  principles.  The Audited  Statements  and the  Unaudited  Statements
fairly present, in all material respects,  the consolidated  financial condition
and the  consolidated  results of  operations of the Company as of the dates and
for the periods indicated therein.

     2.10  Absence of Material  Adverse  Effect.  Except as disclosed in the SEC
Reports, since January 1, 1998, the business of the Company and its Subsidiaries
has been operated in the ordinary

                                        A-5

<PAGE>

course and substantially  consistent with past practice.  Since January 1, 1998,
there has been no event or circumstance  resulting in a material  adverse effect
on the properties,  business and assets,  liabilities,  condition  (financial or
otherwise) or operations  of the Company and its  Subsidiaries,  considered as a
whole (a "Material  Adverse  Effect").  There has been no event or circumstance,
since January 1, 1998,  which would  materially  adversely affect the ability of
the Company to perform its obligations under this Agreement, or any of the other
agreements  to  be  entered  into  in  connection  with  this  Agreement,  or to
consummate the transactions contemplated hereby and thereby.

     2.11 Subsidiaries;  Other Equity Interests.  Each Subsidiary of the Company
and each other  person in which the  Company or any of its  Subsidiaries  has an
equity interest is set forth on Schedule 2.11 hereto.  Each Subsidiary is wholly
(100%) owned by the Company.  The authorized,  issued and outstanding  shares of
the capital stock of each Subsidiary, and the record and beneficial ownership of
the outstanding  shares thereof,  is as set forth on Schedule 2.11. There are no
agreements or  arrangements to which any Subsidiary is a party or by which it is
bound for the  redemption,  repurchase or issuance of, and there are no options,
warrants,  puts,  calls or other rights to subscribe for or purchase,  shares of
such Subsidiary's capital stock.

     2.12 No Third-Party Options. Except as contemplated hereby, as set forth on
Schedule 2.12 hereto, or as disclosed in the SEC Reports,  there are no existing
agreements,  contracts,  commitments, options, warrants or rights with, of or to
any person which are binding on the Company or its  Subsidiaries  to acquire any
of the  Company's and its  Subsidiaries'  assets,  properties,  or rights or any
interest  therein  (whether  real,  personal or mixed,  tangible or  intangible,
wherever  located  and  whether  in  the  possession  of  the  Company  and  its
Subsidiaries or any other person), except for those entered into in the ordinary
course of  business  consistent  with past  practice  for the sale of  inventory
and/or which could not  reasonably  be expected to result in a Material  Adverse
Effect.

     2.13 Employee Matters.

     (a)  The  Company  has  delivered  to the  Purchaser  a list of its and its
Subsidiaries' current employees (the "Employees"). This list, attached hereto as
Schedule  2.13(a),  sets forth the current  compensation,  commissions or hourly
rate of pay, date of birth,  date and location of  employment  and job title for
each Employee. Schedule 2.13(a) lists all agreements between the Company and its
Subsidiaries  and  any  Employee(s)  with  respect  to  the  employment  of  any
Employee(s).  Except as set forth on Schedule 2.13(a),  there are no outstanding
loans with outstanding  principal  amounts in excess of $50,000 from the Company
or any of its  Subsidiaries  to any  Employees.  Except as set forth on Schedule
2.13(a),  no Employee is on disability or other leave of absence and the Company
is not  aware of the  intent of any  officer,  executive  employee  or head of a
department  of any of the  Company and its  Subsidiaries  to  terminate  his/her
employment.

     (b) Schedule 2.13(b) hereto lists each "employee  benefit plan", as defined
in Section  3(3) of the Employee  Retirement  Income  Security  Act of 1974,  as
amended ("ERISA"),  whether or not covered by ERISA, that any of the Company and
its Subsidiaries sponsors or has

                                        A-6

<PAGE>

sponsored to which the Company or any of its  Subsidiaries is or has been in the
past three years required to make  contributions,  including without  limitation
any pension,  profit-sharing,  retirement or deferred  compensation  plan,  each
other benefit plan,  policy,  arrangement or practice,  whether  covering one or
more employees,  which provides deferred  compensation,  bonus,  stock purchase,
stock  option,  vacation,  severance,   disability,   hospitalization,   medical
insurance or life insurance payments or benefits and any other material employee
benefit plans,  agreements,  arrangements or  understandings  maintained for the
benefit of the  Employees  or former  employees  of any of the  Company  and its
Subsidiaries  ("Former  Employees")  (collectively,  together  with any  related
trusts, the "Employee Benefit Plans").  Except as set forth on Schedule 2.13(b),
no Employee  Benefit Plan  constitutes a  multi-employer  plan (as defined under
Section  400(a)(3)  of  ERISA).  Except as set forth on  Schedule  2.13(b),  all
participants in the Employee Benefit Plans are Employees or Former Employees (or
their dependents or beneficiaries). The Company has previously delivered or made
available  to the  Purchaser  true  and  complete  copies  of all  documents  or
instruments establishing or constituting each such Employee Benefit Plan and all
summary  plan  descriptions  or other  descriptive  materials  relating  thereto
distributed  by the Company and its  Subsidiaries  to  Employees.  Except as set
forth  on  Schedule  2.13(b),  all  Employee  Benefit  Plans  are  currently  in
compliance with all applicable funding  requirements under law. Schedule 2.13(b)
also  sets  forth a list of those  Former  Employees  (or  their  dependents  or
beneficiaries)  who are receiving  continuation  coverage under the Company's or
any of its  Subsidiaries'  medical plans  pursuant to the  Consolidated  Omnibus
Budget  Reconciliation  Act of 1985  ("COBRA")  and the dates upon  which  those
individuals commenced receiving such continuation coverage.  Except as set forth
on Schedule 2.13(b), none of the Company, its Subsidiaries or the Purchaser will
incur any  liability  under  any  Employee  Benefit  Plan or  agreement  with an
Employee solely as a result of the transactions contemplated by this Agreement.

     (c) Except as set forth on  Schedule  2.13 (c)  hereto,  (i) each  Employee
Benefit Plan which is an "employee  pension benefit plan", as defined in Section
3(2) of ERISA,  meets the  requirements  of  Section  401(a) of the Code and any
related trust is exempt from U.S. federal income tax under Section 501(a) of the
Code and (ii) the Company and its Subsidiaries are in compliance in all material
respects with the terms of such Employee Benefit Plans and with the requirements
of the Internal  Revenue Code of 1986,  as amended  (the  "Code"),  and ERISA in
respect  thereto.  None of the Company or its  Subsidiaries  has any  obligation
under any Employee Benefit Plan or otherwise to provide  post-retirement  health
benefits  (exclusive  of  obligations  under  COBRA) with  respect to any of the
Employees or Former Employees.

     (d) The Employees are not and have not in the past three years been covered
by any labor or  collective  bargaining  agreement.  No strike,  work  stoppage,
picketing,  slowdown,  lockout or material labor dispute involving the Company's
or its Subsidiaries'  operations has occurred during the past three years or, to
the Company's knowledge,  is threatened.  To the Company's knowledge, no attempt
at the  organization  of a union involving the Company or its  Subsidiaries  has
occurred during the past three years or is threatened.

     (e) None of the  Company or its  Subsidiaries  has  incurred  any  material
liability  under,  and has complied in all material  respects  with,  the Worker
Adjustment Retraining and

                                        A-7

<PAGE>

Notification  Act and the  regulations  promulgated  thereunder  and any similar
state  laws and does not  reasonably  expect  to incur any such  liability  as a
result of actions taken or not taken prior to the date hereof.

     (f) Except as set forth on Schedule  2.13(f)  hereto or as disclosed in the
SEC  Reports,  the Company and its  Subsidiaries  have  complied in all material
respects with all  applicable  laws,  rules,  regulations  and executive  orders
governing the terms and conditions of employment,  discriminatory practices with
respect to  employment,  hiring and  discharge,  the  employment of aliens,  the
payment of minimum wages and overtime,  workplace health and safety or otherwise
relating to the conduct of employers  with respect to  employees  and  potential
employees,  and except as set forth on Schedule 2.13,  there have been no claims
made or, to the  Company's  knowledge,  threatened  against  the  Company or its
Subsidiaries  arising out of, relating to or alleging any material  violation of
the foregoing.

     2.14 Permits. The Company and its Subsidiaries have all licenses,  permits,
orders, certificates, authorizations, consents and approvals of all governmental
and regulatory authorities and bodies, whether federal, state or local, domestic
or foreign,  which are  necessary for the operation of its business as currently
conducted  ("Permits"),  except for the failure to have such  Permits that could
not,  individually  or in the  aggregate,  reasonably be expected to result in a
Material Adverse Effect.  Except as could not, individually or in the aggregate,
reasonably be expected to result in a Material  Adverse Effect,  the Permits are
in full force and effect and no  suspension  or  cancellation  of any of them is
pending or, to the Company's knowledge, threatened.

     2.15  Intellectual  Property.  Schedule  2.15  hereto sets forth all of the
patents,  registered copyrights and registered trademarks of the Company and its
Subsidiaries, all of which are owned by the Company or its Subsidiaries free and
clear of any Liens.  None of the Company or its  Subsidiaries has infringed upon
or unlawfully  used, in any material  respect,  any patent,  trademark,  service
mark, tradename,  copyright, or trade secret ("Intellectual  Property") owned by
another person. None of the Company or its Subsidiaries has received any written
notice of any claim of  infringement  or other material claim relating to any of
its Intellectual  Property. No shareholder of the Company or its Subsidiaries or
member of any such shareholder's family or any entity controlled by them, or any
Employee or Former  Employee  owns or has any  proprietary,  financial  or other
material interest,  directly or indirectly,  in any Intellectual  Property which
the  Company or its  Subsidiaries  owns,  possesses  or  materially  uses in its
operations.  Schedule  2.15 sets  forth all  confidentiality  or  non-disclosure
agreements  to  which  either  the  Company  or its  Subsidiaries  or any of its
Employees or Former  Employees  is a party and which relate to the  Company's or
its Subsidiaries' business and were executed in the past seven years.

     2.16 No Pending Litigation or Proceedings.  Except as set forth on Schedule
2.16 hereto or as disclosed in the SEC Reports,  there are no material  actions,
suits,  proceedings  (including arbitral proceedings) or investigations  pending
or,  to  the  Company's  knowledge,   threatened  against  the  Company  or  its
Subsidiaries  or  directly  relating  to or  otherwise  directly  affecting  the
business,  assets or properties of the Company and its  Subsidiaries.  Except as
set forth on Schedule 2.16 or as

                                        A-8

<PAGE>

disclosed  in  the  SEC  Reports,  there  is  no  outstanding  judgment,   writ,
injunction,  decree,  award  or  order  of  any  court  or any  governmental  or
regulatory authority or body against or directly affecting the business,  assets
or properties of the Company and its Subsidiaries.

     2.17  Insurance  Coverage.  Each of the  Company and its  Subsidiaries  has
during the past three years maintained  liability,  casualty,  property loss and
other  insurance  policies  with  respect to the conduct of its business in such
amounts,  of such kinds and with such  insurance  carriers as the Company and it
Subsidiaries, as applicable, has deemed appropriate and sufficient for companies
of a similar  size  engaged  in  similar  types of  businesses  and  operations.
Schedule  2.17 hereto sets forth a summary  description  of each such  insurance
policy, listing for each policy the risks insured against,  coverage limits, any
deductible  amounts,  any pending  claims  thereunder  and the term of each such
policy.  Each such policy is in full force and effect,  and no written notice of
cancellation  has been  received  with respect to any such policy,  nor will the
consummation  of the  transactions  contemplated  by this  Agreement  cause  the
cancellation  of, or the right to cancel,  any such policy pursuant to the terms
of such  policy.  The  Company  and its  Subsidiaries  have filed all notices or
reports  required under such policies,  except such filings the failure of which
to make could not reasonably be expected to result in a Material Adverse Effect.

     2.18 Compliance  with Laws.  Except as set forth on Schedule 2.18 hereto or
as disclosed in the SEC Reports,  each of the  Company's  and its  Subsidiaries'
business and  operations are being  conducted in compliance  with all applicable
laws, statutes,  rules, regulations,  ordinances,  codes, orders, franchises and
Permits  of all  governmental  entities,  including  without  limitation,  those
relating  to  occupational  safety and health  and equal  employment  practices,
except for such instances of  noncompliance  that could not,  individually or in
the aggregate, reasonably be expected to result in a Material Adverse Effect. No
notice,  citation,  summons or order has been assessed and no  investigation  or
review is pending or, to the Company's knowledge, threatened by any governmental
or other  entity with  respect to any alleged  material  violation by any of the
Company and its Subsidiaries of any of the foregoing.

     2.19 Environmental Matters.  Except as set forth on Schedule 2.19 hereto or
as  disclosed  in the SEC  Reports,  and except for such matters that could not,
individually or in the aggregate, reasonably be expected to result in a Material
Adverse Effect, (a) there are no investigations,  inquiries or other proceedings
pending or, to the Company's knowledge, threatened with regard to the current or
prior   conduct  of  the  business  and   operations  of  the  Company  and  its
Subsidiaries, or relating to (x) any properties owned or previously owned by the
Company and its Subsidiaries, (y) any properties at which any of the Company and
its Subsidiaries  has conducted  operations or (z) any sites at which any of the
Company and its  Subsidiaries  has disposed of, or arranged for the disposal of,
waste materials, and arising out of or relating to any actual or alleged failure
to comply with any requirement of any law, statute,  rule,  regulation,  code or
ordinance relating to air or water quality, waste management, hazardous or toxic
substances,  or the  protection  of  health or the  environment  ("Environmental
Laws");  (b) the  Company  and  its  Subsidiaries  are in  compliance  with  the
requirements  of  all  Environmental  Laws  in  connection  with  its  business,
operations and otherwise; and (c) none of the properties or sites referred to in
clauses (x), (y) or (z) above is contaminated with

                                        A-9

<PAGE>

any  hazardous  waste or  substance  as a result of any act or  omission  of the
Company and any of its Subsidiaries,  or, to the Company's knowledge, any agent,
servant or bailee of the Company and any of its  Subsidiaries,  to a degree that
poses a risk to health or the  environment  or could  impose a liability  on the
Company.  With regard to compliance with Environmental Laws, the representations
and warranties set forth in this Section 2.19 shall  supersede the provisions of
Section 2.18 hereof.

     2.20 Tax Returns and Taxes.

     (a) The  Company  and its  Subsidiaries  have  filed  all Tax  Returns  (as
hereinafter  defined)  required to be filed by it.  Except  with  respect to any
contested liability for Taxes (as hereinafter defined), as set forth on Schedule
2.20  hereto,  all such Tax Returns  were  correct and  complete in all material
respects.  All Taxes owed by the Company and any of its Subsidiaries (whether or
not shown on any Tax Return) have been paid except for (i) Taxes accrued but not
yet  payable,  (ii) Taxes which are being  contested  in good  faith,  and (iii)
Taxes,  the non-payment of which could not reasonably be expected to result in a
Material  Adverse  Effect.  Except as set forth on  Schedule  2.20,  none of the
Company and its Subsidiaries has received any notice of assessment of additional
Taxes that is currently  pending.  Except as set forth on Schedule 2.20, none of
the  Company  and its  Subsidiaries  has waived any  statute of  limitations  in
respect of Taxes or executed or filed with any Tax  authority  any  agreement or
document  extending the period of  assessment of any Taxes,  and the Company and
its  Subsidiaries  are not  currently the  beneficiary  of any extension of time
within which to file any Tax Return. Except as set forth on Schedule 2.20, there
are no claims, examinations, audits, proceedings or proposed deficiencies for or
in respect of Taxes pending or, to the Company's  knowledge,  threatened against
the  Company  or its  Subsidiaries.  No claim  has been made in  writing  to the
Company  or its  Subsidiaries  in the  past  three  years by an  authority  in a
jurisdiction where the Company and its Subsidiaries do not file Tax Returns that
it is or may be subject to taxation by that jurisdiction.  There are no recorded
Tax Liens on any of the  assets of the  Company  and its  Subsidiaries,  nor are
there  any  security  interests  on any of the  assets  of the  Company  and its
Subsidiaries  that arose in connection with any failure (or alleged  failure) of
the  Company or any of its  Subsidiaries  to pay any Tax  (other  than Liens and
security  interests  for Taxes  not yet due and  payable  or for Taxes  that the
Company  (or any of its  Subsidiaries,  as  applicable)  is  contesting  in good
faith).

     (b) The Company (and each of its Subsidiaries,  as applicable) has withheld
and paid all Taxes  required by applicable law to have been withheld and paid in
connection  with  amounts  paid or owing to any  Employee  or  Former  Employee,
independent contractor, creditor, stockholder or other third party, except where
the  failure to do so could not  reasonably  be expected to result in a Material
Adverse Effect.

     (c)  Except as set forth on  Schedule  2.20,  there is no  dispute or claim
concerning  any Tax  liability  of the Company (or any of its  Subsidiaries,  as
applicable)  either  (i)  claimed  or raised by any  governmental  authority  in
writing or (ii) as to which the  Company or any of its  executive  officers  (or
employees  principally  responsible  for Tax matters) has  knowledge  based upon
personal  contact with any agent of such  authority.  Schedule  2.20 lists those
federal, state, local, and foreign

                                       A-10

<PAGE>

income  Tax  Returns   filed  with  respect  to  the  Company  (or  any  of  its
Subsidiaries, as applicable) that have been audited in the past three years, and
indicates those Tax Returns that currently are the subject of audit.

     (d) The Company (or any of its Subsidiaries, as applicable) has not filed a
consent under Section 341(f) of the Code  concerning  collapsible  corporations.
Except as set forth on  Schedule  2.20(f)  hereto,  the  Company  (or any of its
Subsidiaries,  as applicable) has not made any payments,  nor is it obligated to
make  any  payments,  nor is it a party  to any  agreement  that  under  certain
circumstances could obligate it to make any payments that will not be deductible
under Section 280G of the Code.  The Company has disclosed on its federal income
Tax Returns all  positions  taken  therein that could give rise to a substantial
understatement  of federal  income Tax within the meaning of Section 6662 of the
Code. The Company (or any of its Subsidiaries,  as applicable) is not a party to
any Tax allocation or sharing agreement. The Company has not been a member of an
Affiliated  Group filing a consolidated  federal income tax return (other than a
group the common parent of which is the Company).

     (e) The Company (or any of its  Subsidiaries,  as applicable) does not have
(i)  income   reportable  for  a  period  ending  after  the  Closing  Date  but
attributable  to a transaction  (e.g.,  an installment  sale)  occurring in or a
change in accounting  method made for a period ending on or prior to the Closing
Date which resulted in a deferred  reporting of income from such  transaction or
from such  change in  accounting  method  (other  than a  deferred  intercompany
transaction);  or  (ii)  deferred  gain  or  loss  arising  out of any  deferred
intercompany  transaction.  No "ownership change" (within the meaning of Section
382(g) of the Code) has, to the Company's knowledge,  occurred prior to the date
hereof which currently limits the Company's ability to utilize any net operating
loss carryovers under Section 382 of the Code.

     For purposes of this Agreement,  "Tax" or "Taxes" means any federal, state,
local, or foreign income, gross receipts, license, payroll, employment,  excise,
severance,   stamp,  occupation,   premium,   windfall  profits,   environmental
(including  taxes  under Code  Section  59A),  customs  duties,  capital  stock,
franchise,  profits,  withholding,  social security (or similar),  unemployment,
disability,   real  property,   personal   property,   sales,   use,   transfer,
registration,  value added,  alternative or add-on minimum,  estimated, or other
tax of any kind  whatsoever,  including  any  interest,  penalty,  deficiency or
addition  thereto,  whether  disputed or not, and "Tax Return" means any return,
declaration,  report,  claim for  refund,  or  information  return or  statement
relating to Taxes,  including any schedule or attachment thereto,  and including
any amendment thereof.

     2.21 Outstanding  Registration Rights. Except as set forth on Schedule 2.21
hereto or as disclosed in the SEC Reports, the Company has not in the past three
years  granted (or  incurred any  obligations  or  commitments  to grant) to any
holder or holders of any capital stock (or rights to acquire any capital  stock)
of the  Company  (i) any  rights to request  or demand  registration  of, or the
filing of an offering  circular with respect to,  outstanding  shares of capital
stock of the  Company  under any  securities  laws or rules,  (ii) any rights to
include  any  outstanding  shares  of  capital  stock  of  the  Company  in  any
registration or filing  effected by the Company  pursuant to any securities laws
or

                                       A-11

<PAGE>

rules,  or (iii) any rights to require  the  Company  to take  action  under any
securities laws or rules in order to permit or otherwise facilitate  disposition
of any outstanding shares of the Company's capital stock.

     2.22 Certain Beneficial Owners.

     (a)  Schedule  2.22(a)  hereto  sets  forth  an  analysis  prepared  by the
Company's  auditors  stating the stock ownership of 5-percent  shareholders  (as
such term is defined in Section  382 of the Code) in the Company as of the dates
indicated  therein.  To the Company's  knowledge,  such Schedule  correctly sets
forth in all material  respects the stock ownership of such shareholders and the
changes in such stock ownership as of each fiscal year-end indicated therein.

     (b) Schedule  2.22(b)  lists all options,  warrants,  or other stock rights
issued by the  Company  and  outstanding  as of the date  hereof to any  person,
whether or not a 5-Percent  Shareholder,  that have not yet been exercised as of
the date  hereof,  together  with  the  exercise  dates,  exercise  prices,  any
consideration paid therefor and expiration dates.

     2.23 FDA  Compliance.  The  products  manufactured,  sold,  distributed  or
supplied by each of the Company and its  Subsidiaries,  as  applicable,  are not
adulterated or misbranded  within the meaning of the United States Federal Food,
Drug and Cosmetic Act, as amended ("USFFDCA"),  and comply with any monograph or
other  requirements  of the United States Food and Drug  Administration  ("FDA")
applicable  to the  products  or their  manufacture,  except  for  instances  of
noncompliance  that could not,  individually or in the aggregate,  reasonably be
expected to result in a Material  Adverse  Effect.  Such  products have been and
continue  to  be  manufactured  in  compliance  with  all  applicable  statutes,
ordinances  and  regulations,  including but not limited to, the USFFDCA and the
regulations thereunder, including the current Good Manufacturing Practices which
have been adopted by the FDA, except for instances of  noncompliance  that could
not,  individually  or in the  aggregate,  reasonably be expected to result in a
Material Adverse Effect.  Current Good Manufacturing Practice means current good
manufacturing  practice regulations  established in 21 C.F.R. Parts 210 and 211,
as amended and in effect from time to time,  and other  applicable  FDA policies
relating thereto. Except as set forth on Schedule 2.23 hereto or as disclosed in
the SEC Reports,  none of the Company and its Subsidiaries has in the past three
years  received  any notice or summons  in  respect of a material  violation  or
alleged  material  violation of any statute or regulation  from the FDA or other
similar authorities.

     2.24 Reliance. The representations, warranties, covenants and agreements of
the Company  contained herein and in the certificates and schedules  required to
be delivered in accordance  with the terms of this Agreement  shall,  subject to
Section 11 hereof,  survive any investigation made by the Purchaser and are made
by the Company with the  expectation  that the  Purchaser is relying  thereon in
entering  this  Agreement  and  the  same  shall  not be  deemed  waived  by any
investigation conducted by the Purchaser or its employees, advisors, consultants
or representatives, whether before or after the consummation of the transactions
contemplated hereby.


                                       A-12

<PAGE>

     SECTION 3.  Representations and Warranties of the Purchaser.  The Purchaser
hereby represents and warrants to the Company as follows:

     3.1 Organization. The Purchaser is a corporation duly organized and validly
existing and in good standing  under the laws of Delaware and is a  wholly-owned
subsidiary  of  Merck.  The  Purchaser  has all  necessary  corporate  power and
authority  to own or lease its  properties  and to conduct  its  business as now
being conducted.

     3.2 Authorization. The execution, delivery and performance by the Purchaser
of this Agreement,  the other agreements referred to herein and the transactions
contemplated  hereby and  thereby  have been duly  authorized  by all  requisite
corporate action by the Purchaser and, in the case of the Distribution Agreement
and the Services Agreement to which it is a party, by Merck and Genpharm, as the
case  may be.  This  Agreement  constitutes,  and each of the  other  agreements
referred to herein,  upon execution and delivery,  will constitute,  a valid and
binding  obligation  of the  Purchaser  and,  in the  case  of the  Distribution
Agreement  and the  Services  Agreement  to which it is a  party,  of Merck  and
Genpharm,  enforceable against the Purchaser, Merck or Genpharm, as the case may
be, in accordance with its terms,  except as such  enforceability may be limited
by (i)  bankruptcy  laws and other  similar  laws  affecting  creditors'  rights
generally and (ii) general principles of equity,  regardless of whether asserted
in a proceeding in equity or at law.

     3.3 Non-contravention.  Neither the execution,  delivery and performance of
this Agreement and the other agreements  referred to herein nor the consummation
of the  transactions  contemplated  hereby  or  thereby  will  violate  or be in
conflict with any provision of the articles of organization of the Purchaser or,
in the case of the Distribution Agreement and the Services Agreement to which it
is a party, of Merck or Genpharm,  as the case may be; violate or be in conflict
with any material note, bond, lease,  mortgage,  indenture,  license,  contract,
commitment,  franchise,  permit,  instrument  or  other  material  agreement  or
obligation  to which the  Purchaser,  Merck or  Genpharm  is a party or by which
either of them is  bound;  violate  or be in  conflict  with any law,  judgment,
decree, order, regulation or ordinance by which the Purchaser, Merck or Genpharm
is bound or affected;  or result in the creation or  imposition  of any Liens in
favor of any third party upon any property or assets of the Purchaser,  Merck or
Genpharm.

     3.4 No Brokers or Finders. No person, firm or corporation has or will have,
as a result of any act or  omission by the  Purchaser,  Merck or  Genpharm,  any
right,  interest or valid claim against the Company for any  commission,  fee or
other  compensation  as a finder  or  broker,  or in any  similar  capacity,  in
connection with the transactions contemplated by this Agreement.

     3.5  Governmental   Authorizations;   Third-Party  Consents.  No  approval,
consent,  authorization  or other  action by, or notice to or filing  with,  any
governmental  authority or any other person or entity, and no lapse of a waiting
period,  is necessary or required in connection with the execution,  delivery or
performance by the Purchaser or, in the case of the  Distribution  Agreement and
the Services Agreement to which it is a party, by Merck or Genpharm, as the case
may be, of this

                                       A-13

<PAGE>

Agreement,   the  other  agreements  referred  to  herein  or  the  transactions
contemplated  hereby or  thereby,  except  for such  filings  or  approvals  (a)
required pursuant to the HSR Act and (b) as may be required (by the FDA or other
governmental  authorities)  to be obtained in connection  with the  Distribution
Agreement.

     3.6  Investment  Representations.  (a) The Purchaser and its Affiliates (as
defined in Rule 405 of the Securities  Act of 1933, as amended (the  "Securities
Act")) are  acquiring  the Shares and the  Options  and,  upon  exercise  of the
Options,  will be acquiring  the Option Shares solely for their own accounts and
not with a view to, or for resale in connection with, any  distribution  thereof
within the  meaning of the  Securities  Act.  Each of the  Purchaser,  Merck and
Genpharm is an "accredited  investor" (as defined in Rule 501(a) of Regulation D
promulgated under the Securities Act).

     (b) The Purchaser, on behalf of itself and its Affiliates, understands that
(i) the Shares and the Option have not been  registered,  and the Option Shares,
when issued,  will not be registered  under the Securities Act or any applicable
state  securities  laws,  by  reason  of  their  issuance  by the  Company  in a
transaction exempt from the registration  requirements of the Securities Act and
applicable state securities laws and (ii) the Shares, the Options and the Option
Shares  must be held by the  Purchaser  (or Merck or  Genpharm,  as  applicable)
indefinitely  unless a subsequent  disposition  thereof is registered  under the
Securities  Act and  applicable  state  securities  laws or is exempt  from such
registrations.

     (c) The  Purchaser,  on behalf of itself and its  Affiliates,  acknowledges
that no  representations or warranties have been made or furnished to, or relied
on by,  the  Purchaser  or any of its  representatives  in  connection  with its
purchase of the Shares except as expressly  provided  herein.  The Purchaser has
such  knowledge  and  experience  in financial  and business  matters that it is
capable of evaluating the risks and merits of this investment.

     (d) The  Purchaser,  on behalf of itself and its  Affiliates,  acknowledges
that,  following  its  acquisition  of the  Shares,  the  Purchaser  will  be an
Affiliate  of  the  Company  and  will  be  subject  to  all   requirements  and
restrictions  applicable to Affiliates under the Securities Act and the Exchange
Act (including the rules and regulations promulgated thereunder).

     SECTION 4. Conditions to the Company's Obligation.

     The obligation of the Company to consummate the  transactions  contemplated
hereby shall be subject to the  satisfaction or waiver (other than in respect of
Sections 4.4, 4.6 and 4.8 hereof) by the Company, at or prior to the Closing, of
all the following conditions:

     4.1 Representations  and Warranties.  The representations and warranties of
the  Purchaser  set forth in this  Agreement  shall be true and  correct  in all
material respects on and as of the date hereof and on and as of the Closing Date
(with the same effect as though such  representations  and  warranties  had been
made on and as of such Closing Date),  and officers of the Purchaser  shall have
certified to such effect to the Company in writing.

                                       A-14

<PAGE>

     4.2  Performance  of  Obligations.  The  Purchaser  shall  have  performed,
satisfied and complied with all covenants, agreements and conditions required by
this  Agreement to be  performed,  satisfied or complied with by it on or before
the Closing  Date,  and officers of the Purchaser  shall have  certified to such
effect to the Company in writing.

     4.3  Opinion of Counsel.  The  Company  shall have  received  from  Coudert
Brothers,  counsel for the Purchaser, an opinion addressed to the Company, dated
the Closing Date, in form and substance reasonably  satisfactory to the Company,
it being  understood  that  Coudert  Brothers  may  rely  upon  the  opinion  of
Klaus-Peter  Brandis,  Head of the Legal Department of Merck, for all matters of
German law, if applicable.

     4.4 No  Litigation  or  Legislation.  No federal,  state,  local or foreign
statute,  rule or regulation shall have been enacted after the date hereof,  and
no  litigation,  proceeding,  governmental  inquiry  or  investigation  shall be
pending,  which  prohibits  or seeks to prohibit  or  materially  restricts  the
consummation  of the  transactions  contemplated  by this Agreement or the other
agreements provided for herein.

     4.5 Clal Sale of Shares. Merck (or its designee) shall have purchased those
certain shares of Common Stock beneficially owned by Clal in accordance with the
terms of the Clal Stock Purchase Agreement,  and all agreements between Clal and
the Company  relating to or arising out of Clal's  acquisitions  of Common Stock
shall be  terminated  by the  parties  thereto  and be of no  further  force and
effect.

     4.6 HSR Act. All  applicable  waiting  periods under the HSR Act shall have
expired or been terminated with respect to the transactions contemplated by this
Agreement.

     4.7 Distribution  Agreement in Effect. The Distribution  Agreement shall be
in full force and effect and there shall exist no facts or circumstances  which,
with the giving of notice or the  passage of time or both,  would  constitute  a
material default thereunder by Genpharm.

     4.8  Shareholders'  Approval.  The  Shareholders'  Approval  of each of the
Proposals  shall  have been  obtained  and all of the  Nominees  (as  defined in
Section 7.3 hereof) shall have been elected.

     4.9  Fairness  Opinion.  The  fairness  opinion of Gruntal,  the  Company's
financial  advisor,  rendered  with  regard  to this  Agreement  and  the  other
agreements  to be  entered  into in  connection  herewith  and the  transactions
contemplated hereby and thereby shall have been reconfirmed by Gruntal as of the
date of mailing to the Company's  shareholders of the definitive proxy statement
(the "Proxy  Statement") in respect of the Company's meeting of its shareholders
to be held in connection with the Proposals (the "Meeting").

     4.10 Purchase Price and Other Closing Deliveries.  The Purchaser shall have
paid the Purchase Price and delivered, or cause to be delivered, the agreements,
instruments and certificates specified in Section 1.3(b) hereof.

                                       A-15

<PAGE>

     4.11  Consents and Waivers.  The Company  shall have  obtained all material
consents  and waivers  necessary  or  appropriate  for its  consummation  of the
transactions  contemplated by this Agreement, as specified in Section 2.8 hereof
and Schedule 2.8 hereto, and the other agreements referred to herein after using
its reasonable best efforts to obtain them.

     4.12 Services  Agreements.  Merck and Genpharm shall have duly executed and
delivered to the Company the Services Agreements.

     4.13 Purchaser Board  Approval.  The Board of Directors of Merck shall have
approved this Agreement and the transactions  contemplated hereby prior to April
3, 1998.

     SECTION 5. Conditions to the Purchaser's Obligation.

     The obligation of the Purchaser to consummate the transactions contemplated
hereby shall be subject to the  satisfaction or waiver (other than in respect of
Sections 5.4, 5.5 and 5.9 hereof) by the Purchaser,  at or prior to the Closing,
of all the following conditions:

     5.1 Representations  and Warranties.  The representations and warranties of
the  Company  set  forth in this  Agreement  shall be true  and  correct  in all
material respects on and as of the date hereof and on and as of the Closing Date
(with the same effect as though such  representations  and  warranties  had been
made on and as of such Closing  Date),  and  officers of the Company  shall have
certified to such effect to the Purchaser in writing.

     5.2 Performance of Obligations. The Company shall have performed, satisfied
and complied with all  covenants,  agreements  and  conditions  required by this
Agreement to be  performed,  satisfied  or complied  with by it on or before the
Closing Date, and officers of the Company shall have certified to such effect to
the Purchaser in writing.

     5.3 Opinion of Counsel.  The  Purchaser  shall have  received from Hertzog,
Calamari  & Gleason,  counsel  for the  Company,  an  opinion  addressed  to the
Purchaser, dated the Closing Date, in form and substance reasonably satisfactory
to the Purchaser.

     5.4 No  Litigation  or  Legislation.  No federal,  state,  local or foreign
statute,  rule or regulation shall have been enacted after the date hereof,  and
no  litigation,  proceeding,  governmental  inquiry  or  investigation  shall be
pending,  which  prohibits  or seeks to prohibit  or  materially  restricts  the
consummation  of the  transactions  contemplated  by this Agreement or the other
agreements  provided for herein, or materially  restricts or impairs the ability
of the Purchaser to own an equity interest in the Company.

     5.5 HSR Act. All  applicable  waiting  periods under the HSR Act shall have
expired or been terminated with respect to the transactions contemplated by this
Agreement.


                                       A-16

<PAGE>

     5.6 Board Resignations.  The Purchaser shall have received the resignations
of the current  members of the Board of  Directors  of the  Company,  subject to
their re-election in accordance with Section 7.3 hereof.

     5.7 No Material Adverse Effect. Since the date hereof, there shall not have
occurred a condition or event constituting a Material Adverse Effect (other than
in respect of the matter set forth on Schedule 2.10 hereto).

     5.8 ISRA. The Company shall have delivered to the Purchaser evidence of the
Company's having obtained an ISRA Clearance (as defined in Section 7.4 hereof).

     5.9  Shareholders'  Approval.  The  Shareholders'  Approval  of each of the
Proposals  shall  have been  obtained  and all of the  Nominees  shall have been
elected.

     5.10 Closing  Deliveries.  The Company shall have delivered the Shares, the
Options and the agreements,  instruments and  certificates  specified in Section
1.3(a) hereof.

     5.11  Distribution  Agreement.  There shall exist no facts or circumstances
which,  with  the  giving  of  notice  or the  passage  of time or  both,  would
constitute a material default by the Company under the Distribution Agreement.

     5.12 Services Agreements; Options. The Company shall have duly executed and
delivered to Merck and Genpharm the Services Agreements and the Options.

     5.13 Board  Approval.  The Board of Directors of Merck shall have  approved
this Agreement and the transactions contemplated hereby prior to April 3, 1998.

     5.14 Option  Standstill  Agreements.  At least  fifteen  (15) days prior to
Closing,  the Company  shall have duly  executed and  delivered to the Purchaser
agreements in writing,  in form reasonably  satisfactory to the Purchaser,  from
(i) the four persons listed on Schedule 5.14(a) hereto that, notwithstanding the
terms of any stock option plan or any option heretofore granted, not to exercise
or seek to  exercise  such  options  until  three  (3)  years  and ten (10) U.S.
business days from the Closing Date and (ii) substantially all other persons who
then hold unexercised options, warrants or other stock rights to purchase Common
Stock,  other than those  persons set forth on  Schedule  5.14(b)  hereto,  not,
notwithstanding  the terms of any stock  option  plan or any option  theretofore
granted,  to exercise or seek to exercise such options,  warrants or other stock
rights, except to the extent indicated on Schedule 5.14(b).

     5.15 Section 7.10 Agreement. The Company shall have delivered the agreement
of the Chairman of the Company referred to in Section 7.10 hereof.


                                       A-17

<PAGE>

     5.16 Clal Share Purchase.  The Purchaser shall have purchased,  after using
its  reasonable  best  efforts to do so,  those  certain  shares of Common Stock
beneficially  owned  by Clal in  accordance  with the  terms  of the Clal  Stock
Purchase Agreement.

     5.17  Consent.  The Company  shall have obtained the approvals set forth on
Schedule 2.3, Item 1, hereto.


     SECTION 6. Covenants of the Parties.

     The Company and the Purchaser hereby covenant as follows:

     6.1  Hart-Scott-Rodino  Notification.  As soon  as  practicable  after  the
execution of this  Agreement,  the Company and the Purchaser shall each file, or
cause to be filed, with the Federal Trade Commission and the Antitrust  Division
of the  United  States  Department  of  Justice,  pursuant  to the HSR Act,  the
notifications  and  documentary   materials  required  in  connection  with  the
transactions  contemplated  by this Agreement.  Thereafter,  the Company and the
Purchaser will file any additional  information requested as soon as practicable
after  any  receipt  of a  request  for  additional  information  and  shall use
reasonable  best efforts to obtain early  termination of the applicable  waiting
period under the HSR Act. The Company and the  Purchaser  shall  coordinate  and
cooperate  with each other in exchanging  such  information  and providing  such
reasonable  assistance as may be requested in connection with such filings.  All
filing fees in connection with the HSR Act shall be paid by the Purchaser.

     6.2 Publicity. The Company and the Purchaser shall consult with each other,
to the extent reasonably practicable,  as to the form and substance of any press
releases and other  third-party  communications  or disclosures  relating to the
negotiation,  execution,  delivery and consummation of this Agreement, the other
agreements  referred  to herein,  and the  transactions  contemplated  hereby or
thereby.  No party shall be prohibited  from issuing or filing any press release
or other third-party communication or disclosure which, upon advice of its legal
counsel,  shall be deemed  necessary or appropriate  under applicable law or the
applicable rules of any stock exchange; provided, however, that such party shall
have first  consulted  with the other  party as to the form and  content of such
disclosure.  This covenant shall survive the Closing or any  termination of this
Agreement.

     6.3 Confidentiality.  All information to which access is given or furnished
by one  party  to the  other in  connection  with  the  negotiation,  execution,
delivery and consummation of this Agreement,  the other  agreements  referred to
herein,  and the  transactions  contemplated  hereby  or  thereby  shall be kept
confidential  by each  party  and  shall be used  only in  connection  with this
Agreement,  such other agreements and the transactions  contemplated  hereby and
thereby;  provided,   however,  that  the  foregoing  shall  not  apply  to  any
information  that (a) shall be publicly  available  as of the date  hereof,  (b)
shall become publicly available other than as a result of prohibited  disclosure
by such party, (c) shall be disclosed to such party by any person or entity that
is not known to such  party to be subject  to any  confidentiality  restrictions
imposed by the other party or (d) shall be

                                      A-18

<PAGE>

required to be disclosed by law, the  applicable  rules of any stock exchange or
by order of any court of competent jurisdiction. Without limiting the foregoing,
the Purchaser  shall not disclose,  and shall use its reasonable best efforts to
cause its Affiliates not to disclose,  any such confidential  information to any
person or entity  that is not an  Affiliate  or a  director  or  officer of such
Affiliate or any advisor thereto. This covenant shall survive the Closing or any
termination of this Agreement.

     6.4  Further  Assurances.  Upon  reasonable  request of a party and without
further  consideration,  the other party, whether prior to or after the Closing,
shall execute, acknowledge and deliver all such other instruments and documents,
and  shall  take all  such  other  actions  for the  purpose  of  effecting  and
evidencing the consummation of the  transactions  contemplated by this Agreement
and the other agreements referred to herein.  Without limiting the generality of
the foregoing,  the Company shall, and shall cause its Subsidiaries to, from the
date hereof  until the earlier of the Closing  Date or the  termination  of this
Agreement  pursuant  to  Section  13.11  hereof,  provide  all  information  and
documents  reasonably  requested by the Purchaser relating to a determination of
the Company's  status as a United States real property holding  corporation,  as
defined under the Code.

     SECTION 7. Covenants of the Company.

     The Company (and the Purchaser,  to the extent  expressly  provided in this
Section 7) hereby covenants as follows:

     7.1  Exchange  Act  Filings.  From and after the date hereof to the Closing
Date or the earlier  termination  of this  Agreement  pursuant to Section  13.11
hereof,  the Company  shall use its best efforts to file in a timely  manner all
reports  required  to be filed by it with the SEC  under  the  Exchange  Act and
shall, promptly upon filing, deliver copies of such reports to the Purchaser.

     7.2 Proxy Statement;  Meeting; Listing Applications.  (a) The Company shall
prepare,  review with the Purchaser  and its counsel,  and file with the SEC the
Proxy Statement as soon as reasonably  practicable  after the date hereof.  Each
party shall furnish all information  concerning itself and related persons which
is required or  customary  for  inclusion  in the Proxy  Statement.  The Company
shall,  as soon as reasonably  practicable  after the date hereof,  (i) take all
steps  necessary to duly call, give notice of, convene and hold a meeting of its
shareholders  for the  purpose of  securing  the  Shareholders'  Approval to the
Proposals  (such meeting is presently  contemplated by the parties to be held in
June  1998);  (ii)  distribute  to  its  shareholders  the  Proxy  Statement  in
accordance  with  applicable  Federal and state laws and with its Certificate of
Incorporation  and By-Laws;  and (iii) recommend (in the Proxy Statement and, if
deemed  appropriate by the Company,  otherwise) to its shareholders  approval of
the Proposals. Notwithstanding anything to the contrary contained herein, if the
Agreement shall be terminated (or is subject to termination) pursuant to Section
13.11 hereof, the Company may postpone,  adjourn or cancel the Meeting, withdraw
or change  its  recommendation  to its  shareholders  and/or  withdraw  or delay
distribution of the Proxy Statement.

     (b) The Company  shall use its  commercial  best efforts to have the Shares
and the Option  Shares  listed on The New York Stock  Exchange  and The  Pacific
Stock Exchange.

                                       A-19

<PAGE>

     7.3 Board  Representation.  (a) Subject to the conditions set forth herein,
the Company shall  nominate,  and the Company and the Purchaser  shall use their
best  efforts to cause the  election at the Meeting  of,  certain  persons to be
designated  by  each  of  the  Purchaser  and  the  Company  (collectively,  the
"Nominees"), as provided herein, to serve as directors on the Board of Directors
of the Company such that:

          (i) a majority of the members of such Board shall be  comprised of the
     Purchaser's designated representatives; and

          (ii)  three of the  members of such Board  shall be  comprised  of the
     Company's  designated  representatives  consisting  of  Kenneth  I.  Sawyer
     ("Sawyer")  and two  additional  representatives  designated by the current
     Board of Directors of the Company (collectively, the "Company Designees").

Notwithstanding  anything to the contrary contained herein,  each representative
designated by the Purchaser in  accordance  with Section  7.3(f) hereof shall be
nominated  for  election  to  serve  on  the  Board  of  Directors  unless  such
representative  shall not be  satisfactory  to the  Company's  current  Board of
Directors for good faith reasons and each Company Designee shall be nominated to
serve on the Board of Directors  unless such Designee  (other than Sawyer) shall
not be satisfactory to the Purchaser for good faith reasons. All current members
of the  Company's  Board of  Directors  not  nominated  as set forth above shall
resign  effective upon the Closing.  Any current members of such Board nominated
as set forth above shall resign  effective  upon the  Closing,  subject to their
renomination and re-election as set forth herein. All Nominees shall take office
if, and only if, the Closing shall occur.

     (b) Any director  designated  hereunder shall serve subject to the terms of
the Company's Certificate of Incorporation and By-laws, each as in effect on the
Closing Date, and the provisions of applicable law.

     (c) The Company  Designees and the Purchaser shall jointly designate two of
the Company's directors to comprise the audit committee of the Company.  Each of
such directors must qualify as independent, outside directors in accordance with
the rules and regulations of The New York Stock Exchange.

     (d) The directors  designated  by the Purchaser  shall serve as Class I and
Class III directors of the Company (as allocated by the  Purchaser)  whose terms
shall  expire in the years 2000 and 1999,  respectively.  The Company  Designees
shall serve as Class II directors of the Company whose terms shall expire in the
year 2001. There shall be no Class II directors other than the Company Designees
(and their respective successors selected in accordance with Section 8.1 hereof)
through May 31, 2001.

     (e) The Company shall include in the Proxy Statement distributed in respect
of the Meeting the Proposals  and shall  recommend its approval of each Proposal
(including approval of all

                                       A-20

<PAGE>

Nominees) by the shareholders of the Company.  Sawyer and the Purchaser (and its
Affiliates) agree to vote any shares of Common Stock which they own or otherwise
have the power to vote in favor of each of the Proposals  (including approval of
all Nominees).

     (f) The Company  shall give the Purchaser  written  notice not less than 10
days prior to the filing  with the SEC of the  preliminary  Proxy  Statement  in
respect of the Meeting to allow the  Purchaser  to  designate  its  nominees for
director  for  inclusion  in such Proxy  Statement.  The  Company  shall have no
obligation  to include such nominees in the Proxy  Statement  unless the Company
receives written notice from the Purchaser setting forth its designated nominees
(along with all  biographical and other  information  necessary for inclusion in
the Proxy  Statement) not later than five days after the Company's notice to the
Purchaser.

     7.4 Environmental Matters. For each parcel of real property which is owned,
operated, leased or used by the Company and any of its Subsidiaries in the State
of New Jersey,  the Company shall,  and shall cause each of its Subsidiaries to,
as applicable,  comply with the obligations imposed by the New Jersey Industrial
Site Recovery Act and any regulations promulgated thereunder, at or prior to the
Closing,  by  either  (a)  securing  any  of  the  following:  (i) a  letter  of
nonapplicability  from the New Jersey  Department  of  Environmental  Protection
("NJDEP");  (ii)  approval by NJDEP of a negative  declaration  submitted by the
Company;  (iii)  a no  further  action  letter  from  NJDEP;  (iv) a  letter  of
authorization  for the  transfer of  ownership  from NJDEP  without any material
conditions  thereto;  or (v)  approval  from  NJDEP of a  remediation  agreement
reasonably  acceptable  to the  Purchaser;  or (b) filing a De Minimis  Quantity
Exemption  Affidavit  with NJDEP (any of the items listed in clauses (a) and (b)
above being an "ISRA Clearance").

     7.5 Conduct of Business Prior to Closing. From and after the date hereof to
the  Closing  Date or the  earlier  termination  of this  Agreement  pursuant to
Section  13.11 hereof,  except as set forth on Schedule 7.5 hereto,  neither the
Company nor its Subsidiaries shall (a) conduct their respective businesses other
than in the ordinary course, except as contemplated by this Agreement; (b) amend
its charter or by-laws;  (c) sell,  lease or  otherwise  dispose of any material
assets  or  properties  owned  or  used in the  operation  of  their  respective
businesses,  except  for the  sale of  inventory  and  disposition  of  obsolete
equipment  in the  ordinary  course  of  business;  (d)  dissolve,  or  agree to
dissolve,  or merge or consolidate  with, or agree to merge or consolidate with,
or purchase or agree to purchase all or  substantially  all of the assets of, or
otherwise acquire, any other business entity; (e) authorize for issuance,  issue
or sell  any  additional  shares  of its  capital  stock  or any  securities  or
obligations  convertible  into shares of its capital stock or issue or grant any
option,  warrant or other  right to purchase  any shares of its  capital  stock,
except for (i) the granting of options,  warrants or rights under the  Company's
existing  stock or other plans (as such are set forth on Schedule  2.13  hereto)
and (ii) the issuance or sale of capital  stock  pursuant to the exercise of any
options,  warrants,  or rights  granted  prior to the date  hereof to any of the
Company's  employees,  directors,  independent  contractors  or other agents and
listed on Schedule  2.12  hereto;  (f) redeem,  buy back,  or cancel any shares,
securities, options, warrants or other stock rights in the Company; or (g) other
than in the  ordinary  course of business,  enter into any material  contract or
agreement,  or  incur  any  material  capital  expenditure,  which  has not been
approved by the Purchaser.

                                      A-21

<PAGE>

     7.6 Options, Warrants or Other Stock Rights. From and after the date hereof
to the Closing Date or the earlier  termination  of this  Agreement  pursuant to
Section  13.11 hereof,  the Company  shall issue options and warrants,  or other
stock rights under the Company's  existing  stock option or stock purchase plans
only if the  exercise  date is no earlier than three years from the Closing Date
and the options,  warrants or other stock rights are issued in  connection  with
the  performance  of  services  for the  Company  and  qualify as  "compensatory
options" within the meaning of Treas. Reg. Sec. 1.382-4(d)(8)(iii).

     7.7 Other Agreements. At the Closing, upon satisfaction or permitted waiver
of the conditions  set forth in Section 4 hereof,  the Company shall execute and
deliver the agreements, instruments and certificates specified in Section 1.3(a)
hereof.

     7.8  Right of First  Refusal.  (a)  Subject  to the  conditions  and  other
provisions set forth in this Section 7.8 and in Section 8.4 hereof, the Company,
for a period  of six years  following  the  Closing,  shall  give the  Purchaser
written  notice (the  "Transaction  Notice") of the Company's  intention to sell
equity  securities  of the Company in any offering  not subject to  registration
under the  Securities Act (or, if subject to  registration  under the Securities
Act, in any offering for cash only)  specifying the terms and conditions of such
offering,  including the type and amount of  consideration to be received by the
Company.  Subject  to the  conditions  and  other  provisions  set forth in this
Section  7.8 and in Section  8.4  hereof,  the  Purchaser  shall have the right,
exercisable by giving written notice to the Company within 30 days after receipt
of the Transaction Notice, to purchase all, but not less than all, of the equity
securities  described in the Transaction  Notice on substantially the same terms
and conditions as specified in such  Transaction  Notice.  In the event that the
Purchaser   shall  not  provide  notice  of  its  election  to  consummate  such
transaction  within  such  30-day  period,  the  Company  may  sell  the  equity
securities  to any third  party or  parties  (a  "Third-Party  Transaction")  on
substantially  the same terms and  conditions  as specified  in the  Transaction
Notice at any time within 90 days after the expiration of such 30-day period. If
the Company shall not  consummate a Third-Party  Transaction  within such 90-day
period,   the  consummation  of  such  Transaction  or  any  other   Third-Party
Transaction shall again be subject to the Purchaser's  rights under this Section
7.8(a).

     (b) The closing of any  transaction  to be  consummated  with the Purchaser
pursuant  to this  Section 7.8 shall take place at the offices of the Company or
its counsel on a date designated by the Company and reasonably acceptable to the
Purchaser  not  later  than  60  days  after  the  Purchaser's  receipt  of  the
Transaction Notice.

     7.9 Appointment of COO. As soon as practicable  following the Closing,  the
Board of Directors of the Company  shall duly elect a designee of the  Purchaser
as the  President and Chief  Operating  Officer (COO) of the Company and each of
its Subsidiaries.

     7.10 Agreement of the Chairman of the Company. At the Closing,  the Company
shall  deliver  a  fully   executed   agreement  to  the  Purchaser   reasonably
satisfactory  to the Purchaser  whereby the Chairman of the Company,  Kenneth I.
Sawyer,  shall expressly (i) agree to the appointment referred to in Section 7.9
above; (ii) agree that he shall serve as the Chairman and Chief Executive

                                       A-22

<PAGE>

Officer of the Company and each of its Subsidiaries;  and (iii) acknowledge that
Section 7.9 hereof and this Section 7.10 hereof do not  constitute a breach or a
violation  by the  Employer  (as  such  term  is  used  in the  below  mentioned
Employment  Agreement) of the terms of his employment pursuant to the Employment
Agreement  between  the  Company  and  Sawyer,  dated as of October 4, 1992,  as
amended.

     7.11 Rights Agreement.  Each of the Company and First City Transfer Company
(as successor rights agent) shall, prior to the Closing,  execute and deliver an
amendment to the Rights Agreement, dated August 6, 1991, as amended (the "Rights
Agreement"),   exempting   from  operation   under  the  Rights   Agreement  the
acquisitions  of shares of  Common  Stock  pursuant  to this  Agreement  and the
Options. Such amendment shall be in full force and effect and constitute a valid
and  binding  agreement  of the  Company  enforceable  against  the  Company  in
accordance with its terms.

     7.12 U.S. Real Property Holding Corporation. From and after the date hereof
to the Closing Date or the earlier  termination  of this  Agreement  pursuant to
Section 13.11  hereof,  the Company  shall (a) use  reasonable  efforts to avoid
making  any  changes in the  composition  of its assets  which  would  cause the
Company to be classified as a United  States real property  holding  corporation
within the meaning of Section  897(c)(2)  of the Code and (b) obtain the consent
of the  Purchaser  prior to the  acquisition  of any United States Real Property
Interest (as defined in Section 897 of the Code).

     SECTION 8. Covenants of the Purchaser.

     The  Purchaser  (and the  Company  following  the  Closing,  to the  extent
expressly provided in this Section 8) hereby covenants as follows:

     8.1 Company  Designees.  For a period of three years following the Closing,
the Purchaser shall not cause, and shall use its best efforts not to permit, (i)
the removal, except for cause (as such term is defined and used under New Jersey
corporate  law),  of any of the Company  Designees  serving as  directors of the
Company prior to the scheduled  expiration of their terms or (ii) the shortening
of any of such  Designees'  terms as  directors.  In the event that any  Company
Designee shall resign or cannot otherwise  continue to serve as a director,  the
remaining Company  Designee(s) shall designate a replacement  therefor and, upon
such designation,  unless such designee shall not be reasonably  satisfactory to
the Purchaser,  the Company and the Purchaser  shall use their  reasonable  best
efforts to cause the appointment and/or election of such designated  replacement
to the Company's Board of Directors.  Such replacement directors shall be deemed
to be Company Designees for the purpose of this Agreement.

     8.2 No Modification. For a period of three years following the Closing, the
Purchaser  shall not cause,  and shall use its  reasonable  best  efforts not to
permit, the Company to agree to any amendment, modification or waiver of or take
any action in respect of this Agreement, the Distribution Agreement or the other
agreements referred to herein, including,  without limitation, in respect of any
agreement  or  settlement  relating  to a dispute  or claim for  indemnification
hereunder

                                       A-23

<PAGE>

or thereunder,  without the prior written  consent of at least a majority of the
Company  Designees  (including any replacements  therefor as provided in Section
8.1 hereof).

     8.3 Other Agreements. At the Closing, upon satisfaction or permitted waiver
of the  conditions  set forth in Section 5 hereof,  the Purchaser  shall pay the
Purchase  Price  and  execute  and  deliver  the  agreements,   instruments  and
certificates specified in Section 1.3(b) hereof.

     8.4 Related Party  Transactions.  For a period of three years following the
Closing, except as expressly permitted by this Agreement or any other agreements
referred to herein,  the Purchaser  shall not cause or permit the Company or its
Subsidiaries existing on the date of the Agreement,  directly or indirectly,  to
engage in or enter into any, or to amend or terminate any then validly existing,
transaction,  arrangement  or agreement  with,  or to make any  distribution  or
dividend of property or monies to, the  Purchaser or any  Affiliate or associate
(as defined in Rule 405 of the  Securities Act  ("Associate")  of the Purchaser,
without  the prior  written  consent  of a  majority  of the  Company  Designees
(including any replacements therefor as provided in Section 8.1 hereof).

     8.5  Business  Combinations.  For a period  of three  years  following  the
Closing,  neither the Purchaser nor any of its  Affiliates or Associates  shall,
without  the prior  written  consent  of a  majority  of the  Company  Designees
(including any replacements  therefor as provided in Section 8.1 hereof) and the
prior receipt from an independent  nationally  recognized  investment  bank of a
written  fairness  opinion to the effect that the proposed  transaction  is fair
(from a financial point of view) to all shareholders of the Company, (i) propose
that the Company, or cause or permit the Company to, merge, consolidate or enter
into any other  business  combination  with or into another  entity  (including,
without limitation,  any "short-form" merger), (ii) propose that the Company, or
cause or permit the Company to, sell, lease,  pledge or otherwise dispose of all
or any material portion of the assets of the Company,  (iii) propose or make, or
cause or permit the  Company to propose or make,  any  exchange  offer or tender
offer for, or repurchase  of, any securities of the Company or (iv) propose that
the  Company,  or cause or  permit  the  Company  to,  recapitalize,  liquidate,
dissolve  or, to the extent it would cause the Company not to be  publicly-held,
reorganize.

     8.6 Executive Committee. For a period of three years following the Closing,
the Purchaser shall cause the Company to, and the Company shall,  constitute and
maintain an executive  committee of the  Company's  Board of Directors to manage
the fundamental  matters  concerning the Company in the intervals  between Board
meetings, and each shall use its reasonable best efforts to cause Sawyer (or his
designee who shall be a member of the  Company's  Board of Directors) to be, and
remain for such period, a duly appointed, full member of such committee.

     SECTION 9. Transfer of Securities.  The  Purchaser,  for itself and each of
its Affiliates, agrees as follows:

     9.1 Transfer  Restrictions.  The  Purchaser  and its  Affiliates  shall not
transfer any of the Shares or the Option Shares unless such transfer shall be in
full  compliance  with all  applicable  provisions of the Securities Act and all
applicable provisions of state securities laws.

                                       A-24

<PAGE>

     9.2 Legends. Each certificate for the Shares and the Option Shares shall be
endorsed with the following legend:

         "THE SECURITIES  REPRESENTED  HEREBY HAVE NOT BEEN REGISTERED UNDER THE
         SECURITIES ACT OF 1933 OR UNDER ANY STATE  SECURITIES LAWS, AND MAY NOT
         BE SOLD,  TRANSFERRED,  PLEDGED OR OTHERWISE DISPOSED OF IN THE ABSENCE
         OF AN EFFECTIVE  REGISTRATION  STATEMENT UNDER  APPLICABLE  FEDERAL AND
         STATE SECURITIES LAWS OR AN OPINION OF COUNSEL REASONABLY  SATISFACTORY
         TO THE COMPANY  THAT THE  TRANSFER IS EXEMPT  FROM  REGISTRATION  UNDER
         APPLICABLE FEDERAL AND STATE SECURITIES LAWS."

     SECTION  10.  Exchanges;  Lost,  Stolen  or  Mutilated  Certificates.  Upon
surrender by the Purchaser (or Merck or Genpharm,  as applicable) to the Company
of any certificates  representing the Shares or the Option Shares,  the Company,
at its expense,  shall issue in exchange therefor,  and deliver to the Purchaser
(or  Merck or  Genpharm,  as  applicable),  a new  certificate  or  certificates
representing  such  Shares or Option  Shares,  in such  denominations  as may be
requested in writing by the  Purchaser  (or Merck or Genpharm,  as  applicable).
Every surrendered certificate representing the Shares or the Option Shares shall
be duly endorsed or be  accompanied by a written  instrument of the  Purchaser's
(or Merck's or Genpharm's,  as applicable)  attorney duly authorized in writing.
Upon  receipt  of  evidence  satisfactory  to the  Company  of the loss,  theft,
destruction or mutilation of any certificate  representing  any Shares or Option
Shares, and in case of any such loss, theft or destruction,  upon delivery of an
indemnity  agreement  satisfactory  to the  Company,  or in  case  of  any  such
mutilation,  upon surrender and  cancellation of such  certificate,  the Company
shall issue and deliver to the Purchaser (or Merck or Genpharm, as applicable) a
new  certificate  for such Shares or Option Shares of like tenor and in the same
amount and name in lieu of such lost, stolen or mutilated certificate.

     SECTION 11. Survival of  Representations,  Warranties and  Agreements.  The
representations  and warranties  (including the Schedules hereto) of the parties
contained herein and the agreements and covenants  contained in Section 7 hereof
(excluding Sections 7.3, 7.8 and 7.9 hereof) shall survive the date hereof for a
period  of 12  months  following  the  Closing  Date  (the  "Survival  Period");
provided, that (i) a party shall not be liable to the other party hereto for any
claim for  indemnification  under  Section 12 hereof in respect of a breach of a
representation  or warranty unless written notice thereof  describing such claim
with reasonable  specificity shall be delivered to the Indemnitor (as defined in
Section 12.1 hereof) prior to the expiration of the Survival Period and (ii) the
representations  and  warranties  relating to Taxes  contained  in Section  2.20
hereof  shall  survive  until  the  expiration  of the  appropriate  statute  of
limitation.

     SECTION 12. Indemnification.

     12.1  Indemnitors;  Indemnified  Persons.  For purposes of this Section 12,
each party  which,  pursuant to this Section 12,  agrees to indemnify  any other
person or entity shall be referred to as the

                                       A-25

<PAGE>

"Indemnitor"  with  respect to such  person or entity,  and each such  person or
entity who is indemnified shall be referred to as the "Indemnified  Person" with
respect to such Indemnitor.

     12.2 Company  Indemnity.  The Company  hereby  agrees to indemnify and hold
harmless each of the Purchaser and it Affiliates,  and its directors,  officers,
employees,  agents and controlling  persons (within the meaning of Section 15 of
the Securities  Act or Section 20(a) of the Exchange Act),  from and against any
and all claims,  liabilities,  losses, damages and expenses (including,  without
limitation,  reasonable  attorneys' fees and disbursements)  asserted against or
incurred by any such Indemnified Person which are caused by or are related to or
arise out of (a) subject to Section 11 hereof,  the Company's material breach of
any of its  representations,  warranties,  covenants or agreements  contained in
this  Agreement,  (b) any untrue  statement  or alleged  untrue  statement  of a
material  fact  contained  in the Proxy  Statement  or the  omission  or alleged
omission to state a material fact required to be stated  therein or necessary to
make the  statements  therein  not  misleading  (a  "Violation")  or (c) (i) any
material violation by the Company or any Subsidiary thereof of any Environmental
Laws,  or the  disposal,  discharge or release of solid  wastes,  pollutants  or
hazardous  substances,  whether in compliance  with  Environmental  Laws or not,
other than in respect of those  matters set forth on  Schedule  12.2 hereto (ii)
the ownership, operation or use of any landfill, wastewater treatment plant, air
pollution  control  equipment,  storage  lagoon  or other  waste  management  or
pollution control  facility,  whether in compliance with  Environmental  Laws or
not,  other than in respect of those  matters set forth on Schedule 12.2 hereto,
or (iii) exposure of any person to any chemical substances, noises or vibrations
generated by the Company,  any of its  Subsidiaries,  or any of their respective
predecessors,  whether in compliance with  Environmental Laws or not, other than
in  respect  of those  matters  set forth on  Schedule  12.2  hereto;  provided,
however, that no indemnification shall be provided hereunder for any decrease in
the  market  price of the  shares  of  Common  Stock  purchased  or owned by the
Purchaser  or  any  of  its   Affiliates;   and  provided,   further,   that  no
indemnification shall be provided hereunder with respect to the preceding clause
12.2(b) to the extent an untrue or  alleged  untrue  statement  or  omission  or
alleged omission was made by the Company in reliance upon and in conformity with
information  furnished  by or on  behalf of the  Purchaser  for use in the Proxy
Statement. The Company shall reimburse any such Indemnified Person for all costs
and expenses  (including,  without  limitation,  reasonable  attorneys' fees and
disbursements and costs of investigation)  incurred in connection with preparing
for,  bringing or  defending  any action,  claim,  investigation,  suit or other
proceeding,  whether or not in connection with pending or threatened litigation,
which shall be caused by or related to or arise out of the foregoing, whether or
not such Indemnified Person shall be named as a party thereto.

     12.3 Purchaser Indemnity. The Purchaser hereby agrees to indemnify and hold
harmless each of the Company, and its directors, officers, employees and agents,
from and against any and all claims,  liabilities,  losses, damages and expenses
(including, without limitation, reasonable attorneys' fees and disbursements and
costs of  investigation)  asserted  against or incurred by any such  Indemnified
Person  which are  caused by or are  related  to or arise out of (a)  subject to
Section  11  hereof,  the  Purchaser's  material  breach of any  representation,
warranty,  covenant or agreement of the Purchaser contained in this Agreement or
(b) a  Violation  to the extent  that such  Violation  shall occur in respect of
information furnished to the Company by or on behalf of the Purchaser for use in
the

                                       A-26

<PAGE>

Proxy Statement.  The Purchaser shall reimburse any such Indemnified  Person for
all costs and expenses  (including,  without limitation,  reasonable  attorneys'
fees and disbursements  and costs of investigation)  incurred in connection with
preparing for, bringing or defending any action, claim,  investigation,  suit or
other  proceeding,  whether or not in  connection  with  pending  or  threatened
litigation,  which  shall  be  caused  by or  related  to or  arise  out  of the
foregoing,  whether  or not such  Indemnified  Person  shall be named as a party
thereto.

     12.4 Defense.  Promptly after receipt by an Indemnified Person of notice of
any claim or demand or the commencement of any suit, action or proceeding by any
third party with respect to which indemnification may be sought hereunder,  such
Indemnified  Person  shall  notify in writing  the  Indemnitor  of such claim or
demand or the commencement of such suit, action or proceeding, but failure so to
notify the Indemnitor  shall not relieve the Indemnitor from any liability which
the Indemnitor may have hereunder or otherwise,  unless the Indemnitor  shall be
actually  prejudiced  by such failure.  If the  Indemnitor  shall so elect,  the
Indemnitor  shall  assume the defense of such  claim,  demand,  action,  suit or
proceeding,  including the employment of counsel reasonably satisfactory to such
Indemnified Person, and shall pay the fees and disbursements of such counsel. In
the event, however, that such Indemnified Person shall reasonably determine that
having common  counsel would present such counsel with a conflict of interest or
alternative  defenses  shall be  available  to an  Indemnified  Person or if the
Indemnitor shall fail to assume the defense of the claim,  demand,  action, suit
or  proceeding  in a timely  manner,  then such  Indemnified  Person  may employ
separate  counsel to  represent  or defend such  Person  against any such claim,
demand,  action,  suit or proceeding and the Indemnitor shall pay the reasonable
fees and disbursements of such counsel;  provided,  however, that the Indemnitor
shall  not be  required  to pay the  fees  and  disbursements  of more  than one
separate  counsel for all Indemnified  Persons in any jurisdiction in any single
action, suit or proceeding.  For any claim,  demand,  action, suit or proceeding
the defense of which the Indemnitor shall assume,  the Indemnified  Person shall
have the right to  participate  therein  and to retain  its own  counsel at such
Indemnified Person's own expense (except as otherwise  specifically  provided in
this Section 12.4),  so long as such  participation  does not interfere with the
Indemnitor's  control of such claim,  demand,  action,  suit or proceeding.  The
Indemnitor  shall not,  without  the prior  written  consent of the  Indemnified
Person,  settle or  compromise  or consent to the entry of any  judgment  in any
pending or  threatened  claim,  action,  suit or  proceeding in respect of which
indemnification  may be sought hereunder  unless such settlement,  compromise or
consent shall include an unconditional  release of such Indemnified  Person from
all liability arising out of such claim, demand,  action, suit or proceeding and
would not prohibit,  restrict or impair the Indemnified  Person from engaging in
any business.

     12.5 Purchaser Claims. If there shall be any claim for  indemnification  by
the Purchaser  under this Section 12 or under the  Distribution  Agreement,  all
determinations by the Company relating thereto,  including,  without limitation,
the choice and  engagement of counsel,  the defense  and/or  prosecution  of any
action and the terms and  conditions of any  settlement  or compromise  thereof,
shall be made solely by the Company Designees (by majority vote thereof).

     12.6 Exclusive Remedy. The parties hereto agree that the sole and exclusive
remedy and recourse with respect to any and all claims, suits, actions, demands,
liabilities, losses, expenses and

                                       A-27

<PAGE>

damages  relating  to or arising  out of the  subject  matter of this  Agreement
(excluding  the  Distribution  Agreement and the Services  Agreements)  shall be
pursuant,  and  subject,  to the  indemnification  provisions  set forth in this
Section 12, subject to the provisions of Section 13.11 hereof and except for the
remedy of injunctive relief set forth in Section 13.12 hereof.

     SECTION 13. Miscellaneous.

     13.1  Expenses.  The  parties  shall  bear  their own  respective  expenses
(including,  but not  limited to, all fees and  expenses  of counsel,  financial
advisers  and   independent   accountants)   incurred  in  connection  with  the
preparation,   negotiation  and  execution  of  this  Agreement  and  the  other
agreements   referred  to  herein  and  the  consummation  of  the  transactions
contemplated  hereby and thereby. To the extent that a Company Designee shall be
required  to make any  determination  or take any action  hereunder  (including,
without limitation,  with respect to indemnification  under Section 12 hereof or
reviewing  the  compliance of the  Purchaser  with its covenants and  agreements
contained herein) in his/her capacity as a Company Designee, the Purchaser shall
cause the Company to, and the Company shall,  promptly  reimburse and/or pay any
reasonable  out-of-pocket expenses incurred by the Company Designee in acting in
such capacity.  The Company Designees are intended third-party  beneficiaries of
this provision.

     13.2 Assignment; Binding Effect. All terms and provisions of this Agreement
shall be binding  upon and inure to the benefit of the parties  hereto and their
respective  successors and permitted assigns, but neither this Agreement nor any
of the rights,  interests or obligations  hereunder may be assigned or delegated
by any party  hereto  without  the prior  written  consent  of the other  party;
provided,  that the Purchaser  shall have the right to designate an Affiliate of
the  Purchaser  to  purchase  and take  delivery  of the  Shares at the  Closing
pursuant to Section 1.1 hereof.  The obligations and agreements of the Purchaser
hereunder shall succeed to and bind any purchaser or transferee,  whether or not
such  purchaser or  transferee  shall be an Affiliate of the  Purchaser,  of the
Shares and/or the Option Shares,  but shall also remain binding on the Purchaser
if the transferee is an Affiliate thereof.  Notwithstanding  the foregoing,  the
Options shall be at all times nontransferable and nonassignable by the Purchaser
or Genpharm.

     13.3 Entire Agreement. This Agreement (including the Exhibits and Schedules
hereto) and the other agreements referred to herein or delivered pursuant hereto
contain the entire  agreement  between the parties  with  respect to the subject
matter   hereof  and   thereof  and   supersede   all  prior   arrangements   or
understandings,  written  or oral,  with  respect  thereto,  including,  without
limitation,  the  Confidentiality  Agreement,  dated  December 16, 1997,  by and
between the parties.  The parties hereto agree that the only representations and
warranties  made in connection  with the  transactions  contemplated  hereby and
thereby are those  expressly  made in writing in this  Agreement.  The Purchaser
expressly  disclaims reliance upon any  representations or warranties other than
those expressly made in writing by the Company in this Agreement.  The Purchaser
acknowledges  and agrees  that it is  sophisticated  in matters  concerning  the
subject  matter of this  Agreement  and the  business of the  Company,  that the
Purchaser and the Company have an ordinary business relationship

                                       A-28

<PAGE>

of seller-purchaser and that no special relationship of trust exists between the
Purchaser and the Company which could give rise to a special duty of care.

     13.4 Notices. All notices hereunder shall be in writing and shall be given:
(a) if to the  Company,  at One Ram Ridge Road,  Spring  Valley,  New York 10977
(attention:  Kenneth I. Sawyer,  President), fax number: (914) 425-5097, or such
other address or fax number as the Company  shall have  designated in writing to
the  Purchaser in  accordance  with this Section  13.4,  with a copy to Hertzog,
Calamari &  Gleason,  100 Park  Avenue,  New York,  New York  10017  (attention:
Stephen  Ollendorff,  Esq.  and Stephen R.  Connoni,  Esq.),  fax number:  (212)
213-1199,  or (b) if to the Purchaser,  at c/o Merck KGaA,  Frankfurter  Strasse
250, 64271 Darmstadt Germany (attention:  Dr. Rudi Neirinckx), fax number 011 49
6151 72 3435, or such other  address or fax number as the  Purchaser  shall have
designated in writing to the Company in accordance  with this Section 13.4, with
a copy to Coudert  Brothers,  1114 Avenue of the  Americas,  New York,  New York
10036-7703  (attention:  Edwin  S.  Matthews,  Jr.,  Esq.),  fax  number:  (212)
626-4120.  Any notice shall be deemed to have been given if personally delivered
or sent by express  commercial  courier  or  delivery  service  or by  telegram,
telefax, telex or facsimile  transmission.  Any notice given in any other manner
shall be deemed given when actually received.

     13.5 Amendments;  Waiver.  Prior to the Closing,  this Agreement may not be
amended or, subject to Section 13.11 hereof, terminated, and no provision hereof
may be waived,  except pursuant to a written instrument  executed by the Company
and the Purchaser.  For a period of three years  following the Closing,  neither
this Agreement nor the Distribution  Agreement may be amended,  and no provision
hereof or thereof may be waived, without the prior written consent of at least a
majority of the Company Designees (on behalf of the Company) and except pursuant
to a written instrument executed by both parties.

     13.6 Counterparts. This Agreement may be executed in counterparts, and each
such  counterpart  shall be deemed to be an  original  instrument,  but all such
counterparts together shall constitute but one agreement.

     13.7  Headings.  The headings of the sections of this  Agreement  have been
inserted for  convenience of reference only and shall not be deemed to be a part
of this Agreement. As used herein, the phrase "to the Company's knowledge" shall
mean the actual knowledge of any of the executive officers of the Company only.

     13.8 Governing  Law. This  Agreement  shall be governed by and construed in
accordance  with the laws of the State of New York  applicable to contracts made
and to be performed wholly therein.

     13.9  Severability.  If any term or  provision  hereof  shall be invalid or
unenforceable,   (i)  the  remaining  terms  and  provisions   hereof  shall  be
unimpaired,  (ii) any such invalidity or  unenforceability  in any  jurisdiction
shall not invalidate or render unenforceable such term or provision in any other
jurisdiction and (iii) the invalid or  unenforceable  term or provision shall be
deemed replaced by a term

                                       A-29

<PAGE>

or  provision  as  determined  by a court to be  valid  and  enforceable  and to
express, to the fullest extent legally permissible, the intention of the parties
with respect to the invalid or unenforceable term or provision.

     13.10 Consent to  Jurisdiction.  In  connection  with any dispute which may
arise  under this  Agreement  or under any other  agreement  referred  to herein
(except for the Distribution Agreement),  each of the parties hereby irrevocably
submits to, consents to, and waives any objection to the exclusive  jurisdiction
of the courts of the State of New York  located in the County of New York and of
the United  States  District  Court for the Southern  District of New York,  and
waives  any  objection  to the laying of venue in such  courts.  Each such party
admits that any such dispute may be resolved at least as  conveniently in such a
court as in any other court,  and shall not seek  dismissal or a change of venue
on the ground that  resolution  of such a dispute in any such court shall not be
convenient or in the interests of justice. The Purchaser hereby appoints Coudert
Brothers  as its agent upon whom  service  of process  may be made with the same
force and effect as if such  service  shall have been made  personally  upon the
Purchaser. The Company hereby appoints Hertzog,  Calamari & Gleason as its agent
upon whom  service of  process  may be made with the same force and effect as if
such service shall have been made personally upon the Company.

     13.11 Termination.

     (a) This  Agreement may be  terminated  and the  transactions  contemplated
hereby  may be  abandoned  at any time prior to the  Closing:  (i) by the mutual
written  consent of the Purchaser and the Company,  (ii) by either party to this
Agreement,  if the  Shareholders'  Approval  shall not have been  obtained  with
respect to each of the  Proposals at the  Meeting,  including  any  adjournments
thereof,  (iii) by either  party to this  Agreement,  if there shall have been a
material breach of a representation  or warranty  contained in this Agreement by
the other  party,  or a material  breach by the other  party of any  covenant or
agreement  set forth herein and such breach shall not have been cured within ten
(10) days following the occurrence thereof,  and such shall not have been waived
by the other  party  hereto,  (iv) by  either  party to this  Agreement,  if the
Closing shall not have  occurred by July 15, 1998 or (v) by the Company,  if the
Board of Directors of the Company  determines in good faith,  after consultation
with outside  counsel,  that failure to terminate this Agreement  would create a
substantial  risk  of  liability  for  breach  of its  fiduciary  duties  to the
Company's shareholders under applicable law.

     Upon any such  termination,  all further  obligations  of the parties shall
become null and void and no party shall have any  liability  to the other party,
except that the  obligations of the parties hereto pursuant to Sections 6.2, 6.3
and 13,  including  Section  13.11(b),  hereof shall  survive  such  termination
indefinitely.

     (b)  Notwithstanding  anything to the contrary  contained  herein,  if this
Agreement (i) is terminated by either party  pursuant to Section  13.11(a) (iii)
hereof,  then the breaching party shall promptly pay to the non-breaching  party
in cash an amount equal to $750,000, or (ii) is

                                       A-30

<PAGE>

terminated  by the Company  pursuant to Section  13.11(a)  (v) hereof,  then the
Company  shall  promptly  pay to the  Purchaser  in  cash  an  amount  equal  to
$1,000,000.  The  parties  acknowledge  and agree  that the  provisions  of this
Section 13.11(b) provide for liquidated damages (and not a penalty) and shall be
the sole and exclusive remedy and recourse of the parties hereto in respect of a
termination of this Agreement pursuant to Sections 13.11(a)(iii) or (v) hereof.

     13.12 Injunctive Relief.

     (a) The Purchaser hereby acknowledges and agrees that a breach by it of its
covenants or agreements  hereunder will cause  irreparable  harm to the Company.
Accordingly,  the Purchaser  acknowledges  and agrees that a remedy at law for a
breach  of its  obligations  hereunder  (including,  but  not  limited  to,  its
obligations under Sections 6.3, 7.3 and 8 hereof) will be inadequate and agrees,
in the event of a breach or threatened breach by the Purchaser of the provisions
of this Agreement  (including,  but not limited to, its obligations  pursuant to
Sections  6.3, 7.3 and 8 hereof),  that the Company and, in the case of Sections
7.3, 8.1, 8.5 and 8.6 hereof,  the  shareholders  of the Company (other than the
Purchaser)  and the Company  Designees,  shall be  entitled,  in addition to all
other available remedies, to an injunction  restraining any actual or threatened
breach and/or the remedy of specific performance.

     (b) The Company hereby  acknowledges  and agrees that a breach by it of its
covenants or agreements  hereunder will cause irreparable harm to the Purchaser.
Accordingly,  the  Company  acknowledges  and agrees  that a remedy at law for a
breach  of its  obligations  hereunder  (including,  but  not  limited  to,  its
obligations  under Sections 6.3 and 7 hereof) will be inadequate and agrees,  in
the event of a breach or threatened  breach by the Company of the  provisions of
this  Agreement  (including,  but not  limited to, its  obligations  pursuant to
Sections  6.3, 7.3 and 7.8 hereof),  that the  Purchaser  shall be entitled,  in
addition to all other  available  remedies,  to an  injunction  restraining  any
actual or threatened breach and/or the remedy of specific performance.


                                       A-31

<PAGE>



     IN WITNESS WHEREOF, each of the undersigned has caused this Agreement to be
executed as of the date first written above.



                                                  PHARMACEUTICAL RESOURCES, INC.


                                                  
                                                  By: Kenneth I. Sawyer
                                                     ___________________________
                                                     Name: Kenneth I. Sawyer 
                                                     Title: President


                                                  LIPHA AMERICAS, INC.


                                                  By: Rudi Neirinckx
                                                     ___________________________
                                                     Name: Rudi Neirinckx
                                                     Title: Head, New Business
                                                            Merck KGaA



                                      A- 32

<PAGE>

                                    Exhibit B

                                 [Letterhead of]
                             GRUNTAL CAPITAL MARKETS


March 25, 1998

Board of Directors
Pharmaceutical Resources, Inc.
One Ram Ridge Road
Spring Valley, NY 10977

Dear Sirs:

We understand that Pharmaceutical  Resources,  Inc. ("PAR" or the "Company") and
Lipha Americas, Inc., an affiliate of Merck KGaA (the "Purchaser"), have entered
into a Stock  Purchase  Agreement  (the  "Agreement"),  pursuant  to  which  the
Purchaser  will  purchase at closing  10,400,000  shares of common  stock of the
Company (the "Common  Stock") to be so1d by the Company at a per share  purchase
price of $2.00 (the  "Transaction").  We understand that, in connection with the
Agreement, among other things, (i) Merck KGaA and Clal Pharmaceutical Industries
Ltd. ("Clal") will enter into a stock purchase agreement pursuant to which Merck
KGaA will  purchase or have the right to purchase from Clal all shares of Common
Stock  beneficially  owned by Clal, the  consummation  of the purchase of common
shares of Common Stock pursuant to which  transaction is expected to occur at or
about  the  time of the  consummation  of the  Transaction  contemplated  by the
Agreement;  (ii) concurrently with the execution of this Agreement,  the Company
and an  affiliate  of Merck  KGaA are  entering  into a  distribution  agreement
pursuant  to  which  the  Company  shall  distribute  certain  products  of  the
Purchaser;  (iii)  concurrently with closing of the Transaction  contemplated by
the  Agreement,  the Company and Merck KGaA and an  affiliate of Merck KGaA will
enter into a service  agreements,  pursuant to which such companies shall render
certain  services  to the  Company  and (iv) in  connection  with  such  service
agreements the Company will execute and deliver to Purchaser a five-year options
to acquire an aggregate  of 1,171,040  additional  shares of Common  Stock.  The
terms and  conditions  of the  Transaction  are set forth in more  detail in the
Agreement.

You have  requested  our opinion as to the fairness to the  shareholders  of PAR
from a financial point of view of the terms of the Transaction.

In arriving at our opinion,  we have reviewed the Agreement and certain publicly
available  business  and  financial  information  relating  to PAR. We have also
reviewed certain other information,  including  financial  forecasts and related
information,  provided  to us by PAR and we have met with  PAR's  management  to
discuss the  business  and  prospects  of PAR. We have also  considered  certain
financial  and stock  market data of PAR,  and we have  compared  that data with
similar data for other publicly held companies in businesses similar to those of
PAR,  and we have  considered  the  financial  terms of certain  other  business
combinations  and other  transactions  which  have been  effected  or  currently
pending  which  we  have  deemed   relevant.   We  also  considered  such  other
information,  financial  studies,  analyses and  investigations  and  financial,
economic and market criteria which we deem relevant.

In  connection  with our  review,  we have not assumed  any  responsibility  for
independent  verification of any of the foregoing information and have relied on
it being  complete and accurate in all  material  respects.  With respect to the
financial forecasts,  we have assumed that they have been reasonably prepared on
bases reflecting the best currently  available estimates and judgments of PAR' s
management as to the future financial  performance of PAR. In addition,  we have
not made an  independent  evaluation  or appraisal of the assets or  liabilities
(contingent  or  otherwise)  of PAR,  nor have we been  furnished  with any such
evaluations  or  appraisals.  We have  discussed with counsel to PAR, and relied
upon their description of, all legal matters with respect to the Transaction.


                                       B-1

<PAGE>


Our opinion is  necessarily  based upon  financial,  economic,  market and other
conditions as they exist on, and the information made available to us as of, the
date hereof.  We have not been requested to opine upon, and our opinion does not
in any manner address,  PAR's underlying  business  decision to proceed with the
Transaction.  We will  receive a fee in  connection  with the  rendering of this
opinion.  In addition,  PAR has agreed to  indemnify us for certain  liabilities
arising out of our engagement in the rendering of this opinion.

As part of our  investment  banking  services,  we are regularly  engaged in the
valuation of businesses and securities in connection with mergers, acquisitions,
underwritings,  sales and  distributions  of  listed  and  unlisted  securities,
private placements and valuations for estate, corporate and other purposes.

In the ordinary course of our business, we and our affiliates may actively trade
the  equity  securities  of PAR for  our own  account  and for the  accounts  of
customers  and,  accordingly,  may at any time hold a long or short  position in
such  securities.  As you are aware, we also regularly  publish research reports
regarding  the  businesses  and  securities of  publicly-owned  companies in the
generic drug industry, including PAR.

It is understood  that this letter is for  information of the Board of Directors
of PAR in connection with its consideration of the Transaction. Our opinion does
not constitute a  recommendation  to any member of the Board of Directors or any
shareholder  as to how such member or  shareholder  should vote on the  proposed
Transaction  and is not to be quoted or referred to, in whole or in part, in any
registration statement,  prospectus or proxy statement, or in any other document
used in  connection  with the  offering  or sale of  securities,  nor shall this
letter  be used for  other  purposes,  without  our prior  written  consent.  We
understand  that this  opinion  will be filed with the  Securities  and Exchange
Commission and distributed to PAR's  shareholders as part of the Proxy Statement
related to the proposed Transaction.
We hereby consent to the foregoing use of the opinion.

Based upon and subject to the foregoing,  it is our opinion that, as of the date
hereof,  the terms of the  Transaction are fair, from a financial point of view,
to PAR.

                             Respectfully submitted,

                             Gruntal & Co., L.L.C.

                             By: /s/ Gruntal & Co., L.L.C.
                                ----------------------------





                                      B-2

<PAGE>
                      PRELIMINARY COPY-FOR SEC REVIEW ONLY
   
                         PHARMACEUTICAL RESOURCES, INC.
              Proxy for Annual Meeting To Be Held on June __, 1998
   
        This Proxy is being Solicited on Behalf of the Board of Directors

           Know All Men By These Presents:  That the undersigned  shareholder(s)
   P       of  Pharmaceutical  Resources,  Inc., a New Jersey  corporation  (the
           "Company"), hereby constitute(s) and appoint(s) Kenneth I. Sawyer and
   R       Dennis J.  O'Connor with full power of  substitution  in each, as the
           agents,  attorneys  and  proxies of the  undersigned,  for and in the
   O       name,  place  and  stead of the  undersigned,  to vote at the  Annual
           Meeting of Shareholders of the Company to be held at the Holiday Inn,
   X       Suffern,  Three Executive Boulevard,  Suffern, New York, on June ___,
           1998, at 10:00 a.m. (local time) and any adjournment(s)  thereof, all
   Y       of the shares of stock  which the  undersigned  would be  entitled to
           vote  if  then  personally  present  at such  meeting  in the  manner
           specified  and on any other  business as may properly come before the
           meeting. The undersigned would direct my (our) proxies to vote for me
           (us) as specified by a cross (X) in the appropriate  spaces, upon the
           following proposals:

           THIS PROXY WILL BE VOTED IN ACCORDANCE WITH THE INSTRUCTIONS GIVEN ON
           THE REVERSE SIDE. IF NO  INSTRUCTIONS  ARE GIVEN,  THIS PROXY WILL BE
           VOTED  FOR  EACH OF THE  FOLLOWING  PROPOSALS  AND,  AT THE  PROXIES'
           DISCRETION,  UPON ANY OTHER MATTERS THAT MAY PROPERLY COME BEFORE THE
           MEETING AND ANY ADJOURNMENT(S) THEREOF:



<PAGE>

_____     Please mark your
|   |     votes as in this
| X |     example
- -----

         This proxy when properly  executed will be voted in the manner directed
herein.  If no direction is made,  this proxy will be voted (i) FOR the election
of all listed nominees for director,  (ii) FOR the sale of 10,400,000  shares of
Common  Stock to Lipha  Americas,  Inc. and the grant and issuance of options to
purchase an  aggregate  of  1,171,040  shares of Common  Stock to Merck KGaA and
Genpharm  Inc.,  (iii)  FOR  the  approval  of an  amendment  to  the  Company's
Certificate  of  Incorporation  to increase the number of  authorized  shares of
Common  Stock,  (iv) FOR the approval and adoption of the 1997  Directors  Stock
Option Plan, and (v) at the discretion of the proxy holders,  in respect of such
other business as may properly come before the meeting and at any adjournment(s)
thereof.

  1.       Election of Directors.

           Nominees:
           Class I:      [to come]
           Class II      Kenneth I. Sawyer, Mark Auerbach, Stephen A. Ollendorff
           Class III:    [to come]
 .                                          For        Withhold Authority to
                                           All       Vote for all Nominees
                                                             Listed
                                          |----|   |-------------------------|
                                          |    |   |                         |
                                          |----|   |-------------------------|


(INSTRUCTION: To withhold authority to vote for any individual
nominee or nominees, write each nominee's name in the space below.)



2.       Approval of Stock Sale to Lipha       For      Against     Withheld
         Americas, Inc. and Grant and 
         Issuance of Options to Merck
         KGaA and Genpharm Inc.
                                              |----|   |------|    |--------|  
                                              |    |   |      |    |        |
                                              |----|   |------|    |--------|   


3.       Approval of Increase in Authorized    For      Against        Withheld
         Number of Common Stock
                                              |----|   |------|    |--------|  
                                              |    |   |      |    |        |
                                              |----|   |------|    |--------|   




<PAGE>




4.       Approval and Adoption of the 1997     For      Against        Withheld
         Directors Stock Option Plan
                                              |----|   |------|    |--------|  
                                              |    |   |      |    |        |
                                              |----|   |------|    |--------|   



5.        In their  discretion,  the proxy  holders are  authorized to vote upon
          such other  business as may  properly  come before the meeting and any
          adjournment(s)  thereof,  and as set  forth  in Rule  14a-4(c)  of the
          Securities Exchange Act of 1934, as amended.




                                        Please mark, sign, date and return this 
                                        proxy card promptly to allow adequate 
                                        time for mailing and processing prior to
                                        the meeting to be held on June   , 1998.


                                        __________________________________, 1998
                                        Signature                           Date


                                        __________________________________, 1998
                                        Signature if held jointly           Date


                                        Please sign exactly as name appears 
                                        hereon.  When shares are held by joint 
                                        tenants, both should sign.  When
                                        signing as attorney, executor, admini-
                                        strator, trustee or guardian, please 
                                        give full title as such.  If a 
                                        corporation, please sign in full
                                        corporate name by the president or other
                                        authorized officer.  If a partnership, 
                                        please sign in partnership name by an 
                                        authorized person.




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