AUTOIMMUNE INC
SC 13G/A, 1999-03-18
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549





                                  SCHEDULE 13G
                    Under the Securities Exchange Act of 1934
                               (Amendment No. 3)*




                                 AutoImmune Inc.
- -------------------------------------------------------------------------------
                                (Name of Issuer)


                          Common Stock, $0.01 par value
- -------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    052776101
- -------------------------------------------------------------------------------
                                 (CUSIP Number)
- -------------------------------------------------------------------------------

                                  March 8, 1999
- -------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

|_|  Rule 13d-1(b)
|X|  Rule 13d-1(c)
|_|  Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).




<PAGE>


                                       13G
- --------------------                                       --------------------
CUSIP No.  052776101                                        Page 2 of 19 Pages
- --------------------                                       --------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             Four Partners
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             New York
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             -0-
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          -0-
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      -0-
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      0%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      PN
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                       --------------------
CUSIP No.  052776101                                        Page 3 of 19 Pages
- --------------------                                       --------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             Andrew H. Tisch
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             505,500
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          505,500
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      505,500
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      3.1%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      IN
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                       --------------------
CUSIP No.  052776101                                        Page 4 of 19 Pages
- --------------------                                       --------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             Daniel R. Tisch
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             505,500
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          505,500
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      505,500
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      3.1%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      IN
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                       --------------------
CUSIP No.  052776101                                        Page 5 of 19 Pages
- --------------------                                       --------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             James S. Tisch
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             505,500
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          505,500
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      505,500
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      3.1%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      IN
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                       --------------------
CUSIP No.  052776101                                        Page 6 of 19 Pages
- --------------------                                       --------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             Thomas J. Tisch
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             505,500
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          505,500
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      505,500
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      3.1%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      IN
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                       --------------------
CUSIP No.  052776101                                        Page 7 of 19 Pages
- --------------------                                       --------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             The Andrew H. Tisch 1999 Annuity Trust III
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|
- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             505,500
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          505,500
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      505,500
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      3.1%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      OO
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                       --------------------
CUSIP No.  052776101                                        Page 8 of 19 Pages
- --------------------                                       --------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             The Daniel R. Tisch 1999 Annuity Trust III
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             505,500
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          505,500
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      505,500
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                          |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      3.1%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      OO
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                       --------------------
CUSIP No.  052776101                                        Page 9 of 19 Pages
- --------------------                                       --------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             The James S. Tisch 1999 Annuity Trust III
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             505,500
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          505,500
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      505,500
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                          |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      3.1%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      OO
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                       --------------------
CUSIP No.  052776101                                        Page 10 of 19 Pages
- --------------------                                       --------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             The Thomas J. Tisch 1999 Annuity Trust III
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             505,500
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          505,500
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      505,500
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      3.1%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      OO
- ------------ ------------------------------------------------------------------




<PAGE>


Item 1.

         (a) Name of Issuer

             AutoImmune Inc. (the "Issuer")

         (b) Address of Issuer's Principal Executive Offices

             128 Spring Street
             Lexington, Massachusetts  02173

Item 2.

         (a) Name of Persons Filing

         This Schedule 13G is being filed jointly by the following entities and
individuals:

         1. Four Partners, a New York general partnership ("FP");

         2. Andrew H. Tisch;

         3. Daniel R. Tisch;

         4. James S. Tisch;

         5. Thomas J. Tisch (Andrew H. Tisch, Daniel R. Tisch, James S. Tisch
and Thomas J. Tisch are referred to collectively as the "Messrs. Tisch");

         6. The Andrew H. Tisch 1999 Annuity Trust III ("Andrew Tisch GRAT
III");

         7. The Daniel R. Tisch 1999 Annuity Trust III ("Daniel Tisch GRAT
III");

         8. The James S. Tisch 1999 Annuity Trust III ("James Tisch GRAT III");
and

         9. The Thomas J. Tisch 1999 Annuity Trust III ("Thomas Tisch GRAT III";
and collectively with Andrew Tisch GRAT III, Daniel Tisch GRAT III and James
Tisch GRAT III, the "GRATs").

         The sole partners of FP are Andrew H. Tisch 1991 Trust, for which
Andrew H. Tisch is the managing trustee, Daniel R. Tisch 1991 Trust, for which
Daniel R. Tisch is the managing trustee, James S. Tisch 1991 Trust, for which
James S. Tisch is the managing trustee, and Thomas J. Tisch 1991 Trust, for
which Thomas J. Tisch is the managing trustee. Thomas J. Tisch has been
appointed the Manager of FP.

         Each of the GRATs is a grantor retained annuity trust in which the
grantor holds an annuity interest and in which the remainder interest was
created in favor of a trust or trusts for the grantor's offspring. Thomas J.
Tisch is the grantor and Andrew H. Tisch is the trustee of Thomas Tisch GRAT
III. Daniel R. Tisch is the grantor and James S. Tisch is the trustee of Daniel
Tisch GRAT III. James S. Tisch is the grantor and Thomas J. Tisch is




                                       11

<PAGE>

the trustee of James Tisch GRAT III. Andrew H. Tisch is the grantor and Daniel
R. Tisch is the trustee of Andrew Tisch GRAT III.

         On March 8, 1999, the following transfers occurred (the "GRAT
Transfers"):

         1. FP distributed all of the shares of common stock, $0.01 par value
per share, of AutoImmune Inc. ("Common Stock") it owned in equal shares of
505,500 each to the four trusts that are partners of FP;

         2. Each of the four trusts that are partners of FP distributed all of
the 505,500 shares of Common Stock that it had received from FP to the Mr. Tisch
who is the beneficiary of such trust;

         3. Each of the Messrs. Tisch contributed all of the 505,500 shares of
Common Stock that he had received to the GRAT for which he is the grantor.

         None of the GRAT Transfers was a "sale" for purposes of the Securities
Act of 1933, as amended (the "Securities Act"), or the Securities Exchange Act
of 1934, as amended (the "Exchange Act"), and collectively represented only a
change in the form of beneficial ownership of the shares of Common Stock and not
an actual change in the beneficial ownership of such shares of Common Stock.

         (b) Address of Principal Business Office or, if none, Residence

             The mailing address of FP is:
  
             c/o Thomas J. Tisch
             667 Madison Avenue
             New York, NY  10021

             The mailing address for each of the GRATs is:

             c/o Mr. Barry Bloom
             655 Madison Avenue - 8th Floor
             New York, NY  10021

             The addresses of the Messrs. Tisch are:

             Name                               Business Address
             ----                               ----------------
             Andrew H. Tisch                    667 Madison Avenue
                                                New York, NY 10021

             Daniel R. Tisch                    c/o Mentor Partners, L.P.
                                                499 Park Avenue
                                                New York, NY 10022




                                       12

<PAGE>


             James S. Tisch                     667 Madison Avenue
                                                New York, NY 10021

             Thomas J. Tisch                    667 Madison Avenue
                                                New York, NY 10021

         (c) Citizenship

             FP is a New York general partnership.

             The Messrs. Tisch are brothers and are United States citizens.

         (d) Title of Class of Securities

             Common Stock, $0.01 par value

         (e) CUSIP Number

             052776101

Item 3.      If this statement is filed pursuant to Rule 13d-1(b), or
             13d-2(b) or (c), check whether the person filing is a:

         (a) |_| Broker or Dealer registered under Section 15 of the Act,

         (b) |_| Bank as defined in Section 3(a)(6) of the Act,

         (c) |_| Insurance company as defined in Section 3(a)(19) of the Act,

         (d) |_| Investment company registered under section 8 of the Investment
                 Company Act of 1940,

         (e) |_| Investment Adviser registered under section 203 of the
                 Investment Advisers Act of 1940,

         (f) |_| An employee benefit plan, Pension Fund which is subject to the
                 provisions of the Employee Retirement Income Security Act of
                 1974 or Endowment Fund; see ss. 240.13d-1(b)(1)(ii)(F),

         (g) |_| A parent holding company, in accordance with ss.
                 240.13d-1(b)(ii)(G) (Note: See Item 7),

         (h) |_| A savings association as defined in Section 3(b) of the Federal
                 Deposit Insurance Act (12 U.S.C. 1813);

         (i) |_| A church plan that is excluded from the definition of an
                 investment company under section 3(c)(14) of the Investment
                 Company Act of 1940 (15 U.S.C. 80a-3);

         (j) |_| Group, in accordance with ss. 240.13d-1(b)(1)(ii)(J).

  If this statement is filed pursuant to ss. 240.13d-1(c), check this box  |X|.




                                       13
<PAGE>


Item 4.       Ownership

         (a-b) Amount Beneficially Owned and Percent of Class

Each GRAT owns 505,500 shares of Common Stock.

Set forth in the table below is the aggregate number of shares of Common Stock
beneficially owned as of the date hereof by each person or entity listed in Item
2 above, together with the percentage of outstanding shares of Common Stock
which is beneficially owned by each such person or entity.

Name of                       Amount and Nature of                  % of Class
Beneficial Owner              Beneficial Ownership              Outstanding (1)
- ----------------              --------------------              ---------------

Four Partners                              0                          0%
Andrew H. Tisch 1991 Trust                 0                          0%
Daniel R. Tisch 1991 Trust                 0                          0%
James S. Tisch 1991 Trust                  0                          0%
Thomas J. Tisch 1991 Trust                 0                          0%
Andrew Tisch GRAT III                505,500                          3.1%
Daniel Tisch GRAT III                505,500                          3.1%
James Tisch GRAT III                 505,500                          3.1%
Thomas Tisch GRAT III                505,500                          3.1%
Andrew H. Tisch                      505,500 (2)                      3.1%
Daniel R. Tisch                      505,500 (2)                      3.1%
James S. Tisch                       505,500 (2)                      3.1%
Thomas J. Tisch                      505,500 (2)                      3.1%
                                     -------                          ---
Total                              2,022,000                         12.2%  (1)






(1)    The ownership percentages set forth in the table above are based on
       16,548,995 shares of Common Stock outstanding as of November 6, 1998,
       which information was reported on the Issuer's Form 10-Q for the quarter
       ended September 30, 1998.

(2)    Each of the Messrs. Tisch is herein reporting beneficial ownership of the
       shares of Common Stock owned by the GRAT for which he is trustee.




                                       14
<PAGE>


         (c) Set forth in the table below is information with respect to the
number of shares of Common Stock beneficially owned as of the date hereof by
each person or entity named in Item 2 above, indicating, with respect to such
shares of Common Stock, whether each such person has the sole power to vote or
direct the vote or shared power to vote or direct the vote and sole power to
dispose or direct the disposition or shared power to dispose or direct the
disposition.

Name of                         Power to Vote or            Power to Dispose or
Reporting Person                 Direct the Vote         Direct the Disposition
- ----------------                ----------------         ----------------------
                                Sole        Shared         Sole         Shared
                                ----        ------         ----         ------
Four Partners                    0            0             0             0
Andrew H. Tisch 1991 Trust       0            0             0             0
Daniel R. Tisch 1991 Trust       0            0             0             0
James S. Tisch 1991 Trust        0            0             0             0
Thomas J. Tisch 1991 Trust       0            0             0             0
Andrew Tisch GRAT III         505,500         0          505,500          0
Daniel Tisch GRAT III         505,500         0          505,500          0
James Tisch GRAT III          505,500         0          505,500          0
Thomas Tisch GRAT III         505,500         0          505,500          0
Andrew H. Tisch (1)           505,500         0          505,500          0
Daniel R. Tisch (1)           505,500         0          505,500          0
James S. Tisch (1)            505,500         0          505,500          0
Thomas J. Tisch (1)           505,500         0          505,500          0
- --------------------

(1)    By virtue of their status as trustees of the respective GRATs, the
       Messrs. Tisch may be deemed to have power to vote or direct the vote of
       the securities owned by those GRATs and power to dispose or direct the
       disposition of the securities owned by those GRATs.

Item 5.       Ownership of Five Percent or Less of a Class

              As a result of the GRAT Transfers, FP is no longer the beneficial
              owner of any shares of Common Stock. Beneficial ownership of the
              shares of Common Stock previously held by FP is herein reported by
              the Messrs. Tisch and the GRATs.

Item 6.       Ownership of More than Five Percent on Behalf of Another Person

              Not applicable.




                                       15

<PAGE>


Item 7.       Identification and Classification of the Subsidiary Which
              Acquired the Security Being Reported on By the Parent Holding
              Company

              Not applicable.

Item 8.       Identification and Classification of Members of the Group

              Not applicable.

Item 9.       Notice of Dissolution of Group

              Not applicable.

Item 10.      Certification

                    By signing below I certify that, to the best of my knowledge
              and belief, the securities referred to above were not acquired and
              are not held for the purpose of or with the effect of changing or
              influencing the control of the issuer of such securities and were
              not acquired and are not held in connection with or as a
              participant in any transaction having that purpose or effect.




                                       16
<PAGE>


                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

March 17, 1999                    FOUR PARTNERS

                                  By    /s/ Thomas J. Tisch
                                    --------------------------------------
                                    Thomas J. Tisch, Manager


                                        /s/ Andrew H. Tisch
                                    --------------------------------------
                                            Andrew H. Tisch


                                        /s/ Daniel R. Tisch
                                    --------------------------------------
                                            Daniel R. Tisch


                                        /s/ James S. Tisch
                                    --------------------------------------
                                            James S. Tisch


                                        /s/ Thomas J. Tisch
                                    --------------------------------------
                                            Thomas J. Tisch

                                  THE ANDREW H. TISCH 1999 ANNUITY TRUST III

                                   By    /s/ Daniel R. Tisch
                                     -------------------------------------
                                    Daniel R. Tisch, Trustee


                                  THE DANIEL R. TISCH 1999 ANNUITY TRUST III

                                  By    /s/ James S. Tisch
                                     -------------------------------------
                                     James S. Tisch, Trustee


                                  THE JAMES S. TISCH 1999 ANNUITY TRUST III

                                  By    /s/ Thomas J. Tisch
                                     -------------------------------------
                                     Thomas J. Tisch, Trustee


                                  THE THOMAS J. TISCH 1999 ANNUITY TRUST III

                                  By    /s/ Andrew H. Tisch
                                     -------------------------------------
                                     Andrew H. Tisch, Trustee




                                       17
<PAGE>


                                    AGREEMENT


         In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act
of 1934, as amended, the undersigned hereby agree that this Schedule 13G dated
March 17, 1999 relating to the Common Stock, $0.01 par value per share, of
AutoImmune Inc., as the same may be amended from time to time hereafter, is
being filed with the Securities and Exchange Commission on behalf of each of
them.

Dated:  March 17, 1999



                                  FOUR PARTNERS

                                  By    /s/ Thomas J. Tisch
                                    --------------------------------------
                                    Thomas J. Tisch, Manager


                                        /s/ Andrew H. Tisch
                                    --------------------------------------
                                            Andrew H. Tisch


                                        /s/ Daniel R. Tisch
                                    --------------------------------------
                                            Daniel R. Tisch


                                        /s/ James S. Tisch
                                    --------------------------------------
                                            James S. Tisch


                                        /s/ Thomas J. Tisch
                                    --------------------------------------
                                            Thomas J. Tisch

                                  THE ANDREW H. TISCH 1999 ANNUITY TRUST III

                                  By    /s/ Daniel R. Tisch
                                    --------------------------------------
                                    Daniel R. Tisch, Trustee


                                  THE DANIEL R. TISCH 1999 ANNUITY TRUST III

                                  By    /s/ James S. Tisch
                                    --------------------------------------
                                    James S. Tisch, Trustee




                                       18

<PAGE>


                                  THE JAMES S. TISCH 1999 ANNUITY TRUST III

                                  By    /s/ Thomas J. Tisch
                                    --------------------------------------
                                    Thomas J. Tisch, Trustee


                                  THE THOMAS J. TISCH 1999 ANNUITY TRUST III

                                  By    /s/ Andrew H. Tisch
                                    --------------------------------------
                                    Andrew H. Tisch, Trustee




                                       19


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