INCYTE PHARMACEUTICALS INC
S-3MEF, 1997-07-30
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>   1
      AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JULY 30, 1997
                                                  REGISTRATION NO. 333-________
===============================================================================


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                 ---------------

                                    FORM S-3

                             REGISTRATION STATEMENT
                                      Under
                           THE SECURITIES ACT OF 1933
                                 ---------------

                          INCYTE PHARMACEUTICALS, INC.
             (Exact name of registrant as specified in its charter)
<TABLE>
<S>                                                                                <C>       
                        Delaware                                                   94-3136539
(State or other jurisdiction of incorporation or organization)        (I.R.S. Employer Identification No.)
</TABLE>

                                3174 Porter Drive
                           Palo Alto, California 94304
                                 (415) 855-0555
  (Address, including zip code, and telephone number, including area code, of
                   registrant's principal executive offices)

                                ROY A. WHITFIELD
                             Chief Executive Officer
                          Incyte Pharmaceuticals, Inc.
                                3174 Porter Drive
                           Palo Alto, California 94304
                                 (415) 855-0555
            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)
                                 ---------------
                                   Copies to:
<TABLE>
<S>                                                                   <C> 


                      STANTON D. WONG                                           DAVID J. SEGRE
                      SALLY BRAMMELL                                            ADAM R. DOLINKO
                     BARBARA M. LANGE                                             AMY E. REES
               Pillsbury Madison & Sutro LLP                           Wilson Sonsini Goodrich & Rosati
                       P.O. Box 7880                                       Professional Corporation
              San Francisco, California 94120                                 650 Page Mill Road
                                                                          Palo Alto, California 94304
</TABLE>


                                 ---------------

        APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:
  As soon as practicable after this Registration Statement becomes effective.

     If the only securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box. / /

     If any of the securities being registered on this Form are to be offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. / /

     If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. /X/ 333-31307

     If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. / / ______

     If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. / /

                         CALCULATION OF REGISTRATION FEE
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<CAPTION>
<S>                                         <C>                    <C>                     <C>                  <C>         
===================================================================================================================================
                                                                      PROPOSED                PROPOSED
                                                                       MAXIMUM                 MAXIMUM
TITLE OF EACH CLASS OF SECURITIES TO BE      AMOUNT TO BE          OFFERING PRICE             AGGREGATE           AMOUNT OF
              REGISTERED                    REGISTERED(1)           PER SHARE(2)          OFFERING PRICE(2)   REGISTRATION FEE
- -----------------------------------------------------------------------------------------------------------------------------------
Common Stock, $.001 par value . . .         227,713 shares             $62.875               $14,317,455           $4,339
===================================================================================================================================
</TABLE>


(1)  Includes 27,713 shares that the Underwriters have the option to purchase to
     cover over-allotments, if any.

(2)  Estimated solely for the purpose of calculating the registration fee
     pursuant to Rule 457(c) based upon the average of the high and low prices
     of the Company's Common Stock on the Nasdaq National Market on July 23,
     1997.

================================================================================

<PAGE>   2





                INCORPORATION OF CERTAIN INFORMATION BY REFERENCE

        This Registration Statement is filed with the Securities and Exchange
Commission (the "Commission") under the Securities Act of 1933, as amended (the
"Act") by Incyte Pharmaceuticals, Inc. (the "Company"), pursuant to Rule 462(b)
under the Act. This Registration Statement incorporates by reference the
contents of the Registration Statement on Form S-3 (File No. 333-31307) relating
to the offering of up to 1,150,000 shares of Common Stock of the Company.



                                  CERTIFICATION

        The Company hereby certifies to the Commission that (i) it has
instructed its bank to pay the Commission the filing fee set forth on the cover
page of this Registration Statement by a wire transfer of such amount to the
Commission's account at Mellon Bank as soon as practicable (but no later than
the close of business on July 31, 1997), (ii) it will not revoke such
instructions, (iii) it has sufficient funds in the relevant account to cover the
amount of such filing fee, and (iv) it will confirm receipt of such instructions
by the bank during regular business hours on July 31, 1997.


                                        2





<PAGE>   3



                                   SIGNATURES

        Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3, and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Palo Alto, State of California, on July 30,
1997.

                     
                                    INCYTE PHARMACEUTICALS, INC.



                                    By        RANDAL W. SCOTT
                                       -----------------------------------
                                               Randal W. Scott
                                            President and Secretary

        Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>
                   Name                                          Title                                    Date
                   ----                                          -----                                    ----



<S>                                            <C>                                                   <C> 
                     *
- ------------------------------------------     Chief Executive Officer (Principal                     July 30, 1997
             Roy A. Whitfield                  Executive Officer) and Director



                     *                         Executive Vice President, Chief
- ------------------------------------------     Financial Officer and Treasurer                        July 30, 1997
             Denise M. Gilbert                 (Principal Financial Officer)


                                               Director of Finance and
                     *                         Administration (Principal Accounting                   July 30, 1997
- ------------------------------------------     Officer)
               Janet L. Nibel                   



                     *                                                                                July 30, 1997
- -----------------------------------------      Chairman of the Board
           Jeffrey J. Collinson                



                     *                                                                                July 30, 1997
- -----------------------------------------      Director
              Barry M. Bloom                   



                     *                                                                                July 30, 1997
- -----------------------------------------      Director
            Frederick B. Craves                


                     *                                                                                July 30, 1997
- -----------------------------------------      Director
                Jon S. Saxe                    



              RANDAL W. SCOTT                                                                         July 30, 1997
- -----------------------------------------      Director
               Randal W. Scott                  



*By         RANDAL W. SCOTT
   --------------------------------------    
            Randal W. Scott
           Attorney-in-Fact
</TABLE>

                                         
                                        3





<PAGE>   4
                                  EXHIBIT INDEX


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<CAPTION>
EXHIBIT                                                                                         SEQUENTIALLY
NUMBER                 DESCRIPTION OF DOCUMENT                                                  NUMBERED PAGE
- ------                 -----------------------                                                  -------------
<S>                   <C>                                                                       <C>

5.1                    Opinion of Pillsbury Madison & Sutro LLP (incorporated by reference
                       to Exhibit 5.1 to the Registrant's Registration Statement on Form S-3
                       (File No. 333-31037)).

23.1                   Consent of Ernst & Young LLP.                                                  5

23.2                   Consent of Pillsbury Madison & Sutro LLP (included in its
                       opinion filed as Exhibit 5.1 to this Registration
                       Statement).
</TABLE>

<PAGE>   1
                                                                   EXHIBIT 23.1

               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

        We consent to the incorporation by reference in this Registration
Statement on Form S-3 of Incyte Pharmaceuticals, Inc. for the registration of
227,713 shares of its common stock of our report dated February 7, 1997, with
respect to the consolidated financial statements of Incyte Pharmaceuticals,
Inc. included in its Annual Report (Form 10-K) for the year ended December 31,
1996 and to the reference of our firm under the captions "Selected Financial
Data" and "Experts" which are all included in the Registration Statement on
Form S-3 of Incyte Pharmaceuticals, Inc. (No. 333-31307) and incorporated by
reference in this Registration Statement.

                                        /s/ ERNST & YOUNG LLP

Palo Alto, California
July 29, 1997


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