INCYTE GENOMICS INC
S-8, EX-5.1, 2000-10-03
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                                                     EXHIBIT 5.1
                                                                     -----------




                   [PILLSBURY MADISON & SUTRO LLP LETTERHEAD]

                                 October 2, 2000


Incyte Genomics, Inc.
3160 Porter Drive
Palo Alto, CA 94304


         Re:   Registration Statement on Form S-8


Ladies and Gentlemen:

         With reference to the Registration Statement on Form S-8 to be filed by
Incyte Genomics, Inc., a Delaware corporation (the "Company"), with the
Securities and Exchange Commission under the Securities Act of 1933, as amended,
relating to 2,600,000 shares of the Company's Common Stock (the "Shares")
issuable pursuant to the Company's 1991 Stock Plan, as amended (the "Stock
Plan"), it is our opinion that the Shares have been duly authorized and, when
issued and sold in accordance with the Stock Plan, will be validly issued, fully
paid and nonassessable.

         We hereby consent to the filing of this opinion with the Securities and
Exchange Commission as Exhibit 5.1 to the Registration Statement.

                                Very truly yours,

                                /s/ PILLSBURY MADISON & SUTRO LLP




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