EPIGEN INC /DE
SC 13D/A, 1998-11-05
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>   1


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                              --------------------


                                  SCHEDULE 13D
                                 (RULE 13D-101)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
            TO RULE 13D-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
                                  RULE 13D-2(a)

                                (AMENDMENT NO. 4)


                                 Epigen, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                                 Common Stock
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)



                                   294259 10 G
- --------------------------------------------------------------------------------
                                  CUSIP Number



        Donald C. Fresne, North Tower Hill Rd., Box L, Millbrook NY 12545
                                 (914) 677-5317
- --------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)



                                 August 31, 1998
- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

     If the filing person has previously filed a statement on Schedule 13G to
report the acquisition that is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the
following box [ ].

     Note: Schedules filed in paper format shall include a signed original and
five copies of the schedule, including all exhibits. See Rule 13d-7(b) for other
parties to whom copies are to be sent.

                         (continued on following pages)

                               Page 1 of 3 Pages)


<PAGE>   2



CUSIP NO. 294259 10 G                  13D                 Page 2 of 3 Pages
- --------------------------------------------------------------------------------
1.  NAMES OF REPORTING PERSONS  Donald C. Fresne
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

- --------------------------------------------------------------------------------
2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                (a) [ ]
                                                                     (b) [ ]

- --------------------------------------------------------------------------------
3.  SEC USE ONLY

- --------------------------------------------------------------------------------
4.  SOURCE OF FUNDS*  

    00
- --------------------------------------------------------------------------------
5.  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM
    2(d) or 2(e)                                                         [ ]

- --------------------------------------------------------------------------------
6.  CITIZENSHIP OR PLACE OF ORGANIZATION  United States

- --------------------------------------------------------------------------------
                       7.  SOLE VOTING POWER  
                           2,349,873
NUMBER OF SHARES    ------------------------------------------------------------
 BENEFICIALLY          8.  SHARED VOTING POWER  
   OWNED BY                0
    EACH            ------------------------------------------------------------
  REPORTING            9.  SOLE DISPOSITIVE POWER 
   PERSON                  2,349,873
    WITH            ------------------------------------------------------------
                      10. SHARED DISPOSITIVE POWER  
                           0
- --------------------------------------------------------------------------------
11. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 
    2,349,873
- --------------------------------------------------------------------------------
12. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
    CERTAIN SHARES*                                                      [ ]
- --------------------------------------------------------------------------------
13. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 
    51.14%
- --------------------------------------------------------------------------------
14. TYPE OF REPORTING PERSON*  
    IN
- --------------------------------------------------------------------------------

<PAGE>   3


CUSIP NO. 294259 10 G                 13D                  Page 3 of 3 Pages


                                    SIGNATURE


     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


                                             August 31, 1998
                                             -----------------------------------
                                                 (Date)


                                             /s/ Donald C. Fresne
                                             -----------------------------------
                                                  (Signature)


                                             Donald C. Fresne, Chairman of
                                             the Board, President and Chief
                                             Executive Officer
                                             -----------------------------------
                                                 (Name/Title)



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