SEVIN ROSEN FUND IV LP
SC 13G/A, 1998-02-17
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                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  ------------

                                  SCHEDULE 13G
                                 (RULE 13d-102)

                           INFORMATION TO BE INCLUDED
                         IN STATEMENTS FILED PURSUANT TO
                      RULES 13D-1(b) AND (c) AND AMENDMENTS
                         THERETO FILED PURSUANT TO 13d-2

                               (AMENDMENT NO. 1)*

                                  ARQULE, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                                     COMMON
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   042 69E 107
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

                          ---------------------------

            *The  remainder  of  this  cover  page  shall  be  filled  out for a
reporting person's initial filing on this form with respect to the subject class
of securities,  and for any subsequent  amendment  containing  information which
would alter the disclosures provided in a prior cover page.

            The  information  required in the remainder of this cover page shall
not be deemed to be "filed"  for the  purpose  of  Section 18 of the  Securities
Exchange Act of 1934 or otherwise  subject to the liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however,  See
the NOTES).


<PAGE>

CUSIP 042 69E 107             13G                 Page 2 of 13

- --------------------------------------------------------------------------------
1      NAMES OF REPORTING PERSONS
       I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

       Sevin Rosen Fund IV L.P.
- --------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*       (a) [   ]
                                                                (b) [   ]


- --------------------------------------------------------------------------------
3       SEC USE ONLY


- --------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

       Delaware
- --------------------------------------------------------------------------------
                         
   NUMBER OF SHARES      5      SOLE VOTING POWER
 BENEFICIALLY OWNED              658,113
 BY EACH REPORTING
   PERSON WITH
                         -------------------------------------------------------
                         6      SHARED VOTING POWER
                                24,421
                         -------------------------------------------------------
                         7      SOLE DISPOSITIVE POWER
                                658,113
                         -------------------------------------------------------
                         8       SHARED DISPOSITIVE POWER
                                 24,421
- --------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        682,534
- --------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                                     :


- --------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)


        5.7%
- --------------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*


        PN
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



<PAGE>

CUSIP 042 69E 107             13G                 Page 3 of 13

- --------------------------------------------------------------------------------
1      NAMES OF REPORTING PERSONS
       I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

       SRB Associates IV L.P.
- --------------------------------------------------------------------------------
2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*       (a)   [   ]
                                                                (b)   [   ]

- --------------------------------------------------------------------------------
3       SEC USE ONLY


- --------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

       Delaware
- --------------------------------------------------------------------------------

  NUMBER OF SHARES       5    SOLE VOTING POWER
 BENEFICIALLY OWNED           658,113
 BY EACH REPORTING
   PERSON WITH
                         -------------------------------------------------------
                         6    SHARED VOTING POWER
                              24,421
                         -------------------------------------------------------
                         7    SOLE DISPOSITIVE POWER
                              658,113
                         -------------------------------------------------------
                         8    SHARED DISPOSITIVE POWER
                              24,421
- --------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        682,534
- --------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                               :

- --------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)


        5.7%
- --------------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*


       PN
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

CUSIP 042 69E 107             13G                 Page 4 of 13

- --------------------------------------------------------------------------------
1      NAMES OF REPORTING PERSONS
       I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

       Jon W. Bayless
- --------------------------------------------------------------------------------
2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*      (a)  [   ]
                                                              (b)  [   ]


- --------------------------------------------------------------------------------
3      SEC USE ONLY


- --------------------------------------------------------------------------------
4      CITIZENSHIP OR PLACE OF ORGANIZATION

       U.S.
- --------------------------------------------------------------------------------
                    
  NUMBER OF SHARES            5    SOLE VOTING POWER
 BENEFICIALLY OWNED                50,611
 BY EACH REPORTING
   PERSON WITH
                    ------------------------------------------------------------
                              6     SHARED VOTING POWER
                                    682,534
                    ------------------------------------------------------------
                              7     SOLE DISPOSITIVE POWER
                                    50,611
                    ------------------------------------------------------------
                              8     SHARED DISPOSITIVE POWER
                                    682,534
- --------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        733,145
- --------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                           :


- --------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)


        6.1%
- --------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*


        IN
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


CUSIP 042 69E 107                  13G                  Page 5 of 13


- --------------------------------------------------------------------------------
1      NAMES OF REPORTING PERSONS
       I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

       Stephen M. Dow
- -------------------------------------------------------------------------------
2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)   [   ]
                                                                (b)   [   ]


- --------------------------------------------------------------------------------
3       SEC USE ONLY


- --------------------------------------------------------------------------------
4       CITIZENSHIP OR PLACE OF ORGANIZATION

       U.S.
- --------------------------------------------------------------------------------
                   
  NUMBER OF SHARES        5   SOLE VOTING POWER
 BENEFICIALLY OWNED           6,000
 BY EACH REPORTING
   PERSON WITH
                   -------------------------------------------------------------
                          6   SHARED VOTING POWER
                              740,848
                   -------------------------------------------------------------
                         7    SOLE DISPOSITIVE POWER
                              6,000
                   -------------------------------------------------------------
                         8    SHARED DISPOSITIVE POWER
                              740,848
- --------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        746,848
- --------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                           :


- --------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)


        6.2%
- --------------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*


       IN
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

CUSIP 042 69E 107                  13G                 Page 6 of 13


- -------------------------------------------------------------------------------
1      NAMES OF REPORTING PERSONS
       I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

       John V. Jaggers
- -------------------------------------------------------------------------------
2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  [   ]
                                                                (b)  [   ]


- --------------------------------------------------------------------------------
3      SEC USE ONLY


- --------------------------------------------------------------------------------
4      CITIZENSHIP OR PLACE OF ORGANIZATION

       U.S.
- --------------------------------------------------------------------------------
                   
  NUMBER OF SHARES         5      SOLE VOTING POWER
 BENEFICIALLY OWNED               37,693
 BY EACH REPORTING
   PERSON WITH
                   -------------------------------------------------------------
                           6       SHARED VOTING POWER
                                   682,534
                   -------------------------------------------------------------
                           7        SOLE DISPOSITIVE POWER
                                    37,693
                   -------------------------------------------------------------
                           8        SHARED DISPOSITIVE POWER
                                    682,534
- --------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        720,227
- --------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                           :


- --------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)


        6.0%
- --------------------------------------------------------------------------------
12      TYPE OF REPORTING PERSON*


        IN
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

CUSIP 042 69E 107                  13G                      Page 7 of 13

- --------------------------------------------------------------------------------
1      NAMES OF REPORTING PERSONS
       I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

       Charles H. Phipps
- --------------------------------------------------------------------------------
2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*       (a)  [   ]
                                                               (b)  [   ]


- --------------------------------------------------------------------------------
3      SEC USE ONLY


- --------------------------------------------------------------------------------
4      CITIZENSHIP OR PLACE OF ORGANIZATION

       U.S.
- --------------------------------------------------------------------------------
                   
  NUMBER OF SHARES       5    SOLE VOTING POWER
 BENEFICIALLY OWNED           44,066
 BY EACH REPORTING
   PERSON WITH
                   -------------------------------------------------------------
                         6    SHARED VOTING POWER
                              686,784
                   -------------------------------------------------------------
                         7    SOLE DISPOSITIVE POWER
                              44,066
                   -------------------------------------------------------------
                         8    SHARED DISPOSITIVE POWER
                              686,784
- --------------------------------------------------------------------------------
9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        730,850
- --------------------------------------------------------------------------------
10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                           :


- --------------------------------------------------------------------------------
11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)


        6.1%
- --------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*


         IN
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>



ITEM 1.
            (A)  NAME OF ISSUER.

            ArQule, Inc., a Delaware corporation (the "Issuer").

            (B)  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES.

            The Issuer's principal executive offices are located at  200  Boston
Avenue, Medford, Massachusetts  02155.

ITEM 2.

            (A) NAMES OF PERSONS FILING.

            This statement is filed by the following persons:  (i)  Sevin  Rosen
Fund  IV  L.P.  ("SR  IV"); (ii)  SRB  Associates  IV  L.P.  ("SRB IV");   (iii)
Jon  W.  Bayless  ("Bayless");  (iv) Stephen M. Dow ("Dow"); (v) John V. Jaggers
("Jaggers");  and  (vi)  Charles  H.  Phipps  ("Phipps).   SRB IV is the general
partner of SR IV.  Bayless, Dow, Jaggers and Phipps are the general partners  of
SRB IV.

            (B)  ADDRESS OF PRINCIPAL BUSINESS OFFICE.

            The  principal  business  office of each of SR IV, SRB IV,  Bayless,
Jaggers,  and Phipps is Two Galleria Tower, 13455 Noel Road, Suite 1670, Dallas,
Texas 75240.  The principal  business office of Dow is 550 Lytton Avenue,  Suite
200, Palo Alto, California 94301.

            (C)  CITIZENSHIP.

            SR IV and SRB IV are each Delaware  limited  partnerships.  Bayless,
Dow, Jaggers and Phipps are each U.S. citizens.

            (D) TITLE OF CLASS OF SECURITIES.

            This statement relates to shares of Common Stock, par value $.01 per
share (the "Common Stock"), of the Issuer.


                                  Page 8 of 13
<PAGE>


            (E)  CUSIP NUMBER.

            042 69E 107

ITEM 3.

            This  statement  is not being  filed  pursuant  to Rule  13d-1(b) or
13d-2(b).

ITEM 4.     OWNERSHIP.1

            (A)  AMOUNT BENEFICIALLY OWNED.

                  (i)   Each  of SR IV are  SRB  IV  beneficially  owns  682,534
                        shares of Common Stock.

                  (ii)  Bayless  beneficially  owns  733,145  shares  of  Common
                        Stock.

                  (iii) Dow  beneficially  owns  746,848 shares of Common Stock.

                  (iv)  Jaggers  beneficially  owns  720,227  shares  of  Common
                        Stock.

                  (v)   Phipps  beneficially  owns  730,850   shares   of Common
                        Stock.

            (B)  PERCENT OF CLASS.2

                  (i)   SR IV and SRB - 5.7%.

                  (ii)  Bayless - 6.1%

                  (iii) Dow - 6.2%

                  (iv)  Jaggers - 6.0%

                  (v)   Phipps - 6.1%

- -----------------------------------
     1 Of the shares of Common  Stock  beneficially  owned by each of SR IV, SRB
IV, Bayless,  Jaggers, Dow and Phipps,  658,113 shares are owned of record by SR
IV  and  24,421  shares   are  owned   of  record  by  Legomer  Investors,  Inc.
("Legomer").  SR IV is the  holder of a majority  of the issued and  outstanding
capital stock of Legomer and Dow is the President and a director of Legomer.

     2 According to the most recently  available  filing with the Securities and
Exchange Commission in which such number is required to be indicated.



                                  Page 9 of 13

<PAGE>


            (C)  POWER  TO  VOTE  OR  DIRECT  THE VOTE AND DISPOSE OR DIRECT THE
DISPOSITION OF SECURITIES.

                  (i)(a)   Each  of SR IV and SRB IV has  sole  power to vote or
                           dispose  or  to  direct  the  vote  or disposition of
                           658,113 shares of Common Stock.

                     (b)   Each of SR IV and SRB IV  has  shared  power  to vote
                           or dispose or to direct the vote  or  disposition  of
                           24,421 shares of Common Stock.

                  (ii)(a)  Bayless  has sole   power  to vote or  dispose  or to
                           direct the vote or disposition of  50,611  shares  of
                           Common Stock.

                      (b)  Bayless has shared power  to  vote or  dispose  or to
                           direct the vote or disposition of  682,534  shares of
                           Common Stock.

                  (iii)(a) Dow has sole  power to vote or  dispose  or to direct
                           the vote or disposition of  6,000  shares  of  Common
                           Stock.

                     (b)   Dow has shared power to vote or  dispose or to direct
                           the vote or disposition of 740,848  shares  of Common
                           Stock.

                  (iv)(a)  Jaggers has  sole  power  to  vote  or  dispose or to
                           direct  the vote or  disposition  of 37,693 shares of
                           Common Stock.

                      (b)  Jaggers has  shared  power to vote to dispose  or  to
                           direct  the  vote or disposition of 682,534 shares of
                           Common Stock.

                  (v)(a)   Phipps  has  sole  power  to  vote  or  dispose or to
                           direct the vote or disposition of  44,066  shares  of
                           Common Stock.

                       (b) Phipps  has  shared  power to vote or  dispose  or to
                           direct  the vote or  disposition  of  686,784  shares
                           of Common Stock.


                                 Page 10 of 13
<PAGE>


ITEM 5.     OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

            If this statement is being  filed to report  the fact that as of the
            date  hereof  the reporting  person  has ceased to be the beneficial
            owner of more than  five  percent  of the class of securities, check
            the following [ ]

ITEM 6.     OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

            Not Applicable.

ITEM 7.     IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY  WHICH  ACQUIRED
            THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.

            Not applicable.

ITEM 8.     IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

            Not applicable.

ITEM 9.     NOTICE OF DISSOLUTION OF GROUP.

            Not applicable.

ITEM 10.    CERTIFICATION.

            Not applicable.

                                 Page 11 of 13
<PAGE>


                        SIGNATURES/SIGNED IN COUNTERPART

            After reasonable inquiry and to the best knowledge and belief of the
undersigned,  the  undersigned  certify that the  information  set forth in this
statement is true, complete and correct.

                                    SEVIN ROSEN FUND IV L.P.

                                    By: SRB Associates IV L.P.,
                                      General Partner


Dated:  February 13, 1998          By:/s/ John Jaggers
                                      ------------------------------------------
                                      John V. Jaggers, a General Partner


                                    SRB ASSOCIATES IV L.P.


Dated:  February 13, 1998           By:/s/ John Jaggers
                                       -----------------------------------------
                                       John V. Jaggers, a General Partner


Dated:  February 13, 1998             /s/ Jon W. Bayless
                                      ------------------------------------------
                                      Jon W. Bayless


Dated:  February 13, 1998             /s/ John Jaggers, Attorney-in-fact
                                      ------------------------------------------
                                       Stephen M. Dow


Dated:  February 13, 1998             /s/ John Jaggers
                                      ------------------------------------------
                                       John V. Jaggers


Dated:  February 13, 1998             /s/ John Jaggers, Attorney-in-fact
                                      ------------------------------------------
                                       Charles H. Phipps


                                 Page 12 of 13
<PAGE>


                                  EXHIBIT INDEX

      EXHIBIT

1.          Joint Filing Agreement.



















                                 Page 13 of 13



                                    EXHIBIT 1

                  THIS DOCUMENT HAS BEEN SIGNED IN COUNTERPART

                             JOINT FILING AGREEMENT


            In accordance  with Rule 13d-1(f) under the Securities  Exchange Act
of 1934,  the persons named below agree to the joint filing on behalf of each of
them of a Statement on Schedule 13G (including  amendments thereto) with respect
to the common stock of ArQule,  Inc.,  and further  agree that this Joint Filing
Agreement be included as an exhibit to such joint filings.  In evidence  thereof
each of the undersigned, being duly authorized, hereby execute this Agreement on
the date set forth opposite its or his name.

                                    SEVIN ROSEN FUND IV L.P.

                                    By: SRB Associates IV L.P.,
                                      General Partner


Dated:  February 13, 1998          By:/s/ John Jaggers
                                      ------------------------------------------
                                      John V. Jaggers, a General Partner


                                    SRB ASSOCIATES IV L.P.


Dated:  February 13, 1998           By:/s/ John Jaggers
                                       -----------------------------------------
                                       John V. Jaggers, a General Partner


Dated:  February 13, 1998             /s/ Jon W. Bayless
                                      ------------------------------------------
                                      Jon W. Bayless


Dated:  February 13, 1998             /s/ John Jaggers, Attorney-in-fact
                                      ------------------------------------------
                                       Stephen M. Dow


Dated:  February 13, 1998             /s/ John Jaggers
                                      ------------------------------------------
                                       John V. Jaggers


Dated:  February 13, 1998             /s/ John Jaggers, Attorney-in-fact
                                      ------------------------------------------
                                       Charles H. Phipps


                                  Page 1 of 1




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