SEVIN ROSEN FUND IV LP
SC 13G/A, 1999-02-16
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<PAGE>
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  ------------

                                  SCHEDULE 13G
                                 (RULE 13d-102)

                           INFORMATION TO BE INCLUDED
                         IN STATEMENTS FILED PURSUANT TO
                   RULES 13D-1(b), (c) AND (d) AND AMENDMENTS
                       THERETO FILED PURSUANT TO 13d-2(b)

                               (AMENDMENT NO. 2)*

                                  ARQULE, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                                     COMMON
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   042 69E 107
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

              -----------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

                  Check the  appropriate  box to designate  the rule pursuant to
which this Schedule is filed:

                  |_|      Rule 13d-1(b)

                  |_|      Rule 13d-1(c)

                  |_|      Rule 13d-1(d)

                  *The  remainder  of this  cover page shall be filled out for a
reporting person's initial filing on this form with respect to the subject class
of securities,  and for any subsequent  amendment  containing  information which
would alter the disclosures provided in a prior cover page.

                  The  information  required in the remainder of this cover page
shall  not be  deemed  to be  "filed"  for  the  purpose  of  Section  18 of the
Securities  Exchange Act of 1934 or otherwise subject to the liabilities of that
section  of the Act but  shall be  subject  to all other  provisions  of the Act
(however, SEE the NOTES).


<PAGE>



1         NAMES OF REPORTING PERSONS
          I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

          Sevin Rosen Fund IV L.P.

2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  [   ]
                                                                    (b)  [   ]


3          SEC USE ONLY


4          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware

                             5     SOLE VOTING POWER
  NUMBER OF SHARES                 658,113
 BENEFICIALLY OWNED                
 BY EACH REPORTING           6     SHARED VOTING POWER
   PERSON WITH                     -0-

                             7     SOLE DISPOSITIVE POWER
                                   658,113

                             8     SHARED DISPOSITIVE POWER
                                   -0-

9         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          658,113

10        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
          CERTAIN SHARES*                                               [  ]

11        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

          5.4%

12        TYPE OF REPORTING PERSON*

          PN


                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                                       2
<PAGE>



1         NAMES OF REPORTING PERSONS
          I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

          SRB Associates IV L.P.

2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*      (a)  [   ]
                                                                 (b)  [   ]

3         SEC USE ONLY


4         CITIZENSHIP OR PLACE OF ORGANIZATION

          Delaware

                              5       SOLE VOTING POWER
  NUMBER OF SHARES                    658,113
 BENEFICIALLY OWNED                   
 BY EACH REPORTING            6       SHARED VOTING POWER
    PERSON WITH                       -0-

                              7       SOLE DISPOSITIVE POWER
                                      658,113

                              8       SHARED DISPOSITIVE POWER
                                      -0-
9         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          658,113

10        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
          CERTAIN SHARES*                                          [  ]

11        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

          5.4%

12        TYPE OF REPORTING PERSON*

          PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                                       3
<PAGE>



1         NAMES OF REPORTING PERSONS
          I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

          Jon W. Bayless

2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a)  [   ]
                                                                    (b)  [   ]

3         SEC USE ONLY

4         CITIZENSHIP OR PLACE OF ORGANIZATION

          U.S.

                              5   NUMBER OF SHARES
 SOLE VOTING POWER                50,611
 BENEFICIALLY OWNED                    
 BY EACH REPORTING            6   SHARED VOTING POWER
  PERSON WITH                     658,113

                              7   SOLE DISPOSITIVE POWER
                                  50,611

                              8   SHARED DISPOSITIVE POWER
                                  658,113

9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        708,724

10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
        CERTAIN SHARES*                                                [  ]

11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
        5.8%

12      TYPE OF REPORTING PERSON*

        IN


                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                                       4
<PAGE>



1         NAMES OF REPORTING PERSONS
          I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

          Stephen M. Dow

2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a)  [   ]
                                                                    (b)  [   ]


3         SEC USE ONLY


4         CITIZENSHIP OR PLACE OF ORGANIZATION

          U.S.

                             5    SOLE VOTING POWER
  NUMBER OF SHARES                14,500
BENEFICIALLY OWNED
 BY EACH REPORTING           6    SHARED VOTING POWER
   PERSON WITH                    716,427

                             7    SOLE DISPOSITIVE POWER
                                  14,500

                             8    SHARED DISPOSITIVE POWER
                                  716,427
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           730,927

10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
           CERTAIN SHARES*                                    [  ]

11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
           6.0%

12         TYPE OF REPORTING PERSON*

           IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                       5

<PAGE>



1         NAMES OF REPORTING PERSONS
          I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

          John V. Jaggers

2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  [   ]
                                                                   (b)  [   ]


3         SEC USE ONLY

4         CITIZENSHIP OR PLACE OF ORGANIZATION

          U.S.

                             5     SOLE VOTING POWER
  NUMBER OF SHARES                 37,693
 BENEFICIALLY OWNED                
 BY EACH REPORTING           6     SHARED VOTING POWER
   PERSON WITH                     658,113

                             7     SOLE DISPOSITIVE POWER
                                   37,693

                             8     SHARED DISPOSITIVE POWER
                                   658,113

9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       695,806

10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
       CERTAIN SHARES*                                             [  ]

11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

       5.7%

12     TYPE OF REPORTING PERSON*

       IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                                       6
<PAGE>




1         NAMES OF REPORTING PERSONS
          I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

          Charles H. Phipps

2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*       (a)  [   ]
                                                                  (b)  [   ]

3         SEC USE ONLY

4         CITIZENSHIP OR PLACE OF ORGANIZATION

          U.S.
                             5     SOLE VOTING POWER
  NUMBER OF SHARES                 44,066
 BENEFICIALLY OWNED         
 BY EACH REPORTING           6     SHARED VOTING POWER
   PERSON WITH                     662,363
               
                             7     SOLE DISPOSITIVE POWER
                                   44,066
                             
                             8     SHARED DISPOSITIVE POWER
                                   662,363

9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
      706,429

10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
      CERTAIN SHARES*                                         [  ]


11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
      5.8%

12    TYPE OF REPORTING PERSON*

      IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


                                       7

<PAGE>




1         NAMES OF REPORTING PERSONS
          I.R.S. IDENTIFICATIONS NOS. OF ABOVE PERSONS

          Jennifer Gill Roberts

2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*       (a)  [   ]
                                                                  (b)  [   ]


3         SEC USE ONLY

4         CITIZENSHIP OR PLACE OF ORGANIZATION
          U.S.

                             5    SOLE VOTING POWER
 NUMBER OF SHARES                 0
BENEFICIALLY OWNED
 BY EACH REPORTING           6    SHARED VOTING POWER
   PERSON WITH                    658,113

                             7    SOLE DISPOSITIVE POWER
                                  0

                             8    SHARED DISPOSITIVE POWER
                                  658,113

9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
      658,113

10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
      CERTAIN SHARES*                                                [  ]

11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
      5.4%

12    TYPE OF REPORTING PERSON*

      IN


                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                                       8


<PAGE>


ITEM 1.
                  (A)  NAME OF ISSUER.

                  ArQule, Inc., a Delaware corporation (the "Issuer").

                  (B)  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES.

                  The Issuer's principal executive offices  are  located  at 200
Boston Avenue, Medford, Massachusetts  02155.

ITEM 2.
                  (A) NAMES OF PERSONS FILING.

                  This  statement is filed by the following  persons:  (i) Sevin
Rosen Fund IV L.P. ("SR IV"); (ii) SRB Associates IV L.P. ("SRB IV");  (iii) Jon
W.  Bayless  ("Bayless");  (iv)  Stephen  M. Dow  ("Dow");  (v) John V.  Jaggers
("Jaggers");  (vi) Charles H. Phipps ("Phipps"); and (vii) Jennifer Gill Roberts
("Roberts").  SRB IV is the general  partner of SR IV.  Bayless,  Dow,  Jaggers,
Phipps and Roberts are the general partners of SRB IV.

                  (B)  ADDRESS OF PRINCIPAL BUSINESS OFFICE.

                  The  principal  business  office  of  each  of SR IV,  SRB IV,
Bayless, Jaggers, and Phipps is Two Galleria Tower, 13455 Noel Road, Suite 1670,
Dallas,  Texas 75240.  The principal  business  office of Dow and Roberts is 169
University Avenue, Palo Alto, California 94301.

                  (C)  CITIZENSHIP.

                  SR  IV  and  SRB  IV  are  each Delaware limited partnerships.
Bayless, Dow, Jaggers, Phipps and Roberts are each U.S. citizens.

                  (D) TITLE OF CLASS OF SECURITIES.

                  This  statement  relates to shares of Common Stock,  par value
$.01 per share (the "Common Stock"),  of the Issuer.


                                       9
<PAGE>


                  (E) CUSIP NUMBER.

                  042 69E 107

ITEM 3.
                  This statement is not being filed pursuant to Rule 13d-1(b) or
                  13d-2(b).

ITEM 4.           OWNERSHIP.(1)

                  (A)  AMOUNT BENEFICIALLY OWNED.

                         (i)   Each of SR IV,  SRB IV and  Roberts  beneficially
                               owns  658,113  shares of Common  Stock.

                         (ii)  Bayless  beneficially  owns  708,724  shares  of
                               Common  Stock.

                         (iii) Dow beneficially  owns 722,427 shares of Common
                               Stock.

                         (iv)  Jaggers  beneficially owns 695,806 shares
                               of Common Stock.

                         (v)   Phipps beneficially owns 706,429
                               shares of Common Stock.

                  (B)  PERCENT  OF  CLASS.(2)

                         (i)   SR IV and SRB - 5.4%.

                         (ii)  Bayless - 5.8%

                         (iii) Dow - 5.9%

                         (iv)  Jaggers - 5.7%

                         (v) Phipps - 5.8%

                         (vi) Roberts - 5.4%

- --------
   (1) Of the shares of Common  Stock  beneficially  owned by each of SR IV, SRB
IV,  Bayless,  Jaggers,  Dow,  Phipps and Roberts,  658,113  shares are owned of
record by SR IV.

  (2) According to the most recently  available  filing with the Securities and
Exchange Commission in which such number is required to be indicated.

                                       10
<PAGE>


                  (C) POWER TO VOTE OR DIRECT THE VOTE AND DISPOSE OR DIRECT THE
DISPOSITION OF SECURITIES.

                           (i)(a)   Each of SR IV and SRB IV has sole  power  to
                                    to vote or  dispose or to direct the vote or
                                    disposition  of  658,113  shares  of  Common
                                    Stock.

                              (b)   Each  of SR IV and SRB IV has  shared  power
                                    to vote or  dispose or to direct the vote or
                                    disposition of no shares of Common Stock.

                           (ii)(a)  Bayless  has  sole  power  to  vote  or
                                    dispose or to direct the vote or disposition
                                    of 50,611 shares of Common Stock.

                               (b)  Bayless has shared  power to vote or dispose
                                    or to  direct  the  vote or  disposition  of
                                    658,113 shares of Common Stock.

                           (iii)(a) Dow has sole  power to vote or dispose or to
                                    direct  the vote or  disposition  of  14,500
                                    shares of Common Stock.

                                (b) Dow has shared power to  vote  or dispose or
                                    to direct the vote or disposition of 716,427
                                    shares of Common Stock.

                           (iv) (a) Jaggers  has  sole  power  to  vote  or
                                    dispose or to direct the vote or disposition
                                    of 37,693 shares of Common Stock.

                                 (b)Jaggers has shared  power to vote to dispose
                                    or to  direct  the  vote or  disposition  of
                                    658,113 shares of Common Stock.

                           (v)(a)   Phipps has  sole power to vote or dispose or
                                    to  direct the vote or disposition of 44,066
                                    shares of Common Stock.

                                (b) Phipps has  shared  power to vote or dispose
                                    or to  direct  the  vote or  disposition  of
                                    662,363 shares of Common Stock.

                           (v)(a)   Roberts has sole power to vote or dispose or
                                    to  direct  the  vote or  disposition  of no
                                    shares of Common Stock.

                                (b) Roberts has shared  power to vote or dispose
                                    or to  direct  the  vote or  disposition  of
                                    658,113 shares of Common Stock.



<PAGE>

ITEM 5.           OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

                  If this statement is being filed to report the fact that as of
                  the date  hereof  the  reporting  person  has ceased to be the
                  beneficial  owner of more  than five  percent  of the class of
                  securities, check the following [ ]

ITEM 6.           OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER
                  PERSON.

                  Not Applicable.

ITEM 7.           IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
                  ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT
                  HOLDING COMPANY.

                  Not applicable.

ITEM 8.           IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

                  Not applicable.

ITEM 9.           NOTICE OF DISSOLUTION OF GROUP.

                  Not applicable.

ITEM 10.          CERTIFICATION.

                  Not applicable.


<PAGE>



                        SIGNATURES/SIGNED IN COUNTERPART


                  After reasonable  inquiry and to the best knowledge and belief
of the  undersigned,  the undersigned  certify that the information set forth in
this statement is true, complete and correct.

 
                                  SEVIN ROSEN FUND IV L.P.
                                  By: SRB Associates IV L.P.,
                                      General Partner

Dated: February 16, 1999          By: /S/ JOHN V. JAGGERS
                                      -----------------------------------
                                      John V. Jaggers,  a General Partner

                                   SRB ASSOCIATES IV L.P.

Dated: February 16, 1999           By: /S/ JOHN V. JAGGERS
                                      ------------------------------------
                                      John V. Jaggers, a General Partner


Dated: February 16, 1999              /S/ JOHN V. JAGGERS
                                      -------------------------------------
                                      Jon W. Bayless, by John V. Jaggers,
                                      Attorney-in-Fact

Dated: February 16, 1999              /S/ JOHN V. JAGGERS
                                      -------------------------------------
                                      Stephen M. Dow, by John V. Jaggers,
                                      Attorney-in-Fact


Dated: February 16, 1999              /S/ JOHN V. JAGGERS
                                      --------------------------------------
                                      John V. Jaggers


Dated: February 16, 1999                /S/ JOHN V. JAGGERS
                                      --------------------------------------
                                      Charles H. Phipps, by John V. Jaggers,
                                      Attorney-in-Fact


Dated: February 16, 1999              /S/ JOHN V. JAGGERS
                                      ---------------------------------------
                                      Jennifer Gill Roberts, by John V. Jaggers,
                                      Attorney-in-Fact




<PAGE>





                                  EXHIBIT INDEX
EXHIBIT

99.1              Joint Filing Agreement.



<PAGE>



                  THIS DOCUMENT HAS BEEN SIGNED IN COUNTERPART

                             JOINT FILING AGREEMENT

                  In accordance with Rule 13d-1(f) under the Securities Exchange
Act of 1934, the persons named below agree to the joint filing on behalf of each
of them of a Statement  on Schedule  13G  (including  amendments  thereto)  with
respect to the common stock of ArQule,  Inc.,  and further agree that this Joint
Filing  Agreement be included as an exhibit to such joint  filings.  In evidence
thereof each of the  undersigned,  being duly  authorized,  hereby  execute this
Agreement on the date set forth opposite its or his name.

                                  SEVIN ROSEN FUND IV L.P.
                                  By: SRB Associates IV L.P.,
                                      General Partner

Dated: February 16, 1999          By: /S/ JOHN V. JAGGERS
                                      -----------------------------------
                                      John V. Jaggers,  a General Partner

                                   SRB ASSOCIATES IV L.P.

Dated: February 16, 1999           By: /S/ JOHN V. JAGGERS
                                      ------------------------------------
                                      John V. Jaggers, a General Partner


Dated: February 16, 1999              /S/ JOHN V. JAGGERS
                                      -------------------------------------
                                      Jon W. Bayless, by John V. Jaggers,
                                      Attorney-in-Fact

Dated: February 16, 1999              /S/ JOHN V. JAGGERS
                                      -------------------------------------
                                      Stephen M. Dow, by John V. Jaggers,
                                      Attorney-in-Fact


Dated: February 16, 1999              /S/ JOHN V. JAGGERS
                                      --------------------------------------
                                      John V. Jaggers


Dated: February 16, 19                /S/ JOHN V. JAGGERS
                                      --------------------------------------
                                      Charles H. Phipps, by John V. Jaggers,
                                      Attorney-in-Fact


Dated: February 16, 1999              /S/ JOHN V. JAGGERS
                                      ---------------------------------------
                                      Jennifer Gill Roberts, by John V. Jaggers,
                                      Attorney-in-Fact





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