BIOWHITTAKER INC
SC 13D/A, 1997-08-26
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                     SECURITIES AND EXCHANGE COMMISSION
                           WASHINGTON, D.C. 20549
                     ___________________________________
                                SCHEDULE 13D
                               (RULE 13D-101)

                  UNDER THE SECURITIES EXCHANGE ACT OF 1934
                             (Amendment No. 4){1}

                              BIOWHITTAKER, INC.
               ----------------------------------------------------          
                              (Name of issuer)

                    COMMON STOCK, PAR VALUE $0.01 PER SHARE
               -----------------------------------------------------
                       (Title of class of securities)

                              09066T 10 8
               -----------------------------------------------------
                            (CUSIP number)

                         RICHARD T. MCDERMOTT, ESQ.
                             ROGERS & WELLS
                            200 PARK AVENUE
                         NEW YORK, NEW YORK 10166
                             (212) 878-8000
             -------------------------------------------------------- 
                (Name, address and telephone number of person
              authorized to receive notices and communications)

                           AUGUST 22, 1997
           ---------------------------------------------------------  
            (Date of event which requires filing of this statement)

               If  the  filing  person has previously filed a statement  on
     Schedule 13G to report the acquisition  which  is  the subject of this
     Schedule 13D, and is filing this schedule because of  Rule 13d-1(b)(3)
     or (4), check the following box  <square>.


               NOTE.  Six copies of this statement, including all exhibits,
     should  be  filed with the Commission.  SEE Rule 13d-1 (a)  for  other
     parties to whom copies are to be sent.

                       (Continued on following pages)

                             (Page 1 of 9 Pages)
                       Exhibit A begins after Page 9.





__________________________
     {1} The remainder  of  this cover page shall be filled out for a reporting
person's initial filing on this  form  with  respect  to  the  subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

     The information required on the remainder of this cover page  shall not be
deemed  to be "filed" for the purpose of Section 18 of the Securities  Exchange
Act of 1934  or otherwise subject to the liabilities of that section of the Act
but shall be subject  to  all  other  provisions  of  the Act (however, SEE the
NOTES.)

                         PAGE 1 OF 9 PAGES

PAGE
<PAGE>
                                             SCHEDULE 13D


CUSIP NO. 09066T 10 8                                         PAGE 2 OF 9 PAGES


<TABLE>
<CAPTION>
  <S>     <C>                <C>    <C>
  
   1      NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                ANASCO GMBH
 
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                          (a) <square>
                                                                                                    (b) <square>
   3      SEC USE ONLY

   4      SOURCE OF FUNDS*

   5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(C) OR 2(E)        <square>

   6      CITIZENSHIP OR PLACE OF ORGANIZATION

               FEDERAL REPUBLIC OF GERMANY
   
                             7      SOLE VOTING POWER
  
                                        2,097,043
           NUMBER OF
            SHARES           8      SHARED VOTING POWER
         BENEFICIALLY
           OWNED BY                     NONE
             EACH
          REPORTING          9      SOLE DISPOSITIVE POWER
           PERSON
            WITH                        2,097,043


                            10      SHARED DISPOSITIVE POWER

                                        NONE

  11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                                  <square>

                 2,097,043

  12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                         <square>

  13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                 APPROXIMATELY 19.9%

  14      TYPE OF REPORTING PERSON*

                 CO
</TABLE>




                   *SEE INSTRUCTIONS BEFORE FILLING OUT!

          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES  TO ITEMS 1-7
       (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.

                         PAGE 2 OF 9 PAGES

<PAGE>

          This  Amendment  No.  4  ("Amendment  No. 4") to the Statement on
Schedule 13D dated November 7, 1991 (the "Schedule 13D") is filed by Anasco
GmbH, a limited liability company duly incorporated  in Germany ("Anasco"),
in   connection   with  its  beneficial  ownership  of  Common   Stock   of
BioWhittaker, Inc.,  a  Delaware  corporation.   Schedule 13D as previously
amended by Amendment No. 1, dated January 11, 1995,  Amendment No. 2, dated
May 22, 1995, and Amendment No. 3, dated May 16, 1997, is hereby amended as
set forth below.


ITEM 4.   PURPOSE OF TRANSACTION

          Item  4  of Schedule 13D is amended in its entirety  to  read  as
follows:

          Anasco  acquired  the  shares  of  Common  Stock  for  investment
purposes.  The acquisition  was  consummated pursuant to the Stock Purchase
Agreement, dated as of September 24,  1991,  by  and between the Issuer and
Anasco (the "Stock Purchase Agreement").

          Anasco's  acquisition  of  the  Common  Stock   was  effected  in
connection   with   a  Joint  Venture  and  Partnership  Agreement,   dated
October 31, 1991 (the "Joint Venture Agreement"), by and between Boehringer
Ingelheim Bioproducts, Inc., a Delaware corporation and affiliate of Anasco
("BI  Bioproducts"),  and  BioWhittaker  International,  Inc.,  a  Delaware
corporation and at that  time  a wholly-owned subsidiary of the Issuer ("BW
Int'l").  Pursuant to the Joint  Venture  Agreement,  the name of the joint
venture  formed  thereunder  was  "Boehringer  Ingelheim  BioWhittaker,"  a
Delaware  general  partnership  (the  "Partnership").  The Partnership  was
formed for the purpose of manufacturing  and  marketing certain products of
the  Issuer outside the United States.

          On May 5, 1995, Boehringer Ingelheim International GmbH, a German
limited  liability  company ("BII GmbH"), an affiliate of Anasco, purchased
all of the issued and  outstanding shares of capital stock of BW Int'l (the
"BW Int'l Stock") pursuant  to  a  stock purchase agreement dated April 30,
1995 (the "BW Int'l Stock Purchase Agreement").   Subsequently, the name of
BW  Int'l  was  changed to Boehringer Ingelheim Bioproducts  International,
Inc. ("BIBI, Inc.")  As a result of this purchase, BII GmbH became the 100%
owner of both general  partners  of  the  Partnership, and the Partnership,
accordingly, is  now  wholly  owned  by  an affiliate of Anasco.  The name
of the  Partnership  was  subsequently  changed  to  "Boehringer Ingelheim
Bioproducts." 

          In connection with an earlier public  announcement  by the Issuer
concerning  its  review  of  various strategic options and with a presently
pending  reassessment  of  the bioproducts  and  biosystems  businesses  of
companies within the Boehringer  Ingelheim  group,  initial steps have been
taken to determine whether there might be prospective purchasers of various
types  of  assets  related  to  the  group's  bioproducts  and   biosystems
businesses.   Depending  on the results of this reassessment, BII GmbH  may
determine to dispose of some  or all of such types of assets, including but
not limited to some or all of its equity interest in BIBI, Inc.

          After  the  close of business on  August  22,  1997,  the  Issuer
entered into an Agreement  and  Plan of Merger, dated August 22, 1997, with

                     PAGE 3 PF 9 PAGES
<PAGE>


Cambrex   Corporation,   a  Delaware  corporation,   and   BW   Acquisition
Corporation, a Delaware corporation  and wholly-owned subsidiary of Cambrex
Corporation (the "Merger Agreement"),  pursuant  to  which  BW  Acquisition
Corporation  would  be merged with and into the Issuer (the "Merger").   In
furtherance  of  the Merger,  Cambrex  Corporation  has  proposed  that  BW
Acquisition Corporation  make  an  offer  to  purchase  for cash all of the
issued and outstanding Common Stock and all associated rights  to  purchase
preferred stock (the "Offer").

          Cambrex Corporation required, as a condition to its entering into
the Merger Agreement and commencing the Offer, that Anasco enter into,  and
Anasco agreed to enter into, the Stockholders Agreement, dated as of August
22,  1997, by  and  among  Cambrex  Corporation, BW Acquisition Corporation
and Anasco (the  "Stockholders  Agreement").  Concurrently with the  Merger
Agreement,  the  Stockholders Agreement  was  executed  after  the close of
business on Friday, August 22,  1997, substantially in  the form of Exhibit
A of this Amendment No. 4.

          Pursuant  to  Section  2  of  the  Stockholders Agreement, Anasco
irrevocably  agreed  duly  to  tender  all of its shares  of  Common  Stock
pursuant to the terms of the Offer and not to withdraw such shares prior to
the expiration of the Offer.

          Pursuant to Section 3(a) of the  Stockholders  Agreement,  Anasco
agreed  that, during the time that the Stockholders Agreement is in effect,
at any meeting  of  the  stockholders  of the Issuer, however called, or in
connection  with any written consent of the  stockholders  of  the  Issuer,
Anasco shall vote (or cause to be voted ) all of its shares of Common Stock
(i) in favor of the Merger, the execution and delivery by the Issuer of the
Merger Agreement  and  the  approval  of  the terms thereof and each of the
other  actions contemplated by the Merger Agreement  and  the  Stockholders
Agreement and any actions required in furtherance thereof; (ii) against any
action or  agreement  that  would  result  in  a  breach  of  any covenant,
representation  or  warranty  or any other obligation or agreement  of  the
Issuer under the Merger Agreement, the Offer or the Stockholders Agreement;
and  (iii)  except  as  specifically   requested   in  writing  by  Cambrex
Corporation  in  advance,  against the following actions  (other  than  the
Merger and the transactions contemplated by the Merger Agreement):  (A) any
extraordinary corporate transaction,  such  as  a  merger, consolidation or
other business combination involving the Issuer or its  subsidiaries; (B) a
sale, lease or transfer of a material amount of assets of the Issuer or its
subsidiaries    or   a   reorganization,   recapitalization,   dissolution,
liquidation or winding up of the Issuer or any of its subsidiaries; (C) any
change in the majority  of  the  board  of directors of the Issuer; (D) any
material  change  in  the  present capitalization  of  the  Issuer  or  any
amendment  of the Issuer's certificate  of  incorporation;  (E)  any  other
material change  in  the  Issuer's corporate structure or business; and (F)
any other action which is intended  or  could  reasonably  be  expected  to
impede, interfere with, delay, postpone, discourage or materially adversely
affect the Merger, the transactions contemplated by the Merger Agreement or
the  Stockholders Agreement or the contemplated economic benefits of any of
the foregoing.   Anasco shall not enter into any agreement or understanding
with any Person (as  defined  in  the  Stockholders Agreement) prior to the
Termination Date (as defined in Section 9 of the Stockholders Agreement) to
vote in any manner inconsistent with clause  (i),  (ii)  or  (iii)  of  the
preceding sentence.

                     PAGE 4 OF 9 PAGES
<PAGE>




          Pursuant  to  Section  4 of the Stockholders Agreement, except in
accordance with the terms of the Stockholders  Agreement, Anasco covenanted
and agreed as follows:  Pursuant to Section 4(a) Anasco shall not, directly
or indirectly (including through advisors, agents or other intermediaries),
initiate, solicit, negotiate, encourage or provide confidential information
to  facilitate  any  proposal  or  offer by any Person (as defined  in  the
Stockholders Agreement) that constitutes or could reasonably be expected to
lead to an Acquisition Transaction (as  defined  in  the Merger Agreement);
provided,  however, that no provision of the Stockholders  Agreement  shall
prohibit or  in  any way restrict the right of Anasco and its affiliates to
initiate, solicit, negotiate, encourage or provide confidential information
to any party in connection  with  a  possible  sale or other disposition by
Anasco  or such affiliate of its interest in the  Partnership.   If  Anasco
receives  any  such  inquiry or proposal, then Anasco shall promptly inform
Cambrex Corporation of  the  material terms and conditions, if any, of such
inquiry or proposal and the identity  of  the  Person  (as  defined  in the
Stockholders  Agreement)  making  it.   Anasco  further agrees that it will
immediately  cease  and  cause  to be terminated any  existing  activities,
discussions or negotiations with  any  parties  conducted  theretofore with
respect  to  any  of  the  forgoing.   Nothing  in  Section  4(a)  of   the
Stockholders  Agreement  shall  restrict  or  limit the ability of Anasco's
designee on the board of directors of the Issuer to take or perform in such
capacity any of the actions or do any of the things the Issuer is permitted
to take or perform under Section 4.1(a) and 4.1(b) of the Merger Agreement.

          Pursuant  to  Section 4(b) of the Stockholders  Agreement  Anasco
shall not, directly or indirectly,  (i) except pursuant to the terms of the
Merger Agreement, the Offer and the Stockholders Agreement, offer for sale,
sell, transfer, tender, pledge, encumber,  assign  or  otherwise dispose of
(collectively,  "Disposition")  enforce  or  permit  the execution  of  the
provisions  of  any  agreement with the Issuer whereby the  Issuer  may  be
obligated to repurchase,  or enter into any other contract, option or other
arrangement or understanding  with  respect to, or otherwise consent to the
Disposition  of  any or all of Anasco's  shares  of  Common  Stock  or  any
interest therein;  except  as  contemplated  by the Stockholders Agreement,
grant any proxies or powers of attorney, deposit any shares of Common Stock
into a voting trust or enter into a voting agreement  with  respect  to any
shares  of  Common  Stock;  or  (iii)  take  any action that would make any
representation  or  warranty  of  Anasco  contained   in  the  Stockholders
Agreement untrue or incorrect or have the effect of preventing or disabling
Anasco from performing its obligations under the Stockholders Agreement.

          Pursuant  to Section 4(c) of the Stockholders  Agreement,  Anasco
waived any rights of appraisal or rights to dissent from the Merger that it
may have.

          Pursuant to  Section  5(a)  of the Stockholders Agreement, Anasco
granted to BW Acquisition Corporation an  irrevocable option  (the "Cambrex
Option")  to  purchase  Anasco's  shares of Common Stock, on the terms  and
subject to the conditions set forth in the Stockholders Agreement.  Section
5(b)  thereof provides that the Cambrex  Option  may  be  exercised  by  BW
Acquisition  Corporation,  as a whole and not in part, at any time and from
time to time from and after  any  time  when  the Merger Agreement has been
terminated in accordance with its terms and prior  to  the Termination Date
(as defined in Section 9 of the Stockholders Agreement), subject to certain
specified  conditions  set  forth  in  Section  5(f)  of  the  Stockholders

                     PAGE 5 OF 9 PAGES
<PAGE>



Agreement.   Section 5(e) of the Stockholders Agreement provides  that  the
purchase price  of Anasco's shares of Common Stock, upon the exercise by BW
Acquisition of the  Cambrex Option, shall be an amount equal to the product
of the Merger Consideration  (as  defined  in the Merger Agreement) and the
number of shares purchased pursuant to the exercise of the Cambrex Option.

          Under Section 7 of the Stockholders Agreement, Anasco agreed that
the Stockholders Agreement and the obligations  thereunder  shall attach to
Anasco's  shares of Common Stock and shall be binding upon any  Person  (as
defined in  the  Stockholders  Agreement)  to  which  legal  or  beneficial
ownership  of  such  shares  shall  pass,  whether  by  operation of law or
otherwise.   Pursuant  to  Section 8 of the Stockholders Agreement,  Anasco
agreed with, and covenanted to, Cambrex  Corporation,  among  other things,
that Anasco shall not request that the Issuer register the transfer  (book-
entry   or   otherwise)  of  any  certificate  or  uncertificated  interest
representing any  of  Anasco's shares of Common Stock, unless such transfer
is made in compliance with the Offer or the Stockholders Agreement.

          Section  9  of  the  Stockholders  Agreement  provides  that  the
Stockholders Agreement  shall  terminate  upon  the  earlier  of (a) twelve
months from the date thereof or (b) the Effective Time (as defined  in  the
Merger  Agreement);  provided, however, that if the Issuer is not in breach
of its obligations under  the  Merger Agreement and Anasco is not in breach
of  its  obligations  under the Stockholders  Agreement,  the  Stockholders
Agreement shall terminate upon termination of the Merger Agreement pursuant
to  certain specified provisions  set  forth  therein.   The  date  of  the
termination   of   the   Stockholders  Agreement  is  referred  to  in  the
Stockholders Agreement as the "Termination Date."

          In addition, certain representations and warranties of Anasco are
set forth in Section 1 of  the  Stockholders  Agreement.   Other  terms and
conditions are also included in the Stockholders Agreement.

          Under  the terms of the Stock Purchase Agreement, Anasco and  its
affiliates may not  sell  5%  or  more  of  the Issuer's outstanding voting
securities  in  any transaction or series of related  transactions  without
first giving the  Issuer  an  opportunity  to purchase such securities at a
price equal to the price offered by the prospective  purchaser.  Anasco has
been informed by the Issuer that its board of directors  has voted to waive
(i) certain rights of first refusal granted to the Issuer  pursuant  to the
Stock  Purchase  Agreement  to purchase shares of Common Stock from Anasco;
(ii)  certain  prohibitions  on  Anasco  pursuant  to  the  Stock  Purchase
Agreement under which Anasco is  not  permitted  to engage in, encourage or
initiate  certain  acquisition, solicitation, and proxy  activities  or  to
grant  certain  proxies  or  enter  into  certain  voting  arrangements  or
agreements, and (iii)  any  other  rights  of  Anasco pursuant to the Stock
Purchase Agreement to the extent that, absent such waiver, the execution of
the  Stockholder Agreement by Anasco or consummation  of  the  transactions
contemplated thereby would constitute a violation or breach of any covenant
of the Stock Purchase Agreement; provided however, that upon the expiration
of the  term  of  the Stockholder Agreement such rights of first refusal as
granted by the Stock Purchase Agreement, such prohibitions set forth in the
Stock Purchase Agreement,  and  such other rights of the Issuer pursuant to
the Stock Purchase Agreement will  continue  in effect as if no such waiver
had been granted.

                     PAGE 6 OF 9 PAGES
<PAGE>



          No assurances can be given that the  Offer  will  be  made  by BW
Acquisition  Corporation,  or  if it is made that it will be completed.  If
the Merger has not been consummated  and  the  Merger  Agreement  has  been
terminated  in  accordance with its terms and prior to the Termination Date
(as defined in Section  9 of the Stockholders Agreement), no assurances can
be given that BW Acquisition Corporation will exercise the Cambrex Option.

          Except as indicated  in  this Item 4, Anasco has no other present
plans or proposals with respect to the Issuer.  In the event that the Offer
is not completed or if  the Merger Agreement is terminated  and BW Acquisi-
tion Corporation does not exercise the Cambrex Option, upon  the  basis  of
Anasco's continuing  review  of  the  Issuer's  business and its investment
position, Anasco may develop other plans or proposals  with  respect to the
Issuer.

          Under  the  Stock  Purchase  Agreement, Anasco and its affiliates
were required to limit their beneficial ownership in shares of Common Stock
of  the  Issuer  to  not  more  than  19.9%  prior  to  December  2,  1993.
Furthermore, prior to December 2, 1993, Anasco  and its affiliates were not
permitted  to  sell  or  otherwise  to  transfer  any of  their  beneficial
ownership in shares of Common Stock of the Issuer other  than to affiliates
which  agreed  to  abide  by  such  restrictions.  As of the date  of  this
Amendment No. 4, these restrictions are no longer in effect.

          Any disposition by BII GmbH  of assets related to the Boehringer
Ingelheim group's bioproducts and biosystems businesses, including but not
limited to some or all of  its equity interest in BIBI, Inc., would depend
on  the  ultimate  results of  the  reassessment  within  the  Boehringer
Ingelheim  group  and would be subject to the applicable purchase price of
such  assets  and/or  the capital stock of BIBI, Inc., the availability of
prospective purchasers and  subsequent developments  affecting such assets
and/or BIBI,  Inc., the respective businesses and products of BIBI,  Inc.,
the bioproducts  and biosystems industry  as a whole, other investment and
business  opportunities available to  BII   GmbH,   general  stock  market
and  economic  conditions,  tax considerations, and other factors.

          Any disposition  of capital stock of BIBI, Inc. by BII GmbH would
be subject to the terms and  conditions  of  the  BW  Int'l  Stock Purchase
Agreement.  [CHANGE OF CONTROL CLAUSE?]  Among other things, the  BW  Int'l
Stock Purchase Agreement provides for an option (the "BW Int'l Option")  in
favor  of  the  Issuer  to repurchase the BW Int'l Stock, such option being
exercisable, subject to certain  conditions, on or prior to April 30, 2000.
Moreover,  under the BW Int'l Stock  Purchase  Agreement,  the  Issuer  was
granted certain  rights  reserved  in  the  Joint  Venture Agreement to the
partners  in the Partnership (the "Restrictive Rights"),  such  Restrictive
Rights to be in effect during the exercise period of the BW Int'l Option.  
BII GmbH has the right, however, to terminate the BW Int'l Option following
a change of control of the Issuer.

          As  the  result of the agreements set forth in the BW Int'l Stock
Purchase Agreement,  references  throughout  this Schedule 13D to the Joint
Venture Agreement are deemed to be amended to  reflect  the purchase by BII
GmbH  of 100% of the BW Int'l Stock, the grant of the BW Int'l  Option  and
the Restrictive Rights.

          Other  than  as described above in this Item 4, as of the date of
this Amendment No. 4, Anasco  and its affiliates have no plans or proposals
which relate to or would result in:

                             PAGE 7 OF 9 PAGES 
<PAGE>



     (a)  The acquisition by any  person  of  additional  securities of the
Issuer, or the disposition of securities of the Issuer;
     (b)  An  extraordinary  corporate  transaction,  such  as  a   merger,
reorganization   or  liquidation,  involving  the  Issuer  or  any  of  its
subsidiaries;
     (c)  A sale or  transfer  of a material amount of assets of the Issuer
or of any of its subsidiaries;
     (d)  Any change in the present board of directors or management of the
Issuer, including any plans or proposals  to  change  the number or term of
directors or to fill any existing vacancies on the board;
     (e)  Any  material  change in the present capitalization  or  dividend
policy of the Issuer;
     (f)  Any other material  change  in the Issuer's business or corporate
structure;
     (g)  Changes   in  the  Issuer's  charter,   bylaws   or   instruments
corresponding thereto  or other actions which may impede the acquisition of
control of the Issuer by any person;
     (h)  Causing a class  of securities of the Issuer to be de-listed from
a national securities exchange or to cease to be authorized to be quoted in
an  inter-dealer  quotation system  of  a  registered  national  securities
association;
     (i)  A class of  equity securities of the Issuer becoming eligible for
termination of registration  pursuant to Section 12(g)(4) of the Securities
Exchange Act of 1934, as amended; or
     (j)  Any action similar to any of those enumerated above.


ITEM 6    CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR
          RELATIONSHIP WITH RESPECT TO SECURITIES OF THE ISSUER

          Item  6  of Schedule 13D  is  amended  by  the  addition  of  the
following paragraph:

          Cambrex Corporation required, as a condition to its entering into
the Merger Agreement  and commencing the Offer, that Anasco enter into, and
Anasco  agreed to enter  into,  the  Stockholders  Agreement,  pursuant  to
Section 2  of  which  Anasco  irrevocably  agreed duly to tender all of its
shares  of Common Stock pursuant to the terms  of  the  Offer  and  not  to
withdraw  such  shares  prior to the expiration of the Offer.  In addition,
pursuant to Section 5(a) of  the  Stockholders Agreement, Anasco granted to
BW  Acquisition Corporation  an irrevocable  option  to  purchase  Anasco's
shares of Common Stock on the terms and subject to the conditions set forth
in Section  5  of  the Stockholders Agreement.  The terms and conditions of
the Stockholders Agreement  are  more  fully  described  in  Item 4 of this
Amendment No. 4.  Concurrently  with the Merger Agreement, the Stockholders
Agreement was executed  after the close  of business  on Friday, August 22,
1997, substantially in the form of Exhibit A of this Amendment No. 4.


ITEM 7    MATERIALS TO BE FILED AS EXHIBITS

Exhibit  A:  Form  of  Stockholders Agreement, dated as of August 22, 1997,
          among Cambrex  Corporation, BW Acquisition Corporation and Anasco
          GmbH.

                     PAGE 8 OF 9 PAGES
<PAGE>
                         


                             SIGNATURE

          After reasonable  inquiry  and  to  the  best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.



                              Dated:  August 25, 1997




                              ANASCO GMBH



                              By: /S/ GERHARD HUBER
                                 ______________________
                              Name:  Gerhard Huber
                              Title: Authorized Signatory



                              By: /S/ JUERGEN ROEMHILD
                                 ______________________
                              Name:  Juergen Roemhild
                              Title: Authorized Signatory


<PAGE>


                                     EXHIBIT A

          [FORM OF STOCKHOLDERS AGREEMENT, DATED AS OF AUGUST 22, 1997, AMONG
           CAMBREX CORPORATION, BW ACQUISITION CORPORATION AND ANASCO GMBH]

                              STOCKHOLDERS AGREEMENT

          STOCKHOLDERS AGREEMENT dated as of August 22, 1997 among Cambrex
Corporation, a Delaware corporation ("Parent"), BW Acquisition Corporation,
a Delaware corporation ("Purchaser") and ANASCO GmbH, a German limited
liability company ("Stockholder").


          WHEREAS, concurrently herewith Parent, the Purchaser, and
BioWhittaker, Inc., a Delaware corporation (the "Company"), are entering
into an Agreement and Plan of Merger of even date herewith (as such
agreement may be amended from time to time, the "Merger Agreement";
capitalized terms used but not otherwise defined herein shall have the
respective meanings ascribed to them in the Merger Agreement) pursuant to
which the Purchaser will be merged with and into the Company (the
"Merger"); and

          WHEREAS, in furtherance thereof, the Parent proposes that the
Purchaser make an offer (the "Offer") to purchase for cash all of the
issued and outstanding shares of common stock of the Company, and all
associated rights to purchase preferred stock, at a price of $11.625 per
share net to the seller;

          WHEREAS, Parent has required, as a condition to its entering into
the Merger Agreement and commencing the Offer, that Stockholder enter into,
and Stockholder has agreed to enter into, this Agreement.

          NOW, THEREFORE, to satisfy this condition and in consideration of
Parent's entering into the Merger Agreement and causing the Offer to be
commenced, respectively, and in consideration of the premises and the
representations, warranties and covenants contained herein, the parties
agree as follows:

                                       Exh. A-1
<PAGE>

          1.   REPRESENTATIONS AND WARRANTIES OF STOCKHOLDER.  Stockholder
hereby represents and warrants to Parent as follows:

          (a)  OWNERSHIP OF SHARES. (i) Stockholder is the record holder
     and beneficial owner of the number of shares of the common stock of
     the Company, par value $.01 per share (the "Company Common Stock"),
     set forth opposite Stockholder's name on Schedule A hereto (the
     "Existing Shares", and together with any shares of Company Common
     Stock acquired by Stockholder after the date hereof and prior to the
     termination hereof, whether upon exercise of options or warrants,
     conversion of convertible securities, purchase, exchange or otherwise,
     the "Shares").

          (ii)  On the date hereof, the Existing Shares set forth opposite
     Stockholder's name on Schedule A constitute all of the shares of
     Company Common Stock owned by Stockholder.

          (iii) Stockholder has (A) sole power of disposition; (B) sole
     voting power; and (C) sole power to demand dissenter's or appraisal
     rights, in each case with respect to all of Stockholder's Existing
     Shares and with no restrictions on such rights, subject to applicable
     federal securities laws and the terms of this Agreement.

          (b)  POWER; BINDING AGREEMENT.  Stockholder has all requisite
     legal capacity, power and authority to enter into and perform all of
     Stockholder's obligations under this Agreement.  The execution,
     delivery and performance of this Agreement by Stockholder will not
     violate any other agreement to which Stockholder is a party or by
     which Stockholder is bound including, without limitation, any voting
     agreement, stockholders agreement, voting trust or other agreement.
     This Agreement has been duly and validly authorized, executed and
     delivered by Stockholder and constitutes a valid and binding agreement
     of Stockholder, enforceable against Stockholder in accordance with its
     terms, except as such enforceability may be limited by bankruptcy,
     insolvency, moratorium or other similar laws affecting or relating to
     the enforcement of creditors' rights generally or by general
     principles of equity.  There is no beneficiary of or holder of a
     voting trust certificate whose consent is required for the execution
     and delivery of this Agreement or the consummation of the transactions
     contemplated hereby.

          (c)  NO CONFLICTS.  Except for filing under the Hart-Scott-Rodino
     Antitrust Improvements Act of 1976, as amended (the "HSR Act"), if
     applicable, (I) no filing with, and no permit, authorization, consent
     or approval of, any state or federal public body or authority is
     necessary for the execution of this Agreement by Stockholder and the
     consummation by Stockholder of the transactions contemplated hereby
     and (II) neither the execution and delivery of this Agreement by
     Stockholder nor the consummation by Stockholder of the transactions
     contemplated hereby nor compliance by Stockholder with any of the
     provisions hereof shall (A) conflict with or result in any breach of
     the applicable organization documents applicable to Stockholder, (B)
     result in a material violation or breach of, or constitute (with or
     without notice or lapse of time or both) a default (or give rise to

                                 Exh. A-2
<PAGE>

     any third party right of termination, cancellation, modification,
     prepayment or acceleration) under any of the terms, conditions or
     provisions of any material note, bond, mortgage, indenture, license,
     contract, commitment, arrangement, understanding, agreement or other
     instrument or obligation of any kind to which Stockholder is a party
     or by which such Stockholder or any of such Stockholder's properties
     or assets may be bound or (C) violate any order, writ, injunction,
     decree, judgment, statute, rule, regulation or governmental permit or
     license (collectively, "Laws") applicable to Stockholder or any of
     such Stockholder's properties or assets.

          (d)  Stockholder's Shares and the certificates representing
     Shares are now and at all times during the term hereof will be held by
     Stockholder, or by a nominee or custodian for the benefit of
     Stockholder, free and clear of all liens, claims, security interests,
     proxies, voting trusts or agreements, understandings, arrangements or
     any other encumbrances whatsoever, except for any such encumbrances or
     proxies arising hereunder.

           (e)   No broker, investment banker, financial adviser or other
     Person is entitled to any broker's, finder's, financial adviser's or
     other similar fee or commission payable by Parent or Purchaser in
     connection with the transactions contemplated hereby based upon
     arrangements made by or on behalf of Stockholder.

          (f)  Stockholder understands and acknowledges that Parent is
     entering into the Merger Agreement in reliance upon Stockholder's
     execution and delivery of this Agreement.

          2.   AGREEMENT TO TENDER.  Stockholder hereby irrevocably agrees
to duly tender all of the Shares of Stockholder pursuant to the terms of
the Offer and not to withdraw such Shares prior to the expiration of the
Offer.

          3.   AGREEMENT TO VOTE; PROXY.

          (a)  VOTING.  Stockholder hereby agrees that, during the time
this Agreement is in effect, at any meeting of the stockholders of the
Company, however called, or in connection with any written consent of the
stockholders of the Company, Stockholder shall vote (or cause to be voted)
the Shares of Stockholder (I) in favor of the Merger, the execution and
delivery by the Company of the Merger Agreement and the approval of the
terms thereof and each of the other actions contemplated by the Merger
Agreement and this Agreement and any actions required in furtherance hereof
and thereof; (II) against any action or agreement that would result in a
breach of any covenant, representation or warranty or any other obligation
or agreement of the Company under the Merger Agreement, the Offer or this
Agreement; and (III) except as specifically requested in writing by Parent
in advance, against the following actions (other than the Merger and the
transactions contemplated by the Merger Agreement): (A) any extraordinary
corporate transaction, such as a merger, consolidation or other business
combination involving the Company or its subsidiaries; (B) a sale, lease or

                                Exh. A-3
<PAGE>


transfer of a material amount of assets of the Company or its subsidiaries
or a reorganization, recapitalization, dissolution, liquidation or winding
up of the Company or any of its subsidiaries; (C) any change in the
majority of the board of directors of the Company; (D) any material change
in the present capitalization of the Company or any amendment of the
Company's Certificate of Incorporation; (E) any other material change in
the Company's corporate structure or business; and (F) any other action
which is intended or could reasonably be expected to impede, interfere
with, delay, postpone, discourage or materially adversely affect the
Merger, the transactions contemplated by the Merger Agreement or this
Agreement or the contemplated economic benefits of any of the foregoing.
Stockholder shall not enter into any agreement or understanding with any
Person prior to the Termination Date (as defined in Section 9 hereof) to
vote in any manner inconsistent with clause (i), (ii) or (iii) of the
preceding sentence.

          (b)  PROXY.  STOCKHOLDER HEREBY GRANTS TO, AND APPOINTS
PURCHASER, PETER THAUER AND PETER TRACEY IN THEIR RESPECTIVE CAPACITIES AS
OFFICERS OF PURCHASER, AND ANY INDIVIDUAL WHO SHALL HEREAFTER SUCCEED TO
ANY SUCH OFFICE OF PURCHASER, AND ANY OTHER DESIGNEE OF PURCHASER, EACH OF
THEM INDIVIDUALLY, SUCH STOCKHOLDER'S IRREVOCABLE (UNTIL THE TERMINATION
DATE) PROXY AND ATTORNEY-IN-FACT (WITH FULL POWER OF SUBSTITUTION) TO VOTE
THE SHARES AS INDICATED IN SECTION 3(a) ABOVE.  STOCKHOLDER INTENDS THIS
PROXY TO BE IRREVOCABLE (UNTIL THE TERMINATION DATE) AND COUPLED WITH AN
INTEREST AND WILL TAKE SUCH FURTHER ACTION AND EXECUTE SUCH OTHER
INSTRUMENTS AS MAY BE NECESSARY TO EFFECTUATE THE INTENT OF THIS PROXY AND
HEREBY REVOKES ANY PROXY PREVIOUSLY GRANTED BY STOCKHOLDER WITH RESPECT TO
STOCKHOLDER'S SHARES.

          4.   CERTAIN COVENANTS OF STOCKHOLDER.  Except in accordance with
the terms of this Agreement, Stockholder hereby covenants and agrees as
follows:

          (a)  NO SOLICITATION.  Stockholder shall not, directly or
indirectly (including through advisors, agents or other intermediaries),
initiate, solicit, negotiate, encourage or provide confidential information
to facilitate any proposal or offer by any Person that constitutes or could
reasonably be expected to lead to an Acquisition Transaction; provided,
however, that no provision of this Agreement shall prohibit or in any way
restrict the right of Stockholder and its affiliates to initiate, solicit,
negotiate, encourage or provide confidential information to any party in
connection with a possible sale or other disposition by Stockholder or such
affiliate of its interest in Boehringer Ingelheim Bioproducts, a Delaware
general partnership.  If Stockholder receives any such inquiry or proposal,
then Stockholder shall promptly inform Parent of the material terms and
conditions, if any, of such inquiry or proposal and the identity of the
Person making it.  Stockholder will immediately cease and cause to be
terminated any existing activities, discussions or negotiations with any
parties conducted heretofore with respect to any of the foregoing.  Nothing
in this Section 4(a) shall restrict or limit the ability of Stockholder's
designee on the Board of Directors of the Company to take or perform in
such capacity any of the actions or do any of the things that the Company
is permitted to take or perform under Section 4.1(a) and 4.1(b) of the
Merger Agreement.

                                 Exh. A-4
<PAGE>

          (b)  RESTRICTION ON TRANSFER, PROXIES AND NON-INTERFERENCE;
RESTRICTION ON WITHDRAWAL.  Stockholder shall not, directly or indirectly:
(I) except pursuant to the terms of the Merger Agreement, the Offer and
this Agreement, offer for sale, sell, transfer, tender, pledge, encumber,
assign or otherwise dispose of (collectively, "Disposition"), enforce or
permit the execution of the provisions of any agreement with the Company
whereby the Company may be obligated to repurchase, or enter into any other
contract, option or other arrangement or understanding with respect to, or
otherwise consent to the Disposition of any or all of Stockholder's Shares
or any interest therein; (II) except as contemplated hereby, grant any
proxies or powers of attorney, deposit any Shares into a voting trust or
enter into a voting agreement with respect to any Shares; or (III) take any
action that would make any representation or warranty of Stockholder
contained herein untrue or incorrect or have the effect of preventing or
disabling Stockholder from performing Stockholder's obligations under this
Agreement.

          (c)  WAIVER OF APPRAISAL AND DISSENTER'S RIGHTS.  Stockholder
hereby waives any rights of appraisal or rights to dissent from the Merger
that Stockholder may have.

          5.   OPTION.  (a)  Stockholder hereby grants to Purchaser an
irrevocable option (the "Option") to purchase Stockholder's Shares, on the
terms and subject to the conditions set forth herein.

     (b)  The Option may be exercised by Purchaser, as a whole and not in
part, at any time and from time to time from and after any time when the
Merger Agreement has been terminated in accordance with its terms and prior
to the Termination Date, subject to the conditions set forth in Section
5(f).

          (c)  If Purchaser wishes to exercise the Option, Purchaser shall
send a written notice (the "Option Notice") to Stockholder of its intention
to exercise the Option, specifying the place, and, if then known, the time
and the date (the "Closing Date") of the closing (the "Closing") of the
purchase.  The Closing Date shall occur on the third business day after the
date on which such notice is delivered.

          (d)  At the Closing, Stockholder shall deliver to Purchaser (or
its designee) all of Stockholder's Shares required to be delivered pursuant
to the Option Notice by delivery of a certificate or certificates
evidencing such Shares, duly endorsed to Purchaser or accompanied by stock
powers duly executed in favor of Purchaser, with all necessary stock
transfer stamps affixed.

          (e)  At the Closing, Purchaser shall pay, and Parent shall cause
Purchaser to pay, to Stockholder, by wire transfer in immediately available
funds to an account specified by Stockholder in writing no more than two
days prior to the Closing, an amount equal to the product of the Merger
Consideration and the number of shares purchased pursuant to the exercise
of the Option.

                                Exh. A-5
<PAGE>

          (f)  The Closing shall be subject to the satisfaction of each of
the following conditions:

          (i)  no court, arbitrator or governmental body, agency or
     official shall have issued any order, decree or ruling and there shall
     not be any statute, rule or regulation, restraining, enjoining or
     prohibiting the consummation of the purchase and sale of the Shares
     pursuant to the exercise of the Option;

          (ii)  any waiting period applicable to the consummation of the
     purchase and sale of the Shares pursuant to the exercise of the Option
     under the HSR Act shall have expired or been terminated; and

          (iii)  all actions by or in respect of, and any filing with, any
     governmental body, agency, official, or authority required to permit
     the consummation of the purchase and sale of the Shares pursuant to
     the exercise of the Option shall have been obtained or made and shall
     be in full force and effect.

          6.   FURTHER ASSURANCES.  From time to time, at any party's
request and without further consideration, each other party shall execute
and deliver such additional documents and take all such further action as
may be necessary or desirable to consummate and make effective, in the most
expeditious manner practicable, the transactions contemplated by this
Agreement.

          7.   OBLIGATIONS ATTACH TO SHARES.  Stockholder agrees that this
Agreement and the obligations hereunder shall attach to such Stockholder's
Shares and shall be binding upon any Person to which legal or beneficial
ownership of such Shares shall pass, whether by operation of law or
otherwise.

          8.   STOP TRANSFER.  Stockholder agrees with, and covenants
to, Parent that Stockholder shall not request that the Company register the
transfer (book-entry or otherwise) of any certificate or uncertificated
interest representing any of Stockholder's Shares, unless such transfer is
made in compliance with the Offer or this Agreement.  Stockholder agrees,
with respect to any Shares in certificated form, that Stockholder will
submit to the Company, within ten business days after the date hereof, the
certificates representing such Shares in order for the Company to inscribe
upon such certificates the following legend: "The shares of Common Stock,
par value $.0l per share, of BioWhittaker, Inc. (the "Company") represented
by this certificate are subject to a Stockholders Agreement dated as of
August 22, 1997, and may not be sold or otherwise transferred, except in
accordance therewith.  Copies of such Agreement may be obtained at the
principal executive offices of the Company."  Stockholder agrees that
within ten business days after the date hereof, Stockholder will no longer
hold any Shares, whether certificated or uncertificated, in "street name"
or in the name of any nominee.

          9.   TERMINATION.  This Agreement shall terminate upon the
earlier of (a) twelve months from the date hereof or (b) the Effective
Time; PROVIDED, HOWEVER, that if the Company is not in breach of its

                              Exh. A-6
<PAGE>

obligations under the Merger Agreement and Stockholder is not in breach of
its obligations under this Agreement, this Agreement shall terminate upon
termination of the Merger Agreement (a) pursuant to Section 6.1(a), 6.1(d),
6.1(f)(i) and 6.1(g) thereof, (b) pursuant to Section 6.1(b), 6.1(c) and
6.1(e) thereof (in each case if no proposal for an Acquisition Transaction
has been made), or (c) by the Company pursuant to Section 6.1(f)(ii)
thereof (unless a proposal for an Acquisition Transaction has been made).
The date of termination of this Agreement is referred to herein as the
"Termination Date".

          10.  MISCELLANEOUS.

          (a)  ENTIRE AGREEMENT; ASSIGNMENT. This Agreement (I) constitutes
the entire agreement among the parties with respect to the subject matter
hereof and supersedes all other prior agreements and understandings, both
written and oral, among the parties with respect to the subject matter
hereof and (II) shall not be assigned by operation of law or otherwise
without the prior written consent of (A) in the case of an assignment by
Stockholder, Parent and (B) in the case of an assignment by Parent or
Purchaser, Stockholder, provided that Parent may in its sole discretion
assign its rights and obligations hereunder to any of its direct or
indirect wholly-owned subsidiaries.

          (b)  AMENDMENTS.  This Agreement may not be modified, amended,
altered or supplemented, except upon the execution and delivery of a
written agreement executed the parties hereto.

          (c)  NOTICES.  All notices and other communications under this
Agreement shall be in writing and shall be given (and shall be deemed to
have been duly given upon receipt) by delivery in person, facsimile, telex
or other standard form of telecommunications, by courier service, or by
registered or certified mail, postage prepaid, return receipt requested,
addressed

          If to Parent or Purchaser, to:

               Cambrex Corporation
               One Meadowlands Plaza
               East Rutherford, New Jersey  07073
               Facsimile No.: (201) 804-9851
               Attention:  Peter Thauer, Esq.

          With a copy to:

               Debevoise & Plimpton
               875 Third Avenue
               New York New York  10022
               Facsimile No.: (212) 909-6836
               Attention:  Ralph Arditi, Esq.

          If to Stockholder, to:


                                  Exh. A-7      
<PAGE>

               ANASCO GmbH
               D-55216 Ingelheim am Rhein
               Federal Republic of Germany
               Facsimile No.: 011-44-6132-77-4080

          With copies to:

               Boehringer Ingelheim GmbH
               Bereich Recht Marken Versicherung Immobilien
               D-55216 Ingelheim am Rhein
               Federal Republic of Germany
               Facsimile No.: 011-44-6132-77-3256

          and:

               Rogers & Wells
               200 Park Avenue
               New York, New York 10166
               Facsimile No.: (212) 878-8375
               Attention:  Richard T. McDermott, Esq.

or to such other address or facsimile number as the Person to whom notice
is given shall have previously furnished to the others in writing in the
manner set forth above.

          (d)  GOVERNING LAW.  This Agreement shall be governed by and
construed in accordance with the laws of the State of Delaware without
giving effect to the conflicts of laws principles thereof.

          (e)  ENFORCEMENT.  The parties agree that irreparable damage
would occur in the event that any of the provisions of this Agreement were
not performed in accordance with their specific terms or were otherwise
breached.  It is accordingly agreed that the parties shall be entitled to
an injunction or injunctions to prevent breaches of this Agreement and to
enforce specifically the terms and provisions of this Agreement.

          (f)  COUNTERPARTS.  This Agreement may be executed in one or more
counterparts, each of which shall be deemed to be an original, but all of
which when taken together shall constitute one and the same Agreement.

          (g)  DESCRIPTIVE HEADINGS.  The descriptive headings used herein
are inserted for convenience of reference only and are not intended to be
part of or to affect the meaning or interpretation of this Agreement.

          (h)  SEVERABILITY.  Whenever possible, each provision or portion
of any provision of this Agreement will be interpreted in such manner as to
be effective and valid under applicable law but if any provision or portion
of any provision of this Agreement is held to be invalid, illegal or

                                Exh. A-8
<PAGE>

unenforceable in any respect under any applicable law or rule in any
jurisdiction, such invalidity, illegality or unenforceability will not
affect any other provision or portion of any provision in such
jurisdiction, and this Agreement will be reformed, construed and enforced
in such jurisdiction as if such invalid, illegal or unenforceable provision
or portion of any provision had never been contained herein.

          (i)  DEFINITIONS; CONSTRUCTION.  For purposes of this Agreement:

          (I)  "beneficially own" or "beneficial ownership" with respect to
     any securities shall mean having "beneficial ownership" of such
     securities (as determined pursuant to Rule 13d-3 under the Exchange
     Act), including pursuant to any agreement, arrangement or
     understanding, whether or not in writing.  Without duplicative
     counting of the same securities by the same holder, securities
     beneficially owned by a Person shall include securities beneficially
     owned by all other Persons with whom such Person would constitute a
     "group" as described in Section 13(d)(3) of the Exchange Act.

          (IV)  "Person" shall mean an individual, corporation,
     partnership, limited liability company, joint venture, association,
     trust, unincorporated organization or other entity.

          (V)  In the event of a stock dividend or distribution, or any
     change in the Company Common Stock by reason of any stock dividend,
     split-up, recapitalization, combination, exchange of shares or the
     like, the term "Shares" shall be deemed to refer to and include the
     Shares as well as all such stock dividends and distributions and any
     shares into which or for which any or all of the Shares may be changed
     or exchanged.

          (j)  STOCK PURCHASE AGREEMENT.  Stockholder acknowledges that its
rights under Section 8.01(c) of the Stock Purchase Agreement, dated
September 24, 1991, between the Company and Stockholder, to receive any
Compensation Amount (as defined in such agreement) will terminate and be of
no further force or effect from and after its sale of its Shares to the
Purchaser in the Offer, as contemplated in this Agreement.

                                 Exh. A-9
<PAGE>

          IN WITNESS WHEREOF, Parent, Purchaser and Stockholder have caused
this Agreement to be duly executed as of the day and year first above
written.

                         CAMBREX CORPORATION


                         BY:  ____________________
                              Name:
                              Title:


                         BW ACQUISITION CORPORATION


                         BY:  ____________________
                              Name:
                              Title:


                         ANASCO GmbH


                         BY:  ____________________
                              Name:
                              Title:


                         BY:  ____________________
                              Name:
                              Title:

                                   Exh. A-10
<PAGE>

                                                                Schedule A


NAME                                     NUMBER OF SHARES

ANASCO GmbH                              2,097,043
D-55216 Ingelheim am Rhein
Federal Republic of Germany
Facsimile No.: 011-44-6132-77-4080



                                       Exh. A-11


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