DUSA PHARMACEUTICALS INC
S-8, 1999-12-07
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1
    As filed with the Securities and Exchange Commission on December 7, 1999

                                                           Registration No. 333-
================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                                    FORM S-8
             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                           DUSA PHARMACEUTICALS, INC.
             (Exact name of registrant as specified in its charter)

                      NEW JERSEY                        22-3103129
             (State or other jurisdiction             (I.R.S. Employer
           of incorporation or organization)         Identification No.)


                                 25 UPTON DRIVE
                         WILMINGTON, MASSACHUSETTS 02061
                                 (978) 657-7500
               (Address, including ZIP code, and telephone number,
        including area code, of registrant's principal executive offices)

             1991 INCENTIVE STOCK OPTION PLAN OF DEPRENYL USA, INC.
          DUSA PHARMACEUTICALS, INC. 1994 RESTRICTED STOCK OPTION PLAN
            DUSA PHARMACEUTICALS, INC. 1996 OMNIBUS PLAN, AS AMENDED
                 STOCK OPTION AGREEMENTS FOR D. GEOFFREY SHULMAN
                   STOCK OPTION AGREEMENT FOR JAMES P. DOHERTY
                    STOCK OPTION AGREEMENT FOR THEODORE SALL
                  STOCK OPTION AGREEMENT FOR RICHARD C. LUFKIN
                 STOCK OPTION AGREEMENT FOR HERBERT F. HABERMAN
                  STOCK OPTION AGREEMENTS FOR JAMES C. KENNEDY
                   STOCK OPTION AGREEMENTS FOR ROY H. POTTIER
                   STOCK OPTION AGREEMENTS FOR ROBERT L. REID
                    STOCK OPTION AGREEMENT FOR DEAN VAN VUGT
                    STOCK OPTION AGREEMENT FOR MARTIN BARKIN
                  STOCK OPTION AGREEMENTS FOR RONALD L. CARROLL
                    STOCK OPTION AGREEMENTS FOR SCOTT LUNDAHL
                  STOCK OPTION AGREEMENT FOR DANIEL PIACQUADIO
                     STOCK OPTION AGREEMENT FOR ALLYN GOLUB
                     STOCK OPTION AGREEMENT FOR DAVID COHEN
                CLASS B WARRANT AGREEMENT FOR D. GEOFFREY SHULMAN
                            (Full title of the plans)

                            NANETTE W. MANTELL, ESQ.
                                LANE AND MANTELL
                         991 ROUTE 22 WEST, PO BOX 8539
                          SOMERVILLE, NEW JERSEY 08876
                                 (908) 253-9333

            (Name, address, including ZIP code, and telephone number,
                   including area code, of agent for service)

                                   COPIES TO:
                       DR. D. GEOFFREY SHULMAN, PRESIDENT
                           DUSA PHARMACEUTICALS, INC.
                                 25 UPTON DRIVE
                         WILMINGTON, MASSACHUSETTS 02061
                                 (978) 657-7500


<PAGE>   2

                         CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
==============================================================================================================================
                                                             Amount       Proposed Maximum    Proposed Maximum    Amount of
               Title of Each Class of Securities              to be      Offering Price Per  Aggregate Offering   Registration
                       to be Registered                   Registered(1)         Share               Price            Fee
- ------------------------------------------------------------------------------------------------------------------------------
<S>                                                       <C>            <C>                 <C>                  <C>
1991 Incentive Stock Option Plan -
   Shares of common stock no par value (options issued
   and outstanding)                                             80,000         $ 5.15(2)        $   412,000.00     $   108.77
- ------------------------------------------------------------------------------------------------------------------------------
1994 Restricted Stock Option Plan -
   Shares of common stock no par value (options issued
   and outstanding)                                             65,000         $ 3.38(2)        $   219,700.00     $    58.00
- ------------------------------------------------------------------------------------------------------------------------------
1996 Omnibus Plan, as Amended -
   Shares of common stock no par value (options reserved
   for future grants)                                          546,878         $19.00(3)        $10,390,682.00     $ 2,743.14
- ------------------------------------------------------------------------------------------------------------------------------
1996 Omnibus Plan, as Amended -
   Shares of common stock no par value  (options issued
   and outstanding)                                          1,165,166         $ 9.22(2)        $10,742,830.52     $ 2,836.11
- ------------------------------------------------------------------------------------------------------------------------------
Shares of common stock without par value (4)                   734,811         $ 6.22(2)        $ 4,570,524.42     $ 1,206.62
- ------------------------------------------------------------------------------------------------------------------------------

TOTAL REGISTRATION FEE.............................................................................................$ 6,952.64

==============================================================================================================================
</TABLE>


         (1)      Together with an indeterminate number of additional shares
                  which may be issued pursuant to the various DUSA Plans as a
                  result of stock splits, stock dividends or similar
                  transactions in accordance with Rule 416.

         (2)      Estimated solely for the purpose of calculating the
                  registration fee pursuant to Rule 457(h)(1) of the Securities
                  Act of 1933, as amended, based upon the average exercise price
                  of the outstanding options rounded to the nearest cent.

         (3)      Estimated solely for the purpose of calculating the
                  registration fee pursuant to Rule 457(h)(1) of the Securities
                  Act of 1933, as amended, based upon the average of the high
                  and low price as reported on The NASDAQ National Market on
                  November 30, 1999.

         (4)      The securities to be registered are shares of common stock
                  issuable upon exercise of options or warrants including 75,000
                  shares under the Stock Option Agreements for D. Geoffrey
                  Shulman; 37,500 shares under the Stock Option Agreement for
                  James P. Doherty; 10,000 shares under the Stock Option
                  Agreement for Theodore Sall; 12,500 shares under the Stock
                  Option Agreement for Richard C. Lufkin; 2,800 shares under the
                  Stock Option Agreement for Herbert F. Haberman; 33,200 shares
                  under the Stock Option Agreements for James C. Kennedy; 24,250
                  shares under the Stock Option Agreements for Roy H. Pottier;
                  26,800 shares under the Stock Option Agreements for Robert L.
                  Reid; 2,261 shares under the Stock Option Agreement for Dean
                  Van Vugt; 15,500 shares under the Stock Option Agreement for
                  Martin Barkin; 60,000 shares under the Stock Option Agreements
                  for Ronald L. Carroll; 60,000 shares under the Stock Option
                  Agreements for Scott Lundahl; 15,000 shares under the Stock
                  Option Agreement for Daniel Piacquadio; 5,000 shares under the
                  Stock Option Agreement for Allyn Golub; 5,000 shares under the
                  Stock Option Agreement for David Cohen; and 350,000 shares
                  under the Class B Warrant Agreement for D. Geoffrey Shulman.


<PAGE>   3

                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS

         The documents containing the information required by Part I of Form S-8
have been or will be sent or given to the participants in each of the Plans
being registered hereby as specified by Rule 428(b)(1) of Regulation C under the
Securities Act of 1933, as amended, and such documents taken together with the
documents incorporated by reference in this registration statement shall
constitute a prospectus that meets the requirements of Section 10(a) of the
Securities Act.

         Pursuant to Rule 428 of the Securities Act such documents are not
required to be filed with the SEC as part of this registration statement or as
an Exhibit hereto.

                                     PART II

            INFORMATION REQUIRED TO BE IN THE REGISTRATION STATEMENT

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE

         DUSA hereby incorporates by reference in this registration statement
the following documents previously filed by the registrant with the SEC:

         -        Annual Report on Form 10-K for the year ended December 31,
                  1998.

         -        Quarterly Reports on Form 10-Q for the quarters ended March
                  31, 1999, June 30, 1999 and September 30, 1999.

         -        Seven Current Reports on Form 8-K, including the exhibits: one
                  dated January 7, 1999 which was filed on January 11, 1999; one
                  dated and filed on January 14, 1999; one dated and filed on
                  June 11, 1999; one dated and filed on June 29, 1999; one dated
                  and filed on October 14, 1999; one dated November 22, 1999 and
                  filed on November 24, 1999; and one dated and filed on
                  December 6, 1999.

         -        The description of DUSA's common stock contained in its
                  registration statement on Form 8-A which was filed on January
                  3, 1992, amended on October 24, 1997 (and in DUSA's Quarterly
                  Report on Form 10-Q which was filed on November 12, 1997).

         -        All documents subsequently filed by DUSA pursuant to Sections
                  13(a), 13(c), 14 and 15(d) of the Exchange Act of 1934, as
                  amended, on or after the date of this registration statement
                  and prior to the filing of a post-effective amendment which
                  indicates that all securities offered have been sold or which
                  deregisters all securities then remaining unsold shall be
                  deemed to be incorporated by reference in this registration
                  statement and to be part hereof from the date of filing of
                  such documents.

ITEM 4.  DESCRIPTION OF SECURITIES

         Not applicable.


                                       1
<PAGE>   4

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL

         The validity of the securities offered hereby will be passed upon by
Lane and Mantell, a professional corporation, Somerville, New Jersey. As of
December 6, 1999, shareholders and associates of Lane and Mantell beneficially
own, directly or indirectly, less than 1% of the common stock of DUSA.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

         Article 5 of the Company's Certificate of Incorporation, as amended,
and New Jersey Business Corporation Act, N.J.S.A. 14A:2-7 provide as follows:

         Any director and officer of the Corporation shall not be personally
         liable to the Corporation or its shareholders for damages for breach of
         any duty owed to the Corporation or its shareholders, except that this
         provision shall not relieve a director or officer from liability for
         any breach of duty based upon an act or omission (a) in breach of such
         person's duty of loyalty to the Corporation or its shareholders; (b)
         not in good faith or involving a knowing violation of law; or (c)
         resulting in receipt by such person of an improper personal benefit.

         The Company's By-laws, as amended, pursuant to the New Jersey Business
Corporation Act, N.J.S.A. 14A:3-5, provide as follows:

                                   ARTICLE IV
                                 INDEMNIFICATION

         Section 1. Actions by Others. The Corporation (1) shall indemnify any
person who was or is a party or is threatened to be made a party to any
threatened, pending or completed action, suit or proceeding, whether civil,
criminal, administrative or investigative (other than an action by or in the
right of the Corporation) by reason of the fact that he is or was a director,
officer or trustee of the Corporation or of any constituent corporation absorbed
by the Corporation in a consolidation or merger and (2) except as otherwise
required by Section 3 of this Article, may indemnify any person who was or is a
party or is threatened to be made a party to any threatened, pending or
completed action, suit or proceeding, whether civil, criminal, administrative or
investigative (other than an action by or in the right of the Corporation) by
reason of the fact that he (a) is or was an employee or agent or the legal
representative of a director, officer, trustee, employee or agent of the
Corporation or of any absorbed constituent corporation, or (b) is or was serving
at the request of the Corporation or of any absorbed constituent corporation as
a director, officer, employee, agent of or participant in another corporation,
partnership, joint venture, trust or other enterprise, or the legal
representative of such a person against expenses, costs, disbursements
(including attorneys' fees), judgments, fines and amounts actually and
reasonably incurred by him in good faith and in connection with such action,
suit or proceeding if he acted in a manner he reasonably believed to be in or
not opposed to the best interests of the Corporation, and with respect to any
criminal action or proceeding, he had no reasonable cause to believe that his
conduct was unlawful. The termination of any action, suit or proceeding by
judgment, order, settlement, conviction, or upon a pleas of nolo contendere or
its equivalent, shall not, of itself, create a presumption that the person did
not meet the applicable standard of conduct.

         Section 2. Actions by or in the Right of the Corporation. The
Corporation shall indemnify any person who was or is a party or is threatened to
be made a party to any threatened, pending or completed action or suit by or in
the right of the Corporation to procure a judgment in its favor by reason of the
fact that he is or was a director, officer, trustee, employee or agent of the
Corporation or of any constituent


                                       2
<PAGE>   5

corporation absorbed by the Corporation by consolidation or merger, or the legal
representative of any such person, or is or was serving at the request of the
Corporation or of any absorbed constituent corporation, as a director, officer,
trustee, employee, agent of or participant, or the legal representative of any
such person in another corporation, partnership, joint venture, trust or other
enterprise against expenses (including attorneys' fees) actually and reasonably
incurred by him in connection with the defense or settlement of such action or
suit if he acted in good faith and in a manner he reasonably believed to be in
or not opposed to the best interests of the Corporation and except that no
indemnification shall be made in respect of any claim, issue or matter as to
which such person shall have been adjudged to be liable to the Corporation
unless and only to the extent that the New Jersey Superior Court or the court in
which such action or suit was brought shall determine upon application that,
despite the adjudication of liability but in view of all the circumstances of
the case, such person is fairly and reasonably entitled to indemnity for such
expenses which the New Jersey Superior Court or such other court shall deem
proper.

         Section 3. Successful Defense. To the extent that a person who is or
was a director, officer, trustee, employee or agent of the Corporation or of any
constituent corporation absorbed by the Corporation by consolidation or merger,
or the legal representative of any such person, has been successful on the
merits or otherwise in defense of any action, suit proceeding referred to in
Section 1 or Section 2 of this Article, or in defense of any claim, issue, or
matter therein, he shall be indemnified against expenses (including attorneys'
fees) actually and reasonably incurred by him in connection therewith.

         Section 4. Specific Authorization. Any indemnification under Section 1
or Section 2 of this Article (unless ordered by a court) shall be made by the
Corporation only as authorized in the specific case upon a determination that
indemnification of the director, officer, trustee, employee, agent, or the legal
representative thereof, is proper in the circumstances because he has met the
applicable standard of conduct set forth in said Sections 1 and 2. Such
determination shall be made (1) by the Board of Directors by a majority vote of
quorum consisting of directors who were not parties to such action, suit or
proceeding, or (2) if such a quorum is not obtainable, a quorum of disinterested
directors so directs, by independent legal counsel for a written opinion, (3) by
the shareholders.

         Section 5. Advance of Expenses. Expenses incurred by any person who may
have a right of indemnification under this Article in defending civil or
criminal action, suit or proceeding may be paid by the Corporation in advance of
the final distribution of such action, suit or proceeding as authorized by the
board of directors upon receipt of an undertaking by or on behalf of the
director, officer, trustee, employee, or the legal representative thereof, to
repay such amount unless it shall ultimately be determined that he is entitled
to be indemnified by the Corporation pursuant to this Article.

         Section 6. Right of Indemnity not Exclusive. The indemnification and
advancement of expenses provided by this Article shall not exclude any other
rights to which those seeking indemnification may be entitled under the
certificate of incorporation of the Corporation or any By-Law agreement, vote of
shareholders or otherwise; provided that no indemnification shall be made to or
on behalf of a Director, officer, trustee, employee, agent, or legal
representative if a judgment or other final adjudication adverse to such persons
establishes that his acts or omissions (a) were in breach of his duty of loyalty
to the corporation or its shareholders, (b) were not in good faith or involved a
knowing violation of law or (c) resulted in receipt by such person of an
improper personal benefit.

         Section 7. Insurance. The Corporation may purchase and maintain
insurance on behalf of any person who is or was a director, officer, trustee,
employee or agent of the Corporation or of any constituent corporation absorbed
by the Corporation by consolidation or merger of the legal representative of
such person or is or was serving at the request of the Corporation or of any
absorbed constituent corporation as a director, officer, trustee, employee or
agent of or participant in another corporation, partnership, joint venture,
trust or other enterprise, or the legal representative of any such person
against any liability asserted against him and incurred by him in any such
capacity, arising out of his status as such or by reason of his


                                       3
<PAGE>   6

being or having been such, whether or not the Corporation would have the power
to indemnify him against such liability under the provisions of this Article,
the New Jersey Business Corporation Act, or otherwise.

         Section 8. Invalidity of any Provision of this Article. The invalidity
or unenforceability of any provision of this Article shall not affect the
validity or enforceability of the remaining provisions of this Article.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED

         Not applicable.

ITEM 8.  EXHIBITS

          (4.1)   1991 Incentive Stock Option Plan of Deprenyl USA, Inc.
          (4.2)   DUSA Pharmaceuticals, Inc. 1994 Restricted Stock Option Plan
          (4.3)   DUSA Pharmaceuticals, Inc. 1996 Omnibus Plan, as Amended
          (4.4)   Stock Option Agreements for D. Geoffrey Shulman
          (4.5)   Stock Option Agreement for James P. Doherty
          (4.6)   Stock Option Agreement for Theodore Sall
          (4.7)   Stock Option Agreement for Richard C. Lufkin
          (4.8)   Stock Option Agreement for Herbert F. Haberman
          (4.9)   Stock Option Agreements for James C. Kennedy
          (4.10)  Stock Option Agreements for Roy H. Pottier
          (4.11)  Stock Option Agreements for Robert L. Reid
          (4.12)  Stock Option Agreement for Dean Van Vugt
          (4.13)  Stock Option Agreement for Martin Barkin
          (4.14)  Stock Option Agreements for Ronald L. Carroll
          (4.15)  Stock Option Agreements for Scott Lundahl
          (4.16)  Stock Option Agreement for Daniel Piacquadio
          (4.17)  Stock Option Agreement for Allyn Golub
          (4.18)  Stock Option Agreement for David Cohen
          (4.19)  Class B Warrant Agreement for D. Geoffrey Shulman

          (5.1)   Opinion of Lane and Mantell

          (23.1)  Consent of Deloitte & Touche LLP
          (23.2)  Consent of Lane and Mantell (contained in Exhibit 5.1)

          (24.1)  Power of Attorney (See Page i)

          (99.1)  Form of 1991 Incentive Stock Option Agreement
          (99.2)  Form of 1994 Restricted Stock Option Agreement
          (99.3)  Form of Omnibus Nonqualified Stock Option Agreement
          (99.4)  Form of Omnibus Incentive Stock Option Agreement
          (99.5)  Form of Omnibus Nonqualified Stock Option Agreement with
                  increasing Exercise Price
          (99.6)  Form of Omnibus Incentive Stock Option Agreement with
                  increasing Exercise Price

ITEM 9.  UNDERTAKINGS

         (A)(1) The undersigned registrant hereby undertakes:


                                       4
<PAGE>   7

                  (i)   To file, during any period in which offers or sales are
being made, a post-effective amendment to this registration statement to include
any material information with respect to the plan of distribution not previously
disclosed in the registration statement or any material change to such
information in the registration statement.

                  (ii)  That, for the purpose of determining any liability under
the Securities Act of 1933, each such post-effective amendment shall be deemed
to be a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be the
initial bona fide offering thereof.

                  (iii) To include any material information with respect to the
plan of distribution not previously disclosed in the registration statement or
any material change to such information in the registration statement;

              (2) That, for the purpose of determining any liability under the
Securities Act of 1933, each post-effective amendment shall be deemed to be a
new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof; and

              (3) To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at the
termination of the offering.

         (B) The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to section 13(a) or section 15(d) of the
Securities Exchange Act of 1934 (and, where applicable, each filing of an
employee benefit plan's annual report pursuant to section 15(d) of the
Securities Exchange Act of 1934) that is incorporated by reference in the
registration statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         (C) Insofar as indemnification for liabilities arising under the
Securities Act of 1933 may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions, or otherwise,
the registrant has been advised that in the opinion of the Securities and
Exchange Commission such indemnification is against public policy as expressed
in the Act and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.


                                       5
<PAGE>   8

                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Wilmington, State of Massachusetts, Country of the
United States, on December 7, 1999.


                                                      DUSA Pharmaceuticals, Inc.
                                                  ------------------------------
                                                                      Registrant


                                                     By: /s/ D. Geoffrey Shulman
                                                        ------------------------
                                                        Dr. D. Geoffrey Shulman,
                                                                       President

                                POWER OF ATTORNEY

         Know All Men By These Presents, that each person whose signature
appears below constitutes and appoints D. Geoffrey Shulman as true and lawful
attorney-in-fact and agent with full power of substitution and resubstitution,
for him and in his name, place and stead, in any and all capacities, to sign any
or all amendments (including post-effective amendments) to this registration
statement or any related registration statement that is to be effective upon
filing pursuant to Rule 462(b), and to file the same, with all exhibits thereto,
and other documents in connection therewith, with the Securities and Exchange
Commission, granting unto said attorney-in-fact and agent full power and
authority to do and perform each and every act and thing requisite and necessary
to be done in connection with the above premises, as fully to all intents and
purposes as he might or could do in person, hereby ratifying and confirming all
that said attorney-in-fact and agent or his substitute or substitutes, may
lawfully do or cause to be done by virtue thereof.

         Pursuant to the requirements of the Securities Act of 1933, this
registration statement has been signed by the following persons in the
capacities and on the dates indicated:


<TABLE>
<S>                                        <C>                                 <C>
s/D. Geoffrey Shulman                      Director, Chairman of the           December 7, 1999
- ----------------------------------         Board, President, Chief             ----------------
Geoffrey Shulman, MD, FRCPC                Executive Officer and Chief         Date
                                           Financial Officer (Principal
                                           Executive, Financial, and
                                           Accounting Officer)

s/Ronald L. Carroll                        Executive Vice President,           December 7, 1999
- ----------------------------------         Chief Operating Officer             ----------------
Ronald L. Carroll                                                              Date

s/Stuart L. Marcus                         Senior Vice President,              December 7, 1999
- ----------------------------------         Scientific Affairs                  ----------------
Stuart L. Marcus,  MD, PhD                                                     Date

s/Scott L. Lundahl                         Vice President,                     December 7, 1999
- ----------------------------------         Technology                          ----------------
Scott L. Lundahl                                                               Date

s/Gregory M. Torre                         Vice President,                     December 7, 1999
- ----------------------------------         Regulatory Affairs                  ----------------
Gregory M. Torre                                                               Date
</TABLE>


                                      -i-
<PAGE>   9

<TABLE>
<S>                                        <C>                                 <C>
s/Nanette W. Mantell                       Secretary                           December 7, 1999
- ----------------------------------                                             ----------------
Nanette W. Mantell, Esq.                                                       Date

s/John H. Abeles                           Director                            December 7, 1999
- ----------------------------------                                             ----------------
John H. Abeles, MD                                                             Date

s/James P. Doherty, BSc                    Director                            December 7, 1999
- ----------------------------------                                             ----------------
James P. Doherty, BSc                                                          Date

s/Jay M. Haft, Esq.                        Director                            December 7, 1999
- ----------------------------------                                             ----------------
Jay M. Haft, Esq.                                                              Date

s/Richard C. Lufkin                        Director                            December 7, 1999
- ----------------------------------                                             ----------------
Richard C. Lufkin                                                              Date

</TABLE>


                                      -ii-
<PAGE>   10

                                  EXHIBIT INDEX
<TABLE>
      <S>     <C>
      (4.1)   1991 Incentive Stock Option Plan of Deprenyl USA, Inc.............
      (4.2)   DUSA Pharmaceuticals, Inc. 1994 Restricted Stock Option Plan......
      (4.3)   DUSA Pharmaceuticals, Inc. 1996 Omnibus Plan, as Amended..........
      (4.4)   Stock Option Agreements for D. Geoffrey Shulman...................
      (4.5)   Stock Option Agreement for James P. Doherty.......................
      (4.6)   Stock Option Agreement for Theodore Sall..........................
      (4.7)   Stock Option Agreement for Richard C. Lufkin......................
      (4.8)   Stock Option Agreement for Herbert F. Haberman....................
      (4.9)   Stock Option Agreements for James C. Kennedy......................
      (4.10)  Stock Option Agreements for Roy H. Pottier........................
      (4.11)  Stock Option Agreements for Robert L. Reid........................
      (4.12)  Stock Option Agreement for Dean Van Vugt..........................
      (4.13)  Stock Option Agreement for Martin Barkin..........................
      (4.14)  Stock Option Agreements for Ronald L. Carroll.....................
      (4.15)  Stock Option Agreements for Scott Lundahl.........................
      (4.16)  Stock Option Agreement for Daniel Piacquadio......................
      (4.17)  Stock Option Agreement for Allyn Golub............................
      (4.18)  Stock Option Agreement for David Cohen............................
      (4.19)  Class B Warrant Agreement for D. Geoffrey Shulman.................

      (5.1)   Opinion of Lane and Mantell.......................................

      (23.1)  Consent of Deloitte & Touche LLP..................................
      (23.2)  Consent of Lane and Mantell (contained in Exhibit 5.1)............

      (24.1)  Power of Attorney (See Page i)....................................

      (99.1)  Form of 1991 Incentive Stock Option Agreement.....................
      (99.2)  Form of 1994 Restricted Stock Option Agreement....................
      (99.3)  Form of Omnibus Nonqualified Stock Option Agreement...............
      (99.4)  Form of Omnibus Incentive Stock Option Agreement..................
      (99.5)  Form of Omnibus Nonqualified Stock Option Agreement
                 with increasing Exercise Price.................................
      (99.6)  Form of Omnibus Incentive Stock Option Agreement
                 with increasing Exercise Price.................................
</TABLE>

<PAGE>   1
                                                                     Exhibit 4.1

                           INCENTIVE STOCK OPTION PLAN
                                       OF
                               DEPRENYL USA, INC.

                                    ARTICLE I
                              STATEMENT OF PURPOSE

         1.1 Purpose of the Plan. Under this incentive stock option plan (the
"Plan") of Deprenyl USA, Inc., (the "Company") options may be granted to
eligible employees (the "Optionees") to purchase shares of the Company's capital
stock. The Plan is designed to enable the Company and its subsidiaries to
attract, retain and motivate their employees by providing for or increasing the
proprietary interests of such employees in the Company. The Plan provides for
options which qualify as incentive stock options under Section 422 of the
Internal Revenue Code of 1986, as amended (the "Code").

                                   ARTICLE II
                           AMOUNT AND SOURCE OF STOCK

         2.1 Stock Subject to Plan. The maximum number of shares of stock for
which options granted hereunder may be exercised shall be four hundred twenty
thousand (420,000) shares of common stock, without par value, subject to the
unexercised portions of any options granted under this Plan which expire or
terminate or are canceled may again be subject to options under the Plan. Any
unissued shares which are not subject to an outstanding option at the
termination of this Plan shall cease to be subject to this Plan.

         2.2 Adjustment of Shares. The number of shares of stock available under
the Plan shall be decreased by the number of shares with respect to which there
are issued and outstanding options, and increased by the number of shares with
respect to which an option has expired or terminated.

                                   ARTICLE III
                                  PARTICIPATION

         3.1 Participation. The Board of Directors (the "Board") shall
determine, pursuant to Section 3.3 hereof, those employees

<PAGE>   2

who shall be eligible to receive stock options under this Plan and the number of
shares subject to each option. An option shall be granted to an employee solely
for reasons connected with his or her employment. In making its determinations,
a majority of the members of the Board acting on the matter must be
disinterested persons as provided for herein.

         3.2 Limitation for Certain Employees. No employee who owns stock
directly or within the meaning of Section 424(d) of the Code, possessing more
than Ten Percent (10%) of the total combined voting power of all classes of
stock of the Company or any parent or subsidiary corporation of the Company, may
acquire an option under this Plan. Notwithstanding the foregoing limitation,
such an employee may acquire an option if at the time the option is granted the
option price is at least One Hundred Ten Percent (110%) of the fair market value
of the stock subject to the option and such option, by its terms, is not
exercisable after the expiration of five (5) years from the date the option is
granted.

         3.3 Eligible Employees. The class of employees who are eligible to be
considered for the grant of options hereunder are any persons regularly employed
by the Company or its parent(s) or subsidiaries and are determined by the Board
to be a key employee.

                                   ARTICLE IV
                    TERMS AND CONDITIONS OF THE STOCK OPTION

         4.1 Option Price. The price at which each share of stock may be
purchased under an option (the "Option Price") shall be determined by the Board,
but shall not be less than the fair market value of the stock subject to the
option on the date the option is granted. The "fair market value" shall be
deemed for all purposes under this Plan to be the mean between the highest and
lowest sales prices reported as having occurred on the automated quotation
system operated by the National Association of Securities Dealers, Inc.
("NASDAQ"), or such other exchange where the Company's stock is traded or, if
there is no such sale on that date, then on the last preceding date on which
such a sale was reported. In no event shall the Option Price be less than the
par value of a share of common stock of the Company. In the case of an employee
described in Section 3.2, the Option Price must equal or exceed One Hundred Ten
Percent (110%) of the fair market value of the stock subject to the option and
shall not be exercisable after five (5) years from the date the option is
granted.

<PAGE>   3

         4.2 Transferability. Any option granted under this Plan shall by its
terms be nontransferable by the Optionee other than by will or the laws of
descent and distribution and is exercisable during the Optionee's lifetime only
by him or by his guardian or legal representative. Nothing shall preclude the
Optionee from designating in the instrument evidencing his option the person who
after his death may exercise the option pursuant to the Plan. If the employee
attempts to alienate, assign, hypothecate, pledge or otherwise dispose of any
option, except as herein provided, or in the event of attachment, execution or
similar process upon the rights or interest herein conferred, the option shall
become immediately null and void and without legal effect.

         4.3 Adjustments. If the outstanding shares of stock of the class then
subject to this Plan are increased or decreased, or are changed into or
exchanged for a different number or kind of shares or securities, as a result of
one or more reorganizations, recapitalizations, stock splits, reverse stock
splits, stock dividends or the like, appropriate adjustments shall be made in
the number and/or kind of shares or securities for which options may thereafter
be granted under this Plan and of which options then outstanding under this Plan
may thereafter be exercised. Any such adjustment in outstanding options shall be
made without changing the aggregate exercise price applicable to the unexercised
portions of such option.

         4.4 Maximum Option Term. No option granted under this Plan may be
exercised in whole or in part more than ten (10) years after the date of its
grant.

         4.5 Plan Duration. Options may not be granted under this Plan more than
ten (10) years after the date of the adoption of this Plan, or of shareholder
approval thereof, whichever is earlier.

         4.6 Payment. Payment for stock purchased upon any exercise of an option
granted under this Plan shall be made in full in cash or its equivalent
concurrently with such exercise, except that, if and to the extent the
instrument evidencing the option so provides, and if the Company is not then
prohibited from purchasing or acquiring shares of such stock, such payment may
be made in whole or in part with shares of the same class of stock as that which
are then subject to the option, delivered in lieu of cash concurrently with such
exercise, the shares so delivered to be valued on the basis of the fair market
value of the stock determined in

<PAGE>   4

accordance with the procedure specified in Section 4.1 hereof on the day
preceding the date of exercise.

         4.7 Limitation. Options shall not be granted under this Plan which
first become exercisable in any calendar year and which permit the Optionee to
purchase shares of the Company having an aggregate value in excess of One
Hundred Thousand Dollars ($100,000.00), determined at the time of the grant of
the option. No Optionee may exercise options during a calendar year for the
purchase of shares having an aggregate fair market value (determined at the time
of the grant of the options) exceeding One Hundred Thousand Dollars
($100,000.00), except and to the extent that such options were first exercisable
in preceding calendar years.

         4.8 Exercise of Option. The Optionee may purchase Twenty- Five Percent
(25%) of the common stock with respect to which the option has been granted on
and after the first anniversary of the date of the grant, and an additional
Twenty-Five Percent (25%) of the common stock with respect to which the option
has been granted on and after each of the three (3) succeeding anniversaries of
said date. Installments or portions thereof not exercised in earlier periods
shall be accumulated and be available for exercise in later periods. In
exercising his option, the Optionee may exercise less than the full installment
available to him, but he must exercise the option in full shares of common stock
of the Company. The Optionee is limited to ten (10) exercises during the term of
his option. The option may be exercised by paying the full amount of the Option
Price to the Company by delivery of a certified or bank cashier's check or by
delivery of shares of stock of the Company with a fair market value equal to the
Option Price as is provided for in Section 4.6. Alternatively, the Optionee may
exercise the option by paying a combination of cash or stock. Upon payment of
the Option Price, the stock so purchase shall be delivered to the Optionee;
provided, however, until the option is paid, the Optionee shall not be
considered a holder of any shares of stock purchase pursuant to this Plan. The
exercise of the option shall be subject to the following additional conditions:

                  (a) No option may be exercised within one (1) year after the
                  option is granted.

                  (b) Any option received, other than by employees described in
                  Section 3.2, must be exercised within ten (10) years after the
                  date on which the option is granted.


<PAGE>   5


                  (c) Each option may be exercised in part or in full, but must
                  be exercised in the order in which each option is granted. As
                  long as a previously issued option has not been completely
                  exercised, or has not lapsed, no subsequently issued option
                  may be exercised.

                                    ARTICLE V
                               PLAN ADMINISTRATION

         5.1 Administration. The Plan shall be administered by the Board, or by
a committee (the "Committee") of not less than three members of the Board, each
of whom shall not be eligible, and shall not have been eligible at any time
within one year prior to his appointment to the Committee for selection as a
person to whom stock may be allocated or to whom stock options may be granted
pursuant to the Plan. The interpretation and construction by the Committee of
any term or provision of the Plan or of any option granted under it shall be
final, unless otherwise determined by the Board, in which event such
determination by the Board shall be final. Notwithstanding the foregoing, this
Plan shall be administered so as to qualify the options herein granted in a
manner which will qualify the options as incentive stock options pursuant to
Section 422 of the Code. In carrying out its duties hereunder, the Board or
Committee may from time to time adopt rules and regulations for carrying out
this Plan and, subject to the provisions of this Plan, may prescribe the form or
forms of the instruments evidencing any option granted under this Plan. Subject
to the provisions of this Plan, the Board or, by delegation from the Board, the
Committee shall have full and final authority in its discretion to select the
key employees to be granted options, to grant such option and to determine the
number of shares to be subject thereto, the exercise prices, the terms of
exercise, expiration dates and other pertinent provisions thereof.

         5.2 Effective Date. The Plan shall become effective upon its adoption
by the Board, provided that the Shareholders of the Company approve the Plan by
a majority vote within twelve (12) months after the plan is adopted by the
Board. If the Plan is not approved by the shareholders within the twelve (12)
month period, all stock options granted under the Plan shall terminate at the
time of the shareholder's meeting or upon expiration of the twelve (12) month
period, whichever shall first occur.

         5.3 Plan Term. The Plan shall terminate and no further options shall be
granted after the expiration of ten (10) years

<PAGE>   6

from the date the Plan is adopted, or the Plan is approved by the shareholders,
whichever occurs earlier.

                                   ARTICLE VI
                            CORPORATE REORGANIZATIONS

         6.1 Corporate Reorganizations. Upon the dissolution or liquidation of
the Company, or upon a reorganization, merger or consolidation of the Company as
a result of which the outstanding securities of the class then subject to
options hereunder are changed into or exchanged for cash or property or
securities not of the Company's issue, or upon a sale of substantially all the
property of the Company to, or the acquisition of stock representing more than
Eighty Percent (80%) of the voting power of the stock of the Company then
outstanding by another corporation or person, the Plan shall terminate, and all
options theretofore granted hereunder shall terminate, unless provision be made
in writing in connection with such transaction for the continuance of the Plan
and/or for the assumption of options theretofore granted, or the substitution
for such options or options covering the stock of the successor employer
corporation, or a parent or a subsidiary thereof, with appropriate adjustments
as to the number and kind of shares and prices, in which event the Plan and
options theretofore granted shall continue in the manner and under the terms so
provided. If the Plan and unexercised options shall terminate pursuant to the
foregoing sentence, all persons entitled to exercise any unexercised portions of
options then outstanding, shall have the right, at such time prior to the
consummation of the transaction causing such termination as the Company shall
designate, to exercise the unexercised portions of their options, including the
portions thereof which would, but for this paragraph entitled "Corporate
Reorganizations," not yet be exercisable. The Instrument evidencing any option
may also provide for such acceleration of otherwise unexercisable portions of
the option upon other specified events or occurrences, such as involuntary
terminations of the Optionee's employment following certain changes in the
control of the Company.

                                   ARTICLE VII
                         FACTORS RELATING TO EMPLOYMENT

         7.1 Termination of Employment. If prior to the termination of the Plan,
an employee ceases to be employed other than by reason of death or disability,
each option shall be exercisable only for a period of three (3) months from the
date of the cessation of employment or the option expiration date, whichever is
earlier.

<PAGE>   7

Thereafter, all unexercised options and the rights thereunder shall terminate.

         7.2 Disability of Employee. If prior to the termination of the Plan an
employee ceases to be employed by reason of a disability as defined in Section
22(e)(3) of the Code, such employee shall exercise each option within one year
from the cessation of employment or on the option expiration date, whichever is
earlier. Thereafter, all unexercised options and the rights thereunder shall
terminate. Notwithstanding the provisions of this paragraph, however, if the
Optionee shall be discharged for cause (which shall be defined as participation
in conduct during employment consisting of fraud, felony, willful misconduct or
commission of any act which causes or may reasonably be expected to cause
substantial damage to the Company) each option to the extent not previously
exercised shall terminate at once.

         7.3 Death of Employee. If prior to the termination date of the Plan an
employee dies while holding an option, the option may be exercised to the same
extent that the Optionee could have exercised the option at the time of his
death, by the estate of the decedent or by a person who acquired the right to
exercise the option by a written designation made by the deceased employee in
the instrument in which he was granted the option, or by bequest, inheritance or
under the laws of descent and distribution of the applicable state. The option
shall be exercised within the earlier of one year after the employee's death or
upon the option expiration date.

                                  ARTICLE VIII
                                  MISCELLANEOUS

         8.1 Restricted Stock. If the instrument evidencing the option so
provides, shares of stock issued on exercise of an option granted under this
Plan may upon issuance be subject to the following restrictions (and, as used
herein, "Restricted Stock" means shares issued on exercise of options granted
under this Plan which are still subject to restrictions imposed under this
Section 8.1 that have not yet expired or terminated):

                  (a) Shares of Restricted Stock may not be sold or otherwise
                  transferred or hypothecated;

                  (b) If the employment of the holder of shares of restricted
                  stock with the Company or a subsidiary is terminated for any
                  reason other than his death, normal or

<PAGE>   8

                  early retirement in accordance with his employer's established
                  retirement policies or practices, or total disability, the
                  Company (or any subsidiary designated by it) shall have the
                  option for sixty (60) days after such termination of
                  employment to purchase for cash all or any part of his
                  restricted stock at the fair market value of the restricted
                  stock on the date of such termination of employment
                  (determined in manner and specified in the instrument
                  evidencing the option); and

                  (c) As to the shares of stock affected thereby, any additional
                  restrictions that may be imposed on particular shares of
                  restricted stock as specified in the instrument evidencing the
                  option.

         The restrictions imposed under this Section 8.1 shall apply as well to
all shares or other securities issued in respect of restricted stock in
connection with any stock split, reverse stock split, stock dividend,
recapitalization, reclassification, spin-off, split-off, merger, consolidation
or reorganization, but such restrictions shall expire or terminate at such time
or times as shall be specified therefore in the instrument evidencing the option
which provides for the restrictions.

         8.2 Amendment and Termination. The Board may alter, amend, suspend or
terminate this Plan, provided that no such action shall deprive an Optionee
without his consent or any option granted to the Optionee pursuant to this Plan
of any of his rights under such option. Except as herein provided, no such
action of the Board, unless taken with the approval of the shareholders of the
Company, may:

                  (a) increase the maximum number of shares for which options
                  granted under this Plan may be exercised;

                  (b) reduce the minimum permissible exercise price;

                  (c) alter the class of employees eligible to receive options
                  under the Plan.

         8.3 Registration of Shares. At the discretion of the Board, the options
and the shares of stock received upon exercise of an option shall be registered
with the federal Securities and Exchange Commission and any applicable state
securities law commission. In the absence of such registration, both the options
and the shares: 1) will be issued only pursuant to an exemption from
registration;

<PAGE>   9

2) cannot be sold, pledged, traded or otherwise disposed of in the absence of an
effective registration statement or an opinion of counsel satisfactory to the
Company that such registration is not required; and 3) will bear an appropriate
restrictive legend to that effect. The employees to whom options are granted may
be required to sign an investment letter satisfactory to the Board at the time
the options are exercised, and may be required to comply with any other
requirements for a "private placement" exemption under Section 4(a) of the
Securities Act of 1933 and any applicable state securities law exemption.

         8.4 Plan Does Not Confer Employment or Shareholder Rights. The right of
the Company to terminate (whether by dismissal, retirement or otherwise) the
Optionee's employment with it at any time at will, or as otherwise provided by
any agreement between the Optionee and the Company, is specifically reserved.
Neither the Optionee nor any person entitled to exercise his rights in the event
of his death shall have any rights of a shareholder with respect to the shares
subject to each option, except to the extent that a certificate for such shares
shall have been issued upon the exercise of each option as provided for herein.

Adopted this 26th day of September, 1991.


                                            DEPRENYL USA, INC.


                                            By: /s/ D. Geoffrey Shulman
                                               ---------------------------------
                                               D. GEOFFREY SHULMAN, MD, FRCDC

<PAGE>   1
                                                                    Exhibit  4.2

                           DUSA PHARMACEUTICALS, INC.

                        1994 RESTRICTED STOCK OPTION PLAN


                               ARTICLE I - PURPOSE

         This non-qualified restricted stock option plan (the "Plan") is
intended to advance the interests of DUSA Pharmaceuticals, Inc. (the "Company")
and its shareholders by encouraging and enabling selected officers, directors,
employees and consultants of the Company, upon whose judgment, initiative and
effort the Company is largely dependent for the successful conduct of its
business, to acquire and retain a proprietary interest in the Company by
ownership of its common stock. Options granted under the Plan are not intended
to be options which meet the requirements of Section 422 of the Internal Revenue
Code of 1986, as amended (the "Code").

                            ARTICLE II - DEFINITIONS

         (a) "Board of Directors" shall mean the board of directors of the
Company.

         (b) "Common Stock" shall mean the Company's no par value common stock.

         (c) "Date of Grant" shall mean the date on which an option is granted
under the Plan.

         (d) "Option" shall mean the option granted under the Plan.

         (e) "Optioned Shares" shall mean that number of Common Stock shares
which are subject to the Option granted by the Company to the optionee pursuant
to this Agreement.

         (f) "Optionee" shall mean a person to whom an Option has been granted
under the Plan; and

         (g) "Successor" shall mean the legal representative of the estate of
the deceased Optionee, or the person or persons who acquire the right to
exercise an Option by bequest or inheritance or by reason of the death of an
Optionee.

                    ARTICLE III - ADMINISTRATION OF THE PLAN

         (a) Administration. The Plan shall be administered by the Board of
Directors or a committee of not less than two (2) members of the Board of
Directors (the "Committee"). If the Plan is administered by the Committee, it
shall report all action taken by it to the Board of Directors. The Board of
Directors or the Committee shall have complete authority and discretion to
interpret and


<PAGE>   2

administer the Plan in a manner which is consistent with the Plan's provisions,
and to make any amendments with respect thereto, subject to Article VIII,
subparagraph (c). However, in no event shall the Board of Directors or the
Committee have the power to determine eligibility of directors to participate in
the Plan, or to determine the number, the value, the vesting or exercise period
or the timing of the option grants to be made under the Plan to directors (all
such determinations are automatic pursuant to the provisions of the Plan). Any
action taken by the Board of Directors or the Committee with respect to the
administration of the Plan which would violate Rule 16b-3 under the Securities
Exchange Act of 1934, as amended from time to time (or any successor provision)
shall be null and void. The decisions made by the Board of Directors or the
Committee in connection with selecting persons to participate (other than
directors), authorizing the number of stock options and any other aspect of the
Plan administration shall be final and binding.

         (b) Effective Date. The Plan shall become effective upon its adoption
by the Board (the "Approval Date"), provided that the shareholders of the
Company approve the Plan by a majority vote at the next annual shareholder
meeting. If the Plan is not approved by the shareholders, all Options granted
under the Plan shall terminate.

         (c) Plan Term. The Plan shall terminate and no further Options shall be
granted after the expiration of ten (10) years from the date the Plan is
adopted.

                  ARTICLE IV - COMMON STOCK SUBJECT TO THE PLAN

         The maximum number of shares of the Company's Common Stock which may be
issued upon the exercise of Options granted under the Plan shall not exceed
three hundred thousand (300,000), subject to adjustment under the provisions of
Article VII hereof.

                            ARTICLE V - PARTICIPANTS

         Options may be granted under the Plan to any person who is or who
agrees to become an officer, director, employee or consultant of the Company or
its subsidiaries, provided that the number of shares reserved for issuance under
the Plan to any one person pursuant to options granted shall not exceed 5% of
the Company's outstanding Common Stock.

              ARTICLE VI - AUTOMATIC GRANTS OF OPTIONS TO DIRECTORS


                                       2
<PAGE>   3


         Incumbent directors shall receive automatic grants of 10,000 options to
purchase the Company's Common Stock on each anniversary of the Approval Date.
Incoming directors shall receive 15,000 options to purchase the Company's Common
Stock on the first Approval date after their election to the Board of Directors
and thereafter, shall receive the option amounts designated for incumbent
directors. The specific terms and conditions of such option grants shall be
consistent with Article VII.

                ARTICLE VII - TERMS AND CONDITIONS OF THE OPTIONS

         Any Option granted under the Plan shall be evidenced by an agreement
executed by the Company and the Optionee, and shall contain such terms and be in
such form as the Board of Directors or the Committee, from time to time,
approve, subject to the following limitations and conditions:

         (a) Option Price. The price at which each share of stock may be
purchased under an Option (the "Option Price") shall be determined by the Board
of Directors or by the Committee, but shall not be less than the fair market
value of a share of Common Stock on the day immediately preceding the Date of
Grant. The "fair market value" shall be deemed for all purposes under the Plan
to be the closing sales price reported as having occurred on the automated
quotation system operated by the National Association of Securities Dealers,
Inc. ("NASDAQ") or such other exchange where the Company's stock is traded
(e.g., The Toronto Stock Exchange) or, if there is not such sale on that date,
then on the last preceding date on which such a sale was reported.

         If at any time the Common Stock is not listed on any securities
exchange or quoted in the NASDAQ system, the Option Price will be the fair
market value of the Common Stock as determined in the good faith judgment of the
Board of Directors.

         (b) Period of Option. The expiration date of each Option shall be ten
(10) years from the Date of Grant, provided that if such day is not a day on
which the Company is open for business, then on the first following day on which
the Company is open for business.

         (c) Exercise of Option. The Optionee may purchase twenty-five percent
(25%) of the Common Stock with respect to which the Option has been granted on
or after the first anniversary of the day immediately preceding the Date of
Grant and an additional twenty-five percent (25%) of the Common Stock with
respect to which the Option has been granted on and after each of the three
succeeding anniversaries of the day immediately preceding the Date of Grant.
Installments or portions thereof not exercised in earlier periods shall be
accumulated and available for exercise in


                                       3
<PAGE>   4

later periods. In exercising the Option, the Optionee may exercise less than the
full installment available to him, but he/she must exercise the Option in full
shares of Common Stock of the Company. The Optionee is limited to ten (10)
exercises during the term of his/her Option. The Option may be exercised by
giving to the Company, at its registered office, notice in writing setting out
the number of Optioned Shares with respect to which the option is being
exercised. The notice must be accompanied by a certified check, official bank
cashier's check or money order in an amount equal to the Option Price multiplied
by the number of Optioned Shares requested and a duly executed copy of the
Restricted Stock Option Agreement given to the Optionee. Until the exercised
Optioned Shares are paid in full, the Optionee shall not be considered a holder
of any shares of the Common Stock purchased pursuant to the Plan.

         (d) Vesting of Shareholders Rights. No Optionee nor his/her successor
shall have any rights as a shareholder of the Company until the certificates
evidencing shares purchased are properly delivered to such Optionee or his/her
successor against payment for the shares being purchased.

         (e) Non-Transferability of Option. No Option shall be transferable or
assignable by an Optionee other than by will or by the laws of descent and
distribution, and each Option shall be exercisable during the Optionee's
lifetime only by him. Nothing shall preclude the Optionee from designating in
the instrument evidencing his Option the person who after his death may exercise
the Option pursuant to the Plan. No Option shall be subject to execution,
attachment or similar process. Upon any attempt to assign, transfer, pledge,
hypothecate or otherwise dispose of this Option contrary to the provisions
hereof, or upon the levy of any attachment or similar process upon the Option
granted herein, such Option shall immediately become void.

         (f) Termination of Employment. Subject to subparagraph (g) of this
Article V, upon termination of an Optionee's employment with or service to the
Company for any reason, such part of the Option as is then exercisable but
unexercised may be exercised by the Optionee for a period of ninety (90) days
after termination or such later date as the Board of Directors may approve after
which time the Option shall expire; provided, however, that in no event may the
Option be exercised after the expiration date of the Option. The granting of an
Option to an Optionee does not alter, in any way, the Company's existing rights
to terminate such Optionee's employment or service at any time, for any reason,
nor does it confer upon such Optionee any rights or privileges, except as
specifically provided for him/her under the Plan.

         (g) Death or Permanent Disability of Optionee. If the Optionee dies or
becomes totally


                                       4
<PAGE>   5

and permanently disabled while in the employ or service of the Company, such
part of the Option as is then exercisable but unexercised may be exercised by
the Optionee or his/her successor for a period of six (6) months after the death
or disability of the Optionee (notwithstanding the expiration date of the
Option). The Board of Directors shall be entitled to determine if and when an
Optionee has become permanently disabled. In the event that the Option is not
exercised within the six (6) month period, the Option shall expire.

                           ARTICLE VIII - ADJUSTMENTS

         (a) Adjustment of Shares Subject to the Plan. The number of shares of
stock available under the Plan shall be decreased by the number of shares with
respect to which there are issued and outstanding Options, and increased by the
number of shares with respect to which an Option has expired, terminated or been
canceled.

         (b) Adjustment of Options Granted. In the event that the outstanding
shares of Common Stock of the Company are hereafter increased or decreased, or
changed into or exchanged for a different number or kind of shares or other
securities of the Company, or for another corporation, by reason of a
recapitalization, reclassification, stock split, reverse stock split,
combination of shares or dividend or any other distribution payable in capital
stock, appropriate adjustments shall be made by the Board of Directors or the
Committee in the number and kind of shares for the purchase of which Options may
be granted under the Plan. In addition, the Board of Directors or the Committee
shall make appropriate adjustments in the number and kind of shares as to which
outstanding Options, or portions thereof, then unexercised, shall be exercisable
to the end that the proportionate interest of the holder of the Option shall, to
the extent practicable, be maintained without change in the total price
applicable to the unexercised portion of the Option, but with a corresponding
adjustment in the Option Price per share.

         (c) Dissolution or Liquidation. In the event of the dissolution or
liquidation of the Company, any Option granted under the Plan shall terminate as
of the date to be fixed by the Board of Directors or the Committee, provided
that not less than thirty (30) days written notice of the date so fixed shall be
given to each Optionee and each such Optionee shall have the right during such
period to exercise his/her Option as to all or any part of the shares covered
thereby, including shares as to which this Option would not otherwise be
exercisable by reason of an insufficient lapse of time.

         (d) Reorganization. In the event of a Reorganization (as hereinafter
defined) in which


                                       5
<PAGE>   6

the Company is not the surviving or acquiring company, or in which the Company
is or becomes a wholly-owned subsidiary of another company after the effective
date of the Reorganization, then

                  (i) if there is no plan or agreement respecting the
         Reorganization (the "Reorganization Agreement") or if the
         Reorganization Agreement does not specifically provide for the change,
         conversion or exchange of the shares under outstanding and unexercised
         stock options for securities of another corporation, then the Board of
         Directors or the Committee shall take the Option, and the Option shall
         terminate, as provided in subparagraph (c) of this Article VII; or

                  (ii) if there is a Reorganization Agreement and if the
         Reorganization Agreement specifically provides for the change,
         conversion or exchange of the shares under outstanding and unexercised
         stock option for securities of another corporation, then the Board of
         Directors or the Committee shall adjust the shares under such
         outstanding and unexercised stock options (and shall adjust the shares
         remaining under the Plan, if the Reorganization Agreement makes
         specific provision therefor) in a manner not inconsistent with the
         provisions of the Reorganization Agreement for the adjustment, change,
         conversion or exchange of such stock and such Options.

         The term "Reorganization" as used in this subparagraph (d) of this
Article VII, shall mean any statutory merger, statutory consolidation, sale of
all or substantially all of the assets of the Company, or sale, pursuant to an
agreement with the Company, of securities of the Company, pursuant to which the
Company is or becomes a wholly-owned subsidiary of another company after the
effective date of the Reorganization.

                           ARTICLE IX - MISCELLANEOUS

         (a) Restrictions on Common Stock. Common Stock acquired pursuant to the
exercise of an Option under the Plan shall be subject to applicable transfer
restrictions under applicable Canadian or United States federal securities laws,
under the requirements of any national securities exchange or market upon which
such common stock are then listed and/or traded, and under any blue sky or state
securities laws applicable to such common stock. If the instrument evidencing
the Option so provides, Common Stock issued on exercise of an Option granted
under the Plan may upon issuance be subject to additional restrictions.

         (b) Registration of Shares. At the discretion of the Board of
Directors, the Options and the shares of Common Stock received upon exercise of
an Option shall be registered with the United


                                       6
<PAGE>   7

States Securities and Exchange Commission and any applicable state securities
law commission. In the absence of such registration, both the Options and the
Optioned Shares: 1) will be issued only pursuant to an exemption from
registration; 2) cannot be sold, pledged, traded or otherwise disposed of in the
absence of an effective registration statement or an opinion of counsel
satisfactory to the Company that such registration is not required; 3) will bear
an appropriate restrictive legend to that effect. The Optionees may be required
to sign an investment letter satisfactory to the Board of Directors at the time
the Options are exercised, and may be required to comply with any other
requirements for an exemption under the Securities Act of 1933 and any
applicable state securities law exemption.

         (c) Amendment, Suspension and Termination of the Plan. The Board of
Directors may, at any time, suspend or terminate the Plan or may amend it,
subject to the consent of The Toronto Stock Exchange, from time to time in such
respects as the Board of Directors may deem advisable in order that the Options
granted thereunder may conform to any changes in the law or in any other respect
which the Board of Directors may deem to be in the best interests of the
Company. Unless the Plan shall theretofore have been terminated by the Board of
Directors, the Plan shall terminate ten (10) years after the effective date of
the Plan. No Option may be granted during any suspension or after the
termination of the Plan. No amendment, suspension or termination of the Plan
shall, without an Optionee's consent, alter or impair any of the rights or
obligations under any Option theretofore granted to such Optionee under the
Plan. Except as herein provided, no such action of the Board of Directors,
unless taken with the approval of the shareholders of the Company, may:

                  (i) increase the maximum number of shares for which Options
         granted under the Plan may be exercised;

                  (ii) reduce the minimum permissible Option Price; or

                  (iii) alter the class of participants eligible to receive
         Options under the Plan.

         (d) Use of Proceeds. The proceeds received by the Company from the sale
of Common Stock, pursuant to the exercise of Options granted under the Plan,
shall be added to the Company's general funds and used for general corporate
purposes.

         Adopted this 2nd day of August, 1994.


                                       7

<PAGE>   1
                                                                     EXHIBIT 4.3

                           DUSA PHARMACEUTICALS, INC.

                                1996 OMNIBUS PLAN
                           (AS AMENDED JUNE 10, 1998)


                               ARTICLE I - PURPOSE

         This Omnibus Plan (the "Plan") is intended to promote the growth and
general prosperity of DUSA Pharmaceuticals, Inc. (the "Company") and its
shareholders by offering incentives to its key directors, employees and
consultants of the Company who are primarily responsible for the growth of the
Company and to attract and retain qualified directors, employees and consultants
of the Company and thereby benefit its shareholders based on the growth of the
Company.

                            ARTICLE II - DEFINITIONS

         Unless the context indicates otherwise, the following terms, when used
in this Plan, shall have the meanings set forth in this Section:

         (a) "Award" shall mean grants under this Plan that provide the
participants with the right to purchase Common Stock or that are valued by
reference to the Fair Market Value of the Common Stock.

         (b) "Board" shall mean the Board of Directors of the Company.

         (c) "Cause" shall mean deliberate, willful or gross misconduct.

         (d) A "Change of Control" shall be deemed to have taken place upon (i)
the acquisition by a third person, including a "group" as defined in Section
13(d)(3) of the Securities Exchange Act of 1934, as amended, of shares of the
Company having 50% or more of the total number of votes that may be cast for the
election of Directors of the Company; (ii) shareholder approval of a transaction
for the acquisition of the Company, or substantially all of its assets by
another entity or for a merger, reorganization, consolidation or other business
combination to which the Company is a part; or (iii) the election during any
period of 24 months or less of 50% or more of the Directors of the Company where
such Directors were not in office immediately prior to such period provided,
however, that no "Change of Control" shall be deemed to have taken place if the
Directors of the Company in office on the date of adoption of the Plan, or their
successors in office nominated by such Directors, affirmatively approve a
resolution to such effect.

         (e) "Code" shall mean the Internal Revenue Code of 1986 as it may be
amended from time to time.

         (f) "Committee" shall mean, collectively, the Board, or any Committee
of two or more Non-Employee Directors, that may be designated by the Board to
administer the Plan.

         (g) "Common Stock" shall mean all classes of stock, without par value,
including convertible preferred, stock purchase warrants and all common stock
equivalents.

         (h) "Consultant" shall mean any person who (i) is engaged to perform
services for the Company or its Subsidiaries, other than as an Employee or
Director, or (ii) has agreed to become a consultant within the meaning of clause
(i).

         (i) "Director" shall mean any member of the Board.


<PAGE>   2

         (j) "Disability" shall mean inability to perform the services required
hereunder due to mental or physical disability which continues for either (i) a
total of 180 working days during any 12- month period or (ii) 150 consecutive
working days.

         (k) "Employee" shall mean (i) any full-time employee of the Company or
its Subsidiaries (including Directors who are otherwise employed on a full-time
basis by the Company or its Subsidiaries), or (ii) any person who has agreed to
become an employee within the meaning of clause (i).

         (l) "Exchange Act" shall mean the Securities Exchange Act of 1934 as it
may be amended from time to time.

         (m) "Fair Market Value" of the Common Stock on a given date shall be
based upon, the last sales price or, if unavailable, the average of the closing
bid and asked prices per share of the Common Stock on such date (or, if there
was no trading or quotation in the Common Stock on such date, on the next
preceding date on which there was trading or quotation).

         (n) "Grantee" shall mean a person granted an Award under the Plan.

         (o) "ISO" shall mean an Option granted pursuant to the Plan to purchase
shares of the Common Stock and intended to qualify as an incentive stock option
under Section 422 of the Code, as now or hereafter constituted.

         (p) "1933 Act" shall mean the Securities Act of 1933; as amended.

         (q) "Non-Employee Director" shall mean a non-employee director as
defined in Exchange Act Rule 16b-3(b)(3)(i).

         (r) "NQSO" shall mean an Option granted pursuant to the Plan to
purchase shares of the Common Stock that is not an ISO.

         (s) "Options" shall refer collectively to NQSOs and ISOs issued under
and subject to the Plan. Each option is exercisable into one share of Common
Stock of the Company.

         (t) "Parent" shall mean any parent corporation as defined in Section
424 of the Code.

         (u) "Performance Awards" shall mean grants under the Plan, payable in
cash, Common Stock, other securities or other awards and shall confer on the
holder there of the right to receive payments, upon the achievement of such
performance goals during such performance periods as the Committee shall
establish.

         (v) "Restricted Stock" shall mean Common Stock subject to restrictions
on transfer and/or such other restrictions on incidents of ownership as the
Committee may determine.

         (w) "SAR" shall mean a right to receive, upon surrender of the right,
but without payment, an amount payable in cash.

         (x) "Subsidiary" shall mean (i) any corporation with respect to which
the Company owns, directly or indirectly, 50% or more of the total combined
voting power of all classes of stock of such Company, or (ii) any entity which
the Committee reasonably expects to become a subsidiary within the meaning of
clause (i).

                          ARTICLE III - ADMINISTRATION

         The Plan shall be administered by the Committee. Subject to the
provisions of the Plan, the Committee shall have full discretion and the
exclusive power (i) to select the Employees, Consultants and Directors who will
participate in the Plan and to make Awards to such Employees, Consultants, and
Directors, (ii) to determine the time at which such Awards shall be granted and
any terms and conditions with respect to such Awards as shall not be
inconsistent with the

<PAGE>   3

provisions of the Plan, and (iii) to resolve all questions relating to the
administration of the Plan. The interpretation of and application by the
Committee of any provision of the Plan shall be final and conclusive. The
Committee may in its discretion establish such rules and guidelines relating to
the Plan as it may deem desirable. No member of the Board of Directors or the
Committee shall be liable for any action or determination made in good faith
with respect to the Plan or any Awards granted hereunder. The Committee may
employ such legal counsel, consultants and agents as it may deem desirable for
the administration of the Plan and may rely upon any opinion received from any
such counsel or consultant and any computation received from any such consultant
or agent. The Committee shall keep minutes of its actions under the Plan.

             ARTICLE IV - SHARES OF COMMON STOCK SUBJECT TO THE PLAN

         Subject to the provisions of Article XV, the maximum number of shares
with respect to which the Awards may be granted under the Plan shall not exceed
fifteen percent (15%) of the number of shares of Common Stock outstanding. Any
shares subject to an Award under the Plan, which Award for any reason expires or
is terminated unexercised as to such shares, shall again be available for the
grant of other Awards under the Plan provided, however, that forfeited Common
Stock or other securities shall not be available for further Awards if the
participant has realized any benefits of ownership from such Common Stock.
Shares delivered upon exercise of the Awards, at the election of the Board of
Directors of the Company, may be stock that is authorized but previously
unissued or stock reacquired by the Company or both.

                             ARTICLE V - ELIGIBILITY

         The individuals who shall be eligible to participate in the Plan shall
be Employees, Consultants and Directors of the Company. An Employee, Consultant
or Director who has been granted an Award in one year shall not necessarily be
entitled to be granted Awards in subsequent years.

        ARTICLE VI - GRANTS OF STOCK OPTIONS TO EMPLOYEES AND CONSULTANTS

         The Committee may grant Options, as follows, which may be designated as
(i) NQSOs or (ii) ISOs intended to qualify under Code Section 422:

         (a) NONQUALIFIED STOCK OPTIONS. A NQSO is a right to purchase a
specified number of shares of Common Stock during such specified time as the
Committee may determine, not to exceed ten (10) years, at a price determined by
the Committee that, unless deemed otherwise by the Committee, is not less than
the Fair Market Value of the Common Stock on the date the option is granted.
NQSOs granted to Employees and Consultants shall vest at the rate of one quarter
of the total granted on each of the first, second, third and fourth
anniversaries of the day of the grant, subject to satisfaction of certain
conditions involving continuous periods of service or engagement.

                  (i) The purchase price of the Common Stock subject to the NQSO
may be paid in cash. At the discretion of the Committee, the purchase price may
also be paid by the tender of Common Stock or through a combination of Common
Stock and cash or through such other means as the Committee determines are
consistent with the Plan's purpose and applicable law. No fractional shares of
Common Stock will be issued or accepted.

                  (ii) Without limiting the foregoing, to the extent permitted
by law (including relevant state law), (A) the Committee may agree to accept, as
full or partial payment of the purchase price of Common Stock issued upon the
exercise of the NQSO, a promissory note of the person exercising the NQSO
evidencing the person's obligation to make future cash payments to the Company,
which promissory note shall be payable as determined by the Company (but in no
event later than five (5) years after the date thereof), shall be secured by a
pledge of the shares of Common Stock purchased and shall bear interest at a rate
established by the Committee and (B) the Committee may also permit the person
exercising the NQSO, either on a selective or aggregate basis, to simultaneously
exercise the NQSO and sell

<PAGE>   4

the shares of Common Stock acquired, pursuant to a brokerage or similar
arrangement approved in advance by the Committee, and use the proceeds from sale
as payment of the purchase price of such Common Stock.

         (b) INCENTIVE STOCK OPTIONS. An ISO is an Award in the form of an
Option to purchase Common Stock that complies with the requirements of Code
Section 422 or any successor section.

                  (i) The aggregate Fair Market Value (determined at the time of
the grant of the Award) of the shares of Common Stock subject to ISOs which are
exercisable by one person for the first time during a particular calendar year
shall not exceed $100,000. To the extent that ISOs granted to an employee exceed
the limitation set forth in the preceding sentence, ISOs granted last shall be
treated as NQSOs.

                  (ii) No ISO may be granted under this Plan on or after the
tenth anniversary of the date this Plan is adopted or the date this Plan is
approved by shareholders, whichever is earlier.

                  (iii) No ISO may be exercisable more than:

                           (A) in the case of an Employee who is not a Ten
Percent Shareholder, within the meaning of Code Section 422, on the date the ISO
is granted; ten (10) years after the date the ISO is granted; and

                           (B) in the case of an Employee who is a Ten Percent
Shareholder, within the meaning of Code Section 422, on the date the ISO is
granted, five (5) years after the date the ISO is granted.

                  (iv) The exercise price of any ISO shall be determined by the
Committee and shall be no less than:

                           (A) in the case of an Employee who is not a Ten
Percent Shareholder, on the date the ISO is granted, the Fair Market Value of
the Common Stock subject to the ISO on such date; and

                           (B) in the case of an Employee who is a Ten Percent
Shareholder, on the date the ISO is granted, not less than 110 percent of the
Fair Market Value of the Common Stock subject to the ISO on such date.

                  (v) The Committee may provide that the option price under an
ISO may be paid by one or more of the methods available for paying the option
price of an NQSO.

                  (vi) ISOs shall vest at the rate of one quarter of the total
granted on each of the first, second, third and fourth anniversaries of the day
of the grant, subject to satisfaction of certain conditions involving continuous
periods of service or engagement.

 ARTICLE VII - GRANTS OF STOCK APPRECIATION RIGHTS TO EMPLOYEES AND CONSULTANTS

         An SAR is a right to receive, upon surrender of the right, but without
payment, an amount payable in cash.

         (i) The amount payable with respect to each SAR shall be equal in value
to the applicable percentage of the excess, if any, of the Fair Market Value of
a share of Common Stock on the exercise date over the exercise price of the SAR.
The exercise price of the SAR shall be determined by the Committee and shall not
be less than the Fair Market Value of a share of Common Stock on the date the
SAR is granted.

         (ii) In the case of an SAR granted in tandem with an ISO to an Employee
or Consultant who is a Ten Percent Shareholder on the date of such grant, the
amount payable with respect to each SAR shall be equal in value to the
applicable percentage of the excess, if any, of the Fair Market Value of a share
of Common Stock on the exercise date over the exercise price of the SAR, which
exercise price shall not be less than 110% of the Fair Market Value of a share
of Common Stock on the date the SAR is granted.

         (iii) The applicable percentage and exercise price shall be established
by the Committee at the time the SAR is granted.


<PAGE>   5


         (iv) SARs shall vest at the rate of one quarter of the total granted on
each of the first, second, third and fourth anniversaries of the day of the
grant, subject to satisfaction of certain conditions involving continuous
periods of service or engagement.

     ARTICLE VIII - GRANTS OF RESTRICTED STOCK TO EMPLOYEES AND CONSULTANTS

         Restricted Stock is Common Stock of the Company that is issued to a
participant at a price determined by the Committee, which price may be zero, and
is subject to restrictions on transfer and/or such other restrictions on
incidents of ownership as the Committee may determine.

     ARTICLE IX - GRANTS OF PERFORMANCE AWARDS TO EMPLOYEES AND CONSULTANTS

         A Performance Award granted under the Plan (i) may be denominated or
payable in cash, Common Stock (including without limitation, Restricted Stock),
other securities or other Awards and (ii) shall confer on the holder thereof the
right to receive payments, in whole or in part, upon the achievement of such
performance goals during such performance periods as the Committee shall
establish. Subject to the terms of the Plan and any applicable Award agreement,
the performance goals to be achieved during any performance period, the length
of any performance period, the amount of any Performance Award granted and the
amount of any payment or transfer to be made pursuant to any Performance Award
shall be determined by the Committee.

           ARTICLE X - GRANTS OF OTHER STOCK-BASED INCENTIVE AWARDS TO
                           EMPLOYEES AND CONSULTANTS

         The Committee may from time to time grant Awards under this Plan that
provide the participant with the right to purchase Common Stock or that are
valued by reference to the Fair Market Value of the Common Stock (including, but
not limited to, phantom securities or dividend equivalents). Such Awards shall
be in a form determined by the Committee (and may include terms contingent upon
a change of control of the Company), provided that such Awards shall not be
inconsistent with the terms and purposes of the Plan. The Committee will
determine the price of any Award and may accept any lawful consideration.

                ARTICLE XI - GRANTS OF STOCK OPTIONS TO DIRECTORS

         (a) Directors of the Company shall be eligible to receive NQSOs under
the Plan. Each individual who agrees to become a Director shall receive, without
the exercise of the discretion of any person, a NQSO under the Plan relating to
the purchase of 15,000 shares of Common Stock at an exercise price equal to the
Fair Market Value. Thereafter, on the day after the annual meeting of
shareholders, each person who is a continuing Director on any such date shall
receive, without the exercise of the discretion of any person, a NQSO under the
Plan relating to the purchase of 10,000 shares of Common Stock.

         (b) The exercise price of each share of Common Stock subject to a NQSO
granted to a Director shall equal the Fair Market Value of a share of Common
Stock on the date such NQSO is granted. The option price of a NQSO granted to a
Director may be paid in accordance with Article VI (a) (i) and (ii) of the Plan.

         (c) Each automatic NQSO granted to a Director shall vest in full on the
date of the grant. The NQSOs to directors shall have a term not to exceed ten
(10) years from the date of grant, or, if later, the date the Grantee becomes a
Director. Notwithstanding the exercise period of any NQSO granted to a Director,
all such NQSOs shall immediately become exercisable upon (i) the death of a
Director while serving as such, or (ii) a Change of Control.


<PAGE>   6


                        ARTICLE XII - EXERCISE OF OPTIONS

         Options granted under the Plan may be exercised by a Grantee only while
the Employee, Consultant or Director is and, continuously since the date the
Option was granted, has been an Employee, Consultant or Director of the Company
or one of its subsidiaries, except that:

         (i) if the Grantee's termination of employment is other than for Cause,
any Options held by the Grantee may be exercised, to the extent then
exercisable, for a period of three months after the date of such termination of
employment;

         (ii) if such termination of employment is by reason of retirement or
disability, any Options held by the Grantee at the time of death or disability
will be exercisable for a period of 12 months after the date of such termination
of employment;

         (iii) in the event of death after termination of employment pursuant to
(i) or (ii) above, the person or persons to whom the Grantee's rights are
transferred by will or the laws of descent and distribution shall have a period
of three years from the date of termination of the Grantee's employment to
exercise any Options which the Grantee could have exercised during such period;
and

         (iv) in the event of the death of an Grantee while employed, any
Options then held by the Grantee shall become fully and immediately exercisable
and may be exercised by the person or persons to whom the Grantee's rights are
transferred by will or the laws of descent and distribution for a period of
three years after the Grantee's death. In no event, however, shall any Option be
exercisable after the date specified in Article VI, as applicable.

         An Option granted hereunder shall be exercisable, in whole or in part,
only by written notice delivered in person or by mail to the Secretary of the
Company at its principal office, specifying the number of shares of Common Stock
to be purchased and accompanied by payment thereof and otherwise in accordance
with the option agreement pursuant to which the Option was granted.

         In the event of a Change of Control affecting the Company, then,
notwithstanding any provision of the Plan or of any provisions of any Award
agreements entered into between the Company and any participant to the contrary,
all Awards that have not expired and which are then held by any participant (or
the person or persons to whom any deceased participant's rights have been
transferred) shall, as of such Change of Control, become fully and immediately
vested and exercisable and may be exercised for the remaining term of such
Awards.

                         ARTICLE XIII - AWARD AGREEMENTS

         Each Award granted under the Plan shall be evidenced by an Award
agreement between the Grantee and the Company, setting forth the number of
shares of Common Stock, SARs, or units subject to the Award and such other terms
and conditions applicable to the Award not inconsistent with the Plan as the
Committee may deem appropriate.

                          ARTICLE XIV - TAX WITHHOLDING

         The Committee may establish such rules and procedures as it considers
desirable in order to satisfy any obligation of the Company or any subsidiary to
withhold federal income taxes or other taxes with respect to any Award made
under the Plan. Such rules and procedures may provide (i) in the case of Awards
paid in shares of Common Stock, that the person receiving the Award may satisfy
the withholding obligation by instructing the Company to withhold shares of
Common Stock otherwise issuable upon exercise of such Award in order to satisfy
such withholding obligation and (ii) in the case of an Award paid in cash, that
the withholding obligation shall be satisfied by withholding the applicable
amount and paying the net amount in cash to the participant.


<PAGE>   7


                    ARTICLE XV - DILUTION OR OTHER ADJUSTMENT

         If the Company is a party to any merger or consolidation, or undergoes
any separation, reorganization or liquidation, the Board of Directors of the
Company shall have the power to make arrangements, which shall be binding upon
the holders of unexpired Awards, for the substitution of new Awards for, or the
assumption by another corporation of, any unexpired Awards then outstanding
hereunder. In the case of any ISO, such action shall be taken only in the manner
and to the extent permitted by Sections 422 and 424 of the Code. In addition, in
the event of a reclassification, stock split, combination of shares, separation
(including a spin-off), dividend on shares of the Common Stock payable in stock,
or other similar change in capitalization or in the corporate structure of
shares of the Common Stock of the Company, the Committee shall conclusively
determine the appropriate adjustment in the option prices of outstanding
Options, in the number and kind of shares or other securities as to which
outstanding Awards shall be exercisable, and in the aggregate number of shares
with respect to which Awards may be granted. In the case of any ISO, any such
adjustment in the shares or other securities subject to the ISO (including any
adjustment in the Option price) shall be made in such manner as not to
constitute a modification as defined by Section 424(h)(3) of the Code and only
to the extent permitted by Sections 422 and 424 of the Code.

                           ARTICLE XVI - ASSIGNABILITY

         No Award granted under this Plan shall be sold, pledged, assigned or
transferred other than by will or the laws of descent and distribution, and
Awards shall be exercisable during the Grantee's lifetime only by the Grantee.

                     ARTICLE XVII - AMENDMENT OR TERMINATION

         The Board of Directors of the Company may at any time amend, suspend or
terminate the Plan subject to the regulatory requirements of the United States
Securities and Exchange Commission and the National Association of Securities
Dealers or other applicable federal or state regulatory authority, provided,
however, that no change in any Awards previously granted may be made without the
consent of the holder thereof.

                       ARTICLE XVIII - GENERAL PROVISIONS

         (a) Common Stock acquired pursuant to the exercise of an Option under
the Plan shall be subject to applicable transfer restrictions under applicable
Canadian or United States federal securities laws, under the requirements of any
national securities exchange or market upon which such Common Stock are then
listed and/or traded, and under any blue sky or state securities laws applicable
to such Common Stock. If the instrument evidencing the Option so provides,
Common Stock issued on exercise of an Option granted under the Plan may upon
issuance be subject to additional restrictions.

         (b) At the discretion of the Board of Directors, the Options and the
shares of Common Stock received upon exercise of an Option shall be registered
with the United States Securities and Exchange Commission and any applicable
state securities law commission. In the absence of such registration, both the
Options and the shares of Common Stock underlying the Options: 1) will be issued
only pursuant to an exemption from registration; 2) cannot be sold, pledged,
traded or otherwise disposed of in the absence of an effective registration
statement or an opinion of counsel satisfactory to the Company that such
registration is not required; 3) will bear an appropriate restrictive legend to
that effect. Individuals receiving Options may be required to sign an investment
letter satisfactory to the Board of Directors at the time the Options are
exercised, and may be required to comply with any other requirements for an
exemption under the Securities Act of 1933 and any applicable state securities
law exemption.

         (c) The proceeds received by the Company from the sale of Common Stock,
pursuant to the exercise of Options granted under the Plan, shall be added to
the Company's general funds and used for general corporate purposes.


<PAGE>   8


         (d) No Awards may be exercised by the holder thereof if such exercise,
and the receipt of cash or stock thereunder, would be, in the opinion of counsel
selected by the Company, contrary to law or the regulations of any duly
constituted authority having jurisdiction over the Plan.

         (e) No Award recipient shall have any rights as a shareholder with
respect to any shares subject to Awards granted to him or her under the Plan
prior to the date as of which he or she is actually recorded as the holder of
such shares upon the stock records of the Company.

         (f) Nothing contained in the Plan or in Awards granted thereunder shall
confer upon any Employee, Consultant or Director any right to continue in the
employ of the Company or any of its subsidiaries or interfere in any way with
the right of the Company or any of its subsidiaries to terminate his or her
employment at any time.

                          ARTICLE XIX - EFFECTIVE DATE

         The Plan shall become effective on the date of its adoption by the
Board of Directors of the Company subject to approval of the Plan by the holders
of a majority of the outstanding voting shares of the Company within 12 months
after the date of the Plan's adoption by said Board of Directors. In the event
of the failure to obtain such shareholder approval, the Plan shall be null and
void and the Company shall have no liability thereunder. No Award granted under
the Plan shall be exercisable until such shareholder approval has been obtained.

                            ARTICLE XX - TERMINATION

         No Award may be granted under the Plan on or after the date which is
ten years following the effective date specified in Article XIX, but Awards
previously granted may be exercised in accordance with their terms.

Adopted the 10th day of June, 1998

<PAGE>   1
                                                                  Exhibit 4.4(a)


                             STOCK OPTION AGREEMENT

         THIS AGREEMENT is made as of the 30th day of September, 1991 between
DEPRENYL USA, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and D. GEOFFREY SHULMAN,
MD, FRCPC, an individual residing at 256 Russell Hill Road, Toronto, Ontario M4V
2T2, CANADA (hereinafter referred to as the "Participant").

         WITNESSETH:

         WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant an option to him to
purchase shares of the Company's common stock ("Shares") on the terms and
conditions set forth in this Agreement.

         NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:

1.1      DEFINITIONS

         In this Agreement:

         "Board of Directors" means the board of directors of the Company;

         "Exercise Price" means CDN. $6.79;

         "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later
         of the dates provided in Section 2.2;

         "Optioned Shares" means that number of Shares which are subject to the
         option granted by the Company to the Participant pursuant to this
         Agreement; and

         "Shares" means shares of common stock, without par value, of the
         Company.

2.1      GRANT OF OPTION

         The Company hereby grants to the Participant an option to purchase, in
         accordance with the vesting rights outlined in Sections 2.6 and 2.7
         hereof, up to 50,000 Shares for an amount per Share equal to the
         Exercise Price, upon the terms and subject to the conditions herein
         contained.

2.2      Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have
         the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on
         the fifth anniversary date hereof, being

<PAGE>   2

         September 30, 1996 (provided that if such day is not a day on which the
         Company is open for business then on the first following day on which
         the Company is open for business) to exercise this option for any
         number of the Optioned Shares up to the maximum number of Shares
         specified in Section 2.1 above.

2.3      The option may be exercised by the Participant or by his executors or
         personal representatives in the circumstances described in Section 4.1
         by providing to the Company notice in writing in the form of Schedule A
         hereto setting out the number of Optioned Shares with respect to which
         the option is being exercised. The notice must be accompanied by a
         certified check, official bank cashier's check or money order in an
         amount equal to the Exercise Price multiplied by the number of Shares
         requested and a duly executed copy of this Agreement.

2.4      The Company shall cause its registrar and transfer agent to deliver to
         the Participant as soon as practicable after receipt of such notice and
         payment a certificate or certificates registered in the name of the
         Participant or as the Participant may direct for the number of Shares
         with respect to which the option is duly exercised.

2.5      Nothing contained in this Agreement or action taken pursuant hereto
         shall obligate the Participant to purchase and/or pay for, or the
         Company to issue, any Shares except those Optioned Shares with respect
         to which the Participant shall have duly exercised the option to
         purchase in accordance with this Agreement.

2.6      Subject to Section 2.7 hereof, the option granted hereunder shall vest
         in the following manner:

         (a)      one-quarter of the option on the first anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1992;

         (b)      one-quarter of the option on the second anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1993;

         (c)      one-quarter of the option on the third anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1994; and

         (d)      one-quarter of the option on the fourth anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1995;

         and, except as provided by Section 6.1, the Participant shall only be
         entitled to exercise this option in the amounts set out above and from
         and after the dates so specified.

2.7      Notwithstanding anything contained in Section 2.6 hereof, the option
         shall continue to vest only so long as the Participant continues to
         serve the Company as a director or officer. Should the Participant
         cease to serve in such capacity ("Termination"), no further vesting of
         the option shall occur and the provisions of Section 3.1 shall apply
         with respect to the exercise of the option to the extent that it has
         vested and has not yet been exercised.


                                       2
<PAGE>   3

3.1      EXPIRATION ON TERMINATION

         Subject to Section 4.1 hereof, upon Termination, such part of the
         option as is then vested but unexercised may be exercised by the
         Participant for a period of ninety (90) days after Termination or such
         later date as the Board of Directors may approve after which time this
         option shall expire; provided, however, that in no event may this
         option be exercised after the Expiration Date.

4.1      DEATH OR PERMANENT DISABILITY

         In the event that on or prior to the Expiration Date, the Participant
         dies or becomes totally and permanently disabled while providing
         serving the Company as a director or officer, this option, to the
         extent then vested but unexercised, may be exercised by the Participant
         for a period up to six (6) months after the death or disability of the
         Participant; provided, however, that in no event may this option be
         exercised after the Expiration Date. Disability shall be defined as in
         Section 22(e)(3) of the Internal Revenue Code of 1986, as amended. For
         the purposes of this provision only, reference to the Participant in
         this Agreement shall be construed as including the executors or
         personal representatives of a deceased Participant. In the event that
         this option is not exercised within the period of six (6) months set
         out above, this option shall expire.

5.1      SUBDIVISION, CONSOLIDATION OR REORGANIZATION

         (a)    In the event of any subdivision, redivision or change of the
         Shares of the Company into a greater number of Shares at any time after
         the date of this Agreement and prior to the Expiration Date of this
         option, the Company shall deliver at the time of exercise of this
         option, but for the same aggregate consideration payable therefor, such
         additional number of Shares as the Participant would have been entitled
         to receive as a result of such subdivision, redivision or change if on
         the record date thereof the Participant had been the registered holder
         of the number of such Shares with respect to which the option is later
         exercised.

         (b)    In the event of any consolidation or change of the Shares of the
         Company into a lesser number of Shares at any time after the date of
         this Agreement and prior to the expiration of this option, the Company
         shall deliver at the time of exercise of this option, but for the same
         aggregate consideration payable therefor, such reduced number of
         Shares, as the Participant would have been entitled to receive upon
         such consolidation or change if on the record date thereof the
         Participant had been the registered holder of the number of such Shares
         with respect to which the option is later exercised.

         (c)    If at any time after the date of this Agreement and prior to the
         expiration of this option, the Shares shall be reclassified or
         reorganized, otherwise than as specified in Sections 5.1(a) and (b),
         the Participant shall be entitled to receive upon the exercise of this
         option and shall accept in lieu of the number of Shares then subscribed
         for, but for the same aggregate consideration payable therefor, the
         same aggregate number of shares of the appropriate class of shares that
         the Participant would have been entitled to receive as a result of such
         reclassification or other reorganization of Shares if on the record
         date thereof the Participant


                                       3
<PAGE>   4

         had been the registered holder of the number of such Shares with
         respect to which the option is later exercised.

6.1      TAKE-OVER BID

         If an offeror makes an offer to purchase 50% or more of the outstanding
         Shares to substantially all holders of the Shares or, if an insider of
         the Company makes an offer to purchase Shares to substantially all
         holders of the Shares, and the Board of Directors recommends acceptance
         of such offer to the shareholders of the Company and the offer price is
         greater than the Exercise Price, then this option, whether or not it
         has vested in whole or in part, shall become immediately exercisable.
         The Participant shall be bound to exercise this option and to tender
         the Optioned Shares issued upon exercise of this option into the offer
         upon receipt of notice from the Company if the Company provides an
         interest-free loan to the Participant in the amount of the Exercise
         Price for all of the Optioned Shares issuable upon exercise of this
         option, subject to the execution of a security agreement by the
         Participant in favor of the Company securing repayment of the loan.

7.1      NO ASSIGNMENT

         The Participant may not assign, transfer, pledge or hypothecate any of
         his rights hereunder in any way (whether by operation of law or
         otherwise) except by will or by the laws of succession on intestacy
         which may apply to the estate of the Participant upon his death. The
         option granted herein shall not be subject to execution, attachment or
         similar process. Upon any attempt to assign, transfer, pledge,
         hypothecate or otherwise dispose of this option contrary to the
         provisions hereof, or upon the levy of any attachment or similar
         process upon the option granted herein, such option shall immediately
         become void.

8.1      GENERAL

         (a)    Time shall be of the essence of this Agreement.

         (b)    In this Agreement, words importing the singular number include
         the plural and vice versa and words importing the masculine gender
         include the feminine and neuter genders.

         (c)    All notices which may be or are required to be given by one
         party to the other party pursuant to this Agreement shall be in writing
         and shall be mailed by first class or certified mail, return receipt
         requested, postage prepaid, or transmitted by hand delivery as follows:

         If to the Company:        Deprenyl USA, Inc.
                                   378 Roncesvalles Ave.
                                   Toronto, ON M6R 2M7
                                   CANADA

                                   Attention:  Dr. D. Geoffrey Shulman


                                       4
<PAGE>   5


                  with a copy to:  Nanette W. Mantell, Esq., Corporate Secretary
                                   Lane and Mantell
                                   991 Route 22 West
                                   PO Box 8539
                                   Somerville, NJ 08876
                                   U.S.A.

         If to the Participant:    at the address of the Participant from time
                                   to time in the records of the Company,

         or such other address as to which either party may from time to time
         notify the other as aforesaid.

9.1      RESTRICTIONS ON TRANSFER

         The Participant understands and acknowledges that the option and Shares
         underlying the option have not been registered and that they are
         subject to certain restrictions on transfer under the Securities Act of
         1933 of the United States, as amended, (the "1933 Act"); such
         restrictions provide that the Shares may not be sold without
         registration or exemption from registration under the 1933 Act; and,
         for purposes of the Securities Act (Ontario) (the "Ontario Act"), the
         first trade of the Shares issued pursuant to the exercise of the
         option, other than a trade exempted by the Ontario Act, will be a
         distribution unless the Company has been a reporting issuer for at
         least twelve (12) months and the Company is not in default of any
         requirement of the Ontario Act, disclosure has been made to the Ontario
         Securities Commission of the exempt trade, no unusual effort is made to
         prepare the market or create a demand for the Shares, and no
         extraordinary commission or consideration is paid with respect to the
         trade, provided that such first trade is not from the holdings of a
         so-called "control block".

10.1     REPORTING REQUIREMENTS

         The Participant understands and acknowledges that he will be subject to
         certain reporting requirements upon his receipt and exercise of the
         option, and in connection therewith, upon the receipt and exercise of
         the option, the Participant agrees to timely file with the Securities
         and Exchange Commission, the National Association of Securities
         Dealers, Inc., and any appropriate Canadian securities regulatory
         authorities, the appropriate documentation regarding his ownership of
         the Company's securities.


                                       5
<PAGE>   6

         IN WITNESS WHEREOF, this Agreement has been duly executed by the
parties hereto.

Attest:                                  DEPRENYL USA, INC.
                                         a New Jersey corporation


 s/Edward L. Foster                      By:  s/ D. Geoffrey Shulman
- ------------------------------              ------------------------------------
Edward L. Foster, Treasurer                   Dr. D. Geoffrey Shulman, President


                                         PARTICIPANT


                                         s/D. Geoffrey Shulman
                                         ---------------------------------------
                                         Dr. D. Geoffrey Shulman


                                       6
<PAGE>   7

                                   SCHEDULE A

                                SUBSCRIPTION FORM


To:      The Secretary of Deprenyl USA, Inc.

         Pursuant to the terms and subject to the conditions set forth in the
Stock Option Agreement (the "Agreement") dated      , between Deprenyl USA, Inc.
and the undersigned, I hereby elect to purchase      shares of Common Stock of
Deprenyl USA, Inc. I understand that such purchase is subject to all the terms
and conditions of the Agreement. I request that the certificates for such shares
of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

         In full payment of the purchase price with respect to the Optioned
Shares exercised, the undersigned hereby tenders payment of $___________ by
certified check or official bank cashier's check or money order payable in
Canadian currency to the order of Deprenyl USA, Inc.

Dated:                            X
                                   ---------------------------------------------
                                           (Signature)

                                           -------------------------------------
                                           Name (Please Print)

                                           -------------------------------------
                                           (Address)

                                           -------------------------------------
                                           Taxpayer Identification Number

<PAGE>   8

                                                                  Exhibit 4.4(b)

                             STOCK OPTION AGREEMENT


       THIS AGREEMENT is made as of the 16th day of March, 1993 between DEPRENYL
USA, INC., a corporation incorporated under the laws of the State of New Jersey
(hereinafter referred to as the "Company") and D. GEOFFREY SHULMAN, an
individual residing in the Province of Ontario, CANADA (hereinafter referred to
as the "Participant").

       WITNESSETH:

       WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant him an option to
purchase Shares on the terms and conditions set forth in this Agreement.

       NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:


1.1    DEFINITIONS

       In this Agreement:

       "Board of Directors" means the board of directors of the Company;

       "Exercise Price" means CDN. $10.875;

       "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later of
       the dates provided in Section 2.2;

       "Management Agreement" means an agreement dated October 1, 1991 between
       the Company and Deprenyl Research Limited pursuant to which Deprenyl
       Research Limited will provide to the Company administrative, financial,
       scientific and marketing support, and other management services which may
       be required by the Company;

       "Optioned Shares" means that number of Shares which are subject to the
       option granted by the Company to the Participant pursuant to this
       Agreement;

       "Research Institution" means the research institution with which the
       Participant was affiliated as of the date hereof;

       "Services" means consulting or other services provided by the Participant
       to the Company with respect to 5-aminolevulinic acid photodynamic therapy
       or improvements thereon or in connection with the Management Agreement;
       and

       "Shares" means shares of Common Stock in the share capital of the
       Company.

<PAGE>   9

2.1    GRANT OF OPTION

       The Company hereby grants to the Participant an option to purchase, in
       accordance with the vesting rights outlined in Sections 2.6 and 2.7
       hereof, up to 25,000 Shares for an amount per Share equal to the Exercise
       Price, upon the terms and subject to the conditions herein contained.

2.2    Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have
       the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on the
       fifth anniversary date hereof, being March 16, 1998, provided that if
       such day is not a day on which the Company is open for business then on
       the first following day on which the Company is open for business, to
       exercise this option for any number of the Optioned Shares up to the
       maximum number of Shares specified in Section 2.1 above.

2.3    The option may be exercised by the Participant or by his executors or
       personal representatives in the circumstances described in Section 4.1 by
       giving to the Company at its registered office notice in writing in the
       form of Schedule A hereto setting out the number of Optioned Shares with
       respect to which the option is being exercised. The notice must be
       accompanied by a certified check, official bank cashier's check or money
       order in an amount equal to the Exercise Price multiplied by the number
       of Shares requested and a duly executed copy of this Agreement.

2.4    The Company shall cause its registrar and transfer agent to deliver to
       the Participant as soon as practicable after receipt of such notice and
       payment a certificate or certificates registered in the name of the
       Participant or as the Participant may direct for the number of Shares
       with respect to which the option is duly exercised.

2.5    Nothing contained in this Agreement or done pursuant hereto shall
       obligate the Participant to purchase and/or pay for, or the Company to
       issue, any Shares except those Optioned Shares with respect to which the
       Participant shall have duly exercised the option to purchase in
       accordance with this Agreement.

2.6    Subject to Sections 2.1 and 2.7 hereof, the option granted hereunder
       shall vest in the Participant in the following manner:

       (a)    one-quarter of the option on the first anniversary of the day
              immediately preceding the date hereof, being March 15, 1994;

       (b)    one-quarter of the option on the second anniversary of the day
              immediately preceding the date hereof, being March 15, 1995;

       (c)    one-quarter of the option on the third anniversary of the day
              immediately preceding the date hereof, being March 15, 1996; and

       (d)    one-quarter of the option on the fourth anniversary of the day
              immediately preceding the date hereof, being March 15, 1997;

                                       2
<PAGE>   10

       and, except as provided by Section 6.1, the Participant shall only be
       entitled to exercise this option in the amounts set out above and from
       and after the dates so specified.

2.7    Notwithstanding anything contained in Sections 2.1 and 2.6 hereof,
       options shall continue to vest in the Participant only so long as the
       Participant shall continue to be (a) employed or engaged by the Company
       as an employee, director or officer, (b) providing Services to the
       Company in connection with the Management Agreement, or (c) affiliated
       with the Research Institution and providing Services when requested by
       the Company. Immediately upon the Participant's ceasing to be so
       employed, engaged, or affiliated, or upon termination of the provision of
       Services (collectively, "Termination"), no further options shall vest or
       become exercisable, except at the discretion of the board, and the
       provisions of Section 3.1 shall apply with respect to the exercise of
       those options which have already vested in the Participant and have not
       yet been exercised. The Board of Directors shall be entitled to determine
       if and when Termination has occurred with respect to a Participant.

3.1    EXPIRATION ON TERMINATION

       Subject to Section 4.1 hereof, upon Termination, such part of the option
       as is then exercisable or vested but unexercised may be exercised by the
       Participant for a period of ninety (90) days after Termination or such
       later date as the Board of Directors may approve after which time this
       option shall expire; provided, however, that in no event may this option
       be exercised after the Expiration Date.

4.1    DEATH OR PERMANENT DISABILITY OF EMPLOYEE

       In the event that on or prior to the Expiration Date, the Participant
       dies or becomes totally and permanently disabled while (a) employed or
       engaged by the Company as an employee, director or officer, (b) employed
       by Deprenyl Research Limited and providing Services to the Company in
       connection with the Management Agreement or (c) affiliated with the
       Research Institution and providing Services when requested by the
       Company, this option, to the extent then exercisable but unexercised, may
       be exercised by the Participant for a period of six (6) months after the
       death or disability of the Participant, notwithstanding the Expiration
       Date. The Board of Directors shall be entitled to determine if and when a
       Participant has become permanently disabled. For the purposes of this
       provision only, reference to the Participant in this Agreement shall be
       construed as including the executors or personal representatives of a
       deceased Participant. In the event that this option is not exercised
       within the period of six (6) months set out above, this option shall
       expire.

5.1    SUBDIVISION, CONSOLIDATION OR REORGANIZATION

       (a) In the event of any subdivision, redivision or change of the Shares
       of the Company into a greater number of Shares at any time after the date
       of this Agreement and prior to the Expiration Date of this option, the
       Company shall deliver at the time of exercise of this option, but for the
       same aggregate consideration payable therefor, such additional number of
       Shares as the Participant would have been entitled to receive as a result
       of such subdivision, redivision or change if on the record date thereof
       the Participant had been the

                                       3
<PAGE>   11

       registered holder of the number of such Shares with respect to which the
       option is later exercised.

       (b)    In the event of any consolidation or change of the Shares of the
       Company into a lesser number of Shares at any time after the date of this
       Agreement and prior to the expiration of this option, the Company shall
       deliver at the time of exercise of this option, but for the same
       aggregate consideration payable therefor, such reduced number of Shares,
       as the Participant would have been entitled to receive upon such
       consolidation or change if on the record date thereof the Participant had
       been the registered holder of the number of such Shares with respect to
       which the option is later exercised.

       (c)    If at any time after the date of this Agreement and prior to the
       expiration of this option, the Shares shall be reclassified or
       reorganized, otherwise than as specified in Sections 5.1(a) and (b), the
       Participant shall be entitled to receive upon the exercise of this option
       and shall accept in lieu of the number of Shares then subscribed for, but
       for the same aggregate consideration payable therefor, the same aggregate
       number of shares of the appropriate class of shares that the Participant
       would have been entitled to receive as a result of such reclassification
       or other reorganization of Shares if on the record date thereof the
       Participant had been the registered holder of the number of such Shares
       with respect to which the option is later exercised.

6.1    TAKE-OVER BID

       If an offeror makes an offer to purchase 50% or more of the outstanding
       Shares to substantially all holders of the Shares or, if an insider of
       the Company makes an offer to purchase Shares to substantially all
       holders of the Shares, and the Board of Directors recommends acceptance
       of such offer to the shareholders of the Company and the offer price is
       greater than the Exercise Price, then this option, whether or not it has
       vested in whole or in part in the Participant, shall become immediately
       exercisable. The Participant shall be bound to exercise this option and
       to tender the Optioned Shares issued upon exercise of this option into
       the offer upon receipt of notice from the Company if the Company provides
       an interest-free loan to the Participant in the amount of the Exercise
       Price for all of the Optioned Shares issuable upon exercise of this
       option, subject to the execution of a security agreement by the
       Participant in favor of the Company securing repayment of the loan.

7.1    NO ASSIGNMENT

       The Participant may not assign, transfer, pledge or hypothecate any of
       his rights hereunder in any way (whether by operation of law or
       otherwise) except by will or by the laws of succession on intestacy which
       may apply to the estate of the Participant upon his death. The option
       granted herein shall not be subject to execution, attachment or similar
       process. Upon any attempt to assign, transfer, pledge, hypothecate or
       otherwise dispose of this option contrary to the provisions hereof, or
       upon the levy of any attachment or similar process upon the option
       granted herein, such option shall immediately become void.

                                       4
<PAGE>   12

8.1    GENERAL

       (a)    Time shall be of the essence of this Agreement.

       (b)    In this Agreement, words importing the singular number include the
       plural and vice versa and words importing the masculine gender include
       the feminine and neuter genders.

       (c)    All notices which may be or are required to be given by one party
       to the other party pursuant to this Agreement shall be in writing and
       shall be mailed by first class or certified mail, return receipt
       requested, postage prepaid, or transmitted by hand delivery as follows:

<TABLE>
<S>                                      <C>
       If to the Company:                 Deprenyl USA, Inc.
                                          378 Roncesvalles Ave.
                                          Toronto, ON M6R 2M7
                                          CANADA

                                          Attention:  Mr. Edward L. Foster

       If to the Participant:             Dr. D. Geoffrey Shulman

                                          at the address of the Participant from time to time in
                                          the records of the Company,
</TABLE>

       or such other address as to which either party may from time to time
       notify the other as aforesaid.

9.1    RESTRICTIONS ON TRANSFER

       The Participant understands and acknowledges that he is subject to
       certain restrictions on transfer under the Securities Act of 1933 of the
       United States, as amended, (the "1933 Act") of the Shares issued pursuant
       to the exercise of the option; such restrictions provide that the Shares
       may not be sold without registration or exemption from registration under
       the 1933 Act; and, for purposes of the Securities Act (Ontario) (the
       "Ontario Act"), the first trade of such Shares, other than a trade
       exempted by the Ontario Act, will be a distribution unless the Company
       has been a reporting issuer for at least twelve (12) months and the
       Company is not in default of any requirement of the Ontario Act,
       disclosure has been made to the Ontario Securities Commission of the
       exempt trade, no unusual effort is made to prepare the market or create a
       demand for the Shares, and no extraordinary commission or consideration
       is paid with respect to the trade, provided that such first trade is not
       from the holdings of a so-called "control block".

10.1   REPORTING REQUIREMENTS

       The Participant understands and acknowledges that he may be subject to
       certain reporting requirements upon his exercise of the option, and in
       connection therewith, upon the receipt and exercise of the option, the
       Participant agrees to timely file with the Securities and Exchange
       Commission, the National Association of Securities Dealers, Inc., and any

                                       5
<PAGE>   13

       appropriate Canadian securities regulatory authorities, the appropriate
       documentation regarding his ownership of the Company's securities.


       IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
       hereto.

<TABLE>
<S>                                         <C>
Attest:                                      DEPRENYL USA, INC.
                                             a New Jersey corporation



s/Nanette W. Mantell                         By: s/Edward L. Foster
- --------------------------------                 ------------------------------
Nanette W. Mantell, Secretary                    Edward L. Foster, Treasurer




                                             PARTICIPANT


                                             s/D. Geoffrey Shulman
                                             ----------------------------------
                                             D. GEOFFREY SHULMAN, Chairman,
                                             President and CEO
</TABLE>

                                       6
<PAGE>   14

                                   SCHEDULE A

                                SUBSCRIPTION FORM


To:    The Secretary of Deprenyl USA, Inc.


       Pursuant to the terms and subject to the conditions set forth in the
Stock Option Agreement (the "Agreement") dated       , between Deprenyl USA,
Inc. and the undersigned, and Stock Options granted to the undersigned by such
Agreement, I hereby elect to purchase        shares of Common Stock of Deprenyl
USA, Inc. which were the subject of such Stock Options. I understand that such
purchase is subject to all the terms and conditions of the Agreement. I request
that the certificates for such shares of Common Stock shall be issued in the
name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)


       In full payment of the purchase price with respect to the Stock Options
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian or
United States currency to the order of Deprenyl USA, Inc.



<TABLE>
<S>                          <C>
Dated:                        X
                               -------------------------------------
                                   (Signature)


                                   -------------------------------------
                                   Name (Please Print)


                                   -------------------------------------
                                   (Address)


                                   -------------------------------------
                                   Taxpayer Identification Number
</TABLE>
<PAGE>   15
                                                                  Exhibit 4.4(c)

                             STOCK OPTION AGREEMENT


       THIS AGREEMENT is made as of the 17th day of February, 1994 between DUSA
PHARMACEUTICALS, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and D. GEOFFREY SHULMAN,
MD, FRCPC, an individual residing in the Province of Ontario, CANADA
(hereinafter referred to as the "Participant").

                                   WITNESSETH:

       WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant him an option to
purchase Shares on the terms and conditions set forth in this Agreement.

       NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:


1.1    DEFINITIONS

       In this Agreement:

       "Board of Directors" means the board of directors of the Company;

       "Exercise Price" means CDN.$6.50;

       "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later of
       the dates provided in Section 2.2;

       "Optioned Shares" means that number of Shares which are subject to the
       option granted by the Company to the Participant pursuant to this
       Agreement; and

       "Shares" means shares of Common Stock in the share capital of the
       Company.

2.1    GRANT OF OPTION

       The Company hereby grants to the Participant an option to purchase, in
       accordance with the vesting rights outlined in Sections 2.6 and 2.7
       hereof, up to 10,000 Shares for an amount per Share equal to the Exercise
       Price, upon the terms and subject to the conditions herein contained.

2.2    Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have
       the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on the
       fifth anniversary date hereof, being February 17, 1999, provided that if
       such day is not a day on which the Company is open for business then on
       the first following day on which the Company is open for business, to
<PAGE>   16

       exercise this option for any number of the Optioned Shares up to the
       maximum number of Shares specified in Section 2.1 above.

2.3    The option may be exercised by the Participant or by his executors or
       personal representatives in the circumstances described in Section 4.1 by
       giving to the Company at its registered office notice in writing in the
       form of Schedule A hereto setting out the number of Optioned Shares with
       respect to which the option is being exercised. The notice must be
       accompanied by a certified check, official bank cashier's check or money
       order in an amount equal to the Exercise Price multiplied by the number
       of Shares requested and a duly executed copy of this Agreement.

2.4    The Company shall cause its registrar and transfer agent to deliver to
       the Participant as soon as practicable after receipt of such notice and
       payment a certificate or certificates registered in the name of the
       Participant or as the Participant may direct for the number of Shares
       with respect to which the option is duly exercised.

2.5    Nothing contained in this Agreement or done pursuant hereto shall
       obligate the Participant to purchase and/or pay for, or the Company to
       issue, any Shares except those Optioned Shares with respect to which the
       Participant shall have duly exercised the option to purchase in
       accordance with this Agreement.

2.6    Subject to Sections 2.1 and 2.7 hereof, the option granted hereunder
       shall vest in the Participant in the following manner:

       (a)    one-quarter of the option on the first anniversary of the day
              immediately preceding the date hereof, being February 16, 1995;

       (b)    one-quarter of the option on the second anniversary of the day
              immediately preceding the date hereof, being February 16, 1996;

       (c)    one-quarter of the option on the third anniversary of the day
              immediately preceding the date hereof, being February 16, 1997;
              and

       (d)    one-quarter of the option on the fourth anniversary of the day
              immediately preceding the date hereof, being February 16, 1998;

       and, except as provided by Section 6.1, the Participant shall only be
       entitled to exercise this option in the amounts set out above and from
       and after the dates so specified.

2.7    Notwithstanding anything contained in Sections 2.1 and 2.6 hereof,
       options shall continue to vest in the Participant only so long as the
       Participant shall continue to serve the Company as a director and/or
       officer. Should the Participant cease to serve in such capacity (the
       "Termination"), no further options shall vest or become exercisable,
       except at the discretion of the Board of Directors, and the provisions of
       Section 3.1 shall apply with respect to the exercise of those options
       which have already vested in the Participant and have not yet been
       exercised. The Board of Directors shall be entitled to determine if and
       when Termination has occurred with respect to the Participant.

                                       2
<PAGE>   17

3.1    EXPIRATION ON TERMINATION

       Subject to Section 4.1 hereof, upon Termination, such part of the option
       as is then exercisable but unexercised may be exercised by the
       Participant for a period of ninety (90) days after Termination or such
       later date as the Board of Directors may approve after which time this
       option shall expire; provided, however, that in no event may this option
       be exercised after the Expiration Date.

4.1    DEATH OR PERMANENT DISABILITY OF EMPLOYEE

       In the event that on or prior to the Expiration Date, the Participant
       dies or becomes totally and permanently disabled while serving the
       Company as a director or officer, this option, to the extent then
       exercisable but unexercised, may be exercised by the Participant for a
       period of six (6) months after the death or disability of the
       Participant, [notwithstanding the Expiration Date]. The Board of
       Directors shall be entitled to determine if and when a Participant has
       become permanently disabled. For the purposes of this provision only,
       reference to the Participant in this Agreement shall be construed as
       including the executors or personal representatives of a deceased
       Participant. In the event that this option is not exercised within the
       period of six (6) months set out above, this option shall expire.

5.1    SUBDIVISION, CONSOLIDATION OR REORGANIZATION

       (a)    In the event of any subdivision, redivision or change of the
       Shares of the Company into a greater number of Shares at any time after
       the date of this Agreement and prior to the Expiration Date of this
       option, the Company shall deliver at the time of exercise of this option,
       but for the same aggregate consideration payable therefor, such
       additional number of Shares as the Participant would have been entitled
       to receive as a result of such subdivision, redivision or change if on
       the record date thereof the Participant had been the registered holder of
       the number of such Shares with respect to which the option is later
       exercised.

       (b)    In the event of any consolidation or change of the Shares of the
       Company into a lesser number of Shares at any time after the date of this
       Agreement and prior to the expiration of this option, the Company shall
       deliver at the time of exercise of this option, but for the same
       aggregate consideration payable therefor, such reduced number of Shares,
       as the Participant would have been entitled to receive upon such
       consolidation or change if on the record date thereof the Participant had
       been the registered holder of the number of such Shares with respect to
       which the option is later exercised.

       (c)    If at any time after the date of this Agreement and prior to the
       expiration of this option, the Shares shall be reclassified or
       reorganized, otherwise than as specified in Sections 5.1(a) and (b), the
       Participant shall be entitled to receive upon the exercise of this option
       and shall accept in lieu of the number of Shares then subscribed for, but
       for the same aggregate consideration payable therefor, the same aggregate
       number of shares of the appropriate class of shares that the Participant
       would have been entitled to receive as a result of such

                                       3
<PAGE>   18

       reclassification or other reorganization of Shares if on the record date
       thereof the Participant had been the registered holder of the number of
       such Shares with respect to which the option is later exercised.


6.1    TAKE-OVER BID

       If an offeror makes an offer to purchase 50% or more of the outstanding
       Shares to substantially all holders of the Shares or, if an insider of
       the Company makes an offer to purchase Shares to substantially all
       holders of the Shares, and the Board of Directors recommends acceptance
       of such offer to the shareholders of the Company and the offer price is
       greater than the Exercise Price, then this option, whether or not it has
       vested in whole or in part in the Participant, shall become immediately
       exercisable. The Participant shall be bound to exercise this option and
       to tender the Optioned Shares issued upon exercise of this option into
       the offer upon receipt of notice from the Company if the Company provides
       an interest-free loan to the Participant in the amount of the Exercise
       Price for all of the Optioned Shares issuable upon exercise of this
       option, subject to the execution of a security agreement by the
       Participant in favor of the Company securing repayment of the loan.

7.1    NO ASSIGNMENT

       The Participant may not assign, transfer, pledge or hypothecate any of
       his rights hereunder in any way (whether by operation of law or
       otherwise) except by will or by the laws of succession on intestacy which
       may apply to the estate of the Participant upon his death. The option
       granted herein shall not be subject to execution, attachment or similar
       process. Upon any attempt to assign, transfer, pledge, hypothecate or
       otherwise dispose of this option contrary to the provisions hereof, or
       upon the levy of any attachment or similar process upon the option
       granted herein, such option shall immediately become void.

8.1    GENERAL

       (a)    Time shall be of the essence of this Agreement.

       (b)    In this Agreement, words importing the singular number include the
       plural and vice versa and words importing the masculine gender include
       the feminine and neuter genders.

       (c)    All notices which may be or are required to be given by one party
       to the other party pursuant to this Agreement shall be in writing and
       shall be mailed by first class or certified mail, return receipt
       requested, postage prepaid, or transmitted by hand delivery as follows:

<TABLE>
<S>                                        <C>
       If to the Company:                    DUSA Pharmaceuticals, Inc.
                                             337 Roncesvalles Avenue
                                             Toronto, ON M6R 2M8
                                             CANADA

                                             Attention:  Edward L. Foster, CA
</TABLE>



                                       4
<PAGE>   19

<TABLE>
<S>                                        <C>
       If to the Participant:                Dr. D. Geoffrey Shulman

                                             at the address of the Participant
                                             from time to time in the records of
                                             the Company,
</TABLE>

       or such other address as to which either party may from time to time
       notify the other as aforesaid.

9.1    RESTRICTIONS ON TRANSFER

       The Participant understands and acknowledges that he is subject to
       certain restrictions on transfer under the Securities Act of 1933 of the
       United States, as amended, (the "1933 Act") of the Shares issued pursuant
       to the exercise of the option; such restrictions provide that the Shares
       may not be sold without registration or exemption from registration under
       the 1933 Act; and, for purposes of the Securities Act (Ontario) (the
       "Ontario Act"), the first trade of such Shares, other than a trade
       exempted by the Ontario Act, will be a distribution unless the Company
       has been a reporting issuer for at least twelve (12) months and the
       Company is not in default of any requirement of the Ontario Act,
       disclosure has been made to the Ontario Securities Commission of the
       exempt trade, no unusual effort is made to prepare the market or create a
       demand for the Shares, and no extraordinary commission or consideration
       is paid with respect to the trade, provided that such first trade is not
       from the holdings of a so-called "control block".

10.1   REPORTING REQUIREMENTS

       The Participant understands and acknowledges that he may be subject to
       certain reporting requirements upon his receipt and exercise of the
       option, and in connection therewith, upon the receipt and exercise of the
       option, the Participant agrees to timely file with the Securities and
       Exchange Commission, the National Association of Securities Dealers,
       Inc., and any appropriate Canadian securities regulatory authorities, the
       appropriate documentation regarding his ownership of the Company's
       securities.

                                       5
<PAGE>   20

       IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
       hereto.

<TABLE>
<S>                                         <C>
Attest:                                      DUSA PHARMACEUTICALS, INC.,
                                             a New Jersey corporation



s/Nanette W. Mantell                         By: s/Edward L. Foster
- -------------------------------                  --------------------------------------
Nanette W. Mantell, Secretary                                         Edward L. Foster,
                                                  Chief Financial Officer and Treasurer




                                             PARTICIPANT


                                             s/ D. Geoffrey Shulman
                                             ------------------------------------------
                                             D. GEOFFREY SHULMAN, MD, FRCPC
</TABLE>



                                       6
<PAGE>   21


                                   SCHEDULE A

                                SUBSCRIPTION FORM


To:    The Secretary of DUSA Pharmaceuticals, Inc.


       Pursuant to the terms and subject to the conditions set forth in the
Stock Option Agreement (the "Agreement") dated         , between DUSA
Pharmaceuticals, Inc. and the undersigned, and Stock Options granted to the
undersigned by such Agreement, I hereby elect to purchase        shares of
Common Stock of DUSA Pharmaceuticals, Inc. which were the subject of such Stock
Options. I understand that such purchase is subject to all the terms and
conditions of the Agreement. I request that the certificates for such shares of
Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)


       In full payment of the purchase price with respect to the Stock Options
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian or
United States currency to the order of DUSA Pharmaceuticals, Inc.



<TABLE>
<S>                          <C>
Dated:                        X
                               ----------------------------------------
                                    (Signature)


                                    -------------------------------------------
                                    Name (Please Print)


                                    -------------------------------------------
                                    (Address)


                                    -------------------------------------------
                                    Taxpayer Identification Number
</TABLE>



<PAGE>   1
                                                                     Exhibit 4.5

                             STOCK OPTION AGREEMENT


       THIS AGREEMENT is made as of the 30th day of September, 1991 between
DEPRENYL USA, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and JAMES P. DOHERTY, BSC,
an individual residing at 1 Bachelor Place, Willowdale, Ontario M2L 1W9, CANADA
(hereinafter referred to as the "Participant").

       WITNESSETH:

       WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant an option to him to
purchase shares of the Company's common stock ("Shares") on the terms and
conditions set forth in this Agreement.

       NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:


1.1    DEFINITIONS

       In this Agreement:

       "Board of Directors" means the board of directors of the Company;

       "Exercise Price" means CDN. $6.79;

       "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later of
       the dates provided in Section 2.2;

       "Optioned Shares" means that number of Shares which are subject to the
       option granted by the Company to the Participant pursuant to this
       Agreement; and

       "Shares" means shares of common stock, without par value, of the Company.

2.1    GRANT OF OPTION

       The Company hereby grants to the Participant an option to purchase, in
       accordance with the vesting rights outlined in Sections 2.6 and 2.7
       hereof, up to 50,000 Shares for an amount per Share equal to the Exercise
       Price, upon the terms and subject to the conditions herein contained.

2.2    Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have
       the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on the
       fifth anniversary date hereof, being
<PAGE>   2

       September 30, 1996 (provided that if such day is not a day on which the
       Company is open for business then on the first following day on which the
       Company is open for business) to exercise this option for any number of
       the Optioned Shares up to the maximum number of Shares specified in
       Section 2.1 above.

2.3    The option may be exercised by the Participant or by his executors or
       personal representatives in the circumstances described in Section 4.1 by
       providing to the Company notice in writing in the form of Schedule A
       hereto setting out the number of Optioned Shares with respect to which
       the option is being exercised. The notice must be accompanied by a
       certified check, official bank cashier's check or money order in an
       amount equal to the Exercise Price multiplied by the number of Shares
       requested and a duly executed copy of this Agreement.

2.4    The Company shall cause its registrar and transfer agent to deliver to
       the Participant as soon as practicable after receipt of such notice and
       payment a certificate or certificates registered in the name of the
       Participant or as the Participant may direct for the number of Shares
       with respect to which the option is duly exercised.

2.5    Nothing contained in this Agreement or action taken pursuant hereto shall
       obligate the Participant to purchase and/or pay for, or the Company to
       issue, any Shares except those Optioned Shares with respect to which the
       Participant shall have duly exercised the option to purchase in
       accordance with this Agreement.

2.6    Subject to Section 2.7 hereof, the option granted hereunder shall vest in
       the following manner:

       (a)    one-quarter of the option on the first anniversary of the day
              immediately preceding the date hereof, being September 29, 1992;

       (b)    one-quarter of the option on the second anniversary of the day
              immediately preceding the date hereof, being September 29, 1993;

       (c)    one-quarter of the option on the third anniversary of the day
              immediately preceding the date hereof, being September 29, 1994;
              and

       (d)    one-quarter of the option on the fourth anniversary of the day
              immediately preceding the date hereof, being September 29, 1995;

       and, except as provided by Section 6.1, the Participant shall only be
       entitled to exercise this option in the amounts set out above and from
       and after the dates so specified.

2.7    Notwithstanding anything contained in Section 2.6 hereof, the option
       shall continue to vest only so long as the Participant continues serve to
       the Company as a director or officer. Should the Participant cease serve
       in such capacity ("Termination"), no further vesting of the option shall
       occur and the provisions of Section 3.1 shall apply with respect to the
       exercise of the option to the extent that it has vested and has not yet
       been exercised.

                                       2
<PAGE>   3

3.1    EXPIRATION ON TERMINATION

       Subject to Section 4.1 hereof, upon Termination, such part of the option
       as is then vested but unexercised may be exercised by the Participant for
       a period of ninety (90) days after Termination or such later date as the
       Board of Directors may approve after which time this option shall expire;
       provided, however, that in no event may this option be exercised after
       the Expiration Date.

4.1    DEATH OR PERMANENT DISABILITY

       In the event that on or prior to the Expiration Date, the Participant
       dies or becomes totally and permanently disabled while serving the
       Company as a director or officer, this option, to the extent then vested
       but unexercised, may be exercised by the Participant for a period up to
       six (6) months after the death or disability of the Participant;
       provided, however, that in no event may this option be exercised after
       the Expiration Date. Disability shall be defined as in Section 22(e)(3)
       of the Internal Revenue Code of 1986, as amended. For the purposes of
       this provision only, reference to the Participant in this Agreement shall
       be construed as including the executors or personal representatives of a
       deceased Participant. In the event that this option is not exercised
       within the period of six (6) months set out above, this option shall
       expire.

5.1    SUBDIVISION, CONSOLIDATION OR REORGANIZATION

       (a)    In the event of any subdivision, redivision or change of the
       Shares of the Company into a greater number of Shares at any time after
       the date of this Agreement and prior to the Expiration Date of this
       option, the Company shall deliver at the time of exercise of this option,
       but for the same aggregate consideration payable therefor, such
       additional number of Shares as the Participant would have been entitled
       to receive as a result of such subdivision, redivision or change if on
       the record date thereof the Participant had been the registered holder of
       the number of such Shares with respect to which the option is later
       exercised.

       (b)    In the event of any consolidation or change of the Shares of the
       Company into a lesser number of Shares at any time after the date of this
       Agreement and prior to the expiration of this option, the Company shall
       deliver at the time of exercise of this option, but for the same
       aggregate consideration payable therefor, such reduced number of Shares,
       as the Participant would have been entitled to receive upon such
       consolidation or change if on the record date thereof the Participant had
       been the registered holder of the number of such Shares with respect to
       which the option is later exercised.

       (c)    If at any time after the date of this Agreement and prior to the
       expiration of this option, the Shares shall be reclassified or
       reorganized, otherwise than as specified in Sections 5.1(a) and (b), the
       Participant shall be entitled to receive upon the exercise of this option
       and shall accept in lieu of the number of Shares then subscribed for, but
       for the same aggregate consideration payable therefor, the same aggregate
       number of shares of the appropriate class of shares that the Participant
       would have been entitled to receive as a result of such reclassification
       or other reorganization of Shares if on the record date thereof the
       Participant

                                       3
<PAGE>   4

       had been the registered holder of the number of such Shares with respect
       to which the option is later exercised.

6.1    TAKE-OVER BID

       If an offeror makes an offer to purchase 50% or more of the outstanding
       Shares to substantially all holders of the Shares or, if an insider of
       the Company makes an offer to purchase Shares to substantially all
       holders of the Shares, and the Board of Directors recommends acceptance
       of such offer to the shareholders of the Company and the offer price is
       greater than the Exercise Price, then this option, whether or not it has
       vested in whole or in part, shall become immediately exercisable. The
       Participant shall be bound to exercise this option and to tender the
       Optioned Shares issued upon exercise of this option into the offer upon
       receipt of notice from the Company if the Company provides an
       interest-free loan to the Participant in the amount of the Exercise Price
       for all of the Optioned Shares issuable upon exercise of this option,
       subject to the execution of a security agreement by the Participant in
       favor of the Company securing repayment of the loan.

7.1    NO ASSIGNMENT

       The Participant may not assign, transfer, pledge or hypothecate any of
       his rights hereunder in any way (whether by operation of law or
       otherwise) except by will or by the laws of succession on intestacy which
       may apply to the estate of the Participant upon his death. The option
       granted herein shall not be subject to execution, attachment or similar
       process. Upon any attempt to assign, transfer, pledge, hypothecate or
       otherwise dispose of this option contrary to the provisions hereof, or
       upon the levy of any attachment or similar process upon the option
       granted herein, such option shall immediately become void.

8.1    GENERAL

       (a)    Time shall be of the essence of this Agreement.

       (b)    In this Agreement, words importing the singular number include the
       plural and vice versa and words importing the masculine gender include
       the feminine and neuter genders.

       (c)    All notices which may be or are required to be given by one party
       to the other party pursuant to this Agreement shall be in writing and
       shall be mailed by first class or certified mail, return receipt
       requested, postage prepaid, or transmitted by hand delivery as follows:

<TABLE>
<S>                                        <C>
       If to the Company:                    Deprenyl USA, Inc.
                                             378 Roncesvalles Ave.
                                             Toronto, ON M6R 2M7
                                             CANADA

                                             Attention:  Dr. D. Geoffrey Shulman
</TABLE>



                                       4
<PAGE>   5



<TABLE>
<S>                                        <C>
              with a copy to:                Nanette W. Mantell, Esq., Corporate Secretary
                                             Lane and Mantell
                                             991 Route 22 West
                                             PO Box 8539
                                             Somerville, NJ
                                             08876 U.S.A.

       If to the Participant:                at the address of the Participant from
                                             time to time in the records of the Company,
</TABLE>

       or such other address as to which either party may from time to time
       notify the other as aforesaid.

9.1    RESTRICTIONS ON TRANSFER

       The Participant understands and acknowledges that the option and Shares
       underlying the option have not been registered and that they are subject
       to certain restrictions on transfer under the Securities Act of 1933 of
       the United States, as amended, (the "1933 Act"); such restrictions
       provide that the Shares may not be sold without registration or exemption
       from registration under the 1933 Act; and, for purposes of the Securities
       Act (Ontario) (the "Ontario Act"), the first trade of the Shares issued
       pursuant to the exercise of the option, other than a trade exempted by
       the Ontario Act, will be a distribution unless the Company has been a
       reporting issuer for at least twelve (12) months and the Company is not
       in default of any requirement of the Ontario Act, disclosure has been
       made to the Ontario Securities Commission of the exempt trade, no unusual
       effort is made to prepare the market or create a demand for the Shares,
       and no extraordinary commission or consideration is paid with respect to
       the trade, provided that such first trade is not from the holdings of a
       so-called "control block".

10.1   REPORTING REQUIREMENTS

       The Participant understands and acknowledges that he will be subject to
       certain reporting requirements upon his receipt and exercise of the
       option, and in connection therewith, upon the receipt and exercise of the
       option, the Participant agrees to timely file with the Securities and
       Exchange Commission, the National Association of Securities Dealers,
       Inc., and any appropriate Canadian securities regulatory authorities, the
       appropriate documentation regarding his ownership of the Company's
       securities.

                                       5
<PAGE>   6


       IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
       hereto.

<TABLE>
<S>                                        <C>
Attest:                                      DEPRENYL USA, INC.
                                             a New Jersey corporation



s/Edward L. Foster                           By: s/D. Geoffrey Shulman
- ------------------------------                   ------------------------------------
Edward L. Foster, Treasurer                      Dr. D. Geoffrey
Shulman, President



                                             PARTICIPANT


                                             s/James P. Doherty
                                             ----------------------------------------
                                             James P. Doherty
</TABLE>



                                       6
<PAGE>   7

                                   SCHEDULE A

                                SUBSCRIPTION FORM


To:    The Secretary of Deprenyl USA, Inc.


       Pursuant to the terms and subject to the conditions set forth in the
Stock Option Agreement (the "Agreement") dated         , between Deprenyl USA,
Inc. and the undersigned, I hereby elect to purchase        shares of Common
Stock of Deprenyl USA, Inc. I understand that such purchase is subject to all
the terms and conditions of the Agreement. I request that the certificates for
such shares of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)


       In full payment of the purchase price with respect to the Optioned Shares
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian
currency to the order of Deprenyl USA, Inc.



<TABLE>
<S>                              <C>
Dated:                            X
                                   -----------------------------
                                        (Signature)


                                        ---------------------------------------
                                        Name (Please Print)


                                        ---------------------------------------
                                        (Address)


                                        ---------------------------------------
                                        Taxpayer Identification Number
</TABLE>



<PAGE>   1
                                                                     Exhibit 4.6

                             STOCK OPTION AGREEMENT


       THIS AGREEMENT is made as of the 30th day of September, 1991 between
DEPRENYL USA, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and THEODORE SALL, PHD, an
individual residing at 94 Woodcrest Drive, Woodcliff Lakes, New Jersey 07675
(hereinafter referred to as the "Participant").

       WITNESSETH:

       WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant an option to him to
purchase shares of the Company's common stock ("Shares") on the terms and
conditions set forth in this Agreement.

       NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:


1.1    DEFINITIONS

       In this Agreement:

       "Board of Directors" means the board of directors of the Company;

       "Exercise Price" means U.S. $6.00;

       "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later of
       the dates provided in Section 2.2;

       "Optioned Shares" means that number of Shares which are subject to the
       option granted by the Company to the Participant pursuant to this
       Agreement;

       "Shares" means shares of common stock, without par value, of the Company.

2.1    GRANT OF OPTION

       The Company hereby grants to the Participant an option to purchase, in
       accordance with the vesting rights outlined in Sections 2.6 and 2.7
       hereof, up to 10,000 Shares for an amount per Share equal to the Exercise
       Price, upon the terms and subject to the conditions herein contained.

2.2    Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have
       the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on the
       fifth anniversary date hereof, being September 30, 1996 (provided that if
       such day is not a day on which the Company is open
<PAGE>   2

       for business then on the first following day on which the Company is open
       for business) to exercise this option for any number of the Optioned
       Shares up to the maximum number of Shares specified in Section 2.1 above.

2.3    The option may be exercised by the Participant or by his executors or
       personal representatives in the circumstances described in Section 4.1 by
       providing to the Company notice in writing in the form of Schedule A
       hereto setting out the number of Optioned Shares with respect to which
       the option is being exercised. The notice must be accompanied by a
       certified check, official bank cashier's check or money order in an
       amount equal to the Exercise Price multiplied by the number of Shares
       requested and a duly executed copy of this Agreement.

2.4    The Company shall cause its registrar and transfer agent to deliver to
       the Participant as soon as practicable after receipt of such notice and
       payment a certificate or certificates registered in the name of the
       Participant or as the Participant may direct for the number of Shares
       with respect to which the option is duly exercised.

2.5    Nothing contained in this Agreement or action taken pursuant hereto shall
       obligate the Participant to purchase and/or pay for, or the Company to
       issue, any Shares except those Optioned Shares with respect to which the
       Participant shall have duly exercised the option to purchase in
       accordance with this Agreement.

2.6    Subject to Section 2.7 hereof, the option granted hereunder shall vest in
       the following manner:

       (a)    one-quarter of the option on the first anniversary of the day
              immediately preceding the date hereof, being September 29, 1992;

       (b)    one-quarter of the option on the second anniversary of the day
              immediately preceding the date hereof, being September 29, 1993;

       (c)    one-quarter of the option on the third anniversary of the day
              immediately preceding the date hereof, being September 29, 1994;
              and

       (d)    one-quarter of the option on the fourth anniversary of the day
              immediately preceding the date hereof, being September 29, 1995;

       and, except as provided by Section 6.1, the Participant shall only be
       entitled to exercise this option in the amounts set out above and from
       and after the dates so specified.

2.7    Notwithstanding anything contained in Section 2.6 hereof, the option
       shall continue to vest only so long as the Participant continues to serve
       the Company as a director or officer. Should the Participant cease to
       serve in such capacity ("Termination"), no further vesting of the option
       shall occur and the provisions of Section 3.1 shall apply with respect to
       the exercise of the option to the extent that it has vested and has not
       yet been exercised.

                                       2
<PAGE>   3


3.1    EXPIRATION ON TERMINATION

       Subject to Section 4.1 hereof, upon Termination, such part of the option
       as is then vested but unexercised may be exercised by the Participant for
       a period of ninety (90) days after Termination or such later date as the
       Board of Directors may approve after which time this option shall expire;
       provided, however, that in no event may this option be exercised after
       the Expiration Date.

4.1    DEATH OR PERMANENT DISABILITY

       In the event that on or prior to the Expiration Date, the Participant
       dies or becomes totally and permanently disabled while servicing the
       Company as a director or office, this option, to the extent then vested
       but unexercised, may be exercised by the Participant for a period up to
       six (6) months after the death or disability of the Participant;
       provided, however, that in no event may this option be exercised after
       the Expiration Date. Disability shall be defined as in Section 22(e)(3)
       of the Internal Revenue Code of 1986, as amended. For the purposes of
       this provision only, reference to the Participant in this Agreement shall
       be construed as including the executors or personal representatives of a
       deceased Participant. In the event that this option is not exercised
       within the period of six (6) months set out above, this option shall
       expire.

5.1    SUBDIVISION, CONSOLIDATION OR REORGANIZATION

       (a)    In the event of any subdivision, redivision or change of the
       Shares of the Company into a greater number of Shares at any time after
       the date of this Agreement and prior to the Expiration Date of this
       option, the Company shall deliver at the time of exercise of this option,
       but for the same aggregate consideration payable therefor, such
       additional number of Shares as the Participant would have been entitled
       to receive as a result of such subdivision, redivision or change if on
       the record date thereof the Participant had been the registered holder of
       the number of such Shares with respect to which the option is later
       exercised.

       (b)    In the event of any consolidation or change of the Shares of the
       Company into a lesser number of Shares at any time after the date of this
       Agreement and prior to the expiration of this option, the Company shall
       deliver at the time of exercise of this option, but for the same
       aggregate consideration payable therefor, such reduced number of Shares,
       as the Participant would have been entitled to receive upon such
       consolidation or change if on the record date thereof the Participant had
       been the registered holder of the number of such Shares with respect to
       which the option is later exercised.

       (c)    If at any time after the date of this Agreement and prior to the
       expiration of this option, the Shares shall be reclassified or
       reorganized, otherwise than as specified in Sections 5.1(a) and (b), the
       Participant shall be entitled to receive upon the exercise of this option
       and shall accept in lieu of the number of Shares then subscribed for, but
       for the same aggregate consideration payable therefor, the same aggregate
       number of shares of the appropriate class of shares that the Participant
       would have been entitled to receive as a result of such reclassification
       or other reorganization of Shares if on the record date thereof the
       Participant

                                       3
<PAGE>   4

       had been the registered holder of the number of such Shares with respect
       to which the option is later exercised.

6.1    TAKE-OVER BID

       If an offeror makes an offer to purchase 50% or more of the outstanding
       Shares to substantially all holders of the Shares or, if an insider of
       the Company makes an offer to purchase Shares to substantially all
       holders of the Shares, and the Board of Directors recommends acceptance
       of such offer to the shareholders of the Company and the offer price is
       greater than the Exercise Price, then this option, whether or not it has
       vested in whole or in part, shall become immediately exercisable. The
       Participant shall be bound to exercise this option and to tender the
       Optioned Shares issued upon exercise of this option into the offer upon
       receipt of notice from the Company if the Company provides an
       interest-free loan to the Participant in the amount of the Exercise Price
       for all of the Optioned Shares issuable upon exercise of this option,
       subject to the execution of a security agreement by the Participant in
       favor of the Company securing repayment of the loan.

7.1    NO ASSIGNMENT

       The Participant may not assign, transfer, pledge or hypothecate any of
       his rights hereunder in any way (whether by operation of law or
       otherwise) except by will or by the laws of succession on intestacy which
       may apply to the estate of the Participant upon his death. The option
       granted herein shall not be subject to execution, attachment or similar
       process. Upon any attempt to assign, transfer, pledge, hypothecate or
       otherwise dispose of this option contrary to the provisions hereof, or
       upon the levy of any attachment or similar process upon the option
       granted herein, such option shall immediately become void.

8.1    GENERAL

       (a)    Time shall be of the essence of this Agreement.

       (b)    In this Agreement, words importing the singular number include the
       plural and vice versa and words importing the masculine gender include
       the feminine and neuter genders.

       (c)    All notices which may be or are required to be given by one party
       to the other party pursuant to this Agreement shall be in writing and
       shall be mailed by first class or certified mail, return receipt
       requested, postage prepaid, or transmitted by hand delivery as follows:


<TABLE>
<S>                                         <C>
       If to the Company:                    Deprenyl USA, Inc.
                                             378 Roncesvalles Ave.
                                             Toronto, ON M6R 2M7
                                             CANADA

                                             Attention:  Dr. D. Geoffrey Shulman
</TABLE>



                                       4
<PAGE>   5

<TABLE>
<S>                                         <C>
                 with a copy to:             Nanette W. Mantell, Esq., Corporate Secretary
                                             Lane and Mantell
                                             991 Route 22 West
                                             PO Box 8539
                                             Somerville, NJ 08876
                                             U.S.A.

       If to the Participant:                at the address of the Participant from time
                                             to time in the records of the Company,
</TABLE>

       or such other address as to which either party may from time to time
       notify the other as aforesaid.

9.1    RESTRICTIONS ON TRANSFER

       The Participant understands and acknowledges that the option and Shares
       underlying the option have not been registered and that they are subject
       to certain restrictions on transfer under the Securities Act of 1933 of
       the United States, as amended, (the "1933 Act"); such restrictions
       provide that the Shares may not be sold without registration or exemption
       from registration under the 1933 Act; and, for purposes of the Securities
       Act (Ontario) (the "Ontario Act"), the first trade of the Shares issued
       pursuant to the exercise of the option, other than a trade exempted by
       the Ontario Act, will be a distribution unless the Company has been a
       reporting issuer for at least twelve (12) months and the Company is not
       in default of any requirement of the Ontario Act, disclosure has been
       made to the Ontario Securities Commission of the exempt trade, no unusual
       effort is made to prepare the market or create a demand for the Shares,
       and no extraordinary commission or consideration is paid with respect to
       the trade, provided that such first trade is not from the holdings of a
       so-called "control block".

10.1   REPORTING REQUIREMENTS

       The Participant understands and acknowledges that he will be subject to
       certain reporting requirements upon his receipt and exercise of the
       option, and in connection therewith, upon the receipt and exercise of the
       option, the Participant agrees to timely file with the Securities and
       Exchange Commission, the National Association of Securities Dealers,
       Inc., and any appropriate Canadian securities regulatory authorities, the
       appropriate documentation regarding his ownership of the Company's
       securities.

                                       5
<PAGE>   6

       IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
       hereto.

<TABLE>
<S>                                              <C>
Attest:                                           DEPRENYL USA, INC.
                                                  a New Jersey corporation



s/Edward L. Foster                                By: s/D. Geoffrey Shulman
- ----------------------------------                    ----------------------------------
Edward L. Foster, Treasurer                           Dr. D. Geoffrey Shulman, President



                                                  PARTICIPANT


                                                  s/Theodore Sall
                                                  --------------------------------------
                                                  Theodore Sall, PhD
</TABLE>



                                       6
<PAGE>   7

                                   SCHEDULE A

                                SUBSCRIPTION FORM


To:    The Secretary of Deprenyl USA, Inc.


       Pursuant to the terms and subject to the conditions set forth in the
Stock Option Agreement (the "Agreement") dated         , between Deprenyl USA,
Inc. and the undersigned, I hereby elect to purchase        shares of Common
Stock of Deprenyl USA, Inc. I understand that such purchase is subject to all
the terms and conditions of the Agreement. I request that the certificates for
such shares of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)


       In full payment of the purchase price with respect to the Optioned Shares
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian
currency to the order of Deprenyl USA, Inc.



<TABLE>
<S>                                <C>
Dated:                              X
                                     ----------------------------------
                                           (Signature)


                                           -------------------------------------
                                           Name (Please Print)


                                           -------------------------------------
                                           (Address)


                                           -------------------------------------
                                           Taxpayer Identification Number
</TABLE>








<PAGE>   1
                                                                     Exhibit 4.7

                             STOCK OPTION AGREEMENT


       THIS AGREEMENT is made as of the 17th day of December, 1991 between
DEPRENYL USA, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and RICHARD C. LUFKIN, an
individual residing at 2 Walnut Circle, Basking Ridge, New Jersey 07920
(hereinafter
referred to as the "Participant").

       WITNESSETH:

       WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant an option to him to
purchase shares of the Company's common stock ("Shares") on the terms and
conditions set forth in this Agreement.

       NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:


1.1    DEFINITIONS

       In this Agreement:

       "Board of Directors" means the board of directors of the Company;

       "Exercise Price" means U.S. $6.00

       "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later of
       the dates provided in Section 2.2;

       "Optioned Shares" means that number of Shares which are subject to the
       option granted by the Company to the Participant pursuant to this
       Agreement; and

       "Shares" means shares of common stock, without par value, of the Company.

2.1    GRANT OF OPTION

       The Company hereby grants to the Participant an option to purchase, in
       accordance with the vesting rights outlined in Sections 2.6 and 2.7
       hereof, up to 12,500 Shares for an amount per Share equal to the Exercise
       Price, upon the terms and subject to the conditions herein contained.

2.2    Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have
       the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on the
       fifth anniversary date hereof, being December 17, 1996 (provided that if
       such day is not a day on which the Company is open
<PAGE>   2

       for business then on the first following day on which the Company is open
       for business) to exercise this option for any number of the Optioned
       Shares up to the maximum number of Shares specified in Section 2.1 above.

2.3    The option may be exercised by the Participant or by his executors or
       personal representatives in the circumstances described in Section 4.1 by
       providing to the Company notice in writing in the form of Schedule A
       hereto setting out the number of Optioned Shares with respect to which
       the option is being exercised. The notice must be accompanied by a
       certified check, official bank cashier's check or money order in an
       amount equal to the Exercise Price multiplied by the number of Shares
       requested and a duly executed copy of this Agreement.


2.4    The Company shall cause its registrar and transfer agent to deliver to
       the Participant as soon as practicable after receipt of such notice and
       payment a certificate or certificates registered in the name of the
       Participant or as the Participant may direct for the number of Shares
       with respect to which the option is duly exercised.

2.5    Nothing contained in this Agreement or action taken pursuant hereto shall
       obligate the Participant to purchase and/or pay for, or the Company to
       issue, any Shares except those Optioned Shares with respect to which the
       Participant shall have duly exercised the option to purchase in
       accordance with this Agreement.

2.6    Subject to Section 2.7 hereof, the option granted hereunder shall vest in
       the following manner:

       (a)    one-quarter of the option on the first anniversary of the day
              immediately preceding the date hereof, being December 16, 1992;

       (b)    one-quarter of the option on the second anniversary of the day
              immediately preceding the date hereof, being December 16, 1993;

       (c)    one-quarter of the option on the third anniversary of the day
              immediately preceding the date hereof, being December 16, 1994;
              and

       (d)    one-quarter of the option on the fourth anniversary of the day
              immediately preceding the date hereof, being December 16, 1995;

       and, except as provided by Section 6.1, the Participant shall only be
       entitled to exercise this option in the amounts set out above and from
       and after the dates so specified.

2.7    Notwithstanding anything contained in Section 2.6 hereof, the option
       shall continue to vest only so long as the Participant continues to serve
       the Company as a director or officer. Should the Participant cease to
       serve in such capacity ("Termination"), no further vesting of the option
       shall occur and the provisions of Section 3.1 shall apply with respect to
       the exercise of the option to the extent that it has vested and has not
       yet been exercised.

                                       2
<PAGE>   3


3.1    EXPIRATION ON TERMINATION

       Subject to Section 4.1 hereof, upon Termination, such part of the option
       as is then vested but unexercised may be exercised by the Participant for
       a period of ninety (90) days after Termination or such later date as the
       Board of Directors may approve after which time this option shall expire;
       provided, however, that in no event may this option be exercised after
       the Expiration Date.

4.1    DEATH OR PERMANENT DISABILITY

       In the event that on or prior to the Expiration Date, the Participant
       dies or becomes totally and permanently disabled while serving the
       Company as a director or officer, this option, to the extent then vested
       but unexercised, may be exercised by the Participant for a period up to
       six (6) months after the death or disability of the Participant;
       provided, however, that in no event may this option be exercised after
       the Expiration Date. Disability shall be defined as in Section 22(e)(3)
       of the Internal Revenue Code of 1986, as amended. For the purposes of
       this provision only, reference to the Participant in this Agreement shall
       be construed as including the executors or personal representatives of a
       deceased Participant. In the event that this option is not exercised
       within the period of six (6) months set out above, this option shall
       expire.

5.1    SUBDIVISION, CONSOLIDATION OR REORGANIZATION

       (a)    In the event of any subdivision, redivision or change of the
       Shares of the Company into a greater number of Shares at any time after
       the date of this Agreement and prior to the Expiration Date of this
       option, the Company shall deliver at the time of exercise of this option,
       but for the same aggregate consideration payable therefor, such
       additional number of Shares as the Participant would have been entitled
       to receive as a result of such subdivision, redivision or change if on
       the record date thereof the Participant had been the registered holder of
       the number of such Shares with respect to which the option is later
       exercised.

       (b)    In the event of any consolidation or change of the Shares of the
       Company into a lesser number of Shares at any time after the date of this
       Agreement and prior to the expiration of this option, the Company shall
       deliver at the time of exercise of this option, but for the same
       aggregate consideration payable therefor, such reduced number of Shares,
       as the Participant would have been entitled to receive upon such
       consolidation or change if on the record date thereof the Participant had
       been the registered holder of the number of such Shares with respect to
       which the option is later exercised.

       (c)    If at any time after the date of this Agreement and prior to the
       expiration of this option, the Shares shall be reclassified or
       reorganized, otherwise than as specified in Sections 5.1(a) and (b), the
       Participant shall be entitled to receive upon the exercise of this option
       and shall accept in lieu of the number of Shares then subscribed for, but
       for the same aggregate consideration payable therefor, the same aggregate
       number of shares of the appropriate class of shares that the Participant
       would have been entitled to receive as a result of such reclassification
       or other reorganization of Shares if on the record date thereof the
       Participant

                                       3
<PAGE>   4

       had been the registered holder of the number of such Shares with respect
       to which the option is later exercised.

6.1    TAKE-OVER BID

       If an offeror makes an offer to purchase 50% or more of the outstanding
       Shares to substantially all holders of the Shares or, if an insider of
       the Company makes an offer to purchase Shares to substantially all
       holders of the Shares, and the Board of Directors recommends acceptance
       of such offer to the shareholders of the Company and the offer price is
       greater than the Exercise Price, then this option, whether or not it has
       vested in whole or in part, shall become immediately exercisable. The
       Participant shall be bound to exercise this option and to tender the
       Optioned Shares issued upon exercise of this option into the offer upon
       receipt of notice from the Company if the Company provides an
       interest-free loan to the Participant in the amount of the Exercise Price
       for all of the Optioned Shares issuable upon exercise of this option,
       subject to the execution of a security agreement by the Participant in
       favor of the Company securing repayment of the loan.

7.1    NO ASSIGNMENT

       The Participant may not assign, transfer, pledge or hypothecate any of
       his rights hereunder in any way (whether by operation of law or
       otherwise) except by will or by the laws of succession on intestacy which
       may apply to the estate of the Participant upon his death. The option
       granted herein shall not be subject to execution, attachment or similar
       process. Upon any attempt to assign, transfer, pledge, hypothecate or
       otherwise dispose of this option contrary to the provisions hereof, or
       upon the levy of any attachment or similar process upon the option
       granted herein, such option shall immediately become void.

8.1    GENERAL

       (a)    Time shall be of the essence of this Agreement.

       (b)    In this Agreement, words importing the singular number include the
       plural and vice versa and words importing the masculine gender include
       the feminine and neuter genders.

       (c)    All notices which may be or are required to be given by one party
       to the other party pursuant to this Agreement shall be in writing and
       shall be mailed by first class or certified mail, return receipt
       requested, postage prepaid, or transmitted by hand delivery as follows:

<TABLE>
<S>                                         <C>
       If to the Company:                    Deprenyl USA, Inc.
                                             378 Roncesvalles Ave.
                                             Toronto, ON M6R 2M7
                                             CANADA

                                             Attention:  Dr. D. Geoffrey Shulman
</TABLE>

                                       4
<PAGE>   5



<TABLE>
<S>                                        <C>
              with a copy to:               Nanette W. Mantell, Esq., Corporate Secretary
                                            Lane and Mantell
                                            991 Route 22 West
                                            PO Box 8539
                                            Somerville, NJ 08876
                                            U.S.A.

       If to the Participant:               at the address of the Participant from time
                                            to time in the records of the Company,
</TABLE>

       or such other address as to which either party may from time to time
       notify the other as aforesaid.

9.1    RESTRICTIONS ON TRANSFER

       The Participant understands and acknowledges that the option and Shares
       underlying the option have not been registered and that they are subject
       to certain restrictions on transfer under the Securities Act of 1933 of
       the United States, as amended, (the "1933 Act"); such restrictions
       provide that the Shares may not be sold without registration or exemption
       from registration under the 1933 Act; and, for purposes of the Securities
       Act (Ontario) (the "Ontario Act"), the first trade of the Shares issued
       pursuant to the exercise of the option, other than a trade exempted by
       the Ontario Act, will be a distribution unless the Company has been a
       reporting issuer for at least twelve (12) months and the Company is not
       in default of any requirement of the Ontario Act, disclosure has been
       made to the Ontario Securities Commission of the exempt trade, no unusual
       effort is made to prepare the market or create a demand for the Shares,
       and no extraordinary commission or consideration is paid with respect to
       the trade, provided that such first trade is not from the holdings of a
       so-called "control block".

10.1   REPORTING REQUIREMENTS

       The Participant understands and acknowledges that he will be subject to
       certain reporting requirements upon his receipt and exercise of the
       option, and in connection therewith, upon the receipt and exercise of the
       option, the Participant agrees to timely file with the Securities and
       Exchange Commission, the National Association of Securities Dealers,
       Inc., and any appropriate Canadian securities regulatory authorities, the
       appropriate documentation regarding his ownership of the Company's
       securities.

                                       5
<PAGE>   6

       IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
       hereto.

<TABLE>
<S>                                          <C>
Attest:                                       DEPRENYL USA, INC.
                                              a New Jersey corporation



s/Edward L. Foster                            By: s/D. Geoffrey Shulman
- ------------------------------                    ------------------------------
Edward L. Foster, Treasurer                       Dr. D. Geoffrey Shulman, President



                                              PARTICIPANT


                                              s/Richard C. Lufkin
                                              ----------------------------------
                                              Richard C. Lufkin
</TABLE>

                                       6
<PAGE>   7

                                   SCHEDULE A

                                SUBSCRIPTION FORM


To:    The Secretary of Deprenyl USA, Inc.


       Pursuant to the terms and subject to the conditions set forth in the
Stock Option Agreement (the "Agreement") dated         , between Deprenyl USA,
Inc. and the undersigned, I hereby elect to purchase        shares of Common
Stock of Deprenyl USA, Inc. I understand that such purchase is subject to all
the terms and conditions of the Agreement. I request that the certificates for
such shares of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)


       In full payment of the purchase price with respect to the Optioned Shares
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian
currency to the order of Deprenyl USA, Inc.


<TABLE>
<S>                                       <C>
Dated:                                     X
                                            ------------------------------------
                                                  (Signature)


                                                  -------------------------------------
                                                  Name (Please Print)


                                                  -------------------------------------
                                                  (Address)


                                                  -------------------------------------
                                                  Taxpayer Identification Number
</TABLE>









<PAGE>   1
                                                                     Exhibit 4.8

                             STOCK OPTION AGREEMENT


       THIS AGREEMENT is made as of the 30th day of September, 1991 between
DEPRENYL USA, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and HERBERT F. HABERMAN,
MD, FRCPC, an individual residing at 12 Ridgewood Road, Toronto, ON M5P 1T5
CANADA (hereinafter referred to as the "Participant").

       WITNESSETH:

       WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant an option to him to
purchase shares of the Company's common stock ("Shares") on the terms and
conditions set forth in this Agreement.

       NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:

1.1    DEFINITIONS

       In this Agreement:

       "Board of Directors" means the board of directors of the Company;

       "Exercise Price" means CDN. $6.79;

       "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later of
       the dates provided in Section 2.2;

       "Optioned Shares" means that number of Shares which are subject to the
       option granted by the Company to the Participant pursuant to this
       Agreement;

       "Services" means consulting or other services provided by the Participant
       to the Company pursuant to the Consulting Agreement between the
       Participant and the Company; and

       "Shares" means shares of common stock, without par value, of the Company.
<PAGE>   2

2.1    GRANT OF OPTION

       The Company hereby grants to the Participant an option to purchase, in
       accordance with the vesting rights outlined in Sections 2.6 and 2.7
       hereof, up to 10,000 Shares for an amount per Share equal to the Exercise
       Price, upon the terms and subject to the conditions herein contained.

2.2    Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have
       the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on the
       fifth anniversary date hereof, being September 30, 1996 (provided that if
       such day is not a day on which the Company is open for business then on
       the first following day on which the Company is open for business) to
       exercise this option for any number of the Optioned Shares up to the
       maximum number of Shares specified in Section 2.1 above.

2.3    The option may be exercised by the Participant or by his executors or
       personal representatives in the circumstances described in Section 4.1 by
       providing to the Company notice in writing in the form of Schedule A
       hereto setting out the number of Optioned Shares with respect to which
       the option is being exercised. The notice must be accompanied by a
       certified check, official bank cashier's check or money order in an
       amount equal to the Exercise Price multiplied by the number of Shares
       requested and a duly executed copy of this Agreement.

2.4    The Company shall cause its registrar and transfer agent to deliver to
       the Participant as soon as practicable after receipt of such notice and
       payment a certificate or certificates registered in the name of the
       Participant or as the Participant may direct for the number of Shares
       with respect to which the option is duly exercised.

2.5    Nothing contained in this Agreement or action taken pursuant hereto shall
       obligate the Participant to purchase and/or pay for, or the Company to
       issue, any Shares except those Optioned Shares with respect to which the
       Participant shall have duly exercised the option to purchase in
       accordance with this Agreement.

2.6    Subject to Section 2.7 hereof, the option granted hereunder shall vest in
       the following manner:

       (a)    one-quarter of the option on the first anniversary of the day
              immediately preceding the date hereof, being September 29, 1992;

       (b)    one-quarter of the option on the second anniversary of the day
              immediately preceding the date hereof, being September 29, 1993;

       (c)    one-quarter of the option on the third anniversary of the day
              immediately preceding the date hereof, being September 29, 1994;
              and

       (d)    one-quarter of the option on the fourth anniversary of the day
              immediately preceding the date hereof, being September 29, 1995;

                                       2
<PAGE>   3

       and, except as provided by Section 6.1, the Participant shall only be
       entitled to exercise this option in the amounts set out above and from
       and after the dates so specified.

2.7    Notwithstanding anything contained in Section 2.6 hereof, the option
       shall continue to vest only so long as the Participant continues to
       provide Services to the Company. Should the Participant cease to provide
       such Services ("Termination"), no further vesting of the option shall
       occur unless the Board of Directors determines otherwise and the
       provisions of Section 3.1 shall apply with respect to the exercise of the
       option to the extent that it has vested and has not yet been exercised.

3.1    EXPIRATION ON TERMINATION

       Subject to Section 4.1 hereof, upon Termination, such part of the option
       as is then vested but unexercised may be exercised by the Participant for
       a period of ninety (90) days after Termination or such later date as the
       Board of Directors may approve after which time this option shall expire;
       provided, however, that in no event may this option be exercised after
       the Expiration Date.

4.1    DEATH OR PERMANENT DISABILITY

       In the event that on or prior to the Expiration Date, the Participant
       dies or becomes totally and permanently disabled while providing Services
       to the Company, this option, to the extent then vested but unexercised,
       may be exercised by the Participant for a period up to six (6) months
       after the death or disability of the Participant; provided, however, that
       in no event may this option be exercised after the Expiration Date.
       Disability shall be defined as in Section 22(e)(3) of the Internal
       Revenue Code of 1986, as amended. For the purposes of this provision
       only, reference to the Participant in this Agreement shall be construed
       as including the executors or personal representatives of a deceased
       Participant. In the event that this option is not exercised within the
       period of six (6) months set out above, this option shall expire.

5.1    SUBDIVISION, CONSOLIDATION OR REORGANIZATION

       (a)    In the event of any subdivision, redivision or change of the
       Shares of the Company into a greater number of Shares at any time after
       the date of this Agreement and prior to the Expiration Date of this
       option, the Company shall deliver at the time of exercise of this option,
       but for the same aggregate consideration payable therefor, such
       additional number of Shares as the Participant would have been entitled
       to receive as a result of such subdivision, redivision or change if on
       the record date thereof the Participant had been the registered holder of
       the number of such Shares with respect to which the option is later
       exercised.

       (b)    In the event of any consolidation or change of the Shares of the
       Company into a lesser number of Shares at any time after the date of this
       Agreement and prior to the expiration of this option, the Company shall
       deliver at the time of exercise of this option, but for the same
       aggregate consideration payable therefor, such reduced number of Shares,
       as the Participant would have been entitled to receive upon such
       consolidation or change if on

                                       3
<PAGE>   4

       the record date thereof the Participant had been the registered holder of
       the number of such Shares with respect to which the option is later
       exercised.

       (c)    If at any time after the date of this Agreement and prior to the
       expiration of this option, the Shares shall be reclassified or
       reorganized, otherwise than as specified in Sections 5.1(a) and (b), the
       Participant shall be entitled to receive upon the exercise of this option
       and shall accept in lieu of the number of Shares then subscribed for, but
       for the same aggregate consideration payable therefor, the same aggregate
       number of shares of the appropriate class of shares that the Participant
       would have been entitled to receive as a result of such reclassification
       or other reorganization of Shares if on the record date thereof the
       Participant had been the registered holder of the number of such Shares
       with respect to which the option is later exercised.

6.1    TAKE-OVER BID

       If an offeror makes an offer to purchase 50% or more of the outstanding
       Shares to substantially all holders of the Shares or, if an insider of
       the Company makes an offer to purchase Shares to substantially all
       holders of the Shares, and the Board of Directors recommends acceptance
       of such offer to the shareholders of the Company and the offer price is
       greater than the Exercise Price, then this option, whether or not it has
       vested in whole or in part, shall become immediately exercisable. The
       Participant shall be bound to exercise this option and to tender the
       Optioned Shares issued upon exercise of this option into the offer upon
       receipt of notice from the Company if the Company provides an
       interest-free loan to the Participant in the amount of the Exercise Price
       for all of the Optioned Shares issuable upon exercise of this option,
       subject to the execution of a security agreement by the Participant in
       favor of the Company securing repayment of the loan.

7.1    NO ASSIGNMENT

       The Participant may not assign, transfer, pledge or hypothecate any of
       his rights hereunder in any way (whether by operation of law or
       otherwise) except by will or by the laws of succession on intestacy which
       may apply to the estate of the Participant upon his death. The option
       granted herein shall not be subject to execution, attachment or similar
       process. Upon any attempt to assign, transfer, pledge, hypothecate or
       otherwise dispose of this option contrary to the provisions hereof, or
       upon the levy of any attachment or similar process upon the option
       granted herein, such option shall immediately become void.

8.1    GENERAL

       (a)    Time shall be of the essence of this Agreement.

       (b)    In this Agreement, words importing the singular number include the
       plural and vice versa and words importing the masculine gender include
       the feminine and neuter genders.

       (c)    All notices which may be or are required to be given by one party
       to the other party pursuant to this Agreement shall be in writing and
       shall be mailed by first class or certified mail, return receipt
       requested, postage prepaid, or transmitted by hand delivery as follows:

                                       4
<PAGE>   5


<TABLE>
<S>                                        <C>
       If to the Company:                    Deprenyl USA, Inc.
                                             378 Roncesvalles Ave.
                                             Toronto, ON M6R 2M7
                                             CANADA

                                             Attention:  Dr. D. Geoffrey Shulman


              with a copy to:                Nanette W. Mantell, Esq., Corporate Secretary
                                             Lane and Mantell
                                             991 Route 22 West
                                             PO Box 8539
                                             Somerville, NJ
                                             08876
                                             U.S.A.

       If to the Participant:                at the address of the Participant from time to time in
                                             the records of the Company,
</TABLE>

       or such other address as to which either party may from time to time
       notify the other as aforesaid.

9.1    RESTRICTIONS ON TRANSFER

       The Participant understands and acknowledges that the option and Shares
       underlying the option have not been registered and that they are subject
       to certain restrictions on transfer under the Securities Act of 1933 of
       the United States, as amended, (the "1933 Act"); such restrictions
       provide that the Shares may not be sold without registration or exemption
       from registration under the 1933 Act; and, for purposes of the Securities
       Act (Ontario) (the "Ontario Act"), the first trade of the Shares issued
       pursuant to the exercise of the option, other than a trade exempted by
       the Ontario Act, will be a distribution unless the Company has been a
       reporting issuer for at least twelve (12) months and the Company is not
       in default of any requirement of the Ontario Act, disclosure has been
       made to the Ontario Securities Commission of the exempt trade, no unusual
       effort is made to prepare the market or create a demand for the Shares,
       and no extraordinary commission or consideration is paid with respect to
       the trade, provided that such first trade is not from the holdings of a
       so-called "control block".

                                       5
<PAGE>   6

       IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
       hereto.

<TABLE>
<S>                                          <C>
Attest:                                       DEPRENYL USA, INC.
                                              a New Jersey corporation



s/Edward L. Foster                            By: s/D. Geoffrey Shulman
- -------------------------------                   ------------------------------
Edward L. Foster, Treasurer                       Dr. D. Geoffrey
Shulman, President



                                              PARTICIPANT


                                              s/Herbert F. Haberman
                                              ----------------------------------
                                              Herbert F. Haberman, MD, FRCPC
</TABLE>


                                       6
<PAGE>   7

                                   SCHEDULE A

                                SUBSCRIPTION FORM


To:    The Secretary of Deprenyl USA, Inc.


       Pursuant to the terms and subject to the conditions set forth in the
Stock Option Agreement (the "Agreement") dated         , between Deprenyl USA,
Inc. and the undersigned, I hereby elect to purchase        shares of Common
Stock of Deprenyl USA, Inc. I understand that such purchase is subject to all
the terms and conditions of the Agreement. I request that the certificates for
such shares of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)


       In full payment of the purchase price with respect to the Optioned Shares
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian
currency to the order of Deprenyl USA, Inc.


<TABLE>
<S>                                         <C>
Dated:                                       X
                                              ----------------------------------
                                                   (Signature)


                                                   -------------------------------------
                                                   Name (Please Print)


                                                   -------------------------------------
                                                   (Address)


                                                   -------------------------------------
                                                   Taxpayer Identification Number
</TABLE>










<PAGE>   1
                                                                  Exhibit 4.9(a)

                             STOCK OPTION AGREEMENT

         THIS AGREEMENT is made as of the 30th day of September, 1991 between
DEPRENYL USA, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and JAMES C. KENNEDY, MD,
PHD, an individual residing at             (hereinafter referred to as the
"Participant").

         WITNESSETH:

         WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant an option to him to
purchase shares of the Company's common stock ("Shares") on the terms and
conditions set forth in this Agreement.

         NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:

1.1      DEFINITIONS

         In this Agreement:

         "Board of Directors" means the board of directors of the Company;

         "Exercise Price" means CDN. $6.79;

         "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later
         of the dates provided in Section 2.2;

         "Optioned Shares" means that number of Shares which are subject to the
         option granted by the Company to the Participant pursuant to this
         Agreement;

         "Services" means consulting or other services provided by the
         Participant to the Company, as requested from time to time by the Board
         of Directors, at its sole discretion; and

         "Shares" means shares of common stock, without par value, of the
         Company.


<PAGE>   2




2.1      GRANT OF OPTION

         The Company hereby grants to the Participant an option to purchase, in
         accordance with the vesting rights outlined in Sections 2.6 and 2.7
         hereof, up to 20,000 Shares for an amount per Share equal to the
         Exercise Price, upon the terms and subject to the conditions herein
         contained.

2.2      Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have
         the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on
         the fifth anniversary date hereof, being September 30, 1996 (provided
         that if such day is not a day on which the Company is open for business
         then on the first following day on which the Company is open for
         business) to exercise this option for any number of the Optioned Shares
         up to the maximum number of Shares specified in Section 2.1 above.

2.3      The option may be exercised by the Participant or by his executors or
         personal representatives in the circumstances described in Section 4.1
         by providing to the Company notice in writing in the form of Schedule A
         hereto setting out the number of Optioned Shares with respect to which
         the option is being exercised. The notice must be accompanied by a
         certified check, official bank cashier's check or money order in an
         amount equal to the Exercise Price multiplied by the number of Shares
         requested and a duly executed copy of this Agreement.

2.4      The Company shall cause its registrar and transfer agent to deliver to
         the Participant as soon as practicable after receipt of such notice and
         payment a certificate or certificates registered in the name of the
         Participant or as the Participant may direct for the number of Shares
         with respect to which the option is duly exercised.

2.5      Nothing contained in this Agreement or action taken pursuant hereto
         shall obligate the Participant to purchase and/or pay for, or the
         Company to issue, any Shares except those Optioned Shares with respect
         to which the Participant shall have duly exercised the option to
         purchase in accordance with this Agreement.

2.6      Subject to Section 2.7 hereof, the option granted hereunder shall vest
         in the following manner:

         (a)      one-quarter of the option on the first anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1992;

         (b)      one-quarter of the option on the second anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1993;

         (c)      one-quarter of the option on the third anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1994; and

         (d)      one-quarter of the option on the fourth anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1995;


                                       2
<PAGE>   3



         and, except as provided by Section 6.1, the Participant shall only be
         entitled to exercise this option in the amounts set out above and from
         and after the dates so specified.

2.7      Notwithstanding anything contained in Section 2.6 hereof, the option
         shall continue to vest only so long as the Participant continues to
         provide Services to the Company. Should the Participant cease to
         provide such Services ("Termination"), no further vesting of the option
         shall occur unless the Board of Directors determines otherwise and the
         provisions of Section 3.1 shall apply with respect to the exercise of
         the option to the extent that it has vested and has not yet been
         exercised.

3.1      EXPIRATION ON TERMINATION

         Subject to Section 4.1 hereof, upon Termination, such part of the
         option as is then vested but unexercised may be exercised by the
         Participant for a period of ninety (90) days after Termination or such
         later date as the Board of Directors may approve after which time this
         option shall expire; provided, however, that in no event may this
         option be exercised after the Expiration Date.

4.1      DEATH OR PERMANENT DISABILITY

         In the event that on or prior to the Expiration Date, the Participant
         dies or becomes totally and permanently disabled while providing
         Services to the Company, this option, to the extent then vested but
         unexercised, may be exercised by the Participant for a period up to six
         (6) months after the death or disability of the Participant; provided,
         however, that in no event may this option be exercised after the
         Expiration Date. Disability shall be defined as in Section 22(e)(3) of
         the Internal Revenue Code of 1986, as amended. For the purposes of this
         provision only, reference to the Participant in this Agreement shall be
         construed as including the executors or personal representatives of a
         deceased Participant. In the event that this option is not exercised
         within the period of six (6) months set out above, this option shall
         expire.

5.1      SUBDIVISION, CONSOLIDATION OR REORGANIZATION

         (a) In the event of any subdivision, redivision or change of the Shares
         of the Company into a greater number of Shares at any time after the
         date of this Agreement and prior to the Expiration Date of this option,
         the Company shall deliver at the time of exercise of this option, but
         for the same aggregate consideration payable therefor, such additional
         number of Shares as the Participant would have been entitled to receive
         as a result of such subdivision, redivision or change if on the record
         date thereof the Participant had been the registered holder of the
         number of such Shares with respect to which the option is later
         exercised.

         (b) In the event of any consolidation or change of the Shares of the
         Company into a lesser number of Shares at any time after the date of
         this Agreement and prior to the expiration of this option, the Company
         shall deliver at the time of exercise of this option, but for the same
         aggregate consideration payable therefor, such reduced number of
         Shares, as the Participant would have been entitled to receive upon
         such consolidation or change if on


                                       3
<PAGE>   4


         the record date thereof the Participant had been the registered holder
         of the number of such Shares with respect to which the option is later
         exercised.

         (c)      If at any time after the date of this Agreement and prior to
         the expiration of this option, the Shares shall be reclassified or
         reorganized, otherwise than as specified in Sections 5.1(a) and (b),
         the Participant shall be entitled to receive upon the exercise of this
         option and shall accept in lieu of the number of Shares then subscribed
         for, but for the same aggregate consideration payable therefor, the
         same aggregate number of shares of the appropriate class of shares that
         the Participant would have been entitled to receive as a result of such
         reclassification or other reorganization of Shares if on the record
         date thereof the Participant had been the registered holder of the
         number of such Shares with respect to which the option is later
         exercised.

6.1      TAKE-OVER BID

         If an offeror makes an offer to purchase 50% or more of the outstanding
         Shares to substantially all holders of the Shares or, if an insider of
         the Company makes an offer to purchase Shares to substantially all
         holders of the Shares, and the Board of Directors recommends acceptance
         of such offer to the shareholders of the Company and the offer price is
         greater than the Exercise Price, then this option, whether or not it
         has vested in whole or in part, shall become immediately exercisable.
         The Participant shall be bound to exercise this option and to tender
         the Optioned Shares issued upon exercise of this option into the offer
         upon receipt of notice from the Company if the Company provides an
         interest-free loan to the Participant in the amount of the Exercise
         Price for all of the Optioned Shares issuable upon exercise of this
         option, subject to the execution of a security agreement by the
         Participant in favor of the Company securing repayment of the loan.

7.1      NO ASSIGNMENT

         The Participant may not assign, transfer, pledge or hypothecate any of
         his rights hereunder in any way (whether by operation of law or
         otherwise) except by will or by the laws of succession on intestacy
         which may apply to the estate of the Participant upon his death. The
         option granted herein shall not be subject to execution, attachment or
         similar process. Upon any attempt to assign, transfer, pledge,
         hypothecate or otherwise dispose of this option contrary to the
         provisions hereof, or upon the levy of any attachment or similar
         process upon the option granted herein, such option shall immediately
         become void.

8.1      GENERAL

         (a)      Time shall be of the essence of this Agreement.

         (b)      In this Agreement, words importing the singular number include
         the plural and vice versa and words importing the masculine gender
         include the feminine and neuter genders.

         (c)      All notices which may be or are required to be given by one
         party to the other party pursuant to this Agreement shall be in writing
         and shall be mailed by first class or certified mail, return receipt
         requested, postage prepaid, or transmitted by hand delivery as follows:


                                       4
<PAGE>   5




         If to the Company:            Deprenyl USA, Inc.
                                       378 Roncesvalles Ave.
                                       Toronto, ON M6R 2M7
                                       CANADA

                                       Attention:  Dr. D. Geoffrey Shulman

             with a copy to:           Nanette W. Mantell, Esq.,
                                       Corporate Secretary
                                       Lane and Mantell
                                       991 Route 22 West
                                       PO Box 8539
                                       Somerville, NJ 08876
                                       U.S.A.

         If to the Participant:        at the address of the Participant from
                                       time to time in the records of the
                                       Company,

         or such other address as to which either party may from time to time
         notify the other as aforesaid.

9.1      RESTRICTIONS ON TRANSFER

         The Participant understands and acknowledges that the option and Shares
         underlying the option have not been registered and that they are
         subject to certain restrictions on transfer under the Securities Act of
         1933 of the United States, as amended, (the "1933 Act"); such
         restrictions provide that the Shares may not be sold without
         registration or exemption from registration under the 1933 Act; and,
         for purposes of the Securities Act (Ontario) (the "Ontario Act"), the
         first trade of the Shares issued pursuant to the exercise of the
         option, other than a trade exempted by the Ontario Act, will be a
         distribution unless the Company has been a reporting issuer for at
         least twelve (12) months and the Company is not in default of any
         requirement of the Ontario Act, disclosure has been made to the Ontario
         Securities Commission of the exempt trade, no unusual effort is made to
         prepare the market or create a demand for the Shares, and no
         extraordinary commission or consideration is paid with respect to the
         trade, provided that such first trade is not from the holdings of a
         so-called "control block".


                                       5
<PAGE>   6




         IN WITNESS WHEREOF, this Agreement has been duly executed by the
parties hereto.

Attest:                                  DEPRENYL USA, INC.
                                         a New Jersey corporation

s/Edward L. Foster                       By: s/D. Geoffrey Shulman
- ----------------------------                ------------------------------------
Edward L. Foster, Treasurer                   Dr. D. Geoffrey Shulman, President

                                         PARTICIPANT

                                         s/James C. Kennedy
                                         ---------------------------------------
                                         James C. Kennedy, MD, PhD


                                       6
<PAGE>   7





                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:      The Secretary of Deprenyl USA, Inc.

         Pursuant to the terms and subject to the conditions set forth in the
Stock Option Agreement (the "Agreement") dated      , between Deprenyl USA, Inc.
and the undersigned, I hereby elect to purchase      shares of Common Stock of
Deprenyl USA, Inc. I understand that such purchase is subject to all the terms
and conditions of the Agreement. I request that the certificates for such shares
of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

         In full payment of the purchase price with respect to the Optioned
Shares exercised, the undersigned hereby tenders payment of $___________ by
certified check or official bank cashier's check or money order payable in
Canadian currency to the order of Deprenyl USA, Inc.

Dated:                               X
                                       ----------------------------------
                                              (Signature)

                                              ----------------------------------
                                              Name (Please Print)

                                              ----------------------------------
                                              (Address)

                                              ----------------------------------
                                              Taxpayer Identification Number


<PAGE>   8

                                                                  Exhibit 4.9(b)

                       NONQUALIFIED STOCK OPTION AGREEMENT

         AGREEMENT made and entered into as of the 21ST day of OCTOBER, 1997, by
and between DUSA Pharmaceuticals, Inc., a corporation incorporated under the
laws of the State of New Jersey (the "Company"), and James C. Kennedy, who
resides at 299 Glen Cairn Terrace, Kingston Ontario K7M 4A6, the "(Grantee").

         WHEREAS, the Company granted to PARTEQ RESEARCH AND DEVELOPMENT
INNOVATIONS, a corporation incorporated under the laws of Ontario, CANADA
("PARTEQ") on October 21, 1991 (the "Grant Date") stock options for 85,000
shares of the Company's common stock without par value ("Common Stock") in
connection with the agreement to amend a certain License Agreement dated August
27, 1991; and

         WHEREAS, PARTEQ has determined to assign a certain number of said
options to the Grantee in consideration of services rendered by him to the
Company; and

         WHEREAS, the Company has determined that its interests will be advanced
by acknowledging the assignment by PARTEQ of the options;

         NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, the parties agree as follows:

                                    SECTION 1
                                      GRANT

         1.1      The Company hereby acknowledges the assignment to the Grantee
                  of the right and option (the "Option") to purchase, in
                  accordance with the vesting rights outlined in Sections 3.1
                  and 3.6 hereof, up to 13,200 shares of authorized but unissued
                  Common Stock of the Company on the terms and conditions herein
                  set forth in this Nonqualified Stock Option Agreement.

                                    SECTION 2
                                      PRICE

         2.1      The purchase price of the shares of Common Stock subject to
                  this Option shall be the fair market value of the shares of
                  Common Stock on the Grant Date ($10.875 per share)(the
                  "Exercise Price").

                                    SECTION 3
                                WHEN EXERCISABLE

         3.1      The aggregate number of shares of Common Stock of the Company
                  optioned by this Agreement (the "Optioned Shares") shall vest
                  in the Grantee as follows:


<PAGE>   9





                  (a)      25% of the Option on the first anniversary of the day
                           of the grant, being October 21,1998;

                  (b)      25% of the Option on the second anniversary of the
                           day of grant, being October 21, 1999;

                  (c)      25% of the Option on the third anniversary of the day
                           of the grant, being October 21, 2000;

                  (d)      25% of the Option on the fourth anniversary of the
                           day of the grant, being October 21,2001; and

         and, except as provided by Sections 3.6 and 6.3 hereof, the Grantee
         shall only be entitled to exercise this Option, in whole or in part, in
         the amounts set out above and from and after the dates so specified.

         3.2      Subject to Sections 3.1 and 3.6 hereof, the Grantee shall have
                  the right, at any time prior to 5:00 p.m. (Eastern Standard
                  Time) on the date prior to the tenth anniversary date of the
                  grant, being October 20, 2007, provided that if such day is
                  not a day on which the Company is open for business then on
                  the first following day on which the Company is open for
                  business, to exercise this Option for any number of the
                  Optioned Shares up to the maximum number of shares specified
                  in Section 1.1 above.

         3.3      No less than one thousand (1,000) shares may be purchased upon
                  any one exercise of the Option granted hereby unless the
                  number of shares purchased at such time is the total number of
                  shares in respect of which the Option hereby granted is then
                  exercisable.

         3.4      In no event shall any Option granted hereby be exercisable for
                  a fractional share.

         3.5      From time to time, in its discretion, the Company's Stock
                  Option Committee (the "Committee") may offer the Grantee the
                  right to cancel any Option granted hereunder in exchange for
                  such consideration as the Committee shall determine.

         3.6      Notwithstanding anything contained in Sections 1 and 3.1
                  hereof, the Option shall continue to vest in the Grantee only
                  so long as the Grantee shall continue to provide services to
                  the Company. Should the Grantee cease to provide services to
                  the Company, the Option shall not further vest or become
                  exercisable.

                                    SECTION 4
                                 HOW EXERCISABLE

         4.1      Subject to such administrative regulations as the Committee
                  may from time to time adopt, the Grantee or beneficiary shall,
                  in order to exercise this Option give to the Company at its
                  principal office notice in writing in the form of Schedule A
                  hereto setting out the number of Optioned Shares with respect
                  to which the Option is being exercised. The notice must be
                  accompanied by payment of a certified check,


                                       2
<PAGE>   10


                  official bank cashier's check or money order in an amount
                  equal to the Exercise Price multiplied by the number of shares
                  requested and a duly executed copy of this Agreement. At the
                  discretion of the Committee, the Grantee may pay all or a
                  portion of the purchase price by tender of Common Stock or a
                  combination of stock and cash or other means determined by the
                  Committee.

         4.2      Any notice under this Section shall include an undertaking to
                  furnish or execute such documents as the Committee in its
                  discretion shall deem necessary (i) to evidence such exercise,
                  in whole or in part, of the Option evidenced by this
                  Agreement, (ii) to determine whether registration is then
                  required under the Securities Act of 1933, or any other law,
                  as then in effect, and (iii) to comply with or satisfy the
                  requirements of the Securities Act of 1933, or any other law,
                  as then in effect.

         4.3      The Grantee agrees that all shares purchased by him under the
                  Option will be acquired for investment, not distribution, and
                  that any notice of exercise of the Option must be accompanied
                  by a written representation to that effect, signed by the
                  Grantee.

                                    SECTION 5
                              TERMINATION OF OPTION

         5.1      The Option granted hereby shall terminate and be of no force
                  or effect upon the expiration of ten years from the date of
                  the Grant unless terminated prior to such time as provided
                  below.

         5.2      Subject to Section 3.6, hereof if the Amended and Restated
                  License Agreement is terminated by PARTEQ, the Option may be
                  exercised, to the extent exercisable, for a period of three
                  months after the date of such termination or such later date
                  as the Company's Board of Directors may approve; and if such
                  Agreement is terminated by DUSA, the Option shall continue to
                  vest in the Grantee as provided in Section 3.1 above.

         5.3      Any determination made by the Committee with respect to any
                  matter referred to in this Section 5 shall be final and
                  conclusive on all persons affected thereby.

                                    SECTION 6
                              ADJUSTMENTS TO OPTION

         6.1      Subject to any required action by the Committee and
                  shareholders, the number of shares provided for in the Option,
                  and the price per share thereof shall be proportionately
                  adjusted for any increase or decrease in the number of issued
                  shares of the Company resulting from the payment of a share
                  dividend, a share split or any transaction which is a
                  "corporate transaction" (as defined in the Treasury
                  regulations promulgated under Section 424 of the Code.

         6.2      Subject to any required action by the Committee and
                  shareholders, if the Company shall be the surviving entity in
                  any merger or consolidation, or after a consolidation


                                       3
<PAGE>   11


                  of the Company and one or more entities in which the resulting
                  entity is an independent entity, the Option shall pertain to
                  and apply to the securities of the surviving entity in an
                  amount that the board of directors of the surviving entity, at
                  its sole discretion, determines to be equivalent, as nearly as
                  practicable, to the nearest whole number and class of shares
                  that were subject to the Option. These shares of stock or
                  other securities shall, after such merger or consolidation, be
                  deemed to be shares for all purposes hereof. The aforesaid
                  adjustments, when applicable, shall be made by the Committee,
                  and the Committee's determination shall be final, binding and
                  conclusive.

         6.3      In the event of a Change of Control (as defined below), any
                  and all outstanding Options not fully vested shall
                  automatically vest in full and shall be immediately
                  exercisable. The date on which such accelerated vesting and
                  immediate exercisability shall occur shall be the date of the
                  occurrence of the Change of Control.

                  A "Change of Control" shall be deemed to have taken place upon
                  (i) the acquisition by a third person, including a "group" as
                  defined in Section 13(d)(3) of the Securities Exchange Act of
                  1934, as amended, of shares of the Company having 50% or more
                  of the total number of votes that may be cast for the election
                  of Directors of the Company; (ii) shareholder approval of a
                  transaction for the acquisition of the Company, or
                  substantially all of its assets by another entity or for a
                  merger, reorganization, consolidation or other business
                  combination to which the Company is a part; or (iii) the
                  election during any period of 24 months or less of 50% or more
                  of the Directors of the Company where such Directors were not
                  in office immediately prior to such period provided, however,
                  that no "Change of Control" shall be deemed to have taken
                  place if the Directors of the Company in office on the date of
                  adoption of the Plan, or their successors in office nominated
                  by such Directors, affirmatively approve a resolution to such
                  effect.

                  Except as provided with respect to a Grantee in his stock
                  option agreement or other controlling agreement between him
                  and the Company, to the extent that the acceleration,
                  exercisability or parachute payment attributable to the Option
                  following a Change of Control would result in "excess
                  parachute payments"(1) when the former are aggregated with
                  other payments or benefits to the Grantee, such parachute
                  payments or benefits provided to a Grantee under this
                  Agreement shall be reduced to the extent necessary so that no
                  portion thereof shall be subject to the excise tax imposed by
                  Section 4999 of the Code. This reduction will only be made if
                  it will cause the Grantee's net after-tax benefit to exceed
                  the net after-tax benefit that would have existed if such
                  reduction were not made. "Net after-tax benefit" shall be the
                  sum of (i) all payments and benefits which a Grantee receives
                  or is entitled to receive that would constitute a "parachute
                  payment" under Section 280G of the Code, less (ii) the amount
                  of federal income taxes payable with respect to the payments
                  and



- ----------------------
    (1)"Excess parachute payments" are defined in Section 280G of the Code and
are determined by tax counsel of the Company.
                                       4
<PAGE>   12



                  benefits described in (i) above, calculated at the maximum
                  marginal income tax rate(2) for the year in which such
                  payments and benefits shall be paid to the Grantee, less (iii)
                  the amount of excise taxes imposed with respect to the
                  payments and benefits described in (i) above by Section 4999
                  of the Code.

         6.4      In the event of a change in the Company's shares which is
                  limited to a change of all of its authorized shares with par
                  value into the same number of shares with a different par
                  value or without par value, the shares resulting from any such
                  change shall be deemed to be shares within the meaning of this
                  Agreement.

         6.5      Except as herein before expressly provided in Paragraphs 6.1,
                  6.2, 6.3 and 6.4 of this Section 6, the Grantee shall have no
                  rights by reason of any subdivision or consolidation of shares
                  of any class or payment of any share dividend or any other
                  increase or decrease in the number of shares of any class or
                  by reason of any dissolution, liquidation, merger,
                  consolidation or spin-off of assets or stock of another
                  corporation and any issuance by the Company of shares of any
                  class, or securities convertible into shares of any class,
                  shall not affect the Option, and no adjustment by reason
                  thereof shall be made with respect to the number or price of
                  the Company's shares subject to the Option. The grant of the
                  Option shall not affect in any way the right or power of the
                  Company to make adjustments, reclassifications,
                  reorganizations or changes of its capital or business
                  structure or to merge, consolidate, dissolve, liquidate, sell
                  or transfer all or any part of its business or assets.

                                    SECTION 7
                                    TRANSFER

         7.1      This Option shall not be transferable by the Grantee in any
                  way. During the lifetime of the Grantee, the Option shall be
                  exercisable only by him. Any other attempted assignment,
                  transfer, pledge, hypothecation or other disposition of the
                  Option shall be void and have no effect unless in accordance
                  with the terms set forth herein.

                                    SECTION 8
                                WITHHOLDING TAXES

         8.1      The Company shall have the right to retain and withhold from
                  any payment, under the Option granted, any amount that is to
                  be withheld or otherwise deducted and paid with respect to
                  such payment. At its discretion, the Company may require the
                  Grantee, if it receives shares under a nonqualified stock
                  option grant, to reimburse the Company for any taxes that are
                  required to be withheld by the Company, and may withhold any
                  distribution in whole or in part until the Company is so
                  reimbursed. In lieu thereof, the Company shall have the right
                  to withhold from any other cash amounts due (or to become due)
                  to the Grantee an amount equal to such taxes required to be
                  withheld by the Company to reimburse the Company for any such



- ------------------
     (2)This rate is based on the rate for the year set forth in the Code at the
time of the first payment to the participant.


                                       5
<PAGE>   13


                  taxes, or the Company may retain and withhold a number of
                  shares of Common Stock having a market value not less than the
                  amount of such taxes and cancel (in whole or in part) any
                  shares of Common Stock so withheld in order to reimburse the
                  Company for any such taxes.

                                    SECTION 9
                            IMPACT ON OTHER BENEFITS

         9.1      The value of the Option (either on the date of grant of the
                  Option or at the time the shares are vested) shall not be
                  includable as compensation or earnings for purposes of any
                  other benefit plan offered by the Company.

                                   SECTION 10
                                 ADMINISTRATION

         10.1     The Committee shall have full authority and discretion to
                  decide all matters relating to the administration and
                  interpretation of this Agreement. All such Committee
                  determinations shall be final, conclusive and binding upon the
                  Company, the Grantee and any and all interested parties.

                                   SECTION 11
                                  AMENDMENT(S)

         11.1     This Agreement may not in any way be amended without the
                  Grantee's written consent.

                                   SECTION 12
                                FORCE AND EFFECT

         12.1     The various provisions of this Agreement are severable in
                  their entirety. Any determination of invalidity or
                  unenforceability of any one provision shall have no effect on
                  the continuing force and effect of the remaining provisions.

                                   SECTION 13
                         NOTICE OF DISPOSITION OF SHARES

         13.1     The Grantee agrees that if he should dispose of any shares of
                  Common Stock acquired on the exercise of the Option, including
                  a disposition by sale, exchange, gift or transfer of legal
                  title within twelve (12) months of the date such shares are
                  transferred to the Grantee, the Grantee will notify the
                  Company promptly of such disposition.


                                       6
<PAGE>   14




                                   SECTION 14
                                     NOTICES

         14.1     All notices which may be or are required to be given by one
                  party to the other party pursuant to this Agreement shall be
                  in writing and shall be mailed by first class or certified
                  mail, return receipt requested, postage prepaid, or
                  transmitted by hand delivery as follows:

                  If to the Company:        DUSA Pharmaceuticals, Inc.
                                            181 University Avenue
                                            Suite 1208
                                            Toronto, ON M5H 3M7
                                            CANADA

                                            Attention:  Dr. D. Geoffrey Shulman

                  If to the Grantee:        James C. Kennedy

                  or such other address as to which either party may from time
                  to time notify the other as aforesaid.

                                   SECTION 15
                            RESTRICTIONS ON TRANSFER

         15.1     The Grantee understands and acknowledges that he is subject to
                  certain restrictions on transfer under the Securities Act of
                  1933 of the United States, as amended, (the "1933 Act") of the
                  shares issued pursuant to the exercise of the Option; such
                  restrictions provide that the shares may not be sold without
                  registration or exemption from registration under the 1933
                  Act.

                                   SECTION 16
                             REPORTING REQUIREMENTS

         16.1     The Grantee understands and acknowledges that he may be
                  subject to certain reporting requirements upon his receipt and
                  exercise of the Option, and in connection therewith, upon the
                  receipt and exercise of the Option, the Grantee agrees to
                  timely file with the Securities and Exchange Commission, the
                  National Association of Securities Dealers, Inc., and any
                  appropriate Canadian securities regulatory authorities, the
                  appropriate documentation regarding his ownership of the
                  Company's securities.


                                       7
<PAGE>   15




                                   SECTION 17
                                  GOVERNING LAW

         17.1     This Agreement shall be construed and enforced in accordance
                  with and governed by the laws of the State of New Jersey.

         IN WITNESS WHEREOF, this Agreement has been duly executed by the
parties hereto.

Attest:                                  DUSA PHARMACEUTICALS, INC.,
                                         a New Jersey corporation

s/ Nanette W. Mantell                    By: s/D. Geoffrey Shulman
- --------------------------------           --------------------------------
Nanette W. Mantell, Secretary                Dr. D. Geoffrey Shulman, President

                                         GRANTEE

                                             s/James C. Kennedy
                                             ------------------------------
                                             James C. Kennedy


                                       8
<PAGE>   16




                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:      The Secretary of DUSA Pharmaceuticals, Inc.

         Pursuant to the terms and subject to the conditions set forth in the
Nonqualified Stock Option Agreement (the "Agreement") dated October 21, 1997,
between DUSA Pharmaceuticals, Inc. and the undersigned, and the Option granted
to the undersigned by such Agreement, I hereby elect to purchase ____ shares of
Common Stock of DUSA Pharmaceuticals, Inc. which were the subject of such
Option. I understand that such purchase is subject to all the terms and
conditions of the Agreement. I request that the certificates for such shares of
Common Stock shall be issued in the name of:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

         The undersigned hereby represents and warrants to, and agrees with the
Company as follows:

         (a)      The shares are being purchased for the undersigned's own
account, for investment purposes only, and not for the account of any other
person, and not with a view to distribution, assignment, or resale to others, or
to fractionalization in whole or in part and that the offering and sale of the
shares is intended to be exempt from registration under the Securities Act of
1933 (the "Act"). In furtherance thereof, the undersigned represents, warrants
and agrees as follows: (i) no other person has or will have a direct or indirect
beneficial interest in such shares and the undersigned will not sell,
hypothecate, or otherwise transfer his shares except in accordance with the Act
and applicable state securities laws or unless in the opinion of counsel for the
Company, an exemption from the registration requirements of the Act and such
laws is available; and (ii) the Company is under no obligation to register the
shares on behalf of the undersigned or to assist the undersigned in complying
with any exemption from registration.


<PAGE>   17



         (b)      The undersigned has such knowledge and experience in financial
and business matters that the undersigned is capable of evaluating the merits
and risks of investment in the Company and of making an informed investment
decision.

         In full payment of the purchase price with respect to the Option
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian or
United States currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                 X
                         -------------------------------------
                                          (Signature)

                                 -------------------------------------------
                                          Name (Please Print)

                                 -------------------------------------------
                                          (Address)

                                 -------------------------------------------
                                          Taxpayer Identification Number



<PAGE>   1
                                                                 Exhibit 4.10(a)

                             STOCK OPTION AGREEMENT

         THIS AGREEMENT is made as of the 30th day of September, 1991 between
DEPRENYL USA, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and ROY H. POTTIER, PHD,
an individual residing at (hereinafter referred to as the "Participant").

         WITNESSETH:

         WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant an option to him to
purchase shares of the Company's common stock ("Shares") on the terms and
conditions set forth in this Agreement.

         NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:

1.1      DEFINITIONS

         In this Agreement:

         "Board of Directors" means the board of directors of the Company;

         "Exercise Price" means CDN. $6.79;

         "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later
         of the dates provided in Section 2.2;

         "Optioned Shares" means that number of Shares which are subject to the
         option granted by the Company to the Participant pursuant to this
         Agreement;

         "Services" means consulting or other services provided by the
         Participant to the Company, as requested from time to time by the Board
         of Directors, at its sole discretion; and

         "Shares" means shares of common stock, without par value, of the
         Company.


<PAGE>   2




2.1      GRANT OF OPTION

         The Company hereby grants to the Participant an option to purchase, in
         accordance with the vesting rights outlined in Sections 2.6 and 2.7
         hereof, up to 20,000 Shares for an amount per Share equal to the
         Exercise Price, upon the terms and subject to the conditions herein
         contained.

2.2      Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have
         the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on
         the fifth anniversary date hereof, being September 30, 1996 (provided
         that if such day is not a day on which the Company is open for business
         then on the first following day on which the Company is open for
         business) to exercise this option for any number of the Optioned Shares
         up to the maximum number of Shares specified in Section 2.1 above.

2.3      The option may be exercised by the Participant or by his executors or
         personal representatives in the circumstances described in Section 4.1
         by providing to the Company notice in writing in the form of Schedule A
         hereto setting out the number of Optioned Shares with respect to which
         the option is being exercised. The notice must be accompanied by a
         certified check, official bank cashier's check or money order in an
         amount equal to the Exercise Price multiplied by the number of Shares
         requested and a duly executed copy of this Agreement.

2.4      The Company shall cause its registrar and transfer agent to deliver to
         the Participant as soon as practicable after receipt of such notice and
         payment a certificate or certificates registered in the name of the
         Participant or as the Participant may direct for the number of Shares
         with respect to which the option is duly exercised.

2.5      Nothing contained in this Agreement or action taken pursuant hereto
         shall obligate the Participant to purchase and/or pay for, or the
         Company to issue, any Shares except those Optioned Shares with respect
         to which the Participant shall have duly exercised the option to
         purchase in accordance with this Agreement.

2.6      Subject to Section 2.7 hereof, the option granted hereunder shall vest
         in the following manner:

         (a)      one-quarter of the option on the first anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1992;

         (b)      one-quarter of the option on the second anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1993;

         (c)      one-quarter of the option on the third anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1994; and

         (d)      one-quarter of the option on the fourth anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1995;


                                       2
<PAGE>   3




         and, except as provided by Section 6.1, the Participant shall only be
         entitled to exercise this option in the amounts set out above and from
         and after the dates so specified.

2.7      Notwithstanding anything contained in Section 2.6 hereof, the option
         shall continue to vest only so long as the Participant continues to
         provide Services to the Company. Should the Participant cease to
         provide such Services ("Termination"), no further vesting of the option
         shall occur unless the Board of Directors determines otherwise and the
         provisions of Section 3.1 shall apply with respect to the exercise of
         the option to the extent that it has vested and has not yet been
         exercised.

3.1      EXPIRATION ON TERMINATION

         Subject to Section 4.1 hereof, upon Termination, such part of the
         option as is then vested but unexercised may be exercised by the
         Participant for a period of ninety (90) days after Termination or such
         later date as the Board of Directors may approve after which time this
         option shall expire; provided, however, that in no event may this
         option be exercised after the Expiration Date.

4.1      DEATH OR PERMANENT DISABILITY

         In the event that on or prior to the Expiration Date, the Participant
         dies or becomes totally and permanently disabled while providing
         Services to the Company, this option, to the extent then vested but
         unexercised, may be exercised by the Participant for a period up to six
         (6) months after the death or disability of the Participant; provided,
         however, that in no event may this option be exercised after the
         Expiration Date. Disability shall be defined as in Section 22(e)(3) of
         the Internal Revenue Code of 1986, as amended. For the purposes of this
         provision only, reference to the Participant in this Agreement shall be
         construed as including the executors or personal representatives of a
         deceased Participant. In the event that this option is not exercised
         within the period of six (6) months set out above, this option shall
         expire.

5.1      SUBDIVISION, CONSOLIDATION OR REORGANIZATION

         (a)      In the event of any subdivision, redivision or change of the
         Shares of the Company into a greater number of Shares at any time after
         the date of this Agreement and prior to the Expiration Date of this
         option, the Company shall deliver at the time of exercise of this
         option, but for the same aggregate consideration payable therefor, such
         additional number of Shares as the Participant would have been entitled
         to receive as a result of such subdivision, redivision or change if on
         the record date thereof the Participant had been the registered holder
         of the number of such Shares with respect to which the option is later
         exercised.

         (b)      In the event of any consolidation or change of the Shares of
         the Company into a lesser number of Shares at any time after the date
         of this Agreement and prior to the expiration of this option, the
         Company shall deliver at the time of exercise of this option, but for
         the same aggregate consideration payable therefor, such reduced number
         of Shares, as the Participant would have been entitled to receive upon
         such consolidation or change if on


                                       3
<PAGE>   4


         the record date thereof the Participant had been the registered holder
         of the number of such Shares with respect to which the option is later
         exercised.

         (c)      If at any time after the date of this Agreement and prior to
         the expiration of this option, the Shares shall be reclassified or
         reorganized, otherwise than as specified in Sections 5.1(a) and (b),
         the Participant shall be entitled to receive upon the exercise of this
         option and shall accept in lieu of the number of Shares then subscribed
         for, but for the same aggregate consideration payable therefor, the
         same aggregate number of shares of the appropriate class of shares that
         the Participant would have been entitled to receive as a result of such
         reclassification or other reorganization of Shares if on the record
         date thereof the Participant had been the registered holder of the
         number of such Shares with respect to which the option is later
         exercised.

6.1      TAKE-OVER BID

         If an offeror makes an offer to purchase 50% or more of the outstanding
         Shares to substantially all holders of the Shares or, if an insider of
         the Company makes an offer to purchase Shares to substantially all
         holders of the Shares, and the Board of Directors recommends acceptance
         of such offer to the shareholders of the Company and the offer price is
         greater than the Exercise Price, then this option, whether or not it
         has vested in whole or in part, shall become immediately exercisable.
         The Participant shall be bound to exercise this option and to tender
         the Optioned Shares issued upon exercise of this option into the offer
         upon receipt of notice from the Company if the Company provides an
         interest-free loan to the Participant in the amount of the Exercise
         Price for all of the Optioned Shares issuable upon exercise of this
         option, subject to the execution of a security agreement by the
         Participant in favor of the Company securing repayment of the loan.

7.1      NO ASSIGNMENT

         The Participant may not assign, transfer, pledge or hypothecate any of
         his rights hereunder in any way (whether by operation of law or
         otherwise) except by will or by the laws of succession on intestacy
         which may apply to the estate of the Participant upon his death. The
         option granted herein shall not be subject to execution, attachment or
         similar process. Upon any attempt to assign, transfer, pledge,
         hypothecate or otherwise dispose of this option contrary to the
         provisions hereof, or upon the levy of any attachment or similar
         process upon the option granted herein, such option shall immediately
         become void.

8.1      GENERAL

         (a)      Time shall be of the essence of this Agreement.

         (b)      In this Agreement, words importing the singular number include
         the plural and vice versa and words importing the masculine gender
         include the feminine and neuter genders.

         (c)      All notices which may be or are required to be given by one
         party to the other party pursuant to this Agreement shall be in writing
         and shall be mailed by first class or certified mail, return receipt
         requested, postage prepaid, or transmitted by hand delivery as follows:


                                       4
<PAGE>   5



         If to the Company:              Deprenyl USA, Inc.
                                         378 Roncesvalles Ave.
                                         Toronto, ON M6R 2M7
                                         CANADA

                                         Attention:  Dr. D. Geoffrey Shulman

                  with a copy to:        Nanette W. Mantell, Esq., Corporate
                                         Secretary
                                         Lane and Mantell
                                         991 Route 22 West
                                         PO Box 8539
                                         Somerville, NJ 08876
                                         U.S.A.

         If to the Participant:          at the address of the Participant from
                                         time to time in the records of the
                                         Company,

         or such other address as to which either party may from time to time
         notify the other as aforesaid.

9.1      RESTRICTIONS ON TRANSFER

         The Participant understands and acknowledges that the option and Shares
         underlying the option have not been registered and that they are
         subject to certain restrictions on transfer under the Securities Act of
         1933 of the United States, as amended, (the "1933 Act"); such
         restrictions provide that the Shares may not be sold without
         registration or exemption from registration under the 1933 Act; and,
         for purposes of the Securities Act (Ontario) (the "Ontario Act"), the
         first trade of the Shares issued pursuant to the exercise of the
         option, other than a trade exempted by the Ontario Act, will be a
         distribution unless the Company has been a reporting issuer for at
         least twelve (12) months and the Company is not in default of any
         requirement of the Ontario Act, disclosure has been made to the Ontario
         Securities Commission of the exempt trade, no unusual effort is made to
         prepare the market or create a demand for the Shares, and no
         extraordinary commission or consideration is paid with respect to the
         trade, provided that such first trade is not from the holdings of a
         so-called "control block".


                                       5
<PAGE>   6




         IN WITNESS WHEREOF, this Agreement has been duly executed by the
parties hereto.

Attest:                              DEPRENYL USA, INC.
                                     a New Jersey corporation

s/Edward L. Foster                   By: s/D. Geoffrey Shulman
- ----------------------------            -------------------------------------
Edward L. Foster, Treasurer               Dr. D. Geoffrey Shulman, President

                                     PARTICIPANT

                                     s/Roy H. Pottier
                                     --------------------------------------
                                     Roy H. Pottier, PhD


                                       6
<PAGE>   7





                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:      The Secretary of Deprenyl USA, Inc.

         Pursuant to the terms and subject to the conditions set forth in the
Stock Option Agreement (the "Agreement") dated      , between Deprenyl USA, Inc.
and the undersigned, I hereby elect to purchase      shares of Common Stock of
Deprenyl USA, Inc. I understand that such purchase is subject to all the terms
and conditions of the Agreement. I request that the certificates for such shares
of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

         In full payment of the purchase price with respect to the Optioned
Shares exercised, the undersigned hereby tenders payment of $___________ by
certified check or official bank cashier's check or money order payable in
Canadian currency to the order of Deprenyl USA, Inc.

Dated:                             X
                                     ---------------------------------
                                            (Signature)

                                            ------------------------------------
                                            Name (Please Print)

                                            ------------------------------------
                                            (Address)

                                            ------------------------------------
                                            Taxpayer Identification Number


<PAGE>   8

                                                                 Exhibit 4.10(b)

                       NONQUALIFIED STOCK OPTION AGREEMENT

         AGREEMENT made and entered into as of the 21ST day of OCTOBER, 1997, by
and between DUSA Pharmaceuticals, Inc., a corporation incorporated under the
laws of the State of New Jersey (the "Company"), and Roy H. Pottier, who resides
at 5 Huntsmill Cresent, Kingston, the "(Grantee").

         WHEREAS, the Company granted to PARTEQ RESEARCH AND DEVELOPMENT
INNOVATIONS, a corporation incorporated under the laws of Ontario, CANADA
("PARTEQ") on October 21, 1991 (the "Grant Date") stock options for 85,000
shares of the Company's common stock without par value ("Common Stock") in
connection with the agreement to amend a certain License Agreement dated August
27, 1991; and

         WHEREAS, PARTEQ has determined to assign a certain number of said
options to the Grantee in consideration of services rendered by him to the
Company; and

         WHEREAS, the Company has determined that its interests will be advanced
by acknowledging the assignment by PARTEQ of the options;

         NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, the parties agree as follows:

                                    SECTION 1
                                      GRANT

         1.1      The Company hereby acknowledges the assignment to the Grantee
                  of the right and option (the "Option") to purchase, in
                  accordance with the vesting rights outlined in Sections 3.1
                  and 3.6 hereof, up to 4,250 shares of authorized but unissued
                  Common Stock of the Company on the terms and conditions herein
                  set forth in this Nonqualified Stock Option Agreement.

                                    SECTION 2
                                      PRICE

         2.1      The purchase price of the shares of Common Stock subject to
                  this Option shall be the fair market value of the shares of
                  Common Stock on the Grant Date ($10.875 per share)(the
                  "Exercise Price").

                                    SECTION 3
                                WHEN EXERCISABLE

         3.1      The aggregate number of shares of Common Stock of the Company
                  optioned by this Agreement (the "Optioned Shares") shall vest
                  in the Grantee as follows:


<PAGE>   9





                  (a)      25% of the Option on the first anniversary of the day
                           of the grant, being October 21,1998;

                  (b)      25% of the Option on the second anniversary of the
                           day of grant, being October 21, 1999;

                  (c)      25% of the Option on the third anniversary of the day
                           of the grant, being October 21, 2000;

                  (d)      25% of the Option on the fourth anniversary of the
                           day of the grant, being October 21,2001; and

         and, except as provided by Sections 3.6 and 6.3 hereof, the Grantee
         shall only be entitled to exercise this Option, in whole or in part, in
         the amounts set out above and from and after the dates so specified.

         3.2      Subject to Sections 3.1 and 3.6 hereof, the Grantee shall have
                  the right, at any time prior to 5:00 p.m. (Eastern Standard
                  Time) on the date prior to the tenth anniversary date of the
                  grant, being October 20, 2007, provided that if such day is
                  not a day on which the Company is open for business then on
                  the first following day on which the Company is open for
                  business, to exercise this Option for any number of the
                  Optioned Shares up to the maximum number of shares specified
                  in Section 1.1 above.

         3.3      No less than one thousand (1,000) shares may be purchased upon
                  any one exercise of the Option granted hereby unless the
                  number of shares purchased at such time is the total number of
                  shares in respect of which the Option hereby granted is then
                  exercisable.

         3.4      In no event shall any Option granted hereby be exercisable for
                  a fractional share.

         3.5      From time to time, in its discretion, the Company's Stock
                  Option Committee (the "Committee") may offer the Grantee the
                  right to cancel any Option granted hereunder in exchange for
                  such consideration as the Committee shall determine.

         3.6      Notwithstanding anything contained in Sections 1 and 3.1
                  hereof, the Option shall continue to vest in the Grantee only
                  so long as the Grantee shall continue to provide services to
                  the Company. Should the Grantee cease to provide services to
                  the Company, the Option shall not further vest or become
                  exercisable.

                                    SECTION 4
                                 HOW EXERCISABLE

         4.1      Subject to such administrative regulations as the Committee
                  may from time to time adopt, the Grantee or beneficiary shall,
                  in order to exercise this Option give to the Company at its
                  principal office notice in writing in the form of Schedule A
                  hereto setting out the number of Optioned Shares with respect
                  to which the Option is being exercised. The notice must be
                  accompanied by payment of a certified check, official


                                       2
<PAGE>   10




                  bank cashier's check or money order in an amount equal to the
                  Exercise Price multiplied by the number of shares requested
                  and a duly executed copy of this Agreement. At the discretion
                  of the Committee, the Grantee may pay all or a portion of the
                  purchase price by tender of Common Stock or a combination of
                  stock and cash or other means determined by the Committee.

         4.2      Any notice under this Section shall include an undertaking to
                  furnish or execute such documents as the Committee in its
                  discretion shall deem necessary (i) to evidence such exercise,
                  in whole or in part, of the Option evidenced by this
                  Agreement, (ii) to determine whether registration is then
                  required under the Securities Act of 1933, or any other law,
                  as then in effect, and (iii) to comply with or satisfy the
                  requirements of the Securities Act of 1933, or any other law,
                  as then in effect.

         4.3      The Grantee agrees that all shares purchased by him under the
                  Option will be acquired for investment, not distribution, and
                  that any notice of exercise of the Option must be accompanied
                  by a written representation to that effect, signed by the
                  Grantee.

                                    SECTION 5
                              TERMINATION OF OPTION

         5.1      The Option granted hereby shall terminate and be of no force
                  or effect upon the expiration of ten years from the date of
                  the Grant unless terminated prior to such time as provided
                  below.

         5.2      Subject to Section 3.6, hereof if the Amended and Restated
                  License Agreement is terminated by PARTEQ, the Option may be
                  exercised, to the extent exercisable, for a period of three
                  months after the date of such termination or such later date
                  as the Company's Board of Directors may approve; and if such
                  Agreement is terminated by DUSA, the Option shall continue to
                  vest in the Grantee as provided in Section 3.1 above.

         5.3      Any determination made by the Committee with respect to any
                  matter referred to in this Section 5 shall be final and
                  conclusive on all persons affected thereby.

                                    SECTION 6
                              ADJUSTMENTS TO OPTION

         6.1      Subject to any required action by the Committee and
                  shareholders, the number of shares provided for in the Option,
                  and the price per share thereof shall be proportionately
                  adjusted for any increase or decrease in the number of issued
                  shares of the Company resulting from the payment of a share
                  dividend, a share split or any transaction which is a
                  "corporate transaction" (as defined in the Treasury
                  regulations promulgated under Section 424 of the Code.

         6.2      Subject to any required action by the Committee and
                  shareholders, if the Company shall be the surviving entity in
                  any merger or consolidation, or after a consolidation


                                       3
<PAGE>   11




                  of the Company and one or more entities in which the resulting
                  entity is an independent entity, the Option shall pertain to
                  and apply to the securities of the surviving entity in an
                  amount that the board of directors of the surviving entity, at
                  its sole discretion, determines to be equivalent, as nearly as
                  practicable, to the nearest whole number and class of shares
                  that were subject to the Option. These shares of stock or
                  other securities shall, after such merger or consolidation, be
                  deemed to be shares for all purposes hereof. The aforesaid
                  adjustments, when applicable, shall be made by the Committee,
                  and the Committee's determination shall be final, binding and
                  conclusive.

         6.3      In the event of a Change of Control (as defined below), any
                  and all outstanding Options not fully vested shall
                  automatically vest in full and shall be immediately
                  exercisable. The date on which such accelerated vesting and
                  immediate exercisability shall occur shall be the date of the
                  occurrence of the Change of Control.

                  A "Change of Control" shall be deemed to have taken place upon
                  (i) the acquisition by a third person, including a "group" as
                  defined in Section 13(d)(3) of the Securities Exchange Act of
                  1934, as amended, of shares of the Company having 50% or more
                  of the total number of votes that may be cast for the election
                  of Directors of the Company; (ii) shareholder approval of a
                  transaction for the acquisition of the Company, or
                  substantially all of its assets by another entity or for a
                  merger, reorganization, consolidation or other business
                  combination to which the Company is a part; or (iii) the
                  election during any period of 24 months or less of 50% or more
                  of the Directors of the Company where such Directors were not
                  in office immediately prior to such period provided, however,
                  that no "Change of Control" shall be deemed to have taken
                  place if the Directors of the Company in office on the date of
                  adoption of the Plan, or their successors in office nominated
                  by such Directors, affirmatively approve a resolution to such
                  effect.

                  Except as provided with respect to a Grantee in his stock
                  option agreement or other controlling agreement between him
                  and the Company, to the extent that the acceleration,
                  exercisability or parachute payment attributable to the Option
                  following a Change of Control would result in "excess
                  parachute payments"1 when the former are aggregated with other
                  payments or benefits to the Grantee, such parachute payments
                  or benefits provided to a Grantee under this Agreement shall
                  be reduced to the extent necessary so that no portion thereof
                  shall be subject to the excise tax imposed by Section 4999 of
                  the Code. This reduction will only be made if it will cause
                  the Grantee's net after-tax benefit to exceed the net
                  after-tax benefit that would have existed if such reduction
                  were not made. "Net after-tax benefit" shall be the sum of (i)
                  all payments and benefits which a Grantee receives or is
                  entitled to receive that would constitute a "parachute
                  payment" under Section 280G of the Code, less (ii) the amount
                  of federal income taxes payable with respect to the payments
                  and

- --------
     (1)"Excess parachute payments" are defined in Section 280G of the Code and
are determined by tax counsel of the Company.



                                       4
<PAGE>   12

                  benefits described in (i) above, calculated at the maximum
                  marginal income tax rate2 for the year in which such payments
                  and benefits shall be paid to the Grantee, less (iii) the
                  amount of excise taxes imposed with respect to the payments
                  and benefits described in (i) above by Section 4999 of the
                  Code.

         6.4      In the event of a change in the Company's shares which is
                  limited to a change of all of its authorized shares with par
                  value into the same number of shares with a different par
                  value or without par value, the shares resulting from any such
                  change shall be deemed to be shares within the meaning of this
                  Agreement.

         6.5      Except as herein before expressly provided in Paragraphs 6.1,
                  6.2, 6.3 and 6.4 of this Section 6, the Grantee shall have no
                  rights by reason of any subdivision or consolidation of shares
                  of any class or payment of any share dividend or any other
                  increase or decrease in the number of shares of any class or
                  by reason of any dissolution, liquidation, merger,
                  consolidation or spin-off of assets or stock of another
                  corporation and any issuance by the Company of shares of any
                  class, or securities convertible into shares of any class,
                  shall not affect the Option, and no adjustment by reason
                  thereof shall be made with respect to the number or price of
                  the Company's shares subject to the Option. The grant of the
                  Option shall not affect in any way the right or power of the
                  Company to make adjustments, reclassifications,
                  reorganizations or changes of its capital or business
                  structure or to merge, consolidate, dissolve, liquidate, sell
                  or transfer all or any part of its business or assets.

                                    SECTION 7
                                    TRANSFER

         7.1      This Option shall not be transferable by the Grantee in any
                  way. During the lifetime of the Grantee, the Option shall be
                  exercisable only by him. Any other attempted assignment,
                  transfer, pledge, hypothecation or other disposition of the
                  Option shall be void and have no effect unless in accordance
                  with the terms set forth herein.

                                    SECTION 8
                                WITHHOLDING TAXES

         8.1      The Company shall have the right to retain and withhold from
                  any payment, under the Option granted, any amount that is to
                  be withheld or otherwise deducted and paid with respect to
                  such payment. At its discretion, the Company may require the
                  Grantee, if it receives shares under a nonqualified stock
                  option grant, to reimburse the Company for any taxes that are
                  required to be withheld by the Company, and may withhold any
                  distribution in whole or in part until the Company is so
                  reimbursed. In lieu thereof, the Company shall have the right
                  to withhold from any other cash amounts due (or to become due)
                  to the Grantee an amount equal to such taxes required to be
                  withheld by the Company to reimburse the Company for any such

- ------------
     (2)"This rate is based on the rate for the year set forth in the Code at
the time of the first payment to the participant.



                                       5
<PAGE>   13


                  taxes, or the Company may retain and withhold a number of
                  shares of Common Stock having a market value not less than the
                  amount of such taxes and cancel (in whole or in part) any
                  shares of Common Stock so withheld in order to reimburse the
                  Company for any such taxes.

                                    SECTION 9
                            IMPACT ON OTHER BENEFITS

         9.1      The value of the Option (either on the date of grant of the
                  Option or at the time the shares are vested) shall not be
                  includable as compensation or earnings for purposes of any
                  other benefit plan offered by the Company.

                                   SECTION 10
                                 ADMINISTRATION

         10.1     The Committee shall have full authority and discretion to
                  decide all matters relating to the administration and
                  interpretation of this Agreement. All such Committee
                  determinations shall be final, conclusive and binding upon the
                  Company, the Grantee and any and all interested parties.

                                   SECTION 11
                                  AMENDMENT(S)

         11.1     This Agreement may not in any way be amended without the
                  Grantee's written consent.

                                   SECTION 12
                                FORCE AND EFFECT

         12.1     The various provisions of this Agreement are severable in
                  their entirety. Any determination of invalidity or
                  unenforceability of any one provision shall have no effect on
                  the continuing force and effect of the remaining provisions.

                                   SECTION 13
                         NOTICE OF DISPOSITION OF SHARES

         13.1     The Grantee agrees that if he should dispose of any shares of
                  Common Stock acquired on the exercise of the Option, including
                  a disposition by sale, exchange, gift or transfer of legal
                  title within twelve (12) months of the date such shares are
                  transferred to the Grantee, the Grantee will notify the
                  Company promptly of such disposition.


                                       6
<PAGE>   14




                                   SECTION 14
                                     NOTICES

         14.1     All notices which may be or are required to be given by one
                  party to the other party pursuant to this Agreement shall be
                  in writing and shall be mailed by first class or certified
                  mail, return receipt requested, postage prepaid, or
                  transmitted by hand delivery as follows:

                  If to the Company:        DUSA Pharmaceuticals, Inc.
                                            181 University Avenue
                                            Suite 1208
                                            Toronto, ON M5H 3M7
                                            CANADA

                                            Attention:  Dr. D. Geoffrey Shulman

                  If to the Grantee:        Roy H. Pottier

                  or such other address as to which either party may from time
                  to time notify the other as aforesaid.

                                   SECTION 15
                            RESTRICTIONS ON TRANSFER

         15.1     The Grantee understands and acknowledges that he is subject to
                  certain restrictions on transfer under the Securities Act of
                  1933 of the United States, as amended, (the "1933 Act") of the
                  shares issued pursuant to the exercise of the Option; such
                  restrictions provide that the shares may not be sold without
                  registration or exemption from registration under the 1933
                  Act.

                                   SECTION 16
                             REPORTING REQUIREMENTS

         16.1     The Grantee understands and acknowledges that he may be
                  subject to certain reporting requirements upon his receipt and
                  exercise of the Option, and in connection therewith, upon the
                  receipt and exercise of the Option, the Grantee agrees to
                  timely file with the Securities and Exchange Commission, the
                  National Association of Securities Dealers, Inc., and any
                  appropriate Canadian securities regulatory authorities, the
                  appropriate documentation regarding his ownership of the
                  Company's securities.


                                       7
<PAGE>   15




                                   SECTION 17
                                  GOVERNING LAW

         17.1     This Agreement shall be construed and enforced in accordance
                  with and governed by the laws of the State of New Jersey.

         IN WITNESS WHEREOF, this Agreement has been duly executed by the
parties hereto.

Attest:                                  DUSA PHARMACEUTICALS, INC.,
                                         a New Jersey corporation

s/Nanette W. Mantell                     By: s/D. Geoffrey Shulman
- ---------------------------------            ------------------------------
Nanette W. Mantell, Secretary                Dr. D. Geoffrey Shulman, President

                                         GRANTEE

                                             s/Roy H. Pottier
                                             ------------------------------
                                             Roy H. Pottier


                                       8
<PAGE>   16





                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:      The Secretary of DUSA Pharmaceuticals, Inc.

         Pursuant to the terms and subject to the conditions set forth in the
Nonqualified Stock Option Agreement (the "Agreement") dated October 21, 1997,
between DUSA Pharmaceuticals, Inc. and the undersigned, and the Option granted
to the undersigned by such Agreement, I hereby elect to purchase ____ shares of
Common Stock of DUSA Pharmaceuticals, Inc. which were the subject of such
Option. I understand that such purchase is subject to all the terms and
conditions of the Agreement. I request that the certificates for such shares of
Common Stock shall be issued in the name of:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

         The undersigned hereby represents and warrants to, and agrees with the
Company as follows:

         (a) The shares are being purchased for the undersigned's own account,
for investment purposes only, and not for the account of any other person, and
not with a view to distribution, assignment, or resale to others, or to
fractionalization in whole or in part and that the offering and sale of the
shares is intended to be exempt from registration under the Securities Act of
1933 (the "Act"). In furtherance thereof, the undersigned represents, warrants
and agrees as follows: (i) no other person has or will have a direct or indirect
beneficial interest in such shares and the undersigned will not sell,
hypothecate, or otherwise transfer his shares except in accordance with the Act
and applicable state securities laws or unless in the opinion of counsel for the
Company, an exemption from the registration requirements of the Act and such
laws is available; and (ii) the Company is under no obligation to register the
shares on behalf of the undersigned or to assist the undersigned in complying
with any exemption from registration.


<PAGE>   17





         (b) The undersigned has such knowledge and experience in financial and
business matters that the undersigned is capable of evaluating the merits and
risks of investment in the Company and of making an informed investment
decision.

         In full payment of the purchase price with respect to the Option
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian or
United States currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                    X
                           ----------------------------------
                                            (Signature)

                                   -----------------------------------
                                            Name (Please Print)

                                   -------------------------------------
                                            (Address)

                                   -------------------------------------
                                            Taxpayer Identification Number


<PAGE>   1
                                                                 Exhibit 4.11(a)

                             STOCK OPTION AGREEMENT

         THIS AGREEMENT is made as of the 30th day of September, 1991 between
DEPRENYL USA, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and ROBERT L. REID, MD, an
individual residing at (hereinafter referred to as the "Participant").

         WITNESSETH:

         WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant an option to him to
purchase shares of the Company's common stock ("Shares") on the terms and
conditions set forth in this Agreement.

         NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:

1.1      DEFINITIONS

         In this Agreement:

         "Board of Directors" means the board of directors of the Company;

         "Exercise Price" means CDN. $6.79;

         "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later
         of the dates provided in Section 2.2;

         "Optioned Shares" means that number of Shares which are subject to the
         option granted by the Company to the Participant pursuant to this
         Agreement;

         "Services" means consulting or other services provided by the
         Participant to the Company, as requested from time to time by the Board
         of Directors, at its sole discretion; and

         "Shares" means shares of common stock, without par value, of the
         Company.


<PAGE>   2




2.1      GRANT OF OPTION

         The Company hereby grants to the Participant an option to purchase, in
         accordance with the vesting rights outlined in Sections 2.6 and 2.7
         hereof, up to 20,000 Shares for an amount per Share equal to the
         Exercise Price, upon the terms and subject to the conditions herein
         contained.

2.2      Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have
         the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on
         the fifth anniversary date hereof, being September 30, 1996 (provided
         that if such day is not a day on which the Company is open for business
         then on the first following day on which the Company is open for
         business) to exercise this option for any number of the Optioned Shares
         up to the maximum number of Shares specified in Section 2.1 above.

2.3      The option may be exercised by the Participant or by his executors or
         personal representatives in the circumstances described in Section 4.1
         by providing to the Company notice in writing in the form of Schedule A
         hereto setting out the number of Optioned Shares with respect to which
         the option is being exercised. The notice must be accompanied by a
         certified check, official bank cashier's check or money order in an
         amount equal to the Exercise Price multiplied by the number of Shares
         requested and a duly executed copy of this Agreement.

2.4      The Company shall cause its registrar and transfer agent to deliver to
         the Participant as soon as practicable after receipt of such notice and
         payment a certificate or certificates registered in the name of the
         Participant or as the Participant may direct for the number of Shares
         with respect to which the option is duly exercised.

2.5      Nothing contained in this Agreement or action taken pursuant hereto
         shall obligate the Participant to purchase and/or pay for, or the
         Company to issue, any Shares except those Optioned Shares with respect
         to which the Participant shall have duly exercised the option to
         purchase in accordance with this Agreement.

2.6      Subject to Section 2.7 hereof, the option granted hereunder shall vest
         in the following manner:

         (a)      one-quarter of the option on the first anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1992;

         (b)      one-quarter of the option on the second anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1993;

         (c)      one-quarter of the option on the third anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1994; and

         (d)      one-quarter of the option on the fourth anniversary of the day
                  immediately preceding the date hereof, being September 29,
                  1995;


                                       2
<PAGE>   3




         and, except as provided by Section 6.1, the Participant shall only be
         entitled to exercise this option in the amounts set out above and from
         and after the dates so specified.

2.7      Notwithstanding anything contained in Section 2.6 hereof, the option
         shall continue to vest only so long as the Participant continues to
         provide Services to the Company. Should the Participant cease to
         provide such Services ("Termination"), no further vesting of the option
         shall occur unless the Board of Directors determines otherwise and the
         provisions of Section 3.1 shall apply with respect to the exercise of
         the option to the extent that it has vested and has not yet been
         exercised.

3.1      EXPIRATION ON TERMINATION

         Subject to Section 4.1 hereof, upon Termination, such part of the
         option as is then vested but unexercised may be exercised by the
         Participant for a period of ninety (90) days after Termination or such
         later date as the Board of Directors may approve after which time this
         option shall expire; provided, however, that in no event may this
         option be exercised after the Expiration Date.

4.1      DEATH OR PERMANENT DISABILITY

         In the event that on or prior to the Expiration Date, the Participant
         dies or becomes totally and permanently disabled while providing
         Services to the Company, this option, to the extent then vested but
         unexercised, may be exercised by the Participant for a period up to six
         (6) months after the death or disability of the Participant; provided,
         however, that in no event may this option be exercised after the
         Expiration Date. Disability shall be defined as in Section 22(e)(3) of
         the Internal Revenue Code of 1986, as amended. For the purposes of this
         provision only, reference to the Participant in this Agreement shall be
         construed as including the executors or personal representatives of a
         deceased Participant. In the event that this option is not exercised
         within the period of six (6) months set out above, this option shall
         expire.

5.1      SUBDIVISION, CONSOLIDATION OR REORGANIZATION

         (a)      In the event of any subdivision, redivision or change of the
         Shares of the Company into a greater number of Shares at any time after
         the date of this Agreement and prior to the Expiration Date of this
         option, the Company shall deliver at the time of exercise of this
         option, but for the same aggregate consideration payable therefor, such
         additional number of Shares as the Participant would have been entitled
         to receive as a result of such subdivision, redivision or change if on
         the record date thereof the Participant had been the registered holder
         of the number of such Shares with respect to which the option is later
         exercised.

         (b)      In the event of any consolidation or change of the Shares of
         the Company into a lesser number of Shares at any time after the date
         of this Agreement and prior to the expiration of this option, the
         Company shall deliver at the time of exercise of this option, but for
         the same aggregate consideration payable therefor, such reduced number
         of Shares, as the Participant would have been entitled to receive upon
         such consolidation or change if on


                                       3
<PAGE>   4


         the record date thereof the Participant had been the registered holder
         of the number of such Shares with respect to which the option is later
         exercised.

         (c)      If at any time after the date of this Agreement and prior to
         the expiration of this option, the Shares shall be reclassified or
         reorganized, otherwise than as specified in Sections 5.1(a) and (b),
         the Participant shall be entitled to receive upon the exercise of this
         option and shall accept in lieu of the number of Shares then subscribed
         for, but for the same aggregate consideration payable therefor, the
         same aggregate number of shares of the appropriate class of shares that
         the Participant would have been entitled to receive as a result of such
         reclassification or other reorganization of Shares if on the record
         date thereof the Participant had been the registered holder of the
         number of such Shares with respect to which the option is later
         exercised.

6.1      TAKE-OVER BID

         If an offeror makes an offer to purchase 50% or more of the outstanding
         Shares to substantially all holders of the Shares or, if an insider of
         the Company makes an offer to purchase Shares to substantially all
         holders of the Shares, and the Board of Directors recommends acceptance
         of such offer to the shareholders of the Company and the offer price is
         greater than the Exercise Price, then this option, whether or not it
         has vested in whole or in part, shall become immediately exercisable.
         The Participant shall be bound to exercise this option and to tender
         the Optioned Shares issued upon exercise of this option into the offer
         upon receipt of notice from the Company if the Company provides an
         interest-free loan to the Participant in the amount of the Exercise
         Price for all of the Optioned Shares issuable upon exercise of this
         option, subject to the execution of a security agreement by the
         Participant in favor of the Company securing repayment of the loan.

7.1      NO ASSIGNMENT

         The Participant may not assign, transfer, pledge or hypothecate any of
         his rights hereunder in any way (whether by operation of law or
         otherwise) except by will or by the laws of succession on intestacy
         which may apply to the estate of the Participant upon his death. The
         option granted herein shall not be subject to execution, attachment or
         similar process. Upon any attempt to assign, transfer, pledge,
         hypothecate or otherwise dispose of this option contrary to the
         provisions hereof, or upon the levy of any attachment or similar
         process upon the option granted herein, such option shall immediately
         become void.

8.1      GENERAL

         (a)      Time shall be of the essence of this Agreement.

         (b)      In this Agreement, words importing the singular number include
         the plural and vice versa and words importing the masculine gender
         include the feminine and neuter genders.

         (c)      All notices which may be or are required to be given by one
         party to the other party pursuant to this Agreement shall be in writing
         and shall be mailed by first class or certified mail, return receipt
         requested, postage prepaid, or transmitted by hand delivery as follows:


                                       4
<PAGE>   5

<TABLE>

        <S>                            <C>
         If to the Company:             Deprenyl USA, Inc.
                                        378 Roncesvalles Ave.
                                        Toronto, ON M6R 2M7
                                        CANADA

                                        Attention:  Dr. D. Geoffrey Shulman

                  with a copy to:       Nanette W. Mantell, Esq., Corporate
                                        Secretary
                                        Lane and Mantell
                                        991 Route 22 West
                                        PO Box 8539
                                        Somerville, NJ 08876
                                        U.S.A.

         If to the Participant:         at the address of the Participant from
                                        time to time in the records of the
                                        Company,
</TABLE>

         or such other address as to which either party may from time to time
         notify the other as aforesaid.

9.1      RESTRICTIONS ON TRANSFER

         The Participant understands and acknowledges that the option and Shares
         underlying the option have not been registered and that they are
         subject to certain restrictions on transfer under the Securities Act of
         1933 of the United States, as amended, (the "1933 Act"); such
         restrictions provide that the Shares may not be sold without
         registration or exemption from registration under the 1933 Act; and,
         for purposes of the Securities Act (Ontario) (the "Ontario Act"), the
         first trade of the Shares issued pursuant to the exercise of the
         option, other than a trade exempted by the Ontario Act, will be a
         distribution unless the Company has been a reporting issuer for at
         least twelve (12) months and the Company is not in default of any
         requirement of the Ontario Act, disclosure has been made to the Ontario
         Securities Commission of the exempt trade, no unusual effort is made to
         prepare the market or create a demand for the Shares, and no
         extraordinary commission or consideration is paid with respect to the
         trade, provided that such first trade is not from the holdings of a
         so-called "control block".


                                       5
<PAGE>   6




         IN WITNESS WHEREOF, this Agreement has been duly executed by the
parties hereto.

Attest:                                  DEPRENYL USA, INC.
                                         a New Jersey corporation

s/Edward L. Foster                       By: s/D. Geoffrey Shulman
- ----------------------------                 -----------------------------------
Edward L. Foster, Treasurer                   Dr. D. Geoffrey Shulman, President

                                         PARTICIPANT

                                         s/Robert L. Reid
                                         --------------------------------
                                         Robert L. Reid, MD


                                       6
<PAGE>   7





                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:      The Secretary of Deprenyl USA, Inc.

         Pursuant to the terms and subject to the conditions set forth in the
Stock Option Agreement (the "Agreement") dated     , between Deprenyl USA, Inc.
and the undersigned, I hereby elect to purchase      shares of Common Stock of
Deprenyl USA, Inc. I understand that such purchase is subject to all the terms
and conditions of the Agreement. I request that the certificates for such shares
of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

         In full payment of the purchase price with respect to the Optioned
Shares exercised, the undersigned hereby tenders payment of $___________ by
certified check or official bank cashier's check or money order payable in
Canadian currency to the order of Deprenyl USA, Inc.

Dated:                              X
                                      ------------------------------
                                             (Signature)

                                             -----------------------------------
                                             Name (Please Print)

                                             -----------------------------------
                                             (Address)

                                             -----------------------------------
                                             Taxpayer Identification Number

<PAGE>   8

                                                                 Exhibit 4.11(b)

                       NONQUALIFIED STOCK OPTION AGREEMENT

         AGREEMENT made and entered into as of the 21ST day of OCTOBER, 1997, by
and between DUSA Pharmaceuticals, Inc., a corporation incorporated under the
laws of the State of New Jersey (the "Company"), and Robert L. Reid, who resides
at 5 Concord Drive, Kingston Ontairo K7L 4V1, the "(Grantee").

         WHEREAS, the Company granted to PARTEQ RESEARCH AND DEVELOPMENT
INNOVATIONS, a corporation incorporated under the laws of Ontario, CANADA
("PARTEQ") on October 21, 1991 (the "Grant Date") stock options for 85,000
shares of the Company's common stock without par value ("Common Stock") in
connection with the agreement to amend a certain License Agreement dated August
27, 1991; and

         WHEREAS, PARTEQ has determined to assign a certain number of said
options to the Grantee in consideration of services rendered by him to the
Company; and

         WHEREAS, the Company has determined that its interests will be advanced
by acknowledging the assignment by PARTEQ of the options;

         NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, the parties agree as follows:

                                    SECTION 1
                                      GRANT

         1.1      The Company hereby acknowledges the assignment to the Grantee
                  of the right and option (the "Option") to purchase, in
                  accordance with the vesting rights outlined in Sections 3.1
                  and 3.6 hereof, up to 6,800 shares of authorized but unissued
                  Common Stock of the Company on the terms and conditions herein
                  set forth in this Nonqualified Stock Option Agreement.

                                    SECTION 2
                                      PRICE

         2.1      The purchase price of the shares of Common Stock subject to
                  this Option shall be the fair market value of the shares of
                  Common Stock on the Grant Date ($10.875 per share)(the
                  "Exercise Price").

                                    SECTION 3
                                WHEN EXERCISABLE

         3.1      The aggregate number of shares of Common Stock of the Company
                  optioned by this Agreement (the "Optioned Shares") shall vest
                  in the Grantee as follows:


<PAGE>   9





                  (a)      25% of the Option on the first anniversary of the day
                           of the grant, being October 21, 1998;

                  (b)      25% of the Option on the second anniversary of the
                           day of grant, being October 21, 1999;

                  (c)      25% of the Option on the third anniversary of the day
                           of the grant, being October 21, 2000;

                  (d)      25% of the Option on the fourth anniversary of the
                           day of the grant, being October 21,2001; and

         and, except as provided by Sections 3.6 and 6.3 hereof, the Grantee
         shall only be entitled to exercise this Option, in whole or in part, in
         the amounts set out above and from and after the dates so specified.

         3.2      Subject to Sections 3.1 and 3.6 hereof, the Grantee shall have
                  the right, at any time prior to 5:00 p.m. (Eastern Standard
                  Time) on the date prior to the tenth anniversary date of the
                  grant, being October 20, 2007, provided that if such day is
                  not a day on which the Company is open for business then on
                  the first following day on which the Company is open for
                  business, to exercise this Option for any number of the
                  Optioned Shares up to the maximum number of shares specified
                  in Section 1.1 above.

         3.3      No less than one thousand (1,000) shares may be purchased upon
                  any one exercise of the Option granted hereby unless the
                  number of shares purchased at such time is the total number of
                  shares in respect of which the Option hereby granted is then
                  exercisable.

         3.4      In no event shall any Option granted hereby be exercisable for
                  a fractional share.

         3.5      From time to time, in its discretion, the Company's Stock
                  Option Committee (the "Committee") may offer the Grantee the
                  right to cancel any Option granted hereunder in exchange for
                  such consideration as the Committee shall determine.

         3.6      Notwithstanding anything contained in Sections 1 and 3.1
                  hereof, the Option shall continue to vest in the Grantee only
                  so long as the Grantee shall continue to provide services to
                  the Company. Should the Grantee cease to provide services to
                  the Company, the Option shall not further vest or become
                  exercisable.

                                    SECTION 4
                                 HOW EXERCISABLE

         4.1      Subject to such administrative regulations as the Committee
                  may from time to time adopt, the Grantee or beneficiary shall,
                  in order to exercise this Option give to the Company at its
                  principal office notice in writing in the form of Schedule A
                  hereto setting out the number of Optioned Shares with respect
                  to which the Option is being exercised. The notice must be
                  accompanied by payment of a certified check, official



                                       2
<PAGE>   10


                  bank cashier's check or money order in an amount equal to the
                  Exercise Price multiplied by the number of shares requested
                  and a duly executed copy of this Agreement. At the discretion
                  of the Committee, the Grantee may pay all or a portion of the
                  purchase price by tender of Common Stock or a combination of
                  stock and cash or other means determined by the Committee.

         4.2      Any notice under this Section shall include an undertaking to
                  furnish or execute such documents as the Committee in its
                  discretion shall deem necessary (i) to evidence such exercise,
                  in whole or in part, of the Option evidenced by this
                  Agreement, (ii) to determine whether registration is then
                  required under the Securities Act of 1933, or any other law,
                  as then in effect, and (iii) to comply with or satisfy the
                  requirements of the Securities Act of 1933, or any other law,
                  as then in effect.

         4.3      The Grantee agrees that all shares purchased by him under the
                  Option will be acquired for investment, not distribution, and
                  that any notice of exercise of the Option must be accompanied
                  by a written representation to that effect, signed by the
                  Grantee.

                                    SECTION 5
                              TERMINATION OF OPTION

         5.1      The Option granted hereby shall terminate and be of no force
                  or effect upon the expiration of ten years from the date of
                  the Grant unless terminated prior to such time as provided
                  below.

         5.2      Subject to Section 3.6, hereof if the Amended and Restated
                  License Agreement is terminated by PARTEQ, the Option may be
                  exercised, to the extent exercisable, for a period of three
                  months after the date of such termination or such later date
                  as the Company's Board of Directors may approve; and if such
                  Agreement is terminated by DUSA, the Option shall continue to
                  vest in the Grantee as provided in Section 3.1 above.

         5.3      Any determination made by the Committee with respect to any
                  matter referred to in this Section 5 shall be final and
                  conclusive on all persons affected thereby.

                                    SECTION 6
                              ADJUSTMENTS TO OPTION

         6.1      Subject to any required action by the Committee and
                  shareholders, the number of shares provided for in the Option,
                  and the price per share thereof shall be proportionately
                  adjusted for any increase or decrease in the number of issued
                  shares of the Company resulting from the payment of a share
                  dividend, a share split or any transaction which is a
                  "corporate transaction" (as defined in the Treasury
                  regulations promulgated under Section 424 of the Code.

         6.2      Subject to any required action by the Committee and
                  shareholders, if the Company shall be the surviving entity in
                  any merger or consolidation, or after a consolidation


                                       3
<PAGE>   11



                  of the Company and one or more entities in which the resulting
                  entity is an independent entity, the Option shall pertain to
                  and apply to the securities of the surviving entity in an
                  amount that the board of directors of the surviving entity, at
                  its sole discretion, determines to be equivalent, as nearly as
                  practicable, to the nearest whole number and class of shares
                  that were subject to the Option. These shares of stock or
                  other securities shall, after such merger or consolidation, be
                  deemed to be shares for all purposes hereof. The aforesaid
                  adjustments, when applicable, shall be made by the Committee,
                  and the Committee's determination shall be final, binding and
                  conclusive.

         6.3      In the event of a Change of Control (as defined below), any
                  and all outstanding Options not fully vested shall
                  automatically vest in full and shall be immediately
                  exercisable. The date on which such accelerated vesting and
                  immediate exercisability shall occur shall be the date of the
                  occurrence of the Change of Control.

                  A "Change of Control" shall be deemed to have taken place upon
                  (i) the acquisition by a third person, including a "group" as
                  defined in Section 13(d)(3) of the Securities Exchange Act of
                  1934, as amended, of shares of the Company having 50% or more
                  of the total number of votes that may be cast for the election
                  of Directors of the Company; (ii) shareholder approval of a
                  transaction for the acquisition of the Company, or
                  substantially all of its assets by another entity or for a
                  merger, reorganization, consolidation or other business
                  combination to which the Company is a part; or (iii) the
                  election during any period of 24 months or less of 50% or more
                  of the Directors of the Company where such Directors were not
                  in office immediately prior to such period provided, however,
                  that no "Change of Control" shall be deemed to have taken
                  place if the Directors of the Company in office on the date of
                  adoption of the Plan, or their successors in office nominated
                  by such Directors, affirmatively approve a resolution to such
                  effect.

                  Except as provided with respect to a Grantee in his stock
                  option agreement or other controlling agreement between him
                  and the Company, to the extent that the acceleration,
                  exercisability or parachute payment attributable to the Option
                  following a Change of Control would result in "excess
                  parachute payments"(1) when the former are aggregated with
                  other payments or benefits to the Grantee, such parachute
                  payments or benefits provided to a Grantee under this
                  Agreement shall be reduced to the extent necessary so that no
                  portion thereof shall be subject to the excise tax imposed by
                  Section 4999 of the Code. This reduction will only be made if
                  it will cause the Grantee's net after-tax benefit to exceed
                  the net after-tax benefit that would have existed if such
                  reduction were not made. "Net after-tax benefit" shall be the
                  sum of (i) all payments and benefits which a Grantee receives
                  or is entitled to receive that would constitute a "parachute
                  payment" under Section 280G of the Code, less (ii) the amount
                  of federal income taxes payable with respect to the payments
                  and


- --------
     (1)"Excess parachute payments" are defined in Section 280G of the Code and
are determined by tax counsel of the Company.


                                       4
<PAGE>   12



                  benefits described in (i) above, calculated at the maximum
                  marginal income tax rate(2) for the year in which such
                  payments and benefits shall be paid to the Grantee, less (iii)
                  the amount of excise taxes imposed with respect to the
                  payments and benefits described in (i) above by Section 4999
                  of the Code.

         6.4      In the event of a change in the Company's shares which is
                  limited to a change of all of its authorized shares with par
                  value into the same number of shares with a different par
                  value or without par value, the shares resulting from any such
                  change shall be deemed to be shares within the meaning of this
                  Agreement.

         6.5      Except as herein before expressly provided in Paragraphs 6.1,
                  6.2, 6.3 and 6.4 of this Section 6, the Grantee shall have no
                  rights by reason of any subdivision or consolidation of shares
                  of any class or payment of any share dividend or any other
                  increase or decrease in the number of shares of any class or
                  by reason of any dissolution, liquidation, merger,
                  consolidation or spin-off of assets or stock of another
                  corporation and any issuance by the Company of shares of any
                  class, or securities convertible into shares of any class,
                  shall not affect the Option, and no adjustment by reason
                  thereof shall be made with respect to the number or price of
                  the Company's shares subject to the Option. The grant of the
                  Option shall not affect in any way the right or power of the
                  Company to make adjustments, reclassifications,
                  reorganizations or changes of its capital or business
                  structure or to merge, consolidate, dissolve, liquidate, sell
                  or transfer all or any part of its business or assets.

                                    SECTION 7
                                    TRANSFER

         7.1      This Option shall not be transferable by the Grantee in any
                  way. During the lifetime of the Grantee, the Option shall be
                  exercisable only by him. Any other attempted assignment,
                  transfer, pledge, hypothecation or other disposition of the
                  Option shall be void and have no effect unless in accordance
                  with the terms set forth herein.

                                    SECTION 8
                                WITHHOLDING TAXES

         8.1      The Company shall have the right to retain and withhold from
                  any payment, under the Option granted, any amount that is to
                  be withheld or otherwise deducted and paid with respect to
                  such payment. At its discretion, the Company may require the
                  Grantee, if it receives shares under a nonqualified stock
                  option grant, to reimburse the Company for any taxes that are
                  required to be withheld by the Company, and may withhold any
                  distribution in whole or in part until the Company is so
                  reimbursed. In lieu thereof, the Company shall have the right
                  to withhold from any other cash amounts due (or to become due)
                  to the Grantee an amount equal to such taxes required to be
                  withheld by the Company to reimburse the Company for any such

- ------------------------
     (2)"This rate is based on the rate for the year set forth in the Code at
the time of the first payment to the participant.


                                       5
<PAGE>   13



                  taxes, or the Company may retain and withhold a number of
                  shares of Common Stock having a market value not less than the
                  amount of such taxes and cancel (in whole or in part) any
                  shares of Common Stock so withheld in order to reimburse the
                  Company for any such taxes.

                                    SECTION 9
                            IMPACT ON OTHER BENEFITS

         9.1      The value of the Option (either on the date of grant of the
                  Option or at the time the shares are vested) shall not be
                  includable as compensation or earnings for purposes of any
                  other benefit plan offered by the Company.

                                   SECTION 10
                                 ADMINISTRATION

         10.1     The Committee shall have full authority and discretion to
                  decide all matters relating to the administration and
                  interpretation of this Agreement. All such Committee
                  determinations shall be final, conclusive and binding upon the
                  Company, the Grantee and any and all interested parties.

                                   SECTION 11
                                  AMENDMENT(S)

         11.1     This Agreement may not in any way be amended without the
                  Grantee's written consent.

                                   SECTION 12
                                FORCE AND EFFECT

         12.1     The various provisions of this Agreement are severable in
                  their entirety. Any determination of invalidity or
                  unenforceability of any one provision shall have no effect on
                  the continuing force and effect of the remaining provisions.

                                   SECTION 13
                         NOTICE OF DISPOSITION OF SHARES

         13.1     The Grantee agrees that if he should dispose of any shares of
                  Common Stock acquired on the exercise of the Option, including
                  a disposition by sale, exchange, gift or transfer of legal
                  title within twelve (12) months of the date such shares are
                  transferred to the Grantee, the Grantee will notify the
                  Company promptly of such disposition.


                                       6
<PAGE>   14


                                   SECTION 14
                                     NOTICES

         14.1     All notices which may be or are required to be given by one
                  party to the other party pursuant to this Agreement shall be
                  in writing and shall be mailed by first class or certified
                  mail, return receipt requested, postage prepaid, or
                  transmitted by hand delivery as follows:

                  If to the Company:        DUSA Pharmaceuticals, Inc.
                                            181 University Avenue
                                            Suite 1208
                                            Toronto, ON M5H 3M7
                                            CANADA

                                            Attention:  Dr. D. Geoffrey Shulman

                  If to the Grantee:        Robert L. Reid

                  or such other address as to which either party may from time
                  to time notify the other as aforesaid.

                                   SECTION 15
                            RESTRICTIONS ON TRANSFER

         15.1     The Grantee understands and acknowledges that he is subject to
                  certain restrictions on transfer under the Securities Act of
                  1933 of the United States, as amended, (the "1933 Act") of the
                  shares issued pursuant to the exercise of the Option; such
                  restrictions provide that the shares may not be sold without
                  registration or exemption from registration under the 1933
                  Act.

                                   SECTION 16
                             REPORTING REQUIREMENTS

         16.1     The Grantee understands and acknowledges that he may be
                  subject to certain reporting requirements upon his receipt and
                  exercise of the Option, and in connection therewith, upon the
                  receipt and exercise of the Option, the Grantee agrees to
                  timely file with the Securities and Exchange Commission, the
                  National Association of Securities Dealers, Inc., and any
                  appropriate Canadian securities regulatory authorities, the
                  appropriate documentation regarding his ownership of the
                  Company's securities.


                                       7
<PAGE>   15




                                   SECTION 17
                                  GOVERNING LAW

         17.1     This Agreement shall be construed and enforced in accordance
                  with and governed by the laws of the State of New Jersey.

         IN WITNESS WHEREOF, this Agreement has been duly executed by the
parties hereto.

Attest:                                  DUSA PHARMACEUTICALS, INC.,
                                         a New Jersey corporation

s/ Nanette W. Mantell                    By: s/ D. Geoffrey Shulman
- --------------------------------           --------------------------------
Nanette W. Mantell, Secretary                Dr. D. Geoffrey Shulman, President

                                         GRANTEE

                                             s/Robert L. Reid
                                             ----------------------------
                                             Robert L. Reid


                                       8
<PAGE>   16





                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:      The Secretary of DUSA Pharmaceuticals, Inc.

         Pursuant to the terms and subject to the conditions set forth in the
Nonqualified Stock Option Agreement (the "Agreement") dated October 21, 1997,
between DUSA Pharmaceuticals, Inc. and the undersigned, and the Option granted
to the undersigned by such Agreement, I hereby elect to purchase ____ shares of
Common Stock of DUSA Pharmaceuticals, Inc. which were the subject of such
Option. I understand that such purchase is subject to all the terms and
conditions of the Agreement. I request that the certificates for such shares of
Common Stock shall be issued in the name of:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

         The undersigned hereby represents and warrants to, and agrees with the
Company as follows:

         (a)      The shares are being purchased for the undersigned's own
account, for investment purposes only, and not for the account of any other
person, and not with a view to distribution, assignment, or resale to others, or
to fractionalization in whole or in part and that the offering and sale of the
shares is intended to be exempt from registration under the Securities Act of
1933 (the "Act"). In furtherance thereof, the undersigned represents, warrants
and agrees as follows: (i) no other person has or will have a direct or indirect
beneficial interest in such shares and the undersigned will not sell,
hypothecate, or otherwise transfer his shares except in accordance with the Act
and applicable state securities laws or unless in the opinion of counsel for the
Company, an exemption from the registration requirements of the Act and such
laws is available; and (ii) the Company is under no obligation to register the
shares on behalf of the undersigned or to assist the undersigned in complying
with any exemption from registration.


<PAGE>   17






         (b)      The undersigned has such knowledge and experience in financial
and business matters that the undersigned is capable of evaluating the merits
and risks of investment in the Company and of making an informed investment
decision.

         In full payment of the purchase price with respect to the Option
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian or
United States currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                          X
                                  --------------------------------
                                                  (Signature)

                                         -----------------------------------
                                                  Name (Please Print)

                                         -------------------------------------
                                                  (Address)

                                         -------------------------------------
                                                  Taxpayer Identification Number


<PAGE>   1
                                                                    Exhibit 4.12

                       NONQUALIFIED STOCK OPTION AGREEMENT

        AGREEMENT made and entered into as of the 21ST day of OCTOBER, 1997, by
and between DUSA Pharmaceuticals, Inc., a corporation incorporated under the
laws of the State of New Jersey (the "Company"), and Dean Van Vugt, who resides
at 9 Faircrest Blvd. Kingston, the "(Grantee").

        WHEREAS, the Company granted to PARTEQ RESEARCH AND DEVELOPMENT
INNOVATIONS, a corporation incorporated under the laws of Ontario, CANADA
("PARTEQ") on October 21, 1991 (the "Grant Date") stock options for 85,000
shares of the Company's common stock without par value ("Common Stock") in
connection with the agreement to amend a certain License Agreement dated August
27, 1991; and

        WHEREAS, PARTEQ has determined to assign a certain number of said
options to the Grantee in consideration of services rendered by him to the
Company; and

        WHEREAS, the Company has determined that its interests will be advanced
by acknowledging the assignment by PARTEQ of the options;

        NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, the parties agree as follows:

                                    SECTION 1
                                      GRANT

        1.1    The Company hereby acknowledges the assignment to the Grantee of
               the right and option (the "Option") to purchase, in accordance
               with the vesting rights outlined in Sections 3.1 and 3.6 hereof,
               up to 2,261 shares of authorized but unissued Common Stock of the
               Company on the terms and conditions herein set forth in this
               Nonqualified Stock Option Agreement.

                                    SECTION 2
                                      PRICE

        2.1    The purchase price of the shares of Common Stock subject to this
               Option shall be the fair market value of the shares of Common
               Stock on the Grant Date ($10.875 per share)(the "Exercise
               Price").

                                    SECTION 3
                                WHEN EXERCISABLE

        3.1    The aggregate number of shares of Common Stock of the Company
               optioned by this Agreement (the "Optioned Shares") shall vest in
               the Grantee as follows:


<PAGE>   2


               (a)     25% of the Option on the first anniversary of the day of
                       the grant, being October 21, 1998;

               (b)     25% of the Option on the second anniversary of the day
                       of grant, being October 21, 1999;

               (c)     25% of the Option on the third anniversary of the day of
                       the grant, being October 21, 2000;

               (d)     25% of the Option on the fourth anniversary of the day
                       of the grant, being October 21,2001; and

        and, except as provided by Sections 3.6 and 6.3 hereof, the Grantee
        shall only be entitled to exercise this Option, in whole or in part, in
        the amounts set out above and from and after the dates so specified.

        3.2    Subject to Sections 3.1 and 3.6 hereof, the Grantee shall have
               the right, at any time prior to 5:00 p.m. (Eastern Standard
               Time) on the date prior to the tenth anniversary date of the
               grant, being October 20, 2007, provided that if such day is not
               a day on which the Company is open for business then on the
               first following day on which the Company is open for business,
               to exercise this Option for any number of the Optioned Shares up
               to the maximum number of shares specified in Section 1.1 above.

        3.3    No less than one thousand (1,000) shares may be purchased upon
               any one exercise of the Option granted hereby unless the number
               of shares purchased at such time is the total number of shares in
               respect of which the Option hereby granted is then exercisable.

        3.4    In no event shall any Option granted hereby be exercisable for a
               fractional share.

        3.5    From time to time, in its discretion, the Company's Stock Option
               Committee (the "Committee") may offer the Grantee the right to
               cancel any Option granted hereunder in exchange for such
               consideration as the Committee shall determine.

        3.6    Notwithstanding anything contained in Sections 1 and 3.1 hereof,
               the Option shall continue to vest in the Grantee only so long as
               the Grantee shall continue to provide services to the Company.
               Should the Grantee cease to provide services to the Company, the
               Option shall not further vest or become exercisable.

                                    SECTION 4
                                 HOW EXERCISABLE

        4.1    Subject to such administrative regulations as the Committee may
               from time to time adopt, the Grantee or beneficiary shall, in
               order to exercise this Option give to the Company at its
               principal office notice in writing in the form of Schedule A
               hereto setting out the number of Optioned Shares with respect to
               which the Option is being exercised. The notice must be
               accompanied by payment of a certified check, official




                                       2
<PAGE>   3

               bank cashier's check or money order in an amount equal to the
               Exercise Price multiplied by the number of shares requested and a
               duly executed copy of this Agreement. At the discretion of the
               Committee, the Grantee may pay all or a portion of the purchase
               price by tender of Common Stock or a combination of stock and
               cash or other means determined by the Committee.

        4.2    Any notice under this Section shall include an undertaking to
               furnish or execute such documents as the Committee in its
               discretion shall deem necessary (i) to evidence such exercise, in
               whole or in part, of the Option evidenced by this Agreement, (ii)
               to determine whether registration is then required under the
               Securities Act of 1933, or any other law, as then in effect, and
               (iii) to comply with or satisfy the requirements of the
               Securities Act of 1933, or any other law, as then in effect.

        4.3    The Grantee agrees that all shares purchased by him under the
               Option will be acquired for investment, not distribution, and
               that any notice of exercise of the Option must be accompanied by
               a written representation to that effect, signed by the Grantee.

                                    SECTION 5
                              TERMINATION OF OPTION

        5.1    The Option granted hereby shall terminate and be of no force or
               effect upon the expiration of ten years from the date of the
               Grant unless terminated prior to such time as provided below.

        5.2    Subject to Section 3.6, hereof if the Amended and Restated
               License Agreement is terminated by PARTEQ, the Option may be
               exercised, to the extent exercisable, for a period of three
               months after the date of such termination or such later date as
               the Company's Board of Directors may approve; and if such
               Agreement is terminated by DUSA, the Option shall continue to
               vest in the Grantee as provided in Section 3.1 above.

        5.3    Any determination made by the Committee with respect to any
               matter referred to in this Section 5 shall be final and
               conclusive on all persons affected thereby.

                                    SECTION 6
                              ADJUSTMENTS TO OPTION

        6.1    Subject to any required action by the Committee and shareholders,
               the number of shares provided for in the Option, and the price
               per share thereof shall be proportionately adjusted for any
               increase or decrease in the number of issued shares of the
               Company resulting from the payment of a share dividend, a share
               split or any transaction which is a "corporate transaction" (as
               defined in the Treasury regulations promulgated under Section 424
               of the Code.

        6.2    Subject to any required action by the Committee and shareholders,
               if the Company shall be the surviving entity in any merger or
               consolidation, or after a consolidation







                                       3
<PAGE>   4

               of the Company and one or more entities in which the resulting
               entity is an independent entity, the Option shall pertain to and
               apply to the securities of the surviving entity in an amount that
               the board of directors of the surviving entity, at its sole
               discretion, determines to be equivalent, as nearly as
               practicable, to the nearest whole number and class of shares that
               were subject to the Option. These shares of stock or other
               securities shall, after such merger or consolidation, be deemed
               to be shares for all purposes hereof. The aforesaid adjustments,
               when applicable, shall be made by the Committee, and the
               Committee's determination shall be final, binding and conclusive.

        6.3    In the event of a Change of Control (as defined below), any and
               all outstanding Options not fully vested shall automatically vest
               in full and shall be immediately exercisable. The date on which
               such accelerated vesting and immediate exercisability shall occur
               shall be the date of the occurrence of the Change of Control.

               A "Change of Control" shall be deemed to have taken place upon
               (i) the acquisition by a third person, including a "group" as
               defined in Section 13(d)(3) of the Securities Exchange Act of
               1934, as amended, of shares of the Company having 50% or more of
               the total number of votes that may be cast for the election of
               Directors of the Company; (ii) shareholder approval of a
               transaction for the acquisition of the Company, or substantially
               all of its assets by another entity or for a merger,
               reorganization, consolidation or other business combination to
               which the Company is a part; or (iii) the election during any
               period of 24 months or less of 50% or more of the Directors of
               the Company where such Directors were not in office immediately
               prior to such period provided, however, that no "Change of
               Control" shall be deemed to have taken place if the Directors of
               the Company in office on the date of adoption of the Plan, or
               their successors in office nominated by such Directors,
               affirmatively approve a resolution to such effect.

               Except as provided with respect to a Grantee in his stock option
               agreement or other controlling agreement between him and the
               Company, to the extent that the acceleration, exercisability or
               parachute payment attributable to the Option following a Change
               of Control would result in "excess parachute payments"(1) when
               the former are aggregated with other payments or benefits to the
               Grantee, such parachute payments or benefits provided to a
               Grantee under this Agreement shall be reduced to the extent
               necessary so that no portion thereof shall be subject to the
               excise tax imposed by Section 4999 of the Code. This reduction
               will only be made if it will cause the Grantee's net after-tax
               benefit to exceed the net after-tax benefit that would have
               existed if such reduction were not made. "Net after-tax benefit"
               shall be the sum of (i) all payments and benefits which a Grantee
               receives or is entitled to receive that would constitute a
               "parachute payment" under Section 280G of the Code, less (ii) the
               amount of federal income taxes payable with respect to the
               payments and

- --------------------
        (1) "Excess parachute payments" are defined in Section 280G of the Code
and are determined by tax counsel of the Company.


                                       4
<PAGE>   5

               benefits described in (i) above, calculated at the maximum
               marginal income tax rate(2) for the year in which such payments
               and benefits shall be paid to the Grantee, less (iii) the amount
               of excise taxes imposed with respect to the payments and benefits
               described in (i) above by Section 4999 of the Code.

        6.4    In the event of a change in the Company's shares which is limited
               to a change of all of its authorized shares with par value into
               the same number of shares with a different par value or without
               par value, the shares resulting from any such change shall be
               deemed to be shares within the meaning of this Agreement.

        6.5    Except as herein before expressly provided in Paragraphs 6.1,
               6.2, 6.3 and 6.4 of this Section 6, the Grantee shall have no
               rights by reason of any subdivision or consolidation of shares of
               any class or payment of any share dividend or any other increase
               or decrease in the number of shares of any class or by reason of
               any dissolution, liquidation, merger, consolidation or spin-off
               of assets or stock of another corporation and any issuance by the
               Company of shares of any class, or securities convertible into
               shares of any class, shall not affect the Option, and no
               adjustment by reason thereof shall be made with respect to the
               number or price of the Company's shares subject to the Option.
               The grant of the Option shall not affect in any way the right or
               power of the Company to make adjustments, reclassifications,
               reorganizations or changes of its capital or business structure
               or to merge, consolidate, dissolve, liquidate, sell or transfer
               all or any part of its business or assets.

                                    SECTION 7
                                    TRANSFER

        7.1    This Option shall not be transferable by the Grantee in any way.
               During the lifetime of the Grantee, the Option shall be
               exercisable only by him. Any other attempted assignment,
               transfer, pledge, hypothecation or other disposition of the
               Option shall be void and have no effect unless in accordance with
               the terms set forth herein.

                                    SECTION 8
                                WITHHOLDING TAXES

        8.1    The Company shall have the right to retain and withhold from any
               payment, under the Option granted, any amount that is to be
               withheld or otherwise deducted and paid with respect to such
               payment. At its discretion, the Company may require the Grantee,
               if it receives shares under a nonqualified stock option grant, to
               reimburse the Company for any taxes that are required to be
               withheld by the Company, and may withhold any distribution in
               whole or in part until the Company is so reimbursed. In lieu
               thereof, the Company shall have the right to withhold from any
               other cash amounts due (or to become due) to the Grantee an
               amount equal to such taxes required to be withheld by the Company
               to reimburse the Company for any such

- ---------------------
        (2) "This rate is based on the rate for the year set forth in the Code
at the time of the first payment to the participant.


                                       5
<PAGE>   6

               taxes, or the Company may retain and withhold a number of shares
               of Common Stock having a market value not less than the amount of
               such taxes and cancel (in whole or in part) any shares of Common
               Stock so withheld in order to reimburse the Company for any such
               taxes.

                                    SECTION 9
                            IMPACT ON OTHER BENEFITS

        9.1    The value of the Option (either on the date of grant of the
               Option or at the time the shares are vested) shall not be
               includable as compensation or earnings for purposes of any other
               benefit plan offered by the Company.

                                   SECTION 10
                                 ADMINISTRATION

        10.1   The Committee shall have full authority and discretion to decide
               all matters relating to the administration and interpretation of
               this Agreement. All such Committee determinations shall be final,
               conclusive and binding upon the Company, the Grantee and any and
               all interested parties.

                                   SECTION 11
                                  AMENDMENT(S)

        11.1   This Agreement may not in any way be amended without the
               Grantee's written consent.

                                   SECTION 12
                                FORCE AND EFFECT

        12.1   The various provisions of this Agreement are severable in their
               entirety. Any determination of invalidity or unenforceability of
               any one provision shall have no effect on the continuing force
               and effect of the remaining provisions.

                                   SECTION 13
                         NOTICE OF DISPOSITION OF SHARES

        13.1   The Grantee agrees that if he should dispose of any shares of
               Common Stock acquired on the exercise of the Option, including a
               disposition by sale, exchange, gift or transfer of legal title
               within twelve (12) months of the date such shares are transferred
               to the Grantee, the Grantee will notify the Company promptly of
               such disposition.



                                       6
<PAGE>   7


                                   SECTION 14
                                    NOTICES

        14.1   All notices which may be or are required to be given by one party
               to the other party pursuant to this Agreement shall be in writing
               and shall be mailed by first class or certified mail, return
               receipt requested, postage prepaid, or transmitted by hand
               delivery as follows:

               If to the Company:   DUSA Pharmaceuticals, Inc.
                                    181 University Avenue
                                    Suite 1208
                                    Toronto, ON M5H 3M7
                                    CANADA

                                    Attention:  Dr. D. Geoffrey Shulman

               If to the Grantee:   Dean Van Vugt

               or such other address as to which either party may from time to
               time notify the other as aforesaid.

                                   SECTION 15
                            RESTRICTIONS ON TRANSFER

        15.1   The Grantee understands and acknowledges that he is subject to
               certain restrictions on transfer under the Securities Act of 1933
               of the United States, as amended, (the "1933 Act") of the shares
               issued pursuant to the exercise of the Option; such restrictions
               provide that the shares may not be sold without registration or
               exemption from registration under the 1933 Act.

                                   SECTION 16
                             REPORTING REQUIREMENTS

        16.1   The Grantee understands and acknowledges that he may be subject
               to certain reporting requirements upon his receipt and exercise
               of the Option, and in connection therewith, upon the receipt and
               exercise of the Option, the Grantee agrees to timely file with
               the Securities and Exchange Commission, the National Association
               of Securities Dealers, Inc., and any appropriate Canadian
               securities regulatory authorities, the appropriate documentation
               regarding his ownership of the Company's securities.


                                       7
<PAGE>   8


                                   SECTION 17
                                  GOVERNING LAW

        17.1   This Agreement shall be construed and enforced in accordance with
               and governed by the laws of the State of New Jersey.

        IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
hereto.

Attest:                                   DUSA PHARMACEUTICALS, INC.,
                                          a New Jersey corporation


s/ Nanette W. Mantell                     By: s/ D. Geoffrey Shulman
- ----------------------------------           ---------------------------------
Nanette W. Mantell, Secretary                 Dr. D. Geoffrey Shulman, President


                                          GRANTEE


                                              s/Dean Van Vugt
                                             ---------------------------------
                                              Dean Van Vugt




                                       8
<PAGE>   9



                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:     The Secretary of DUSA Pharmaceuticals, Inc.

        Pursuant to the terms and subject to the conditions set forth in the
Nonqualified Stock Option Agreement (the "Agreement") dated October 21, 1997,
between DUSA Pharmaceuticals, Inc. and the undersigned, and the Option granted
to the undersigned by such Agreement, I hereby elect to purchase _________
shares of Common Stock of DUSA Pharmaceuticals, Inc. which were the subject of
such Option. I understand that such purchase is subject to all the terms and
conditions of the Agreement. I request that the certificates for such shares of
Common Stock shall be issued in the name of:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

        The undersigned hereby represents and warrants to, and agrees with the
Company as follows:

        (a) The shares are being purchased for the undersigned's own account,
for investment purposes only, and not for the account of any other person, and
not with a view to distribution, assignment, or resale to others, or to
fractionalization in whole or in part and that the offering and sale of the
shares is intended to be exempt from registration under the Securities Act of
1933 (the "Act"). In furtherance thereof, the undersigned represents, warrants
and agrees as follows: (i) no other person has or will have a direct or indirect
beneficial interest in such shares and the undersigned will not sell,
hypothecate, or otherwise transfer his shares except in accordance with the Act
and applicable state securities laws or unless in the opinion of counsel for the
Company, an exemption from the registration requirements of the Act and such
laws is available; and (ii) the Company is under no obligation to register the
shares on behalf of the undersigned or to assist the undersigned in complying
with any exemption from registration.


<PAGE>   10

        (b) The undersigned has such knowledge and experience in financial and
business matters that the undersigned is capable of evaluating the merits and
risks of investment in the Company and of making an informed investment
decision.

        In full payment of the purchase price with respect to the Option
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian or
United States currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                              X
                                     -----------------------------------------
                                                  (Signature)

                                           -----------------------------------
                                                  Name (Please Print)

                                           -------------------------------------
                                                  (Address)

                                           -------------------------------------
                                                  Taxpayer Identification Number


<PAGE>   1
                                                                    Exhibit 4.13

                             STOCK OPTION AGREEMENT

        THIS AGREEMENT is made as of the 15th day of July, 1992 between DEPRENYL
USA, INC., a corporation incorporated under the laws of the State of New Jersey
(hereinafter referred to as the "Company") and MARTIN BARKIN, MD, BSc (MED), MA,
FRCSC, an individual residing at 54 Old Forest Hill Road, Toronto, Ontario M5P
2P9, CANADA (hereinafter referred to as the "Participant").

        WITNESSETH:

        WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant an option to him to
purchase shares of the Company's common stock ("Shares") on the terms and
conditions set forth in this Agreement.

        NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:

1.1     DEFINITIONS

        In this Agreement:

        "Board of Directors" means the board of directors of the Company;

        "Exercise Price" means CDN. $12.875;

        "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later
        of the dates provided in Section 2.2;

        "Optioned Shares" means that number of Shares which are subject to the
        option granted by the Company to the Participant pursuant to this
        Agreement; and

        "Shares" means shares of common stock, without par value, of the
        Company.

2.1     GRANT OF OPTION

        The Company hereby grants to the Participant an option to purchase, in
        accordance with the vesting rights outlined in Sections 2.6 and 2.7
        hereof, up to 20,000 Shares for an amount per Share equal to the
        Exercise Price, upon the terms and subject to the conditions herein
        contained.

2.2     Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have
        the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on the
        fifth anniversary date hereof, being July



<PAGE>   2

        15, 1997 (provided that if such day is not a day on which the Company is
        open for business then on the first following day on which the Company
        is open for business) to exercise this option for any number of the
        Optioned Shares up to the maximum number of Shares specified in Section
        2.1 above.

2.3     The option may be exercised by the Participant or by his executors or
        personal representatives in the circumstances described in Section 4.1
        by providing to the Company notice in writing in the form of Schedule A
        hereto setting out the number of Optioned Shares with respect to which
        the option is being exercised. The notice must be accompanied by a
        certified check, official bank cashier's check or money order in an
        amount equal to the Exercise Price multiplied by the number of Shares
        requested and a duly executed copy of this Agreement.

2.4     The Company shall cause its registrar and transfer agent to deliver to
        the Participant as soon as practicable after receipt of such notice and
        payment a certificate or certificates registered in the name of the
        Participant or as the Participant may direct for the number of Shares
        with respect to which the option is duly exercised.

2.5     Nothing contained in this Agreement or action taken pursuant hereto
        shall obligate the Participant to purchase and/or pay for, or the
        Company to issue, any Shares except those Optioned Shares with respect
        to which the Participant shall have duly exercised the option to
        purchase in accordance with this Agreement.

2.6     Subject to Section 2.7 hereof, the option granted hereunder shall vest
        in the following manner:

        (a)    one-quarter of the option on the first anniversary of the day
               immediately preceding the date hereof, being July 14, 1993;

        (b)    one-quarter of the option on the second anniversary of the day
               immediately preceding the date hereof, being July 14, 1994;

        (c)    one-quarter of the option on the third anniversary of the day
               immediately preceding the date hereof, being July 14, 1995; and

        (d)    one-quarter of the option on the fourth anniversary of the day
               immediately preceding the date hereof, being July 14, 1996;

        and, except as provided by Section 6.1, the Participant shall only be
        entitled to exercise this option in the amounts set out above and from
        and after the dates so specified.

2.7     Notwithstanding anything contained in Section 2.6 hereof, the option
        shall continue to vest only so long as the Participant continues to
        serve the Company as a director. Should the Participant cease to serve
        in such capacity ("Termination"), no further vesting of the option shall
        occur and the provisions of Section 3.1 shall apply with respect to the
        exercise of the option to the extent that it has vested and has not yet
        been exercised.



                                       2
<PAGE>   3


3.1     EXPIRATION ON TERMINATION

        Subject to Section 4.1 hereof, upon Termination, such part of the option
        as is then vested but unexercised may be exercised by the Participant
        for a period of ninety (90) days after Termination or such later date as
        the Board of Directors may approve after which time this option shall
        expire; provided, however, that in no event may this option be exercised
        after the Expiration Date.

4.1     DEATH OR PERMANENT DISABILITY

        In the event that on or prior to the Expiration Date, the Participant
        dies or becomes totally and permanently disabled while serving the
        Company as a director, this option, to the extent then vested but
        unexercised, may be exercised by the Participant for a period of up to
        six (6) months after the death or disability of the Participant;
        provided, however, that in no event may this option be exercised after
        the Expiration Date. Disability shall be defined as in Section 22(e)(3)
        of the Internal Revenue Code of 1986, as amended. For the purposes of
        this provision only, reference to the Participant in this Agreement
        shall be construed as including the executors or personal
        representatives of a deceased Participant. In the event that this option
        is not exercised within the period of six (6) months set out above, this
        option shall expire.

5.1     SUBDIVISION, CONSOLIDATION OR REORGANIZATION

        (a) In the event of any subdivision, redivision or change of the Shares
        of the Company into a greater number of Shares at any time after the
        date of this Agreement and prior to the Expiration Date of this option,
        the Company shall deliver at the time of exercise of this option, but
        for the same aggregate consideration payable therefor, such additional
        number of Shares as the Participant would have been entitled to receive
        as a result of such subdivision, redivision or change if on the record
        date thereof the Participant had been the registered holder of the
        number of such Shares with respect to which the option is later
        exercised.

        (b) In the event of any consolidation or change of the Shares of the
        Company into a lesser number of Shares at any time after the date of
        this Agreement and prior to the expiration of this option, the Company
        shall deliver at the time of exercise of this option, but for the same
        aggregate consideration payable therefor, such reduced number of Shares,
        as the Participant would have been entitled to receive upon such
        consolidation or change if on the record date thereof the Participant
        had been the registered holder of the number of such Shares with respect
        to which the option is later exercised.

        (c) If at any time after the date of this Agreement and prior to the
        expiration of this option, the Shares shall be reclassified or
        reorganized, otherwise than as specified in Sections 5.1(a) and (b), the
        Participant shall be entitled to receive upon the exercise of this
        option and shall accept in lieu of the number of Shares then subscribed
        for, but for the same aggregate consideration payable therefor, the same
        aggregate number of shares of the appropriate class of shares that the
        Participant would have been entitled to receive as a result of such
        reclassification or other reorganization of Shares if on the record date
        thereof the Participant

                                       3
<PAGE>   4

        had been the registered holder of the number of such Shares with respect
        to which the option is later exercised.

6.1     TAKE-OVER BID

        If an offeror makes an offer to purchase 50% or more of the outstanding
        Shares to substantially all holders of the Shares or, if an insider of
        the Company makes an offer to purchase Shares to substantially all
        holders of the Shares, and the Board of Directors recommends acceptance
        of such offer to the shareholders of the Company and the offer price is
        greater than the Exercise Price, then this option, whether or not it has
        vested in whole or in part, shall become immediately exercisable. The
        Participant shall be bound to exercise this option and to tender the
        Optioned Shares issued upon exercise of this option into the offer upon
        receipt of notice from the Company if the Company provides an
        interest-free loan to the Participant in the amount of the Exercise
        Price for all of the Optioned Shares issuable upon exercise of this
        option, subject to the execution of a security agreement by the
        Participant in favor of the Company securing repayment of the loan.

7.1     NO ASSIGNMENT

        The Participant may not assign, transfer, pledge or hypothecate any of
        his rights hereunder in any way (whether by operation of law or
        otherwise) except by will or by the laws of succession on intestacy
        which may apply to the estate of the Participant upon his death. The
        option granted herein shall not be subject to execution, attachment or
        similar process. Upon any attempt to assign, transfer, pledge,
        hypothecate or otherwise dispose of this option contrary to the
        provisions hereof, or upon the levy of any attachment or similar process
        upon the option granted herein, such option shall immediately become
        void.

8.1     GENERAL

        (a) Time shall be of the essence of this Agreement.

        (b) In this Agreement, words importing the singular number include the
        plural and vice versa and words importing the masculine gender include
        the feminine and neuter genders.

        (c) All notices which may be or are required to be given by one party to
        the other party pursuant to this Agreement shall be in writing and shall
        be mailed by first class or certified mail, return receipt requested,
        postage prepaid, or transmitted by hand delivery as follows:



                                       4
<PAGE>   5


<TABLE>
<S>                                     <C>
        If to the Company:                  Deprenyl USA, Inc.
                                            378 Roncesvalles Ave.
                                            Toronto, ON M6R 2M7
                                            CANADA

                                            Attention:  Dr. D. Geoffrey Shulman

               with a copy to:              Nanette W. Mantell, Esq., Corporate Secretary
                                            Lane and Mantell
                                            991 Route 22 West
                                            PO Box 8539
                                            Somerville, NJ 08876
                                            U.S.A.

        If to the Participant:              at the address of the Participant
                                            from time to time in the records of the Company,
</TABLE>

        or such other address as to which either party may from time to time
        notify the other as aforesaid.

9.1     RESTRICTIONS ON TRANSFER

        The Participant understands and acknowledges that the option and Shares
        underlying the option have not been registered and that they are subject
        to certain restrictions on transfer under the Securities Act of 1933 of
        the United States, as amended, (the "1933 Act"); such restrictions
        provide that the Shares may not be sold without registration or
        exemption from registration under the 1933 Act; and, for purposes of the
        Securities Act (Ontario) (the "Ontario Act"), the first trade of the
        Shares issued pursuant to the exercise of the option, other than a trade
        exempted by the Ontario Act, will be a distribution unless the Company
        has been a reporting issuer for at least twelve (12) months and the
        Company is not in default of any requirement of the Ontario Act,
        disclosure has been made to the Ontario Securities Commission of the
        exempt trade, no unusual effort is made to prepare the market or create
        a demand for the Shares, and no extraordinary commission or
        consideration is paid with respect to the trade, provided that such
        first trade is not from the holdings of a so-called "control block".

10.1    REPORTING REQUIREMENTS

        The Participant understands and acknowledges that he will be subject to
        certain reporting requirements upon his receipt and exercise of the
        option, and in connection therewith, upon the receipt and exercise of
        the option, the Participant agrees to timely file with the Securities
        and Exchange Commission, the National Association of Securities Dealers,
        Inc., and any appropriate Canadian securities regulatory authorities,
        the appropriate documentation regarding his ownership of the Company's
        securities.



                                       5
<PAGE>   6


        IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
hereto.

        IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
hereto.

Attest:                               DEPRENYL USA, INC.
                                      a New Jersey corporation


s/Edward L. Foster                    By: s/D. Geoffrey Shulman
- ---------------------------------         -----------------------------
Edward L. Foster, Treasurer               Dr. D. Geoffrey Shulman, President


                                      PARTICIPANT


                                      s/Martin Barkin
                                      ---------------------------------
                                      Martin Barkin, MD, BSc (MED),
                                      MA, FRCSC



                                       6
<PAGE>   7



                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:     The Secretary of Deprenyl USA, Inc.

        Pursuant to the terms and subject to the conditions set forth in the
Stock Option Agreement (the "Agreement") dated    , between Deprenyl USA, Inc.
and the undersigned, I hereby elect to purchase      shares of Common Stock of
Deprenyl USA, Inc. I understand that such purchase is subject to all the terms
and conditions of the Agreement. I request that the certificates for such shares
of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

        In full payment of the purchase price with respect to the Optioned
Shares exercised, the undersigned hereby tenders payment of $___________ by
certified check or official bank cashier's check or money order payable in
Canadian currency to the order of Deprenyl USA, Inc.

Dated:                         X
                                ---------------------------------------
                                      (Signature)

                                      -------------------------------------
                                      Name (Please Print)

                                      -------------------------------------
                                      (Address)

                                      -------------------------------------
                                      Taxpayer Identification Number



<PAGE>   1
                                                                 Exhibit 4.14(a)

                             STOCK OPTION AGREEMENT

        THIS AGREEMENT is made as of the 14 day of April, 1994 between DUSA
PHARMACEUTICALS, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and RONALD L. CARROLL, who
resides at 166 Otis Street, Hingham, Massachusetts 02043 (hereinafter referred
to as the "Participant").

                                   WITNESSETH:

        WHEREAS, the Company granted on April 14, 1994 (the "Grant Date") to
Lumenetics, Inc., a corporation incorporated under the laws of the State of
Delaware, ("Lumenetics") stock options for 20,000 shares of the Company's common
stock (the "Options"); and

        WHEREAS, Lumenetics has determined to assign its interest in the Options
to Ronald L. Carroll and Scott Lundahl, the principal shareholders of
Lumenetics; and

        WHEREAS, the Company has determined that it is in the Company's interest
to acknowledge the assignment by Lumenetics of the Options to purchase shares of
the Company's common stock ("Shares") on the terms and conditions set forth in
this Agreement.

        NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:

1.1     DEFINITIONS

        In this Agreement:

        "Board of Directors" means the board of directors of the Company;

        "Exercise Price" means U.S. $3.625;

        "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later
        of the dates provided in Section 2.2;

        "Optioned Shares" means that number of Shares which are subject to the
        option granted by the Company to the Participant pursuant to this
        Agreement;

        "Services" means consulting or other services provided by the
        Participant to the Company; and

        "Shares" means shares of common stock, without par value, of the
        Company.


<PAGE>   2


2.1     GRANT OF OPTION

        The Company hereby grants to the Participant an option to purchase, in
        accordance with the vesting rights outlined in Sections 2.6 and 2.7
        hereof, up to 10,000 SHARES for an amount per Share equal to the
        Exercise Price, upon the terms and subject to the conditions herein
        contained.

2.2     Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have
        the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on the
        tenth (10th) anniversary date hereof, being April 14, 2004 (provided
        that if such day is not a day on which the Company is open for business
        then on the first following day on which the Company is open for
        business) to exercise this option for any number of the Optioned Shares
        up to the maximum number of Shares specified in Section 2.1 above.

2.3     The option may be exercised by the Participant or by his executors or
        personal representatives in the circumstances described in Section 4.1
        by providing to the Company notice in writing in the form of Schedule A
        hereto setting out the number of Optioned Shares with respect to which
        the option is being exercised. The notice must be accompanied by a
        certified check, official bank cashier's check or money order in an
        amount equal to the Exercise Price multiplied by the number of Shares
        requested and a duly executed copy of this Agreement.

2.4     The Company shall cause its registrar and transfer agent to deliver to
        the Participant as soon as practicable after receipt of such notice and
        payment a certificate or certificates registered in the name of the
        Participant or as the Participant may direct for the number of Shares
        with respect to which the option is duly exercised.

2.5     Nothing contained in this Agreement or action taken pursuant hereto
        shall obligate the Participant to purchase and/or pay for, or the
        Company to issue, any Shares except those Optioned Shares with respect
        to which the Participant shall have duly exercised the option to
        purchase in accordance with this Agreement.

2.6     Subject to Section 2.7 hereof, the option granted hereunder shall vest
        in the following manner:

        (a)    one-quarter of the option on the first anniversary of the day
               immediately preceding the date hereof, being April 13, 1995;

        (b)    one-quarter of the option on the second anniversary of the day
               immediately preceding the date hereof, being April 13, 1996;

        (c)    one-quarter of the option on the third anniversary of the day
               immediately preceding the date hereof, being April 13, 1997; and

        (d)    one-quarter of the option on the fourth anniversary of the day
               immediately preceding the date hereof, being April 13, 1998;



                                       2
<PAGE>   3


        and, except as provided by Section 6.1, the Participant shall only be
        entitled to exercise this option in the amounts set out above and from
        and after the dates so specified.

2.7     Notwithstanding anything contained in Section 2.6 hereof, the option
        shall continue to vest only so long as the Participant continues to
        provide Services to the Company. Should the Participant cease to provide
        such Services ("Termination"), no further vesting of the option shall
        occur unless the Board of Directors determines otherwise and the
        provisions of Section 3.1 shall apply with respect to the exercise of
        the option to the extent that it has vested and has not yet been
        exercised.

3.1     EXPIRATION ON TERMINATION

        Subject to Section 4.1 hereof, upon Termination, such part of the option
        as is then vested but unexercised may be exercised by the Participant
        for a period of ninety (90) days after Termination or such later date as
        the Board of Directors may approve after which time this option shall
        expire; provided, however, that in no event may this option be exercised
        after the Expiration Date.

4.1     DEATH OR PERMANENT DISABILITY

        In the event that on or prior to the Expiration Date, the Participant
        dies or becomes totally and permanently disabled while providing
        Services to the Company, this option, to the extent then vested but
        unexercised, may be exercised by the Participant for a period up to six
        (6) months after the death or disability of the Participant; provided,
        however, that in no event may this option be exercised after the
        Expiration Date. Disability shall be defined as in Section 22(e)(3) of
        the Internal Revenue Code of 1986, as amended. For the purposes of this
        provision only, reference to the Participant in this Agreement shall be
        construed as including the executors or personal representatives of a
        deceased Participant. In the event that this option is not exercised
        within the period of six (6) months set out above, this option shall
        expire.

5.1     SUBDIVISION, CONSOLIDATION OR REORGANIZATION

        (a) In the event of any subdivision, redivision or change of the Shares
        of the Company into a greater number of Shares at any time after the
        date of this Agreement and prior to the Expiration Date of this option,
        the Company shall deliver at the time of exercise of this option, but
        for the same aggregate consideration payable therefor, such additional
        number of Shares as the Participant would have been entitled to receive
        as a result of such subdivision, redivision or change if on the record
        date thereof the Participant had been the registered holder of the
        number of such Shares with respect to which the option is later
        exercised.

        (b) In the event of any consolidation or change of the Shares of the
        Company into a lesser number of Shares at any time after the date of
        this Agreement and prior to the expiration of this option, the Company
        shall deliver at the time of exercise of this option, but for the same
        aggregate consideration payable therefor, such reduced number of Shares,
        as the Participant would have been entitled to receive upon such
        consolidation or change if on



                                       3
<PAGE>   4

        the record date thereof the Participant had been the registered holder
        of the number of such Shares with respect to which the option is later
        exercised.

        (c) If at any time after the date of this Agreement and prior to the
        expiration of this option, the Shares shall be reclassified or
        reorganized, otherwise than as specified in Sections 5.1(a) and (b), the
        Participant shall be entitled to receive upon the exercise of this
        option and shall accept in lieu of the number of Shares then subscribed
        for, but for the same aggregate consideration payable therefor, the same
        aggregate number of shares of the appropriate class of shares that the
        Participant would have been entitled to receive as a result of such
        reclassification or other reorganization of Shares if on the record date
        thereof the Participant had been the registered holder of the number of
        such Shares with respect to which the option is later exercised.

6.1     TAKE-OVER BID

        If an offeror makes an offer to purchase 50% or more of the outstanding
        Shares to substantially all holders of the Shares or, if an insider of
        the Company makes an offer to purchase Shares to substantially all
        holders of the Shares, and the Board of Directors recommends acceptance
        of such offer to the shareholders of the Company and the offer price is
        greater than the Exercise Price, then this option, whether or not it has
        vested in whole or in part, shall become immediately exercisable. The
        Participant shall be bound to exercise this option and to tender the
        Optioned Shares issued upon exercise of this option into the offer upon
        receipt of notice from the Company if the Company provides an
        interest-free loan to the Participant in the amount of the Exercise
        Price for all of the Optioned Shares issuable upon exercise of this
        option, subject to the execution of a security agreement by the
        Participant in favor of the Company securing repayment of the loan.

7.1     NO ASSIGNMENT

        The Participant may not assign, transfer, pledge or hypothecate any of
        his rights hereunder in any way (whether by operation of law or
        otherwise) except by will or by the laws of succession on intestacy
        which may apply to the estate of the Participant upon his death. The
        option granted herein shall not be subject to execution, attachment or
        similar process. Upon any attempt to assign, transfer, pledge,
        hypothecate or otherwise dispose of this option contrary to the
        provisions hereof, or upon the levy of any attachment or similar process
        upon the option granted herein, such option shall immediately become
        void.

8.1     GENERAL

        (a) Time shall be of the essence of this Agreement.

        (b) In this Agreement, words importing the singular number include the
        plural and vice versa and words importing the masculine gender include
        the feminine and neuter genders.

        (c) All notices which may be or are required to be given by one party to
        the other party pursuant to this Agreement shall be in writing and shall
        be mailed by first class or certified mail, return receipt requested,
        postage prepaid, or transmitted by hand delivery as follows:



                                       4
<PAGE>   5




                                       5
<PAGE>   6

<TABLE>
     <S>                                <C>
        If to the Company:                  DUSA Pharmaceuticals, Inc.
                                            181 University Avenue, Suite 1208
                                            Toronto, ON M5H 3M7
                                            CANADA

                                            Attention:  Dr. D. Geoffrey Shulman

               with a copy to:              Nanette W. Mantell, Esq., Corporate Secretary
                                            Lane and Mantell
                                            991 Route 22 West
                                            PO Box 8539
                                            Somerville, NJ 08876
                                            U.S.A.

        If to the Participant:              at the address of the Participant from time to time in
                                            the records of the Company,
</TABLE>

        or such other address as to which either party may from time to time
        notify the other as aforesaid.

9.1     RESTRICTIONS ON TRANSFER

        The Participant understands and acknowledges that the option and Shares
        underlying the option have not been registered and that they are subject
        to certain restrictions on transfer under the Securities Act of 1933 of
        the United States, as amended, (the "1933 Act"); such restrictions
        provide that the Shares may not be sold without registration or
        exemption from registration under the 1933 Act; and, for purposes of the
        Securities Act (Ontario) (the "Ontario Act"), the first trade of the
        Shares issued pursuant to the exercise of the option, other than a trade
        exempted by the Ontario Act, will be a distribution unless the Company
        has been a reporting issuer for at least twelve (12) months and the
        Company is not in default of any requirement of the Ontario Act,
        disclosure has been made to the Ontario Securities Commission of the
        exempt trade, no unusual effort is made to prepare the market or create
        a demand for the Shares, and no extraordinary commission or
        consideration is paid with respect to the trade, provided that such
        first trade is not from the holdings of a so-called "control block".



                                       6
<PAGE>   7


        IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
hereto.

Attest:                                 DUSA PHARMACEUTICALS, INC.

                                        a New Jersey corporation


s/Nanette W. Mantell                    By:  s/D. Geoffrey Shulman
- ------------------------------------        --------------------------------
Nanette W. Mantell, Secretary               Dr. D. Geoffrey Shulman, President


                                        PARTICIPANT


                                        s/ Ronald L. Carroll
                                        ------------------------------------
                                        Ronald L. Carroll



                                       7
<PAGE>   8



                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:     The Secretary of DUSA Pharmaceuticals, Inc.

        Pursuant to the terms and subject to the conditions set forth in the
Stock Option Agreement (the "Agreement") dated         , between DUSA
Pharmaceuticals, Inc. and the undersigned, I hereby elect to purchase     shares
of Common Stock of DUSA Pharmaceuticals, Inc. I understand that such purchase is
subject to all the terms and conditions of the Agreement. I request that the
certificates for such shares of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

        In full payment of the purchase price with respect to the Optioned
Shares exercised, the undersigned hereby tenders payment of $___________ by
certified check or official bank cashier's check or money order payable in
Canadian currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                          X
                                 -------------------------------------------
                                       (Signature)

                                       -------------------------------------
                                       Name (Please Print)

                                       -------------------------------------
                                       (Address)

                                       -------------------------------------
                                       Taxpayer Identification Number

<PAGE>   9
                                                                 Exhibit 4.14(b)

                       NONQUALIFIED STOCK OPTION AGREEMENT

        AGREEMENT made and entered into as of the 13TH day of MARCH, 1997, by
and between DUSA Pharmaceuticals, Inc., a corporation incorporated under the
laws of the State of New Jersey (the "Company"), and RONALD L. CARROLL, who
resides at 166 Otis Street, Hingham, Massachusetts 02043 (the "Grantee").

        WHEREAS, the Company granted on March 13, 1997 (the "Grant Date") to
Lumenetics, Inc., a corporation incorporated under the laws of the State of
Delaware, ("Lumenetics") stock options for 100,000 shares of the Company's
common stock (the "Options"); and

        WHEREAS, Lumenetics has determined to assign its interest in the Options
to Ronald L. Carroll and Scott Lundahl, the principal shareholders of
Lumenetics; and

        WHEREAS, the Company has determined that its interests will be advanced
by acknowledging the assignment by Lumenetics of the Options.

        NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, the parties hereby agree as follows:

                                    SECTION 1
                                      GRANT

        1.1    The Company hereby acknowledges the assignment to the Grantee of
               the right and option (the "Option") to purchase, in accordance
               with the vesting rights outlined in Sections 3.1 and 3.6 hereof,
               up to 50,000 shares of authorized but unissued Common Stock,
               without par value ("Common Stock"), of the Company on the terms
               and conditions herein set forth in this Agreement.

                                    SECTION 2
                                      PRICE

        2.1    The purchase price of the shares of Common Stock subject to this
               Option shall be the fair market value of the shares of Common
               Stock on the Grant Date ($6.125 per share)(the "Exercise Price").

                                    SECTION 3
                                WHEN EXERCISABLE

        3.1    The aggregate number of shares of Common Stock of the Company
               optioned by this Agreement (the "Optioned Shares") shall vest in
               the Grantee as follows:

               (a)    25% of the Option on the day of the grant, being March 13,
               1997;


<PAGE>   10


               (b)    25% of the Option on the second anniversary of the day of
                      grant, being March 13, 1999;

               (c)    25% of the Option on the third anniversary of the day of
                      the grant, being March 13, 2000;

               (d)    25% of the Option on the fourth anniversary of the day of
                      the grant, being March 13, 2001; and

        and, except as provided by Sections 3.6 and 6.3 hereof, the Grantee
        shall only be entitled to exercise this Option, in whole or in part, in
        the amounts set out above and from and after the dates so specified.

        3.2    Subject to Sections 3.1 and 3.6 hereof, the Grantee shall have
               the right, at any time prior to 5:00 p.m. (Eastern Standard Time)
               on the date prior to the tenth anniversary date of the grant,
               being March 12, 2007, provided that if such day is not a day on
               which the Company is open for business then on the first
               following day on which the Company is open for business, to
               exercise this Option for any number of the Optioned Shares up to
               the maximum number of shares specified in Section 1.1 above.

        3.3    No less than one thousand (1,000) shares may be purchased upon
               any one exercise of the Option granted hereby unless the number
               of shares purchased at such time is the total number of shares in
               respect of which the Option hereby granted is then exercisable.

        3.4    In no event shall any Option granted hereby be exercisable for a
               fractional share.

        3.5    From time to time, in its discretion, the Company's Stock Option
               Committee (the "Committee") may offer the Grantee the right to
               cancel any Option granted hereunder in exchange for such
               consideration as the Committee shall determine.

        3.6    Notwithstanding anything contained in Sections 1 and 3.1 hereof,
               the Option shall continue to vest in the Grantee as provided by
               the terms of Paragraph 3(d)(ii) of the Consulting and Development
               Agreement, dated October 14, 1997 (the "Consulting Agreement")
               between the Company and Lumenetics, which Consulting Agreement
               was subsequently partially terminated pursuant to a certain
               Partial Termination Agreement dated as of the February 25, 1999.
               The Board of Directors shall be entitled to determine if and when
               service to the Company has ceased with respect to the Grantee.

                                    SECTION 4
                                 HOW EXERCISABLE

        4.1    Subject to such administrative regulations as the Committee may
               from time to time adopt, the Grantee or beneficiary shall, in
               order to exercise this Option give to the Company at its
               principal office notice in writing in the form of Schedule A
               hereto setting out the number of Optioned Shares with respect to





                                       2
<PAGE>   11

               which the Option is being exercised. The notice must be
               accompanied by payment of a certified check, official bank
               cashier's check or money order in an amount equal to the Exercise
               Price multiplied by the number of shares requested and a duly
               executed copy of this Agreement. At the discretion of the
               Committee, the Grantee may pay all or a portion of the purchase
               price by tender of Common Stock or a combination of stock and
               cash or other means determined by the Committee.

        4.2    Any notice under this Section shall include an undertaking to
               furnish or execute such documents as the Committee in its
               discretion shall deem necessary (i) to evidence such exercise, in
               whole or in part, of the Option evidenced by this Agreement, (ii)
               to determine whether registration is then required under the
               Securities Act of 1933, or any other law, as then in effect, and
               (iii) to comply with or satisfy the requirements of the
               Securities Act of 1933, or any other law, as then in effect.

        4.3    The Grantee agrees that all shares purchased by it under the
               Option will be acquired for investment, not distribution, and
               that any notice of exercise of the Option must be accompanied by
               a written representation to that effect, signed by the Grantee.

                                    SECTION 5
                              TERMINATION OF OPTION

        5.1    The Option granted hereby shall terminate and be of no force or
               effect upon the expiration of ten years from the date of the
               Grant unless terminated prior to such time as provided below.

        5.2    Any determination made by the Committee with respect to any
               matter referred to in this Section 5 shall be final and
               conclusive on all persons affected thereby. Service to the
               Company shall be deemed to include service to any subsidiary of
               the Company by the Grantee.

                                    SECTION 6
                              ADJUSTMENTS TO OPTION

        6.1    Subject to any required action by the Committee and shareholders,
               the number of shares provided for in the Option, and the price
               per share thereof shall be proportionately adjusted for any
               increase or decrease in the number of issued shares of the
               Company resulting from the payment of a share dividend, a share
               split or any transaction which is a "corporate transaction" (as
               defined in the Treasury regulations promulgated under Section 424
               of the Code.

        6.2    Subject to any required action by the Committee and shareholders,
               if the Company shall be the surviving entity in any merger or
               consolidation, or after a consolidation of the Company and one or
               more entities in which the resulting entity is an independent
               entity, the Option shall pertain to and apply to the



                                       3
<PAGE>   12

               securities of the surviving entity in an amount that the board of
               directors of the surviving entity, at its sole discretion,
               determines to be equivalent, as nearly as practicable, to the
               nearest whole number and class of shares that were subject to the
               Option. These shares of stock or other securities shall, after
               such merger or consolidation, be deemed to be shares for all
               purposes hereof. The aforesaid adjustments, when applicable,
               shall be made by the Committee, and the Committee's determination
               shall be final, binding and conclusive.

        6.3    In the event of a Change of Control (as defined below), any and
               all outstanding Options not fully vested shall automatically vest
               in full and shall be immediately exercisable. The date on which
               such accelerated vesting and immediate exercisability shall occur
               shall be the date of the occurrence of the Change of Control.

               A "Change of Control" shall be deemed to have taken place upon
               (i) the acquisition by a third person, including a "group" as
               defined in Section 13(d)(3) of the Securities Exchange Act of
               1934, as amended, of shares of the Company having 50% or more of
               the total number of votes that may be cast for the election of
               Directors of the Company; (ii) shareholder approval of a
               transaction for the acquisition of the Company, or substantially
               all of its assets by another entity or for a merger,
               reorganization, consolidation or other business combination to
               which the Company is a part; or (iii) the election during any
               period of 24 months or less of 50% or more of the Directors of
               the Company where such Directors were not in office immediately
               prior to such period provided, however, that no "Change of
               Control" shall be deemed to have taken place if the Directors of
               the Company in office on the date of adoption of the Plan, or
               their successors in office nominated by such Directors,
               affirmatively approve a resolution to such effect.

               Except as provided with respect to a Grantee in its stock option
               agreement or other controlling agreement between it and the
               Company, to the extent that the acceleration, exercisability or
               parachute payment attributable to the Option following a Change
               of Control would result in "excess parachute payments"(1) when
               the former are aggregated with other payments or benefits to the
               Grantee, such parachute payments or benefits provided to a
               Grantee under this Agreement shall be reduced to the extent
               necessary so that no portion thereof shall be subject to the
               excise tax imposed by Section 4999 of the Code. This reduction
               will only be made if it will cause the Grantee's net after-tax
               benefit to exceed the net after-tax benefit that would have
               existed if such reduction were not made. "Net after-tax benefit"
               shall be the sum of (i) all payments and benefits which a Grantee
               receives or is entitled to receive that would constitute a
               "parachute payment" under Section 280G of the Code, less (ii) the
               amount of federal income taxes payable with respect to the
               payments and benefits described in (i) above,

- -------------------
        (1) "Excess parachute payments" are defined in Section 280G of the Code
and are determined by tax counsel of the Company.


                                       4
<PAGE>   13

               calculated at the maximum marginal income tax rate(2) for the
               year in which such payments and benefits shall be paid to the
               Grantee, less (iii) the amount of excise taxes imposed with
               respect to the payments and benefits described in (i) above by
               Section 4999 of the Code.

        6.4    In the event of a change in the Company's shares which is limited
               to a change of all of its authorized shares with par value into
               the same number of shares with a different par value or without
               par value, the shares resulting from any such change shall be
               deemed to be shares within the meaning of this Agreement.

        6.5    Except as herein before expressly provided in Paragraphs 6.1,
               6.2, 6.3 and 6.4 of this Section 6, the Grantee shall have no
               rights by reason of any subdivision or consolidation of shares of
               any class or payment of any share dividend or any other increase
               or decrease in the number of shares of any class or by reason of
               any dissolution, liquidation, merger, consolidation or spin-off
               of assets or stock of another corporation and any issuance by the
               Company of shares of any class, or securities convertible into
               shares of any class, shall not affect the Option, and no
               adjustment by reason thereof shall be made with respect to the
               number or price of the Company's shares subject to the Option.
               The grant of the Option shall not affect in any way the right or
               power of the Company to make adjustments, reclassifications,
               reorganizations or changes of its capital or business structure
               or to merge, consolidate, dissolve, liquidate, sell or transfer
               all or any part of its business or assets.

                                    SECTION 7
                                    TRANSFER

        7.1    This Option shall not be transferable by the Grantee in any way.
               During the existence of the Grantee, the Option shall be
               exercisable only by it. Any other attempted assignment, transfer,
               pledge, hypothecation or other disposition of the Option shall be
               void and have no effect unless in accordance with the terms set
               forth herein.

                                    SECTION 8
                                WITHHOLDING TAXES

        8.1    The Company shall have the right to retain and withhold from any
               payment, under the Option granted, any amount that is to be
               withheld or otherwise deducted and paid with respect to such
               payment. At its discretion, the Company may require the Grantee,
               if it receives shares under a nonqualified stock option grant, to
               reimburse the Company for any taxes that are required to be
               withheld by the Company, and may withhold any distribution in
               whole or in part until the Company is so reimbursed. In lieu
               thereof, the Company shall have the right to

- ---------------------
        (2) "This rate is based on the rate for the year set forth in the Code
at the time of the first payment to the participant.

                                       5
<PAGE>   14

               withhold from any other cash amounts due (or to become due) to
               the Grantee an amount equal to such taxes required to be withheld
               by the Company to reimburse the Company for any such taxes, or
               the Company may retain and withhold a number of shares of Common
               Stock having a market value not less than the amount of such
               taxes and cancel (in whole or in part) any shares of Common Stock
               so withheld in order to reimburse the Company for any such taxes.

                                    SECTION 9
                            IMPACT ON OTHER BENEFITS

        9.1    The value of the Option (either on the date of grant of the
               Option or at the time the shares are vested) shall not be
               includable as compensation or earnings for purposes of any other
               benefit plan offered by the Company.

                                   SECTION 10
                                 ADMINISTRATION

        10.1   The Committee shall have full authority and discretion to decide
               all matters relating to the administration and interpretation of
               this Agreement. All such Committee determinations shall be final,
               conclusive and binding upon the Company, the Grantee and any and
               all interested parties.

                                   SECTION 11
                       AGREEMENT TO CONTINUE IN EMPLOYMENT
                           OR SERVICE AS A CONSULTANT

        11.1   Nothing in this Agreement shall confer on a Grantee any right to
               continue in the employ of the Company or in the service of the
               Company as a consultant or interfere in any way with the right of
               the Company to terminate such consulting relationship at any
               time.

                                   SECTION 12
                                  AMENDMENT(S)

        12.1   This Agreement may not in any way be amended or terminated
               without the Grantee's written consent.

                                   SECTION 13
                                FORCE AND EFFECT

        13.1   The various provisions of this Agreement are severable in their
               entirety. Any determination of invalidity or unenforceability of
               any one provision shall have no effect on the continuing force
               and effect of the remaining provisions.



                                       6
<PAGE>   15


                                   SECTION 14
                         NOTICE OF DISPOSITION OF SHARES

        14.1   The Grantee agrees that if it should dispose of any shares of
               Common Stock acquired on the exercise of the Option, including a
               disposition by sale, exchange, gift or transfer of legal title
               within twelve (12) months of the date such shares are transferred
               to the Grantee, the Grantee will notify the Company promptly of
               such disposition.

                                   SECTION 15
                                     NOTICES

        15.1   All notices which may be or are required to be given by one party
               to the other party pursuant to this Agreement shall be in writing
               and shall be mailed by first class or certified mail, return
               receipt requested, postage prepaid, or transmitted by hand
               delivery as follows:

               If to the Company:   DUSA Pharmaceuticals, Inc.
                                    181 University Avenue
                                    Suite 1208
                                    Toronto, ON M5H 3M7
                                    CANADA

                                    Attention:  Dr. D. Geoffrey Shulman

               If to the Grantee:   Ronald L. Carroll
                                    166 Otis Street
                                    Hingham, Massachusetts 02043

               or such other address as to which either party may from time to
               time notify the other as aforesaid.

                                   SECTION 16
                            RESTRICTIONS ON TRANSFER

        16.1   The Grantee understands and acknowledges that it is subject to
               certain restrictions on transfer under the Securities Act of 1933
               of the United States, as amended, (the "1933 Act") of the shares
               issued pursuant to the exercise of the Option; such restrictions
               provide that the shares may not be sold without registration or
               exemption from registration under the 1933 Act.

                                   SECTION 17
                             REPORTING REQUIREMENTS

        17.1   The Grantee understands and acknowledges that it may be subject
               to certain reporting requirements upon its receipt and exercise
               of the Option, and in


                                       7
<PAGE>   16

               connection therewith, upon the receipt and exercise of the
               Option, the Grantee agrees to timely file with the Securities and
               Exchange Commission, the National Association of Securities
               Dealers, Inc., and any appropriate Canadian securities regulatory
               authorities, the appropriate documentation regarding his
               ownership of the Company's securities.

                                   SECTION 18
                                  GOVERNING LAW

        18.1   This Agreement shall be construed and enforced in accordance with
               and governed by the laws of the State of New Jersey.

        IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
hereto.

Attest:                                DUSA PHARMACEUTICALS, INC.,
                                       a New Jersey corporation


s/Nanette W. Mantell                   By:  s/D. Geoffrey Shulman
- ----------------------------------         -------------------------------
Nanette W. Mantell, Secretary              Dr. D. Geoffrey Shulman, President


                                       PARTICIPANT


                                       s/ Ronald L. Carroll
                                       -----------------------------------
                                       Ronald L. Carroll


                                       8
<PAGE>   17


                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:     The Secretary of DUSA Pharmaceuticals, Inc.

        Pursuant to the terms and subject to the conditions set forth in the
Nonqualified Stock Option Agreement (the "Agreement") dated       , between DUSA
Pharmaceuticals, Inc. and the undersigned, and the Option granted to the
undersigned by such Agreement, I hereby elect to purchase           shares of
Common Stock of DUSA Pharmaceuticals, Inc. which were the subject of such
Option. I understand that such purchase is subject to all the terms and
conditions of the Agreement. I request that the certificates for such shares of
Common Stock shall be issued in the name of:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

        The undersigned hereby represents and warrants to, and agrees with the
Company as follows:

        (a) The shares are being purchased for the undersigned's own account,
for investment purposes only, and not for the account of any other person, and
not with a view to distribution, assignment, or resale to others, or to
fractionalization in whole or in part and that the offering and sale of the
shares is intended to be exempt from registration under the Securities Act of
1933 (the "Act"). In furtherance thereof, the undersigned represents, warrants
and agrees as follows: (i) no other person has or will have a direct or indirect
beneficial interest in such shares and the undersigned will not sell,
hypothecate, or otherwise transfer his shares except in accordance with the Act
and applicable state securities laws or unless in the opinion of counsel for the
Company, an exemption from the registration requirements of the Act and such
laws is available; and (ii) the Company is under no obligation to register the
shares on behalf of the undersigned or to assist the undersigned in complying
with any exemption from registration.


<PAGE>   18

        (b) The undersigned has such knowledge and experience in financial and
business matters that the undersigned is capable of evaluating the merits and
risks of investment in the Company and of making an informed investment
decision.

        In full payment of the purchase price with respect to the Option
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian or
United States currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                  X
                         --------------------------------------
                                       (Signature)

                                -------------------------------------
                                       Name (Please Print)

                                -------------------------------------
                                       (Address)

                                -------------------------------------
                                       Taxpayer Identification Number



<PAGE>   1
                                                                 Exhibit 4.15(a)

                             STOCK OPTION AGREEMENT

        THIS AGREEMENT is made as of the 14 day of April, 1994 between DUSA
PHARMACEUTICALS, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and SCOTT LUNDAHL, who
resides at 4 Morris Street, Lexington, Massachusetts 02173 (hereinafter referred
to as the "Participant").

                                   WITNESSETH:

        WHEREAS, the Company granted on April 14, 1994 (the "Grant Date") to
Lumenetics, Inc., a corporation incorporated under the laws of the State of
Delaware, ("Lumenetics") stock options for 20,000 shares of the Company's common
stock (the "Options"); and

        WHEREAS, Lumenetics has determined to assign its interest in the Options
to Ronald L. Carroll and Scott Lundahl, the principal shareholders of
Lumenetics; and

        WHEREAS, the Company has determined that it is in the Company's interest
to acknowledge the assignment by Lumenetics of the Options to purchase shares of
the Company's common stock ("Shares") on the terms and conditions set forth in
this Agreement.

        NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:

1.1     DEFINITIONS

        In this Agreement:

        "Board of Directors" means the board of directors of the Company;

        "Exercise Price" means U.S. $3.625;

        "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later
        of the dates provided in Section 2.2;

        "Optioned Shares" means that number of Shares which are subject to the
        option granted by the Company to the Participant pursuant to this
        Agreement;

        "Services" means consulting or other services provided by the
        Participant to the Company; and

        "Shares" means shares of common stock, without par value, of the
Company.


<PAGE>   2

2.1     GRANT OF OPTION

        The Company hereby grants to the Participant an option to purchase, in
        accordance with the vesting rights outlined in Sections 2.6 and 2.7
        hereof, up to 10,000 SHARES for an amount per Share equal to the
        Exercise Price, upon the terms and subject to the conditions herein
        contained.

2.2     Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have
        the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on the
        tenth (10th) anniversary date hereof, being April 14, 2004 (provided
        that if such day is not a day on which the Company is open for business
        then on the first following day on which the Company is open for
        business) to exercise this option for any number of the Optioned Shares
        up to the maximum number of Shares specified in Section 2.1 above.

2.3     The option may be exercised by the Participant or by his executors or
        personal representatives in the circumstances described in Section 4.1
        by providing to the Company notice in writing in the form of Schedule A
        hereto setting out the number of Optioned Shares with respect to which
        the option is being exercised. The notice must be accompanied by a
        certified check, official bank cashier's check or money order in an
        amount equal to the Exercise Price multiplied by the number of Shares
        requested and a duly executed copy of this Agreement.

2.4     The Company shall cause its registrar and transfer agent to deliver to
        the Participant as soon as practicable after receipt of such notice and
        payment a certificate or certificates registered in the name of the
        Participant or as the Participant may direct for the number of Shares
        with respect to which the option is duly exercised.

2.5     Nothing contained in this Agreement or action taken pursuant hereto
        shall obligate the Participant to purchase and/or pay for, or the
        Company to issue, any Shares except those Optioned Shares with respect
        to which the Participant shall have duly exercised the option to
        purchase in accordance with this Agreement.

2.6     Subject to Section 2.7 hereof, the option granted hereunder shall vest
        in the following manner:

        (a)    one-quarter of the option on the first anniversary of the day
               immediately preceding the date hereof, being April 13, 1995;

        (b)    one-quarter of the option on the second anniversary of the day
               immediately preceding the date hereof, being April 13, 1996;

        (c)    one-quarter of the option on the third anniversary of the day
               immediately preceding the date hereof, being April 13, 1997; and

        (d)    one-quarter of the option on the fourth anniversary of the day
               immediately preceding the date hereof, being April 13, 1998;

                                       2
<PAGE>   3


        and, except as provided by Section 6.1, the Participant shall only be
        entitled to exercise this option in the amounts set out above and from
        and after the dates so specified.

2.7     Notwithstanding anything contained in Section 2.6 hereof, the option
        shall continue to vest only so long as the Participant continues to
        provide Services to the Company. Should the Participant cease to provide
        such Services ("Termination"), no further vesting of the option shall
        occur unless the Board of Directors determines otherwise and the
        provisions of Section 3.1 shall apply with respect to the exercise of
        the option to the extent that it has vested and has not yet been
        exercised.

3.1     EXPIRATION ON TERMINATION

        Subject to Section 4.1 hereof, upon Termination, such part of the option
        as is then vested but unexercised may be exercised by the Participant
        for a period of ninety (90) days after Termination or such later date as
        the Board of Directors may approve after which time this option shall
        expire; provided, however, that in no event may this option be exercised
        after the Expiration Date.

4.1     DEATH OR PERMANENT DISABILITY

        In the event that on or prior to the Expiration Date, the Participant
        dies or becomes totally and permanently disabled while providing
        Services to the Company, this option, to the extent then vested but
        unexercised, may be exercised by the Participant for a period up to six
        (6) months after the death or disability of the Participant; provided,
        however, that in no event may this option be exercised after the
        Expiration Date. Disability shall be defined as in Section 22(e)(3) of
        the Internal Revenue Code of 1986, as amended. For the purposes of this
        provision only, reference to the Participant in this Agreement shall be
        construed as including the executors or personal representatives of a
        deceased Participant. In the event that this option is not exercised
        within the period of six (6) months set out above, this option shall
        expire.

5.1     SUBDIVISION, CONSOLIDATION OR REORGANIZATION

        (a) In the event of any subdivision, redivision or change of the Shares
        of the Company into a greater number of Shares at any time after the
        date of this Agreement and prior to the Expiration Date of this option,
        the Company shall deliver at the time of exercise of this option, but
        for the same aggregate consideration payable therefor, such additional
        number of Shares as the Participant would have been entitled to receive
        as a result of such subdivision, redivision or change if on the record
        date thereof the Participant had been the registered holder of the
        number of such Shares with respect to which the option is later
        exercised.

        (b) In the event of any consolidation or change of the Shares of the
        Company into a lesser number of Shares at any time after the date of
        this Agreement and prior to the expiration of this option, the Company
        shall deliver at the time of exercise of this option, but for the same
        aggregate consideration payable therefor, such reduced number of Shares,
        as the Participant would have been entitled to receive upon such
        consolidation or change if on



                                       3
<PAGE>   4



        the record date thereof the Participant had been the registered holder
        of the number of such Shares with respect to which the option is later
        exercised.

        (c) If at any time after the date of this Agreement and prior to the
        expiration of this option, the Shares shall be reclassified or
        reorganized, otherwise than as specified in Sections 5.1(a) and (b), the
        Participant shall be entitled to receive upon the exercise of this
        option and shall accept in lieu of the number of Shares then subscribed
        for, but for the same aggregate consideration payable therefor, the same
        aggregate number of shares of the appropriate class of shares that the
        Participant would have been entitled to receive as a result of such
        reclassification or other reorganization of Shares if on the record date
        thereof the Participant had been the registered holder of the number of
        such Shares with respect to which the option is later exercised.

6.1     TAKE-OVER BID

        If an offeror makes an offer to purchase 50% or more of the outstanding
        Shares to substantially all holders of the Shares or, if an insider of
        the Company makes an offer to purchase Shares to substantially all
        holders of the Shares, and the Board of Directors recommends acceptance
        of such offer to the shareholders of the Company and the offer price is
        greater than the Exercise Price, then this option, whether or not it has
        vested in whole or in part, shall become immediately exercisable. The
        Participant shall be bound to exercise this option and to tender the
        Optioned Shares issued upon exercise of this option into the offer upon
        receipt of notice from the Company if the Company provides an
        interest-free loan to the Participant in the amount of the Exercise
        Price for all of the Optioned Shares issuable upon exercise of this
        option, subject to the execution of a security agreement by the
        Participant in favor of the Company securing repayment of the loan.

7.1     NO ASSIGNMENT

        The Participant may not assign, transfer, pledge or hypothecate any of
        his rights hereunder in any way (whether by operation of law or
        otherwise) except by will or by the laws of succession on intestacy
        which may apply to the estate of the Participant upon his death. The
        option granted herein shall not be subject to execution, attachment or
        similar process. Upon any attempt to assign, transfer, pledge,
        hypothecate or otherwise dispose of this option contrary to the
        provisions hereof, or upon the levy of any attachment or similar process
        upon the option granted herein, such option shall immediately become
        void.

8.1     GENERAL

        (a) Time shall be of the essence of this Agreement.

        (b) In this Agreement, words importing the singular number include the
        plural and vice versa and words importing the masculine gender include
        the feminine and neuter genders.

        (c) All notices which may be or are required to be given by one party to
        the other party pursuant to this Agreement shall be in writing and shall
        be mailed by first class or certified mail, return receipt requested,
        postage prepaid, or transmitted by hand delivery as follows:



                                       4
<PAGE>   5


<TABLE>
<S>                                     <C>
        If to the Company:                  DUSA Pharmaceuticals, Inc.
                                            181 University Avenue, Suite 1208
                                            Toronto, ON M5H 3M7
                                            CANADA

                                            Attention:  Dr. D. Geoffrey Shulman

               with a copy to:              Nanette W. Mantell, Esq., Corporate Secretary
                                            Lane and Mantell
                                            991 Route 22 West
                                            PO Box 8539
                                            Somerville, NJ 08876
                                            U.S.A.

        If to the Participant:              at the address of the Participant
                                            from time to time in the records of the Company,
</TABLE>

        or such other address as to which either party may from time to time
        notify the other as aforesaid.

9.1     RESTRICTIONS ON TRANSFER

        The Participant understands and acknowledges that the option and Shares
        underlying the option have not been registered and that they are subject
        to certain restrictions on transfer under the Securities Act of 1933 of
        the United States, as amended, (the "1933 Act"); such restrictions
        provide that the Shares may not be sold without registration or
        exemption from registration under the 1933 Act; and, for purposes of the
        Securities Act (Ontario) (the "Ontario Act"), the first trade of the
        Shares issued pursuant to the exercise of the option, other than a trade
        exempted by the Ontario Act, will be a distribution unless the Company
        has been a reporting issuer for at least twelve (12) months and the
        Company is not in default of any requirement of the Ontario Act,
        disclosure has been made to the Ontario Securities Commission of the
        exempt trade, no unusual effort is made to prepare the market or create
        a demand for the Shares, and no extraordinary commission or
        consideration is paid with respect to the trade, provided that such
        first trade is not from the holdings of a so-called "control block".



                                       5
<PAGE>   6


        IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
hereto.

Attest:                                  DUSA PHARMACEUTICALS, INC.
                                         a New Jersey corporation


s/Nanette W. Mantell                     By:  s/D. Geoffrey Shulman
- -------------------------------------        -------------------------------
Nanette W. Mantell, Secretary                Dr. D. Geoffrey Shulman, President


                                         PARTICIPANT


                                         s/ Scott Lundahl
                                         -----------------------------------
                                         Scott Lundahl



                                       6
<PAGE>   7


                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:     The Secretary of DUSA Pharmaceuticals, Inc.

        Pursuant to the terms and subject to the conditions set forth in the
Stock Option Agreement (the "Agreement") dated         , between DUSA
Pharmaceuticals, Inc. and the undersigned, I hereby elect to purchase     shares
of Common Stock of DUSA Pharmaceuticals, Inc. I understand that such purchase is
subject to all the terms and conditions of the Agreement. I request that the
certificates for such shares of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

        In full payment of the purchase price with respect to the Optioned
Shares exercised, the undersigned hereby tenders payment of $___________ by
certified check or official bank cashier's check or money order payable in
Canadian currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                             X
                                    --------------------------------------
                                          (Signature)

                                          -------------------------------------
                                          Name (Please Print)

                                          -------------------------------------
                                          (Address)

                                          -------------------------------------
                                          Taxpayer Identification Number


<PAGE>   8
                                                                 Exhibit 4.15(b)

                       NONQUALIFIED STOCK OPTION AGREEMENT

        AGREEMENT made and entered into as of the 13TH day of MARCH, 1997, by
and between DUSA Pharmaceuticals, Inc., a corporation incorporated under the
laws of the State of New Jersey (the "Company"), and SCOTT LUNDAHL, who resides
at 4 Morris Street, Lexington, Massachusetts 02173 (the "Grantee").

        WHEREAS, the Company granted on March 13, 1997 (the "Grant Date") to
Lumenetics, Inc., a corporation incorporated under the laws of the State of
Delaware, ("Lumenetics") stock options for 100,000 shares of the Company's
common stock (the "Options"); and

        WHEREAS, Lumenetics has determined to assign its interest in the Options
to Ronald L. Carroll and Scott Lundahl, the principal shareholders of
Lumenetics; and

        WHEREAS, the Company has determined that its interests will be advanced
by acknowledging the assignment by Lumenetics of the Options.

        NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, the parties hereby agree as follows:

                                    SECTION 1
                                      GRANT

        1.1    The Company hereby acknowledges the assignment to the Grantee of
               the right and option (the "Option") to purchase, in accordance
               with the vesting rights outlined in Sections 3.1 and 3.6 hereof,
               up to 50,000 shares of authorized but unissued Common Stock,
               without par value ("Common Stock"), of the Company on the terms
               and conditions herein set forth in this Agreement.

                                    SECTION 2
                                      PRICE

        2.1    The purchase price of the shares of Common Stock subject to this
               Option shall be the fair market value of the shares of Common
               Stock on the Grant Date ($6.125 per share)(the "Exercise Price").

                                    SECTION 3
                                WHEN EXERCISABLE

        3.1    The aggregate number of shares of Common Stock of the Company
               optioned by this Agreement (the "Optioned Shares") shall vest in
               the Grantee as follows:

               (a)    25% of the Option on the day of the grant, being March 13,
               1997;


<PAGE>   9

               (b)    25% of the Option on the second anniversary of the day of
                      grant, being March 13, 1999;

               (c)    25% of the Option on the third anniversary of the day of
                      the grant, being March 13, 2000;

               (d)    25% of the Option on the fourth anniversary of the day of
                      the grant, being March 13, 2001; and

        and, except as provided by Sections 3.6 and 6.3 hereof, the Grantee
        shall only be entitled to exercise this Option, in whole or in part, in
        the amounts set out above and from and after the dates so specified.

        3.2    Subject to Sections 3.1 and 3.6 hereof, the Grantee shall have
               the right, at any time prior to 5:00 p.m. (Eastern Standard Time)
               on the date prior to the tenth anniversary date of the grant,
               being March 12, 2007, provided that if such day is not a day on
               which the Company is open for business then on the first
               following day on which the Company is open for business, to
               exercise this Option for any number of the Optioned Shares up to
               the maximum number of shares specified in Section 1.1 above.

        3.3    No less than one thousand (1,000) shares may be purchased upon
               any one exercise of the Option granted hereby unless the number
               of shares purchased at such time is the total number of shares in
               respect of which the Option hereby granted is then exercisable.

        3.4    In no event shall any Option granted hereby be exercisable for a
               fractional share.

        3.5    From time to time, in its discretion, the Company's Stock Option
               Committee (the "Committee") may offer the Grantee the right to
               cancel any Option granted hereunder in exchange for such
               consideration as the Committee shall determine.

        3.6    Notwithstanding anything contained in Sections 1 and 3.1 hereof,
               the Option shall continue to vest in the Grantee as provided by
               the terms of Paragraph 3(d)(ii) of the Consulting and Development
               Agreement, dated October 14, 1997 (the "Consulting Agreement")
               between the Company and Lumenetics, which Consulting Agreement
               was subsequently partially terminated pursuant to a certain
               Partial Termination Agreement dated as of the February 25, 1999.
               The Board of Directors shall be entitled to determine if and when
               service to the Company has ceased with respect to the Grantee.

                                    SECTION 4
                                 HOW EXERCISABLE

        4.1    Subject to such administrative regulations as the Committee may
               from time to time adopt, the Grantee or beneficiary shall, in
               order to exercise this Option give to the Company at its
               principal office notice in writing in the form of Schedule A
               hereto setting out the number of Optioned Shares with respect to



                                       2
<PAGE>   10


               which the Option is being exercised. The notice must be
               accompanied by payment of a certified check, official bank
               cashier's check or money order in an amount equal to the Exercise
               Price multiplied by the number of shares requested and a duly
               executed copy of this Agreement. At the discretion of the
               Committee, the Grantee may pay all or a portion of the purchase
               price by tender of Common Stock or a combination of stock and
               cash or other means determined by the Committee.

        4.2    Any notice under this Section shall include an undertaking to
               furnish or execute such documents as the Committee in its
               discretion shall deem necessary (i) to evidence such exercise, in
               whole or in part, of the Option evidenced by this Agreement, (ii)
               to determine whether registration is then required under the
               Securities Act of 1933, or any other law, as then in effect, and
               (iii) to comply with or satisfy the requirements of the
               Securities Act of 1933, or any other law, as then in effect.

        4.3    The Grantee agrees that all shares purchased by it under the
               Option will be acquired for investment, not distribution, and
               that any notice of exercise of the Option must be accompanied by
               a written representation to that effect, signed by the Grantee.

                                    SECTION 5
                              TERMINATION OF OPTION

        5.1    The Option granted hereby shall terminate and be of no force or
               effect upon the expiration of ten years from the date of the
               Grant unless terminated prior to such time as provided below.

        5.2    Any determination made by the Committee with respect to any
               matter referred to in this Section 5 shall be final and
               conclusive on all persons affected thereby. Service to the
               Company shall be deemed to include service to any subsidiary of
               the Company by the Grantee.

                                    SECTION 6
                              ADJUSTMENTS TO OPTION

        6.1    Subject to any required action by the Committee and shareholders,
               the number of shares provided for in the Option, and the price
               per share thereof shall be proportionately adjusted for any
               increase or decrease in the number of issued shares of the
               Company resulting from the payment of a share dividend, a share
               split or any transaction which is a "corporate transaction" (as
               defined in the Treasury regulations promulgated under Section 424
               of the Code.

        6.2    Subject to any required action by the Committee and shareholders,
               if the Company shall be the surviving entity in any merger or
               consolidation, or after a consolidation of the Company and one or
               more entities in which the resulting entity is an independent
               entity, the Option shall pertain to and apply to the


                                       3
<PAGE>   11

               securities of the surviving entity in an amount that the board of
               directors of the surviving entity, at its sole discretion,
               determines to be equivalent, as nearly as practicable, to the
               nearest whole number and class of shares that were subject to the
               Option. These shares of stock or other securities shall, after
               such merger or consolidation, be deemed to be shares for all
               purposes hereof. The aforesaid adjustments, when applicable,
               shall be made by the Committee, and the Committee's determination
               shall be final, binding and conclusive.

        6.3    In the event of a Change of Control (as defined below), any and
               all outstanding Options not fully vested shall automatically vest
               in full and shall be immediately exercisable. The date on which
               such accelerated vesting and immediate exercisability shall occur
               shall be the date of the occurrence of the Change of Control.

               A "Change of Control" shall be deemed to have taken place upon
               (i) the acquisition by a third person, including a "group" as
               defined in Section 13(d)(3) of the Securities Exchange Act of
               1934, as amended, of shares of the Company having 50% or more of
               the total number of votes that may be cast for the election of
               Directors of the Company; (ii) shareholder approval of a
               transaction for the acquisition of the Company, or substantially
               all of its assets by another entity or for a merger,
               reorganization, consolidation or other business combination to
               which the Company is a part; or (iii) the election during any
               period of 24 months or less of 50% or more of the Directors of
               the Company where such Directors were not in office immediately
               prior to such period provided, however, that no "Change of
               Control" shall be deemed to have taken place if the Directors of
               the Company in office on the date of adoption of the Plan, or
               their successors in office nominated by such Directors,
               affirmatively approve a resolution to such effect.

               Except as provided with respect to a Grantee in its stock option
               agreement or other controlling agreement between it and the
               Company, to the extent that the acceleration, exercisability or
               parachute payment attributable to the Option following a Change
               of Control would result in "excess parachute payments"(1) when
               the former are aggregated with other payments or benefits to the
               Grantee, such parachute payments or benefits provided to a
               Grantee under this Agreement shall be reduced to the extent
               necessary so that no portion thereof shall be subject to the
               excise tax imposed by Section 4999 of the Code. This reduction
               will only be made if it will cause the Grantee's net after-tax
               benefit to exceed the net after-tax benefit that would have
               existed if such reduction were not made. "Net after-tax benefit"
               shall be the sum of (i) all payments and benefits which a Grantee
               receives or is entitled to receive that would constitute a
               "parachute payment" under Section 280G of the Code, less (ii) the
               amount of federal income taxes payable with respect to the
               payments and benefits described in (i) above,

- -------------------
        (1) "Excess parachute payments" are defined in Section 280G of the Code
and are determined by tax counsel of the Company.


                                       4
<PAGE>   12

               calculated at the maximum marginal income tax rate(2) for the
               year in which such payments and benefits shall be paid to the
               Grantee, less (iii) the amount of excise taxes imposed with
               respect to the payments and benefits described in (i) above by
               Section 4999 of the Code.

        6.4    In the event of a change in the Company's shares which is limited
               to a change of all of its authorized shares with par value into
               the same number of shares with a different par value or without
               par value, the shares resulting from any such change shall be
               deemed to be shares within the meaning of this Agreement.

        6.5    Except as herein before expressly provided in Paragraphs 6.1,
               6.2, 6.3 and 6.4 of this Section 6, the Grantee shall have no
               rights by reason of any subdivision or consolidation of shares of
               any class or payment of any share dividend or any other increase
               or decrease in the number of shares of any class or by reason of
               any dissolution, liquidation, merger, consolidation or spin-off
               of assets or stock of another corporation and any issuance by the
               Company of shares of any class, or securities convertible into
               shares of any class, shall not affect the Option, and no
               adjustment by reason thereof shall be made with respect to the
               number or price of the Company's shares subject to the Option.
               The grant of the Option shall not affect in any way the right or
               power of the Company to make adjustments, reclassifications,
               reorganizations or changes of its capital or business structure
               or to merge, consolidate, dissolve, liquidate, sell or transfer
               all or any part of its business or assets.

                                    SECTION 7
                                    TRANSFER

        7.1    This Option shall not be transferable by the Grantee in any way.
               During the existence of the Grantee, the Option shall be
               exercisable only by it. Any other attempted assignment, transfer,
               pledge, hypothecation or other disposition of the Option shall be
               void and have no effect unless in accordance with the terms set
               forth herein.

                                    SECTION 8
                                WITHHOLDING TAXES

        8.1    The Company shall have the right to retain and withhold from any
               payment, under the Option granted, any amount that is to be
               withheld or otherwise deducted and paid with respect to such
               payment. At its discretion, the Company may require the Grantee,
               if it receives shares under a nonqualified stock option grant, to
               reimburse the Company for any taxes that are required to be
               withheld by the Company, and may withhold any distribution in
               whole or in part until the Company is so reimbursed. In lieu
               thereof, the Company shall have the right to

- ----------------------
        (2) "This rate is based on the rate for the year set forth in the Code
at the time of the first payment to the participant.



                                       5
<PAGE>   13

               withhold from any other cash amounts due (or to become due) to
               the Grantee an amount equal to such taxes required to be withheld
               by the Company to reimburse the Company for any such taxes, or
               the Company may retain and withhold a number of shares of Common
               Stock having a market value not less than the amount of such
               taxes and cancel (in whole or in part) any shares of Common Stock
               so withheld in order to reimburse the Company for any such taxes.

                                    SECTION 9
                            IMPACT ON OTHER BENEFITS

        9.1    The value of the Option (either on the date of grant of the
               Option or at the time the shares are vested) shall not be
               includable as compensation or earnings for purposes of any other
               benefit plan offered by the Company.

                                   SECTION 10
                                 ADMINISTRATION

        10.1   The Committee shall have full authority and discretion to decide
               all matters relating to the administration and interpretation of
               this Agreement. All such Committee determinations shall be final,
               conclusive and binding upon the Company, the Grantee and any and
               all interested parties.

                                   SECTION 11
                       AGREEMENT TO CONTINUE IN EMPLOYMENT
                           OR SERVICE AS A CONSULTANT

        11.1   Nothing in this Agreement shall confer on a Grantee any right to
               continue in the employ of the Company or in the service of the
               Company as a consultant or interfere in any way with the right of
               the Company to terminate such consulting relationship at any
               time.

                                   SECTION 12
                                  AMENDMENT(S)

        12.1   This Agreement may not in any way be amended or terminated
               without the Grantee's written consent.

                                   SECTION 13
                                FORCE AND EFFECT

        13.1   The various provisions of this Agreement are severable in their
               entirety. Any determination of invalidity or unenforceability of
               any one provision shall have no effect on the continuing force
               and effect of the remaining provisions.



                                       6
<PAGE>   14


                                   SECTION 14
                         NOTICE OF DISPOSITION OF SHARES

        14.1   The Grantee agrees that if it should dispose of any shares of
               Common Stock acquired on the exercise of the Option, including a
               disposition by sale, exchange, gift or transfer of legal title
               within twelve (12) months of the date such shares are transferred
               to the Grantee, the Grantee will notify the Company promptly of
               such disposition.

                                   SECTION 15
                                     NOTICES

        15.1   All notices which may be or are required to be given by one party
               to the other party pursuant to this Agreement shall be in writing
               and shall be mailed by first class or certified mail, return
               receipt requested, postage prepaid, or transmitted by hand
               delivery as follows:

               If to the Company:   DUSA Pharmaceuticals, Inc.
                                    181 University Avenue
                                    Suite 1208
                                    Toronto, ON M5H 3M7
                                    CANADA

                                    Attention:  Dr. D. Geoffrey Shulman

               If to the Grantee:   Scott Lundahl
                                    4 Morris Street
                                    Lexington, Massachusetts 02173

               or such other address as to which either party may from time to
               time notify the other as aforesaid.

                                   SECTION 16
                            RESTRICTIONS ON TRANSFER

        16.1   The Grantee understands and acknowledges that it is subject to
               certain restrictions on transfer under the Securities Act of 1933
               of the United States, as amended, (the "1933 Act") of the shares
               issued pursuant to the exercise of the Option; such restrictions
               provide that the shares may not be sold without registration or
               exemption from registration under the 1933 Act.

                                   SECTION 17
                             REPORTING REQUIREMENTS

        17.1   The Grantee understands and acknowledges that it may be subject
               to certain reporting requirements upon its receipt and exercise
               of the Option, and in



                                       7
<PAGE>   15

               connection therewith, upon the receipt and exercise of the
               Option, the Grantee agrees to timely file with the Securities and
               Exchange Commission, the National Association of Securities
               Dealers, Inc., and any appropriate Canadian securities regulatory
               authorities, the appropriate documentation regarding his
               ownership of the Company's securities.

                                   SECTION 18
                                  GOVERNING LAW

        18.1   This Agreement shall be construed and enforced in accordance with
               and governed by the laws of the State of New Jersey.

        IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
hereto.

Attest:                                            DUSA PHARMACEUTICALS, INC.,
                                                   a New Jersey corporation


s/Nanette W. Mantell                     By:  s/D. Geoffrey Shulman
- -----------------------------------          -------------------------------
Nanette W. Mantell, Secretary                Dr. D. Geoffrey Shulman, President


                                         PARTICIPANT


                                         s/ Scott Lundahl
                                         -----------------------------------
                                         Scott Lundahl



                                       8
<PAGE>   16



                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:     The Secretary of DUSA Pharmaceuticals, Inc.

        Pursuant to the terms and subject to the conditions set forth in the
Nonqualified Stock Option Agreement (the "Agreement") dated      , between DUSA
Pharmaceuticals, Inc. and the undersigned, and the Option granted to the
undersigned by such Agreement, I hereby elect to purchase      shares of Common
Stock of DUSA Pharmaceuticals, Inc. which were the subject of such Option. I
understand that such purchase is subject to all the terms and conditions of the
Agreement. I request that the certificates for such shares of Common Stock shall
be issued in the name of:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

        The undersigned hereby represents and warrants to, and agrees with the
Company as follows:

        (a) The shares are being purchased for the undersigned's own account,
for investment purposes only, and not for the account of any other person, and
not with a view to distribution, assignment, or resale to others, or to
fractionalization in whole or in part and that the offering and sale of the
shares is intended to be exempt from registration under the Securities Act of
1933 (the "Act"). In furtherance thereof, the undersigned represents, warrants
and agrees as follows: (i) no other person has or will have a direct or indirect
beneficial interest in such shares and the undersigned will not sell,
hypothecate, or otherwise transfer his shares except in accordance with the Act
and applicable state securities laws or unless in the opinion of counsel for the
Company, an exemption from the registration requirements of the Act and such
laws is available; and (ii) the Company is under no obligation to register the
shares on behalf of the undersigned or to assist the undersigned in complying
with any exemption from registration.


<PAGE>   17


        (b) The undersigned has such knowledge and experience in financial and
business matters that the undersigned is capable of evaluating the merits and
risks of investment in the Company and of making an informed investment
decision.

        In full payment of the purchase price with respect to the Option
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian or
United States currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                          X
                                 -----------------------------------------
                                               (Signature)

                                        -------------------------------------
                                               Name (Please Print)

                                        -------------------------------------
                                               (Address)

                                        -------------------------------------
                                               Taxpayer Identification Number


<PAGE>   1

                                                                    Exhibit 4.16


                       NONQUALIFIED STOCK OPTION AGREEMENT
                           DUSA PHARMACEUTICALS, INC.

     AGREEMENT made and entered into as of the 13TH day of MARCH, 1997, by and
between DUSA Pharmaceuticals, Inc., a corporation incorporated under the laws of
the State of New Jersey (the "Company"), and DANIEL PIACQUADIO, with an address
c/o Therapeutics, Inc., 4180 La Jolla Village Drive, Suite 210, La Jolla,
California 92037 (the "Grantee").

     WHEREAS, the Company granted on March 13, 1997 (the "Grant Date") to
THERAPEUTICS, INC., a corporation with offices in the State of California,
("Therapeutics") stock options for 15,000 shares of the Company's common stock
(the "Options"); and

     WHEREAS, Therapeutics has determined to assign its interest in the Options
to the Grantee, its principal shareholder, and the individual providing services
to the Company; and

     WHEREAS, the Company has determined that its interests will be advanced by
acknowledging the assignment by Therapeutics of the Options.

     NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, the parties hereby agree as follows:


                                    SECTION 1
                                      GRANT

     1.1  The Company hereby acknowledges the assignment to the Grantee of the
          right and option (the "Option") to purchase, in accordance with the
          vesting rights outlined in Sections 3.1 and 3.6 hereof, up to 15,000
          shares of authorized but unissued Common Stock, without par value
          ("Common Stock"), of the Company on the terms and conditions herein
          set forth in this Agreement.


                                    SECTION 2
                                      PRICE

     2.1  The purchase price of the shares of Common Stock subject to this
          Option shall be the fair market value of the shares of Common Stock on
          the Grant Date ($6.125 per share)(the "Exercise Price").


                                    SECTION 3
                                WHEN EXERCISABLE

     3.1  The aggregate number of shares of Common Stock of the Company optioned
          by this Agreement (the "Optioned Shares") shall vest in the Grantee as
          follows:
<PAGE>   2
          (a)  20% of the Option shall vest as of June 14, 1997;

          (b)  20% of the Option on June 14, 1998;

          (c)  20% of the Option on June 14, 1999;

          (d)  20% of the Option on June 14, 2000; and

          (e)  20% of the Option on June 14, 2001;

and, except as provided by Sections 3.6 and 6.3 hereof, the Grantee shall only
be entitled to exercise this Option, in whole or in part, in the amounts set out
above and from and after the dates so specified.

     3.2  Subject to Sections 3.1 and 3.6 hereof, the Grantee shall have the
          right, at any time prior to 5:00 p.m. (Eastern Standard Time) on March
          13, 2007, provided that if such day is not a day on which the Company
          is open for business then on the first following day on which the
          Company is open for business, to exercise this Option for any number
          of the Optioned Shares up to the maximum number of shares specified in
          Section 1.1 above.

     3.3  No less than one thousand (1,000) shares may be purchased upon any one
          exercise of the Option granted hereby unless the number of shares
          purchased at such time is the total number of shares in respect of
          which the Option hereby granted is then exercisable.

     3.4  In no event shall any Option granted hereby be exercisable for a
          fractional share.

     3.5  From time to time, in its discretion, the Company's Stock Option
          Committee (the "Committee") may offer the Grantee the right to cancel
          any Option granted hereunder in exchange for such consideration as the
          Committee shall determine.

     3.6  Notwithstanding anything contained in Sections 1 and 3.1 hereof, the
          Option shall continue to vest in the Grantee only so long as the
          Grantee shall continue to provide services to the Company. Should the
          Grantee cease to serve the Company, the Option shall not further vest
          or become exercisable, and the provisions of Section 5.2 shall apply
          with respect to the exercise of the Option which has already vested in
          the Grantee and has not yet been exercised. The Board of Directors
          shall be entitled to determine if and when service to the Company has
          ceased with respect to the Grantee.


                                    SECTION 4
                                 HOW EXERCISABLE

     4.1  Subject to such administrative regulations as the Committee may from
          time to time adopt, the Grantee or beneficiary shall, in order to
          exercise this Option give to the Company at its principal office
          notice in writing in the form of Schedule A hereto setting out the
          number of Optioned Shares with respect to which the Option is being

                                       2
<PAGE>   3
          exercised. The notice must be accompanied by payment of a certified
          check, official bank cashier's check or money order in an amount equal
          to the Exercise Price multiplied by the number of shares requested and
          a duly executed copy of this Agreement. At the discretion of the
          Committee, the Grantee may pay all or a portion of the purchase price
          by tender of Common Stock or a combination of stock and cash or other
          means determined by the Committee.

     4.2  Any notice under this Section shall include an undertaking to furnish
          or execute such documents as the Committee in its discretion shall
          deem necessary (i) to evidence such exercise, in whole or in part, of
          the Option evidenced by this Agreement, (ii) to determine whether
          registration is then required under the Securities Act of 1933, or any
          other law, as then in effect, and (iii) to comply with or satisfy the
          requirements of the Securities Act of 1933, or any other law, as then
          in effect.

     4.3  The Grantee agrees that all shares purchased by it under the Option
          will be acquired for investment, not distribution, and that any notice
          of exercise of the Option must be accompanied by a written
          representation to that effect, signed by the Grantee.


                                    SECTION 5
                              TERMINATION OF OPTION

     5.1  The Option granted hereby shall terminate and be of no force or effect
          upon the expiration of ten years from the date of the Grant (i.e.,
          March 13, 2007) unless terminated prior to such time as provided
          below.

     5.2  Subject to Section 3.6 hereof, should the Grantee cease to serve the
          Company, the Grantee's Option shall be exercised as follows:

          (a)  If the Grantee's termination of service is other than for Cause,
          the Option may be exercised, to the extent exercisable, for a period
          of three months after the date of such termination of service;

          (b)  If the Grantee's termination of service is by reason of
          retirement or disability, the Option may be exercised, to the extent
          exercisable, for a period of 12 months after the date of such
          termination of service;

          (c)  In the event of death of Grantee within three months after
          termination of service pursuant to (a) or (b) above, the person or
          persons to whom the Grantee's rights are transferred if at all, by
          will or the laws of descent and distribution shall have a period of
          three years from the date of termination of the Grantee's service to
          exercise the Option which could have been exercised during such
          period; and

          (d)  In the event of death of Grantee while Grantee is providing
          services to the Company under the Consulting Agreement, the Option
          shall become fully and immediately exercisable and may be exercised by
          the person or persons to whom the Grantee's rights are transferred if
          at all, by will or the laws of descent and distribution for a period
          of three years after the Grantee's death, subject to exercise during
          the remaining term of the Option;

                                       3
<PAGE>   4
     5.3  Any determination made by the Committee with respect to any matter
          referred to in this Section 5 shall be final and conclusive on all
          persons affected thereby. Service to the Company shall be deemed to
          include service to any subsidiary of the Company by the Grantee.


                                    SECTION 6
                              ADJUSTMENTS TO OPTION

     6.1  Subject to any required action by the Committee and shareholders, the
          number of shares provided for in the Option, and the price per share
          thereof shall be proportionately adjusted for any increase or decrease
          in the number of issued shares of the Company resulting from the
          payment of a share dividend, a share split or any transaction which is
          a "corporate transaction" (as defined in the Treasury regulations
          promulgated under Section 424 of the Code.

     6.2  Subject to any required action by the Committee and shareholders, if
          the Company shall be the surviving entity in any merger or
          consolidation, or after a consolidation of the Company and one or more
          entities in which the resulting entity is an independent entity, the
          Option shall pertain to and apply to the securities of the surviving
          entity in an amount that the board of directors of the surviving
          entity, at its sole discretion, determines to be equivalent, as nearly
          as practicable, to the nearest whole number and class of shares that
          were subject to the Option. These shares of stock or other securities
          shall, after such merger or consolidation, be deemed to be shares for
          all purposes of this Agreement. The aforesaid adjustments, when
          applicable, shall be made by the Committee, and the Committee's
          determination shall be final, binding and conclusive.

     6.3  In the event of a Change of Control (as defined below), any and all
          outstanding Options not fully vested shall automatically vest in full
          and shall be immediately exercisable. The date on which such
          accelerated vesting and immediate exercisability shall occur shall be
          the date of the occurrence of the Change of Control.

          A "Change of Control" shall be deemed to have taken place upon (i) the
          acquisition by a third person, including a "group" as defined in
          Section 13(d)(3) of the Securities Exchange Act of 1934, as amended,
          of shares of the Company having 50% or more of the total number of
          votes that may be cast for the election of Directors of the Company;
          (ii) shareholder approval of a transaction for the acquisition of the
          Company, or substantially all of its assets by another entity or for a
          merger, reorganization, consolidation or other business combination to
          which the Company is a part; or (iii) the election during any period
          of 24 months or less of 50% or more of the Directors of the Company
          where such Directors were not in office immediately prior to such
          period provided, however, that no "Change of Control" shall be deemed
          to have taken place if the Directors of the Company in office on the
          date of adoption of the Plan, or their successors in office nominated
          by such Directors, affirmatively approve a resolution to such effect.

                                       4
<PAGE>   5
          Except as provided with respect to a Grantee in its stock option
          agreement or other controlling agreement between it and the Company,
          to the extent that the acceleration, exercisability or parachute
          payment attributable to the Option following a Change of Control would
          result in "excess parachute payments"1 when the former are aggregated
          with other payments or benefits to the Grantee, such parachute
          payments or benefits provided to a Grantee under this Agreement shall
          be reduced to the extent necessary so that no portion thereof shall be
          subject to the excise tax imposed by Section 4999 of the Code. This
          reduction will only be made if it will cause the Grantee's net
          after-tax benefit to exceed the net after-tax benefit that would have
          existed if such reduction were not made. "Net after-tax benefit" shall
          be the sum of (i) all payments and benefits which a Grantee receives
          or is entitled to receive that would constitute a "parachute payment"
          under Section 280G of the Code, less (ii) the amount of federal income
          taxes payable with respect to the payments and benefits described in
          (i) above, calculated at the maximum marginal income tax rate2 for the
          year in which such payments and benefits shall be paid to the Grantee,
          less (iii) the amount of excise taxes imposed with respect to the
          payments and benefits described in (i) above by Section 4999 of the
          Code.

     6.4  In the event of a change in the Company's shares which is limited to a
          change of all of its authorized shares with par value into the same
          number of shares with a different par value or without par value, the
          shares resulting from any such change shall be deemed to be shares
          within the meaning of this Agreement.

     6.5  Except as herein before expressly provided in Paragraphs 6.1, 6.2, 6.3
          and 6.4 of this Section 6, the Grantee shall have no rights by reason
          of any subdivision or consolidation of shares of any class or payment
          of any share dividend or any other increase or decrease in the number
          of shares of any class or by reason of any dissolution, liquidation,
          merger, consolidation or spin-off of assets or stock of another
          corporation and any issuance by the Company of shares of any class, or
          securities convertible into shares of any class, shall not affect the
          Option, and no adjustment by reason thereof shall be made with respect
          to the number or price of the Company's shares subject to the Option.
          The grant of the Option shall not affect in any way the right or power
          of the Company to make adjustments, reclassifications, reorganizations
          or changes of its capital or business structure or to merge,
          consolidate, dissolve, liquidate, sell or transfer all or any part of
          its business or assets.


                                    SECTION 7
                                    TRANSFER

     7.1  This Option shall not be transferable by the Grantee in any way other
          than by will and the laws of descent and distribution. During the
          lifetime of the Grantee, the

- -------------
     (1)"Excess parachute payments" are defined in Section 280G of the Code and
are determined by tax counsel of the Company.

     (2) This rate is based on the rate for the year set forth in the Code at
the time of the first payment to the participant.

                                       5
<PAGE>   6
          Option shall be exercisable only by him. Any other attempted
          assignment, transfer, pledge, hypothecation or other disposition of
          the Option shall be void and have no effect unless in accordance with
          the terms set forth herein.


                                    SECTION 8
                                WITHHOLDING TAXES

     8.1  The Company shall have the right to retain and withhold from any
          payment, under the Option granted, any amount that is to be withheld
          or otherwise deducted and paid with respect to such payment. At its
          discretion, the Company may require the Grantee, if he receives shares
          under a nonqualified stock option grant, to reimburse the Company for
          any taxes that are required to be withheld by the Company, and may
          withhold any distribution in whole or in part until the Company is so
          reimbursed. In lieu thereof, the Company shall have the right to
          withhold from any other cash amounts due (or to become due) to the
          Grantee an amount equal to such taxes required to be withheld by the
          Company to reimburse the Company for any such taxes, or the Company
          may retain and withhold a number of shares of Common Stock having a
          market value not less than the amount of such taxes and cancel (in
          whole or in part) any shares of Common Stock so withheld in order to
          reimburse the Company for any such taxes.


                                    SECTION 9
                            IMPACT ON OTHER BENEFITS

     9.1  The value of the Option (either on the date of grant of the Option or
          at the time the shares are vested) shall not be includable as
          compensation or earnings for purposes of any other benefit plan
          offered by the Company.


                                   SECTION 10
                                 ADMINISTRATION

     10.1 The Committee shall have full authority and discretion to decide all
          matters relating to the administration and interpretation of this
          Agreement. All such Committee determinations shall be final,
          conclusive and binding upon the Company, the Grantee and any and all
          interested parties.


                                   SECTION 11
                       AGREEMENT TO CONTINUE IN EMPLOYMENT
                           OR SERVICE AS A CONSULTANT

     11.1 Nothing in this Agreement shall confer on a Grantee any right to
          continue in the employ of the Company or in the service of the Company
          as a consultant or interfere in any way with the right of the Company
          to terminate such consulting relationship at any time.

                                       6
<PAGE>   7
                                   SECTION 12
                                  AMENDMENT(S)

     12.1 This Agreement may not in any way be amended or terminated without the
          Grantee's written consent.


                                   SECTION 13
                                FORCE AND EFFECT

     13.1 The various provisions of this Agreement are severable in their
          entirety. Any determination of invalidity or unenforceability of any
          one provision shall have no effect on the continuing force and effect
          of the remaining provisions.


                                   SECTION 14
                         NOTICE OF DISPOSITION OF SHARES

     14.1 The Grantee agrees that if he should dispose of any shares of Common
          Stock acquired on the exercise of the Option, including a disposition
          by sale, exchange, gift or transfer of legal title within twelve (12)
          months of the date such shares are transferred to the Grantee, the
          Grantee will notify the Company promptly of such disposition.


                                   SECTION 15
                                     NOTICES

     15.1 All notices which may be or are required to be given by one party to
          the other party pursuant to this Agreement shall be in writing and
          shall be mailed by first class or certified mail, return receipt
          requested, postage prepaid, or transmitted by hand delivery as
          follows:

          If to the Company:  DUSA Pharmaceuticals, Inc.
                              181 University Avenue
                              Suite 1208
                              Toronto, ON M5H 3M7
                              CANADA

                              Attention: Dr. D. Geoffrey Shulman

          If to the Grantee:  Daniel Piacquadio
                              c/o Therapeutics, Inc.
                              4180 La Jolla Village Drive, Suite 210
                              La Jolla, California 92037

          or such other address as to which either party may from time to time
          notify the other as aforesaid.

                                       7
<PAGE>   8
                                   SECTION 16
                            RESTRICTIONS ON TRANSFER

     16.1 The Grantee understands and acknowledges that he is subject to certain
          restrictions on transfer under the Securities Act of 1933 of the
          United States, as amended, (the "1933 Act") of the shares issued
          pursuant to the exercise of the Option; such restrictions provide that
          the shares may not be sold without registration or exemption from
          registration under the 1933 Act.


                                   SECTION 17
                                  GOVERNING LAW

     17.1 This Agreement shall be construed and enforced in accordance with and
          governed by the laws of the State of New Jersey.


     IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
hereto.

Attest:                                 DUSA PHARMACEUTICALS, INC.,
                                        a New Jersey corporation

s/ Nanette W. Mantell                   By: s/D. Geoffrey Shulman
- ------------------------------              --------------------------
Nanette W. Mantell, Secretary               Dr. D. Geoffrey Shulman, President

                                        GRANTEE

                                        s/Daniel Piacquadio
                                        ------------------------------
                                        Daniel Piacquadio

                                       8
<PAGE>   9
                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:  The Secretary of DUSA Pharmaceuticals, Inc.

     Pursuant to the terms and subject to the conditions set forth in the
Nonqualified Stock Option Agreement (the "Agreement") dated MARCH 13, 1997
between DUSA Pharmaceuticals, Inc. and the undersigned, and the Option granted
to the undersigned by such Agreement, I hereby elect to purchase _______________
shares of Common Stock of DUSA Pharmaceuticals, Inc. which were the subject of
such Option. I understand that such purchase is subject to all the terms and
conditions of the Agreement. I request that the certificates for such shares of
Common Stock shall be issued in the name of:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:


- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

     The undersigned hereby represents and warrants to, and agrees with the
Company as follows:

     (a) The shares are being purchased for the undersigned's own account, for
investment purposes only, and not for the account of any other person, and not
with a view to distribution, assignment, or resale to others, or to
fractionalization in whole or in part and that the offering and sale of the
shares is intended to be exempt from registration under the Securities Act of
1933 (the "Act"). In furtherance thereof, the undersigned represents, warrants
and agrees as follows: (i) no other person has or will have a direct or indirect
beneficial interest in such shares and the undersigned will not sell,
hypothecate, or otherwise transfer his shares except in accordance with the Act
and applicable state securities laws or unless in the opinion of counsel for the
Company, an exemption from the registration requirements of the Act and such
laws is available; and (ii) the Company is under no obligation to register the
shares on behalf of the undersigned or to assist the undersigned in complying
with any exemption from registration.
<PAGE>   10
     (b) The undersigned has such knowledge and experience in financial and
business matters that the undersigned is capable of evaluating the merits and
risks of investment in the Company and of making an informed investment
decision.

     In full payment of the purchase price with respect to the Option exercised,
the undersigned hereby tenders payment of $___________ by certified check or
official bank cashier's check or money order payable in United States currency
to the order of DUSA Pharmaceuticals, Inc.

Dated:                               X
                                      ------------------------------------------
                                         (Signature)

                                         ---------------------------------------
                                         Name (Please Print)

                                         ---------------------------------------
                                         (Address)

                                         ---------------------------------------
                                         Taxpayer Identification Number

<PAGE>   1
                                                                    Exhibit 4.17

                             STOCK OPTION AGREEMENT

     THIS AGREEMENT is made as of the 14 day of April, 1994 between DUSA
PHARMACEUTICALS, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and ALLYN L. GOLUB, PHD,
c/o Guidelines, Inc., 18441 NW 2nd Avenue, Miami, Florida, (hereinafter referred
to as the "Participants").

     WITNESSETH:

     WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant an option to him to
purchase shares of the Company's common stock ("Shares") on the terms and
conditions set forth in this Agreement.

     NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:

1.1  DEFINITIONS

     In this Agreement:

     "Board of Directors" means the board of directors of the Company;

     "Exercise Price" means U.S. $3.625;

     "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later of
     the dates provided in Section 2.2;

     "Optioned Shares" means that number of Shares which are subject to the
     option granted by the Company to the Participants pursuant to this
     Agreement;

     "Services" means consulting or other services provided by the Participants
     to the Company pursuant to the Consulting Agreement between the
     Participants and the Company; and

     "Shares" means shares of common stock, without par value, of the Company.
<PAGE>   2
2.1  GRANT OF OPTION

     The Company hereby grants to the Participant an option to purchase, in
     accordance with the vesting rights outlined in Sections 2.6 and 2.7 hereof,
     up to 10,000 Shares, for an amount per Share equal to the Exercise Price,
     upon the terms and subject to the conditions herein contained.

2.2  Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have the
     right, at any time prior to 5:00 p.m. (Eastern Standard Time) on the fifth
     anniversary date hereof, being April 14, 1999 (provided that if such day is
     not a day on which the Company is open for business then on the first
     following day on which the Company is open for business) to exercise this
     option for any number of the Optioned Shares up to the maximum number of
     Shares specified in Section 2.1 above.

2.3  The option may be exercised by the Participant or by his executors or
     personal representatives in the circumstances described in Section 4.1 by
     providing to the Company notice in writing in the form of Schedule A hereto
     setting out the number of Optioned Shares with respect to which the option
     is being exercised. The notice must be accompanied by a certified check,
     official bank cashier's check or money order in an amount equal to the
     Exercise Price multiplied by the number of Shares requested and a duly
     executed copy of this Agreement.

2.4  The Company shall cause its registrar and transfer agent to deliver to the
     Participant as soon as practicable after receipt of such notice and payment
     a certificate or certificates registered in the name of the Participant or
     as the Participant may direct for the number of Shares with respect to
     which the option is duly exercised.

2.5  Nothing contained in this Agreement or action taken pursuant hereto shall
     obligate the Participant to purchase and/or pay for, or the Company to
     issue, any Shares except those Optioned Shares with respect to which the
     Participant shall have duly exercised the option to purchase in accordance
     with this Agreement.

2.6  Subject to Section 2.7 hereof, the option granted hereunder shall vest in
     the following manner:

     (a)  one-quarter of the option on the first anniversary of the day
          immediately preceding the date hereof, being April 13, 1995;

     (b)  one-quarter of the option on the second anniversary of the day
          immediately preceding the date hereof, being April 13, 1996;

     (c)  one-quarter of the option on the third anniversary of the day
          immediately preceding the date hereof, being April 13, 1997; and

     (d)  one-quarter of the option on the fourth anniversary of the day
          immediately preceding the date hereof, being April 13, 1998;

                                       2
<PAGE>   3
     and, except as provided by Section 6.1, the Participant shall only be
     entitled to exercise this option in the amounts set out above and from and
     after the dates so specified.

2.7  Notwithstanding anything contained in Section 2.6 hereof, the option shall
     continue to vest only so long as the Participant continues to provide
     Services to the Company. Should the Participant ceases to provide such
     Services ("Termination"), no further vesting of the option shall occur
     unless the Board of Directors determines otherwise and the provisions of
     Section 3.1 shall apply with respect to the exercise of the option to the
     extent that it has vested and has not yet been exercised.

3.1  EXPIRATION ON TERMINATION

     Subject to Section 4.1 hereof, upon Termination, such part of the option as
     is then vested but unexercised may be exercised by the Participant for a
     period of ninety (90) days after Termination or such later date as the
     Board of Directors may approve after which time this option shall expire;
     provided, however, that in no event may this option be exercised after the
     Expiration Date.

4.1  DEATH OR PERMANENT DISABILITY

     In the event that on or prior to the Expiration Date, the Participant dies
     or becomes totally and permanently disabled while providing Services to the
     Company, this option, to the extent then vested but unexercised, may be
     exercised by the Participant for a period up to six (6) months after the
     death or disability of the Participant; provided, however, that in no event
     may this option be exercised after the Expiration Date. Disability shall be
     defined as in Section 22(e)(3) of the Internal Revenue Code of 1986, as
     amended. For the purposes of this provision only, reference to the
     Participant in this Agreement shall be construed as including the executors
     or personal representatives of a deceased Participant. In the event that
     this option is not exercised within the period of six (6) months set out
     above, this option shall expire.

5.1  SUBDIVISION, CONSOLIDATION OR REORGANIZATION

     (a)  In the event of any subdivision, redivision or change of the Shares of
     the Company into a greater number of Shares at any time after the date of
     this Agreement and prior to the Expiration Date of this option, the Company
     shall deliver at the time of exercise of this option, but for the same
     aggregate consideration payable therefor, such additional number of Shares
     as the Participant would have been entitled to receive as a result of such
     subdivision, redivision or change if on the record date thereof the
     Participant had been the registered holder of the number of such Shares
     with respect to which the option is later exercised.

     (b)  In the event of any consolidation or change of the Shares of the
     Company into a lesser number of Shares at any time after the date of this
     Agreement and prior to the expiration of this option, the Company shall
     deliver at the time of exercise of this option, but for the same aggregate
     consideration payable therefor, such reduced number of Shares, as the
     Participant would have been entitled to receive upon such consolidation or
     change if on

                                       3
<PAGE>   4
     the record date thereof the Participant had been the registered holder of
     the number of such Shares with respect to which the option is later
     exercised.

     (c)  If at any time after the date of this Agreement and prior to the
     expiration of this option, the Shares shall be reclassified or reorganized,
     otherwise than as specified in Sections 5.1(a) and (b), the Participant
     shall be entitled to receive upon the exercise of this option and shall
     accept in lieu of the number of Shares then subscribed for, but for the
     same aggregate consideration payable therefor, the same aggregate number of
     shares of the appropriate class of shares that the Participant would have
     been entitled to receive as a result of such reclassification or other
     reorganization of Shares if on the record date thereof the Participant had
     been the registered holder of the number of such Shares with respect to
     which the option is later exercised.

6.1  TAKE-OVER BID

     If an offeror makes an offer to purchase 50% or more of the outstanding
     Shares to substantially all holders of the Shares or, if an insider of the
     Company makes an offer to purchase Shares to substantially all holders of
     the Shares, and the Board of Directors recommends acceptance of such offer
     to the shareholders of the Company and the offer price is greater than the
     Exercise Price, then this option, whether or not it has vested in whole or
     in part, shall become immediately exercisable. The Participant shall be
     bound to exercise this option and to tender the Optioned Shares issued upon
     exercise of this option into the offer upon receipt of notice from the
     Company if the Company provides an interest-free loan to the Participant in
     the amount of the Exercise Price for all of the Optioned Shares issuable
     upon exercise of this option, subject to the execution of a security
     agreement by the Participant in favor of the Company securing repayment of
     the loan.

7.1  NO ASSIGNMENT

     The Participant may not assign, transfer, pledge or hypothecate any of his
     rights hereunder in any way (whether by operation of law or otherwise)
     except by will or by the laws of succession on intestacy which may apply to
     the estate of the Participant upon his death. The option granted herein
     shall not be subject to execution, attachment or similar process. Upon any
     attempt to assign, transfer, pledge, hypothecate or otherwise dispose of
     this option contrary to the provisions hereof, or upon the levy of any
     attachment or similar process upon the option granted herein, such option
     shall immediately become void.

8.1  GENERAL

     (a)  Time shall be of the essence of this Agreement.

     (b)  In this Agreement, words importing the singular number include the
     plural and vice versa and words importing the masculine gender include the
     feminine and neuter genders.

     (c)  All notices which may be or are required to be given by one party to
     the other party pursuant to this Agreement shall be in writing and shall be
     mailed by first class or certified mail, return receipt requested, postage
     prepaid, or transmitted by hand delivery as follows:

                                       4
<PAGE>   5
     If to the Company:           DUSA Pharmaceuticals, Inc.
                                  6870 Goreway Drive
                                  Mississauga, ON L4V 1P1

                                  Attention:  Dr. D. Geoffrey Shulman

                 with a copy to:  Nanette W. Mantell, Esq., Corporate Secretary
                                  Lane and Mantell
                                  991 Route 22 West
                                  PO Box 8539
                                  Somerville, NJ 08876
                                  U.S.A.

     If to the Participant:       at the address of the Participant from
                                  time to time in the records of the
                                  Company,

     or such other address as to which either party may from time to time notify
     the other as aforesaid.

9.1  RESTRICTIONS ON TRANSFER

     The Participant understands and acknowledges that the option and Shares
     underlying the option have not been registered and that they are subject to
     certain restrictions on transfer under the Securities Act of 1933 of the
     United States, as amended, (the "1933 Act"); such restrictions provide that
     the Shares may not be sold without registration or exemption from
     registration under the 1933 Act; and, for purposes of the Securities Act
     (Ontario) (the "Ontario Act"), the first trade of the Shares issued
     pursuant to the exercise of the option, other than a trade exempted by the
     Ontario Act, will be a distribution unless the Company has been a reporting
     issuer for at least twelve (12) months and the Company is not in default of
     any requirement of the Ontario Act, disclosure has been made to the Ontario
     Securities Commission of the exempt trade, no unusual effort is made to
     prepare the market or create a demand for the Shares, and no extraordinary
     commission or consideration is paid with respect to the trade, provided
     that such first trade is not from the holdings of a so-called "control
     block".

                                       5
<PAGE>   6
     IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
hereto.

Attest:                                 DUSA PHARMACEUTICALS, INC.
                                        a New Jersey corporation

s/ Edward L. Foster                     By: s/D. Geoffrey Shulman
- ---------------------------                 ------------------------------------
Edward L. Foster, Treasurer                 Dr. D. Geoffrey Shulman, President


Witness:                                PARTICIPANT


s/Caren R. Bezach                       s/Allyn L. Golub
- ---------------------------               --------------------------------------
                                                                  ALLYN L. GOLUB

                                       6
<PAGE>   7
                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:  The Secretary of DUSA Pharmaceuticals, Inc.

     Pursuant to the terms and subject to the conditions set forth in the Stock
Option Agreement (the "Agreement") dated         , between DUSA Pharmaceuticals,
Inc. and the undersigned, I hereby elect to purchase      shares of Common Stock
of DUSA Pharmaceuticals, Inc. I understand that such purchase is subject to all
the terms and conditions of the Agreement. I request that the certificates for
such shares of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)


and be delivered to:


- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

     In full payment of the purchase price with respect to the Optioned Shares
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian
currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                                  X
                                         -------------------------------------
                                             (Signature)

                                             ---------------------------------
                                             Name (Please Print)

                                             ---------------------------------
                                             (Address)

                                             ---------------------------------
                                             Taxpayer Identification Number

<PAGE>   1
                                                                    Exhibit 4.18

                             STOCK OPTION AGREEMENT

     THIS AGREEMENT is made as of the 14 day of April, 1994 between DUSA
PHARMACEUTICALS, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and DAVID M. COHEN, PHD,
c/o Guidelines, Inc., 18441 NW 2nd Avenue, Miami, Florida, (hereinafter referred
to as the "Participants").

     WITNESSETH:

     WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant an option to him to
purchase shares of the Company's common stock ("Shares") on the terms and
conditions set forth in this Agreement.

     NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:

1.1  DEFINITIONS

     In this Agreement:

     "Board of Directors" means the board of directors of the Company;

     "Exercise Price" means U.S. $3.625;

     "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later of
     the dates provided in Section 2.2;

     "Optioned Shares" means that number of Shares which are subject to the
     option granted by the Company to the Participants pursuant to this
     Agreement;

     "Services" means consulting or other services provided by the Participants
     to the Company pursuant to the Consulting Agreement between the
     Participants and the Company; and

     "Shares" means shares of common stock, without par value, of the Company.
<PAGE>   2
2.1  GRANT OF OPTION

     The Company hereby grants to the Participant an option to purchase, in
     accordance with the vesting rights outlined in Sections 2.6 and 2.7 hereof,
     up to 10,000 Shares, for an amount per Share equal to the Exercise Price,
     upon the terms and subject to the conditions herein contained.

2.2  Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have the
     right, at any time prior to 5:00 p.m. (Eastern Standard Time) on the fifth
     anniversary date hereof, being April 14, 1999 (provided that if such day is
     not a day on which the Company is open for business then on the first
     following day on which the Company is open for business) to exercise this
     option for any number of the Optioned Shares up to the maximum number of
     Shares specified in Section 2.1 above.

2.3  The option may be exercised by the Participant or by his executors or
     personal representatives in the circumstances described in Section 4.1 by
     providing to the Company notice in writing in the form of Schedule A hereto
     setting out the number of Optioned Shares with respect to which the option
     is being exercised. The notice must be accompanied by a certified check,
     official bank cashier's check or money order in an amount equal to the
     Exercise Price multiplied by the number of Shares requested and a duly
     executed copy of this Agreement.

2.4  The Company shall cause its registrar and transfer agent to deliver to the
     Participant as soon as practicable after receipt of such notice and payment
     a certificate or certificates registered in the name of the Participant or
     as the Participant may direct for the number of Shares with respect to
     which the option is duly exercised.

2.5  Nothing contained in this Agreement or action taken pursuant hereto shall
     obligate the Participant to purchase and/or pay for, or the Company to
     issue, any Shares except those Optioned Shares with respect to which the
     Participant shall have duly exercised the option to purchase in accordance
     with this Agreement.

2.6  Subject to Section 2.7 hereof, the option granted hereunder shall vest in
     the following manner:

     (a)  one-quarter of the option on the first anniversary of the day
          immediately preceding the date hereof, being April 13, 1995;

     (b)  one-quarter of the option on the second anniversary of the day
          immediately preceding the date hereof, being April 13, 1996;

     (c)  one-quarter of the option on the third anniversary of the day
          immediately preceding the date hereof, being April 13, 1997; and

     (d)  one-quarter of the option on the fourth anniversary of the day
          immediately preceding the date hereof, being April 13, 1998;
<PAGE>   3
     and, except as provided by Section 6.1, the Participant shall only be
     entitled to exercise this option in the amounts set out above and from and
     after the dates so specified.

2.7  Notwithstanding anything contained in Section 2.6 hereof, the option shall
     continue to vest only so long as the Participant continues to provide
     Services to the Company. Should the Participant ceases to provide such
     Services ("Termination"), no further vesting of the option shall occur
     unless the Board of Directors determines otherwise and the provisions of
     Section 3.1 shall apply with respect to the exercise of the option to the
     extent that it has vested and has not yet been exercised.

3.1  EXPIRATION ON TERMINATION

     Subject to Section 4.1 hereof, upon Termination, such part of the option as
     is then vested but unexercised may be exercised by the Participant for a
     period of ninety (90) days after Termination or such later date as the
     Board of Directors may approve after which time this option shall expire;
     provided, however, that in no event may this option be exercised after the
     Expiration Date.

4.1  DEATH OR PERMANENT DISABILITY

     In the event that on or prior to the Expiration Date, the Participant dies
     or becomes totally and permanently disabled while providing Services to the
     Company, this option, to the extent then vested but unexercised, may be
     exercised by the Participant for a period up to six (6) months after the
     death or disability of the Participant; provided, however, that in no event
     may this option be exercised after the Expiration Date. Disability shall be
     defined as in Section 22(e)(3) of the Internal Revenue Code of 1986, as
     amended. For the purposes of this provision only, reference to the
     Participant in this Agreement shall be construed as including the executors
     or personal representatives of a deceased Participant. In the event that
     this option is not exercised within the period of six (6) months set out
     above, this option shall expire.

5.1  SUBDIVISION, CONSOLIDATION OR REORGANIZATION

     (a)  In the event of any subdivision, redivision or change of the Shares of
     the Company into a greater number of Shares at any time after the date of
     this Agreement and prior to the Expiration Date of this option, the Company
     shall deliver at the time of exercise of this option, but for the same
     aggregate consideration payable therefor, such additional number of Shares
     as the Participant would have been entitled to receive as a result of such
     subdivision, redivision or change if on the record date thereof the
     Participant had been the registered holder of the number of such Shares
     with respect to which the option is later exercised.

     (b)  In the event of any consolidation or change of the Shares of the
     Company into a lesser number of Shares at any time after the date of this
     Agreement and prior to the expiration of this option, the Company shall
     deliver at the time of exercise of this option, but for the same aggregate
     consideration payable therefor, such reduced number of Shares, as
<PAGE>   4
     the Participant would have been entitled to receive upon such consolidation
     or change if on the record date thereof the Participant had been the
     registered holder of the number of such Shares with respect to which the
     option is later exercised.

     (c)  If at any time after the date of this Agreement and prior to the
     expiration of this option, the Shares shall be reclassified or reorganized,
     otherwise than as specified in Sections 5.1(a) and (b), the Participant
     shall be entitled to receive upon the exercise of this option and shall
     accept in lieu of the number of Shares then subscribed for, but for the
     same aggregate consideration payable therefor, the same aggregate number of
     shares of the appropriate class of shares that the Participant would have
     been entitled to receive as a result of such reclassification or other
     reorganization of Shares if on the record date thereof the Participant had
     been the registered holder of the number of such Shares with respect to
     which the option is later exercised.

6.1  TAKE-OVER BID

     If an offeror makes an offer to purchase 50% or more of the outstanding
     Shares to substantially all holders of the Shares or, if an insider of the
     Company makes an offer to purchase Shares to substantially all holders of
     the Shares, and the Board of Directors recommends acceptance of such offer
     to the shareholders of the Company and the offer price is greater than the
     Exercise Price, then this option, whether or not it has vested in whole or
     in part, shall become immediately exercisable. The Participant shall be
     bound to exercise this option and to tender the Optioned Shares issued upon
     exercise of this option into the offer upon receipt of notice from the
     Company if the Company provides an interest-free loan to the Participant in
     the amount of the Exercise Price for all of the Optioned Shares issuable
     upon exercise of this option, subject to the execution of a security
     agreement by the Participant in favor of the Company securing repayment of
     the loan.

7.1  NO ASSIGNMENT

     The Participant may not assign, transfer, pledge or hypothecate any of his
     rights hereunder in any way (whether by operation of law or otherwise)
     except by will or by the laws of succession on intestacy which may apply to
     the estate of the Participant upon his death. The option granted herein
     shall not be subject to execution, attachment or similar process. Upon any
     attempt to assign, transfer, pledge, hypothecate or otherwise dispose of
     this option contrary to the provisions hereof, or upon the levy of any
     attachment or similar process upon the option granted herein, such option
     shall immediately become void.

8.1  GENERAL

     (a)  Time shall be of the essence of this Agreement.

     (b)  In this Agreement, words importing the singular number include the
     plural and vice versa and words importing the masculine gender include the
     feminine and neuter genders.

     (c)  All notices which may be or are required to be given by one party
     to the other party
<PAGE>   5
     pursuant to this Agreement shall be in writing and shall be mailed by first
     class or certified mail, return receipt requested, postage prepaid, or
     transmitted by hand delivery as follows:



     If to the Company:           DUSA Pharmaceuticals, Inc.
                                  6870 Goreway Drive
                                  Mississauga, ON L4V 1P1

                                  Attention:  Dr. D. Geoffrey Shulman

                 with a copy to:  Nanette W. Mantell, Esq., Corporate Secretary
                                  Lane and Mantell
                                  991 Route 22 West
                                  PO Box 8539
                                  Somerville, NJ 08876
                                  U.S.A.

     If to the Participant:       at the address of the Participant from
                                  time to time in the records of the
                                  Company,

     or such other address as to which either party may from time to time notify
     the other as aforesaid.

9.1  RESTRICTIONS ON TRANSFER

     The Participant understands and acknowledges that the option and Shares
     underlying the option have not been registered and that they are subject to
     certain restrictions on transfer under the Securities Act of 1933 of the
     United States, as amended, (the "1933 Act"); such restrictions provide that
     the Shares may not be sold without registration or exemption from
     registration under the 1933 Act; and, for purposes of the Securities Act
     (Ontario) (the "Ontario Act"), the first trade of the Shares issued
     pursuant to the exercise of the option, other than a trade exempted by the
     Ontario Act, will be a distribution unless the Company has been a reporting
     issuer for at least twelve (12) months and the Company is not in default of
     any requirement of the Ontario Act, disclosure has been made to the Ontario
     Securities Commission of the exempt trade, no unusual effort is made to
     prepare the market or create a demand for the Shares, and no extraordinary
     commission or consideration is paid with respect to the trade, provided
     that such first trade is not from the holdings of a so-called "control
     block".
<PAGE>   6
     IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
hereto.

Attest:                               DUSA PHARMACEUTICALS, INC.
                                      a New Jersey corporation

s/ Edward L. Foster                   By: s/D. Geoffrey Shulman
- -------------------------------           -------------------------------
Edward L. Foster, Treasurer               Dr. D. Geoffrey Shulman, President

Witness:                              PARTICIPANT

                                      s/David M. Cohen
- -------------------------------       -----------------------------------
                                                                  DAVID M. COHEN
<PAGE>   7
                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:  The Secretary of DUSA Pharmaceuticals, Inc.

     Pursuant to the terms and subject to the conditions set forth in the Stock
Option Agreement (the "Agreement") dated        , between DUSA Pharmaceuticals,
Inc. and the undersigned, I hereby elect to purchase           shares of Common
Stock of DUSA Pharmaceuticals, Inc. I understand that such purchase is subject
to all the terms and conditions of the Agreement. I request that the
certificates for such shares of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

     In full payment of the purchase price with respect to the Optioned Shares
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian
currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                          X
                                 -------------------------------------
                                            (Signature)

                                           -------------------------------------
                                            Name (Please Print)

                                           -------------------------------------
                                            (Address)

                                           -------------------------------------
                                            Taxpayer Identification Number

<PAGE>   1
                                                                    Exhibit 4.19

                               DEPRENYL USA, INC.
                            a New Jersey corporation
                        NON-TRANSFERABLE CLASS B WARRANT

<TABLE>
   Class B
   Warrant                                                   Number of
Certificate No.                                              Warrants
- ---------------                                              --------
<S>                                                         <C>
       1                                                     350,000

</TABLE>

THIS CERTIFIES THAT, for value received

          D. GEOFFREY SHULMAN, MD, FRCPC

or registered assigns (the "Registered Holder") is the owner of the number of
Non-transferable Class B Warrants (the "Class B Warrants") specified above. Each
Class B Warrant initially entitles the Registered Holder to purchase subject to
the terms and conditions set forth in this Class B Warrant Certificate (the
"Certificate) one (1) fully paid and non-assessable share of Common Stock, no
par value, of Deprenyl USA, Inc., a New Jersey corporation (the "Company"), at
any time prior to the Expiration Date (as hereinafter defined) upon the
presentation and surrender of the Certificate with the Subscription Form
attached hereto duly executed at the corporate offices of the Company, 378
Roncesvalles Avenue, Toronto, Ontario M6R 2M7, CANADA, accompanied by payment of
the Canadian dollar equivalent on the date of issue of this Certificate of U.S.
$6.00 per share of Common Stock based on the Bank of Canada's noon rate of
exchange on such date (the "Class B Warrant Exercise Price") in lawful money of
Canada in cash or by official bank or certified check made payable to the
Company. The Company may, at its election, reduce the purchase price, subject to
any applicable regulatory requirements.

     This Certificate and each Class B Warrant represented hereby are issued
pursuant to and are subject in all respects to the terms and conditions set
forth herein.

     These Class B Warrants are non-transferable and will not be listed or
included for trading by the Company on any stock exchange or other organized
market for securities.

     In the event of a merger, consolidation, reclassification,
recapitalization, or other similar transaction, the Class B Exercise Price or
the number of shares of Common Stock subject to purchase upon the exercise of
each Class B Warrant represented hereby are subject to modification or
adjustment, as set forth in the agreement dated January 17, 1992 between the
Company and its warrant agent, American Stock Transfer and Trust Company (the
"Warrant Agreement"),

     The Class B Warrants represented hereby are exercisable at the option of
the Registered Holder, but no fractional shares of Common Stock will be issued
and the Registered Holder understands and agrees that such holder will not be
entitled to any cash payment or other form of compensation in respect of a
fractional share of Common Stock that might otherwise have been
<PAGE>   2
issued. In the case of the exercise of less than all the Class B Warrants
represented hereby, the Company shall cancel this Certificate upon the surrender
hereof and shall execute and deliver a new Class B Warrant Certificate or Class
B Warrant Certificates of like tenor for the balance of such Class B Warrants.

     The term "Expiration Date" shall mean 5:00 p.m., Eastern Standard Time, on
January 29, 1997. If such date shall in the State of New York or the Province of
Ontario be a holiday or a day on which the banks are authorized to close, then
the Expiration Date shall mean 5:00 p.m., Eastern Standard Time, the next
following day which in the State of New York and the Province of Ontario is not
a holiday or a day on which the banks are authorized to close. The Company may
at its election extend the Expiration Date, subject to any applicable regulatory
requirements.

     The Company shall not be obligated to deliver any securities pursuant to
the exercise of any Class B Warrants represented hereby in the United States
unless a registration statement under the Securities Act of 1933, as amended,
with respect to such securities is effective. The Company has consented and
agreed that it will use its reasonable best efforts to file a registration
statement and to cause the same to become effective and to keep such
registration statement current while any of the Class B Warrants are
outstanding. Any Class B Warrant represented hereby shall not be exercisable by
a Registered Holder in any state of the United States or province of Canada
where such exercise would be unlawful.

     Prior to the exercise of any Class B Warrant represented hereby, the
Registered Holder shall not be entitled to any rights as a shareholder of the
Company, including, without limitation, the right to vote or to receive
dividends or other distributions and shall not be entitled to receive any notice
of any proceedings of the Company except as provided by the Warrant Agreement.

     Prior to due presentment for registration hereof, the Company may deem and
treat the Registered Holder as the absolute owner hereof and of each Class B
Warrant represented hereby, (notwithstanding any notations of ownership or
writing thereon made by anyone other than a duly authorized officer of the
Company) for all purposes and shall not be affected by any notice to the
contrary.

     This Certificate shall be governed by and construed in accordance with the
laws of the State of New Jersey.

     This Certificate is not valid unless countersigned by the President of the
Company and attested by the Secretary or Assistant Secretary.

     The Company may delegate its duties as warrant agent hereunder to such
other company engaged in the business of corporate stock transfer as the Company
sees fit. The Company will give notice of such delegation to the Registered
Holder at his last known address.
<PAGE>   3
     IN WITNESS WHEREOF, the Company has caused this Certificate to be duly
executed, manually or in facsimile by two of its officers thereunto duly
authorized and a facsimile of its corporate seal to be imprinted hereon.

                                         DEPRENYL USA, INC.

                                         By: s/D. Geoffrey Shulman
                                             -----------------------------------
                                             D. Geoffrey Shulman, President

                                         By: s/Edward L. Foster
                                            ------------------------------------
                                             Edward L. Foster, Secretary
<PAGE>   4
                                SUBSCRIPTION FORM

                     To Be Executed by the Registered Holder
                      in Order to Exercise Class B Warrants

     The undersigned Registered Holder hereby irrevocably elects to exercise,
upon the terms and subject to the conditions set forth herein and in the Warrant
Agreement dated *, 1992, Class B Warrants represented by this Class B Warrant
Certificate and to purchase the securities issuable upon the exercise of such
Class B Warrants, and requests that certificates for such securities shall be
issued in the name of

           (PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER)

- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to

- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------
                     (please print or type name and address)

and if such number of Class B Warrants shall not be all the Class B Warrants
evidenced by this Class B Warrant Certificate, that a new Class B Warrant
Certificate for the issuance of such Class B Warrants be registered in the name
of, and delivered to, the Registered Holder at the address stated below.
<PAGE>   5
     In full payment of the Purchase Price with respect to the Class B Warrants
exercised, the undersigned hereby tenders payment of $__________ in cash or by
official bank or certified check, payable in United States currency to the order
of Deprenyl USA, Inc., and undertakes to provide to the Warrant Agent any
additional tax or charge within five (5) business days hereof.

Dated:                                      X
      ------------------------               -----------------------------------
                                                (Signature)

Certificate Nos:
                                             -----------------------------------
                                                (Name - Please Print)


- -----------------------------------          -----------------------------------
Number of Warrants                           (Address)


- -----------------------------------          -----------------------------------
                                               Taxpayer Identification Number


                                                  ------------------------------
                                                        Signature Guaranteed


                                                  ------------------------------



<PAGE>   6
                                   ASSIGNMENT

                     To Be Executed by the Registered Holder
                       in order to Assign Class B Warrants

 FOR VALUE RECEIVED,___________________hereby sells, assigns, and transfers unto


           (PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER)


- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------
                     (please print or type name and address)


________________________of the Class B Warrants represented by this Class B
Warrant Certificate, and hereby irrevocably constitutes and appoints

- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------

Attorney to transfer this Class B Warrant Certificate on the books of the
Company, with full power of substitution in the premises.

Dated:                                           X
      ------------------------                    ------------------------------
                                                     (Signature)


Certificate Nos:                                  ------------------------------
                                                     (Name - Please Print)

- ------------------------------

Number of Warrants                                ------------------------------
                                                     (Address)

- ------------------------------                    ------------------------------
                                                  Taxpayer Identification Number


                                                  ------------------------------
                                                            Signature Guaranteed


                                                  ------------------------------

THE SIGNATURE TO THIS ASSIGNMENT OR THE SUBSCRIPTION FORM MUST CORRESPOND TO THE
NAME AS WRITTEN UPON THE FACE OF THIS CLASS B

<PAGE>   7

WARRANT CERTIFICATE IN EVERY PARTICULAR, WITHOUT ALTERATION OR ENLARGEMENT OR
ANY CHANGE WHATSOEVER, AND MUST BE GUARANTEED BY A COMMERCIAL BANK OR TRUST
COMPANY OR A MEMBER FIRM OF THE AMERICAN STOCK EXCHANGE, NEW YORK STOCK
EXCHANGE, PACIFIC STOCK EXCHANGE, MIDWEST STOCK EXCHANGE, OR TORONTO STOCK
EXCHANGE.

<PAGE>   1
                                LANE AND MANTELL                    Exhibits 5.1
                           a professional corporation                   and 23.2
                                ATTORNEYS AT LAW

               991 Route 22 West, Post Office Box 8539, Suite 102
                          Somerville, New Jersey 08876

Nanette Weitman Mantell                                 Telephone (908) 253-9333
Steven R. Lane                                          Facsimile (908) 253-9339

  ------------
Rosemary Farr                                                     Howard Freeman
                                                                      Of Counsel

                                December 7, 1999

DUSA Pharmaceuticals, Inc.
25 Upton Drive
Wilmington, Massachusetts 02061

Re:  DUSA Pharmaceuticals, Inc. (the "Company")
     Registration Statement on Form S-8

Gentlemen:

     We have examined the Company's registration statement on Form S-8 (the
"Registration Statement") which is being filed with the Securities and Exchange
Commission (the "SEC") in connection with the registration under the Securities
Act of 1933, as amended (the "Act") of an aggregate of 2,591,855 shares (the
"Optioned Shares") of the Company's common stock, without par value (the "Common
Stock") under the 1991 Incentive Stock Option Plan of Deprenyl USA, Inc., the
DUSA Pharmaceuticals, Inc. 1994 Restricted Stock Option Plan, the DUSA
Pharmaceuticals, Inc. 1996 Omnibus Plan, as amended and pursuant to various
agreements between the Company and individual holders of options or other rights
to acquire the Company's Common Stock (collectively "the Plans").

     This opinion is being furnished in accordance with the requirements of Item
8 of Form S-8 and Item 601(b)(5)(i) of Regulation S-K.

     As legal counsel to the Company, we have examined the proceedings taken and
proposed to be taken in connection with the issuance, sale and payment of
consideration for the Optioned Shares under the Plans. We have also examined the
original or a photostatic or certified copy of (i) the Certificate of
Incorporation of the Company, and all amendments to the Certificate of
Incorporation filed by the Company in the Office of the Secretary of State of
the State of New Jersey; (ii) the By-laws of the Company; and (iii) such records
of corporate proceedings and other documents as we have deemed necessary in
order to enable us to express the opinion set forth below. In our examination,
we have assumed the genuineness of all signatures, the authenticity of all
documents submitted to us as originals and the conformity with the original of
all documents
<PAGE>   2
DUSA Pharmaceuticals, Inc.
December 7, 1999
Page 2



submitted to us as copies thereof. Our opinion set forth below is
limited to the Business Corporation Law of the State of New Jersey.

     Based on the foregoing examination, subject to the assumptions stated and
relying on statements of fact contained in the documents that we have examined,
we are of the opinion that the Optioned Shares have been duly authorized and
reserved for issuance and that when issued and sold in the manner described in
the Plans and pursuant to the agreement which may accompany each grant under the
Plans, the Optioned Shares will be legally and validly issued, fully paid and
non-assessable.

     We hereby consent to the filing of this opinion as an exhibit to the
Registration Statement. We also consent to the reference to our firm's name
wherever appearing in the Registration Statement, including any prospectus
constituting a part thereof, and any amendments thereto. This opinion may be
incorporated by reference in any abbreviated registration statement filed
pursuant to General Instruction E of Form S-8 under the Act with respect to the
Registration Statement.

                                Very truly yours,

                                LANE AND MANTELL
                                a professional corporation

                                /s/Nanette W. Mantell

                                By: NANETTE W. MANTELL

NWM/

<PAGE>   1
                              DELOITTE & TOUCHE LLP                 EXHIBIT 23.1
                                    BCE PLACE
                                 181 BAY STREET
                                   SUITE 1400
                             TORONTO, ONTARIO M5J2V1
                                     CANADA

INDEPENDENT AUDITORS' CONSENT

We consent to the incorporation by reference in this Registration Statement of
Dusa Pharmaceuticals, Inc. on Form S-8 of our report dated February 4, 1999
(which expresses an unqualified opinion and includes an emphasis paragraph
indicating that the Company is in the development stage), appearing in the
Annual Report on Form 10-K of Dusa Pharmaceuticals, Inc. for the year ended
December 31, 1998.

/s/ Deloitte & Touche LLP
Chartered Accountants

Toronto, Ontario
December 7, 1999

<PAGE>   1
                                                                    Exhibit 99.1

                               DEPRENYL USA, INC.

                        INCENTIVE STOCK OPTION AGREEMENT

     DEPRENYL USA, INC., a New Jersey corporation (the "Company") hereby grants
to * ("You") an option (the "Option") to purchase a total of * shares of common
stock of the Company (the "Shares") at a price determined in accordance with the
Company's Incentive Stock Option Plan as adopted on September 26, 1991 (the
"Plan") which is incorporated herein by reference. Unless otherwise defined
herein, the terms shall have the same meanings as in the Plan.

     1.   Nature of the Option. This Option is intended to qualify as an
incentive stock option as such term is defined in Section 422 of the Internal
Revenue Code (the "Code").

     2.   Exercise Price. The exercise price for each Share (the "Option Price")
is *, which is not less than the fair market value per Share on the date of
grant (i.e.,*).

     3.   Exercise of Option. This Option shall be exercisable during its term
in accordance with the provisions of Section 4 of the Plan as follows:

          a. Right to Exercise. You may purchase twenty-five percent (25%) of
     the Shares with respect to which the Option has been granted on and after
     the first anniversary of the date of the grant, and an additional
     twenty-five percent (25%) of the Shares with respect to which the Option
     has been granted on and after each of the three (3) succeeding
     anniversaries of said date. Installments or portions thereof not exercised
     in earlier periods shall be accumulated and be available for exercise in
     later periods. In exercising the Option, you may exercise less than the
     full installment available, but each exercise must be in full Shares. You
     are limited to ten (10) exercises during the term of the Option. The Option
     may
<PAGE>   2
     be exercised by paying in accordance with the terms as provided for in
     Section 4 hereof. Upon payment of the Option Price, the Shares so purchased
     shall be delivered to you; provided, however, until the Option is paid, you
     shall not be considered a holder of any Shares purchased pursuant hereto.
     The exercise of the Option shall be subject to the following additional
     conditions:

               i. No Option may be exercised within one (1) year after the date
          on which the Option is granted; ii. Any Option received, other than by
          employees described in Section 3.2 of the Plan, must be exercised
          within ten (10) years after the date on which the Option is granted.

               iii. Each Option may be exercised in part or in full, but must be
          exercised in the order in which each Option is granted. As long as a
          previously issued Option has not been completely exercised, or has not
          lapsed, no subsequently issued Option may be exercised.

               iv. No Option may be exercised during a calendar year which would
          result in the purchase of Shares of the Company having an aggregate
          fair market value (determined at the time of the grant of the Option)
          in excess of One Hundred Thousand Dollars ($100,000.00), except and to
          the extent that such Options were first exercisable in preceding
          calendar years.

          b. Method of Exercise. This Option shall be exercisable by written
     notice, a form of which is attached hereto as Schedule A, which shall state
     the election to exercise the Option, the number of Shares with respect to
     which the Option is being exercised, and such other representations and
     agreements as may be required by the Company with respect to

                                       2
<PAGE>   3
     such Shares. No Shares will be issued upon the exercise of an Option unless
     such issuance and such exercise shall comply with all relevant provisions
     of law and the requirements of any stock exchange upon which the Shares may
     then be issued. Assuming such compliance, for income tax purposes, the
     Shares shall be considered transferred to you on the date on which the
     Option is exercised with respect to such Shares.


     4.   Method of Payment. Payment for Shares purchased upon any exercise of
an Option granted hereby shall be made in full in cash or its equivalent
concurrently with such exercise, except that, if the Company is not then
prohibited from purchasing or acquiring Shares, such payment may be made in
whole or in part with shares of the same class of stock as that which are then
subject to the Option, delivered in lieu of cash concurrently with such
exercise, the shares so delivered to be valued on the basis of the fair market
value of the stock determined in accordance with the procedure specified in
Section 4.1 of the Plan on the day preceding the date of exercise.

     5.   Restriction on Exercise. This Option may not be exercised if the
issuance of such Shares, upon such exercise or the method of payment of
consideration for such Shares, would constitute a violation of any applicable
federal or state securities or other law or regulation.

     6.   Factors Relating to Employment.

          a.   Termination of Employment. If, prior to the termination of the
     Plan, you cease to be employed by the Company, other than by reason of
     death or disability, each Option shall be exercisable only for a period of
     three (3) months from the date of the cessation of employment or the Option
     expiration date, whichever is earlier. Thereafter, all unexercised Options
     and the rights thereunder shall terminate.

          b.   Disability of Employee. If, prior to the termination of the Plan,
     you cease to be employed by the Company by reason of a disability, as
     defined in Section 22(e)(3) of the

                                       3
<PAGE>   4
     Code, you shall be entitled to exercise each Option within one (1) year
     from the cessation of employment or on the Option expiration date,
     whichever is earlier. Thereafter, all unexercised Options and the rights
     thereunder shall terminate. Notwithstanding the provisions of this
     paragraph, however, if you shall be discharged for cause (which shall be
     defined as participation in conduct during employment consisting of fraud,
     felony, willful misconduct or commission of any act which causes or may
     reasonably be expected to cause substantial damage to the Company), each
     Option to the extent not previously exercised shall terminate at once.

          c.   Death of Employee. If, prior to the termination date of the Plan,
     you die while holding an Option, the Option may be exercised, to the same
     extent that you could have exercised the Option at the time of death, by
     your estate or by a person who acquired the right to exercise the Option by
     a written designation, a form of which is attached hereto as Schedule B,
     made by you, or by bequest, inheritance or under the laws of descent and
     distribution of the applicable jurisdiction. The Option shall be exercised
     within the earlier of one (1) year after your death or upon the Option
     expiration date.


     7.   Transferability of the Option. The Option granted hereby shall be
nontransferable by you other than by will or the laws of descent and
distribution and is exercisable during your lifetime only by you or by your
guardian or legal representative. Nothing shall preclude you from designating
the person who after your death may exercise the Option pursuant to the Plan. If
you attempt to alienate, assign, hypothecate, pledge or otherwise dispose of any
Option, except as herein provided, or in the event of attachment, execution or
similar process upon the rights or interest herein conferred, the Option shall
become immediately null and void and without legal effect.

     8.   Term of the Option. This Option may not be exercised more than ten
(10) years from

                                       4
<PAGE>   5
the date of the grant of this Option and may be exercised during such term only
in accordance with the terms of the Plan and the terms of this Option.

     9.   Restricted Stock. Shares of the Company's Common Stock issued upon the
exercise of this Option may, upon the issuance, be subject to the following
restrictions:

          a.   Such Shares (hereinafter referred to as "Restricted Stock") may
     not be sold or otherwise transferred or hypothecated, unless in accordance
     with the terms hereof and the terms of the Plan;

          b.   If the employment of the holder of the Restricted Stock with the
     Company or a subsidiary is terminated for any reason other than by death,
     normal or early retirement in accordance with the Company's established
     retirement policies or practices, or total disability, the Company (or any
     subsidiary designated by the Company) shall have the option for sixty (60)
     days after such termination of employment to purchase for cash all or any
     part of the Restricted Stock granted to you at the fair market value of the
     Restricted Stock on the date of such termination of employment as set forth
     in Section 6 hereof.

The restrictions imposed under Section 8.1 of the Plan shall apply as well to
all Shares or other securities issued in respect of the Restricted Stock in
connection with any stock split, reverse stock split, stock dividend,
recapitalization, reclassification, spin-off, split-off, merger, consolidation
or reorganization. Any and all Shares received upon the exercise of this Option
shall bear the following legend:

                 The securities represented by this certificate
                 have not been registered under the Securities
                 Act of 1933 of the United States of America, as
                 amended (the "Act"), and may not be sold or
                 transferred in the absence of an effective
                 registration statement under the Act or an

                                       5

<PAGE>   6
                 exemption from registration thereunder.


Date of Grant:                    DEPRENYL USA, INC.


*

                                  By:
                                     -------------------------------------------
                                     Dr. D. Geoffrey Shulman,
                                     President and CEO

     OPTIONEE ACKNOWLEDGES AND AGREES THAT THE VESTING OF SHARES PURSUANT TO
SECTION 3 HEREOF IS EARNED ONLY BY CONTINUING EMPLOYMENT AT THE WILL OF THE
COMPANY (NOT THROUGH THE ACT OF BEING HIRED, BEING GRANTED THIS OPTION, OR
ACQUIRING SHARES HEREUNDER). OPTIONEE FURTHER ACKNOWLEDGES AND AGREES THAT
NOTHING IN THIS AGREEMENT, NOR IN THE COMPANY'S INCENTIVE STOCK OPTION PLAN
WHICH IS INCORPORATED HEREIN BY REFERENCE, SHALL CONFER UPON OPTIONEE ANY RIGHT
WITH RESPECT TO CONTINUATION OF EMPLOYMENT BY THE COMPANY, NOR SHALL IT
INTERFERE, IN ANY WAY, WITH HIS/HER RIGHT, OR THE COMPANY'S RIGHT, TO TERMINATE
HIS/HER EMPLOYMENT AT ANY TIME, WITH OR WITHOUT CAUSE.


                                       6
<PAGE>   7
     OPTIONEE ACKNOWLEDGES RECEIPT OF A COPY OF THE PLAN AND CERTAIN INFORMATION
RELATED THERETO AND REPRESENTS THAT HE/SHE IS FAMILIAR WITH THE TERMS AND
PROVISIONS THEREOF AND HEREBY ACCEPTS THIS OPTION SUBJECT TO ALL OF THE TERMS
AND PROVISIONS THEREOF. OPTIONEE HAS REVIEWED THE PLAN AND THIS OPTION, IN THEIR
ENTIRETY, HAS HAD AN OPPORTUNITY TO OBTAIN ADVICE OF COUNSEL PRIOR TO EXECUTING
THIS OPTION, AND FULLY UNDERSTANDS ALL PROVISIONS OF THE OPTION. OPTIONEE HEREBY
AGREES TO ACCEPT AS BINDING, CONCLUSIVE AND FINAL, ALL DECISIONS AND
INTERPRETATIONS OF THE BOARD, UPON ANY QUESTIONS ARISING UNDER THE PLAN.
OPTIONEE FURTHER AGREES TO NOTIFY THE COMPANY UPON ANY CHANGE IN RESIDENCE
ADDRESS.

                                           OPTIONEE

                                           -------------------------------------
                                           *

Residence Address:                         *

                                       7
<PAGE>   8
                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:  The Secretary of Deprenyl USA, Inc.

     Pursuant to the terms and subject to the conditions set forth in the
Incentive Stock Option Agreement (the "Agreement") dated              , between
Deprenyl USA, Inc. and the undersigned, I hereby elect to purchase        shares
of Common Stock of Deprenyl USA, Inc. I understand that such purchase is subject
to all the terms and conditions of the Agreement. I request that the
certificates for such shares of Common Stock shall be issued in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

     In full payment of the purchase price with respect to the Optioned Shares
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian
currency to the order of Deprenyl USA, Inc.

Dated:                               X
                                      ------------------------------------------
                                         (Signature)

                                         ---------------------------------------
                                         Name (Please Print)

                                         ---------------------------------------
                                         (Address)

                                         ---------------------------------------
                                         Taxpayer Identification Number
<PAGE>   9
                                   SCHEDULE B

                         DESIGNATION OF BENEFICIARY FORM

1.   Name of Plan ("Plan"):
                              --------------------------------------------------

2.   Name of Participant ("Participant"):
                                          --------------------------------------

3.   Name of Participant's Spouse ("Spouse"):
                                              ----------------------------------

4.   Any designation previously made by the Participant of the beneficiary who
     may exercise options granted to the Participant under the Plan by reason of
     the death of such Participant is canceled by the designation of any other
     beneficiary in this form.

5.   BENEFICIARY DESIGNATION.
     The Beneficiary who may exercise options granted to the Participant under
     the terms of the Plan by reason of the death of the Participant shall be:

(a)  Primary:

     Name                                     Relationship
          --------------------                             ---------------------

     Address
                  --------------------------------------------------------------

(b)  Secondary:
                  --------------------------------------------------------------

     ---------------------------------------------------------------------------


6.   This Designation of Beneficiary Form may be revoked or changed at any time
     by a written form acceptable to the Company which is signed by the
     Participant and delivered to the Company's Secretary at Lane and Mantell,
     991 Route 22 West, Post Office Box 8539, Bridgewater, New Jersey 08876.

In witness whereof, the Participant has signed this application on the date
hereafter indicated.


Dated:
      ------------------      ---------------------------------



                                       9

<PAGE>   1
                                                                    Exhibit 99.2


                             STOCK OPTION AGREEMENT

     THIS AGREEMENT is made as of the *nd day of *, 199* between DUSA
PHARMACEUTICALS, INC., a corporation incorporated under the laws of the State of
New Jersey (hereinafter referred to as the "Company") and *, an individual
residing in * (hereinafter referred to as the "Participant").

                                   WITNESSETH:

     WHEREAS, the Board of Directors of the Company has determined that in
consideration for services rendered on the Company's behalf and in order to
provide an inducement to the Participant to acquire a proprietary interest in
the Company, it is in the Company's best interest to grant him an option to
purchase Shares on the terms and conditions set forth in this Agreement.

     NOW, THEREFORE, in consideration of the mutual covenants and conditions
expressed herein, it is agreed by and between the parties as follows:

1.1  DEFINITIONS

     In this Agreement:

     "Board of Directors" means the board of directors of the Company;

     "Exercise Price" means *;

     "Expiration Date" means 5:00 p.m. (Eastern Standard Time) on the later of
     the dates provided in Section 2.2;

     "Optioned Shares" means that number of Shares which are subject to the
     option granted by the Company to the Participant pursuant to this
     Agreement; and

     "Shares" means shares of Common Stock in the share capital of the Company.

2.1  GRANT OF OPTION

     Subject to shareholder approval, the Company hereby grants to the
     Participant an option to purchase, in accordance with the vesting rights
     outlined in Sections 2.6 and 2.7 hereof, up to * Shares for an amount per
     Share equal to the Exercise Price, upon the terms and subject to the
     conditions herein contained. This grant is automatic pursuant to the
     Company's Restricted Stock Option Plan and Rule 16b-3(c)(2)(ii) of the
     General Rules and Regulations under the Securities Exchange Act of 1934, as
     amended from time to time.

2.2  Subject to Sections 2.6, 2.7 and 3.1 hereof, the Participant shall have the
     right, at any time prior to 5:00 p.m. (Eastern Standard Time) on the tenth
     anniversary date hereof, being *,
<PAGE>   2
     provided that if such day is not a day on which the Company is open for
     business then on the first following day on which the Company is open for
     business, to exercise this option for any number of the Optioned Shares up
     to the maximum number of Shares specified in Section 2.1 above.

2.3  The option may be exercised by the Participant or by his executors or
     personal representatives in the circumstances described in Section 4.1 by
     giving to the Company at its registered office notice in writing in the
     form of Schedule A hereto setting out the number of Optioned Shares with
     respect to which the option is being exercised. The notice must be
     accompanied by a certified check, official bank cashier's check or money
     order in an amount equal to the Exercise Price multiplied by the number of
     Shares requested and a duly executed copy of this Agreement.

2.4  The Company shall cause its registrar and transfer agent to deliver to the
     Participant as soon as practicable after receipt of such notice and payment
     a certificate or certificates registered in the name of the Participant or
     as the Participant may direct for the number of Shares with respect to
     which the option is duly exercised.

2.5  Nothing contained in this Agreement or done pursuant hereto shall obligate
     the Participant to purchase and/or pay for, or the Company to issue, any
     Shares except those Optioned Shares with respect to which the Participant
     shall have duly exercised the option to purchase in accordance with this
     Agreement.

2.6  Subject to Sections 2.1 and 2.7 hereof, the option granted hereunder shall
     vest in the Participant in the following manner:

     (a)  one-quarter of the option on the first anniversary of the day
          immediately preceding the date hereof, being *;

     (b)  one-quarter of the option on the second anniversary of the day
          immediately preceding the date hereof, being *;

     (c)  one-quarter of the option on the third anniversary of the day
          immediately preceding the date hereof, being *; and

     (d)  one-quarter of the option on the fourth anniversary of the day
          immediately preceding the date hereof, being *;

     and, except as provided by Section 6.1, the Participant shall only be
     entitled to exercise this option in the amounts set out above and from and
     after the dates so specified.

2.7  Notwithstanding anything contained in Sections 2.1 and 2.6 hereof, options
     shall continue to vest in the Participant only so long as the Participant
     shall continue to serve the Company as a director and/or officer. Should
     the Participant cease to serve in such capacity (the "Termination"), no
     further options shall vest or become exercisable, except at the discretion
     of the Board of Directors, and the provisions of Section 3.1 shall apply
     with respect to the exercise of those options which have already vested in
     the Participant and have not yet been

                                       2
<PAGE>   3
     exercised. The Board of Directors shall be entitled to determine if and
     when Termination has occurred with respect to the Participant.

3.1  EXPIRATION ON TERMINATION

     Subject to Section 4.1 hereof, upon Termination, such part of the option as
     is then exercisable but unexercised may be exercised by the Participant for
     a period of ninety (90) days after Termination or such later date as the
     Board of Directors may approve after which time this option shall expire;
     provided, however, that in no event may this option be exercised after the
     Expiration Date.

4.1  DEATH OR PERMANENT DISABILITY OF EMPLOYEE

     In the event that on or prior to the Expiration Date, the Participant dies
     or becomes totally and permanently disabled while serving the Company as a
     director or officer, this option, to the extent then exercisable but
     unexercised, may be exercised by the Participant for a period of six (6)
     months after the death or disability of the Participant, notwithstanding
     the Expiration Date. The Board of Directors shall be entitled to determine
     if and when a Participant has become permanently disabled. For the purposes
     of this provision only, reference to the Participant in this Agreement
     shall be construed as including the executors or personal representatives
     of a deceased Participant. In the event that this option is not exercised
     within the period of six (6) months set out above, this option shall
     expire.

5.1  SUBDIVISION, CONSOLIDATION OR REORGANIZATION

     (a)  In the event of any subdivision, redivision or change of the Shares of
     the Company into a greater number of Shares at any time after the date of
     this Agreement and prior to the Expiration Date of this option, the Company
     shall deliver at the time of exercise of this option, but for the same
     aggregate consideration payable therefor, such additional number of Shares
     as the Participant would have been entitled to receive as a result of such
     subdivision, redivision or change if on the record date thereof the
     Participant had been the registered holder of the number of such Shares
     with respect to which the option is later exercised.

     (b)  In the event of any consolidation or change of the Shares of the
     Company into a lesser number of Shares at any time after the date of this
     Agreement and prior to the expiration of this option, the Company shall
     deliver at the time of exercise of this option, but for the same aggregate
     consideration payable therefor, such reduced number of Shares, as the
     Participant would have been entitled to receive upon such consolidation or
     change if on the record date thereof the Participant had been the
     registered holder of the number of such Shares with respect to which the
     option is later exercised.

     (c)  If at any time after the date of this Agreement and prior to the
     expiration of this option, the Shares shall be reclassified or reorganized,
     otherwise than as specified in Sections 5.1(a) and (b), the Participant
     shall be entitled to receive upon the exercise of this option and shall
     accept in lieu of the number of Shares then subscribed for, but for the
     same aggregate consideration payable therefor, the same aggregate number of
     shares of the appropriate class

                                       3
<PAGE>   4
     of shares that the Participant would have been entitled to receive as a
     result of such reclassification or other reorganization of Shares if on the
     record date thereof the Participant had been the registered holder of the
     number of such Shares with respect to which the option is later exercised.

6.1  TENDER OFFER

     If an offeror makes an offer to purchase 50% or more of the outstanding
     Shares to substantially all holders of the Shares or, if an insider of the
     Company makes an offer to purchase Shares to substantially all holders of
     the Shares, and the Board of Directors recommends acceptance of such offer
     to the shareholders of the Company and the offer price is greater than the
     Exercise Price, then this option, whether or not it has vested in whole or
     in part in the Participant, shall become immediately exercisable. The
     Participant shall be bound to exercise this option and to tender the
     Optioned Shares issued upon exercise of this option into the offer upon
     receipt of notice from the Company if the Company provides an interest-free
     loan to the Participant in the amount of the Exercise Price for all of the
     Optioned Shares issuable upon exercise of this option, subject to the
     execution of a security agreement by the Participant in favor of the
     Company securing repayment of the loan.

7.1  NO ASSIGNMENT

     The Participant may not assign, transfer, pledge or hypothecate any of his
     rights hereunder in any way (whether by operation of law or otherwise)
     except by will or by the laws of succession on intestacy which may apply to
     the estate of the Participant upon his death. The option granted herein
     shall not be subject to execution, attachment or similar process. Upon any
     attempt to assign, transfer, pledge, hypothecate or otherwise dispose of
     this option contrary to the provisions hereof, or upon the levy of any
     attachment or similar process upon the option granted herein, such option
     shall immediately become void.

8.1  GENERAL

     (a)  Time shall be of the essence of this Agreement.

     (b)  In this Agreement, words importing the singular number include the
     plural and vice versa and words importing the masculine gender include the
     feminine and neuter genders.

     (c)  All notices which may be or are required to be given by one party to
     the other party pursuant to this Agreement shall be in writing and shall be
     mailed by first class or certified mail, return receipt requested, postage
     prepaid, or transmitted by hand delivery as follows:

     If to the Company:                   DUSA Pharmaceuticals, Inc.
                                          6870 Goreway Drive
                                          Mississauga, ON L4V 1P1
                                          CANADA

                                          Attention:  Dr. D. Geoffrey Shulman

                                       4
<PAGE>   5
     If to the Participant:               *

                                          at the address of the Participant from
                                          time to time in the records of the
                                          Company,

     or such other address as to which either party may from time to time notify
     the other as aforesaid.

9.1  RESTRICTIONS ON TRANSFER

     The Participant understands and acknowledges that he is subject to certain
     restrictions on transfer under the Securities Act of 1933 of the United
     States, as amended, (the "1933 Act") of the Shares issued pursuant to the
     exercise of the option; such restrictions provide that the Shares may not
     be sold without registration or exemption from registration under the 1933
     Act; and, for purposes of the Securities Act (Ontario) (the "Ontario Act"),
     the first trade of such Shares, other than a trade exempted by the Ontario
     Act, will be a distribution unless the Company has been a reporting issuer
     for at least twelve (12) months and the Company is not in default of any
     requirement of the Ontario Act, disclosure has been made to the Ontario
     Securities Commission of the exempt trade, no unusual effort is made to
     prepare the market or create a demand for the Shares, and no extraordinary
     commission or consideration is paid with respect to the trade, provided
     that such first trade is not from the holdings of a so-called "control
     block".

10.1 REPORTING REQUIREMENTS

     The Participant understands and acknowledges that he may be subject to
     certain reporting requirements upon his receipt and exercise of the option,
     and in connection therewith, upon the receipt and exercise of the option,
     the Participant agrees to timely file with the Securities and Exchange
     Commission, the National Association of Securities Dealers, Inc., and any
     appropriate Canadian securities regulatory authorities, the appropriate
     documentation regarding his ownership of the Company's securities.

     IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
hereto.

Attest:                              DUSA PHARMACEUTICALS, INC.,
                                     a New Jersey corporation


                                     By:
- -----------------------------           -----------------------------------
Nanette W. Mantell, Secretary           Dr. D. Geoffrey Shulman, President


                                     PARTICIPANT

                                     --------------------------------------

                                       5
<PAGE>   6



                                        *


                                       6
<PAGE>   7
                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:  The Secretary of DUSA Pharmaceuticals, Inc.

     Pursuant to the terms and subject to the conditions set forth in the Stock
Option Agreement (the "Agreement") dated         , between DUSA Pharmaceuticals,
Inc. and the undersigned, and Stock Options granted to the undersigned by such
Agreement, I hereby elect to purchase             shares of Common Stock of DUSA
Pharmaceuticals, Inc. which were the subject of such Stock Options. I understand
that such purchase is subject to all the terms and conditions of the Agreement.
I request that the certificates for such shares of Common Stock shall be issued
in the name of:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------

- -------------------------------------------------------------------------------
                     (please print or type name and address)

     (a) The Shares are being purchased for the undersigned's own account, for
investment purposes only, and not for the account of any other person, and not
with a view to distribution, assignment, or resale to others, or to
fractionalization in whole or in part and that the offering and sale of the
Shares is intended to be exempt from registration under the Securities Act of
1933 (the "Act"). In furtherance thereof, the undersigned represents, warrants
and agrees as follows: (i) no other person has or will have a direct or indirect
beneficial interest in such Share and the undersigned will not sell,
hypothecate, or otherwise transfer his shares except in accordance with the Act
and applicable state securities laws or unless in the opinion of counsel for the
Company, an exemption from the registration requirements of the Act and such
laws is available; and (ii) the Company is under no obligation to register the
Shares on behalf of the undersigned or to assist the undersigned in complying
with any exemption from registration.
<PAGE>   8
     (b) The undersigned has such knowledge and experience in financial and
business matters that the undersigned is capable of evaluating the merits and
risks of investment in the Company and of making an informed investment
decision.

     In full payment of the purchase price with respect to the Stock Options
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian or
United States currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                         X
                                ------------------------------------------------
                                           (Signature)

                                           -------------------------------------
                                           Name (Please Print)

                                           -------------------------------------
                                           (Address)

                                           -------------------------------------
                                           Taxpayer Identification Number


                                       8

<PAGE>   1

                                                                    Exhibit 99.3

                       NONQUALIFIED STOCK OPTION AGREEMENT
       UNDER THE DUSA PHARMACEUTICALS, INC. 1996 OMNIBUS PLAN, AS AMENDED

         AGREEMENT made and entered into as of the ___ day of _______, 199_, by
and between DUSA Pharmaceuticals, Inc., a corporation incorporated under the
laws of the State of New Jersey (the "Company"), and
_____________________________, an individual residing in the State of (the
"Grantee").

         WHEREAS, pursuant to the DUSA Pharmaceuticals, Inc. 1996 Omnibus Plan,
as amended (the "Plan"), the Company has determined that its interests will be
advanced by providing an incentive to the Grantee to acquire a proprietary
interest in the Company and, as a shareholder, to share in its success, with
added incentive to work effectively for and in the Company's interest;

         NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, the parties hereby agree as follows:

                                    SECTION 1
                                      GRANT

         1.1    The Company hereby grants to the Grantee, as a matter of
         separate agreement and not in lieu of salary or any other compensation
         for services, the right and option (the "Option") to purchase, in
         accordance with the vesting rights outlined in Sections 3.1 and 3.6
         hereof, up to ! shares of authorized but unissued Common Stock, without
         par value ("Common Stock"), of the Company on the terms and conditions
         herein set forth in this Agreement. [For directors grants add the
         following: This grant is automatic pursuant to the Plan.]

                                    SECTION 2
                                      PRICE

         2.1    The purchase price of the shares of Common Stock subject to this
         Option shall be the fair market value of the shares of Common Stock on
         the date of the grant ($ per share)(the "Exercise Price").

                                    SECTION 3
                                WHEN EXERCISABLE

         3.1    The aggregate number of shares of Common Stock of the Company
         optioned by this Agreement (the "Optioned Shares") shall vest in the
         Grantee as follows:

                  (a)      one-quarter of the Option on the first anniversary of
                           the day of the grant, being ;


<PAGE>   2




                  (b)      one-quarter of the Option on the second anniversary
                           of the day of the grant, being   ;

                  (c)      one-quarter of the Option on the third anniversary of
                           the day of the grant, being   ; and

                  (d)      one-quarter of the Option on the fourth anniversary
                           of the day of the grant, being   ;

         and, except as provided by Sections 3.6 and 6.3 hereof, the Grantee
         shall only be entitled to exercise this Option, in whole or in part, in
         the amounts set out above and from and after the dates so specified.

         3.2    Subject to Sections 3.1 and 3.6 hereof, the Grantee shall have
         the right, at any time prior to 5:00 p.m. (Eastern Standard Time) on
         the date prior to the tenth anniversary date hereof, being  , provided
         that if such day is not a day on which the Company is open for business
         then on the first following day on which the Company is open for
         business, to exercise this Option for any number of the Optioned Shares
         up to the maximum number of shares specified in Section 1.1 above.

         3.3    No less than one thousand (1,000) shares may be purchased upon
         any one exercise of the Option granted hereby unless the number of
         shares purchased at such time is the total number of shares in respect
         of which the Option hereby granted is then exercisable.

         3.4    In no event shall any Option granted hereby be exercisable for a
         fractional share.

         3.5    From time to time, in its discretion, the Committee may offer
         the Grantee the right to cancel any Option granted hereunder in
         exchange for such consideration as the Committee shall determine.

         3.6    Notwithstanding anything contained in Sections 1 and 3.1 hereof,
         the Option shall continue to vest in the Grantee only so long as the
         Grantee shall continue to serve the Company. Should the Grantee cease
         to serve in all such capacities, the Option shall not further vest or
         become exercisable, and the provisions of Section 5.2 shall apply with
         respect to the exercise of the Option which has already vested in the
         Grantee and has not yet been exercised. The Board of Directors shall be
         entitled to determine if and when employment or service to the Company
         has ceased with respect to the Grantee.

                                    SECTION 4
                                 HOW EXERCISABLE

         4.1    Subject to such administrative regulations as the Committee may
         from time to time adopt, the Grantee or beneficiary shall, in order to
         exercise this Option give to the Company at its principal office notice
         in writing in the form of Schedule A hereto setting out the number of
         Optioned Shares with respect to which the Option is being exercised.
         The notice must be accompanied by payment of a certified check,
         official bank cashier's check or money order in an amount equal to the
         Exercise Price multiplied by the number of shares requested and a duly
         executed copy of this Agreement.


                                       -2-
<PAGE>   3




         4.2    Any notice under this Section shall include an undertaking to
         furnish or execute such documents as the Committee in its discretion
         shall deem necessary (i) to evidence such exercise, in whole or in
         part, of the Option evidenced by this Agreement, (ii) to determine
         whether registration is then required under the Securities Act of 1933,
         or any other law, as then in effect, and (iii) to comply with or
         satisfy the requirements of the Securities Act of 1933, or any other
         law, as then in effect.

         4.3    The Grantee agrees that all shares purchased by him or her under
         the Option will be acquired for investment, not distribution, and that
         any notice of exercise of the Option must be accompanied by a written
         representation to that effect, signed by the Grantee.

                                    SECTION 5
                              TERMINATION OF OPTION

         5.1    The Option granted hereby shall terminate and be of no force or
         effect upon the expiration of ten years from the date of the Grant
         unless terminated prior to such time as provided below.

         5.2    Subject to Section 3.6 hereof, should the Grantee cease to serve
         the Company, the Grantee's Option shall be exercised as follows:

                  (a) If the Grantee's termination of employment or service is
                  other than for cause or for the reasons provided in
                  subsections (b)-(d) below, the Option may be exercised, to the
                  extent exercisable, for a period of three months after the
                  date of such termination of employment;

                  (b) If the Grantee's termination of employment or service is
                  by reason of retirement or disability, the Option may be
                  exercised, to the extent exercisable, for a period of 12
                  months after the date of such termination;

                  (c) In the event of death of the Grantee after termination of
                  employment or service pursuant to (a) or (b) above, the person
                  or persons to whom the Grantee's rights are transferred by
                  will or the laws of descent and distribution shall have a
                  period of three years from the date of termination of the
                  Grantee's employment or service to exercise the Option which
                  could have been exercised during such period; and

                  (d) In the event of death of the Grantee while employed, the
                  Option shall become fully and immediately exercisable and may
                  be exercised by the person or persons to whom the Grantee's
                  rights are transferred by will or the laws of descent and
                  distribution for a period of three years after the Grantee's
                  death, subject to exercise during the remaining term of the
                  Option;

         5.3    Any determination made by the Committee with respect to any
         matter referred to in this Section 5 shall be final and conclusive on
         all persons affected thereby. Employment by, or service to, the Company
         shall be deemed to include employment by, or service to, any subsidiary
         of the Company by the Grantee.


                                      -3-
<PAGE>   4




                                       -4-
<PAGE>   5

                                    SECTION 6
                              ADJUSTMENTS TO OPTION

         6.1    Subject to any required action by the Committee and the
         Company's shareholders, the number of shares provided for in the
         Option, the price per share thereof and the number of shares provided
         for in the Plan shall be proportionately adjusted for any increase or
         decrease in the number of issued shares of the Company resulting from
         the payment of a share dividend, a share split or any transaction which
         is a "corporate transaction" (as defined in the Treasury regulations
         promulgated under Section 424 of the Code.

         6.2    Subject to any required action by the Committee and the
         Company's shareholders, if the Company shall be the surviving entity in
         any merger or consolidation, or after a consolidation of the Company
         and one or more entities in which the resulting entity is an
         independent entity, the Option shall pertain to and apply to the
         securities of the surviving entity in an amount that the board of
         directors of the surviving entity, at its sole discretion, determines
         to be equivalent, as nearly as practicable, to the nearest whole number
         and class of shares that were subject to the Option. These shares of
         stock or other securities shall, after such merger or consolidation, be
         deemed to be shares for all purposes of the Plan. The aforesaid
         adjustments, when applicable, shall be made by the Committee, and the
         Committee's determination shall be final, binding and conclusive.

         6.3    In the event of a Change of Control (as defined below), any and
         all outstanding Options not fully vested shall automatically vest in
         full and shall be immediately exercisable. The date on which such
         accelerated vesting and immediate exercisability shall occur shall be
         the date of the occurrence of the Change of Control.

                A "Change of Control" shall be deemed to have taken place upon
         (i) the acquisition by a third person, including a "group" as defined
         in Section 13(d)(3) of the Securities Exchange Act of 1934, as amended,
         of shares of the Company having 50% or more of the total number of
         votes that may be cast for the election of Directors of the Company;
         (ii) shareholder approval of a transaction for the acquisition of the
         Company, or substantially all of its assets by another entity or for a
         merger, reorganization, consolidation or other business combination to
         which the Company is a part; or (iii) the election during any period of
         24 months or less of 50% or more of the Directors of the Company where
         such Directors were not in office immediately prior to such period
         provided, however, that no "Change of Control" shall be deemed to have
         taken place if the Directors of the Company in office on the date of
         adoption of the Plan, or their successors in office nominated by such
         Directors, affirmatively approve a resolution to such effect.

                Except as provided with respect to a Grantee in his or her
         stock option agreement or other controlling agreement between him or
         her and the Company, to the extent that the acceleration,
         exercisability or parachute payment attributable to the Option
         following a Change of Control would result in "excess parachute
         payments"(1) when the former are aggregated with other payments or
         benefits to the Grantee (whether or not payable by the Plan), such
         parachute payments or benefits provided to a Grantee under this
         Agreement shall


- --------
     (1)"Excess parachute payments" are defined in Section 280G of the Code and
are determined by tax counsel of the Company.



                                       -5-
<PAGE>   6




         be reduced to the extent necessary so that no portion thereof shall be
         subject to the excise tax imposed by Section 4999 of the Code. This
         reduction will only be made if it will cause the Grantee's net
         after-tax benefit to exceed the net after-tax benefit that would have
         existed if such reduction were not made. "Net after-tax benefit" shall
         be the sum of (i) all payments and benefits which a Grantee receives or
         is entitled to receive that would constitute a "parachute payment"
         under Section 280G of the Code, less (ii) the amount of federal income
         taxes payable with respect to the payments and benefits described in
         (i) above, calculated at the maximum marginal income tax rate(2) for
         the year in which such payments and benefits shall be paid to the
         Grantee, less (iii) the amount of excise taxes imposed with respect to
         the payments and benefits described in (i) above by Section 4999 of the
         Code.

         6.4    In the event of a change in the Company's shares which is
         limited to a change of all of its authorized shares with par value into
         the same number of shares with a different par value or without par
         value, the shares resulting from any such change shall be deemed to be
         shares within the meaning of the Plan.

         6.5    Except as herein before expressly provided in Paragraphs 6.1,
         6.2, 6.3 and 6.4 of this Section 6, the Grantee shall have no rights by
         reason of any subdivision or consolidation of shares of any class or
         payment of any share dividend or any other increase or decrease in the
         number of shares of any class or by reason of any dissolution,
         liquidation, merger, consolidation or spin-off of assets or stock of
         another corporation and any issuance by the Company of shares of any
         class, or securities convertible into shares of any class, shall not
         affect the Option, and no adjustment by reason thereof shall be made
         with respect to the number or price of the Company's shares subject to
         the Option. The grant of the Option shall not affect in any way the
         right or power of the Company to make adjustments, reclassifications,
         reorganizations or changes of its capital or business structure or to
         merge, consolidate, dissolve, liquidate, sell or transfer all or any
         part of its business or assets.

                                    SECTION 7
                                    TRANSFER

         7.1    This Option shall not be transferable by any individual Grantee
         in any way other than by will and the laws of descent and distribution.
         During the lifetime of any individual Grantee, the Option shall be
         exercisable only by him or her. Any other attempted assignment,
         transfer, pledge, hypothecation or other disposition of the Option by
         any Grantee shall be void and have no effect unless in accordance with
         the terms set forth herein.

                                    SECTION 8
                                WITHHOLDING TAXES

         8.1    The Company shall have the right to retain and withhold from any
         payment, under the Option granted, any amount that is to be withheld or
         otherwise deducted and paid with respect to such payment. At its
         discretion, the Company may require the Grantee, if he or

- --------------------
     (2)"This rate is based on the rate for the year set forth in the Code at
the time of the first payment to the participant.


                                       -6-
<PAGE>   7





         she receives shares under a nonqualified stock option grant, to
         reimburse the Company for any taxes that are required to be withheld by
         the Company, and may withhold any distribution in whole or in part
         until the Company is so reimbursed. In lieu thereof, the Company shall
         have the right to withhold from any other cash amounts due (or to
         become due) to the Grantee an amount equal to such taxes required to be
         withheld by the Company to reimburse the Company for any such taxes, or
         the Company may retain and withhold a number of shares of Common Stock
         having a market value not less than the amount of such taxes and cancel
         (in whole or in part) any shares of Common Stock so withheld in order
         to reimburse the Company for any such taxes.

                                    SECTION 9
                            IMPACT ON OTHER BENEFITS

         9.1    The value of the Option (either on the date of grant of the
         Option or at the time the shares are vested) shall not be includable as
         compensation or earnings for purposes of any other benefit plan offered
         by the Company.

                                   SECTION 10
                                 ADMINISTRATION

         10.1   The Committee shall have full authority and discretion (subject
         only to the express provisions of the 1996 Omnibus Plan, as amended) to
         decide all matters relating to the administration and interpretation of
         the Plan and this Agreement. All such Committee determinations shall be
         final, conclusive and binding upon the Company, the Grantee and any and
         all interested parties.

                                   SECTION 11
                       AGREEMENT TO CONTINUE IN EMPLOYMENT
                           OR SERVICE AS A CONSULTANT

         11.1   Nothing in the Plan or this Agreement shall confer on a Grantee
         any right to continue in the employ of the Company or in the service of
         the Company as a consultant or interfere in any way with the right of
         the Company to terminate his or her employment or consultantship at any
         time.

                                   SECTION 12
                                  AMENDMENT(S)

         12.1   This Agreement shall be subject to the terms of the Plan as
         amended except that the Option that is the subject of this Agreement
         may not in any way be amended or terminated without the Grantee's
         written consent.


                                       -7-
<PAGE>   8




                                   SECTION 13
                                FORCE AND EFFECT

         13.1   The various provisions of this Agreement are severable in their
         entirety. Any determination of invalidity or unenforceability of any
         one provision shall have no effect on the continuing force and effect
         of the remaining provisions.

                                   SECTION 14
                         NOTICE OF DISPOSITION OF SHARES

         14.1   The Grantee agrees that if it, he or she should dispose of any
         shares of Common Stock acquired on the exercise of the Option,
         including a disposition by sale, exchange, gift or transfer of legal
         title within six months of the date such shares are transferred to the
         Grantee, the Grantee will notify the Company promptly of such
         disposition.

                                   SECTION 15
                                     NOTICES

         15.1   All notices which may be or are required to be given by one
         party to the other party pursuant to this Agreement shall be in writing
         and shall be mailed by first class or certified mail, return receipt
         requested, postage prepaid, or transmitted by hand delivery as follows:
<TABLE>
                  <S>                       <C>
                  If to the Company:        DUSA Pharmaceuticals, Inc.
                                            181 University Drive, Suite 1208
                                            Toronto, ON M5H 3M7
                                            CANADA

                                            Attention:  Dr. D. Geoffrey Shulman

                  If to the Grantee:

                                            at the address of the Grantee from
                                            time to time in the records of the
                                            Company,
</TABLE>

                  or such other address as to which either party may from time
                  to time notify the other as aforesaid.

                                       -8-
<PAGE>   9





                                   SECTION 16
                            RESTRICTIONS ON TRANSFER

         16.1   The Grantee understands and acknowledges that it, he or she is
         subject to certain restrictions on transfer under the Securities Act of
         1933 of the United States, as amended, (the "1933 Act") of the shares
         issued pursuant to the exercise of the Option; such restrictions
         provide that the shares may not be sold without registration or
         exemption from registration under the 1933 Act; and, for purposes of
         the Securities Act (Ontario) (the "Ontario Act"), the first trade of
         such shares, other than a trade exempted by the Ontario Act, will be a
         distribution unless the Company has been a reporting issuer for at
         least twelve (12) months and the Company is not in default of any
         requirement of the Ontario Act, disclosure has been made to the Ontario
         Securities Commission of the exempt trade, no unusual effort is made to
         prepare the market or create a demand for the shares, and no
         extraordinary commission or consideration is paid with respect to the
         trade, provided that such first trade is not from the holdings of a
         so-called "control block".

                                   SECTION 17
                             REPORTING REQUIREMENTS

         17.1   The Grantee understands and acknowledges that it, he or she may
         be subject to certain reporting requirements upon his receipt and
         exercise of the Option, and in connection therewith, upon the receipt
         and exercise of the Option, the Grantee agrees to timely file with the
         Securities and Exchange Commission, the National Association of
         Securities Dealers, Inc., and any appropriate Canadian securities
         regulatory authorities, the appropriate documentation regarding his
         ownership of the Company's securities.

                                   SECTION 18
                                  GOVERNING LAW

         18.1   This Agreement shall be construed and enforced in accordance
         with and governed by the laws of the State of New Jersey.

         IN WITNESS WHEREOF, this Agreement has been duly executed by the
parties hereto.

Attest:                                      DUSA PHARMACEUTICALS, INC.,
                                             a New Jersey corporation

                                             By:
- ----------------------------------           -----------------------------------
Nanette W. Mantell, Secretary                Dr. D. Geoffrey Shulman, President

                                             GRANTEE

                                             -----------------------------------




                                       -9-
<PAGE>   10

                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:      The Secretary of DUSA Pharmaceuticals, Inc.

         Pursuant to the terms and subject to the conditions set forth in the
Nonqualified Stock Option Agreement (the "Agreement") dated    , between DUSA
Pharmaceuticals, Inc. and the undersigned, and the Option granted to the
undersigned by such Agreement, I hereby elect to purchase shares     of Common
Stock of DUSA Pharmaceuticals, Inc. which were the subject of such Option. I
understand that such purchase is subject to all the terms and conditions of the
Agreement. I request that the certificates for such shares of Common Stock shall
be issued in the name of:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

         The undersigned hereby represents and warrants to, and agrees with the
Company as follows:

         (a) The shares are being purchased for the undersigned's own account,
for investment purposes only, and not for the account of any other person, and
not with a view to distribution, assignment, or resale to others, or to
fractionalization in whole or in part and that the offering and sale of the
shares is intended to be exempt from registration under the Securities Act of
1933 (the "Act"). In furtherance thereof, the undersigned represents, warrants
and agrees as follows: (i) no other person has or will have a direct or indirect
beneficial interest in such shares and the undersigned will not sell,
hypothecate, or otherwise transfer his shares except in accordance with the Act
and applicable state securities laws or unless in the opinion of counsel for the
Company, an exemption from the registration requirements of the Act and such
laws is available; and (ii) the Company is under no obligation to register the
shares on behalf of the undersigned or to assist the undersigned in complying
with any exemption from registration.

         (b) The undersigned has such knowledge and experience in financial and
business matters that the undersigned is capable of evaluating the merits and
risks of investment in the Company and of making an informed investment
decision.


<PAGE>   11



         In full payment of the purchase price with respect to the Option
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian or
United States currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                X
                       ----------------------------------
                                        (Signature)

                               -----------------------------------------
                                        Name (Please Print)

                               -----------------------------------------
                                        (Address)

                               -----------------------------------------
                                        Taxpayer Identification Number


                                       -11-

<PAGE>   1

                                                                    Exhibit 99.4

                        INCENTIVE STOCK OPTION AGREEMENT
       UNDER THE DUSA PHARMACEUTICALS, INC. 1996 OMNIBUS PLAN, AS AMENDED

         THIS AGREEMENT made as of the  th day of  , 199 , by and between DUSA
Pharmaceuticals, Inc., a corporation incorporated under the laws of the State of
New Jersey (the "Company"), and  (the "Grantee").

         WHEREAS, pursuant to the DUSA Pharmaceuticals, Inc. 1996 Omnibus Plan
(the "Plan"), the Company has determined that its interests will be advanced by
providing an incentive to the Grantee to acquire a proprietary interest in the
Company and, as a shareholder, to share in its success, with added incentive to
work effectively for and in the Company's interest;

         WHEREAS, the Board of Directors of the Company approved a resolution,
effective , 199 , directing the officers of the Company to grant incentive
stock options to certain employees of the Company, subject to regulatory
approval;

         NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, the parties hereby agree as follows:

                                    SECTION 1
                                      GRANT

         1.1      The Company hereby grants to the Grantee, as a matter of
                  separate agreement and not in lieu of salary or any other
                  compensation for services, the right and option (the "Option")
                  to purchase, in accordance with the vesting rights outlined in
                  Sections 3.1 and 3.6 hereof, up to  shares of authorized but
                  unissued Common Stock, without par value ("Common Stock"), of
                  the Company on the terms and conditions herein set forth in
                  this Agreement.

                                    SECTION 2
                                      PRICE

         2.1      The purchase price of the shares of Common Stock subject to
                  this Option shall be the fair market value of the shares of
                  Common Stock on the date of the grant ($  per share)(the
                  "Exercise Price").


<PAGE>   2




                                    SECTION 3
                                WHEN EXERCISABLE

         3.1      The aggregate number of shares of Common Stock of the Company
                  optioned by this Agreement (the "Optioned Shares") shall vest
                  in the Grantee as follows:

                  (a)      one-quarter of the Option on the first anniversary of
                           the day of the grant, being ;

                  (b)      one-quarter of the Option on the second anniversary
                           of the day of the grant, being ;

                  (c)      one-quarter of the Option on the third anniversary of
                           the day of the grant, being ; and

                  (d)      one-quarter of the Option on the fourth anniversary
                           of the day of the grant, being ;

         and, except as provided by Sections 3.6 and 6.3 hereof, the Grantee
         shall only be entitled to exercise this Option, in whole or in part, in
         the amounts set out above and from and after the dates so specified.

         3.2      Subject to Sections 3.1 and 3.6 hereof, the Grantee shall have
                  the right, at any time prior to 5:00 p.m. (Eastern Standard
                  Time) on the date prior to the tenth anniversary date hereof,
                   , provided that if such day is not a day on which the Company
                  is open for business then on the first following day on which
                  the Company is open for business, to exercise this Option for
                  any number of the Optioned Shares up to the maximum number of
                  shares specified in Section 1.1 above.

         3.3      No less than one thousand (1,000) shares may be purchased upon
                  any one exercise of the Option granted hereby unless the
                  number of shares purchased at such time is the total number of
                  shares in respect of which the Option hereby granted is then
                  exercisable.

         3.4      In no event shall any Option granted hereby be exercisable for
                  a fractional share.

         3.5      From time to time, in its discretion, the Committee may offer
                  the Grantee the right to cancel any Option granted hereunder
                  in exchange for such consideration as the Committee shall
                  determine.

         3.6      Notwithstanding anything contained in Sections 1 and 3.1
                  hereof, the Option shall continue to vest in the Grantee only
                  so long as the Grantee shall continue to serve the Company.
                  Should the Grantee cease to serve the Company, the provisions
                  of Section 5.2 shall apply with respect to the vesting and
                  exercise of the Option. The Board of


                                       -2-
<PAGE>   3





                  Directors shall be entitled to determine if and when
                  employment or service to the Company has ceased with respect
                  to the Grantee.

         3.7      To the extent not exercised, installments shall accumulate and
                  be exercisable by the Grantee, in whole or in part, in any
                  subsequent year included in the Option Period but not later
                  than the expiration of the Option Period.

         3.8      The Options shall be exercised in accordance with Section 422
                  of the Internal Revenue Code of regulations as amended. To the
                  extent that the exercise of the Option does not meet the
                  requirements of Section 422 as hereinafter amended, the Option
                  shall be considered a nonqualified stock option.

         3.9      No Option may be exercised during a calendar year which would
                  result in the purchase of shares of the Company having an
                  aggregate fair market value (determined at the time of the
                  grant of the Option ) in excess of One Hundred Thousand
                  Dollars ($100,000.00) except and to the extent that such
                  Option was first exercisable in preceding calendar years.

                                    SECTION 4
                                 HOW EXERCISABLE

         4.1      Subject to such administrative regulations as the Committee
                  may from time to time adopt, the Grantee or beneficiary shall,
                  in order to exercise this Option give to the Company at its
                  principal office notice in writing in the form of Schedule A
                  hereto setting out the number of Optioned Shares with respect
                  to which the Option is being exercised. The notice must be
                  accompanied by payment of a certified check, official bank
                  cashier's check or money order in an amount equal to the
                  Exercise Price multiplied by the number of shares requested
                  and a duly executed copy of this Agreement. At the discretion
                  of the Committee, the Grantee may pay all or a portion of the
                  purchase price by tender of Common Stock or a combination of
                  stock and cash or other means determined by the Committee.

         4.2      Any notice under this Section shall include an undertaking to
                  furnish or execute such documents as the Committee in its
                  discretion shall deem necessary (i) to evidence such exercise,
                  in whole or in part, of the Option evidenced by this
                  Agreement, (ii) to determine whether registration is then
                  required under the Securities Act of 1933, or any other law,
                  as then in effect, and (iii) to comply with or satisfy the
                  requirements of the Securities Act of 1933, or any other law,
                  as then in effect.

         4.3      The Grantee agrees that all shares purchased by him or her
                  under the Option will be acquired for investment, not
                  distribution, and that any notice of exercise of the Option
                  must be accompanied by a written representation to that
                  effect, signed by the Grantee.


                                       -3-
<PAGE>   4




                                    SECTION 5
                              TERMINATION OF OPTION

         5.1      The Option granted hereby shall terminate and be of no force
                  or effect upon the expiration of ten years from the date of
                  the Grant unless terminated prior to such time as provided
                  below.

         5.2      Subject to Section 3.6 hereof, should the Grantee cease to
                  serve the Company, the Grantee's Option shall be exercised as
                  follows:

                  (a) If the Grantee's termination of service is other than for
                  cause, or for the reasons provided in subsections (b) - (d)
                  below, the Option may be exercised, to the extent exercisable,
                  for a period of three months after the date of such
                  termination of employment;

                  (b) If the Grantee's termination of service is by reason of
                  retirement or disability, the Option may be exercised, to the
                  extent exercisable, for a period of 12 months after the date
                  of such termination;

                  (c) In the event of death of the Grantee after termination of
                  service pursuant to (a) or (b) above, the person or persons to
                  whom the Grantee's rights are transferred by will or the laws
                  of descent and distribution shall have a period of three years
                  from the date of termination of the Grantee's employment or
                  service to exercise the Option which could have been exercised
                  during such period, subject to exercise during the remaining
                  term of the Option, subject to exercise during the remaining
                  term of the Option; and

                  (d) In the event of death of the Grantee while employed, the
                  Option shall become fully and immediately exercisable and may
                  be exercised by the person or persons to whom the Grantee's
                  rights are transferred by will or the laws of descent and
                  distribution for a period of three years after the Grantee's
                  death, subject to exercise during the remaining term of the
                  Option;

         5.3      Any determination made by the Committee with respect to any
                  matter referred to in this Section 5 shall be final and
                  conclusive on all persons affected thereby. Employment by, or
                  service to, the Company shall be deemed to include employment
                  by, or service to, any subsidiary of the Company by the
                  Grantee.

                                    SECTION 6
                              ADJUSTMENTS TO OPTION

         6.1      Subject to any required action by the Committee and
                  shareholders, the number of shares provided for in the Option,
                  the price per share thereof and the number of shares provided
                  for in the Plan shall be proportionately adjusted for any
                  increase or


                                       -4-
<PAGE>   5



                  decrease in the number of issued shares of the Company
                  resulting from the payment of a share dividend, a share split
                  or any transaction which is a "corporate transaction" (as
                  defined in the Treasury regulations promulgated under Section
                  424 of the Code).

         6.2      Subject to any required action by the Committee and
                  shareholders, if the Company shall be the surviving entity in
                  any merger or consolidation, or after a consolidation of the
                  Company and one or more entities in which the resulting entity
                  is an independent entity, the Option shall pertain to and
                  apply to the securities of the surviving entity in an amount
                  that the board of directors of the surviving entity, at its
                  sole discretion, determines to be equivalent, as nearly as
                  practicable, to the nearest whole number and class of shares
                  that were subject to the Option. These shares of stock or
                  other securities shall, after such merger or consolidation, be
                  deemed to be shares for all purposes of the Plan. The
                  aforesaid adjustments, when applicable, shall be made by the
                  Committee, and the Committee's determination shall be final,
                  binding and conclusive. Any such adjustment in the shares or
                  other securities subject to the ISO (including any adjustment
                  in the Exercise Price) shall be made in such manner as not to
                  constitute a modification as defined by Section 424(h) (3) of
                  the Code and only to the extent permitted by Sections 422 and
                  424 of the Code.

         6.3      In the event of a Change of Control (as defined below), any
                  and all outstanding Options not fully vested shall
                  automatically vest in full and shall be immediately
                  exercisable. The date on which such accelerated vesting and
                  immediate exercisability shall occur shall be the date of the
                  occurrence of the Change of Control.

                  A "Change of Control" shall be deemed to have taken place upon
                  (i) the acquisition by a third person, including a "group" as
                  defined in Section 13(d)(3) of the Securities Exchange Act of
                  1934, as amended, of shares of the Company having 50% or more
                  of the total number of votes that may be cast for the election
                  of Directors of the Company; (ii) shareholder approval of a
                  transaction for the acquisition of the Company, or
                  substantially all of its assets by another entity or for a
                  merger, reorganization, consolidation or other business
                  combination to which the Company is a part; or (iii) the
                  election during any period of 24 months or less of 50% or more
                  of the Directors of the Company where such Directors were not
                  in office immediately prior to such period provided, however,
                  that no "Change of Control" shall be deemed to have taken
                  place if the Directors of the Company in office on the date of
                  adoption of the Plan, or their successors in office nominated
                  by such Directors, affirmatively approve a resolution to such
                  effect.

                  Except as provided with respect to a Grantee in his or her
                  stock option agreement or other controlling agreement between
                  him or her and the Company, to the extent that the
                  acceleration, exercisability or parachute payment attributable
                  to the Option

                                       -5-
<PAGE>   6



                  following a Change of Control would result in "excess
                  parachute payments"(1) when the former are aggregated with
                  other payments or benefits to the Grantee (whether or not
                  payable by the Plan), such parachute payments or benefits
                  provided to a Grantee under this Agreement shall be reduced to
                  the extent necessary so that no portion thereof shall be
                  subject to the excise tax imposed by Section 4999 of the Code.
                  This reduction will only be made if it will cause the
                  Grantee's net after-tax benefit to exceed the net after-tax
                  benefit that would have existed if such reduction were not
                  made. "Net after-tax benefit" shall be the sum of (i) all
                  payments and benefits which a Grantee receives or is entitled
                  to receive that would constitute a "parachute payment" under
                  Section 280G of the Code, less (ii) the amount of federal
                  income taxes payable with respect to the payments and benefits
                  described in (i) above, calculated at the maximum marginal
                  income tax rate(2) for the year in which such payments and
                  benefits shall be paid to the Grantee, less (iii) the amount
                  of excise taxes imposed with respect to the payments and
                  benefits described in (i) above by Section 4999 of the Code.

         6.4      In the event of a change in the Company's shares which is
                  limited to a change of all of its authorized shares with par
                  value into the same number of shares with a different par
                  value or without par value, the shares resulting from any such
                  change shall be deemed to be shares within the meaning of the
                  Plan.

         6.5      Except as herein before expressly provided in Paragraphs 6.1,
                  6.2, 6.3 and 6.4 of this Section 6, the Grantee shall have no
                  rights by reason of any subdivision or consolidation of shares
                  of any class or payment of any share dividend or any other
                  increase or decrease in the number of shares of any class or
                  by reason of any dissolution, liquidation, merger,
                  consolidation or spin-off of assets or stock of another
                  corporation and any issuance by the Company of shares of any
                  class, or securities convertible into shares of any class,
                  shall not affect the Option, and no adjustment by reason
                  thereof shall be made with respect to the number or price of
                  the Company's shares subject to the Option. The grant of the
                  Option shall not affect in any way the right or power of the
                  Company to make adjustments, reclassifications,
                  reorganizations or changes of its capital or business
                  structure or to merge, consolidate, dissolve, liquidate, sell
                  or transfer all or any part of its business or assets.


- ----------------------
     (1)   "Excess parachute payments" are defined in Section 280G of the Code
           and are determined by tax counsel of the Company.

     (2)   "This rate is based on the rate for the year set forth in the Code at
           the time of the first payment to the participant.


                                       -6-
<PAGE>   7



                                    SECTION 7
                                    TRANSFER

         7.1      This Option shall not be transferable by the Grantee in any
                  way other than by will and the laws of descent and
                  distribution, except as may be otherwise permitted by written
                  agreement of the Company or securities regulatory authorities.
                  Any other attempted assignment, transfer, pledge,
                  hypothecation or other disposition of the Option shall be void
                  and have no effect unless in accordance with the terms set
                  forth herein.

                                    SECTION 8
                                WITHHOLDING TAXES

         8.1      The Company shall have the right to retain and withhold from
                  any payment, under the Option granted, any amount that is to
                  be withheld or otherwise deducted and paid with respect to
                  such payment. At its discretion, the Company may require the
                  Grantee, if he or she receives shares under a nonqualified
                  stock option grant, to reimburse the Company for any taxes
                  that are required to be withheld by the Company, and may
                  withhold any distribution in whole or in part until the
                  Company is so reimbursed. In lieu thereof, the Company shall
                  have the right to withhold from any other cash amounts due (or
                  to become due) to the Grantee an amount equal to such taxes
                  required to be withheld by the Company to reimburse the
                  Company for any such taxes, or the Company may retain and
                  withhold a number of shares of Common Stock having a market
                  value not less than the amount of such taxes and cancel (in
                  whole or in part) any shares of Common Stock so withheld in
                  order to reimburse the Company for any such taxes.

                                    SECTION 9
                            IMPACT ON OTHER BENEFITS

         9.1      The value of the Option (either on the date of grant of the
                  Option or at the time the shares are vested) shall not be
                  includable as compensation or earnings for purposes of any
                  other benefit plan offered by the Company.

                                   SECTION 10
                                 ADMINISTRATION

         10.1     The Committee shall have full authority and discretion
                  (subject only to the express provisions of the 1996 Omnibus
                  Plan, as amended) to decide all matters relating to the
                  administration and interpretation of the Plan and this
                  Agreement. All such Committee determinations shall be final,
                  conclusive and binding upon the Company, the Grantee and any
                  and all interested parties.


                                       -7-
<PAGE>   8





                                   SECTION 11
                       AGREEMENT TO CONTINUE IN EMPLOYMENT
                           OR SERVICE AS A CONSULTANT

         11.1     The vesting of this Option is earned only by continuing
                  service to the Company at the will of the Company and not
                  through the act of being hired, being granted this Option, or
                  acquiring shares hereunder. Nothing in the Plan or this
                  Agreement shall confer on a Grantee any right to continue in
                  the employ of the Company or in the service of the Company as
                  a consultant or interfere in any way with the right of the
                  Company to terminate his or her employment or consultantship
                  at any time.

                                   SECTION 12
                                  AMENDMENT(S)

         12.1     This Agreement shall be subject to the terms of the Plan as
                  amended except that the Option that is the subject of this
                  Agreement may not in any way be amended or terminated without
                  the Grantee's written consent.

                                   SECTION 13
                                FORCE AND EFFECT

         13.1     The various provisions of this Agreement are severable in
                  their entirety. Any determination of invalidity or
                  unenforceability of any one provision shall have no effect on
                  the continuing force and effect of the remaining provisions.

                                   SECTION 14
                         NOTICE OF DISPOSITION OF SHARES

         14.1     The Grantee agrees that if he or she should dispose of any
                  shares of Common Stock acquired on the exercise of the Option,
                  including a disposition by sale, exchange, gift or transfer of
                  legal title within six months of the date such shares are
                  transferred to the Grantee, the Grantee will notify the
                  Company promptly of such disposition.

                                   SECTION 15
                                     NOTICES

         15.1     All notices which may be or are required to be given by one
                  party to the other party pursuant to this Agreement shall be
                  in writing and shall be mailed by first class or certified
                  mail, return receipt requested, postage prepaid, or
                  transmitted by hand delivery as follows:


                                       -8-
<PAGE>   9


<TABLE>

                  <S>                      <C>
                  If to the Company:        DUSA Pharmaceuticals, Inc.
                                            181 University Avenue
                                            Suite 1208
                                            Toronto, ON M5H 3M7
                                            CANADA

                                            Attention:  Dr. D. Geoffrey Shulman

                  If to the Grantee:

                                            at the address of the Grantee from
                                            time to time in the records of the
                                            Company,
</TABLE>

                  or such other address as to which either party may from time
                  to time notify the other as aforesaid.

                                   SECTION 16
                            RESTRICTIONS ON TRANSFER

         16.1     The Grantee understands and acknowledges that he is subject to
                  certain restrictions on transfer under the Securities Act of
                  1933 of the United States, as amended, (the "1933 Act") of the
                  shares issued pursuant to the exercise of the Option; such
                  restrictions provide that the shares may not be sold without
                  registration or exemption from registration under the 1933
                  Act; and, for purposes of the Securities Act (Ontario) (the
                  "Ontario Act"), the first trade of such shares, other than a
                  trade exempted by the Ontario Act, will be a distribution
                  unless the Company has been a reporting issuer for at least
                  twelve (12) months and the Company is not in default of any
                  requirement of the Ontario Act, disclosure has been made to
                  the Ontario Securities Commission of the exempt trade, no
                  unusual effort is made to prepare the market or create a
                  demand for the shares, and no extraordinary commission or
                  consideration is paid with respect to the trade, provided that
                  such first trade is not from the holdings of a so-called
                  "control block".

                                   SECTION 17
                             REPORTING REQUIREMENTS

         17.1     The Grantee understands and acknowledges that he may be
                  subject to certain reporting requirements upon his receipt and
                  exercise of the Option, and in connection therewith, upon the
                  receipt and exercise of the Option, the Grantee agrees to
                  timely file with the Securities and Exchange Commission, the
                  National Association of Securities Dealers, Inc., and any
                  appropriate Canadian securities regulatory authorities, the
                  appropriate documentation regarding his ownership of the
                  Company's securities.


                                       -9-
<PAGE>   10





                                   SECTION 18
                                  GOVERNING LAW

         18.1     This Agreement shall be construed and enforced in accordance
                  with and governed by the laws of the State of New Jersey.

         IN WITNESS WHEREOF, this Agreement has been duly executed by the
parties hereto.
<TABLE>
<S>                                        <C>
Attest:                                    DUSA PHARMACEUTICALS, INC.,
                                           a New Jersey Corporation

                                           By
- --------------------------------             -----------------------------------
Nanette W. Mantell, Secretary              Dr. D. Geoffrey Shulman, President

                                           GRANTEE

                                            ---------------------

</TABLE>

                                       -10-
<PAGE>   11





                                   SCHEDULE A
                                SUBSCRIPTION FORM

To:      The Secretary of DUSA Pharmaceuticals, Inc.

         Pursuant to the terms and subject to the conditions set forth in the
Incentive Stock Option Agreement (the "Agreement") dated               , between
DUSA Pharmaceuticals, Inc. and the undersigned, and the Option granted to the
undersigned by such Agreement, I hereby elect to purchase                 shares
of Common Stock of DUSA Pharmaceuticals, Inc. which were the subject of such
Option. I understand that such purchase is subject to all the terms and
conditions of the Agreement. I request that the certificates for such shares of
Common Stock shall be issued in the name of:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

         The undersigned hereby represents and warrants to, and agrees with the
Company as follows:

         (a) The shares are being purchased for the undersigned's own account,
for investment purposes only, and not for the account of any other person, and
not with a view to distribution, assignment, or resale to others, or to
fractionalization in whole or in part and that the offering and sale of the
shares is intended to be exempt from registration under the Securities Act of
1933 (the "Act"). In furtherance thereof, the undersigned represents, warrants
and agrees as follows: (i) no other person has or will have a direct or indirect
beneficial interest in such shares and the undersigned will not sell,
hypothecate, or otherwise transfer his shares except in accordance with the Act
and applicable state securities laws or unless in the opinion of counsel for the
Company, an exemption from the registration requirements of the Act and such
laws is available; and (ii) the Company is under no obligation to register the
shares on behalf of the undersigned or to assist the undersigned in complying
with any exemption from registration.


<PAGE>   12




         (b) The undersigned has such knowledge and experience in financial and
business matters that the undersigned is capable of evaluating the merits and
risks of investment in the Company and of making an informed investment
decision.

         In full payment of the purchase price with respect to the Option
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian or
United States currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                      X
                              -------------------------------------
                                              (Signature)

                                     -------------------------------------
                                              Name (Please Print)

                                     -------------------------------------
                                              (Address)

                                     -------------------------------------
                                              Taxpayer Identification Number


                                      -12-

<PAGE>   1

                                                                    Exhibit 99.5

                       NONQUALIFIED STOCK OPTION AGREEMENT
       UNDER THE DUSA PHARMACEUTICALS, INC. 1996 OMNIBUS PLAN, AS AMENDED

         THIS AGREEMENT made as of the  th day of  , by and between DUSA
Pharmaceuticals, Inc., a corporation incorporated under the laws of the State of
New Jersey (the "Company"), and  , an individual residing in the State   (the
"Grantee").

         WHEREAS, pursuant to the DUSA Pharmaceuticals, Inc. 1996 Omnibus Plan,
as amended (the "Plan"), the Company has determined that its interests will be
advanced by providing an incentive to the Grantee to acquire a proprietary
interest in the Company and, as a shareholder, to share in its success, with
added incentive to work effectively for and in the Company's interest;

         NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, the parties hereby agree as follows:

                                   SECTION 1
                                      GRANT

1.1               The Company hereby grants to the Grantee, as a matter of
                  separate agreement and not in lieu of salary or any other
                  compensation for services, the right and option (the "Option")
                  to purchase, in accordance with the vesting rights outlined in
                  Sections 3.1 and 3.6 hereof, up to   shares of authorized but
                  unissued Common Stock, without par value ("Common Stock"), of
                  the Company on the terms and conditions herein set forth in
                  this Agreement.

                                   SECTION 2
                                      PRICE

2.1               The exercise price of the shares of Common Stock subject to
                  this Option shall be determined on the day of the grant based
                  upon the fair market value of the shares of Common Stock on
                  such date (i.e., $  per share) and calculated by increasing
                  such fair market value price by ten percent (10%) per year for
                  four (4) years, rounded to the nearest cent (the "Exercise
                  Price").

                                   SECTION 3
                                WHEN EXERCISABLE

3.1               This Option shall vest in the Grantee, and become exercisable,
                  as to twenty-five percent (25%) of the shares on the first
                  anniversary of the date of the grant, and an additional
                  twenty-five percent (25%) of the shares with respect to which
                  the Option has been granted on and after each of the three (3)
                  succeeding anniversaries of said date. Installments or
                  portions vested and not exercised in earlier periods shall be
                  accumulated and be available for exercise in later periods at
                  the then applicable Exercise Price as follows:


<PAGE>   2

                  3.1.1    up to twenty-five percent (25%) of the shares may be
                           exercised on or after the first anniversary of the
                           date of the grant, being  at an Exercise Price of $ ;

                  3.1.2    up to fifty percent (50%) of the shares may be
                           exercised on or after the second anniversary of the
                           date of the grant, being  at an Exercise Price of $ ;

                  3.1.3    up to seventy-five percent (75%) of the shares may be
                           exercised on or after the second anniversary of the
                           date of the grant, being  at an Exercise Price of $ ;
                           and

                  3.1.4    up to one hundred percent (100%) of the shares may be
                           exercised on or after the second anniversary of the
                           date of the grant, being  at an Exercise Price of $ ;

                  and, except as provided by Sections 3.6 and 6.3 hereof, the
                  Grantee shall only be entitled to exercise this Option, in
                  whole or in part, in the amounts and at the Exercise Price set
                  out above and from and after the dates so specified.

3.2               Subject to Sections 3.1 and 3.6 hereof, the Grantee shall have
                  the right, at any time prior to 5:00 p.m. (Eastern Standard
                  Time) on the date prior to the tenth anniversary date hereof,
                  being  , provided that if such day is not a day on which the
                  Company is open for business then on the first following day
                  on which the Company is open for business, to exercise this
                  Option for any number of the Optioned Shares up to the maximum
                  number of shares specified in Section 1.1 above.

3.3               No less than one thousand (1,000) shares may be purchased upon
                  any one exercise of the Option granted hereby unless the
                  number of shares purchased at such time is the total number of
                  shares in respect of which the Option hereby granted is then
                  exercisable.

3.4               In no event shall any Option granted hereby be exercisable for
                  a fractional share.

3.5               From time to time, in its discretion, the Committee may offer
                  the Grantee the right to cancel any Option granted hereunder
                  in exchange for such consideration as the Committee shall
                  determine.

3.6               Notwithstanding anything contained in Sections 1 and 3.1
                  hereof, the Option shall continue to vest in the Grantee only
                  so long as the Grantee shall continue to serve the Company.
                  Should the Grantee cease to serve in all such capacities, the
                  Option shall not further vest or become exercisable, and the
                  provisions of Section 5.2 shall apply with respect to the
                  exercise of the Option which has already vested in the Grantee
                  and has not yet been exercised. The Board of Directors shall
                  be entitled to determine if and when employment or service to
                  the Company has ceased with respect to the Grantee.

                                   SECTION 4
                                 HOW EXERCISABLE


                                       -2-
<PAGE>   3

4.1               Subject to such administrative regulations as the Committee
                  may from time to time adopt, the Grantee or beneficiary shall,
                  in order to exercise this Option give to the Company at its
                  principal office notice in writing in the form of Schedule A
                  hereto setting out the number of Optioned Shares with respect
                  to which the Option is being exercised. The notice must be
                  accompanied by payment of a certified check, official bank
                  cashier's check or money order in an amount equal to the
                  Exercise Price multiplied by the number of shares requested
                  and a duly executed copy of this Agreement.

4.2               Any notice under this Section shall include an undertaking to
                  furnish or execute such documents as the Committee in its
                  discretion shall deem necessary (i) to evidence such exercise,
                  in whole or in part, of the Option evidenced by this
                  Agreement, (ii) to determine whether registration is then
                  required under the Securities Act of 1933, or any other law,
                  as then in effect, and (iii) to comply with or satisfy the
                  requirements of the Securities Act of 1933, or any other law,
                  as then in effect.

4.3               The Grantee agrees that all shares purchased by him or her
                  under the Option will be acquired for investment, not
                  distribution, and that any notice of exercise of the Option
                  must be accompanied by a written representation to that
                  effect, signed by the Grantee.

                                   SECTION 5
                              TERMINATION OF OPTION

5.1               The Option granted hereby shall terminate and be of no force
                  or effect upon the expiration of ten years from the date of
                  the Grant unless terminated prior to such time as provided
                  below.

5.2               Subject to Section 3.6 hereof, should the Grantee cease to
                  serve the Company, the Grantee's Option shall be exercised as
                  follows:

                  5.2.1    If the Grantee's termination of employment or service
                           is other than for cause, or for the reasons provided
                           in subsections (b) - (d) below, the Option may be
                           exercised, to the extent exercisable, for a period of
                           three months after the date of such termination of
                           employment;

                  5.2.2    If the Grantee's termination of employment or service
                           is by reason of retirement or disability, the Option
                           may be exercised, to the extent exercisable, for a
                           period of 12 months after the date of such
                           termination;

                  5.2.3    In the event of death of the Grantee after
                           termination of employment or service pursuant to (a)
                           or (b) above, the person or persons to whom the
                           Grantee's rights are transferred by will or the laws
                           of descent and distribution shall have a period of
                           three years from the date of termination of the
                           Grantee's employment or service to exercise the
                           Option which could have been exercised during such
                           period; and

                  5.2.4    In the event of death of the Grantee while employed,
                           the Option shall become fully and immediately
                           exercisable and may be exercised by the person or


                                       -3-
<PAGE>   4




                           persons to whom the Grantee's rights are transferred
                           by will or the laws of descent and distribution for a
                           period of three years after the Grantee's death,
                           subject to exercise during the remaining term of the
                           Option;

5.3               Any determination made by the Committee with respect to any
                  matter referred to in this Section 5 shall be final and
                  conclusive on all persons affected thereby. Employment by, or
                  service to, the Company shall be deemed to include employment
                  by, or service to, any subsidiary of the Company by the
                  Grantee.

                                   SECTION 6
                              ADJUSTMENTS TO OPTION

6.1               Subject to any required action by the Committee and the
                  Company's shareholders, the number of shares provided for in
                  the Option, the price per share thereof and the number of
                  shares provided for in the Plan shall be proportionately
                  adjusted for any increase or decrease in the number of issued
                  shares of the Company resulting from the payment of a share
                  dividend, a share split or any transaction which is a
                  "corporate transaction" (as defined in the Treasury
                  regulations promulgated under Section 424 of the Code.

 6.2              Subject to any required action by the Committee and the
                  Company's shareholders, if the Company shall be the surviving
                  entity in any merger or consolidation, or after a
                  consolidation of the Company and one or more entities in which
                  the resulting entity is an independent entity, the Option
                  shall pertain to and apply to the securities of the surviving
                  entity in an amount that the board of directors of the
                  surviving entity, at its sole discretion, determines to be
                  equivalent, as nearly as practicable, to the nearest whole
                  number and class of shares that were subject to the Option.
                  These shares of stock or other securities shall, after such
                  merger or consolidation, be deemed to be shares for all
                  purposes of the Plan. The aforesaid adjustments, when
                  applicable, shall be made by the Committee, and the
                  Committee's determination shall be final, binding and
                  conclusive.

6.3               In the event of a Change of Control (as defined below), any
                  and all outstanding Options not fully vested shall
                  automatically vest in full and shall be immediately
                  exercisable. The date on which such accelerated vesting and
                  immediate exercisability shall occur shall be the date of the
                  occurrence of the Change of Control.

                  A "Change of Control" shall be deemed to have taken place upon
                  (i) the acquisition by a third person, including a "group" as
                  defined in Section 13(d)(3) of the Securities Exchange Act of
                  1934, as amended, of shares of the Company having 50% or more
                  of the total number of votes that may be cast for the election
                  of Directors of the Company; (ii) shareholder approval of a
                  transaction for the acquisition of the Company, or
                  substantially all of its assets by another entity or for a
                  merger, reorganization, consolidation or other business
                  combination to which the Company is a part; or (iii) the
                  election during any period of 24 months or less of 50% or more
                  of the Directors of the Company where such Directors were not
                  in office immediately prior to such period provided, however,
                  that no "Change of Control" shall be deemed to have taken
                  place if the Directors of the Company in office on the date of
                  adoption


                                       -4-
<PAGE>   5



                  of the Plan, or their successors in office nominated by such
                  Directors, affirmatively approve a resolution to such effect.

                  Except as provided with respect to a Grantee in his or her
                  stock option agreement or other controlling agreement between
                  him or her and the Company, to the extent that the
                  acceleration, exercisability or parachute payment attributable
                  to the Option following a Change of Control would result in
                  "excess parachute payments"(1) when the former are aggregated
                  with other payments or benefits to the Grantee (whether or not
                  payable by the Plan), such parachute payments or benefits
                  provided to a Grantee under this Agreement shall be reduced to
                  the extent necessary so that no portion thereof shall be
                  subject to the excise tax imposed by Section 4999 of the Code.
                  This reduction will only be made if it will cause the
                  Grantee's net after-tax benefit to exceed the net after-tax
                  benefit that would have existed if such reduction were not
                  made. "Net after-tax benefit" shall be the sum of (i) all
                  payments and benefits which a Grantee receives or is entitled
                  to receive that would constitute a "parachute payment" under
                  Section 280G of the Code, less (ii) the amount of federal
                  income taxes payable with respect to the payments and benefits
                  described in (i) above, calculated at the maximum marginal
                  income tax rate(2) for the year in which such payments and
                  benefits shall be paid to the Grantee, less (iii) the amount
                  of excise taxes imposed with respect to the payments and
                  benefits described in (i) above by Section 4999 of the Code.

6.4               In the event of a change in the Company's shares which is
                  limited to a change of all of its authorized shares with par
                  value into the same number of shares with a different par
                  value or without par value, the shares resulting from any such
                  change shall be deemed to be shares within the meaning of the
                  Plan.

6.5               Except as herein before expressly provided in Paragraphs 6.1,
                  6.2, 6.3 and 6.4 of this Section 6, the Grantee shall have no
                  rights by reason of any subdivision or consolidation of shares
                  of any class or payment of any share dividend or any other
                  increase or decrease in the number of shares of any class or
                  by reason of any dissolution, liquidation, merger,
                  consolidation or spin-off of assets or stock of another
                  corporation and any issuance by the Company of shares of any
                  class, or securities convertible into shares of any class,
                  shall not affect the Option, and no adjustment by reason
                  thereof shall be made with respect to the number or price of
                  the Company's shares subject to the Option. The grant of the
                  Option shall not affect in any way the right or power of the
                  Company to make adjustments, reclassifications,
                  reorganizations or changes of its capital or business
                  structure or to merge, consolidate, dissolve, liquidate, sell
                  or transfer all or any part of its business or assets.

                                   SECTION 7
                                   TRANSFER

- ---------------
     (1)"Excess parachute payments" are defined in Section 280G of the Code and
are determined by tax counsel of the Company.

     (2)"This rate is based on the rate for the year set forth in the Code at
the time of the first payment to the participant.

                                      -5-
<PAGE>   6




7.1               This Option shall not be transferable by any individual
                  Grantee in any way other than by will and the laws of descent
                  and distribution. During the lifetime of any individual
                  Grantee, the Option shall be exercisable only by him or her.
                  Any other attempted assignment, transfer, pledge,
                  hypothecation or other disposition of the Option by any
                  Grantee shall be void and have no effect unless in accordance
                  with the terms set forth herein.

                                   SECTION 8
                                WITHHOLDING TAXES

8.1               The Company shall have the right to retain and withhold from
                  any payment, under the Option granted, any amount that is to
                  be withheld or otherwise deducted and paid with respect to
                  such payment. At its discretion, the Company may require the
                  Grantee, if he or she receives shares under a nonqualified
                  stock option grant, to reimburse the Company for any taxes
                  that are required to be withheld by the Company, and may
                  withhold any distribution in whole or in part until the
                  Company is so reimbursed. In lieu thereof, the Company shall
                  have the right to withhold from any other cash amounts due (or
                  to become due) to the Grantee an amount equal to such taxes
                  required to be withheld by the Company to reimburse the
                  Company for any such taxes, or the Company may retain and
                  withhold a number of shares of Common Stock having a market
                  value not less than the amount of such taxes and cancel (in
                  whole or in part) any shares of Common Stock so withheld in
                  order to reimburse the Company for any such taxes.

                                   SECTION 9
                            IMPACT ON OTHER BENEFITS

9.1               The value of the Option (either on the date of grant of the
                  Option or at the time the shares are vested) shall not be
                  includable as compensation or earnings for purposes of any
                  other benefit plan offered by the Company.

                                   SECTION 10
                                 ADMINISTRATION

10.1              The Committee shall have full authority and discretion
                  (subject only to the express provisions of the 1996 Omnibus
                  Plan, as amended) to decide all matters relating to the
                  administration and interpretation of the Plan and this
                  Agreement. All such Committee determinations shall be final,
                  conclusive and binding upon the Company, the Grantee and any
                  and all interested parties.

                                   SECTION 11
                       AGREEMENT TO CONTINUE IN EMPLOYMENT
                           OR SERVICE AS A CONSULTANT

11.1              Nothing in the Plan or this Agreement shall confer on a
                  Grantee any right to continue in the employ of the Company or
                  in the service of the Company as a consultant or interfere in
                  any way with the right of the Company to terminate his or her
                  employment or consultantship at any time.


                                       -6-
<PAGE>   7




                                       -7-
<PAGE>   8


                                   SECTION 12
                                  AMENDMENT(S)

12.1              This Agreement shall be subject to the terms of the Plan as
                  amended except that the Option that is the subject of this
                  Agreement may not in any way be amended or terminated without
                  the Grantee's written consent.

                                   SECTION 13
                                FORCE AND EFFECT

13.1              The various provisions of this Agreement are severable in
                  their entirety. Any determination of invalidity or
                  unenforceability of any one provision shall have no effect on
                  the continuing force and effect of the remaining provisions.

                                   SECTION 14
                         NOTICE OF DISPOSITION OF SHARES

14.1              The Grantee agrees that if it, he or she should dispose of any
                  shares of Common Stock acquired on the exercise of the Option,
                  including a disposition by sale, exchange, gift or transfer of
                  legal title within six months of the date such shares are
                  transferred to the Grantee, the Grantee will notify the
                  Company promptly of such disposition.

                                   SECTION 15
                                     NOTICES

15.1              All notices which may be or are required to be given by one
                  party to the other party pursuant to this Agreement shall be
                  in writing and shall be mailed by first class or certified
                  mail, return receipt requested, postage prepaid, or
                  transmitted by hand delivery as follows:
<TABLE>
                  <S>                      <C>
                  If to the Company:        DUSA Pharmaceuticals, Inc.
                                            181 University Avenue, Suite 1208
                                            Toronto, ON M5H 3M7

                                            CANADA

                                            Attention:  Dr. D. Geoffrey Shulman

                  If to the Grantee:

                                            at the address of the Grantee from
                                            time to time in the records of the
                                            Company,
</TABLE>

                  or such other address as to which either party may from time
                  to time notify the other as aforesaid.


                                       -8-
<PAGE>   9





                                   SECTION 16
                            RESTRICTIONS ON TRANSFER

16.1              The Grantee understands and acknowledges that it, he or she is
                  subject to certain restrictions on transfer under the
                  Securities Act of 1933 of the United States, as amended, (the
                  "1933 Act") of the shares issued pursuant to the exercise of
                  the Option; such restrictions provide that the shares may not
                  be sold without registration or exemption from registration
                  under the 1933 Act; and, for purposes of the Securities Act
                  (Ontario) (the "Ontario Act"), the first trade of such shares,
                  other than a trade exempted by the Ontario Act, will be a
                  distribution unless the Company has been a reporting issuer
                  for at least twelve (12) months and the Company is not in
                  default of any requirement of the Ontario Act, disclosure has
                  been made to the Ontario Securities Commission of the exempt
                  trade, no unusual effort is made to prepare the market or
                  create a demand for the shares, and no extraordinary
                  commission or consideration is paid with respect to the trade,
                  provided that such first trade is not from the holdings of a
                  so-called "control block".

                                   SECTION 17
                             REPORTING REQUIREMENTS

17.1              The Grantee understands and acknowledges that it, he or she
                  may be subject to certain reporting requirements upon his
                  receipt and exercise of the Option, and in connection
                  therewith, upon the receipt and exercise of the Option, the
                  Grantee agrees to timely file with the Securities and Exchange
                  Commission, the National Association of Securities Dealers,
                  Inc., and any appropriate Canadian securities regulatory
                  authorities, the appropriate documentation regarding his
                  ownership of the Company's securities.

                                   SECTION 18
                                  GOVERNING LAW

18.1              This Agreement shall be construed and enforced in accordance
                  with and governed by the laws of the State of New Jersey.

         IN WITNESS WHEREOF, this Agreement has been duly executed by the
parties hereto.

Attest:                                     DUSA PHARMACEUTICALS, INC.,
                                            a New Jersey corporation

                                            By:
- ----------------------------------             ---------------------------
Nanette W, Mantell, Secretary                  Ronald L. Carroll,
                                               Executive Vice President

                                            GRANTEE

                                             -------------------------------



                                       -9-
<PAGE>   10




                                       -10-
<PAGE>   11

                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:      The Secretary of DUSA Pharmaceuticals, Inc.

         Pursuant to the terms and subject to the conditions set forth in the
Nonqualified Stock Option Agreement (the "Agreement") dated  , between DUSA
Pharmaceuticals, Inc. and the undersigned, and the Option granted to the
undersigned by such Agreement, I hereby elect to purchase_______________________
shares of Common Stock of DUSA Pharmaceuticals, Inc. which were the subject of
such Option. I understand that such purchase is subject to all the terms and
conditions of the Agreement. I request that the certificates for such shares of
Common Stock shall be issued in the name of:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

         The undersigned hereby represents and warrants to, and agrees with the
Company as follows:

         (a) The shares are being purchased for the undersigned's own account,
for investment purposes only, and not for the account of any other person, and
not with a view to distribution, assignment, or resale to others, or to
fractionalization in whole or in part and that the offering and sale of the
shares is intended to be exempt from registration under the Securities Act of
1933 (the "Act"). In furtherance thereof, the undersigned represents, warrants
and agrees as follows: (i) no other person has or will have a direct or indirect
beneficial interest in such shares and the undersigned will not sell,
hypothecate, or otherwise transfer his shares except in accordance with the Act
and applicable state securities laws or unless in the opinion of counsel for the
Company, an exemption from the registration requirements of the Act and such
laws is available; and (ii) the Company is under no obligation to register the
shares on behalf of the undersigned or to assist the undersigned in complying
with any exemption from registration.

         (b) The undersigned has such knowledge and experience in financial and
business matters that the undersigned is capable of evaluating the merits and
risks of investment in the Company and of making an informed investment
decision.


<PAGE>   12



         In full payment of the purchase price with respect to the Option
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian or
United States currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                         X
                                ----------------------------------
                                                 (Signature)

                                        -------------------------------------
                                                 Name (Please Print)

                                        -------------------------------------
                                                 (Address)

                                        -------------------------------------
                                                 Taxpayer Identification Number


                                       -12-

<PAGE>   1

                                                                    Exhibit 99.6

                        INCENTIVE STOCK OPTION AGREEMENT
       UNDER THE DUSA PHARMACEUTICALS, INC. 1996 OMNIBUS PLAN, AS AMENDED

         THIS AGREEMENT made as of the  th day of  , by and between DUSA
Pharmaceuticals, Inc., a corporation incorporated under the laws of the State of
New Jersey (the "Company"), and  , (the "Grantee").

         WHEREAS, pursuant to the DUSA Pharmaceuticals, Inc. 1996 Omnibus Plan,
as amended (the "Plan"), the Company has determined that its interests will be
advanced by providing an incentive to the Grantee to acquire a proprietary
interest in the Company and, as a shareholder, to share in its success, with
added incentive to work effectively for and in the Company's interest;

         NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, the parties hereby agree as follows:

                                   SECTION 1

                                      GRANT

1.1               The Company hereby grants to the Grantee, as a matter of
                  separate agreement and not in lieu of salary or any other
                  compensation for services, the right and option (the "Option")
                  to purchase, in accordance with the vesting rights outlined in
                  Sections 3.1 and 3.6 hereof, up to   shares of authorized but
                  unissued Common Stock, without par value ("Common Stock"), of
                  the Company on the terms and conditions herein set forth in
                  this Agreement.

                                   SECTION 2
                                      PRICE

2.1               The exercise price of the shares of Common Stock subject to
                  this Option shall be determined on the day of the grant based
                  upon the fair market value of the shares of Common Stock on
                  such date (i.e., $   per share) and calculated by increasing
                  such fair market value price by ten percent (10%) per year for
                  four (4) years, rounded to the nearest cent (the "Exercise
                  Price").

                                   SECTION 3
                                WHEN EXERCISABLE

3.1               This Option shall vest in the Grantee, and become exercisable,
                  as to twenty-five percent (25%) of the shares on the first
                  anniversary of the date of the grant, and an



<PAGE>   2



                  additional twenty-five percent (25%) of the shares with
                  respect to which the Option has been granted on and after each
                  of the three (3) succeeding anniversaries of said date.
                  Installments or portions vested and not exercised in earlier
                  periods shall be accumulated and be available for exercise in
                  later periods at the then applicable Exercise Price as
                  follows:

                  3.1.1    up to twenty-five percent (25%) of the shares may be
                           exercised on or after the first anniversary of the
                           date of the grant, being  at an Exercise Price of $ ;

                  3.1.2    up to fifty percent (50%) of the shares may be
                           exercised on or after the second anniversary of the
                           date of the grant, being  at an Exercise Price of $ ;

                  3.1.3    up to seventy-five percent (75%) of the shares may be
                           exercised on or after the second anniversary of the
                           date of the grant, being  at an Exercise Price of $ ;
                           and

                  3.1.4    up to one hundred percent (100%) of the shares may be
                           exercised on or after the second anniversary of the
                           date of the grant, being  at an Exercise Price of $ ;

                  and, except as provided by Sections 3.6 and 6.3 hereof, the
                  Grantee shall only be entitled to exercise this Option, in
                  whole or in part, in the amounts, at the Exercise Price, set
                  out above and from and after the dates so specified.

3.2               Subject to Sections 3.1 and 3.6 hereof, the Grantee shall have
                  the right, at any time prior to 5:00 p.m. (Eastern Standard
                  Time) on the date prior to the tenth anniversary date hereof,
                   , provided that if such day is not a day on which the Company
                  is open for business then on the first following day on which
                  the Company is open for business, to exercise this Option for
                  any number of the Optioned Shares up to the maximum number of
                  shares specified in Section 1.1 above.

3.3               No less than one thousand (1,000) shares may be purchased upon
                  any one exercise of the Option granted hereby unless the
                  number of shares purchased at such time is the total number of
                  shares in respect of which the Option hereby granted is then
                  exercisable.

3.4               In no event shall any Option granted hereby be exercisable for
                  a fractional share.

3.5               From time to time, in its discretion, the Committee may offer
                  the Grantee the right to cancel any Option granted hereunder
                  in exchange for such consideration as the Committee shall
                  determine.

3.6               Notwithstanding anything contained in Sections 1 and 3.1
                  hereof, the Option shall continue to vest in the Grantee only
                  so long as the Grantee shall continue to serve the


                                       -2-
<PAGE>   3



                  Company. Should the Grantee cease to serve the Company, the
                  provisions of Section 5.2 shall apply with respect to the
                  vesting and exercise of the Option. The Board of Directors
                  shall be entitled to determine if and when employment or
                  service to the Company has ceased with respect to the Grantee.

3.7               The Options shall be exercised in accordance with Section 422
                  of the Internal Revenue Code of regulations as amended. To the
                  extent that the exercise of the Option does not meet the
                  requirements of Section 422 as hereinafter amended, the Option
                  shall be considered a nonqualified stock option.

3.8               No Option may be exercised during a calendar year which would
                  result in the purchase of shares of the Company having an
                  aggregate fair market value (determined at the time of the
                  grant of the Option ) in excess of One Hundred Thousand
                  Dollars ($100,000.00) except and to the extent that such
                  Option was first exercisable in preceding calendar years.

                                   SECTION 4
                                 HOW EXERCISABLE

4.1               Subject to such administrative regulations as the Committee
                  may from time to time adopt, the Grantee or beneficiary shall,
                  in order to exercise this Option give to the Company at its
                  principal office notice in writing in the form of Schedule A
                  hereto setting out the number of Optioned Shares with respect
                  to which the Option is being exercised. The notice must be
                  accompanied by payment of a certified check, official bank
                  cashier's check or money order in an amount equal to the
                  Exercise Price multiplied by the number of shares requested
                  and a duly executed copy of this Agreement. At the discretion
                  of the Committee, the Grantee may pay all or a portion of the
                  purchase price by tender of Common Stock or a combination of
                  stock and cash or other means determined by the Committee.

4.2               Any notice under this Section shall include an undertaking to
                  furnish or execute such documents as the Committee in its
                  discretion shall deem necessary (i) to evidence such exercise,
                  in whole or in part, of the Option evidenced by this
                  Agreement, (ii) to determine whether registration is then
                  required under the Securities Act of 1933, or any other law,
                  as then in effect, and (iii) to comply with or satisfy the
                  requirements of the Securities Act of 1933, or any other law,
                  as then in effect.

4.3               The Grantee agrees that all shares purchased by him or her
                  under the Option will be acquired for investment, not
                  distribution, and that any notice of exercise of the Option
                  must be accompanied by a written representation to that
                  effect, signed by the Grantee.


                                       -3-
<PAGE>   4





                                   SECTION 5
                              TERMINATION OF OPTION

5.1               The Option granted hereby shall terminate and be of no force
                  or effect upon the expiration of ten years from the date of
                  the Grant unless terminated prior to such time as provided
                  below.

5.2               Subject to Section 3.6 hereof, should the Grantee cease to
                  serve the Company, the Grantee's Option shall be exercised as
                  follows:

                   5.2.1   If the Grantee's termination of service is other than
                           for cause, or for the reasons provided in subsections
                           (b) - (d) below, the Option may be exercised, to the
                           extent exercisable, for a period of three months
                           after the date of such termination of employment;

                   5.2.2   If the Grantee's termination of service is by reason
                           of retirement or disability, the Option may be
                           exercised, to the extent exercisable, for a period of
                           12 months after the date of such termination;

                   5.2.3   In the event of death of the Grantee after
                           termination of service pursuant to (a) or (b) above,
                           the person or persons to whom the Grantee's rights
                           are transferred by will or the laws of descent and
                           distribution shall have a period of three years from
                           the date of termination of the Grantee's employment
                           or service to exercise the Option which could have
                           been exercised during such period, subject to
                           exercise during the remaining term of the Option,
                           subject to exercise during the remaining term of the
                           Option; and

                   5.2.4   In the event of death of the Grantee while employed,
                           the Option shall become fully and immediately
                           exercisable and may be exercised by the person or
                           persons to whom the Grantee's rights are transferred
                           by will or the laws of descent and distribution for a
                           period of three years after the Grantee's death,
                           subject to exercise during the remaining term of the
                           Option;

5.3               Any determination made by the Committee with respect to any
                  matter referred to in this Section 5 shall be final and
                  conclusive on all persons affected thereby. Employment by, or
                  service to, the Company shall be deemed to include employment
                  by, or service to, any subsidiary of the Company by the
                  Grantee.

                                   SECTION 6
                              ADJUSTMENTS TO OPTION


6.1               Subject to any required action by the Committee and
                  shareholders, the number of shares provided for in the Option,
                  the price per share thereof and the number of



                                       -4-
<PAGE>   5



                  shares provided for in the Plan shall be proportionately
                  adjusted for any increase or decrease in the number of issued
                  shares of the Company resulting from the payment of a share
                  dividend, a share split or any transaction which is a
                  "corporate transaction" (as defined in the Treasury
                  regulations promulgated under Section 424 of the Code).

6.2               Subject to any required action by the Committee and
                  shareholders, if the Company shall be the surviving entity in
                  any merger or consolidation, or after a consolidation of the
                  Company and one or more entities in which the resulting entity
                  is an independent entity, the Option shall pertain to and
                  apply to the securities of the surviving entity in an amount
                  that the board of directors of the surviving entity, at its
                  sole discretion, determines to be equivalent, as nearly as
                  practicable, to the nearest whole number and class of shares
                  that were subject to the Option. These shares of stock or
                  other securities shall, after such merger or consolidation, be
                  deemed to be shares for all purposes of the Plan. The
                  aforesaid adjustments, when applicable, shall be made by the
                  Committee, and the Committee's determination shall be final,
                  binding and conclusive. Any such adjustment in the shares or
                  other securities subject to the ISO (including any adjustment
                  in the Exercise Price) shall be made in such manner as not to
                  constitute a modification as defined by Section 424(h) (3) of
                  the Code and only to the extent permitted by Sections 422 and
                  424 of the Code.

6.3               In the event of a Change of Control (as defined below), any
                  and all outstanding Options not fully vested shall
                  automatically vest in full and shall be immediately
                  exercisable. The date on which such accelerated vesting and
                  immediate exercisability shall occur shall be the date of the
                  occurrence of the Change of Control.

                  A "Change of Control" shall be deemed to have taken place upon
                  (i) the acquisition by a third person, including a "group" as
                  defined in Section 13(d)(3) of the Securities Exchange Act of
                  1934, as amended, of shares of the Company having 50% or more
                  of the total number of votes that may be cast for the election
                  of Directors of the Company; (ii) shareholder approval of a
                  transaction for the acquisition of the Company, or
                  substantially all of its assets by another entity or for a
                  merger, reorganization, consolidation or other business
                  combination to which the Company is a part; or (iii) the
                  election during any period of 24 months or less of 50% or more
                  of the Directors of the Company where such Directors were not
                  in office immediately prior to such period provided, however,
                  that no "Change of Control" shall be deemed to have taken
                  place if the Directors of the Company in office on the date of
                  adoption of the Plan, or their successors in office nominated
                  by such Directors, affirmatively approve a resolution to such
                  effect.

                  Except as provided with respect to a Grantee in his or her
                  stock option agreement or other controlling agreement between
                  him or her and the Company, to the extent that the
                  acceleration, exercisability or parachute payment attributable
                  to the Option

                                       -5-
<PAGE>   6


                  following a Change of Control would result in "excess
                  parachute payments"(1) when the former are aggregated with
                  other payments or benefits to the Grantee (whether or not
                  payable by the Plan), such parachute payments or benefits
                  provided to a Grantee under this Agreement shall be reduced to
                  the extent necessary so that no portion thereof shall be
                  subject to the excise tax imposed by Section 4999 of the Code.
                  This reduction will only be made if it will cause the
                  Grantee's net after-tax benefit to exceed the net after-tax
                  benefit that would have existed if such reduction were not
                  made. "Net after-tax benefit" shall be the sum of (i) all
                  payments and benefits which a Grantee receives or is entitled
                  to receive that would constitute a "parachute payment" under
                  Section 280G of the Code, less (ii) the amount of federal
                  income taxes payable with respect to the payments and benefits
                  described in (i) above, calculated at the maximum marginal
                  income tax rate(2) for the year in which such payments and
                  benefits shall be paid to the Grantee, less (iii) the amount
                  of excise taxes imposed with respect to the payments and
                  benefits described in (i) above by Section 4999 of the Code.

6.4               In the event of a change in the Company's shares which is
                  limited to a change of all of its authorized shares with par
                  value into the same number of shares with a different par
                  value or without par value, the shares resulting from any such
                  change shall be deemed to be shares within the meaning of the
                  Plan.

6.5               Except as herein before expressly provided in Paragraphs 6.1,
                  6.2, 6.3 and 6.4 of this Section 6, the Grantee shall have no
                  rights by reason of any subdivision or consolidation of shares
                  of any class or payment of any share dividend or any other
                  increase or decrease in the number of shares of any class or
                  by reason of any dissolution, liquidation, merger,
                  consolidation or spin-off of assets or stock of another
                  corporation and any issuance by the Company of shares of any
                  class, or securities convertible into shares of any class,
                  shall not affect the Option, and no adjustment by reason
                  thereof shall be made with respect to the number or price of
                  the Company's shares subject to the Option. The grant of the
                  Option shall not affect in any way the right or power of the
                  Company to make adjustments, reclassifications,
                  reorganizations or changes of its capital or business
                  structure or to merge, consolidate, dissolve, liquidate, sell
                  or transfer all or any part of its business or assets.



- -----------------
     (1)   "Excess parachute payments" are defined in Section 280G of the Code
           and are determined by tax counsel of the Company.

     (2)   "This rate is based on the rate for the year set forth in the Code at
           the time of the first payment to the participant.


                                       -6-
<PAGE>   7

                                   SECTION 7
                                    TRANSFER

7.1               This Option shall not be transferable by the Grantee in any
                  way other than by will and the laws of descent and
                  distribution, except as may be otherwise permitted by written
                  agreement of the Company or securities regulatory authorities.
                  Any other attempted assignment, transfer, pledge,
                  hypothecation or other disposition of the Option shall be void
                  and have no effect unless in accordance with the terms set
                  forth herein.

                                   SECTION 8
                                WITHHOLDING TAXES

8.1               The Company shall have the right to retain and withhold from
                  any payment, under the Option granted, any amount that is to
                  be withheld or otherwise deducted and paid with respect to
                  such payment. At its discretion, the Company may require the
                  Grantee, if he or she receives shares under a nonqualified
                  stock option grant, to reimburse the Company for any taxes
                  that are required to be withheld by the Company, and may
                  withhold any distribution in whole or in part until the
                  Company is so reimbursed. In lieu thereof, the Company shall
                  have the right to withhold from any other cash amounts due (or
                  to become due) to the Grantee an amount equal to such taxes
                  required to be withheld by the Company to reimburse the
                  Company for any such taxes, or the Company may retain and
                  withhold a number of shares of Common Stock having a market
                  value not less than the amount of such taxes and cancel (in
                  whole or in part) any shares of Common Stock so withheld in
                  order to reimburse the Company for any such taxes.

                                   SECTION 9
                            IMPACT ON OTHER BENEFITS

9.1               The value of the Option (either on the date of grant of the
                  Option or at the time the shares are vested) shall not be
                  includable as compensation or earnings for purposes of any
                  other benefit plan offered by the Company.

                                   SECTION 10
                                 ADMINISTRATION

10.1              The Committee shall have full authority and discretion
                  (subject only to the express provisions of the 1996 Omnibus
                  Plan, as amended) to decide all matters relating to the
                  administration and interpretation of the Plan and this
                  Agreement. All such Committee determinations shall be final,
                  conclusive and binding upon the Company, the Grantee and any
                  and all interested parties.


                                       -7-
<PAGE>   8





                                   SECTION 11
                       AGREEMENT TO CONTINUE IN EMPLOYMENT
                           OR SERVICE AS A CONSULTANT

11.1              The vesting of this Option is earned only by continuing
                  service to the Company at the will of the Company and not
                  through the act of being hired, being granted this Option, or
                  acquiring shares hereunder. Nothing in the Plan or this
                  Agreement shall confer on a Grantee any right to continue in
                  the employ of the Company or in the service of the Company as
                  a consultant or interfere in any way with the right of the
                  Company to terminate his or her employment or consultantship
                  at any time.

                                   SECTION 12
                                  AMENDMENT(S)

12.1              This Agreement shall be subject to the terms of the Plan as
                  amended except that the Option that is the subject of this
                  Agreement may not in any way be amended or terminated without
                  the Grantee's written consent.

                                   SECTION 13
                                FORCE AND EFFECT

13.1              The various provisions of this Agreement are severable in
                  their entirety. Any determination of invalidity or
                  unenforceability of any one provision shall have no effect on
                  the continuing force and effect of the remaining provisions.

                                   SECTION 14
                         NOTICE OF DISPOSITION OF SHARES

14.1              The Grantee agrees that if he or she should dispose of any
                  shares of Common Stock acquired on the exercise of the Option,
                  including a disposition by sale, exchange, gift or transfer of
                  legal title within six months of the date such shares are
                  transferred to the Grantee, the Grantee will notify the
                  Company promptly of such disposition.

                                   SECTION 15
                                     NOTICES

15.1              All notices which may be or are required to be given by one
                  party to the other party pursuant to this Agreement shall be
                  in writing and shall be mailed by first class or certified
                  mail, return receipt requested, postage prepaid, or
                  transmitted by hand delivery as follows:


                                       -8-
<PAGE>   9


<TABLE>

           <S>                      <C>
           If to the Company:        DUSA Pharmaceuticals, Inc.
                                     181 University Avenue, Suite 1208
                                     Toronto, ON M5H 3M7
                                     CANADA


                                     Attention:  Dr. D. Geoffrey Shulman

           If to the Grantee:

                                     at the address of the Grantee from time to
                                     time in the records of the Company,
</TABLE>

         or such other address as to which either party may from time
         to time notify the other as aforesaid.

                                   SECTION 16
                            RESTRICTIONS ON TRANSFER

16.1              The Grantee understands and acknowledges that he is subject to
                  certain restrictions on transfer under the Securities Act of
                  1933 of the United States, as amended, (the "1933 Act") of the
                  shares issued pursuant to the exercise of the Option; such
                  restrictions provide that the shares may not be sold without
                  registration or exemption from registration under the 1933
                  Act; and, for purposes of the Securities Act (Ontario) (the
                  "Ontario Act"), the first trade of such shares, other than a
                  trade exempted by the Ontario Act, will be a distribution
                  unless the Company has been a reporting issuer for at least
                  twelve (12) months and the Company is not in default of any
                  requirement of the Ontario Act, disclosure has been made to
                  the Ontario Securities Commission of the exempt trade, no
                  unusual effort is made to prepare the market or create a
                  demand for the shares, and no extraordinary commission or
                  consideration is paid with respect to the trade, provided that
                  such first trade is not from the holdings of a so-called
                  "control block".

                                   SECTION 17
                             REPORTING REQUIREMENTS

17.1              The Grantee understands and acknowledges that he may be
                  subject to certain reporting requirements upon his receipt and
                  exercise of the Option, and in connection therewith, upon the
                  receipt and exercise of the Option, the Grantee agrees to
                  timely file with the Securities and Exchange Commission, the
                  National Association of Securities Dealers, Inc., and any
                  appropriate Canadian securities regulatory authorities, the
                  appropriate documentation regarding his ownership of the
                  Company's securities.

                                       -9-
<PAGE>   10

                                   SECTION 18
                                  GOVERNING LAW

18.1     This Agreement shall be construed and enforced in accordance with and
         governed by the laws of the State of New Jersey.


         IN WITNESS WHEREOF, this Agreement has been duly executed by the
parties hereto.

Attest:                                      DUSA PHARMACEUTICALS, INC.,
                                             a New Jersey Corporation

                                             By:
- ----------------------------------              --------------------------------
Nanette W. Mantell, Secretary                D. Geoffrey Shulman, President

                                             GRANTEE

                                             By:
                                                --------------------------------


                                       -10-
<PAGE>   11





                                   SCHEDULE A

                                SUBSCRIPTION FORM

To:      The Secretary of DUSA Pharmaceuticals, Inc.

         Pursuant to the terms and subject to the conditions set forth in the
Nonqualified Stock Option Agreement (the "Agreement") dated  , between DUSA
Pharmaceuticals, Inc. and the undersigned, and the Option granted to the
undersigned by such Agreement, I hereby elect to purchase____________________
shares of Common Stock of DUSA Pharmaceuticals, Inc. which were the subject of
such Option. I understand that such purchase is subject to all the terms and
conditions of the Agreement. I request that the certificates for such shares of
Common Stock shall be issued in the name of:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

and be delivered to:

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
                     (please print or type name and address)

         The undersigned hereby represents and warrants to, and agrees with the
Company as follows:

         (a) The shares are being purchased for the undersigned's own account,
for investment purposes only, and not for the account of any other person, and
not with a view to distribution, assignment, or resale to others, or to
fractionalization in whole or in part and that the offering and sale of the
shares is intended to be exempt from registration under the Securities Act of
1933 (the "Act"). In furtherance thereof, the undersigned represents, warrants
and agrees as follows: (i) no other person has or will have a direct or indirect
beneficial interest in such shares and the undersigned will not sell,
hypothecate, or otherwise transfer his shares except in accordance with the Act
and applicable state securities laws or unless in the opinion of counsel for the
Company, an exemption from the registration requirements of the Act and such
laws is available; and (ii) the Company is under no obligation to register the
shares on behalf of the undersigned or to assist the undersigned in complying
with any exemption from registration.


<PAGE>   12


         (b) The undersigned has such knowledge and experience in financial and
business matters that the undersigned is capable of evaluating the merits and
risks of investment in the Company and of making an informed investment
decision.

         In full payment of the purchase price with respect to the Option
exercised, the undersigned hereby tenders payment of $___________ by certified
check or official bank cashier's check or money order payable in Canadian or
United States currency to the order of DUSA Pharmaceuticals, Inc.

Dated:                               X
                                       -----------------------------------
                                              (Signature)

                                     -------------------------------------
                                              Name (Please Print)

                                     -------------------------------------
                                              (Address)

                                     -------------------------------------
                                              Taxpayer Identification Number

                                       -12-


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