BIOTRANSPLANT INC
S-8, 1996-10-31
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1

              As filed with the Securities and Exchange Commission
                               on October 31, 1996
 
                                                      Registration No. 333-
===============================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                           BIOTRANSPLANT INCORPORATED
             (Exact name of registrant as specified in its charter)

             DELAWARE                                  04-3119555
      (State or other jurisdiction of             (I.R.S. Employer
      incorporation or organization)              Identification Number)

           CHARLESTOWN NAVY YARD
           BUILDING 75, THIRD AVENUE
           CHARLESTOWN, MASSACHUSETTS                02129
       (Address of Principal Executive Offices)    (Zip Code)

                         AMENDED 1991 STOCK OPTION PLAN
                            (Full title of the Plan)

                             ELLIOT LEBOWITZ, Ph.D.
                      PRESIDENT AND CHIEF EXECUTIVE OFFICER
                           BIOTRANSPLANT INCORPORATED
                              CHARLESTOWN NAVY YARD
                            BUILDING 75, THIRD AVENUE
                        CHARLESTOWN, MASSACHUSETTS 02129
                     (Name and address of agent for service)
                                 (617) 241-5200
          (Telephone number, including area code, of agent for service)

===============================================================================

                         CALCULATION OF REGISTRATION FEE

                                   Proposed      Proposed
      Title of                     maximum       maximum
      securities     Amount        offering      aggregate        Amount of
      to be          to be         price         offering         registration
      registered     registered    per share     price            fee
      ----------     ----------    ---------     ---------        ------------ 
      Common         727,226       $6.125 (1)  $4,454,259.25(1)   $1,349.78  
      Stock,         shares
      $0.01 par
      value per share
      --------------------------------------------------------------------------
      (1)  Estimated solely for the purpose of calculating the registration fee
           and based upon the average of the high and low trading prices of the
           Registrant's Common Stock, as reported on the Nasdaq National Market
           on October 29, 1996, in accordance with Rules 457(a) and 457(h) of
           the Securities Act of 1933.





<PAGE>   2


         PART I.  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

                   The information required by I of Form S-8 is included in
         documents sent or given to participants in the Amended 1991 Stock
         Option Plan of BioTransplant Incorporated, a Delaware corporation (the
         "Registrant"), pursuant to Rule 428(b)(1) of the Securities Act of
         1933, as amended (the "Securities Act").


         PART II.  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

              Item 3.  Incorporation of Certain Documents by Reference
                       -----------------------------------------------

                   The following documents, which are filed with the Securities
         and Exchange Commission (the "Commission"), are incorporated in this
         Registration Statement by reference:

                   (1) The Registrant's latest prospectus filed pursuant to Rule
              424(b) under the Securities Act that contains audited financial
              statements for the Registrant's latest fiscal year for which such
              statements have been filed.

                   (2) All other reports filed pursuant to Sections 13(a) or
              15(d) of the Exchange Act since the end of the fiscal year covered
              by the prospectus referred to in (1) above.

                   (3) The description of the Common Stock of the Registrant,
              $0.01 par value per share (the "Common Stock"), contained in the
              Registrant's Registration Statement on Form 8-A filed under the
              Exchange Act, including any amendment or report filed for the
              purpose of updating such information.

                   All documents subsequently filed by the Registrant pursuant
         to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act
         of 1934, as amended (the "Exchange Act"), prior to the filing of a
         post-effective amendment which indicates that all shares of Common
         Stock offered hereby have been sold or which deregisters all shares of
         Common Stock then remaining unsold, shall be deemed to be incorporated
         by reference herein and to be part hereof from the date of the filing
         of such documents.


              Item 4.  Description of Securities
                       -------------------------

                   Not applicable.


              Item 5.  Interests of Named Experts and Counsel
                       --------------------------------------

                   Not applicable.








                                      II-1

<PAGE>   3




              Item 6.  Indemnification of Directors and Officers
                       -----------------------------------------
  
                   Section 145 of the General Corporation Law of Delaware
         provides that a corporation has the power to indemnify a director,
         officer, employee or agent of the corporation and certain other persons
         serving at the request of the corporation in related capacities against
         amounts paid and expenses inccred in connection with an action or
         proceeding to which such person is or is threatened to be made a party
         by reason of such position, if such person shall have acted in good
         faith and in a manner reasonably believed to be in or not opposed to
         the best interests of the corporation, and, in any criminal proceeding,
         if such person had no reasonable cause to believe such conduct was
         unlawful; provided that, in the case of actions brought by or in the
         right of the corporation, no indemnification shall be made with respect
         to any matter as to which such person shall have been adjudged to be
         liable to the corporation unless and only to the extent that the
         adjudicating court determines that such indemnification is proper under
         the circumstances.

                   Article X of the Registrant's Certificate of Incorporation
         provides that a director or officer of the Registrant (a) shall be
         indemnified by the Registrant against all expenses (including
         attorney's fees), judgments, fines and amounts paid in settlement
         reasonably incurred in connectin with any litigation or other legal
         proceeding (other than an action by or in the right of the Registrant)
         brought against such director or officer by virtue of a position as a
         director or officer of the Registrant if such director or officer acted
         in good faith and in a manner reasonably believed by such director to
         be in or not opposed to the best interests of the Registrant, and, with
         respect to any criminal action or proceeding, such director had no
         reasonble cause to believe such conduct was unlawful and (b) shall be
         indemnified by the Registrant against expenses (including attorneys'
         fees) and amounts paid in settlement reasonably incurred in connection
         with any action by or in the right of the Registrant by virtue of a
         position as a director or officer of the Registratnt if such officer or
         director acted in good faith and in a manner reasonably believed to be
         in or not opposed to the best interests of the Registrant, except that
         no indemnification shall be made with respect to any such matter as to
         which such director or officer shall have been adjudged to be liable to
         the Registrant, unless and only to the extent that a court determines
         that, despite the adjudication of liability but in view of all the
         circumstances of the case, such person is fairly and reasonably
         entitled to indemnity for such expenses as the court deems proper.
         Nothwithstanding the foregoing, to the extent that a director or
         officer has been successful, on the merits or otherwise, such person
         shall be indemnified against all expenses (including attorney's fees)
         reasonably incurred in connection therewith.











                                      II-2
<PAGE>   4


         Expenses incurred in defending a civil or criminal action, suit or
         proceeding shall be advanced by the Registrant to a director or
         officer, at such person's request, upon receipt of an undertaking by
         the director or officer to repay such amount if it is ultimately
         determined that such pereson is not entitled to indemnification.

                   Indemnification is required to be made unless the Registrant
         determines that the applicable standard of conduct required for
         information has not been met. In the event of a determination by the
         Registrant that the director or officer did not meet applicable
         standard of conduct required for indemnification, or if the Registrant
         fails to make an indemnification payment within 60 days after such
         payment is claimed by such person, such person is permitted to petition
         a court to make an independent determination as to whether such person
         is entitled to indemnification. As a condition precedent to the right
         of indemnification, the director or officer must give the Registrant
         notice of the action for which indemnity is sought and the Registrant
         has the right to participate in such action or assume the defense
         thereof.

                   Article X of the Registrant's Certificate of Incorporation
         further provides that the indemnification provided therein is not
         exclusive, and provides that in the event that the Delaware General
         Corporation Law is amended to expand the indemnification permitted to
         directors or officers, the Registrant must indemnify those persons to
         the fullest extent permitted by such law as so amended.

                   Article IX of the Registrant's Certificate of Incorporation
         provides that, except to the extent that the General Corporation Law of
         Delaware prohibits the elimination or limitation of liability of
         directors for breaches of fiduciary duty, no director of the Registrant
         shall be personally liable to the Registrant or its stockholders for
         monetary damages for any breach of fiduciary duty as a director.

                   The Registrant has purchased a general liability insurance
         policy which covers certain liabilities of directors and officers of
         the Registrant arising out of claims based on acts or omissions in
         their capacity as directors or officers.

              Item 7.  Exemption from Registration Claimed
                       -----------------------------------
 
                   Not applicable.


              Item 8.  Exhibits
                       --------

                   The Exhibit Index immediately preceding the exhibits is
         incorporated herein by reference.






                                      II-3

<PAGE>   5




              Item 9.  Undertakings
                       ------------

              1.   The Registrant hereby undertakes:

                   (a) To file, during any period in which offers or sales are
              being made, a post-effective amendment to this Registration
              Statement:

                  (i)   To include any prospectus required by Section 10(a)(3) 
                        of the Securities Act;

                 (ii)   To reflect in the prospectus any facts or events arising
                        after the effective date of the Registration Statement
                        (or the most recent post-effective amendment thereof)
                        which, individually or in the aggregate, represent a
                        fundamental change in the information set forth in the 
                        Registration Statement; and

                (iii)   To include any material information with respect to the
                        plan of distribution not previously disclosed in the
                        Registration Statement or any material change to such
                        information in the Registration Statement;

              PROVIDED, HOWEVER, that paragraphs (i) and (ii) do not apply if
              the Registration Statement is on Form S-3 or Form S-8, and the
              information required to be included in a post-effective amendment
              by those paragraphs is contained in periodic reports filed by the
              Registrant pursuant to Section 13 or Section 15(d) of the Exchange
              Act that are incorporated by reference in the Registration
              Statement.

                   (b) That, for the purpose of determining any liability under
              the Securities Act, each such post-effective amendment shall be
              deemed to be a new Registration Statement relating to the
              securities offered therein, and the offering of such securities at
              that time shall be deemed to be the initial bona fide offering
              thereof.

                   (c) To remove from registration by means of a post-effective
              amendment any of the securities being registered which remain
              unsold at the termination of the offering.

              2. The Registrant hereby undertakes that, for purposes of
         determining any liability under the Securities Act, each filing of the
         Registrant's annual report pursuant to Section 13(a) or Section 15(d)
         of the Exchange Act (and, where applicable, each filing of an employee
         benefit plan's annual report pursuant to Section 15(d) of the Exchange
         Act) that is incorporated by



















                                      II-4

<PAGE>   6









         reference in the Registration Statement shall be deemed to be a new
         Registration Statement relating to the securities offered therein, and
         the offering of such securities at that time shall be deemed to be the
         initial bona fide offering thereof.

              3. Insofar as indemnification for liabilities arising under the
         Securities Act may be permitted to directors, officers and controlling
         persons of the Registrant pursuant to the foregoing provisions, or
         otherwise, the Registrant has been advised that in the opinion of the
         Securities and Exchange Commission such indemnification is against
         public policy as expressed in the Securities Act and is, therefore,
         unenforceable. In the event that a claim for indemnification against
         such liabilities (other than the payment by the Registrant of expenses
         incurred or paid by a director, officer or controlling person of the
         Registrant in the successful defense of any action, suit or proceeding)
         is asserted by such director, officer or controlling person in
         connection with the securities being registered, the Registrant will,
         unless in the opinion of its counsel the matter has been settled by
         controlling precedent, submit to a court of appropriate jurisdiction
         the question whether such indemnification by it is against public
         policy as expressed in the Securities Act and will be governed by the
         final adjudication of such issue.

































                                      II-5

<PAGE>   7



                                   SIGNATURES

              Pursuant to the requirements of the Securities Act, the Registrant
         certifies that it has reasonable grounds to believe that it meets all
         of the requirements for filing on Form S-8 and has duly caused this
         Registration Statement to be signed on its behalf by the undersigned,
         thereunto duly authorized, in the Town of Charlestown, Commonwealth of
         Massachusetts, this 30th day of October, 1996.


                                            BioTransplant Incorporated




                                            By: /s/ Elliot Lebowitz
                                                ----------------------------
                                                Elliot Lebowitz
                                                President and
                                                Chief Executive Officer




                                 POWER OF ATTORNEY

              We, the undersigned officers and directors of BioTransplant
         Incorporated, hereby severally constitute and appoint Elliot Lebowitz,
         Richard V. Capasso and Steven D. Singer, and each of them singly, our
         true and lawful attorneys with full power to them, and each of them
         singly, to sign for us and in our names, in the capacities indicated
         below, the Registration Statement on Form S-8 filed herewith, and any
         and all subsequent amendments to said Registration Statement, and
         generally to do all such things in our names and on our behalf and in
         our capacities as officers and directors to enable BioTransplant
         Incorporated to comply with the provisions of the Securities Act of
         1933, as amended, and all requirements of the Securities and Exchange
         Commission, hereby ratifying and confirming our signatures as they may
         be signed by our said attorneys, or any of them, to said Registration
         Statement and any and all amendments thereto.















                                      II-6

<PAGE>   8




              Pursuant to the requirements of the Securities Act, this
         Registration Statement has been signed below by the following persons
         in the capacities and on the dates indicated.


               Signature                    Title               Date
               ---------                    -----               ----
   
         /s/ Elliot Lebowitz           President, Chief      October 30, 1996
         ---------------------------    Executive Officer
         Elliot Lebowitz                and Director
                                        (Principal Executive
                                        Officer)

         /s/ Richard V. Capasso        Director of           October 30, 1996
         ---------------------------    Finance (Principal
         Richard V. Capasso             Financial and
                                        Accounting Officer)


         /s/ William W. Crouse         Director              October 30, 1996
         ---------------------------
         William W. Crouse

         /s/ James C. Foster           Director              October 30, 1996
         ---------------------------
         James C. Foster

         /s/ Daniel O. Hauser          Director              October 30, 1996
         ---------------------------
         Daniel O. Hauser

                                       Director              October   , 1996
         ---------------------------
         Robert A. Vukovich

         /s/ Daniel P. Kearney         Director              October 30, 1996
         ---------------------------
         Daniel P. Kearney




















                                      II-7

<PAGE>   9


                                  Exhibit Index


    Exhibit
    Number       Description                                         Page
    ------       -----------                                         ----

       4.1 (1)   Restated Certificate of Incorporation,
                 as amended to date.                                 --

       4.2 (1)   By-laws, as amended to date                         --

       4.3 (1)   Specimen Certificate of Common Stock,               --
                 $0.01 par value, of the Registrant

       5         Opinion of Hale and Dorr

      23.1       Consent of Hale and Dorr                            --
                 (included in Exhibit 5)

      23.2       Consent of Arthur Andersen LLP

      24         Power of Attorney (included on the signature        --
                 page of this Registration Statement)























- ------------------    
(1)  Incorporated herein by reference to the Registrant's Registration Statement
     on Form S-1 (File No. 333-2144).






                                    

<PAGE>   1





                                October 31, 1996




         BioTransplant Incorporated
         Charlestown Navy Yard
         Building 75, Third Avenue
         Charlestown, MA  02129

         Ladies and Gentlemen:

              We have assisted in the preparation of a Registration Statement on
         Form S-8 (the "Registration Statement") to be filed with the Securities
         and Exchange Commission relating to shares of Common Stock, $.01 par
         value per share (the "Shares"), of BioTransplant Incorporated, a
         Delaware corporation (the "Company"), issuable under the Company's
         Amended 1991 Stock Option Plan (the "Plan").

              We have examined the Restated Certificate of Incorporation and
         Amended and Restated By-Laws of the Company, each as amended to date,
         the Registration Statement and originals, or copies certified to our
         satisfaction, of all pertinent records of the meetings of the directors
         and stockholders of the Company and such other documents relating to
         the Company as we have deemed material for the purposes of this
         opinion.

              In examination of the foregoing documents, we have assumed the
         genuineness of all signatures and the authenticity of all documents
         submitted to us as originals, the conformity to original documents of
         all documents submitted to us as certified or photostatic copies, and
         the authenticity of the originals of such latter documents.

              Based on the foregoing, we are of the opinion that the Shares
         covered by the Registration Statement have been duly authorized for
         issuance under the plan and the Shares, when issued against payment
         therefor in accordance with the terms of the Plan, will be legally
         issued, fully paid and non-assessable.


















<PAGE>   2










              We hereby consent to the filing of this opinion with the
         Securities and Exchange Commission as an Exhibit to the Registration
         Statement.

                                            Very truly yours,

                                            /s/ Hale and Dorr

                                            HALE AND DORR


















































<PAGE>   1

                                                                   Exhibit 23.2
          

                   CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS
                   -----------------------------------------


     As independent public accountants, we hereby consent to the incorporation
by reference in this Registration Statement of BioTransplant Incorporated on
Form S-8 of our report dated February 5, 1996 (except with respect to the
matters discussed in Notes 6(a) and 14, as to which the dates are May 6, 1996
and February 13, 1996, respectively) included in the Registration Statement on
Form S-1 (File No. 333-2144) of BioTransplant Incorporated and to all references
to our Firm included in this Registration Statement.


                                            /s/ Arthur Andersen LLP

                                            Arthur Andersen LLP



Boston Massachusetts
October 30, 1996


































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