BIOTRANSPLANT INC
10-Q, 1996-06-20
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1

================================================================================

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   -----------
                                    FORM 10-Q
                                   -----------

(Mark One)


X   Quarterly report pursuant to Section 13 or 15(d) of the Securities Exchange
- -   Act of 1934

FOR THE PERIOD ENDED MARCH 31, 1996

                                       OR

__  Transition report pursuant to Section 13 or 15(d) of the Securities Exchange
    Act of 1934


COMMISSION FILE NUMBER: 0-28324


                           BIOTRANSPLANT INCORPORATED
             (Exact name of registrant as specified in its charter)


               DELAWARE                                   04-3119555
     (State or other jurisdiction of                  (I.R.S. Employer
      incorporation or organization)                  Identification No.)


                 CHARLESTOWN NAVY YARD, BUILDING 75 THIRD AVENUE
                        CHARLESTOWN, MASSACHUSETTS 02129
                    (Address of principal executive offices)


                                 (617) 241-5200
              (Registrant's telephone number, including area code)


     Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days:

                    Yes            No  X *
                        ---           ---

* All forms have been filed as required; the registrant has not been subject to 
                 such filing requirements for the past 90 days.


     As of June 12, 1996, there were 8,548,748 shares of the Registrant's Common
Stock outstanding.

================================================================================

<PAGE>   2
                           BIOTRANSPLANT INCORPORATED
                                    FORM 10-Q
                                      INDEX



<TABLE>
                          PART I. FINANCIAL INFORMATION
<CAPTION>

                                                                            Page No.
                                                                            --------

<S>      <C>                                                                    <C>
ITEM 1.  CONDENSED CONSOLIDATED FINANCIAL STATEMENTS:

         Condensed Consolidated Balance Sheets as of December 31, 1995,
         March 31, 1996 and Pro Forma as of March 31, 1996...................... 3

         Condensed Consolidated Statement of Operations for three months
         ended March 31, 1995 and 1996, and for the period from
         inception (March 20, 1990) to March 31, 1996 .......................... 4
                                                                                 
         Condensed Consolidated Statement of Cash Flows for three months
         ended March 31, 1995 and 1996, and for the period from
         inception (March 20, 1990) to March 31, 1996 .......................... 5

         Notes to Condensed Consolidated Financial Statements................... 6

ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
          AND RESULTS OF OPERATIONS............................................. 8

                           PART II. OTHER INFORMATION

ITEM 6.  EXHIBITS AND REPORTS ON FORM 8-K...................................... 12

         SIGNATURES............................................................ 12
</TABLE>


                                       2

<PAGE>   3


PART I. FINANCIAL INFORMATION
ITEM 1. CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
                    BIOTRANSPLANT INCORPORATED AND SUBSIDIARY
                          (A DEVELOPMENT STAGE COMPANY)
<TABLE>
                                     CONDENSED CONSOLIDATED BALANCE SHEETS
                                                  (UNAUDITED)
<CAPTION>

                                                                                                    Pro Forma
                                                                   December 31,     March 31,       March 31,
                                                                       1995            1996            1996
                                                                   ------------    ------------    ------------

<S>                                                                <C>             <C>             <C>         
ASSETS
Current assets:
         Cash and cash equivalents                                 $  2,848,549    $  6,167,920    $ 34,166,620
         Accounts receivable                                            250,000          24,168          24,168
         Deposits and other prepaid expenses                            343,303         373,521         373,521
                                                                   ------------    ------------    ------------
                  Total current assets                                3,441,852       6,565,609      34,564,309

Property and equipment - net                                          1,830,219       1,684,299       1,684,299
Other assets                                                             99,563         157,476         157,476
                                                                   ------------    ------------    ------------
TOTAL ASSETS                                                       $  5,371,634    $  8,407,384    $ 36,406,084
                                                                   ============    ============    ============

LIABILITIES AND STOCKHOLDERS' EQUITY 
Current liabilities:
         Current obligation under capital leases                   $    450,768    $    435,109    $    435,109
         Accounts payable                                               187,225         189,410         189,410
         Accrued expenses                                               967,430         917,745         917,745
         Deferred revenue                                             1,750,000              --              --
                                                                   ------------    ------------    ------------
                  Total current liabilities                           3,355,423       1,542,264       1,542,264
                                                                   ------------    ------------    ------------
Long-term obligation under capital lease                                614,939         506,449         506,449
                                                                   ------------    ------------    ------------
Convertible notes payable to stockholders                             1,000,000              --              --
                                                                   ------------    ------------    ------------
Redeemable convertible preferred stock, $.01 par value, 
         authorized 19,110,521 shares, issued and 
         outstanding 15,586,345 and 19,081,754 shares 
         at December 31, 1995 and March 31, 1996,
         respectively, and no shares pro forma                       29,241,474      36,186,820              --   
                                                                   ------------    ------------    ------------
Stockholders' equity (deficit):
Preferred stock, $.01 par value, authorized 2,000,000
         shares, issued and outstanding - no shares                          --              --              --   
Common stock, $.01 par value, authorized 25,000,000
         shares, issued and outstanding 126,594 shares
         at December 31, 1995 and March 31, 1996, and
         8,548,748 shares pro forma                                       1,266           1,266          85,487
Additional paid-in capital                                            1,230,343       1,230,343      65,331,642
Accumulated deficit                                                 (30,071,811)    (31,059,758)    (31,059,758)
                                                                   ------------    ------------    ------------
                  Total stockholders equity (deficit)               (28,840,202)    (29,828,149)     34,357,371
                                                                   ------------    ------------    ------------
TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY                         $  5,371,634    $  8,407,384    $ 36,406,084
                                                                   ============    ============    ============
</TABLE>


   The accompanying notes are an integral part of these consolidated financial
                                   statements.


                                       3
<PAGE>   4


                  BIOTRANSPLANT INCORPORATED AND SUBSIDIARY
                        (A DEVELOPMENT STAGE COMPANY)
<TABLE>
                     CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                                       (UNAUDITED)
<CAPTION>

                                           Three Months Ended March 31,
                                           ----------------------------   Cumulative Since
                                                 1995          1996          Inception
                                             -----------    ----------      ------------
<S>                                          <C>            <C>             <C>         
Revenues:                                                                               
        License fees                         $        --    $       --      $  7,000,000
        Research and development                 375,000     2,000,000        10,500,000
        Interest income                           59,309        75,697           601,174
                                             -----------    ----------      ------------
               Total revenues                    434,309     2,075,697        18,101,174
                                             -----------    ----------      ------------
                                                                         
Expenses:                                                                
        Research and development               2,530,036     2,555,630        38,830,837
        General and administrative               430,616       456,806         8,722,405
        Interest                                 193,091        51,208         1,607,690
                                             -----------    ----------      ------------
               Total expenses                  3,153,743     3,063,644        49,160,932
                                             -----------    ----------      ------------
Net loss                                     $(2,719,434)   $ (987,947)     $(31,059,758)
                                             ===========    ==========      ============
Pro forma net loss per common share          $     (0.68)   $    (0.19)
                                             ===========    ==========
Shares used in computing pro forma net     
        loss per common share                  4,008,979     5,131,246
                                             ===========    ==========
</TABLE>


  The accompanying notes are an integral part of these consolidated financial
                                  statements.


                                       4
<PAGE>   5


                    BIOTRANSPLANT INCORPORATED AND SUBSIDIARY
                          (A DEVELOPMENT STAGE COMPANY)
<TABLE>
                                     CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                                                       (UNAUDITED)
<CAPTION>

                                                                          Three Months Ended March 31,
                                                                          ----------------------------  Cumulative Since
                                                                               1995           1996         Inception
                                                                           -----------    -----------     -------------
<S>                                                                        <C>            <C>             <C>          
Cash flows from operating activities:
        Net loss                                                           $(2,719,434)   $  (987,947)    $(31,059,758)
        Adjustments to reconcile net loss to net cash                                                    
             provided by (used) in operating activities:                                                 
             Depreciation and amortization                                     204,162        175,050        2,051,817
             Noncash interest expense                                               --         15,583          505,710
             Noncash expenses related to options                                                         
                 and warrants                                                   42,556             --        1,085,683
             Changes in current assets and liabilities:                                                  
                 Accounts receivable                                            (8,339)       225,832          (24,168)
                 Deposits and prepaid expenses                                  61,061        (30,218)        (373,521)
                 Accounts payable                                             (273,308)         2,185          189,410
                 Accrued expenses                                              431,370         (9,452)         917,745
                 Deferred revenue                                            3,625,000     (1,750,000)              --
                                                                           -----------    -----------     ------------
             Net cash provided by (used in) operating activities             1,363,068     (2,358,967)     (26,707,082)
                                                                           -----------    -----------     ------------
Cash flows from investing activities:                                                                    
        Purchases of property and equipment                                    (58,826)       (29,130)      (3,111,383)
        Disposal of property and equipment, net                                     --             --           28,040
        Increase in other assets                                                    --        (57,913)         (57,913)
                                                                           -----------    -----------     ------------
             Net cash used in investing activities                             (58,826)       (87,043)      (3,141,256)
                                                                           -----------    -----------     ------------
Cash flows from financing activities:                                                                    
        Proceeds from convertible notes payable to stockholders                     --             --        9,400,000
        Payments of obligations under capital leases                          (138,128)      (124,149)      (1,252,651)
        Proceeds from sale/leaseback of equipment                                   --             --          771,968
        Net proceeds from equipment leases                                          --             --        1,422,240
        Net proceeds from sale of redeemable convertible preferred stock            --      5,889,530       25,661,526
        Proceeds from sale of common stock                                         183             --           13,175
                                                                           -----------    -----------     ------------
             Net cash provided by (used for) financing activities             (137,945)     5,765,381       36,016,258
                                                                           -----------    -----------     ------------
Net increase in cash and cash equivalents                                    1,166,297      3,319,371        6,167,920

Cash and cash equivalents, beginning of period                               2,343,126      2,848,549               --
                                                                           -----------    -----------     ------------
Cash and cash equivalents, end of period                                   $ 3,509,423    $ 6,167,920     $  6,167,920
                                                                           ===========    ===========     ============
Supplemental disclosures and noncash transactions:                                                       
        Increase in equipment under capital leases                         $        --    $        --     $ (2,210,270)
                                                                           ===========    ===========     ============
        Conversion of convertible notes payable to stockholders and                                      
         accrued interest into redeemable convertible preferred stock      $        --    $ 1,055,816     $  9,905,710
                                                                           ===========    ===========     ============
        Issuance of warrants                                               $        --    $        --     $    741,737
                                                                           ===========    ===========     ============
        Interest paid during the period                                    $    84,598    $    35,611     $  1,250,540
                                                                           ===========    ===========     ============
</TABLE>


   The accompanying notes are an integral part of these consolidated financial
                                  statements.


                                       5
<PAGE>   6

                    BIOTRANSPLANT INCORPORATED AND SUBSIDIARY
                          (A DEVELOPMENT STAGE COMPANY)
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                   (UNAUDITED)


1.    OPERATIONS AND BASIS OF PRESENTATION

BioTransplant Incorporated (the "Company") was incorporated on March 20, 1990.
The Company is developing proprietary anti-rejection pharmaceuticals and organ
transplantation systems which represent a comprehensive approach to inducing
long-term specific transplantation tolerance in humans.

The Company is in the development stage and is devoting substantially all of
its efforts toward product research and development and raising capital. The
Company is subject to a number of risks similar to those of other development
stage companies, including dependence on key individuals, competition from
substitute products and larger companies, the development of commercially usable
products, obtaining regulatory approval for products under development, the
development and marketing of commercial products, and the need to obtain
adequate additional financing necessary to fund the development of its products.

During May 1996, the Company completed an initial public offering of 3,220,000
of common stock resulting in net proceeds of approximately $28.0 million (see
Note 6).

The financial statements herein have been prepared by the Company, without
audit, pursuant to the rules and regulations of the Securities and Exchange
Commission ("SEC") and include, in the opinion of management, all adjustments,
consisting of normal, recurring adjustments, necessary for a fair representation
of interim period results. Certain information and footnote disclosures normally
included in financial statements prepared in accordance with generally accepted
accounting principles have been condensed or omitted pursuant to such rules and
regulations. The results for the interim periods presented are not necessarily
indicative of results to be expected for the fiscal year or any future period.
It is suggested that these condensed consolidated financial statements be read
in conjunction with the audited consolidated financial statements and the notes
thereto included in the Company's initial public offering Prospectus dated May
8, 1996, which is part of the Company's Registration Statement on Form S-1, as
amended and filed with the SEC (Reg. No. 333-2144).

2.    CASH AND CASH EQUIVALENTS

Cash and cash equivalents are stated at cost, which approximates market value,
and include short-term, highly liquid investments with original maturities of
less than three months from the date of purchase.



 

                                      6
<PAGE>   7


3.    PRO FORMA NET LOSS PER COMMON SHARE

Pro forma net loss per common share is based on the pro forma weighted average
number of common shares outstanding during the periods presented, assuming the
automatic conversion of all shares of Series A, B, D and E redeemable
convertible preferred stock then outstanding into 3,212,896 and 3,896,580 shares
of common stock at March 31, 1995 and 1996, respectively. Pursuant to the
requirements of the SEC , common stock and preferred stock issued during the 12
months immediately preceding the initial public offering, plus shares of common
stock that became issuable during the same period pursuant to the grant of
common stock options and warrants, have been included in the calculation of pro
forma weighted average number of common shares outstanding for the entire period
using the treasury stock method. Historical net loss per share has not been
presented as such information is not considered to be relevant or meaningful.

4.    CONVERSION OF NOTES PAYABLE TO STOCKHOLDERS

During February 1996, the Company converted the $1,000,000 note payable to
stockholders and $55,816 of accrued interest into 527,909 shares of Series D
redeemable convertible preferred stock, which automatically converted into
131,975 shares of common stock upon the closing of the initial public offering
discussed in Note 6.

5.    SALE OF SERIES D PREFERRED STOCK

During January and February 1996, the Company sold an aggregate of 2,967,500
shares of Series D redeemable convertible preferred stock for net proceeds of
approximately $5,890,000. These preferred shares automatically converted
into 741,875 shares of common stock upon the closing of the initial public
offering discussed in Note 6.

6.    INITIAL PUBLIC OFFERING

In May 1996, the Company completed an initial public offering of 3,220,000
shares of common stock for $9.50 per share, resulting in net proceeds of
approximately $28.0 million. In addition, all outstanding shares of Series A, B,
D and E redeemable convertible preferred stock were automatically converted into
5,202,154 shares of common stock upon the closing of the initial public
offering.

The pro forma balance sheet as of March 31, 1996 reflects the effect of the
initial public offering, including the automatic conversion of all outstanding
redeemable convertible preferred stock into common stock and the receipt of the
net proceeds therefrom, as if it had occurred on March 31, 1996.




                                       7
<PAGE>   8


                           BIOTRANSPLANT INCORPORATED

ITEM 2.     MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND 
            RESULTS OF OPERATIONS

The following discussion of the financial condition and results of operations of
the Company for the three months ended March 31, 1995 and 1996 should be read in
conjunction with the accompanying unaudited condensed consolidated financial
statements and the related notes thereto.

This report may contain certain forward looking statements which involve risks
and uncertainties. Such statements are subject to certain factors which may
cause the Company's plans and results to differ significantly from the plans and
results discussed in forward looking statements. Factors that may cause such
differences include, but are not limited to, the progress of the Company's
research and development programs, the Company's ability to compete
successfully, the Company's ability to attract and retain qualified personnel,
the Company's ability to enter into and maintain collaborations with third
parties, the Company's ability to enter into and progress in clinical trials,
the time and costs involved in obtaining regulatory approvals, the costs
involved in obtaining and enforcing patents, proprietary rights and any
necessary licenses, the ability of the Company to establish development and
commercialization capacities or relationships, the costs of manufacturing, the
Company's ability to obtain additional funds, and those other risks discussed
under the heading "Risk Factors" in the Prospectus dated May 8, 1996 included in
the Company's Registration Statement on Form S-1, as amended (Reg. No.
333-2144).

OVERVIEW

Since commencement of operations in 1990, the Company has been a development
stage company engaged primarily in the research and development of proprietary
anti-rejection pharmaceuticals and organ transplantation systems which
represent a comprehensive approach to inducing long-term specific
transplantation tolerance in humans. The major sources of the Company's working
capital have been the proceeds of equity placements, sponsored research funding
and license fees and capital lease financings. The Company has not generated
any revenues from the sales of products to date, and does not expect to receive
any product revenues for several years. The Company will be required to conduct
significant research, development, testing and regulatory compliance activities
that, together with general and administrative expenses, are expected to result
in significant and increasing operating losses for at least the next several
years.

In 1993, and as amended and restated in September 1995, the Company and Sandoz
entered into a collaboration agreement for the development and
commercialization of xenotransplantation products utilizing gene transduction.
Under the agreement, Sandoz has committed research funding through March 1998
of $20.0 million, of which $10.0 million had been received as of March 31,
1996, and agreed to pay license fees of $10.0 million, of which $5.0 million
had been received as of March 31, 1996. Sandoz has also agreed to fund certain
development and premarketing costs of such products, portions of which, 





                                       8
<PAGE>   9


under certain circumstances, may be repayable from the Company's operating
profits from sales of such products.

In October 1995, the Company and MedImmune formed a collaborative research
agreement for the development of products to treat and prevent organ rejection.
MedImmune paid the Company a $2.0 million license fee at the time of execution
of the agreement, and agreed to fund and assume responsibility for clinical
testing and commercialization of BTI-322 and other related products. MedImmune
has agreed to provide research support and make milestone payments which could
total up to an additional $14.0 million, of which $500,000 had been received as
of March 31, 1996.


RESULTS OF OPERATIONS
THREE MONTHS ENDED MARCH 31, 1996 AND 1995

Revenues increased to $2.1 million for the three months ended March 31, 1996
from $434,000 for the three months ended March 31, 1995. The increase in
revenues was due to increased research and development revenues which consisted
of increased funding from Sandoz of $1.4 million for the three months ended
March 31, 1996 as a result of the amendment and restatement of the collaboration
agreement and $250,000 in research support revenue recognized in connection with
the collaboration formed with MedImmune.

Research and development expenses increased to $2.6 million for the three months
ended March 31, 1996 from $2.5 million for the three months ended March 31,
1995. This increase was primarily due to increases in research and development
staff together with the associated increases in supplies and support services,
partially offset by decreased expenditures related to the human clinical safety
trials for BTI-322.

General and administrative expenses increased to $457,000 for the three months
ended March 31, 1996 from $431,000 for the three months ended March 31, 1995.
This increase was primarily due to increases in outside professional services in
connection with market research and business development in part offset by
decreased salary and related expenses for general and administrative personnel.

Interest income increased to $76,000 for the three months ended March 31, 1996
from $59,000 for the three months ended March 31, 1995. The increase was due
primarily to higher cash balances available for investment.

Interest expense decreased to $51,000 for the three months ended March 31, 1996
from $193,000 for the three months ended March 31, 1995. The decrease was
primarily due to the conversion of $4.4 million and $1.0 million of convertible
notes payable, and the accrued interest thereon, to stockholders into redeemable
convertible preferred stock in October 1995 and February 1996, respectively. The
redeemable convertible preferred stock was then automatically converted into
738,208 shares of common stock upon the closing of the Company's initial public









 
                                      9
<PAGE>   10


offering. In addition, the decrease was in part attributable to decreasing
balances on existing obligations under capital leases

Net loss for the three months ended March 31, 1996 was $988,000, or $0.19 per
share, compared to a net loss of $2.7 million, or $0.68 per share for the three
months ended March 31, 1995.

LIQUIDITY AND CAPITAL RESOURCES

On May 8, 1996, the Company completed an initial public offering of 2,800,000
shares of common stock at a price of $9.50 per share, and received net proceeds
of approximately $24.3 million. In addition, all outstanding shares of Series A,
B, D and E redeemable convertible preferred stock were automatically converted
into 5,202,154 shares of common stock upon the closing of the initial public
offering. On May 18, 1996, the underwriters of the offering exercised their
over-allotment option to purchase an additional 420,000 shares of common stock
resulting in additional net proceeds of approximately $3.7 million to the
Company.

Since its inception and prior to the completion of the Company's initial public
offering, the Company's operations have been funded principally through the net
proceeds of an aggregate of $36.2 million from private placements of equity
securities. The Company has also received $15.0 million from a research and
development and collaboration agreement with Sandoz, $2.5 million from an
alliance agreement with MedImmune and $2.2 million in equipment lease
financing. The proceeds of the private placements, notes payable and capital
leases and cash generated from the corporate collaborations with Sandoz and
MedImmune have been used to fund operating losses of approximately $31.1
million and the investment of approximately $3.7 million in equipment and
leasehold improvements through March 31, 1996. The Company had no significant
commitments as of March 31, 1996 for capital expenditures.

During the three months ended March 31, 1996, the Company paid Stem Cell
Sciences $250,000 of a $500,000 commitment for research support and to maintain
its pro rata equity interest in Stem Cell Sciences. In addition, the Company has
an option to purchase additional shares of Stem Cell Sciences prior to July
1996, to maintain its pro rata equity interest and provide research support. If
the Company does not make such further investment, its rights to certain
technologies become nonexclusive.

The Company had cash and cash equivalents and working capital of $34.2 and $33.0
million, respectively, on a pro forma basis as of March 31, 1996, reflecting the
net proceeds of $28.0 million from the initial public offering as described
above.

The Company has entered into sponsored research and consulting agreements with
certain hospitals, academic institutions and consultants, requiring periodic
payments by the Company. Aggregate minimum funding obligations under these
agreements, which include certain cancellation provisions, total approximately
$5.0 million, which includes approximately $2.4 million and $776,000 in 1996 and
1997, respectively.





                                       10

<PAGE>   11


The Company anticipates that its existing funds, together with the proceeds from
its initial public offering and the exercise of the over-allotment option, and
interest earned thereon should be sufficient to fund its operating and capital
requirements as currently planned through the end of 1997. However, the
Company's cash requirements may vary materially from those now planned, due to
many factors, including, but not limited to, the progress of the Company's
research and development programs, the scope and results of preclinical and
clinical testing, changes in existing and potential relationships with corporate
collaborators, the time and cost in obtaining regulatory approvals, the costs
involved in obtaining and enforcing patents, proprietary rights and any
necessary licenses, the ability of the Company to establish development and
commercialization capacities or relationships, the costs of manufacturing and
other factors. 

The Company expects to incur substantial additional costs, including costs
related to research and development activities, preclinical studies, clinical
trials, obtaining regulatory approvals, manufacturing and the expansion of its
facilities. The Company will need to raise substantial additional funds, through
additional financings including public or private equity offerings and
collaborative arrangements with corporate partners. There can be no assurance
that funds will be available on terms acceptable to the Company, if at all. If
adequate funds are not available, the Company may be required to delay, scale
back or eliminate certain of its product development programs or to license to
others the right to commercialize products or technologies that the Company
would otherwise seek to develop and commercialize itself, any of which would
have a material and adverse effect on the Company.





                                       11


<PAGE>   12


                           BIOTRANSPLANT INCORPORATED

PART II. OTHER INFORMATION

ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K

a)    Exhibits
      4.1   Restated Certificate of Incorporation, as amended to date. 
      4.2   By-laws, as amended to date.
      11.1  Statement: Computation of Pro Forma Net Loss Per Common Share
      27    Financial Data Schedule.

b)    Reports on Form 8-K
      None.


                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.



                                    BioTransplant Incorporated
                                   (Registrant)

Date: June 20, 1996                 /s/ Elliot Lebowitz
                                    ---------------------------
                                    Elliot Lebowitz
                                    President and Chief
                                    Executive Officer


                                    /s/ Richard V. Capasso
                                    ---------------------------
                                    Richard V. Capasso
                                    Director of Finance




<PAGE>   1


                                                                   EXHIBIT 4.1

                        RESTATED CERTIFICATE OF INCORPORATION
                                       OF
                           BIOTRANSPLANT INCORPORATED

              (originally Bio-Transplant, Inc. and BioTransplant, Inc.)
                          (Incorporated March 20, 1990)

                         Pursuant to Section 242 and 245
                         of the General Corporation Law
                            of the State of Delaware


              BIOTRANSPLANT INCORPORATED (the "Corporation"), a corporation
         organized and existing under and by virtue of the General Corporation
         Law of the State of Delaware (the "General Corporation Law"), hereby
         certifies as follows:

              FIRST: The name of the Corporation is BioTransplant Incorporated.
         A Certificate of Incorporation of the Corporation originally was filed
         by the Corporation with the Secretary of State of Delaware on March 20,
         1990. A Restated Certificate of Incorporation was filed on October 4,
         1991 and was amended on December 12, 1991 and December 20, 1991. A
         Second Amended and Restated Certificate of Incorporation was filed on
         May 15, 1992. A Third Amended and Restated Certificate of Incorporation
         was filed on October 29, 1993. A Fourth Amended and Restated
         Certificate of Incorporation was filed on March 3, 1994. A Fifth
         Amended and Restated Certificate of Incorporation was filed on August
         24, 1994 and was amended on August 18, 1995. A Sixth Amended and
         Restated Certificate of Incorporation was filed on October 31, 1995 and
         was amended on January 23 and May 6, 1996.

              SECOND: This Restated Certificate of Incorporation which restates
         and integrates and further amends the Certificate of Incorporation of
         the Corporation, as amended, was duly adopted in accordance with the
         provisions of Section 242 and 245 of the General Corporation Law, and
         was approved by written consent of the stockholders of the Corporation
         given in accordance with the provisions of Section 228 of the General
         Corporation Law (prompt notice of such action having been given to
         those stockholders who did not consent in writing).

              THIRD:    The text of the Certificate of Incorporation, as
         amended, is hereby restated and amended to read in its entirety as
         follows:

                                    ARTICLE I
                                      Name

              The name of the corporation is BioTransplant Incorporated.




<PAGE>   2




                                   ARTICLE II
                                     Purpose

              The Corporation is organized to engage in any lawful act or
         activity for which a corporation may be organized under the General
         Corporation Law of the State of Delaware.

                                   ARTICLE III
                                  Capital Stock

              (a) Authorization. The total number of shares of all classes of
         stock which the Corporation shall have authority to issue is 27,000,000
         shares, consisting of 25,000,000 shares of Common Stock, $.01 par value
         per share ("Common Stock"), and 2,000,000 shares of Preferred Stock,
         $.01 par value per share ("Preferred Stock").

                              PART A. Common Stock

              A.1 General. The voting, dividend and liquidation rights of the
         holders of the Common Stock are subject to and qualified by the rights
         of the holders of Preferred Stock of any Series as may be designated by
         the Board of Directors upon any issuance of the Preferred Stock of any
         Series.

              A.2 Voting. The holders of the Common Stock are entitled to one
         vote for each share held at all meetings of stockholders (and written
         actions in lieu of meetings). There shall be no cumulative voting.

              The number of authorized shares of Common Stock may be increased
         or decreased (but not below the number of shares thereof then
         outstanding) by the affirmative vote of the holders of a majority of
         the stock of the Corporation entitled to vote, irrespective of the
         provisions of Section 242(b)(2) of the General Corporation Law of
         Delaware.

              A.3 Dividends. Dividends may be declared and paid on the Common
         Stock from funds lawfully available therefor as and when determined by
         the Board of Directors and subject to any preferential dividend rights
         of any then outstanding Preferred Stock.

              A.4 Liquidation. Upon the dissolution or liquidation of the
         Corporation, whether voluntary or involuntary, holders of Common Stock
         will be entitled to receive all assets of the Corporation available for
         distribution to its stockholders, subject to any preferential rights of
         any then outstanding Preferred Stock.




                                       -2-


<PAGE>   3





                             PART B. PREFERRED STOCK

              Preferred Stock may be issued from time to time in one or more
         series, each of such series to have such terms as stated or expressed
         herein and in the resolution or resolutions providing for the issue of
         such series adopted by the Board of Directors of the Corporation as
         hereinafter provided. Any shares of Preferred Stock which may be
         redeemed, purchased or acquired by the Corporation may be reissued
         except as otherwise provided by law. Different series of Preferred
         Stock shall not be construed to constitute different classes of shares
         for the purposes of voting by classes unless expressly provided.

              Authority is hereby expressly granted to the Board of Directors
         from time to time to issue the Preferred Stock in one or more series,
         and in connection with the creation of any such series, by resolution
         or resolutions providing for the issue of the shares thereof, to
         determine and fix such voting powers, full or limited, or no voting
         powers, and such designations, preferences and relative participating,
         optional or other special rights, and qualifications, limitations or
         restrictions thereof, including without limitation thereof, dividend
         rights, conversion rights, redemption privileges and liquidation
         preferences, as shall be stated and expressed in such resolutions, all
         to the full extent now or hereafter permitted by the General
         Corporation Law of Delaware. Without limiting the generality of the
         foregoing, the resolutions providing for issuance of any series of
         Preferred Stock may provide that such series shall be superior or rank
         equally or be junior to the Preferred Stock of any other series to the
         extent permitted by law. Except as otherwise provided in this
         Certificate of Incorporation, no vote of the holders of the Preferred
         Stock or Common Stock shall be a prerequisite to the designation or
         issuance of any shares of any series of the Preferred Stock authorized
         by and complying with the conditions of this Certificate of
         Incorporation, the right to have such vote being expressly waived by
         all present and future holders of the capital stock of the Corporation.

                                   ARTICLE IV
                                Registered Agent

              The address of the registered office of the Corporation in the
         State of Delaware is Corporation Trust Center, 1209 Orange Street,
         Wilmington, Delaware 19801. The name of the registered agent of the
         Corporation at such address is The Corporation Trust
         Company.






                                       -3-


<PAGE>   4







                                    ARTICLE V
                                     By-laws

              In furtherance and not in limitation of the powers conferred by
         the laws of the State of Delaware, the Board of Directors is expressly
         authorized to adopt, amend or repeal the By-laws of the Corporation.

                                   ARTICLE VI
                               Perpetual Existence

              The Corporation is to have perpetual existence.

                                   ARTICLE VII
                              Amendments and Repeal

              Except as otherwise specifically provided in this Restated
         Certificate of Incorporation, the Corporation reserves the right at any
         time, and from time to time, to amend, alter, change or repeal any
         provision contained in this Restated Certificate of Incorporation, and
         other provisions authorized by the laws of the State of Delaware at the
         time in force may be added or inserted, in the manner now or hereafter
         prescribed by law; and all rights, preferences and privileges of
         whatsoever nature conferred upon stockholders, directors or any other
         persons whomsoever by and pursuant to this Restated Certificate of
         Incorporation in its present form or as hereafter amended are granted
         subject to the rights reserved in this Article VII.

                                  ARTICLE VIII
                          Compromises and Arrangements

              Whenever a compromise or arrangement is proposed between the
         Corporation and its creditors or any class of them and/or between the
         Corporation and its stockholders or any class of them, any court of
         equitable jurisdiction within the State of Delaware may, on the
         application in a summary way of the Corporation or of any creditor or
         stockholder thereof or on the application of any receiver or receivers
         appointed for the Corporation under Section 291 of the Delaware General
         Corporation Law or on the application of trustees in dissolution or of
         any receiver or receivers appointed for the Corporation under Section
         279 of the Delaware General Corporation Law, order a meeting of the
         creditors or class or creditors, and/or of the stockholders or class of
         stockholders of the Corporation, as the case may be, to be summoned in
         such manner as such court directs. If a majority in number representing
         three-fourths in value of the creditors or class of creditors, and/or
         of the stockholders or class of stockholders of the Corporation, as the
         case may be, agree to any compromise or arrangement and to any
         reorganization of the


                                       -4-


<PAGE>   5





         Corporation as a consequence of such compromise or arrangement, then
         such compromise or arrangement and such reorganization shall, if
         sanctioned by the court to which such application has been made, be
         binding on all the creditors or class of creditors, and/ or on all of
         the stockholders or class of stockholders of the Corporation, as the
         case may be, and also on the Corporation.

                                   ARTICLE IX
                             Limitation of Liability

              No director of the Corporation shall be liable to the Corporation
         or its stockholders for monetary damages for breach of his or her
         fiduciary duty as director; provided, however, that nothing contained
         in this Article shall eliminate or limit the liability of a director:

                   (a)  for any breach of the director's duty of loyalty to
         the Corporation or its stockholders;

                   (b)  for acts or omissions not in good faith or which
         involve intentional misconduct or a knowing violation of the law;

                   (c)  under Section 174 of the General Corporation Law of
         the State of Delaware; or

                   (d)  for any transaction from which the director derived
         improper personal benefit.

              No amendment to or repeal of this Article IX shall apply to or
         have any effect on the liability or alleged liability of any director
         of the Corporation for or with respect to any acts or omissions of such
         director occurring prior to such amendment or repeal.

                                    ARTICLE X
                                 Indemnification

              A. Actions, Suits and Proceedings Other than by or in the Right of
         the Corporation. The Corporation shall indemnify each person who was or
         is a party or is threatened to be made a party to any threatened,
         pending or completed action, suit or proceeding, whether civil,
         criminal, administrative or investigative (other than an action by or
         in the right of the Corporation), by reason of the fact that such
         person is or was, or has agreed to become, a director or officer of the
         Corporation, or is or was serving, or has agreed to serve, at the
         request of the Corporation, as a director, officer or trustee of, or in
         a similar capacity with, another corporation, partnership, joint
         venture, trust or other enterprise (including any employee benefit
         plan) (all such persons being referred to hereafter as an 
         "Indemnitee"),


                                       -5-


<PAGE>   6





         or by reason of any action alleged to have been taken or omitted in
         such capacity, against all expenses (including attorneys' fees),
         judgments, fines and amounts paid in settlement actually and reasonably
         incurred by such person or on such person's behalf in connection with
         such action, suit or proceeding and any appeal therefrom, if such
         person acted in good faith and in a manner such person reasonably
         believed to be in, or not opposed to, the best interests of the
         Corporation, and, with respect to any criminal action or proceeding,
         had no reasonable cause to believe such person's conduct was unlawful.
         The termination of any action, suit or proceeding by judgment, order,
         settlement, conviction or upon a plea of nolo contendere or its
         equivalent, shall not, of itself, create a presumption that the person
         did not act in good faith and in a manner which such person reasonably
         believed to be in, or not opposed to, the best interests of the
         Corporation, and, with respect to any criminal action or proceeding,
         had reasonable cause to believe that such person's conduct was
         unlawful. Notwithstanding anything to the contrary in this Article,
         except as set forth in paragraph (G) below, the Corporation shall not
         indemnify an Indemnitee seeking indemnification in connection with a
         proceeding (or part thereof) initiated by the Indemnitee unless the
         initiation thereof was approved by the Board of Directors of the
         Corporation.

              B. Actions or Suits by or in the Right of the Corporation. The
         Corporation shall indemnify any Indemnitee who was or is a party or is
         threatened to be made a party to any threatened, pending or completed
         action or suit by or in the right of the Corporation to procure a
         judgment in its favor by reason of the fact that such person is or was,
         or has agreed to become, a director or officer of the Corporation, or
         is or was serving, or has agreed to serve, at the request of the
         Corporation, as a director, officer or trustee of, or in a similar
         capacity with, another corporation, partnership, joint venture, trust
         or other enterprise (including any employee benefit plan), or by reason
         of any action alleged to have been taken or omitted in such capacity,
         against all expenses (including attorneys' fees) and amounts paid in
         settlement actually and reasonably incurred by such person or on such
         person's behalf in connection with such action, suit or proceeding and
         any appeal therefrom, if such person acted in good faith and in a
         manner such person reasonably believed to be in, or not opposed to, the
         best interests of the Corporation, except that no indemnification shall
         be made in respect of any claim, issue or matter as to which such
         person shall have been adjudged to be liable to the Corporation unless
         and only to the extent that the Court of Chancery of Delaware or the
         court in which such action or suit was brought shall determine upon
         application that, despite the adjudication of such liability but in
         view of all the circumstances of the case, such person is fairly and
         reasonably entitled to indemnity for such expenses (including
         attorneys' fees) which the Court of Chancery of Delaware or such other
         court shall deem proper.


                                       -6-


<PAGE>   7






              C. Indemnification for Expenses of Successful Party.
         Notwithstanding the other provisions of this Article, to the extent
         that an Indemnitee has been successful, on the merits or otherwise, in
         defense of any action, suit or proceeding referred to in paragraphs (A)
         and (B) of this Article, or in defense of any claim, issue or matter
         therein, or on appeal from any such action, suit or proceeding, the
         Indemnitee shall be indemnified against all expenses (including
         attorneys' fees) actually and reasonably incurred by such person or on
         such person's behalf in connection therewith. Without limiting the
         foregoing, if any action, suit or proceeding is disposed of, on the
         merits or otherwise (including a disposition without prejudice),
         without (i) the disposition being adverse to the Indemnitee, (ii) an
         adjudication that the Indemnitee was liable to the Corporation, (iii) a
         plea of guilty or nolo contendere by the Indemnitee, (iv) an
         adjudication that the Indemnitee did not act in good faith and in a
         manner reasonably believed to be in or not opposed to the best
         interests of the Corporation, and (v) with respect to any criminal
         proceeding, an adjudication that the Indemnitee had reasonable cause to
         believe such person's conduct was unlawful, the Indemnitee shall be
         considered for the purposes hereof to have been wholly successful with
         respect thereto.

              D. Notification and Defense of Claim. As a condition precedent to
         the right to be indemnified, the Indemnitee must notify the Corporation
         in writing as soon as practicable of any action, suit, proceeding or
         investigation involving the Indemnitee for which indemnity will or
         could be sought. With respect to any action, suit, proceeding or
         investigation of which the Corporation is so notified, the Corporation
         will be entitled to participate therein at its own expense and/or to
         assume the defense thereof at its own expense, with legal counsel
         reasonably acceptable to the Indemnitee. After notice from the
         Corporation to the Indemnitee of its election so to assume such
         defense, the Corporation shall not be liable to the Indemnitee for any
         legal or other expenses subsequently incurred by the Indemnitee in
         connection with such claim, other than as provided below in this
         paragraph (D). The Indemnitee shall have the right to employ the
         Indemnitee's own counsel in connection with such claim, but the fees
         and expenses of such counsel incurred after notice from the Corporation
         of its assumption of the defense thereof shall be at the expense of the
         Indemnitee unless (i) the employment of counsel by the Indemnitee has
         been authorized by the Corporation, (ii) counsel to the Indemnitee
         shall have reasonably concluded that there may be a conflict of
         interest or position on any significant issue between the Corporation
         and the Indemnitee in the conduct of the defense of such action or
         (iii) the Corporation shall not in fact have employed counsel to assume
         the defense of such action, in each of which cases the fees and
         expenses of counsel for the Indemnitee


                                       -7-


<PAGE>   8







         shall be at the expense of the Corporation, except as otherwise
         expressly provided by this Article. The Corporation shall not be
         entitled, without the consent of the Indemnitee, to assume the defense
         of any claim brought by or in the right of the Corporation or as to
         which counsel for the Indemnitee shall have reasonably made the
         conclusion provided for in clause (ii) above.

              E. Advance of Expenses. Subject to the provisions of paragraph (F)
         below, in the event that the Corporation does not assume the defense
         pursuant to paragraph (D) of this Article of any action, suit,
         proceeding or investigation of which the Corporation receives notice
         under this Article, any expenses (including attorneys' fees) incurred
         by an Indemnitee in defending a civil or criminal action, suit,
         proceeding or investigation or any appeal therefrom shall be paid by
         the Corporation in advance of the final disposition of such matter,
         provided, however, that the payment of such expenses incurred by an
         Indemnitee in advance of the final disposition of such matter shall be
         made only upon receipt of an undertaking by or on behalf of the
         Indemnitee to repay all amounts so advanced in the event that it shall
         ultimately be determined that the Indemnitee is not entitled to be
         indemnified by the Corporation as authorized in this Article. Such
         undertaking may be accepted without reference to the financial ability
         of such person to make such repayment.

              F. Procedure for Indemnification. In order to obtain
         indemnification or advancement of expenses pursuant to paragraphs (A),
         (B), (C) or (E) of this Article, the Indemnitee shall submit to the
         Corporation a written request, including in such request such
         documentation and information as is reasonably available to the
         Indemnitee and is reasonably necessary to determine whether and to what
         extent the Indemnitee is entitled to indemnification or advancement of
         expenses. Any such indemnification or advancement of expenses shall be
         made promptly, and in any event within 60 days after receipt by the
         Corporation of the written request of the Indemnitee, unless with
         respect to requests under paragraphs (A), (B) or (E) the Corporation
         determines within such 60-day period that the Indemnitee did not meet
         the applicable standard of conduct set forth in paragraphs (A) or (B),
         as the case may be. Such determination shall be made in each instance
         by (i) a majority vote of a quorum of the directors of the Corporation
         consisting of persons who are not at that time parties to the action,
         suit or proceeding in question ("disinterested directors"), (ii) if no
         such quorum is obtainable, a majority vote of a committee of two or
         more disinterested directors, (iii) a majority vote of a quorum of the
         outstanding shares of stock of all classes entitled to vote for
         directors, voting as a single class, which quorum shall consist of
         stockholders who are not at that time parties to the action, suit or
         proceeding in question, (iv) independent legal counsel (who may be
         regular legal counsel to the Corporation), or (v) a court of competent
         jurisdiction.


                                       -8-


<PAGE>   9







              G. Remedies. The right to indemnification or advances as granted
         by this Article shall be enforceable by the Indemnitee in any court of
         competent jurisdiction if the Corporation denies such request, in whole
         or in part, or if no disposition thereof is made within the 60-day
         period referred to above in paragraph (F). Unless otherwise required by
         law, the burden of proving that the Indemnitee is not entitled to
         indemnification or advancement of expenses under this Article shall be
         on the Corporation. Neither the failure of the Corporation to have made
         a determination prior to the commencement of such action that
         indemnification is proper in the circumstances because the Indemnitee
         has met the applicable standard of conduct, nor an actual determination
         by the Corporation pursuant to paragraph (F) that the Indemnitee has
         not met such applicable standard of conduct, shall be a defense to the
         action or create a presumption that the Indemnitee has not met the
         applicable standard of conduct. The Indemnitee's expenses (including
         attorneys' fees) incurred in connection with successfully establishing
         the Indemnitee's right to indemnification, in whole or in part, in any
         such proceeding shall also be indemnified by the Corporation.

              H. Subsequent Amendment. No amendment, termination or repeal of
         this Article or of the relevant provisions of the General Corporation
         Law of Delaware or any other applicable laws shall affect or diminish
         in any way the rights of any Indemnitee to indemnification under the
         provisions hereof with respect to any action, suit, proceeding or
         investigation arising out of or relating to any actions, transactions
         or facts occurring prior to the final adoption of such amendment,
         termination or repeal.

              I. Other Rights. The indemnification and advancement of expenses
         provided by this Article shall not be deemed exclusive of any other
         rights to which an Indemnitee seeking indemnification or advancement of
         expenses may be entitled under any law (common or statutory), agreement
         or vote of stockholders or disinterested directors or otherwise, both
         as to action in such Indemnitee's official capacity and as to action in
         any other capacity while holding office for the Corporation, and shall
         continue as to an Indemnitee who has ceased to be a director or
         officer, and shall inure to the benefit of the estate, heirs, executors
         and administrators of the Indemnitee. Nothing contained in this Article
         shall be deemed to prohibit, and the Corporation is specifically
         authorized to enter into, agreements with officers and directors
         providing indemnification rights and procedures different from those
         set forth in this Article. In addition, the Corporation may, to the
         extent authorized from time to time by its Board of Directors, grant
         indemnification rights to other employees or agents of the Corporation
         or other persons serving the Corporation and such rights may be
         equivalent to, or greater or less than, those set forth in this
         Article.


                                       -9-


<PAGE>   10






              J. Partial Indemnification. If an Indemnitee is entitled under any
         provision of this Article to indemnification by the Corporation for
         some or a portion of the expenses (including attorneys' fees),
         judgments, fines or amounts paid in settlement actually and reasonably
         incurred by such Indemnitee or on such Indemnitee's behalf in
         connection with any action, suit, proceeding or investigation and any
         appeal therefrom but not, however, for the total amount thereof, the
         Corporation shall nevertheless indemnify the Indemnitee for the portion
         of such expenses (including attorneys' fees), judgments, fines or
         amounts paid in settlement to which the Indemnitee is entitled.

              K.   Insurance.  The Corporation may purchase and maintain
         insurance, at its expense, to protect itself and any director,
         officer, employee or agent of the Corporation or another corpora-
         tion, partnership, joint venture, trust or other enterprise
         (including any employee benefit plan) against any expense,
         liability or loss incurred by the Indemnitee in any such capacity,
         or arising out of the Indemnitee's status as such, whether or not
         the Corporation would have the power to indemnify such person
         against such expense, liability or loss under the General
         Corporation Law of Delaware.

              L. Merger or Consolidation. If the Corporation is merged into or
         consolidated with another corporation and the Corporation is not the
         surviving corporation, the surviving corporation shall assume the
         obligations of the Corporation under this Article with respect to any
         action, suit, proceeding or investigation arising out of or relating to
         any actions, transactions or facts occurring prior to the date of such
         merger or consolidation.

              M. Savings Clause. If this Article or any portion hereof shall be
         invalidated on any ground by any court of competent jurisdiction, then
         the Corporation shall nevertheless indemnify each Indemnitee as to any
         expenses (including attorneys' fees), judgments, fines and amounts paid
         in settlement in connection with any action, suit, proceeding or
         investigation, whether civil, criminal or administrative, including an
         action by or in the right of the Corporation, to the fullest extent
         permitted by any applicable portion of this Article that shall not have
         been invalidated and to the fullest extent permitted by applicable law.

              N.   Definitions.  Terms used herein and defined in
         Section 145(h) and Section 145(i) of the General Corporation Law
         of Delaware shall have the respective meanings assigned to such
         terms in such Section 145(h) and Section 145(i).





                                      -10-


<PAGE>   11






              O. Subsequent Legislation. If the General Corporation Law of
         Delaware is amended after adoption of this Article to expand further
         the indemnification permitted to Indemnitees, then the Corporation
         shall indemnify such persons to the fullest extent permitted by the
         General Corporation Law of Delaware, as so amended.

                                   ARTICLE XI
                                Special Meetings

              A special meeting of the stockholders for any purpose may be
         called by the Board, the Chairman of the Board, if any, the President,
         the Secretary or the recordholders of at least 20% of the shares of
         stock of the Corporation issued and outstanding entitled to vote at
         such meeting, to be held at such place, date and hour as shall be
         designated in the notice or waiver of notice thereof.

                                   ARTICLE XII
                              Anti-Takeover Statute

              Section 203 of the General Corporation Law of Delaware, as it may
         be amended from time to time, shall apply to the Corporation.


              IN WITNESS WHEREOF, the undersigned has caused this Restated
         Certificate of Incorporation to be duly executed on its behalf as of
         May 13, 1996.

                                  BIOTRANSPLANT INCORPORATED



                                  By:  /s/ Elliot Lebowitz
                                       -------------------------------
                                       Elliot Lebowitz
                                       President and Chief Executive
                                       Officer














                                        -11-

<PAGE>   1


                                                               EXHIBIT 4.2

                                                           







                              BIO-TRANSPLANT, INC.


                           Incorporated under the laws
                            of the State of Delaware


                                     BY-LAWS




                          As adopted on March 23, 1990


<PAGE>   2




                              BIO-TRANSPLANT, INC.

                                     BY-LAWS

                                      INDEX

                                                                           PAGE
             I.    Offices

                   1.   Registered Office
                   2.   Other Offices

            II.    Meeting of Stockholders; Stockholders'
                   Consent in Lieu of Meeting

                    1.  Annual Meetings
                    2.  Special Meetings
                    3.  Notice of Meetings
                    4.  Quorum
                    5.  Organization
                    6.  Order of Business
                    7.  Voting
                    8.  Inspection
                    9.  List of Stockholders
                   10.  Stockholder's Consent in Lieu
                        of Meeting

           III.    Board of Directors

                    1.  General Powers
                    2.  Number and Term of Office
                    3.  Election of Directors
                    4.  Resignation, Removal and Vacancies
                    5.  Meetings

                        (a)  Annual Meetings
                        (b)  Other Meetings
                        (c)  Notice of Meetings
                        (d)  Place of Meetings
                        (e)  Quorum and Manner of Acting
                        (f)  Organization

                    6.  Directors' Consent in Lieu of Meeting
                    7.  Action by Means of Conference Telephone
                        or Similar Communications Equipment
                    8.  Committees





<PAGE>   3





            IV.    Officers

                    1.  Executive Officers
                    2.  Authority and Duties
                    3.  Other Officers
                    4.  Term of Office, Resignation and Removal
                    5.  Vacancies
                    6.  The Chairman of the Board
                    7.  The President
                    8.  The Treasurer
                    9.  The Secretary

             V.    Contracts, Checks, Drafts, Bank Accounts, Etc.

                    1.  Execution of Documents
                    2.  Deposits
                    3.  Proxies in Respect of Stock or Other
                        Securities of Other Corporations

            VI.    Shares and Their Transfer; Fixing Record Date

                    1.  Certificates for Shares
                    2.  Record
                    3.  Transfer and Registration of Stock
                    4.  Addresses of Stockholders
                    5.  Lost, Destroyed and Mutilated
                        Certificates
                    6.  Regulations
                    7.  Fixing Date for Determination of
                        Stockholders of Record

           VII.    Seal

          VIII.    Fiscal Year

            IX.    Indemnification and Insurance

                    1.  Indemnification
                    2.  Insurance

             X.    Amendments


<PAGE>   4




                              BIO-TRANSPLANT, INC.

                                    ARTICLE I

                                     OFFICES

              SECTION 1.  Registered Office.  The registered office of BIO-
         TRANSPLANT, INC. (the "Corporation") in the State of Delaware
         shall be at 1209 Orange Street, City of Wilmington, County of New
         Castle, and the registered agent in charge thereof shall be
         Corporation Trust Company.

              SECTION 2.  Other Offices.  The Corporation may also have an
         office or offices at other place or places within or without the
         State of Delaware.

                                   ARTICLE II

                       Meetings of Stockholders; Stockholders'
                           Consent in Lieu of Meeting

              SECTION 1. Annual Meetings. The annual meeting of the stockholders
         for the election of directors, and for the transaction of such other
         business as may properly come before the meeting, shall be held at such
         place, date and hour as shall be fixed by the Board of Directors (the
         "Board") and designated in the notice or waiver of notice thereof;
         except that no annual meeting need be held if all actions, including
         the election of directors, required by the General Corporation Law of
         the State of Delaware, as may be amended from time to time (the
         "Delaware Statute"), to be taken at a stockholders' annual meeting are
         taken by written consent in lieu of meeting pursuant to Section 10 of
         this Article II.

              SECTION 2. Special Meetings. A special meeting of the stockholders
         for any purpose may be called by the Board, the Chairman of the Board,
         if any, the President, the Secretary or the recordholders of at least a
         majority of the shares of stock of the Corporation issued and
         outstanding entitled to vote at such meeting, to be held at such place,
         date and hour as shall be designated in the notice or waiver of notice
         thereof.

              SECTION 3. Notice of Meetings. Except as otherwise required by
         statute or by the Certificate of Incorporation, as amended or restated
         from time to time (the "Certificate of Incorporation"), or these
         By-laws, notice of each annual or special meeting of the stockholders
         shall be given to each stockholder of record entitled to vote at such
         meeting not less than 10 or more than 60 days before the day on which
         the meeting is to be held, by delivering written notice thereof to him
         personally, or by mailing a copy of


                                       -1-


<PAGE>   5







         such notice, postage prepaid, directly to him at his address as it
         appears in the records of the Corporation, or by transmitting such
         notice to him at such address by telegraph, cable or other telephonic
         transmission. Every such notice shall state the place and the date and
         hour of the meeting, and, in case of a special meeting, the purposes
         for which the meeting is called. Notice of any meeting of stockholders
         shall not be required to be given to any stockholder who shall attend
         such meeting in person or by proxy, or who shall, in person or by
         attorney thereunto authorized, waive such notice in writing, either
         before or after such meeting. Except as otherwise required by the
         Delaware Statute or these By-laws, neither the business to be
         transacted at, nor the purpose of, any meeting of the stockholders need
         be specified in any such waiver of notice. Notice of any adjourned
         meeting of stockholders shall not be required to be given, except when
         expressly required by law.

              SECTION 4. Quorum. At each meeting of the stockholders, except
         where otherwise provided by the Certificate of Incorporation or these
         By-laws, the holders of a majority of the issued and outstanding shares
         of stock of the Corporation entitled to vote at such meeting, present
         in person or represented by proxy, shall constitute a quorum for the
         transaction of business. In the absence of a quorum a majority in
         interest of the stockholders present in person or represented by proxy
         and entitled to vote, or, in the absence of all the stockholders
         entitled to vote, any officer entitled to preside at, or act as
         secretary of, such meeting, shall have the power to adjourn the meeting
         from time to time, until stockholders holding the requisite amount of
         stock shall be present or represented. At any such adjourned meeting at
         which a quorum shall be present, any business may be transacted which
         might have been transacted at the meeting as originally called.

              SECTION 5.  Organization.  At each meeting of the
         stockholders, one of the following shall act as chairman of the
         meeting and preside thereat, in the following order of precedence:

                   (a)  the Chairman of the Board, if any;

                   (b)  the President;

                   (c)  any other officer of the Corporation designated by the
                        Board to act as chairman of such meeting and to preside
                        thereat if the Chairman of the Board, if any, or the
                        President shall be absent from such meeting; or





                                         -2-


<PAGE>   6







                   (d)  a stockholder of record who shall be chosen chairman of
                        such meeting by a majority in voting interest of the
                        stockholders present in person or by proxy and entitled
                        to vote thereat.

         The Secretary, or if he shall be presiding over such meeting in
         accordance with the provisions of this Section 5 or absent from such
         meeting, the person (who shall be an Assistant Secretary, if an
         Assistant Secretary has been appointed and is present) whom the
         chairman of such meeting shall appoint, shall act as secretary of such
         meeting and keep the minutes thereof.

              SECTION 6. Order of Business. The order of business at each
         meeting of the stockholders shall be determined by the chairman of such
         meeting, but such order of business may be changed by a majority in
         voting interest of those present in person or by proxy at such meeting
         and entitled to vote thereat.

              SECTION 7. Voting. Except as otherwise provided by law or by the
         Certificate of Incorporation or these By-laws, at each meeting of the
         stockholders, every stockholder of the Corporation shall be entitled to
         one vote in person or by proxy for each share of stock of the
         Corporation held by him and registered in his name on the books of the
         Corporation on the date fixed pursuant to Section 7 of Article VI as
         the record date for the determination of stockholders entitled to vote
         at such meeting. Persons holding stock in a fiduciary capacity shall be
         entitled to vote the shares so held. Persons whose stock is pledged
         shall be entitled to vote, unless in the transfer by the pledgor on the
         books of the Corporation, he has expressly empowered the pledgee to
         vote thereon, in which case only the pledgee or his proxy may represent
         such stock and vote thereon. If shares or other securities having
         voting power stand in the record of two or more persons, whether
         fiduciaries, members of a partnership, joint tenants, tenants in
         common, tenants by the entirety or otherwise, or if two or more persons
         have the same fiduciary relationship respecting the same shares, unless
         the Secretary shall be given written notice to the contrary and shall
         be furnished with a copy of the instrument or order appointing them or
         creating the relationship wherein it is so provided, their acts with
         respect to voting shall have the following effect:

                   (a)  if only one votes, his act binds all;

                   (b)  if more than one votes, the act of the majority so
                        voting binds all; and

                   (c)  if more than one votes, but the vote is evenly split on
                        any particular matter, such shares shall be voted in the
                        manner provided by law.


                                       -3-


<PAGE>   7




         If the instrument so filed shows that any such tenancy is held in
         unequal interests, a majority or even-split for the purposes of this
         Section 7 shall be a majority or even-split in interest. The
         Corporation shall not vote directly or indirectly any share of its own
         capital stock. Any vote of stock may be given by the stockholder
         entitled thereto in person or by his proxy appointed by an instrument
         in writing, subscribed by such stockholder or by his attorney thereunto
         authorized, delivered to the secretary of the meeting; provided,
         however, that no proxy shall be voted after three years from its date,
         unless said proxy provides for a longer period. At all meetings of the
         stockholders at which a quorum shall be present, all matters (except
         where other provision is made by law, the Certificate of Incorporation
         or these By-laws) shall be decided by the vote of a majority in
         interest of the stockholders present in person or by proxy at such
         meeting and entitled to vote thereon. Unless demanded by a stockholder
         present in person or by proxy at any meeting and entitled to vote
         thereon, the vote on any question need not be by ballot. Upon a demand
         by any such stockholder for a vote by ballot upon any question, such
         vote by ballot shall be taken. On a vote by ballot, each ballot shall
         be signed by the stockholder voting, or by his proxy, if there be such
         proxy, and shall state the number of shares voted.

              SECTION 8. Inspection. The chairman of the meeting may at any time
         appoint two or more inspectors to serve at any meeting of the
         stockholders. Any inspector may be removed, and a new inspector or
         inspectors appointed, by the Board at any time. Such inspectors shall
         decide upon the qualifications of voters, accept and count the votes
         for and against the question, respectively, declare the results of such
         vote, and subscribe and deliver to the secretary of the meeting a
         certificate stating the number of shares of stock issued and
         outstanding and entitled to vote thereon and the number of shares voted
         for and against the question, respectively. The inspectors need not be
         stockholders of the Corporation, and any director or officer of the
         Corporation may be an inspector on any question other than a vote for
         or against his election to any position with the Corporation or on any
         other question in which he may be directly interested. Before acting as
         herein provided, each inspector shall subscribe an oath faithfully to
         execute the duties of an inspector with strict impartiality and
         according to the best of his ability.

              SECTION 9. List of Stockholders. It shall be the duty of the
         Secretary or other officer of the Corporation who shall have charge of
         its stock ledger to prepare and make, at least 10 days before every
         meeting of the stockholders, a complete list of the stockholders
         entitled to vote thereat, arranged in alphabetical order, and showing
         the address of each stockholder and the number of shares registered in
         the name of each stockholder. Such list


                                       -4-


<PAGE>   8







         shall be open to the examination of any stockholder, for any purpose
         germane to any such meeting, during ordinary business hours, for a
         period of at least 10 days prior to such meeting, either at a place
         within the city where such meeting is to be held, which place shall be
         specified in the notice of the meeting or, if not so specified, at the
         place where the meeting is to be held. Such list shall also be produced
         and kept at the time and place of the meeting during the whole time
         thereof, and may be inspected by any stockholder who is present.

              SECTION 10. Stockholders' Consent In Lieu of Meeting. Any action
         required by the Delaware Statute to be taken at any annual or special
         meeting of such stockholders, may be taken without a meeting, without
         prior notice and without a vote, by a consent in writing, as permitted
         by the Delaware Statute.

                                   ARTICLE III

                               Board of Directors

              SECTION 1. General Powers. The business, property and affairs of
         the Corporation shall be managed by or under the direction of the
         Board, which may exercise all such powers of the Corporation and do all
         such lawful acts and things as are not by law or by the Certificate of
         Incorporation directed or required to be exercised or done by the
         stockholders.

              SECTION 2. Number and Term of Office. Except as may be otherwise
         expressly provided by the Certificate of Incorporation, the number of
         directors shall be three or such other number as shall be fixed from
         time to time by the Board. Directors need not be stockholders. Each
         director shall hold office until his successor is elected and
         qualified, or until his earlier death or resignation or removal in the
         manner hereinafter provided.

              SECTION 3. Election of Directors. At each meeting of the
         stockholders for the election of directors at which a quorum is
         present, the persons receiving the greatest number of votes, up to the
         number of directors to be elected, of the stockholders present in
         person or by proxy and entitled to vote thereon shall be the directors;
         provided, that no stockholder shall be allowed to cumulate his votes.
         Unless an election by ballot shall be demanded as provided in Section 7
         of Article II, election of directors may be conducted in any manner
         approved at such meeting.

              SECTION 4. Resignation, Removal and Vacancies. Any director may
         resign at any time by giving written notice to the Board, the Chairman
         of the Board, if any, the President or the Secretary. Such resignation
         shall take effect at the time specified therein or, if the time be not
         specified, upon receipt thereof; and,


                                       -5-


<PAGE>   9





         unless otherwise specified therein, the acceptance of such resignation
         shall not be necessary to make it effective.

              Any director or the entire Board may be removed, with or without
         cause, at any time by vote of the holders of a majority of the shares
         then entitled to vote at an election of directors, or by written
         consent of the stockholders pursuant to Section 10 of Article II.

              Vacancies occurring in the Board for any reason may be filled by
         vote of the stockholders or by their written consent pursuant to
         Section 10 of Article II or by vote of the Board or by the directors'
         written consent pursuant to Section 6 of this Article III. Such
         vacancies may be filled by vote of a majority of the directors then in
         office, whether or not less than a quorum.

              SECTION 5.  Meetings.

                   (a) Annual Meetings. As soon as practicable after each annual
         election of directors, the Board shall meet for the purpose of
         organization and the transaction of other business, unless it shall
         have transacted all such business by written consent pursuant to
         Section 6 of this Article III.

                   (b) Other Meetings. Other meetings of the Board shall be held
         at such times and places as the Board, the Chairman of the Board, if
         any, the President or any two directors shall from time to time
         determine.

                   (c) Notice of Meetings. The Secretary shall give notice to
         each director of each meeting, including the time, place and purpose of
         such meeting. Notice of each such meeting shall be mailed to each
         director, addressed to him at his residence or usual place of business,
         at least three business days before the day on which such meeting is to
         be held, or shall be sent to him at such place by telegraph, cable,
         wireless or other form of recorded communication, or delivered
         personally or by telephone not later than 24 hours before the time at
         which such meeting is to be held, but notice need not be given to any
         director who shall attend such meeting. A written waiver of notice,
         signed by the person entitled thereto, whether before or after the time
         of the meeting stated therein, shall be deemed equivalent to notice.

                   (d) Place of Meetings. The Board may hold its meetings at
         such place or places within or without the State of Delaware as the
         Board may from time to time determine, or as shall be designated in the
         respective notices or waivers of notice thereof.

                   (e)  Quorum and Manner of Acting.  A majority of the
         total number of directors shall be present in person at any


                                       -6-


<PAGE>   10





         meeting of the Board in order to constitute a quorum for the
         transaction of business at such meeting, and the vote of a majority of
         those directors present at any such meeting at which a quorum is
         present shall be necessary for the passage of any resolution or act of
         the Board, except as otherwise expressly required by law, the
         Certificate of Incorporation or these By-laws. In the absence of a
         quorum for any such meeting, a majority of the directors present
         thereat may adjourn such meeting from time to time until a quorum shall
         be present.

                   (f)  Organization.  At each meeting of the Board, one of
         the following shall act as chairman of the meeting and preside, in
         the following order of precedence:

                        (i)  the Chairman of the Board, if any;

                       (ii)  the President (if a director); or

                      (iii)  any director chosen by a majority of the
                             directors present.

         The Secretary or, in the case of his absence, any person (who shall be
         an Assistant Secretary, if an Assistant Secretary has been appointed
         and is present) whom the chairman of the meeting shall appoint shall
         act as secretary of such meeting and keep the minutes thereof.

              SECTION 6. Directors' Consent In Lieu of Meeting. Any action
         required or permitted to be taken at any meeting of the Board may be
         taken without a meeting, without prior notice and without a vote, if a
         consent in writing, setting forth the action so taken, shall be signed
         by all the directors and such consent is filed with the minutes of the
         proceedings of the Board.

              SECTION 7. Action by Means of Conference Telephone or Similar
         Communications Equipment. Any one or more members of the Board may
         participate in a meeting of the Board by means of conference telephone
         or similar communications equipment by means of which all persons
         participating in the meeting can hear each other, and participation in
         a meeting by such means shall constitute presence in person at such
         meeting.

              SECTION 8. Committees. The Board may designate one or more
         committees, each consisting of at least one director of the
         Corporation, which to the extent provided in such resolution, except as
         otherwise provided by the Delaware Statute, shall have and may exercise
         the powers of the Board in the management of the business and affairs
         of the Corporation and may authorize the seal of the Corporation to be
         affixed to all papers which may require it, such committee or
         committees to have such name or names as may


                                       -7-


<PAGE>   11





         be determined from time to time by resolution adopted by the Board. A
         majority of all the members of any such committee may determine its
         action and fix the time and place of its meetings, unless the Board
         shall otherwise provide. The Board shall have the power to change the
         members of any such committee at any time, either with or without
         cause, to fill vacancies and to discharge any such committee, either
         with or without cause, at any time.

                                   ARTICLE IV

                                    Officers

              SECTION 1. Executive Officers. The executive officers of the
         Corporation shall be a President, a Treasurer and a Secretary and may
         include a Chairman of the Board and such other officers as the Board
         may appoint pursuant to Section 3 of this Article IV specifically
         designated as executive officers of the Corporation. Any two or more
         offices may be held by the same person.

              SECTION 2. Authority and Duties. All offices, as between
         themselves and the Corporation, shall have such authority and perform
         such duties in the management of the Corporation as may be provided in
         these By-laws or, to the extent so provided, by the Board.

              SECTION 3. Other Officers. The Corporation may have such other
         officers, employees and agents as the Board may deem necessary,
         including one or more Vice Presidents, one or more Assistant
         Secretaries and one or more Assistant Treasurers, each of whom shall
         hold office for such period, have such authority, and perform such
         duties as the Board, the Chairman of the Board, if any, or the
         President may from time to time determine. The Board may delegate to
         any executive officer the power to appoint or remove any such officers,
         employees and agents.

              SECTION 4. Term of Office, Resignation and Removal. Subject to the
         provisions of Section 3 of this Article IV, all officers shall be
         elected or appointed by the Board and shall hold office for such term
         as may be prescribed by the Board. Each officer shall hold office until
         his successor has been elected or appointed and qualified or until his
         earlier death or resignation or removal in the manner hereinafter
         provided. The Board may require any officer to give security for the
         faithful performance of his duties.

              Any officer may resign at any time by giving written notice to the
         Board, the Chairman of the Board, if any, the President or the
         Secretary. Such resignation shall take effect at the time specified
         therein or, if the time be not specified, at the time it is accepted by
         action of the Board. Except as aforesaid, the


                                       -8-


<PAGE>   12





         acceptance of such resignation shall not be necessary to make it
         effective.

              Each officer, employee and agent shall be subject to removal at
         any time by the Board or by the stockholders of the Corporation, or by
         any executive officer to whom the Board has delegated the power to
         remove such officer, employee or agent, with or without cause.

              SECTION 5. Vacancies. If the office of President, Treasurer or
         Secretary becomes vacant for any reason, the Board shall fill such
         vacancy, and if any other office becomes vacant, the Board or any
         executive officer to whom the Board has delegated such power may fill
         such vacancy. Any officer appointed or elected to fill any vacancy
         shall serve only until such time as the unexpired term of his
         predecessor shall have expired unless otherwise provided upon such
         appointment or election or unless reappointed or reelected.

              SECTION 6. The Chairman of the Board. If there shall be a Chairman
         of the Board, he shall preside at meetings of the Board and of the
         stockholders at which he is present, and shall give counsel and advice
         to the Board and the officers of the Corporation on all subjects
         concerning the welfare of the Corporation and the conduct of its
         business. He shall perform such other duties as the Board may from time
         to time determine.

              SECTION 7. The President. The President shall be the chief
         executive officer of the Corporation, and unless a Chairman of the
         Board shall be appointed and present, the president shall preside at
         all meetings of the Board (if he is a director) and of the stockholders
         at which he is present. The President shall have general and active
         management and control of the business and affairs of the Corporation
         subject to the control of the Board, and shall see that all orders and
         resolutions of the Board are carried into effect.

              SECTION 8. The Treasurer. The Treasurer shall have the care and
         custody of the corporate funds and other valuable effects, including
         securities, and shall keep full and accurate accounts of receipts and
         disbursements in books belonging to the Corporation, and shall deposit
         all moneys and other valuable effects in the name and to the credit of
         the Corporation in such depositories as may be designated by the Board.
         The Treasurer shall disburse the funds of the Corporation as may be
         ordered by the Board, taking proper vouchers for such disbursements,
         and shall render to the Chairman of the Board, if any, the President
         and the directors, at regular meetings of the Board, or whenever they
         may require it, an account of all his transactions as Treasurer and of
         the financial condition of the Corporation, and shall perform all other
         duties


                                       -9-


<PAGE>   13







         incident to the office of Treasurer and such other duties as from time
         to time may be assigned to him by the Chairman of the Board, if any,
         the President or the Board.

              SECTION 9. The Secretary. The Secretary shall, to the extent
         practicable, attend all meetings of the Board and all meetings of the
         stockholders and shall record all votes and the minutes of all
         proceedings in a book to be kept for that purpose. He shall give, or
         cause to be given, notice of all meetings of the stockholders and of
         the Board. He shall keep in safe custody the seal of the Corporation
         and affix the same to any duly authorized instrument requiring it and,
         when so affixed, it shall be attested by his signature or by the
         signature of the Treasurer, an Assistant Treasurer or an Assistant
         Secretary. He shall keep in safe custody the certificate books and
         stockholder records and such other books and records as the Board may
         direct and shall perform all other duties incident to the office of
         Secretary and such other duties as from time to time may be assigned to
         him by the Chairman of the Board, if any, the President or the Board.

                                    ARTICLE V

                   Contracts, Checks, Drafts, Bank Accounts, Etc.

              SECTION 1. Execution of Documents. The Board shall designate the
         officers, employees and agents of the Corporation who shall have power
         to execute and deliver deeds, contracts, mortgages, bonds, debentures,
         checks, drafts and other orders for the payment of money and other
         documents for and in the name of the Corporation (including the power
         to affix the seal of the Corporation and to attest thereto), and may
         authorize such officers, employees and agents to delegate such power
         (including authority to redelegate) by written instrument to other
         officers, employees or agents of the Corporation; and, unless so
         designated or expressly authorized by these By-laws, no officer,
         employee or agent shall have any power or authority to bind the
         Corporation by any contract or engagement, to pledge its credit or to
         render it liable pecuniarily for any purpose or to any amount.

              SECTION 2. Deposits. All funds of the Corporation not otherwise
         employed shall be deposited from time to time to the credit of the
         Corporation or otherwise as the Board, the Treasurer or any other
         officer of the Corporation to whom power in this respect shall have
         been given by the Board, shall select.

              SECTION 3. Proxies in Respect of Stock or Other Securities of
         Other Corporations. The Board shall designate the officers of the
         Corporation who shall have authority from time to time to appoint an
         agent or agents of the Corporation to exercise in the name and on
         behalf of the Corporation the powers and rights which


                                      -10-


<PAGE>   14




         the Corporation may have as the holder of stock or other securities in
         any other corporation, and to vote or consent in respect of such stock
         or securities. Such designated officers may instruct the person or
         persons so appointed as to the manner of exercising such powers and
         rights, and such designated officers may execute or cause to be
         executed in the name and on behalf of the Corporation and under its
         corporate seal or otherwise, such written proxies, powers of attorney
         or other instruments as they may deem necessary or proper in order that
         the Corporation may exercise its powers and rights.

                                   ARTICLE VI

                    Shares and Their Transfer; Fixing Record Date

              SECTION 1. Certificates for Shares. Every owner of stock of the
         Corporation shall be entitled to have a certificate certifying the
         number and class or series of shares owned by him in the Corporation,
         which shall be in such form as shall be prescribed by the Board.
         Certificates shall be numbered and issued in consecutive order and
         shall be signed by, or in the name of, the Corporation by the Chairman
         of the Board, if any, the President or any Vice President and by the
         Treasurer (or an Assistant Treasurer) or the Secretary (or an Assistant
         Secretary). In case any officer or officers who shall have signed any
         such certificate or certificates shall cease to be such officer or
         officers of the Corporation, whether because of death, resignation or
         otherwise, before such certificate or certificates shall have been
         delivered by the Corporation, such certificate or certificates may
         nevertheless be adopted by the Corporation and be issued and delivered
         as though the person or persons who signed such certificate had not
         ceased to be such officer or officers of the Corporation.

              SECTION 2. Record. A record in one or more counterparts shall be
         kept of the name of the person, firm or corporation owning the shares
         represented by each certificate for stock of the Corporation issued,
         the number of shares represented by each such certificate, the date
         thereof and, in the case of cancellation, the date of cancellation.
         Except as otherwise expressly required by law, the person in whose name
         shares of stock stand on the stock record of the Corporation shall be
         deemed the owner thereof for all purposes as regards the Corporation.

              SECTION 3.  Transfer and Registration of Stock.

                   (a) The transfer of stock and certificates of stock which
         represent the stock of the Corporation shall be governed by Article 8
         of Subtitle 1 of Title 6 of the Delaware Code (the Uniform Commercial
         Code), as amended from time to time.


                                      -11-


<PAGE>   15





                   (b) Registration of transfers of shares of the Corporation
         shall be made only on the books of the Corporation upon request of the
         registered holder thereof, or of his attorney thereunto authorized by
         power of attorney duly executed and filed with the Secretary of the
         Corporation, and upon the surrender of the certificate or certificates
         for such shares properly endorsed or accompanied by a stock power duly
         executed.

              SECTION 4. Addresses of Stockholders. Each stockholder shall
         designate to the Secretary an address at which notices of meetings and
         all other corporate notices may be served or mailed to him, and, if any
         stockholder shall fail to designate such address, corporate notices may
         be served upon him by mail directed to him at his post office address,
         if any, as the same appears on the share record books of the
         Corporation or at his last known post office address.

              SECTION 5. Lost, Destroyed and Mutilated Certificates. The holder
         of any shares of the Corporation shall immediately notify the
         Corporation of any loss, destruction or mutilation of the certificate
         therefor, and the Board may, in its discretion, cause to be issued to
         him a new certificate or certificates for shares, upon the surrender of
         the mutilated certificates or, in the case of loss or destruction of
         the certificate, upon satisfactory proof of such loss or destruction,
         and the Board may, in its discretion, require the owner of the lost or
         destroyed certificate or his legal representative to give the
         Corporation a bond in such sum and with such surety or sureties as it
         may direct to indemnify the Corporation against any claim that may be
         made against it on account of the alleged loss or destruction of any
         such certificate.

              SECTION 6. Regulations. The Board may make such rules and
         regulations as it may deem expedient, not inconsistent with these
         By-laws, concerning the issue, transfer and registration of
         certificates for stock of the Corporation.

              SECTION 7.  Fixing Date for Determination of Stockholders of
         Record.

                   (a) In order that the Corporation may determine the
         stockholders entitled to notice of or to vote at any meeting of
         stockholders or any adjournment thereof, the Board may fix a record
         date, which record date shall not precede the date upon which the
         resolution fixing the record date is adopted by the Board, and which
         record date shall be not more than 60 nor less than 10 days before the
         date of such meeting. If no record date is fixed by the Board, the
         record date for determining stockholders entitled to notice of or to
         vote at a meeting of stockholders shall be at the close of business on
         the day next


                                      -12-


<PAGE>   16




         preceding the day on which notice is given, or, if notice is waived, at
         the close of business on the day next preceding the day on which the
         meeting is held. A determination of stockholders of record entitled to
         notice of or to vote at a meeting of stockholders shall apply to any
         adjournment of the meeting; provided, however, the Board may fix a new
         record date for the adjourned meeting.

                   (b) In order that the Corporation may determine the
         stockholders entitled to consent to corporate action in writing without
         a meeting, the Board may fix a record date, which record date shall not
         precede the date upon which the resolution fixing the record date is
         adopted by the Board, and which date shall be not more than 10 days
         after the date upon which the resolution fixing the record date is
         adopted by the Board. If no record date has been fixed by the Board,
         the record date for determining stockholders entitled to consent to
         corporate action in writing without a meeting, when no prior action by
         the Board is required by the Delaware Statute, shall be the first date
         on which a signed written consent setting forth the action taken or
         proposed to be taken is delivered to the Corporation by delivery to its
         registered office in this State, its principal place of business, or an
         officer or agent of the Corporation having custody of the book in which
         proceedings of meetings of stockholders are recorded. Delivery made to
         the Corporation's registered office shall be by hand or by certified or
         registered mail, return receipt requested. If no record date has been
         fixed by the Board and prior action by the Board is required by the
         Delaware Statute, the record date for determining stockholders entitled
         to consent to corporate action in writing without a meeting shall be at
         the close of business on the day on which the Board adopts the
         resolution taking such prior action.

                   (c) In order that the Corporation may determine the
         stockholders entitled to receive payment of any dividend or other
         distribution or allotment of any rights or the stockholders entitled to
         exercise any rights in respect of any change, conversion or exchange of
         stock, or for the purpose of any other lawful action, the Board may fix
         a record date, which record date shall not precede the date upon which
         the resolution fixing the record date is adopted, and which record date
         shall be not more than 60 days prior to such action. If no record date
         is fixed, the record date for determining stockholders for any such
         purpose shall be at the close of business on the day on which the Board
         adopts the resolution relating thereto.







                                      -13-


<PAGE>   17





                                   ARTICLE VII

                                      Seal

              The Board may provide a corporate seal, which shall be in the form
         of a circle and shall bear the full name of the Corporation and the
         words and figures "Corporate Seal, -- 1990 Delaware."

                                   ARTICLE VII

                                   Fiscal Year

              The fiscal year of the Corporation shall be the calendar year
         unless otherwise determined by the Board.

                                   ARTICLE IX

                          Indemnification and Insurance

              SECTION 1.  Indemnification.

                   (a) As provided in the Certificate of Incorporation, to the
         fullest extent permitted by the Delaware Statute, a director of this
         Corporation shall not be liable to the Corporation or its stockholders
         for breach of fiduciary duty as a director.

                   (b) Without limitation of any provision eliminating or
         limiting the liability of a director pursuant to the Delaware Statute,
         any person who was or is made a party or is threatened to be made a
         party to or is otherwise involved in any threatened, pending or
         completed action, suit or proceeding, whether civil, criminal,
         administrative or investigative (hereinafter a "proceeding"), by reason
         of the fact that he or she is or was a director, officer, employee or
         agent of the Corporation or is or was serving at the request of the
         Corporation as a director, officer, employee or agent of another
         corporation or of a partnership, joint venture, trust or other
         enterprise, including service with respect to an employee benefit plan
         (hereinafter an "indemnitee"), whether the basis of such proceeding is
         alleged action in an official or in any other capacity while holding
         such office, shall be indemnified and held harmless by the Corporation
         to the fullest extent authorized by the Delaware Statute, as the same
         exists or may hereafter be amended (but, in the case of any such
         amendment, only to the extent that such amendment permits the
         Corporation to provide broader indemnification rights than permitted
         prior thereto), against all expense, liability and loss (including
         attorneys' fees, judgments, fines, ERISA excise taxes or penalties and
         amounts paid in settlement) actually and reasonably incurred or
         suffered by such indemnitee in connection therewith, and such
         indemnification shall continue as to an


                                      -14-


<PAGE>   18







         indemnitee who has ceased to be a director or designated officer and
         shall inure to the benefit of the indemnitee's heirs, executors and
         administrators; provided, however, that, except as provided in Section
         1(c) of this Article IX with respect to proceedings to enforce rights
         to indemnification, the Corporation shall indemnify any such indemnitee
         in connection with a proceeding initiated by such indemnitee only if
         such proceeding initiated by such indemnitee was authorized by the
         Board. The right to indemnification cornered in this Article IX shall
         be a contract right and shall include the right to be paid by the
         Corporation the expenses incurred in defending any such proceeding in
         advance of its final disposition (hereinafter an "advancement of
         expenses"); only upon delivery to the Corporation of an undertaking
         (hereinafter an "undertaking"), by or on behalf of such indemnitee, to
         repay all amounts so advanced if it shall ultimately be determined by
         final judicial decision from which there is no further right to appeal
         (hereinafter a "final adjudication") that such indemnitee is not
         entitled to be indemnified for such expenses under this Section or
         otherwise.

                   (c) If a claim under Section 1(b) of this Article IX is not
         paid in full by the Corporation within 60 days after a written claim
         has been received by the Corporation, except in the case of a claim for
         an advancement of expenses, in which case the applicable period shall
         be 20 days, the indemnitee may at any time thereafter bring suit
         against the Corporation to recover the unpaid amount of the claim. If
         successful in whole or in part in any such suit, or in a suit brought
         by the Corporation to recover an advancement of expenses pursuant to
         the terms of any undertaking, the indemnitee shall be entitled to be
         paid also the expenses of prosecuting or defending such suit. In (i)
         any suit brought by the indemnitee to enforce a right to
         indemnification hereunder (but not in a suit brought by the indemnitee
         to enforce a right to an advancement of expenses) it shall be a defense
         that, and (ii) any suit by the Corporation to recover an advancement of
         expenses pursuant to the terms of an undertaking the Corporation shall
         be entitled to recover such expenses upon a final adjudication that,
         the indemnitee has not met the applicable standard of conduct set forth
         in the Delaware Statute. Neither the failure of the Corporation
         (including the Board, independent legal counsel or stockholders) to
         have made a determination prior to the commencement of such suit that
         indemnification of the indemnitee is proper in the circumstances
         because the indemnitee has met the applicable standard of conduct set
         forth in the Delaware Statute, nor an actual determination by the
         Corporation (including the Board, independent legal counsel or
         stockholders) that the indemnitee has not met such applicable standard
         of conduct, shall create a presumption that the indemnitee has not met
         the applicable standard of conduct or, in the case of such a suit
         brought by the indemnitee, be a defense to such suit. In any


                                      -15-


<PAGE>   19




         suit brought by the indemnitee to enforce a right to indemnification or
         to an advancement of expenses hereunder, or by the Corporation to
         recover an advancement of expenses pursuant to the terms of an
         undertaking, the burden of proving that the indemnitee is not entitled
         to be indemnified, or to such advancement of expenses, under this
         Section or otherwise shall be on the Corporation.

                   (d) The rights to indemnification and the advancement of
         expenses conferred in this Article IX shall not be exclusive of any
         other rights which any person may have or hereafter acquire pursuant to
         any statute, the Certificate of Incorporation, agreement, vote of
         stockholders or disinterested directors or otherwise.

              SECTION 2. Insurance. The Corporation may purchase and maintain
         insurance, at its expense, on behalf of any person who is or was a
         director, officer, employee or agent of the Corporation, or is or was
         serving at the request of the Corporation as a director, officer,
         employee or agent of another Corporation, partnership, joint venture,
         trust or other enterprise, against any expense, liability or loss,
         whether or not the Corporation would have the power to indemnify such
         person against such expense, liability or loss under this Article IX or
         the Delaware Statute.

                                    ARTICLE X

                                   Amendments

              Any by-law (including these By-laws) may be adopted, amended or
         repealed by the vote of the holders of a majority of the shares then
         entitled to vote at an election of directors or by consent of such
         stockholders pursuant to Section 10 of Article II, or by vote of the
         Board or by the directors' written consent pursuant to Section 6 of
         Article III.


















                                      -16-



<PAGE>   20





                               AMENDMENT TO BYLAWS


              The Bylaws of BioTransplant, Inc. be and hereby are amended
         as follows:

              1. Article II, Section 2 of the Bylaws is hereby deleted in its
         entirety and a new Section 2 inserted in lieu thereof which shall read
         as follows:

                   "SECTION 2. Special Meetings. A special meeting of the
                   stockholders for any purpose may be called by the Board, the
                   Chairman of the Board, if any, the President, the Secretrary
                   or the recordholders of at least 20% of the shares of stock
                   of the Corporation issued and outstanding entitled to vote at
                   such meeting, to be held at such place, date and hour as
                   shall be designated in the notice or waiver of notice
                   thereof."

              2. New Sections 11 and 12 will be added to Article II which shall
         read in their entirety as follows:

                   "SECTION 11. Nomination of Directors. Only persons who are
                   nominated in accordance with the following procedures shall
                   be eligible for election as directors. Nomination for
                   election to the Board of Directors of the corporation at a
                   meeting of stockholders may be made by the Board of Directors
                   or by any stockholder of the corporation entitled to vote for
                   the election of directors at such meeting who complies with
                   the notice procedures set forth in this Section 11. Such
                   nominations, other than those made by or on behalf of the
                   Board of Directors or by a stockholder owning more than 5% of
                   the outstanding capital stock of the Corporation, shall be
                   made by notice in writing delivered or mailed by first class
                   United States mail, postage prepaid, to the Secretary, and
                   received not less than 60 days nor more than 90 days prior to
                   such meeting; provided, however, that if less than 70 days'
                   notice or prior public disclosure of the date of the meeting
                   is given to stockholders, such nomination shall have been
                   mailed or delivered to the Secretary not later than the close
                   of business on the 10th day following the date on which the
                   notice of the meeting was mailed or such public disclosure
                   was made, whichever occurs first. Such notice shall set forth
                   (a) as to each proposed nominee (i) the name, age, business




<PAGE>   21




                   address and, if known, residence address of each such
                   nominee, (ii) the principal occupation or employment of each
                   such nominee, (iii) the number of shares of stock of the
                   corporation which are beneficially owned by each such
                   nominee, and (iv) any other information concerning the
                   nominee that must be disclosed as to nominees in proxy
                   solicitations pursuant to Regulation 14A under the Securities
                   Exchange Act of 1934, as amended (including such person's
                   written consent to be named as a nominee and to serve as a
                   director if elected); and (b) as to the stockholder giving
                   the notice (i) the name and address, as they appear on the
                   corporation's books, of such stockholder and (ii) the class
                   and number of shares of the corporation which are
                   beneficially owned by such stockholder. The corporation may
                   require any proposed nominee to furnish such other
                   information as may reasonably be required by the corporation
                   to determine the eligibility of such proposed nominee to
                   serve as a director of the corporation.

                   The chairman of the meeting may, if the facts warrant,
                   determine and declare to the meeting that a nomination was
                   not made in accordance with the foregoing procedure, and if
                   he should so determine, he shall so declare to the meeting
                   and the defective nomination shall be disregarded."

                   "SECTION 12. Notice of Business at Annual Meetings. At an
                   annual meeting of the stockholders, only such business shall
                   be conducted as shall have been properly brought before the
                   meeting. To be properly brought before an annual meeting,
                   business must be (a) specified in the notice of meeting (or
                   any supplement thereto) given by or at the direction of the
                   Board of Directors, (b) otherwise properly brought before the
                   meeting by or at the direction of the Board of Directors, or
                   (c) otherwise properly brought before an annual meeting by a
                   stockholder. For business to be properly brought before an
                   annual meeting by a stockholder, owning less than 5% of the
                   outstanding capital stock of the Corporation, the stockholder
                   must have given timely notice thereof in writing to the
                   Secretary. To be timely, a stockholder's notice must be
                   delivered to or mailed and received at the principal
                   executive offices of the corporation not less than 60 days
                   nor more than 90 days prior to the meeting; provided,
                   however, that in the event that less than 70 days' notice or





<PAGE>   22



                   prior public disclosure of the date of the meeting is given
                   or made to stockholders, notice by the stockholder to be
                   timely must be so received not later than the close of
                   business on the 10th day following the date on which such
                   notice of the date of the meeting was mailed or such public
                   disclosure was made, whichever occurs first. A stockholder's
                   notice to the Secretary shall set forth as to each matter the
                   stockholder proposes to bring before the annual meeting (a) a
                   brief description of the business desired to be brought
                   before the annual meeting and the reasons for conducting such
                   business at the annual meeting, (b) the name and address, as
                   they appear on the corporation's books, of the stockholder
                   proposing such business, (c) the class and number of shares
                   of the corporation which are beneficially owned by the
                   stockholder, and (d) any material interest of the stockholder
                   in such business. Notwithstanding anything in these By-Laws
                   to the contrary, no business shall be conducted at any annual
                   meeting except in accordance with the procedures set forth in
                   this Section 1.11 and except that any stockholder proposal
                   which complies with Rule 14a-8 of the proxy rules (or any
                   successor provision) promulgated under the Securities
                   Exchange Act of 1934, as amended, and is to be included in
                   the corporation's proxy statement for an annual meeting of
                   stockholders shall be deemed to comply with the requirements
                   of this Section 1.11.

                   The chairman of the meeting shall, if the facts warrant,
                   determine and declare to the meeting that business was not
                   properly brought before the meeting in accordance with the
                   provisions of this Section 1.11, and if he should so
                   determine, the chairman shall so declare to the meeting that
                   any such business not properly brought before the meeting
                   shall not be transacted."


         ADOPTED BY THE BOARD OF DIRECTORS ON MARCH 1, 1996.





<PAGE>   1
                                                                EXHIBIT 11.1
 
                          BIOTRANSPLANT INCORPORATED
<TABLE>
                            COMPUTATION OF PRO FORMA NET LOSS PER COMMON SHARE (1)
 
<CAPTION>
                                                                               THREE MONTHS ENDED MARCH 31,
                                                                                  1995             1996
                                                                              -------------     -----------
    <S>                                                                        <C>              <C>
    Net Loss................................................................   $(2,719,434)     $ (987,947)
                                                                               ===========      ==========
    Shares Used in Computing Pro Forma Net Loss Per Common Share:
         Weighted Average Common Stock Outstanding During the Period........       120,035         126,594
         Conversion of Redeemable Convertible Preferred Stock(2)............     3,212,896       4,328,704
         Dilutive Effect of Common Equivalent Shares Issued Subsequent to
           March 1, 1995(3).................................................       676,048         676,048
                                                                               -----------      ----------
                                                                                 4,008,979       5,131,346
                                                                               ===========      ==========
    Pro Forma Net Loss Per Common Share.....................................   $      (.68)     $     (.19)
                                                                               ===========      ==========
<FN> 
- ---------------
(1) Historical net loss per common share has not been separately presented, as the amounts would not be 
    meaningful.
 
(2) Effective with the closing of the Company's initial public offering of common stock, all shares of
    redeemable convertible preferred stock automatically converted into shares of common stock.
    Accordingly the equivalent number of weighted average common shares that would have been outstanding
    during each period presented have been included as outstanding.

(3) Pursuant to Securities and Exchange Commission Staff Accounting Bulletin No. 83, common stock,
    preferred stock, stock options and warrants issued at prices below the initial public offering price
    per share ("cheap stock") during the twelve month period immediately preceding the filing date of the       
    Company's Registration Statement for its initial public offering have been included as outstanding for
    all periods presented. The dilutive effect of the common and common stock equivalents was computed in
    accordance with the treasury stock method.

</TABLE>

<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
CONSOLIDATED BALANCE SHEET @ MARCH 31, 1996 AND THE CONSOLIDATED STATEMENT
OF OPERATIONS FOR THE THREE MONTHS ENDED MARCH 31, 1996 AND IS QUALIFIED IN
ITS ENTIRETY BY REFERENCE TO SUCH CONSOLIDATED FINANCIAL STATEMENTS
</LEGEND>
<MULTIPLIER> 1
<CURRENCY> U.S. DOLLARS
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          DEC-31-1996
<PERIOD-START>                             JAN-01-1996
<PERIOD-END>                               MAR-31-1996
<EXCHANGE-RATE>                                      1
<CASH>                                       6,167,920
<SECURITIES>                                         0
<RECEIVABLES>                                   24,168
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                             6,565,609
<PP&E>                                       3,670,891
<DEPRECIATION>                               1,986,592
<TOTAL-ASSETS>                               8,407,384
<CURRENT-LIABILITIES>                        1,542,264
<BONDS>                                              0
<COMMON>                                         1,266
                       36,186,820
                                          0
<OTHER-SE>                                (29,829,415)
<TOTAL-LIABILITY-AND-EQUITY>                 8,407,384
<SALES>                                              0
<TOTAL-REVENUES>                             2,075,697
<CGS>                                                0
<TOTAL-COSTS>                                3,012,436
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                              51,208
<INCOME-PRETAX>                              (987,947)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                          (987,947)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                 (987,947)
<EPS-PRIMARY>                                    (.19)
<EPS-DILUTED>                                    (.19)
        

</TABLE>


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