MAGAININ PHARMACEUTICALS INC
SC 13D/A, 1996-04-24
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549

SCHEDULE 13D
Under the Securities Exchange Act of 1934

Amendment No.:  2*

Name of Issuer:  Magainin Pharmaceuticals, Inc.

Title of Class of Securities:  Common Stock

CUSIP Number: 559 036 108

          (Name, Address and Telephone Number of Person
       Authorized To Receive Notices and Communications)  

         Norman S. Schleifer, c/o Oracle Partners, L.P.,
   712 Fifth Avenue, 45th Floor, NY, NY 10019; (212) 373-9200

     (Date of Event which Requires Filing of this Statement)

                         April 24, 1996

If the filing person has previously filed a statement on Schedule
13G to report the acquisition which is the subject of this
Schedule 13D, and is filing this schedule because of
Rule 13d-1(b)(3) or (4), check the following box [   ].

Check the following line if a fee is being paid with this
statement   .  (A fee is not required only if the filing person:
(1) has a previous statement on file reporting beneficial
ownership of more than five percent of the class of securities
described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of
class.  See Rule 13d-7).

*The remainder of this cover page shall be filled out for a
reporting person's initial filing on this form with respect to
the subject class of securities, and for any subsequent amendment
containing information which would alter the disclosures provided
in a prior cover page.

The information required in the remainder of this cover page
shall not be deemed to be "filed" for the purpose of Section 18
of the Securities Exchange Act of 1934 ("Act") or otherwise
subject to the liabilities of that section of the Act but shall
be subject to all other provisions of the Act (however, see the
Notes).



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CUSIP No. 559 036 108

1.  Name of Reporting Person
    S.S. or I.R.S. Identification No. of Above Person

         Larry N. Feinberg

2.  Check the Appropriate Box if a Member of a Group

         a.   
         b.   

3.  SEC Use Only

4.  Source of Funds

         WC

5.  Check box if Disclosure of Legal Proceedings is Required
    Pursuant to Items 2(d) or 2(e)

6.  Citizenship or Place of Organization

         U.S.A.

Number of Shares Beneficially Owned by Each Reporting Person
With:

7.  Sole Voting Power:

         1,134,900

8.  Shared Voting Power:


9.  Sole Dispositive Power:

         1,134,900

10. Shared Dispositive Power:

         39,000

11. Aggregate Amount Beneficially Owned by Each Reporting Person

         1,173,900

12. Check Box if the Aggregate Amount in Row (11) Excludes
    Certain Shares





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13. Percent of Class Represented by Amount in Row (11)

         6.88%

14. Type of Reporting Person

         IN




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This Amendment No. 2 to a Statement on Schedule 13D is being
filed by Larry N. Feinberg in order to amend the Statement on
Schedule 13D filed by Mr. Feinberg with respect to the
outstanding shares of common stock of Magainin Pharmaceuticals,
Inc. dated April 18, 1995, as amended by Amendment No. 1.

Item 1.  Security and Issuer

         No change.

Item 2.  Identity and Background

         No change, except that the business address of Mr.
         Feinberg is 712 Fifth Avenue, 45th Floor, New York, New
         York 10019.

Item 3.  Source and Amount of Funds or Other Consideration

         As of the date hereof, Mr. Feinberg may be deemed to
         beneficially own 1,173,900 shares of Common Stock.
         These shares are held by the Partnership and managed
         accounts over which Mr. Feinberg has investment
         discretion.   The funds used for the purchase of the
         Common Stock held in the managed accounts over which Mr.
         Feinberg has investment discretion came from each
         managed account's own funds.  The funds used for the
         purchase of the Common Stock held by the Partnership
         came from capital contributions to the Partnership by
         its general and limited partners and other working
         capital funds of the Partnership.  No borrowed funds
         were used to purchase any of the 1,173,900 shares of
         Common Stock, other than any borrowed funds used for
         working capital purposes in the ordinary course of
         business.

Item 4.  Purpose of Transaction

         The 1,173,900 shares of Common Stock were acquired for
         investment purposes.  Mr. Feinberg and the other general
         partner of the Partnership have concerns about the lack
         of strategic direction of Magainin as compared to other
         similarly situated biopharmaceutical companies.  The
         Chairman of the Board of Magainin and certain other
         directors of Magainin have been advised of these
         concerns.  These concerns also have been discussed with
         a limited number of other holders of the Common Stock.
         A meeting among the general partners of the Partnership,
         certain other shareholders of Magainin, the Chairman of
         the Board of Magainin and another director of Magainin
         is scheduled to be held on April 24, 1996 for the
         purpose of discussing these concerns.



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         Mr. Feinberg and the other general partner of the
         Partnership have no current plans or proposals which
         relate to or would result in any of the events described
         in Items (a) through (j) of the instructions to Item 4
         of Schedule 13D.  However, the general partners of the
         Partnership reserve the right to discuss company
         business with management, make proposals to management
         and/or take other actions to influence the management of
         Magainin should it deem such actions appropriate.

Item 5.  Interest in Securities of the Issuer

         Based on Magainin's definitive proxy statement dated
         April 8, 1996, there are believed to be 17,069,184
         shares of Common Stock outstanding.  Therefore, Mr.
         Feinberg may be deemed to beneficially own an aggregate
         of approximately 6.88% of the outstanding shares of
         Common Stock.  Mr. Feinberg has the sole power to vote,
         direct the vote, dispose of or direct the disposition of
         1,134,900 shares of the Common Stock, and has shared
         power to dispose of or direct the disposition of 39,000
         shares of the Common Stock.

Item 6.  Contracts, Arrangements, Understandings or
         Relationships With Respect to Securities of
         the Issuer

         No change.

Item 7.  Material to be Filed as Exhibits

         Attached hereto as Exhibit A is a description of the
         transactions in the Common Stock that were effected by
         Mr. Feinberg during the past 60 days.



<PAGE>

         Signature

        The undersigned, after reasonable inquiry and to the best
of his knowledge and belief, certifies that the information set
forth in this statement is true, complete and correct.

April 24, 1995


                             /s/  Larry N. Feinberg
                                                   
                                  Larry N. Feinberg



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                                                   EXHIBIT A


                   Purchase Transactions



                        Number of Shares
         Trade Date     of Common Stock    Price Per Share


         3/29/96        30,000             $10.47

         3/01/96        28,000             $13.00







































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